|
Name |
Accession |
Description |
Interval |
E-value |
| CRM1 |
COG5101 |
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ... |
4-1044 |
0e+00 |
|
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];
Pssm-ID: 227432 [Multi-domain] Cd Length: 1053 Bit Score: 983.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 4 EKLRDLSQPIDVGVLDATVAAFFvTGSKEERAAADQILRDLQANPDMWLQVVHILQNTNSLDTKFFALQVLEGVIKYRWN 83
Cdd:COG5101 2 EGILEFDKDLDIALLDKVVTTFY-QGDGRKQEQAQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLITTKWK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 84 ALPVEQRDGMKNYISEVIVQLSSNEASFRSERLYVNKLNVILVQIVKHDWPAKWTSFIPDLVAAAKTSETICENCMAILK 163
Cdd:COG5101 81 LLPEGMRQGIRNYVVQLVIEKSQDDKVRDKQKYVLNKLDLTLVQILKQEWPRNWPTFIPELINVSQISMEVCENNMIVLK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 164 LLSEEVFDFSRGEMTQQKIKELKQSLNSEFKLIHELCLYVLSASQRQDLIRATLSALHAYLSWIPLGYIFESTLLETLL- 242
Cdd:COG5101 161 LLSEEVFDFSAEQMTQVKKRLLKNQMKIEFPQIFGLCKQILEYSRDESLIEATLESLLRFLEWIPLDYIFETNIIELVLe 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 243 KFFPVPAYRNLTIQCLTEVAALNFGDFYNVQYVKMYTIFiGQLRI------ILPPSTKIPEAYSSGSGEEQAFIQNLALF 316
Cdd:COG5101 241 HFNSMPDTRVATLSCLTEIVDLGRHPQENAEKERILVIH-FQCIEflkmysNKPQEEDIYEVYGGMDKNEQIFVQKLAQF 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 317 FTSFFKFHIRVLEStPEVVSLLLAGLEYLINISYVDDTEVFKVCLDYWNSLVLELFdahhnSDNPAVSASLMG--LQPFL 394
Cdd:COG5101 320 LSSLYEVYISLLEA-REMAENLLNAHGYLIQISRINEREIFKTALEYWNKLVADLY-----SEFQRLPATEMSplIQLSV 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 395 PGMVDGLGSQVMQ----RRQLYSHPMSKLRGLMINRMAKPEEVLIVEDENGNIVRETMKDNDVLVQYKIMRETLIYLSHL 470
Cdd:COG5101 394 GSQAISTNPNQDStkplRKHIYIGILSQLRLVLIENMVRPEEVLIVENDEGEIVREFVKETDTIELYKSMREVLVYLTHL 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 471 DHDDTEKQMLRKLNKQLSGEEWAWNNLNTLCWAIGSISGSMAEDQENRFLVMVIRDLLNLCEITKGKDNKAVIASNIMYV 550
Cdd:COG5101 474 IVDDTEKYMIGKLARQLDGKEWSWNNLNTLCWAIGSISGAMSEVNEKRFFVNVIKDLLALCEMKRGKDNKAVVASNIMYV 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 551 VGQYPRFLRAHWKFLKTVVNKLFEFMHETHPGVQDMACDTFLKIVQKCKRKFVIVQVGENEPFVSELLTGLATTVQDLEP 630
Cdd:COG5101 554 VGQYPRFLKAHWSFLKTVVKKLFEFMHEDHEGVQDMACDTFIKIVQKCPVHFVTQQEGESEPFIVYIIRNLPKTTGDLEP 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 631 HQIHSFYESVGNMIQAESDPQKRDEYLQRLMALPNQKWAEIIGQARHSVEFLKDQVVIRTVLNILQTNTSAATSLGTYFL 710
Cdd:COG5101 634 QQKHTFYEACGMVISEVPKTRDYKRLVLDLMDLPNSAWLNIVIQADENINRLSDTMTVKIDANKMKTNVAKCTSLGYRFY 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 711 SQISLIFLDMLNVYRMYSELVSTNITEGGPYASKTSFVKLLRSVKRETLKLIETFLDKAEDQPHIGKQFVPPMMESVLGD 790
Cdd:COG5101 714 PQTCSSYCIMLFLYFAVSFDISNSVAAEGLIATKTPAVRGLRTIKKEILKLVATYISKARDLKFVQNDLVNMLCEAVLFD 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 791 YARNVPDARESEVLSLFATIINKYKATMLDDVPHIFEAVFQCTLEMITKNFEDYPEHRLKFFSLLRAIATFCFPALIKLS 870
Cdd:COG5101 794 YKNNVPDARDAEVLNLGTTIVRNVESVIYLQRELFLISVFICTLIMIVKDFDEYPEHRKNFLLLLENINLFSFSAFLSFP 873
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 871 SPQLKLVMDSIIWAFRHTERNIAETGLNLLLEMLKNF--QQSEFCNQFYRSYFMQIEQEIFAVLTDTFHKPGFKLHVLVL 948
Cdd:COG5101 874 QPSFKLVYNTILWSFKHINRDVSDLGLNILLILFKNCheMGVPFINQFYAQYYMSTLENILGVLTDSDHKSGFDQQCLLL 953
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 949 QQLFCLPESGALTEPLWDATTvpypypDNVAFVREYTIKLLSSSFPNMTAAEVTQFVNGLYESRNDPSGFKNNIRDFLVQ 1028
Cdd:COG5101 954 AFLIRLVKDNKISVPLYDGIN------PNITILSEYIVGLFVKSFPNITQESVKIFSVGLFELCGDDEIFKEHVEDFRVK 1027
|
1050 1060
....*....|....*....|
gi 15237894 1029 SKEF----SAQDNKDLYAEE 1044
Cdd:COG5101 1028 VYEFgtdeDLQEEIDLKNER 1047
|
|
| CRM1_C |
pfam08767 |
CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins ... |
712-1033 |
3.68e-166 |
|
CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat.
Pssm-ID: 430202 Cd Length: 323 Bit Score: 491.75 E-value: 3.68e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 712 QISLIFLDMLNVYRMYSELVSTNITEGGPYASKTSFVKLLRSVKRETLKLIETFLDKAEDQPHIGKQFVPPMMESVLGDY 791
Cdd:pfam08767 1 QLGRIYLDMLNLYRAYSELISQAVAANGEIATKTPKVRGLRTVKKEILKLIETYISKADDLELVLNNLVPPLLDAVLVDY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 792 ARNVPDARESEVLSLFATIINKYKATMLDDVPHIFEAVFQCTLEMITKNFEDYPEHRLKFFSLLRAIATFCFPALIKLSS 871
Cdd:pfam08767 81 NRNVPDARDAEVLSLMTTIVNKLGNLITDEVPLILDAVFECTLDMINKDFEEYPEHRVNFFKLLRAINLHCFPALLSLPP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 872 PQLKLVMDSIIWAFRHTERNIAETGLNLLLEMLKNFQQ--SEFCNQFYRSYFMQIEQEIFAVLTDTFHKPGFKLHVLVLQ 949
Cdd:pfam08767 161 EQFKLVIDSIVWAFKHTNRDVADTGLNILLELLKNVEEtdSEFANQFYQNYYLSILQEVFYVLTDTDHKSGFKLQALLLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 950 QLFCLPESGALTEPLWDATTVpyPYPDNVAFVREYTIKLLSSSFPNMTAAEVTQFVNGLYESRNDPSGFKNNIRDFLVQS 1029
Cdd:pfam08767 241 RLFRLVENGSITVPLYDPDQA--PGTSNQVFLSEYIANLLQNAFPNLTQEQIEIFVVGLFNLCNDLNKFKSHLRDFLIQL 318
|
....
gi 15237894 1030 KEFS 1033
Cdd:pfam08767 319 KEFG 322
|
|
| CRM1_C |
smart01102 |
CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins ... |
712-1034 |
2.51e-144 |
|
CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat.
Pssm-ID: 198170 Cd Length: 321 Bit Score: 434.88 E-value: 2.51e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 712 QISLIFLDMLNVYRMYSELVSTNITEGGPYASKTSFVKLLRSVKRETLKLIETFLDKAEDQPHIGKQFVPPMMESVLGDY 791
Cdd:smart01102 1 QLGRIYLDMLNLYRAYSELISAAVAKEGTIATKTPKVRGLRTIKREILKLIETYISKAEDLEFVAENFVPPLLEAVLGDY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 792 ARNVPDARESEVLSLFATIINKYKATMLDDVPHIFEAVFQCTLEMITKNFEDYPEHRLKFFSLLRAIATFCFPALIKLSS 871
Cdd:smart01102 81 RRNVPDAREAEVLSLMTTIVNKLGNLLTPEVPLILDAVFECTLDMINKDFEEYPEHRVNFFKLLRAINSHCFPAFLSLPP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 872 PQLKLVMDSIIWAFRHTERNIAETGLNLLLEMLKNFQQ--SEFCNQFYRSYFMQIEQEIFAVLTDTFHKPGFKLHVLVLQ 949
Cdd:smart01102 161 EQFKLVIDSIVWAFKHTDRDVADTGLNILLELLNNVSKkdSQIANEFYKQYYFSILQDIFSVLTDSDHKSGFKLQCLLLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 950 QLFCLPESGALTEPLWDATtvpyPYPDNVAFVREYTIKLLSSSFPNMTAAEVTQFVNGLYESRNDPSGFKNNIRDFLVQS 1029
Cdd:smart01102 241 KLFRLVEENPISVPLYDAP----PGTNNKNFLQEYLANLLSTAFPNLTQEQIKSFVVGLFELNGDDNAFKEHLRDFLIQI 316
|
....*
gi 15237894 1030 KEFSA 1034
Cdd:smart01102 317 KEFGG 321
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CRM1 |
COG5101 |
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ... |
4-1044 |
0e+00 |
|
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];
Pssm-ID: 227432 [Multi-domain] Cd Length: 1053 Bit Score: 983.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 4 EKLRDLSQPIDVGVLDATVAAFFvTGSKEERAAADQILRDLQANPDMWLQVVHILQNTNSLDTKFFALQVLEGVIKYRWN 83
Cdd:COG5101 2 EGILEFDKDLDIALLDKVVTTFY-QGDGRKQEQAQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLITTKWK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 84 ALPVEQRDGMKNYISEVIVQLSSNEASFRSERLYVNKLNVILVQIVKHDWPAKWTSFIPDLVAAAKTSETICENCMAILK 163
Cdd:COG5101 81 LLPEGMRQGIRNYVVQLVIEKSQDDKVRDKQKYVLNKLDLTLVQILKQEWPRNWPTFIPELINVSQISMEVCENNMIVLK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 164 LLSEEVFDFSRGEMTQQKIKELKQSLNSEFKLIHELCLYVLSASQRQDLIRATLSALHAYLSWIPLGYIFESTLLETLL- 242
Cdd:COG5101 161 LLSEEVFDFSAEQMTQVKKRLLKNQMKIEFPQIFGLCKQILEYSRDESLIEATLESLLRFLEWIPLDYIFETNIIELVLe 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 243 KFFPVPAYRNLTIQCLTEVAALNFGDFYNVQYVKMYTIFiGQLRI------ILPPSTKIPEAYSSGSGEEQAFIQNLALF 316
Cdd:COG5101 241 HFNSMPDTRVATLSCLTEIVDLGRHPQENAEKERILVIH-FQCIEflkmysNKPQEEDIYEVYGGMDKNEQIFVQKLAQF 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 317 FTSFFKFHIRVLEStPEVVSLLLAGLEYLINISYVDDTEVFKVCLDYWNSLVLELFdahhnSDNPAVSASLMG--LQPFL 394
Cdd:COG5101 320 LSSLYEVYISLLEA-REMAENLLNAHGYLIQISRINEREIFKTALEYWNKLVADLY-----SEFQRLPATEMSplIQLSV 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 395 PGMVDGLGSQVMQ----RRQLYSHPMSKLRGLMINRMAKPEEVLIVEDENGNIVRETMKDNDVLVQYKIMRETLIYLSHL 470
Cdd:COG5101 394 GSQAISTNPNQDStkplRKHIYIGILSQLRLVLIENMVRPEEVLIVENDEGEIVREFVKETDTIELYKSMREVLVYLTHL 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 471 DHDDTEKQMLRKLNKQLSGEEWAWNNLNTLCWAIGSISGSMAEDQENRFLVMVIRDLLNLCEITKGKDNKAVIASNIMYV 550
Cdd:COG5101 474 IVDDTEKYMIGKLARQLDGKEWSWNNLNTLCWAIGSISGAMSEVNEKRFFVNVIKDLLALCEMKRGKDNKAVVASNIMYV 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 551 VGQYPRFLRAHWKFLKTVVNKLFEFMHETHPGVQDMACDTFLKIVQKCKRKFVIVQVGENEPFVSELLTGLATTVQDLEP 630
Cdd:COG5101 554 VGQYPRFLKAHWSFLKTVVKKLFEFMHEDHEGVQDMACDTFIKIVQKCPVHFVTQQEGESEPFIVYIIRNLPKTTGDLEP 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 631 HQIHSFYESVGNMIQAESDPQKRDEYLQRLMALPNQKWAEIIGQARHSVEFLKDQVVIRTVLNILQTNTSAATSLGTYFL 710
Cdd:COG5101 634 QQKHTFYEACGMVISEVPKTRDYKRLVLDLMDLPNSAWLNIVIQADENINRLSDTMTVKIDANKMKTNVAKCTSLGYRFY 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 711 SQISLIFLDMLNVYRMYSELVSTNITEGGPYASKTSFVKLLRSVKRETLKLIETFLDKAEDQPHIGKQFVPPMMESVLGD 790
Cdd:COG5101 714 PQTCSSYCIMLFLYFAVSFDISNSVAAEGLIATKTPAVRGLRTIKKEILKLVATYISKARDLKFVQNDLVNMLCEAVLFD 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 791 YARNVPDARESEVLSLFATIINKYKATMLDDVPHIFEAVFQCTLEMITKNFEDYPEHRLKFFSLLRAIATFCFPALIKLS 870
Cdd:COG5101 794 YKNNVPDARDAEVLNLGTTIVRNVESVIYLQRELFLISVFICTLIMIVKDFDEYPEHRKNFLLLLENINLFSFSAFLSFP 873
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 871 SPQLKLVMDSIIWAFRHTERNIAETGLNLLLEMLKNF--QQSEFCNQFYRSYFMQIEQEIFAVLTDTFHKPGFKLHVLVL 948
Cdd:COG5101 874 QPSFKLVYNTILWSFKHINRDVSDLGLNILLILFKNCheMGVPFINQFYAQYYMSTLENILGVLTDSDHKSGFDQQCLLL 953
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 949 QQLFCLPESGALTEPLWDATTvpypypDNVAFVREYTIKLLSSSFPNMTAAEVTQFVNGLYESRNDPSGFKNNIRDFLVQ 1028
Cdd:COG5101 954 AFLIRLVKDNKISVPLYDGIN------PNITILSEYIVGLFVKSFPNITQESVKIFSVGLFELCGDDEIFKEHVEDFRVK 1027
|
1050 1060
....*....|....*....|
gi 15237894 1029 SKEF----SAQDNKDLYAEE 1044
Cdd:COG5101 1028 VYEFgtdeDLQEEIDLKNER 1047
|
|
| CRM1_C |
pfam08767 |
CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins ... |
712-1033 |
3.68e-166 |
|
CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat.
Pssm-ID: 430202 Cd Length: 323 Bit Score: 491.75 E-value: 3.68e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 712 QISLIFLDMLNVYRMYSELVSTNITEGGPYASKTSFVKLLRSVKRETLKLIETFLDKAEDQPHIGKQFVPPMMESVLGDY 791
Cdd:pfam08767 1 QLGRIYLDMLNLYRAYSELISQAVAANGEIATKTPKVRGLRTVKKEILKLIETYISKADDLELVLNNLVPPLLDAVLVDY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 792 ARNVPDARESEVLSLFATIINKYKATMLDDVPHIFEAVFQCTLEMITKNFEDYPEHRLKFFSLLRAIATFCFPALIKLSS 871
Cdd:pfam08767 81 NRNVPDARDAEVLSLMTTIVNKLGNLITDEVPLILDAVFECTLDMINKDFEEYPEHRVNFFKLLRAINLHCFPALLSLPP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 872 PQLKLVMDSIIWAFRHTERNIAETGLNLLLEMLKNFQQ--SEFCNQFYRSYFMQIEQEIFAVLTDTFHKPGFKLHVLVLQ 949
Cdd:pfam08767 161 EQFKLVIDSIVWAFKHTNRDVADTGLNILLELLKNVEEtdSEFANQFYQNYYLSILQEVFYVLTDTDHKSGFKLQALLLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 950 QLFCLPESGALTEPLWDATTVpyPYPDNVAFVREYTIKLLSSSFPNMTAAEVTQFVNGLYESRNDPSGFKNNIRDFLVQS 1029
Cdd:pfam08767 241 RLFRLVENGSITVPLYDPDQA--PGTSNQVFLSEYIANLLQNAFPNLTQEQIEIFVVGLFNLCNDLNKFKSHLRDFLIQL 318
|
....
gi 15237894 1030 KEFS 1033
Cdd:pfam08767 319 KEFG 322
|
|
| CRM1_C |
smart01102 |
CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins ... |
712-1034 |
2.51e-144 |
|
CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat.
Pssm-ID: 198170 Cd Length: 321 Bit Score: 434.88 E-value: 2.51e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 712 QISLIFLDMLNVYRMYSELVSTNITEGGPYASKTSFVKLLRSVKRETLKLIETFLDKAEDQPHIGKQFVPPMMESVLGDY 791
Cdd:smart01102 1 QLGRIYLDMLNLYRAYSELISAAVAKEGTIATKTPKVRGLRTIKREILKLIETYISKAEDLEFVAENFVPPLLEAVLGDY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 792 ARNVPDARESEVLSLFATIINKYKATMLDDVPHIFEAVFQCTLEMITKNFEDYPEHRLKFFSLLRAIATFCFPALIKLSS 871
Cdd:smart01102 81 RRNVPDAREAEVLSLMTTIVNKLGNLLTPEVPLILDAVFECTLDMINKDFEEYPEHRVNFFKLLRAINSHCFPAFLSLPP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 872 PQLKLVMDSIIWAFRHTERNIAETGLNLLLEMLKNFQQ--SEFCNQFYRSYFMQIEQEIFAVLTDTFHKPGFKLHVLVLQ 949
Cdd:smart01102 161 EQFKLVIDSIVWAFKHTDRDVADTGLNILLELLNNVSKkdSQIANEFYKQYYFSILQDIFSVLTDSDHKSGFKLQCLLLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 950 QLFCLPESGALTEPLWDATtvpyPYPDNVAFVREYTIKLLSSSFPNMTAAEVTQFVNGLYESRNDPSGFKNNIRDFLVQS 1029
Cdd:smart01102 241 KLFRLVEENPISVPLYDAP----PGTNNKNFLQEYLANLLSTAFPNLTQEQIKSFVVGLFELNGDDNAFKEHLRDFLIQI 316
|
....*
gi 15237894 1030 KEFSA 1034
Cdd:smart01102 317 KEFGG 321
|
|
| Xpo1 |
pfam08389 |
Exportin 1-like protein; The sequences featured in this family are similar to a region close ... |
114-258 |
1.57e-44 |
|
Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.
Pssm-ID: 462459 Cd Length: 147 Bit Score: 157.77 E-value: 1.57e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 114 ERLYVNKLNVILVQIVKHDWPAKWTSFIPDLVAAAKTSETICENCMAILKLLSEEVFDFSRGEMTQQKIKELKQSLNSEF 193
Cdd:pfam08389 1 PKFIRNKLALALAELAKQEYPNNWPTFFPDLISLLSSNPTGCELFLRILKVLPEEIFDFSRTSLTQDRNNRLKDLLRSNM 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15237894 194 KLIHELCLYVLSASQ--RQDLIRATLSALHAYLSWIPLGYIFESTLLETLLKFFPVPAYRNLTIQCL 258
Cdd:pfam08389 81 EQILELLLQILEASQnaNSELVEAVLKCLGSWLSWIPIGLIVNNPLLNLLFSLLNDPDLREAAVECL 147
|
|
| CRM1_repeat_2 |
pfam18784 |
CRM1 / Exportin repeat 2; Chromosome region maintenance 1 / Exportin 1 mediates the nuclear ... |
408-475 |
2.12e-36 |
|
CRM1 / Exportin repeat 2; Chromosome region maintenance 1 / Exportin 1 mediates the nuclear transport of proteins bearing a leucin-rich nuclear export signal (NES). It contains helical repeats that are structurally similar to HEAT repeats, but share little sequence similarity with them. N-, C-terminal and central repeats show slightly different structural arrangements, with N- and C- terminal repeats interacting with each other. This Pfam entry includes some CRM1 repeats that fail to be detected with the pfam18777 model.
Pssm-ID: 436735 Cd Length: 68 Bit Score: 131.45 E-value: 2.12e-36
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15237894 408 RRQLYSHPMSKLRGLMINRMAKPEEVLIVEDENGNIVRETMKDNDVLVQYKIMRETLIYLSHLDHDDT 475
Cdd:pfam18784 1 RRQLYSPILSQLRVVLIERMAKPEEVLIVENEEGEIVREFMKDTDTIALYKSMRETLVYLTHLDPDDT 68
|
|
| CRM1_repeat_3 |
pfam18787 |
CRM1 / Exportin repeat 3; Chromosome region maintenance 1 / Exportin 1 mediates the nuclear ... |
488-538 |
2.52e-30 |
|
CRM1 / Exportin repeat 3; Chromosome region maintenance 1 / Exportin 1 mediates the nuclear transport of proteins bearing a leucin-rich nuclear export signal (NES). It contains helical repeats that are structurally similar to HEAT repeats, but share little sequence similarity with them. N-, C-terminal and central repeats show slightly different structural arrangements, with N- and C- terminal repeats interacting with each other. This Pfam entry includes some CRM1 repeats that fail to be detected with the PF18777 model.
Pssm-ID: 436736 [Multi-domain] Cd Length: 51 Bit Score: 113.43 E-value: 2.52e-30
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 15237894 488 SGEEWAWNNLNTLCWAIGSISGSMAEDQENRFLVMVIRDLLNLCEITKGKD 538
Cdd:pfam18787 1 DGSEWSWNNLNTLCWAIGSISGAMSEEDEKRFLVTVIKDLLNLCEMKRGKD 51
|
|
| CRM1_repeat |
pfam18777 |
Chromosome region maintenance or exportin repeat; Chromosome region maintenance 1 or exportin ... |
337-372 |
1.46e-15 |
|
Chromosome region maintenance or exportin repeat; Chromosome region maintenance 1 or exportin 1 mediates the nuclear transport of proteins bearing a leucin-rich nuclear export signal (NES). It contains helical repeats that are structurally similar to HEAT repeats, but share little sequence similarity with them. N-terminal, C-terminal and central repeats show slightly different structural arrangements, with N- and C- termini repeats interacting with each other. This entry represents the central repeats of CRM1.
Pssm-ID: 465864 [Multi-domain] Cd Length: 37 Bit Score: 70.98 E-value: 1.46e-15
10 20 30
....*....|....*....|....*....|....*.
gi 15237894 337 LLLAGLEYLINISYVDDTEVFKVCLDYWNSLVLELF 372
Cdd:pfam18777 2 LLLAALQYLVKISEVDDREIFKICLEYWNKLVSELY 37
|
|
| IBN_N |
smart00913 |
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ... |
37-103 |
5.14e-15 |
|
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.
Pssm-ID: 197981 [Multi-domain] Cd Length: 67 Bit Score: 70.35 E-value: 5.14e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15237894 37 ADQILRDLQANPDMWLQVVHILQNTNSLDTKFFALQVLEGVIKYRWNALPVEQRDGMKNYISEVIVQ 103
Cdd:smart00913 1 AEKQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
|
|
| IBN_N |
pfam03810 |
Importin-beta N-terminal domain; |
37-103 |
1.51e-11 |
|
Importin-beta N-terminal domain;
Pssm-ID: 397745 [Multi-domain] Cd Length: 72 Bit Score: 60.72 E-value: 1.51e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15237894 37 ADQILRDLQANPDMWLQVVHILQN-TNSLDTKFFALQVLEGVIKYRW----NALPVEQRDGMKNYISEVIVQ 103
Cdd:pfam03810 1 AEKQLEQFEKSPGFWSKLLQILSNsENPLEVRQLAALYLKNLITRHWeeekNSLPPEEKEQIKNNLLNLLGS 72
|
|
| SXM1 |
COG5656 |
Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, ... |
34-321 |
5.53e-05 |
|
Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227943 [Multi-domain] Cd Length: 970 Bit Score: 47.54 E-value: 5.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 34 RAAADQILRDLQANPDMWLQVVHILQNTN-SLDTKFFALQVLEGVIKYRWNAL-----PVEQRDGMKNYISEVIVQLSSN 107
Cdd:COG5656 20 RTIAEAMLKDLEKQPGFVMALLHICSKDEgDLNVKLSAAIYFKNKIIRSWSSKrddgiKADEKSEAKKYLIENILDVFLY 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 108 eaSFRSERLYvnkLNVILVQIVKHDWPAKWTSFIPDLVAAAKTSEtICENCMAILKLlsEEVFDFSRGEM--TQQKIKEL 185
Cdd:COG5656 100 --SPEVTRTA---LNAILVNIFSEDKPSDLWGLFPKAANLLRSSE-ANHVYTGLLCL--EELFKAYRWKYndEQVDILML 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237894 186 KQSL---------NSEFK---LIHELCLYVLSASQRQDL--IRATLSALHAYLSWIPLG-YIFESTLLETLLKFFPVPAY 250
Cdd:COG5656 172 ITALfpilekvggNLESQgnyGSVETLMLILKSFKSVCYysLPDFLSAIETFSSWFQLSlRILQKPLPNEVLSLDPEVRS 251
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15237894 251 RNLTIQC-------LTEVAALNFGDFYNVQYVKMYTIFIGQLRIILPPSTKIPEAYSSGsgeeQAFIQNLALFFTSFF 321
Cdd:COG5656 252 LSKWVKCkkwaaynLYRSFQRYIKKSYKKSYLSFYITFMTRVPMILATFFKQIEEWGQG----QLWLSDIELYFIDFF 325
|
|
| |
