|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00011 |
PLN00011 |
cysteine synthase |
1-323 |
0e+00 |
|
cysteine synthase
Pssm-ID: 177651 Cd Length: 323 Bit Score: 587.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 1 MEDRVLIKNDVTELIGNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGKSTLIEATGGNT 80
Cdd:PLN00011 1 MEDRCLIKNDVTELIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEATAGNT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 81 GIGLASIGASRGYKVILLMPSTMSLERRIILRALGAEVHLTDISIGIKGQLEKAKEILSKTPGGYIPHQFINPENPEIHY 160
Cdd:PLN00011 81 GIGLACIGAARGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGYIPQQFENPANPEIHY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 161 RTTGPEIWRDSAGKVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESAVLSGGKPGPHLIQGIGSGEIPANLDLS 240
Cdd:PLN00011 161 RTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEKNKDIKVCVVEPVESAVLSGGQPGPHLIQGIGSGIIPFNLDLT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 241 IVDEIIQVTGEEAIETTKLLAIKEGLLVGISSGASAAAALKVAKRPENVGKLIVVIFPSGGERYLSTELFESVRYEAENL 320
Cdd:PLN00011 241 IVDEIIQVTGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVIFPSGGERYLSTKLFESVRYEAENL 320
|
...
gi 15241112 321 PVE 323
Cdd:PLN00011 321 PIE 323
|
|
| cysK |
TIGR01139 |
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ... |
11-310 |
1.04e-143 |
|
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273465 Cd Length: 298 Bit Score: 407.14 E-value: 1.04e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 11 VTELIGNTPMVYLNKIvDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGKsTLIEATGGNTGIGLASIGAS 90
Cdd:TIGR01139 1 ISELIGNTPLVRLNRI-EGCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGK-TIVEPTSGNTGIALAMVAAA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 91 RGYKVILLMPSTMSLERRIILRALGAEVHLTDISIGIKGQLEKAKEILSKTPGGY-IPHQFINPENPEIHYRTTGPEIWR 169
Cdd:TIGR01139 79 RGYKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSYfMLQQFENPANPEIHRKTTGPEIWR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 170 DSAGKVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESAVLSGGKPGPHLIQGIGSGEIPANLDLSIVDEIIQVT 249
Cdd:TIGR01139 159 DTDGKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESPVLSGGKPGPHKIQGIGAGFIPKNLNRSVIDEVITVS 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15241112 250 GEEAIETTKLLAIKEGLLVGISSGASAAAALKVAKRPENvGKLIVVIFPSGGERYLSTELF 310
Cdd:TIGR01139 239 DEEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPEP-DKLIVVILPSTGERYLSTPLF 298
|
|
| CysK |
COG0031 |
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ... |
7-307 |
2.71e-143 |
|
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis
Pssm-ID: 439802 [Multi-domain] Cd Length: 301 Bit Score: 405.97 E-value: 2.71e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 7 IKNDVTELIGNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGkSTLIEATGGNTGIGLAS 86
Cdd:COG0031 3 IYDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGLAM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 87 IGASRGYKVILLMPSTMSLERRIILRALGAEVHLTDISIGIKGQLEKAKEILSKTPGGYIPHQFINPENPEIHYRTTGPE 166
Cdd:COG0031 82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTGPE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 167 IWRDSAGKVDILVAgvgtggtvtgtgKFLKEKNKDIKVCVVEPSESAVLSGGKPGPHLIQGIGSGEIPANLDLSIVDEII 246
Cdd:COG0031 162 IWEQTDGKVDAFVAgvgtggtitgvgRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFVPKILDPSLIDEVI 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15241112 247 QVTGEEAIETTKLLAIKEGLLVGISSGASAAAALKVAKRpENVGKLIVVIFPSGGERYLST 307
Cdd:COG0031 242 TVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKR-LGPGKTIVTILPDSGERYLST 301
|
|
| CBS_like |
cd01561 |
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ... |
16-306 |
3.03e-132 |
|
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.
Pssm-ID: 107204 [Multi-domain] Cd Length: 291 Bit Score: 377.62 E-value: 3.03e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 16 GNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGkSTLIEATGGNTGIGLASIGASRGYKV 95
Cdd:cd01561 1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPG-TTIIEPTSGNTGIGLAMVAAAKGYRF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 96 ILLMPSTMSLERRIILRALGAEVHLTDIS--IGIKGQLEKAKEILSKTPGGYIPHQFINPENPEIHYRTTGPEIWRDSAG 173
Cdd:cd01561 80 IIVMPETMSEEKRKLLRALGAEVILTPEAeaDGMKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLDG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 174 KVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESAVLSGGKPGPHLIQGIGSGEIPANLDLSIVDEIIQVTGEEA 253
Cdd:cd01561 160 KVDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGSVLFSGGPPGPHKIEGIGAGFIPENLDRSLIDEVVRVSDEEA 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 15241112 254 IETTKLLAIKEGLLVGISSGASAAAALKVAKRPENvGKLIVVIFPSGGERYLS 306
Cdd:cd01561 240 FAMARRLAREEGLLVGGSSGAAVAAALKLAKRLGP-GKTIVTILPDSGERYLS 291
|
|
| PALP |
pfam00291 |
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ... |
11-269 |
9.84e-59 |
|
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Pssm-ID: 459749 [Multi-domain] Cd Length: 295 Bit Score: 190.60 E-value: 9.84e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 11 VTELIGNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGlitpGKSTLIEATGGNTGIGLASIGAS 90
Cdd:pfam00291 1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGE----GGKTVVEASSGNHGRALAAAAAR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 91 RGYKVILLMPSTMSLERRIILRALGAEVHLTDISigIKGQLEKAKEILSKTPGGYIPHQFINPENPEIhYRTTGPEIWRD 170
Cdd:pfam00291 77 LGLKVTIVVPEDAPPGKLLLMRALGAEVVLVGGD--YDEAVAAARELAAEGPGAYYINQYDNPLNIEG-YGTIGLEILEQ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 171 SAGKVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESAVLSGG---------KPGPHLIQGIGSGEIPANLDLSI 241
Cdd:pfam00291 154 LGGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSlaagrpvpvPVADTIADGLGVGDEPGALALDL 233
|
250 260 270
....*....|....*....|....*....|..
gi 15241112 242 ----VDEIIQVTGEEAIETTKLLAIKEGLLVG 269
Cdd:pfam00291 234 ldeyVGEVVTVSDEEALEAMRLLARREGIVVE 265
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00011 |
PLN00011 |
cysteine synthase |
1-323 |
0e+00 |
|
cysteine synthase
Pssm-ID: 177651 Cd Length: 323 Bit Score: 587.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 1 MEDRVLIKNDVTELIGNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGKSTLIEATGGNT 80
Cdd:PLN00011 1 MEDRCLIKNDVTELIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEATAGNT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 81 GIGLASIGASRGYKVILLMPSTMSLERRIILRALGAEVHLTDISIGIKGQLEKAKEILSKTPGGYIPHQFINPENPEIHY 160
Cdd:PLN00011 81 GIGLACIGAARGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGYIPQQFENPANPEIHY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 161 RTTGPEIWRDSAGKVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESAVLSGGKPGPHLIQGIGSGEIPANLDLS 240
Cdd:PLN00011 161 RTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEKNKDIKVCVVEPVESAVLSGGQPGPHLIQGIGSGIIPFNLDLT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 241 IVDEIIQVTGEEAIETTKLLAIKEGLLVGISSGASAAAALKVAKRPENVGKLIVVIFPSGGERYLSTELFESVRYEAENL 320
Cdd:PLN00011 241 IVDEIIQVTGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVIFPSGGERYLSTKLFESVRYEAENL 320
|
...
gi 15241112 321 PVE 323
Cdd:PLN00011 321 PIE 323
|
|
| PLN02565 |
PLN02565 |
cysteine synthase |
7-323 |
1.50e-162 |
|
cysteine synthase
Pssm-ID: 166206 Cd Length: 322 Bit Score: 455.92 E-value: 1.50e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 7 IKNDVTELIGNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGKSTLIEATGGNTGIGLAS 86
Cdd:PLN02565 5 IAKDVTELIGKTPLVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIGYSMITDAEEKGLIKPGESVLIEPTSGNTGIGLAF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 87 IGASRGYKVILLMPSTMSLERRIILRALGAEVHLTDISIGIKGQLEKAKEILSKTPGGYIPHQFINPENPEIHYRTTGPE 166
Cdd:PLN02565 85 MAAAKGYKLIITMPASMSLERRIILLAFGAELVLTDPAKGMKGAVQKAEEILAKTPNSYILQQFENPANPKIHYETTGPE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 167 IWRDSAGKVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESAVLSGGKPGPHLIQGIGSGEIPANLDLSIVDEII 246
Cdd:PLN02565 165 IWKGTGGKVDAFVSGIGTGGTITGAGKYLKEQNPDIKLYGVEPVESAVLSGGKPGPHKIQGIGAGFIPGVLDVDLLDEVV 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15241112 247 QVTGEEAIETTKLLAIKEGLLVGISSGASAAAALKVAKRPENVGKLIVVIFPSGGERYLSTELFESVRYEAENLPVE 323
Cdd:PLN02565 245 QVSSDEAIETAKLLALKEGLLVGISSGAAAAAAIKIAKRPENAGKLIVVIFPSFGERYLSSVLFESVKKEAENMVFE 321
|
|
| cysK |
TIGR01139 |
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ... |
11-310 |
1.04e-143 |
|
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273465 Cd Length: 298 Bit Score: 407.14 E-value: 1.04e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 11 VTELIGNTPMVYLNKIvDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGKsTLIEATGGNTGIGLASIGAS 90
Cdd:TIGR01139 1 ISELIGNTPLVRLNRI-EGCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGK-TIVEPTSGNTGIALAMVAAA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 91 RGYKVILLMPSTMSLERRIILRALGAEVHLTDISIGIKGQLEKAKEILSKTPGGY-IPHQFINPENPEIHYRTTGPEIWR 169
Cdd:TIGR01139 79 RGYKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSYfMLQQFENPANPEIHRKTTGPEIWR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 170 DSAGKVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESAVLSGGKPGPHLIQGIGSGEIPANLDLSIVDEIIQVT 249
Cdd:TIGR01139 159 DTDGKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESPVLSGGKPGPHKIQGIGAGFIPKNLNRSVIDEVITVS 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15241112 250 GEEAIETTKLLAIKEGLLVGISSGASAAAALKVAKRPENvGKLIVVIFPSGGERYLSTELF 310
Cdd:TIGR01139 239 DEEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPEP-DKLIVVILPSTGERYLSTPLF 298
|
|
| CysK |
COG0031 |
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ... |
7-307 |
2.71e-143 |
|
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis
Pssm-ID: 439802 [Multi-domain] Cd Length: 301 Bit Score: 405.97 E-value: 2.71e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 7 IKNDVTELIGNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGkSTLIEATGGNTGIGLAS 86
Cdd:COG0031 3 IYDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGLAM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 87 IGASRGYKVILLMPSTMSLERRIILRALGAEVHLTDISIGIKGQLEKAKEILSKTPGGYIPHQFINPENPEIHYRTTGPE 166
Cdd:COG0031 82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTGPE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 167 IWRDSAGKVDILVAgvgtggtvtgtgKFLKEKNKDIKVCVVEPSESAVLSGGKPGPHLIQGIGSGEIPANLDLSIVDEII 246
Cdd:COG0031 162 IWEQTDGKVDAFVAgvgtggtitgvgRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFVPKILDPSLIDEVI 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15241112 247 QVTGEEAIETTKLLAIKEGLLVGISSGASAAAALKVAKRpENVGKLIVVIFPSGGERYLST 307
Cdd:COG0031 242 TVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKR-LGPGKTIVTILPDSGERYLST 301
|
|
| cysKM |
TIGR01136 |
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ... |
11-310 |
3.26e-141 |
|
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273463 Cd Length: 299 Bit Score: 400.89 E-value: 3.26e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 11 VTELIGNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGKsTLIEATGGNTGIGLASIGAS 90
Cdd:TIGR01136 1 IEELIGNTPLVRLNRLAPGCDARVLAKLEGFNPSGSVKDRIALSMILDAEKRGLLKPGD-TIIEATSGNTGIALAMVAAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 91 RGYKVILLMPSTMSLERRIILRALGAEVHLTDISIGIKGQLEKAKEILSKTPGGYIPHQFINPENPEIHYRTTGPEIWRD 170
Cdd:TIGR01136 80 RGYKLILTMPETMSLERRKLLRAYGAELILTPGEEGMKGAIDKAEELAAETNKYVMLDQFENPANPEAHYKTTGPEIWRD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 171 SAGKVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESAVLSGGKPGPHLIQGIGSGEIPANLDLSIVDEIIQVTG 250
Cdd:TIGR01136 160 TDGRIDHFVAGVGTGGTITGVGRYLKEQNPNIQIVAVEPAESPVLSGGEPGPHKIQGIGAGFIPKILDLSLIDEVITVSD 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 251 EEAIETTKLLAIKEGLLVGISSGASAAAALKVAKRPENVGKLIVVIFPSGGERYLSTELF 310
Cdd:TIGR01136 240 EDAIETARRLAREEGILVGISSGAAVAAALKLAKRLENADKVIVAILPDTGERYLSTGLF 299
|
|
| PLN03013 |
PLN03013 |
cysteine synthase |
3-323 |
1.15e-137 |
|
cysteine synthase
Pssm-ID: 178587 [Multi-domain] Cd Length: 429 Bit Score: 396.84 E-value: 1.15e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 3 DRVLIKNDVTELIGNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGKSTLIEATGGNTGI 82
Cdd:PLN03013 109 DGLNIADNVSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSVLVEPTSGNTGI 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 83 GLASIGASRGYKVILLMPSTMSLERRIILRALGAEVHLTDISIGIKGQLEKAKEILSKTPGGYIPHQFINPENPEIHYRT 162
Cdd:PLN03013 189 GLAFIAASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDAYMLQQFDNPANPKIHYET 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 163 TGPEIWRDSAGKVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESAVLSGGKPGPHLIQGIGSGEIPANLDLSIV 242
Cdd:PLN03013 269 TGPEIWDDTKGKVDIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVEPTESDILSGGKPGPHKIQGIGAGFIPKNLDQKIM 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 243 DEIIQVTGEEAIETTKLLAIKEGLLVGISSGASAAAALKVAKRPENVGKLIVVIFPSGGeRYLSTELFESVRYEAENLPV 322
Cdd:PLN03013 349 DEVIAISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPENAGKLIAVSLFASG-RDIYTPRCSSLSGKRWRKCS 427
|
.
gi 15241112 323 E 323
Cdd:PLN03013 428 L 428
|
|
| CBS_like |
cd01561 |
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ... |
16-306 |
3.03e-132 |
|
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.
Pssm-ID: 107204 [Multi-domain] Cd Length: 291 Bit Score: 377.62 E-value: 3.03e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 16 GNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGkSTLIEATGGNTGIGLASIGASRGYKV 95
Cdd:cd01561 1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPG-TTIIEPTSGNTGIGLAMVAAAKGYRF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 96 ILLMPSTMSLERRIILRALGAEVHLTDIS--IGIKGQLEKAKEILSKTPGGYIPHQFINPENPEIHYRTTGPEIWRDSAG 173
Cdd:cd01561 80 IIVMPETMSEEKRKLLRALGAEVILTPEAeaDGMKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLDG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 174 KVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESAVLSGGKPGPHLIQGIGSGEIPANLDLSIVDEIIQVTGEEA 253
Cdd:cd01561 160 KVDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGSVLFSGGPPGPHKIEGIGAGFIPENLDRSLIDEVVRVSDEEA 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 15241112 254 IETTKLLAIKEGLLVGISSGASAAAALKVAKRPENvGKLIVVIFPSGGERYLS 306
Cdd:cd01561 240 FAMARRLAREEGLLVGGSSGAAVAAALKLAKRLGP-GKTIVTILPDSGERYLS 291
|
|
| PLN02556 |
PLN02556 |
cysteine synthase/L-3-cyanoalanine synthase |
7-322 |
1.62e-126 |
|
cysteine synthase/L-3-cyanoalanine synthase
Pssm-ID: 178171 [Multi-domain] Cd Length: 368 Bit Score: 366.21 E-value: 1.62e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 7 IKNDVTELIGNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGKSTLIEATGGNTGIGLAS 86
Cdd:PLN02556 49 IKTDASQLIGKTPLVYLNKVTEGCGAYIAAKQEMFQPTSSIKDRPALAMIEDAEKKNLITPGKTTLIEPTSGNMGISLAF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 87 IGASRGYKVILLMPSTMSLERRIILRALGAEVHLTDISIGIKGQLEKAKEILSKTPGGYIPHQFINPENPEIHYRTTGPE 166
Cdd:PLN02556 129 MAAMKGYKMILTMPSYTSLERRVTMRAFGAELVLTDPTKGMGGTVKKAYELLESTPDAFMLQQFSNPANTQVHFETTGPE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 167 IWRDSAGKVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESAVLSGGKPGPHLIQGIGSGEIPANLDLSIVDEII 246
Cdd:PLN02556 209 IWEDTLGQVDIFVMGIGSGGTVSGVGKYLKSKNPNVKIYGVEPAESNVLNGGKPGPHHITGNGVGFKPDILDMDVMEKVL 288
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15241112 247 QVTGEEAIETTKLLAIKEGLLVGISSGASAAAALKVAKRPENVGKLIVVIFPSGGERYLSTELFESVRYEAENL-PV 322
Cdd:PLN02556 289 EVSSEDAVNMARELALKEGLMVGISSGANTVAALRLAKMPENKGKLIVTVHPSFGERYLSSVLFQELRKEAENMqPV 365
|
|
| PRK10717 |
PRK10717 |
cysteine synthase A; Provisional |
7-322 |
1.06e-93 |
|
cysteine synthase A; Provisional
Pssm-ID: 182672 [Multi-domain] Cd Length: 330 Bit Score: 281.36 E-value: 1.06e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 7 IKNDVTELIGNTPMVYLNKIVD--GCvaRIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGKsTLIEATGGNTGIGL 84
Cdd:PRK10717 3 IFEDVSDTIGNTPLIRLNRASEatGC--EILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGG-TIVEGTAGNTGIGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 85 ASIGASRGYKVILLMPSTMSLERRIILRALGAEVHLT------DISIGIKGQLEKAKEILSKTPGGYI-PHQFINPENPE 157
Cdd:PRK10717 80 ALVAAARGYKTVIVMPETQSQEKKDLLRALGAELVLVpaapyaNPNNYVKGAGRLAEELVASEPNGAIwANQFDNPANRE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 158 IHYRTTGPEIWRDSAGKVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESA----VLSG--GKPGPHLIQGIGSG 231
Cdd:PRK10717 160 AHYETTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNPKVKIVLADPTGSAlysyYKTGelKAEGSSITEGIGQG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 232 EIPANLDLSIVDEIIQVTGEEAIETTKLLAIKEGLLVGISSGASAAAALKVAKRpENVGKLIVVIFPSGGERYLSTeLFE 311
Cdd:PRK10717 240 RITANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLARE-LGPGHTIVTILCDSGERYQSK-LFN 317
|
330
....*....|.
gi 15241112 312 SVRYEAENLPV 322
Cdd:PRK10717 318 PDFLREKGLPV 328
|
|
| cysM |
PRK11761 |
cysteine synthase CysM; |
13-312 |
1.90e-82 |
|
cysteine synthase CysM;
Pssm-ID: 236972 Cd Length: 296 Bit Score: 251.33 E-value: 1.90e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 13 ELIGNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGkSTLIEATGGNTGIGLASIGASRG 92
Cdd:PRK11761 8 DTIGNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMIVQAEKRGEIKPG-DTLIEATSGNTGIALAMIAAIKG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 93 YKVILLMPSTMSLERRIILRALGAEVHLTDISIGIKGQLEKAKEiLSKTPGGYIPHQFINPENPEIHYRTTGPEIWRDSA 172
Cdd:PRK11761 87 YRMKLIMPENMSQERRAAMRAYGAELILVPKEQGMEGARDLALQ-MQAEGEGKVLDQFANPDNPLAHYETTGPEIWRQTE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 173 GKVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESAVLSGGK--PGPHLiqgigsgeiPANLDLSIVDEIIQVTG 250
Cdd:PRK11761 166 GRITHFVSSMGTTGTIMGVSRYLKEQNPAVQIVGLQPEEGSSIPGIRrwPEEYL---------PKIFDASRVDRVLDVSQ 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15241112 251 EEAIETTKLLAIKEGLLVGISSGASAAAALKVAKRPENVgkLIVVIFPSGGERYLSTELFES 312
Cdd:PRK11761 237 QEAENTMRRLAREEGIFCGVSSGGAVAAALRIARENPNA--VIVAIICDRGDRYLSTGVFPA 296
|
|
| cysM |
TIGR01138 |
cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of ... |
11-310 |
5.02e-73 |
|
cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of sulfide, to produce cysteine thiosulfonate instead of cysteine. Alternate name: O-acetylserine (thiol)-lyase [Amino acid biosynthesis, Serine family]
Pssm-ID: 130208 [Multi-domain] Cd Length: 290 Bit Score: 227.10 E-value: 5.02e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 11 VTELIGNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGKsTLIEATGGNTGIGLASIGAS 90
Cdd:TIGR01138 2 IEQTVGNTPLVRLQRMGPENGSEVWLKLEGNNPAGSVKDRPALSMIVEAEKRGEIKPGD-VLIEATSGNTGIALAMIAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 91 RGYKVILLMPSTMSLERRIILRALGAEVHLTDISIGIKGQLEKAKEILSKTPGGYIpHQFINPENPEIHYRTTGPEIWRD 170
Cdd:TIGR01138 81 KGYRMKLLMPDNMSQERKAAMRAYGAELILVTKEEGMEGARDLALELANRGEGKLL-DQFNNPDNPYAHYTSTGPEIWQQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 171 SAGKVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESAVLSGgkpgphlIQGIGSGEIPANLDLSIVDEIIQVTG 250
Cdd:TIGR01138 160 TGGRITHFVSSMGTTGTIMGVSRFLKEQNPPVQIVGLQPEEGSSIPG-------IRRWPTEYLPGIFDASLVDRVLDIHQ 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 251 EEAIETTKLLAIKEGLLVGISSGASAAAALKVAKrpENVGKLIVVIFPSGGERYLSTELF 310
Cdd:TIGR01138 233 RDAENTMRELAVREGIFCGVSSGGAVAAALRLAR--ELPDAVVVAIICDRGDRYLSTGVF 290
|
|
| PALP |
pfam00291 |
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ... |
11-269 |
9.84e-59 |
|
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Pssm-ID: 459749 [Multi-domain] Cd Length: 295 Bit Score: 190.60 E-value: 9.84e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 11 VTELIGNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGlitpGKSTLIEATGGNTGIGLASIGAS 90
Cdd:pfam00291 1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGE----GGKTVVEASSGNHGRALAAAAAR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 91 RGYKVILLMPSTMSLERRIILRALGAEVHLTDISigIKGQLEKAKEILSKTPGGYIPHQFINPENPEIhYRTTGPEIWRD 170
Cdd:pfam00291 77 LGLKVTIVVPEDAPPGKLLLMRALGAEVVLVGGD--YDEAVAAARELAAEGPGAYYINQYDNPLNIEG-YGTIGLEILEQ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 171 SAGKVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPSESAVLSGG---------KPGPHLIQGIGSGEIPANLDLSI 241
Cdd:pfam00291 154 LGGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSlaagrpvpvPVADTIADGLGVGDEPGALALDL 233
|
250 260 270
....*....|....*....|....*....|..
gi 15241112 242 ----VDEIIQVTGEEAIETTKLLAIKEGLLVG 269
Cdd:pfam00291 234 ldeyVGEVVTVSDEEALEAMRLLARREGIVVE 265
|
|
| Trp-synth-beta_II |
cd00640 |
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ... |
18-300 |
8.13e-57 |
|
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.
Pssm-ID: 107202 [Multi-domain] Cd Length: 244 Bit Score: 183.87 E-value: 8.13e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 18 TPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLItpGKSTLIEATGGNTGIGLASIGASRGYKVIL 97
Cdd:cd00640 1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKL--PKGVIIESTGGNTGIALAAAAARLGLKCTI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 98 LMPSTMSLERRIILRALGAEVHLTDIsiGIKGQLEKAKEILSKTPGGYIPHQFINPENPEIHYrTTGPEIWRDSAG-KVD 176
Cdd:cd00640 79 VMPEGASPEKVAQMRALGAEVVLVPG--DFDDAIALAKELAEEDPGAYYVNQFDNPANIAGQG-TIGLEILEQLGGqKPD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 177 ILVAGVGTGGTVTGTGKFLKEKNKDIKVCVVEPsesavlsggkpgphliqgigsgeipanldlsivdEIIQVTGEEAIET 256
Cdd:cd00640 156 AVVVPVGGGGNIAGIARALKELLPNVKVIGVEP----------------------------------EVVTVSDEEALEA 201
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 15241112 257 TKLLAIKEGLLVGISSGASAAAALKVAKRPENvGKLIVVIFPSG 300
Cdd:cd00640 202 IRLLAREEGILVEPSSAAALAAALKLAKKLGK-GKTVVVILTGG 244
|
|
| PLN02356 |
PLN02356 |
phosphateglycerate kinase |
8-306 |
2.98e-35 |
|
phosphateglycerate kinase
Pssm-ID: 215204 Cd Length: 423 Bit Score: 132.42 E-value: 2.98e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 8 KNDVTELIGNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLITPGkSTLIEATGGNTGIGLASI 87
Cdd:PLN02356 44 RNGLIDAIGNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKIIEEALESGQLFPG-GVVTEGSAGSTAISLATV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 88 GASRGYKVILLMPSTMSLERRIILRALGAEV------------HLTDIS-----------------IGIKGQL------- 131
Cdd:PLN02356 123 APAYGCKCHVVIPDDVAIEKSQILEALGATVervrpvsithkdHYVNIArrraleanelaskrrkgSETDGIHlektngc 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 132 ----EKAKEILSKT-PGGYIPHQFINPENPEIHYRTTGPEIWRDSAGKVDILVAGVGTGGTVTGTGKFLKEKNKDIKVCV 206
Cdd:PLN02356 203 iseeEKENSLFSSScTGGFFADQFENLANFRAHYEGTGPEIWEQTQGNLDAFVAAAGTGGTLAGVSRFLQEKNPNIKCFL 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 207 VEPSESAVLSG-------------GK----PGPHLIQGIGSGEIPANLDLSIVDEIIQVTGEEAIETTKLLAIKEGLLVG 269
Cdd:PLN02356 283 IDPPGSGLFNKvtrgvmytreeaeGRrlknPFDTITEGIGINRLTQNFLMAKLDGAFRGTDKEAVEMSRYLLKNDGLFVG 362
|
330 340 350
....*....|....*....|....*....|....*..
gi 15241112 270 ISSGASAAAALKVAKRPeNVGKLIVVIFPSGGERYLS 306
Cdd:PLN02356 363 SSSAMNCVGAVRVAQSL-GPGHTIVTILCDSGMRHLS 398
|
|
| Thr-dehyd |
cd01562 |
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ... |
4-268 |
3.28e-11 |
|
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.
Pssm-ID: 107205 [Multi-domain] Cd Length: 304 Bit Score: 62.89 E-value: 3.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 4 RVLIKNDVTElignTPMVY---LNKIVDgcvARIAAKLEMMEPCSSIKDRIAYSMI----KDAEDKGLITpgkstlieAT 76
Cdd:cd01562 8 AARIKPVVRR----TPLLTsptLSELLG---AEVYLKCENLQKTGSFKIRGAYNKLlslsEEERAKGVVA--------AS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 77 GGNTGIGLASIGASRGYKVILLMPSTMSLERRIILRALGAEVHLTDISIGIKgqLEKAKEILSKTpgGYIphqFINPENp 156
Cdd:cd01562 73 AGNHAQGVAYAAKLLGIPATIVMPETAPAAKVDATRAYGAEVVLYGEDFDEA--EAKARELAEEE--GLT---FIHPFD- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 157 eiHYR------TTGPEIWRDsAGKVDIL------------VAGvgtggtvtgtgkFLKEKNKDIKVCVVEPSESAVLS-- 216
Cdd:cd01562 145 --DPDviagqgTIGLEILEQ-VPDLDAVfvpvggggliagIAT------------AVKALSPNTKVIGVEPEGAPAMAqs 209
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15241112 217 --GGKP-----GPHLIQGIGS---GEIPANLDLSIVDEIIQVTGEEAIETTKLLAIKEGLLV 268
Cdd:cd01562 210 laAGKPvtlpeVDTIADGLAVkrpGELTFEIIRKLVDDVVTVSEDEIAAAMLLLFEREKLVA 271
|
|
| IlvA |
COG1171 |
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ... |
18-269 |
2.93e-09 |
|
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440784 [Multi-domain] Cd Length: 327 Bit Score: 57.35 E-value: 2.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 18 TPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMI----KDAEDKGLITpgkstlieATGGNTGIGLASIGASRGY 93
Cdd:COG1171 25 TPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALaslsEEERARGVVA--------ASAGNHAQGVAYAARLLGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 94 KVILLMPSTMSLERRIILRALGAEVHLTDISIgikgQ--LEKAKEILSKTpgGYIphqFINPENPE--IH-YRTTGPEIW 168
Cdd:COG1171 97 PATIVMPETAPAVKVAATRAYGAEVVLHGDTY----DdaEAAAAELAEEE--GAT---FVHPFDDPdvIAgQGTIALEIL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 169 RDsAGKVDIL------------VAGvgtggtvtgtgkFLKEKNKDIKVCVVEPSESAV----LSGGKP----GPHLI-QG 227
Cdd:COG1171 168 EQ-LPDLDAVfvpvggggliagVAA------------ALKALSPDIRVIGVEPEGAAAmyrsLAAGEPvtlpGVDTIaDG 234
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 15241112 228 IGSGEI-PANLDL--SIVDEIIQVTGEEAIETTKLLAIKEGLLVG 269
Cdd:COG1171 235 LAVGRPgELTFEIlrDLVDDIVTVSEDEIAAAMRLLLERTKIVVE 279
|
|
| Thr-synth_1 |
cd01563 |
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ... |
5-175 |
1.99e-08 |
|
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.
Pssm-ID: 107206 [Multi-domain] Cd Length: 324 Bit Score: 54.91 E-value: 1.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 5 VLIKNDVTELIGNTPMVYLNKIVD-GCVARIAAKLEMMEPCSSIKDRIAYSMIKDAedKGLitpGKSTLIEATGGNTGIG 83
Cdd:cd01563 10 VTEDDIVSLGEGNTPLVRAPRLGErLGGKNLYVKDEGLNPTGSFKDRGMTVAVSKA--KEL---GVKAVACASTGNTSAS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 84 LASIGASRGYKVILLMPSTMSLERRIILRALGAEVhltdisIGIKGQLEKAKEI---LSKTPGGYIPHqFINPENPEiHY 160
Cdd:cd01563 85 LAAYAARAGIKCVVFLPAGKALGKLAQALAYGATV------LAVEGNFDDALRLvreLAEENWIYLSN-SLNPYRLE-GQ 156
|
170
....*....|....*
gi 15241112 161 RTTGPEIWRDSAGKV 175
Cdd:cd01563 157 KTIAFEIAEQLGWEV 171
|
|
| PRK08329 |
PRK08329 |
threonine synthase; Validated |
37-153 |
7.92e-07 |
|
threonine synthase; Validated
Pssm-ID: 236244 [Multi-domain] Cd Length: 347 Bit Score: 50.21 E-value: 7.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 37 KLEMMEPCSSIKDRIAYSMIKDAEDKGLitpgKSTLIEATGgNTGIGLASIGASRGYKVILLMPSTMSLERRIILRALGA 116
Cdd:PRK08329 77 KLDYLQPTGSFKDRGTYVTVAKLKEEGI----NEVVIDSSG-NAALSLALYSLSEGIKVHVFVSYNASKEKISLLSRLGA 151
|
90 100 110
....*....|....*....|....*....|....*....
gi 15241112 117 EVHLTDISigikgQLEKAKEILSKTPGGYIPH--QFINP 153
Cdd:PRK08329 152 ELHFVEGD-----RMEVHEEAVKFSKRNNIPYvsHWLNP 185
|
|
| PRK06450 |
PRK06450 |
threonine synthase; Validated |
7-170 |
1.44e-05 |
|
threonine synthase; Validated
Pssm-ID: 180565 [Multi-domain] Cd Length: 338 Bit Score: 46.27 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 7 IKNDVTELIGNTPMVYLNKIvdgcvariAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLitpgkSTLIEATGGNTGIGLAS 86
Cdd:PRK06450 48 IKHFISLGEGRTPLIKKGNI--------WFKLDFLNPTGSYKDRGSVTLISYLAEKGI-----KQISEDSSGNAGASIAA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 87 IGASRGYKVILLMPSTMSLERRIILRALGAEVhltdisIGIKGQLEKAKEILSKTPGGYIPHQFinpeNPEIH--YRTTG 164
Cdd:PRK06450 115 YGAAAGIEVKIFVPETASGGKLKQIESYGAEV------VRVRGSREDVAKAAENSGYYYASHVL----QPQFRdgIRTLA 184
|
....*.
gi 15241112 165 PEIWRD 170
Cdd:PRK06450 185 YEIAKD 190
|
|
| ThrC |
COG0498 |
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ... |
16-168 |
3.43e-05 |
|
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 440264 [Multi-domain] Cd Length: 394 Bit Score: 45.19 E-value: 3.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 16 GNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDR---IAYSMIKDAedkglitpGKSTLIEATGGNTGIGLASIGASRG 92
Cdd:COG0498 65 GGTPLVKAPRLADELGKNLYVKEEGHNPTGSFKDRamqVAVSLALER--------GAKTIVCASSGNGSAALAAYAARAG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 93 YKVILLMPST-MSLERRIILRALGAEVhltdisIGIKGQLEKAKEI---LSKTPGGYiphqFINPENPeihYR-----TT 163
Cdd:COG0498 137 IEVFVFVPEGkVSPGQLAQMLTYGAHV------IAVDGNFDDAQRLvkeLAADEGLY----AVNSINP---ARlegqkTY 203
|
....*
gi 15241112 164 GPEIW 168
Cdd:COG0498 204 AFEIA 208
|
|
| PRK06381 |
PRK06381 |
threonine synthase; Validated |
9-118 |
7.28e-05 |
|
threonine synthase; Validated
Pssm-ID: 235789 Cd Length: 319 Bit Score: 43.93 E-value: 7.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 9 NDVTELIGNTPMV---YLNKIVDgcVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLitpgkSTLIEATGGNTGIGLA 85
Cdd:PRK06381 7 SSEEKPPGGTPLLrarKLEEELG--LRKIYLKFEGANPTGTQKDRIAEAHVRRAMRLGY-----SGITVGTCGNYGASIA 79
|
90 100 110
....*....|....*....|....*....|...
gi 15241112 86 SIGASRGYKVILLMPSTMSLERRIILRALGAEV 118
Cdd:PRK06381 80 YFARLYGLKAVIFIPRSYSNSRVKEMEKYGAEI 112
|
|
| PRK08246 |
PRK08246 |
serine/threonine dehydratase; |
37-121 |
4.00e-04 |
|
serine/threonine dehydratase;
Pssm-ID: 181319 [Multi-domain] Cd Length: 310 Bit Score: 41.48 E-value: 4.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 37 KLEMMEPCSSIKDRIAYSMI--KDAEDKGLITpgkstlieATGGNTGIGLASIGASRGYKVILLMPSTMSLERRIILRAL 114
Cdd:PRK08246 42 KLEHLQHTGSFKARGAFNRLlaAPVPAAGVVA--------ASGGNAGLAVAYAAAALGVPATVFVPETAPPAKVARLRAL 113
|
....*..
gi 15241112 115 GAEVHLT 121
Cdd:PRK08246 114 GAEVVVV 120
|
|
| PRK06815 |
PRK06815 |
threonine/serine dehydratase; |
32-296 |
1.48e-03 |
|
threonine/serine dehydratase;
Pssm-ID: 180709 [Multi-domain] Cd Length: 317 Bit Score: 39.68 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 32 ARIAAKLEMMEPCSSIKDRIAYSMIK----DAEDKGLITpgkstlieATGGNTGIGLASIGASRGYKVILLMPSTMSLER 107
Cdd:PRK06815 35 CEVYLKCEHLQHTGSFKFRGASNKLRllneAQRQQGVIT--------ASSGNHGQGVALAAKLAGIPVTVYAPEQASAIK 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 108 RIILRALGAEVHLTDISiGIKGQLE--KAKEILSKTpggyiphqFINPEN-PEI--HYRTTGPEIWRDSAGKVDILVAGV 182
Cdd:PRK06815 107 LDAIRALGAEVRLYGGD-ALNAELAarRAAEQQGKV--------YISPYNdPQViaGQGTIGMELVEQQPDLDAVFVAVG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 183 GTGGTVTGTGkFLKEKNKDIKV--C----------------VVEPSESAVLSGGKPGphliqGIGSGEIPANLDLSIVDE 244
Cdd:PRK06815 178 GGGLISGIAT-YLKTLSPKTEIigCwpanspslytsleageIVEVAEQPTLSDGTAG-----GVEPGAITFPLCQQLIDQ 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 15241112 245 IIQVTGEEAIETTKLLAIKEGLLVGISSGASAAAALKVAKRPEnvGKLIVVI 296
Cdd:PRK06815 252 KVLVSEEEIKEAMRLIAETDRWLIEGAAGVALAAALKLAPRYQ--GKKVAVV 301
|
|
| PRK08206 |
PRK08206 |
diaminopropionate ammonia-lyase; Provisional |
31-122 |
1.77e-03 |
|
diaminopropionate ammonia-lyase; Provisional
Pssm-ID: 236186 Cd Length: 399 Bit Score: 39.86 E-value: 1.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 31 VAR-IAAKLEMmepcsSIKDrIAYSMIKDAEDKGLItpGKSTLIEATGGNTGIGLASiGASR-GYKVILLMPSTMSLERR 108
Cdd:PRK08206 85 VARlLAEKLGL-----DISE-LSFEELTSGEVREKL--GDITFATATDGNHGRGVAW-AAQQlGQKAVIYMPKGSSEERV 155
|
90
....*....|....
gi 15241112 109 IILRALGAEVHLTD 122
Cdd:PRK08206 156 DAIRALGAECIITD 169
|
|
| PRK06608 |
PRK06608 |
serine/threonine dehydratase; |
1-150 |
2.94e-03 |
|
serine/threonine dehydratase;
Pssm-ID: 235842 [Multi-domain] Cd Length: 338 Bit Score: 38.98 E-value: 2.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241112 1 MEDRVLIKNDVTELIGNTPMVY---LNKIVDgcvARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLItPGKstLIEATG 77
Cdd:PRK06608 7 PQNIAAAHNRIKQYLHLTPIVHsesLNEMLG---HEIFFKVESLQKTGAFKVRGVLNHLLELKEQGKL-PDK--IVAYST 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15241112 78 GNTGIGLASIGASRGYKVILLMPSTMSLERRIILRALGAEVHLTDISIGIKgqlEKAKEilSKTPGGYIPHQF 150
Cdd:PRK06608 81 GNHGQAVAYASKLFGIKTRIYLPLNTSKVKQQAALYYGGEVILTNTRQEAE---EKAKE--DEEQGFYYIHPS 148
|
|
| PRK06194 |
PRK06194 |
hypothetical protein; Provisional |
67-124 |
3.12e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 180458 [Multi-domain] Cd Length: 287 Bit Score: 38.84 E-value: 3.12e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15241112 67 PGKSTLIeaTGGNTGIGL--ASIGASRGYKVILLMPSTMSLERRII-LRALGAEVH--LTDIS 124
Cdd:PRK06194 5 AGKVAVI--TGAASGFGLafARIGAALGMKLVLADVQQDALDRAVAeLRAQGAEVLgvRTDVS 65
|
|
| PRK06110 |
PRK06110 |
threonine dehydratase; |
67-118 |
5.29e-03 |
|
threonine dehydratase;
Pssm-ID: 235699 Cd Length: 322 Bit Score: 38.05 E-value: 5.29e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 15241112 67 PGKSTLIEATGGNTGIGLASIGASRGYKVILLMPSTMSLERRIILRALGAEV 118
Cdd:PRK06110 68 PRVRGVISATRGNHGQSVAFAARRHGLAATIVVPHGNSVEKNAAMRALGAEL 119
|
|
| |
