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Conserved domains on  [gi|15240040|ref|NP_196821|]
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senescence-associated gene 29 [Arabidopsis thaliana]

Protein Classification

SWEET family sugar transporter( domain architecture ID 10503726)

SWEET family sugar transporter similar to plant SWEET bidirectional sugar transporters that mediate both low-affinity uptake and efflux of sugar across the plasma membrane

CATH:  1.20.1280.290
Gene Ontology:  GO:0051119
PubMed:  25988582
SCOP:  3002472

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 134-218 1.62e-25

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


:

Pssm-ID: 397278  Cd Length: 87  Bit Score: 96.88  E-value: 1.62e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240040   134 SVLGWICVAISVSVFAAPLMIVARVIKTKSVEYMPFTLSFFLTISAVMWFAYGLFLNDICIAIPNVVGFVLGLLQMVLYL 213
Cdd:pfam03083   1 FLLGILCVVFTVAMFLSPLSILRKIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFI 80


                  ....*
gi 15240040   214 VYRNS 218
Cdd:pfam03083  81 VYPPK 85
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 12-99 3.39e-24

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


:

Pssm-ID: 397278  Cd Length: 87  Bit Score: 93.41  E-value: 3.39e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240040    12 FIFGILGNVISFLVFLAPVPTFYRIYKRKSTESFQSLPYQVSLFSCMLWLYYALIKKDaFLLITINSFGCVVETLYIAMF 91
Cdd:pfam03083   1 FLLGILCVVFTVAMFLSPLSILRKIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKD-GYIIIPNGIGCFLGTIYLILF 79


                  ....*...
gi 15240040    92 FAYATREK 99
Cdd:pfam03083  80 IVYPPKKA 87
 
Name Accession Description Interval E-value
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 134-218 1.62e-25

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


Pssm-ID: 397278  Cd Length: 87  Bit Score: 96.88  E-value: 1.62e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240040   134 SVLGWICVAISVSVFAAPLMIVARVIKTKSVEYMPFTLSFFLTISAVMWFAYGLFLNDICIAIPNVVGFVLGLLQMVLYL 213
Cdd:pfam03083   1 FLLGILCVVFTVAMFLSPLSILRKIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFI 80


                  ....*
gi 15240040   214 VYRNS 218
Cdd:pfam03083  81 VYPPK 85
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 12-99 3.39e-24

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


Pssm-ID: 397278  Cd Length: 87  Bit Score: 93.41  E-value: 3.39e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240040    12 FIFGILGNVISFLVFLAPVPTFYRIYKRKSTESFQSLPYQVSLFSCMLWLYYALIKKDaFLLITINSFGCVVETLYIAMF 91
Cdd:pfam03083   1 FLLGILCVVFTVAMFLSPLSILRKIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKD-GYIIIPNGIGCFLGTIYLILF 79


                  ....*...
gi 15240040    92 FAYATREK 99
Cdd:pfam03083  80 IVYPPKKA 87
SWEET COG4095
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 155-216 5.71e-06

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


Pssm-ID: 443271  Cd Length: 83  Bit Score: 43.64  E-value: 5.71e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15240040 155 VARVIKTKSVEYMPFTLSFFLTISAVMWFAYGLFLNDICIAIPNVVGFVLGLLQMVLYLVYR 216
Cdd:COG4095  22 VIKTWKTKSTKDISLGMYLIFTTGVALWLIYGILIGDLPIILANAITLVLALIILVLKLRYR 83
SemiSWEET_2 NF037968
SemiSWEET transporter; The SWEET (Sugars Will Eventually be Exported Transporter) is a ...
 155-215 1.08e-04

SemiSWEET transporter; The SWEET (Sugars Will Eventually be Exported Transporter) is a superfamily of sugar transporters found in both eukaryotes and prokaryotes. Eukaryotic SWEETs usually have seven transmembrane helices (TMHs), but most prokaryotic SWEETs (SemiSWEETs) have only three TMHs. Proteins of this family have 3 TMHs.


Pssm-ID: 411573  Cd Length: 76  Bit Score: 39.81  E-value: 1.08e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15240040  155 VARVIKTKSVEYMPFTLSFFLTISAVMWFAYGLFLNDICIAIPNVVGFVLGLLQMVLYLVY 215
Cdd:NF037968  16 VIKTWKTKDTKDISLGMYLVFTTGVALWLIYGILIGDLPIILANAVTLLLAGIILVLKLRY 76
 
Name Accession Description Interval E-value
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 134-218 1.62e-25

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


Pssm-ID: 397278  Cd Length: 87  Bit Score: 96.88  E-value: 1.62e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240040   134 SVLGWICVAISVSVFAAPLMIVARVIKTKSVEYMPFTLSFFLTISAVMWFAYGLFLNDICIAIPNVVGFVLGLLQMVLYL 213
Cdd:pfam03083   1 FLLGILCVVFTVAMFLSPLSILRKIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFI 80


                  ....*
gi 15240040   214 VYRNS 218
Cdd:pfam03083  81 VYPPK 85
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 12-99 3.39e-24

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


Pssm-ID: 397278  Cd Length: 87  Bit Score: 93.41  E-value: 3.39e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240040    12 FIFGILGNVISFLVFLAPVPTFYRIYKRKSTESFQSLPYQVSLFSCMLWLYYALIKKDaFLLITINSFGCVVETLYIAMF 91
Cdd:pfam03083   1 FLLGILCVVFTVAMFLSPLSILRKIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKD-GYIIIPNGIGCFLGTIYLILF 79


                  ....*...
gi 15240040    92 FAYATREK 99
Cdd:pfam03083  80 IVYPPKKA 87
SWEET COG4095
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 155-216 5.71e-06

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


Pssm-ID: 443271  Cd Length: 83  Bit Score: 43.64  E-value: 5.71e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15240040 155 VARVIKTKSVEYMPFTLSFFLTISAVMWFAYGLFLNDICIAIPNVVGFVLGLLQMVLYLVYR 216
Cdd:COG4095  22 VIKTWKTKSTKDISLGMYLIFTTGVALWLIYGILIGDLPIILANAITLVLALIILVLKLRYR 83
SemiSWEET_2 NF037968
SemiSWEET transporter; The SWEET (Sugars Will Eventually be Exported Transporter) is a ...
 155-215 1.08e-04

SemiSWEET transporter; The SWEET (Sugars Will Eventually be Exported Transporter) is a superfamily of sugar transporters found in both eukaryotes and prokaryotes. Eukaryotic SWEETs usually have seven transmembrane helices (TMHs), but most prokaryotic SWEETs (SemiSWEETs) have only three TMHs. Proteins of this family have 3 TMHs.


Pssm-ID: 411573  Cd Length: 76  Bit Score: 39.81  E-value: 1.08e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15240040  155 VARVIKTKSVEYMPFTLSFFLTISAVMWFAYGLFLNDICIAIPNVVGFVLGLLQMVLYLVY 215
Cdd:NF037968  16 VIKTWKTKDTKDISLGMYLVFTTGVALWLIYGILIGDLPIILANAVTLLLAGIILVLKLRY 76
PQ-loop pfam04193
PQ loop repeat; Members of this family are all membrane bound proteins possessing a pair of ...
 13-61 5.13e-03

PQ loop repeat; Members of this family are all membrane bound proteins possessing a pair of repeats each spanning two transmembrane helices connected by a loop. The PQ motif found on loop 2 is critical for the localization of cystinosin to lysosomes. However, the PQ motif appears not to be a general lysosome-targeting motif. It is thought likely to possess a more general function. Most probably this involves a glutamine residue. Family members are membrane transporters since two members, cystinosin and PQLC2, transport cystine and cationic amino acids, respectively, across the lysosomal membrane. The 2nd PQ-loop of cystinosin hosts the substrate-coupled H+ binding site underlying its H+ symport mechanism, suggesting that PQ-loop repeats have functional significance. It is thus likely that PQ-loop-containing proteins act as a family of membrane transporters. Some transport cystine and cationic amino acids, respectively, across the lysosomal membrane. Others transport lysine and or arginine across the lysosomal membrane in order to maintain the acidic homoeostasis.


Pssm-ID: 461220 [Multi-domain]  Cd Length: 61  Bit Score: 34.79  E-value: 5.13e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 15240040    13 IFGILGNVISFLVFLAPVPTFYRIYKRKSTESFqslpyqvSLFSCMLWL 61
Cdd:pfam04193   1 LSNVLGYISLVLWLVSYLPQIIKNYKRKSTEGL-------SILFLLLWL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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