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Conserved domains on  [gi|15238110|ref|NP_196587|]
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Phototropic-responsive NPH3 family protein [Arabidopsis thaliana]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 13605777)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and NPH3 domain-containing protein may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 214-463 9.09e-100

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


:

Pssm-ID: 460777  Cd Length: 218  Bit Score: 302.49  E-value: 9.09e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110   214 YNDIATLDIDHFMRVITTMKARRAKPQITGKIIMKYADNFLPVINDdlegikgyglgknelQFSVNRGRMEESNSlgcqE 293
Cdd:pfam03000   4 FEDLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLPGLSR---------------SSSSSASRSEDDNS----K 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110   294 HKETIESLVSVLPPQSGAVSCHFLLRMLKTSIVYSASPALISDLEKRVGMALEDANVCDLLIPNFKNEEqqervRIFEFF 373
Cdd:pfam03000  65 QRELLETIVSLLPSEKGSVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEE-----TLYDVD 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110   374 LMheqqqvlgkpsISKLLDNYLAEIAKDPYLPITKFQVLAEMLPENAWKCHDGLYRAIDMFLKTHPSLSDHDRRRLCKTM 453
Cdd:pfam03000 140 LK-----------VAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLCRLM 208

                         250
                  ....*....|
gi 15238110   454 NCEKLSLDAC 463
Cdd:pfam03000 209 DCQKLSLEAC 218
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 43-148 6.10e-38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18312:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 105  Bit Score: 135.54  E-value: 6.10e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110  43 SWYVKSQIPTDLSIQVNDITFKAHKFPLISKCGYISSIElKPSTSENGYHLKLENFPGGADTFETILKFCYNLPLDLNPL 122
Cdd:cd18312   1 SWFRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLA-SSSSESDPSEIELNDFPGGAEAFELVAKFCYGMPINLTAT 79

                        90       100
                ....*....|....*....|....*.
gi 15238110 123 NVAPLRCASEYLYMTEEFEAGNLISK 148
Cdd:cd18312  80 NVVGLRCAAEYLEMTESGNLGNLIDK 105
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 214-463 9.09e-100

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 302.49  E-value: 9.09e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110   214 YNDIATLDIDHFMRVITTMKARRAKPQITGKIIMKYADNFLPVINDdlegikgyglgknelQFSVNRGRMEESNSlgcqE 293
Cdd:pfam03000   4 FEDLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLPGLSR---------------SSSSSASRSEDDNS----K 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110   294 HKETIESLVSVLPPQSGAVSCHFLLRMLKTSIVYSASPALISDLEKRVGMALEDANVCDLLIPNFKNEEqqervRIFEFF 373
Cdd:pfam03000  65 QRELLETIVSLLPSEKGSVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEE-----TLYDVD 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110   374 LMheqqqvlgkpsISKLLDNYLAEIAKDPYLPITKFQVLAEMLPENAWKCHDGLYRAIDMFLKTHPSLSDHDRRRLCKTM 453
Cdd:pfam03000 140 LK-----------VAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLCRLM 208

                         250
                  ....*....|
gi 15238110   454 NCEKLSLDAC 463
Cdd:pfam03000 209 DCQKLSLEAC 218
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 43-148 6.10e-38

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 135.54  E-value: 6.10e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110  43 SWYVKSQIPTDLSIQVNDITFKAHKFPLISKCGYISSIElKPSTSENGYHLKLENFPGGADTFETILKFCYNLPLDLNPL 122
Cdd:cd18312   1 SWFRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLA-SSSSESDPSEIELNDFPGGAEAFELVAKFCYGMPINLTAT 79

                        90       100
                ....*....|....*....|....*.
gi 15238110 123 NVAPLRCASEYLYMTEEFEAGNLISK 148
Cdd:cd18312  80 NVVGLRCAAEYLEMTESGNLGNLIDK 105
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 47-153 1.78e-03

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 38.39  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110    47 KSQIPTDLSIQVNDITFKAHKFPLISKCGYISSIELKPSTSENGYHLKLENFPggADTFETILKFCYNLPLdLNPLNVAP 126
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVS--PEDFEALLEFMYTGKL-ISEENVDD 82

                          90       100
                  ....*....|....*....|....*..
gi 15238110   127 LrcaseyLYMTEEFEAGNLISKTEAFI 153
Cdd:pfam00651  83 L------LAAADKLQIPSLVDKCEEFL 103
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 53-153 8.51e-03

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 36.13  E-value: 8.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110     53 DLSIQVNDITFKAHKFPLISKCGYISSIELKPSTSENGYHLKLENFPggADTFETILKFCYNLPLDLNPlnvaplRCASE 132
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVS--PEDFRALLNFLYTGKLDLPE------ENVEE 72

                           90       100
                   ....*....|....*....|.
gi 15238110    133 YLYMTEEFEAGNLISKTEAFI 153
Cdd:smart00225  73 LLELADYLQIPGLVELCEEFL 93
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 214-463 9.09e-100

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 302.49  E-value: 9.09e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110   214 YNDIATLDIDHFMRVITTMKARRAKPQITGKIIMKYADNFLPVINDdlegikgyglgknelQFSVNRGRMEESNSlgcqE 293
Cdd:pfam03000   4 FEDLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLPGLSR---------------SSSSSASRSEDDNS----K 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110   294 HKETIESLVSVLPPQSGAVSCHFLLRMLKTSIVYSASPALISDLEKRVGMALEDANVCDLLIPNFKNEEqqervRIFEFF 373
Cdd:pfam03000  65 QRELLETIVSLLPSEKGSVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEE-----TLYDVD 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110   374 LMheqqqvlgkpsISKLLDNYLAEIAKDPYLPITKFQVLAEMLPENAWKCHDGLYRAIDMFLKTHPSLSDHDRRRLCKTM 453
Cdd:pfam03000 140 LK-----------VAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLCRLM 208

                         250
                  ....*....|
gi 15238110   454 NCEKLSLDAC 463
Cdd:pfam03000 209 DCQKLSLEAC 218
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 43-148 6.10e-38

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 135.54  E-value: 6.10e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110  43 SWYVKSQIPTDLSIQVNDITFKAHKFPLISKCGYISSIElKPSTSENGYHLKLENFPGGADTFETILKFCYNLPLDLNPL 122
Cdd:cd18312   1 SWFRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLA-SSSSESDPSEIELNDFPGGAEAFELVAKFCYGMPINLTAT 79

                        90       100
                ....*....|....*....|....*.
gi 15238110 123 NVAPLRCASEYLYMTEEFEAGNLISK 148
Cdd:cd18312  80 NVVGLRCAAEYLEMTESGNLGNLIDK 105
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-134 1.43e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 54.87  E-value: 1.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110  52 TDLSIQVNDITFKAHKFPLISKCGYISSIELKPSTSENGYHLKLENFPggADTFETILKFCYNLPLDLNPLNVAPLRCAS 131
Cdd:cd18186   2 CDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVS--PEAFEALLDYIYTGELELSEENVEELLAAA 79


                ...
gi 15238110 132 EYL 134
Cdd:cd18186  80 DKL 82
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 52-142 6.44e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 45.03  E-value: 6.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110  52 TDLSIQVNDITFKAHKFPLISKCGYISSIeLKPSTSE-NGYHLKLENFPggADTFETILKFCYNLPLDLNPLNVAPLRCA 130
Cdd:cd18314   7 SDVVLCVGDRKFFAHRIVLCARSPVFRSM-LTGSMIEsNLKEVTLEDVE--PEIFETVLKYMYTGQVTLSEENVLDLLML 83

                        90
                ....*....|..
gi 15238110 131 SEYlYMTEEFEA 142
Cdd:cd18314  84 ASK-YQVPDLEK 94
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-138 3.78e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 43.38  E-value: 3.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110  53 DLSIQVNDITFKAHKFPLISKCGYISSIeLKPSTSENGYHLKLENFPGGADTFETILKFCYNLPLDLNPLNVAPLRCASE 132
Cdd:cd18330  20 DCSIIVEGRIFKAHRNILFANSGYFRAL-LIHYIQDSGRHSTASLDIVTSEAFSIILDFLYSGKLDLCSENVIEVMSAAS 98


                ....*.
gi 15238110 133 YLYMTE 138
Cdd:cd18330  99 YLQMTD 104
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-138 3.81e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 43.18  E-value: 3.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110  53 DLSIQVNDITFKAHKFPLISKCGYISSIeLKPSTSENGYHL--KLENFpgGADTFETILKFCYNLPLDLNPLNVAPLRCA 130
Cdd:cd18199  20 DCSIIVEGRIFKAHRNVLFASSGYFRML-LSHYIQDTGRPStaSFDVF--SSDAFSIILDFVYSGKLSLTSQNVIEVMSA 96


                ....*...
gi 15238110 131 SEYLYMTE 138
Cdd:cd18199  97 ASYLQMTD 104
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-153 9.37e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 42.12  E-value: 9.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110  53 DLSIQVNDITFKAHKFPLISKCGYISSIeLKPSTSENGYHLKLENFPGGADTFETILKFCYNLPLDLNPLNVAPLRCASE 132
Cdd:cd18329  23 DCSILVEGQVFKAHRNVLFASSGYFKML-LSQNAKETGQPTVATFDVFSPDTFTIILDFVYSGKLSLTSQNVIEVMSAAS 101

                        90       100
                ....*....|....*....|.
gi 15238110 133 YLYMTEefeagnLISKTEAFI 153
Cdd:cd18329 102 YLQMTD------VISVCKTFI 116
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 52-127 1.41e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 41.86  E-value: 1.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110  52 TDLSIQVNDITFKAHKFPLISKCGYISSIELKPSTSENGYHLKLENFPGGAdtFETILKFCY----NLPLDLNPLNVAPL 127
Cdd:cd18286  18 SDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAA--VSFVLLFIYggvlDLPDDVNLGELLSL 95
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 56-134 1.93e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 40.34  E-value: 1.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110  56 IQVNDITFKAHKFPLISKCGY----ISSIELKPSTSEngYHLKLENFPGgadtFETILKFCYNLPLDLNPLNVAPLRCAS 131
Cdd:cd01165   3 LVVEGEKFHVNKELLAQSSEYfralFRGGFRESGQAE--INLRDISPED----FRALLEFLYGGKRDLDASNLLELLEAA 76


                ...
gi 15238110 132 EYL 134
Cdd:cd01165  77 NFL 79
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-136 4.84e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 40.22  E-value: 4.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110  47 KSQIPTDLSIQVNDITFKAHKFPLISKCGYISSIELKPStSENGYHLKLenfPGGAD--TFETILKFCYNLPLDLNPLNV 124
Cdd:cd18332  15 KRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRV-GEGVSVLTL---PSGLEarGFQLLLDFMYTSRLPLTPRTV 90

                        90
                ....*....|..
gi 15238110 125 APLRCASEYLYM 136
Cdd:cd18332  91 PAVLAAATYLQM 102
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-138 1.09e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 38.97  E-value: 1.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110  53 DLSIQVNDITFKAHKFPLISKCGYISSIELKpsTSENGYHLKLENFpgGADTFETILKFCYNLPLDLNPLNVAPLRCASE 132
Cdd:cd18217  20 DCTIVIGQFQFKAHRNVLAAFSEYFGAQYKD--TEDNIVFLDQSQV--SADGFQKLLEFIYTGNLNLDSWNVAEIHQAAS 95


                ....*.
gi 15238110 133 YLYMTE 138
Cdd:cd18217  96 YLGMEE 101
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 47-153 1.78e-03

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 38.39  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110    47 KSQIPTDLSIQVNDITFKAHKFPLISKCGYISSIELKPSTSENGYHLKLENFPggADTFETILKFCYNLPLdLNPLNVAP 126
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVS--PEDFEALLEFMYTGKL-ISEENVDD 82

                          90       100
                  ....*....|....*....|....*..
gi 15238110   127 LrcaseyLYMTEEFEAGNLISKTEAFI 153
Cdd:pfam00651  83 L------LAAADKLQIPSLVDKCEEFL 103
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-136 2.68e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 37.93  E-value: 2.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110  47 KSQIPTDLSIQVNDITFKAHKFPLISKCGYISSIelkpSTSENGYHLKLENFPGG--ADTFETILKFCYNLPLDLNPLNV 124
Cdd:cd18215  15 SRDILTDVVLVVGREQFRAHKTVLMACSGLFYSI----FTDQLKNNVSVINLDPEiePEGFRILLDFMYTSRLNLREGNI 90

                        90
                ....*....|..
gi 15238110 125 APLRCASEYLYM 136
Cdd:cd18215  91 MAVMATAMYLQM 102
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-142 4.27e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 37.73  E-value: 4.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110  50 IPTDLSIQVNDITFKAHKFPLISKCGYISSIEL---KPSTSENGYHLKLENfpggADTFETILKFCYNLPLDLNPLNVAP 126
Cdd:cd18230  20 ILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCqvqKTSDQATVTHLDIVT----AQGFKAIIDFMYSAHLALTSKNVIE 95

                        90
                ....*....|....*.
gi 15238110 127 LRCASEYLYMTEEFEA 142
Cdd:cd18230  96 VMSAASYLQMTDIVQA 111
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 53-113 4.33e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 36.88  E-value: 4.33e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15238110  53 DLSIQVNDITFKAHKFPLISKCGYISSI---ELKPSTSENGYHLK-LENFPGgaDTFETILKFCY 113
Cdd:cd18301  20 DVVFQVGGKTFPAHKFILASRSDYFRKLflsSLLTSEDAVGCDVVhIEKVPP--EIFEQLLQFIY 82
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 53-153 8.51e-03

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 36.13  E-value: 8.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238110     53 DLSIQVNDITFKAHKFPLISKCGYISSIELKPSTSENGYHLKLENFPggADTFETILKFCYNLPLDLNPlnvaplRCASE 132
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVS--PEDFRALLNFLYTGKLDLPE------ENVEE 72

                           90       100
                   ....*....|....*....|.
gi 15238110    133 YLYMTEEFEAGNLISKTEAFI 153
Cdd:smart00225  73 LLELADYLQIPGLVELCEEFL 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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