|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
38-474 |
5.83e-158 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 455.49 E-value: 5.83e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 38 ETKKIWYIVGPSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFTLGFNYGLLLGMASALETLCGQAFGAREYYMLG 117
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 118 VYMQRYWIILFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISAGV 197
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 198 SLAVHILVCWFFVYGYKLGIIGTMASVNVPWWLNIFILFLYSTR-GGCTLTWTGFSSEAFTGLLELTKLSASSGIMLCLE 276
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFsKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 277 NWYYKILMLMTGNLVnAKIAVDSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLMIGLFFT 356
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 357 VIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCYYLIGLPFGLTMGWIF 436
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399
|
410 420 430
....*....|....*....|....*....|....*...
gi 145357859 437 KFGVKGIWAGMIFgGTAIQTLILIIITTRCDWDNEAHK 474
Cdd:cd13132 400 GLGLKGLWIGLIA-GLILQAVILLLIILRTDWDKEAEK 436
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
48-388 |
4.35e-43 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 155.48 E-value: 4.35e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 48 PSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFTLgFNYGLLLGMASALETLCGQAFGAREYYMLGVYMQR-YWII 126
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFM-FLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQsLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 127 LFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISAGVSLAVHILVC 206
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 207 WFFVYGY--KLGIIGTMASVNVPWWLNIFILFLYSTRGG-CTLTWTGFSSEAFTGLLELTKLSASSGIMLCLENWYYKIL 283
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKkIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 284 MLMTGNLvnAKIAVDSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLMIGLFFTVIIVIFH 363
Cdd:TIGR00797 240 ALLVARL--GSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
330 340
....*....|....*....|....*
gi 145357859 364 DQIGSIFSSSEAVLNAVDNLSVLLA 388
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
39-450 |
1.25e-42 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 156.46 E-value: 1.25e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 39 TKKIWYIVGPSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFtLGFNYGLLLGMASALETLCGQAFGAREYYMLGV 118
Cdd:COG0534 7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPI-FFLLIALGIGLGVGGTALVAQALGAGDREEARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 119 YMQR-YWIILFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISAGV 197
Cdd:COG0534 86 VLGQaLLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 198 SLAVHILVCWFFVYGYKLGIIGTMASVNVPWWLNIFILFLYSTRGGCTLTWTGFS-SEAFTGLLELTKLSASSGIMLCLE 276
Cdd:COG0534 166 GNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDlRPDRKILKRILRIGLPAGLQQLAE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 277 NwyykILMLMTGNLVNA--KIAVDSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLMIGLF 354
Cdd:COG0534 246 S----LGFLVLNALVARlgTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 355 FTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCYYLIGLPFGLTMGw 434
Cdd:COG0534 322 LALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLA- 400
|
410
....*....|....*.
gi 145357859 435 IFKFGVKGIWAGMIFG 450
Cdd:COG0534 401 FLGLGLTGVWLALPIG 416
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
48-453 |
1.51e-22 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 99.89 E-value: 1.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 48 PSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFTLG---FNYGLLLgmasALETLCGQAFGAREYYMLG-VYMQRY 123
Cdd:PRK01766 20 PILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIWLPvilFGHGLLL----ALTPIVAQLNGAGRRERIAhQVRQGL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 124 WIILFLCCILLLPMYLFATPILKFIGQSDDIAELTG---TIALWVIPvhfAFAFFFPLNRFLQCQLKNKVIAISAGVSLA 200
Cdd:PRK01766 96 WLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVgylHALLWGIP---AYLLYQVLRSFIDGLGKTKPTMVIGFLGLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 201 VHILVCWFFVYGY----KLGIIGT-MASVNVpWWLNIFILFLYSTRGG---CTLTWTGFSSEAFTGLLELTKLSASSGIM 272
Cdd:PRK01766 173 INIPLNYIFIYGKfgfpELGGVGCgVATAIV-YWVMFLAMLIYIKRARrfrDFRLFKGLYKPDWAVIKRLLKLGLPIGLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 273 LCLENWYYKILMLMTGNLVNAKIAvdSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLMIG 352
Cdd:PRK01766 252 IFFEVSLFAVVTLLVSPLGTVTVA--AHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLAVGLGMA 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 353 LFFTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCYYLIGLPFGLTM 432
Cdd:PRK01766 330 LLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGLPLGYIL 409
|
410 420
....*....|....*....|.
gi 145357859 433 GWIFKFGVKGIWAGMIFGGTA 453
Cdd:PRK01766 410 ALTDPMGPFGFWIGLIIGLTA 430
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
269-429 |
4.72e-22 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 92.63 E-value: 4.72e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 269 SGIMLCLENWYYKILMLMTGNLvnAKIAVDSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLS 348
Cdd:pfam01554 2 IALENLLQSLYSLIDTLFVGHL--GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 349 LMIGLFFTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCyYLIGLPF 428
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPL 158
|
.
gi 145357859 429 G 429
Cdd:pfam01554 159 N 159
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
38-474 |
5.83e-158 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 455.49 E-value: 5.83e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 38 ETKKIWYIVGPSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFTLGFNYGLLLGMASALETLCGQAFGAREYYMLG 117
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 118 VYMQRYWIILFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISAGV 197
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 198 SLAVHILVCWFFVYGYKLGIIGTMASVNVPWWLNIFILFLYSTR-GGCTLTWTGFSSEAFTGLLELTKLSASSGIMLCLE 276
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFsKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 277 NWYYKILMLMTGNLVnAKIAVDSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLMIGLFFT 356
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 357 VIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCYYLIGLPFGLTMGWIF 436
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399
|
410 420 430
....*....|....*....|....*....|....*...
gi 145357859 437 KFGVKGIWAGMIFgGTAIQTLILIIITTRCDWDNEAHK 474
Cdd:cd13132 400 GLGLKGLWIGLIA-GLILQAVILLLIILRTDWDKEAEK 436
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
48-388 |
4.35e-43 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 155.48 E-value: 4.35e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 48 PSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFTLgFNYGLLLGMASALETLCGQAFGAREYYMLGVYMQR-YWII 126
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFM-FLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQsLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 127 LFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISAGVSLAVHILVC 206
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 207 WFFVYGY--KLGIIGTMASVNVPWWLNIFILFLYSTRGG-CTLTWTGFSSEAFTGLLELTKLSASSGIMLCLENWYYKIL 283
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKkIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 284 MLMTGNLvnAKIAVDSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLMIGLFFTVIIVIFH 363
Cdd:TIGR00797 240 ALLVARL--GSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
330 340
....*....|....*....|....*
gi 145357859 364 DQIGSIFSSSEAVLNAVDNLSVLLA 388
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
39-450 |
1.25e-42 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 156.46 E-value: 1.25e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 39 TKKIWYIVGPSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFtLGFNYGLLLGMASALETLCGQAFGAREYYMLGV 118
Cdd:COG0534 7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPI-FFLLIALGIGLGVGGTALVAQALGAGDREEARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 119 YMQR-YWIILFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISAGV 197
Cdd:COG0534 86 VLGQaLLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 198 SLAVHILVCWFFVYGYKLGIIGTMASVNVPWWLNIFILFLYSTRGGCTLTWTGFS-SEAFTGLLELTKLSASSGIMLCLE 276
Cdd:COG0534 166 GNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDlRPDRKILKRILRIGLPAGLQQLAE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 277 NwyykILMLMTGNLVNA--KIAVDSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLMIGLF 354
Cdd:COG0534 246 S----LGFLVLNALVARlgTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 355 FTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCYYLIGLPFGLTMGw 434
Cdd:COG0534 322 LALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLA- 400
|
410
....*....|....*.
gi 145357859 435 IFKFGVKGIWAGMIFG 450
Cdd:COG0534 401 FLGLGLTGVWLALPIG 416
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
38-450 |
6.77e-36 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 138.02 E-value: 6.77e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 38 ETKKIWYIVGPSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFTLGFnYGLLLGMASALETLCGQAFGAREYYMLG 117
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 118 VYMQRYWIILFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISAGV 197
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 198 SLAVHILVCWFFVYGY----KLGIIGT-MASVNVpWWLNIFILFLYSTRG---GCTLTWTGFSSEAFTGLLELTKLSASS 269
Cdd:cd13131 160 ALVLNIPLNYVLIFGKfglpALGGAGAgLATAIV-YWLMFLALAFYIRRHkrfRRYRLFARFWRPDWARLKELLRLGLPI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 270 GIMLCLENWYYKILMLMTGNLVNAKIAvdSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSL 349
Cdd:cd13131 239 GLTIFFEVSLFAAVALLMGRLGTTVLA--AHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 350 MIGLFFTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCYYLIGLPFG 429
Cdd:cd13131 317 GFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLG 396
|
410 420
....*....|....*....|.
gi 145357859 430 LTMGWIFKFGVKGIWAGMIFG 450
Cdd:cd13131 397 YLLAFTTGLGAFGVWIGLIIG 417
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
40-450 |
9.76e-30 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 120.69 E-value: 9.76e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 40 KKIWYIVGPSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFtLGFNYGLLLGMASALETLCGQAFGAREYYMLGVY 119
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQV-LWLLLVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 120 -MQRYWIILFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISAGVS 198
Cdd:cd13137 80 lGQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 199 LAVHILVCWFFVYGY----KLGI----IGTMASVNVPWWLNIFILFLYSTRGGCTLTWTGFSseaFTGLLELTKLSASSG 270
Cdd:cd13137 160 NVLNIVLDYVLIFGLwgfpGLGVagaaLATVISRVVGALLLLFLLLRGRLPIKISFKGFRLD---RKIIKKLLRIGLPAG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 271 IMLCLENWYYKILMLMTGNLVNAKIAVdsLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLM 350
Cdd:cd13137 237 LEQLLRSLGFLVLLAIVASYGTAALAA--YQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 351 IGLFFTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCYYLIGLPFGL 430
Cdd:cd13137 315 FMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAY 394
|
410 420
....*....|....*....|
gi 145357859 431 TMGWIFKFGVKGIWAGMIFG 450
Cdd:cd13137 395 LLGFVLGLGLTGIWLAMFVD 414
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
47-450 |
2.36e-24 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 105.10 E-value: 2.36e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 47 GPSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFTLGFnYGLLLGMASALETLCGQAFGAREYYMLGVYMQRY-WI 125
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALL-IALGVGLSVGTSALISQAIGAGDEEKARRVLVQSiVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 126 ILFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISAGVSLAVHILV 205
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 206 CWFFVYGY---KLGIIGTMASVNVPWWLNIFILFLYSTRGG-CTLTWTGFSSEAFTGLLELTKLSASSGIMLCLENWYYK 281
Cdd:cd12082 161 DPLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRKGKkILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 282 ILMLMTGNLVNAkIAVDSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLMIGLFFTVIIVI 361
Cdd:cd12082 241 IIVAIVAAFGGA-AALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 362 FHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCYYLIGLPFGLTMGWIFkFGVK 441
Cdd:cd12082 320 FPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLG-LGLY 398
|
....*....
gi 145357859 442 GIWAGMIFG 450
Cdd:cd12082 399 GIWLALVIS 407
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
48-453 |
1.51e-22 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 99.89 E-value: 1.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 48 PSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFTLG---FNYGLLLgmasALETLCGQAFGAREYYMLG-VYMQRY 123
Cdd:PRK01766 20 PILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIWLPvilFGHGLLL----ALTPIVAQLNGAGRRERIAhQVRQGL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 124 WIILFLCCILLLPMYLFATPILKFIGQSDDIAELTG---TIALWVIPvhfAFAFFFPLNRFLQCQLKNKVIAISAGVSLA 200
Cdd:PRK01766 96 WLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVgylHALLWGIP---AYLLYQVLRSFIDGLGKTKPTMVIGFLGLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 201 VHILVCWFFVYGY----KLGIIGT-MASVNVpWWLNIFILFLYSTRGG---CTLTWTGFSSEAFTGLLELTKLSASSGIM 272
Cdd:PRK01766 173 INIPLNYIFIYGKfgfpELGGVGCgVATAIV-YWVMFLAMLIYIKRARrfrDFRLFKGLYKPDWAVIKRLLKLGLPIGLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 273 LCLENWYYKILMLMTGNLVNAKIAvdSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLMIG 352
Cdd:PRK01766 252 IFFEVSLFAVVTLLVSPLGTVTVA--AHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLAVGLGMA 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 353 LFFTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCYYLIGLPFGLTM 432
Cdd:PRK01766 330 LLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGLPLGYIL 409
|
410 420
....*....|....*....|.
gi 145357859 433 GWIFKFGVKGIWAGMIFGGTA 453
Cdd:PRK01766 410 ALTDPMGPFGFWIGLIIGLTA 430
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
269-429 |
4.72e-22 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 92.63 E-value: 4.72e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 269 SGIMLCLENWYYKILMLMTGNLvnAKIAVDSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLS 348
Cdd:pfam01554 2 IALENLLQSLYSLIDTLFVGHL--GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 349 LMIGLFFTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCyYLIGLPF 428
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPL 158
|
.
gi 145357859 429 G 429
Cdd:pfam01554 159 N 159
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
48-208 |
1.41e-21 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 91.09 E-value: 1.41e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 48 PSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFTLGFnYGLLLGMASALETLCGQAFGAREYYMLGVYMQR-YWII 126
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQgLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 127 LFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISAGVSLAVHILVC 206
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 145357859 207 WF 208
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
39-449 |
5.24e-20 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 92.20 E-value: 5.24e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 39 TKKIWYIVGPSIFTGLATYSILIITQAFAGHLGDLELAAISI--INNFTLgfnYGLLLGMASALETLCGQAFGAREYYML 116
Cdd:cd13133 4 YREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPagVLYFAI---LMLFFGLSSGVQVFVAQYNGAGRYSRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 117 GVYMQRYWIILFLCCILLLPMYLFATP-ILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISA 195
Cdd:cd13133 81 GRVLWQGLYFSLLLAPLLALLSALAAPlLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVAN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 196 GVSLAVHILVCWFFVYGY----KLGI----IGTMASvnvpWWLNIFILFLYSTRGG-----CTLTWTGFSSEAFTGLLel 262
Cdd:cd13133 161 LVMVVVNIVLDYALIFGKlgfpAMGIagaaIATVIA----EAVSLLFFLLLLFRRKnrrrfGLRRAWRFDRELLRRIL-- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 263 tKLSASSGIMLCLENWYYKILMLMTGNLVNAKIAVdsLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATI 342
Cdd:cd13133 235 -RLGLPSGLQFFLDVGAFTVFFLLIGRLGTTELAA--TNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 343 VSITLSLMIGLFFTVIIVIFHDQIGSIFS---SSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLG 419
Cdd:cd13133 312 RGLKLALAYMLLLGILFLLFPELLLSIFTpgaDFALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELI 391
|
410 420 430
....*....|....*....|....*....|
gi 145357859 420 CYYLIGLPFGLTMGWiFKFGVKGIWAGMIF 449
Cdd:cd13133 392 VAWLYLLPPAYLLVV-LGAGLAGAWTVETV 420
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
39-449 |
1.96e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 81.39 E-value: 1.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 39 TKKIWYIVGPSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFTLGFNYgLLLGMASALETLCGQAFGAREYYMLG- 117
Cdd:cd13134 2 KLSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLIL-IFSFISTGTSILIAQYLGAKDKKKARq 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 118 VYMQRYWIILFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISAGV 197
Cdd:cd13134 81 IAGVALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 198 SLAVHILVCWFFVYGY----KLGIIGTMASVNVPWWLNIFILFLYSTRGgctLTWTGFSSEAFTGLLELTKLSASSGIML 273
Cdd:cd13134 161 MNILNIVGNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLFRK---LKIRFRLKDLRPFPKKLLKKILKIGLPS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 274 CLENWYYKILMLMTGNLVNA--KIAVDSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLMI 351
Cdd:cd13134 238 AGEELSYNLSQTVITAFIARlgTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 352 GLFFTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCYYLIGLPFGLT 431
Cdd:cd13134 318 SLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYL 397
|
410
....*....|....*...
gi 145357859 432 MGWIFKFGVKGIWAGMIF 449
Cdd:cd13134 398 LGIVLGLGLLGVWIAFAA 415
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
65-450 |
2.34e-16 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 80.97 E-value: 2.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 65 AFAGH-LGDLELAAISIINNFTLGFNyGLLLGMASALETLCGQAFGAREYYMLG-VYMQRYWIILFLCCILLLPMYLFAT 142
Cdd:cd13138 28 LIVGQfLGVAALAAVSNGSPIIFLLT-AIGMGLSMGGTILISQYIGAKDEEKAKkAVGTLLVLFLILGIVLTILGLLFAP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 143 PILKFIGQSDDIAELT---GTIALWVIPVHFAFAFFfplNRFLQCQLKNKVIAISAGVSLAVHILVCWFFVYGYKLGIIG 219
Cdd:cd13138 107 PILRLMNTPAEILELAvsyLRICFLGIPFIFGYNAY---SAILRGLGDSKTPLYFVIIACVLNIILDLLFIAVFHMGVAG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 220 T-MASVNVPWWLNIF-ILFLYSTRGGCTLTWTGFSSEAFTgLLELTKLSASSGIMLCLENwyykILMLMTGNLVNA--KI 295
Cdd:cd13138 184 AaLATVIAQAISVLLaLYYLRKKKLPFKLSLKDFRFDKEI-LKEILKIGLPSALQQSLVS----ISFLIINSIVNSygVV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 296 AVDSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLMIGLFFTVIIVIFHDQIGSIFSSSEA 375
Cdd:cd13138 259 ASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPE 338
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145357859 376 VLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCYYLIGLPFGLTMGWIFKFGVKGIWAGMIFG 450
Cdd:cd13138 339 VIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPIS 413
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
40-447 |
1.21e-14 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 75.62 E-value: 1.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 40 KKIWYIVGPSIFTGLATYSILIITQAFAGHL-GDLELAAISIIN---NFTLGFnyGLLLGMASAleTLCGQAFGAREYYM 115
Cdd:cd13143 4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFpiiMLLMAL--GLMIGVGGA--SLISRRLGAGDREK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 116 LGVYM-QRYWIILFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAIS 194
Cdd:cd13143 80 ANRIFsTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 195 AGVSLAVHILVCWFFVYGYKLGI--------IGTMASVnvpwwlniFILFLYSTRGGCTLTWT-GFSSEAFTGLLELTKL 265
Cdd:cd13143 160 MLIGAVLNIILDPLFIFVLGLGIagaalatvIAQLISL--------LLLLLYFFRGKSLLKLSlLRFKLSLKIIKEILAL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 266 SASSGIM---LCLENWYYKILMLMTGNlvnaKIAVDSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATI 342
Cdd:cd13143 232 GFPSFLMqlsSSVVTIVLNLTLLGYGG----DIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALK 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 343 VSITLSLMIGLFFTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCYY 422
Cdd:cd13143 308 LALIVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQG 387
|
410 420
....*....|....*....|....*
gi 145357859 423 LIGLPFGLTMGWIfkFGVKGIWAGM 447
Cdd:cd13143 388 LFLIPLLLILPRL--FGLDGIWLAF 410
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
36-238 |
1.83e-11 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 65.94 E-value: 1.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 36 WIETKKIWYIVGPSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFtLGFNYGLLLGMASALETLCGQAFGAREYYM 115
Cdd:COG0534 225 RKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRI-ESLAFMPALGLGQAAQPLVGQNLGAGDYDR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 116 LGVYMQR-YWIILFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAIS 194
Cdd:COG0534 304 ARRAARLaLLLALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMII 383
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 145357859 195 AGVSLAVHILVCWFFVYGYKLGIIGTMASVNVPWWLNIFILFLY 238
Cdd:COG0534 384 SLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
68-448 |
4.33e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 64.91 E-value: 4.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 68 GHLGDLELAAISIINNFTLGFnYGLLLGMASALETLCGQAFGAREYYMLGVYM-QRYWIILFLCCILLLPMYLFATPIL- 145
Cdd:cd13142 39 GRLGADAVAAPSISWPLIFLF-ISLGGGLTVAGTALVAQYTGAGDYDKANKVAgQTFSFVIILSLILAVLGYILSRPLLl 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 146 KFIGQSDDIAELTgTIALWVIPVHFAFAF-FFPLNRFLQCQLKNKVIAISAGVSLAVHILVCWFFVYGY----KLGIIG- 219
Cdd:cd13142 118 LLIGAPEEVYPLA-LAYLRIIFLGLPFMFiFFVFNSLLRGIGDTKTPMKIMFGSVLLNVILDPLLIFGIgpfpGLGVAGa 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 220 ---TMASVNVPWWLNIFILFlySTRGGCTLTWTGFSSEAFTgLLELTKLSASSGIMLCLENWYYKILMLMTGNLvnAKIA 296
Cdd:cd13142 197 alaTVISRGIAAVIGLYLLF--KGRVGLKISLRDLKPDWEW-LKKIFRIGLPSSIEQSARALGFTVMTALVAGF--GTVV 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 297 VDSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLMIGLFFTVIIVIFHDQIGSIFSSSEAV 376
Cdd:cd13142 272 VAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEV 351
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145357859 377 LNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCYYLIGLPFGLTMGWIFKFGVKGIWAGMI 448
Cdd:cd13142 352 IKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYLLAYVLGLGVTGIWIAMA 423
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
40-449 |
9.15e-11 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 63.73 E-value: 9.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 40 KKIWYIVGPSIFTGLATYSILIITQAFAGHLGDL-ELAAIS----IINNFTLGFNYgllLGMASAleTLCGQAFGAREYY 114
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVAlgttIFNTLFWLFGF---LRMGTT--GLVAQALGAGDRE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 115 -MLGVYMQRYWIILFLCCILLLPMYLFATPILKFIGQSDDIAELTGT---IALWVIP---VHFAFafffplNRFLQCQLK 187
Cdd:cd13136 78 eAIALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQylrIRILGAPavlLNYVA------TGWFRGLQD 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 188 NKVIAISAGVSLAVHILVCWFFVYGYKLGIIGTMASVNVPWWLnIFILFLYSTRGGCTLTWTGFSSEAFTGLLELTKLSA 267
Cdd:cd13136 152 TRTPLILQIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYL-GALLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 268 SSGIM---LCLenwyykILMLMTGNLVNAKIAVDSLS---ICMSVNgweMMIPLAF--FAGTG-VRVANELGAGNGKGAR 338
Cdd:cd13136 231 NRDIFirtLAL------LAAFLFFTALAARLGDVILAanqILLQFW---LLSSYFLdgFAYAAeALVGRALGAGDRKAAR 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 339 FATIVSITLSLMIGLFFTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINL 418
Cdd:cd13136 302 RVARRLLQWGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSML 381
|
410 420 430
....*....|....*....|....*....|.
gi 145357859 419 GCyYLIGLPFGLTMGWIfkFGVKGIWAGMIF 449
Cdd:cd13136 382 VS-LAVFLPLLFLLVPL--WGNHGLWLALIL 409
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
40-450 |
4.68e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 51.91 E-value: 4.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 40 KKIWYIVGPSIFTGLATYSILIITQAFAGHLGDLelaAISIINNFTLGFN--YGLLLGMASALETLCGQAFGAREYYMLG 117
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIR---YYSAVGNVTTPFNtiTGFLGSISIGFTILGSQSVGAKDIKRIN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 118 VYMQRYWIILFLCCILLLPMYLF-ATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISAG 196
Cdd:cd13135 78 DYAISSIVYNSIIGVILFLLWLFgARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 197 VSLAVHILVCWFFVYGY----KLGIIGTMASVNVPWWLNIFILFLYStRGGCTLTWTGFSSEAFTGLLELTKLSASSGIM 272
Cdd:cd13135 158 IKNLLNVILDYVLIFGNfgfpRLGIIGAAIATTIANVLNLIILVYLC-RKIKKLTFKLSNTKVLKANIRPYKFTIKLGLP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 273 LCLENWYYKILMLMTGNLVNA--KIAVDSLSICMSVNGWEMMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLM 350
Cdd:cd13135 237 LGGEEFLWNIGNLAVIRILNRigELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 351 IGLFFTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCyYLIGLPFGL 430
Cdd:cd13135 317 IYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIG-TIIVVSVAL 395
|
410 420
....*....|....*....|
gi 145357859 431 TMGWIFKFGVKGIWAGMIFG 450
Cdd:cd13135 396 LLIFVFKLGLAGVYITLFID 415
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
312-450 |
4.85e-06 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 48.97 E-value: 4.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 312 MIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLMIGLFFTVIIVIFHDQIGSIF------SSSEAVLNAVDNLSV 385
Cdd:PRK00187 286 MVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGAVVMLLFAGLFWLLPEAIIGLFldrndpAFAEIVQLAVSLLAV 365
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145357859 386 LLAFTvLLNSVQPVLSGVAVGSGWQSYVAYINLGCYYLIGLPFGLTMGWIFKFGVKGIWAGMIFG 450
Cdd:PRK00187 366 AAWFE-LFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALG 429
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
36-242 |
8.09e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 44.76 E-value: 8.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 36 WIETKKIWYIVGPSIFTGLATYSILIITQAFAGHLGDLELAAISIINNFTlGFNYGLLLGMASALETLCGQAFGAREYY- 114
Cdd:cd13138 221 KEILKEILKIGLPSALQQSLVSISFLIINSIVNSYGVVASAAYGIANKIN-SFAFLPPSAIGQAVSTFVAQNIGAGKIEr 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 115 MLGVYMQRYWIILFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQ-CQLKNKVIAI 193
Cdd:cd13138 300 AKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRgLGKTKFPMII 379
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 145357859 194 SAGVSLAVHILVCWFFVYGYKLGIIGTMASVNVPWWLNIFILFLYSTRG 242
Cdd:cd13138 380 SILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKG 428
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
320-408 |
1.22e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 44.44 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 320 GTGVRVANELGAGNGKGARFATIVSITLSLMIGLFFTVIIVIFHDQIGSIF--SSSEAVLNAVDNLSVlLAFTVLLNSVQ 397
Cdd:cd13140 63 GAQVKVSQSIGAKDEKEARKYARNALQLNLLLGILYGLLLLLFAKPLIGFFnlGDAEVISLAITYLRI-VALGLIFSFLN 141
|
90
....*....|.
gi 145357859 398 PVLSGVAVGSG 408
Cdd:cd13140 142 PVFTGIFNALG 152
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
319-406 |
4.03e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 42.91 E-value: 4.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 319 AGTGVRVANELGAGNGKGARFATIVSITLSLMIGLFFTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLnsvqp 398
Cdd:cd13147 66 AGASSAISRRIGAKDKEGADNAAVHSILLGLIISIILTIVLLPFLEPILVLMGAGEVLDLAVDYGRIIFLGSIFL----- 140
|
....*...
gi 145357859 399 VLSGVAVG 406
Cdd:cd13147 141 IFNNVAYG 148
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
40-237 |
7.08e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 42.10 E-value: 7.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 40 KKIWYIVGPSIFTGLA-TYSILIITqAFAGHLGDLELAAISIINNFTLgFNYGLLLGMASALETLCGQAFGAREYYMLGV 118
Cdd:cd13134 228 KKILKIGLPSAGEELSyNLSQTVIT-AFIARLGTAALAARTYASNISM-FVFLFSLAIGQATQIIVGHLVGAGDFDEAYK 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 119 YMQRYWII-LFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISAGV 197
Cdd:cd13134 306 RVLKSLKIgLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGII 385
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 145357859 198 SL-AVHILVCWFFVYGYKLGIIGTMASVNVPWWLNIFILFL 237
Cdd:cd13134 386 SMwGISVPLAYLLGIVLGLGLLGVWIAFAADEWVRGIIMLW 426
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
39-447 |
7.25e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 41.74 E-value: 7.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 39 TKKIWYIVGPSIFTGLATYSILIITQAFAGHLGDLELAAISIiNNFTLGFNYGLLLGMASALETLCGQAFGAREYYMLGV 118
Cdd:cd13140 4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGT-AGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 119 YMQR-YWIILFLCCILLLPMYLFATPILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFP-LNRFLQCQLKNKVIAISAG 196
Cdd:cd13140 83 YARNaLQLNLLLGILYGLLLLLFAKPLIGFFNLGDAEVISLAITYLRIVALGLIFSFLNPvFTGIFNALGDSKTPFIINA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 197 VSLAVHILVCWFFVYGY----KLGIIGTMASVNVPWWLnIFILFLYSTRG--GCTLTWTGFSSEAFTGLLELTKLSASSG 270
Cdd:cd13140 163 IGLVLNIILDPLLIFGFgpfpALGVAGAALATVLAQAI-VFLLFLYALKKkkGLFLKIRILKRPDRKYIKEILKLGLPVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 271 IMLCLENWYYKILMLMTGNLVNAKIAVDSL-----SIC-MSVNGwemmiplaFFAGTGVRVANELGAGNGKGARFATIVS 344
Cdd:cd13140 242 LQSILFALISMILARIIASFGPVAIAAQKVgsqieSISwMTAEG--------FSTALAAFVGQNYGAGKYDRIRKGYKTA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 345 ITLSLMIGLFFTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQPVLSGVAVGSGWQSYVAYINLGCyYLI 424
Cdd:cd13140 314 LKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISIVF-NGL 392
|
410 420
....*....|....*....|...
gi 145357859 425 GLPFGLTMGWiFKFGVKGIWAGM 447
Cdd:cd13140 393 RIPLALLLSP-TGLGLNGIWWAI 414
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
322-444 |
1.71e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 40.67 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 322 GVRVANELGAGNGKGARFATIVSITLSLMIGLFFTVIIVIFHDQIGSIFSSSEAV-LNAVDNLSVL-LAFTVLLNSVqpV 399
Cdd:cd13139 299 ATLVGQNLGAGQPDRAEKSVWRAGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEViAIAVEALRIIsLGYIFYGYGM--V 376
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 145357859 400 LSGVAVGSGWQSYVAYINLGCYYLIGLPFGLTMGWIFKFGVKGIW 444
Cdd:cd13139 377 LSQAFNGAGDTKTPTLINLVGFWLFQIPLAYLLARHLNLGPKGVF 421
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
311-453 |
6.01e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 38.82 E-value: 6.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 311 MMIPLAFFAGTGVRVANELGAGNGKGARFATIVSITLSLMIGLFFTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFT 390
Cdd:cd13149 283 FIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIG 362
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145357859 391 VLLNSVQPVLSGVAVGSGWQSYVAYINLGCYYLIGLPFGLTMGWIfkFGVKGIWAG-----MIFGGTA 453
Cdd:cd13149 363 YGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIPLAYVGSHL--LGFAGVFIGalagnLIAGILA 428
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
65-238 |
6.61e-03 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 38.70 E-value: 6.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 65 AFAGHLGDLELAAISIINNFTLGFNYgLLLGMASALETLCGQAFGAREYYMLGVYMQR--YWIILFLCCILLLpMYLFAT 142
Cdd:cd13136 250 ALAARLGDVILAANQILLQFWLLSSY-FLDGFAYAAEALVGRALGAGDRKAARRVARRllQWGLGLGVLLALL-FFLGGE 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 143 PILKFIGQSDDIAELTGTIALWVIPVHFAFAFFFPLNRFLQCQLKNKVIAISAGVSLAVhILVCWFFVYGYkLGIIGTMA 222
Cdd:cd13136 328 PIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSLAV-FLPLLFLLVPL-WGNHGLWL 405
|
170
....*....|....*.
gi 145357859 223 SVNVPWWLNIFILFLY 238
Cdd:cd13136 406 ALILFMLLRGLTLALR 421
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
330-453 |
9.33e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 38.29 E-value: 9.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357859 330 GAGNGKGARFATIVSITLSLMIGLFFTVIIVIFHDQIGSIFSSSEAVLNAVDNLSVLLAFTVLLNSVQP--VLSGV---A 404
Cdd:cd13147 299 GARNYEKLKTAYNYSIKLGLIIELIIAILIFIFAPQIAYLFTYSEESAHLAPEIVAFLRIMCLFLPFVPfgMMSSSmfqG 378
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 145357859 405 VGSGWQSYVAYI--NLGCYYLIGLPFGLTMGWifkfGVKGIWAGMIFGGTA 453
Cdd:cd13147 379 IGKGLTSLIITIlrELIFQVLFAYLFAIVLGL----GLFGVWWGIVLGNAI 425
|
|
| |
