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Conserved domains on  [gi|15241675|ref|NP_198741|]
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F-box family protein [Arabidopsis thaliana]

Protein Classification

F-box protein( domain architecture ID 10584247)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515
PubMed:  10581972|31898225|11178263
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 4-43 4.98e-07

F-box-like; This is an F-box-like family.


:

Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 45.17  E-value: 4.98e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 15241675     4 EEVLKNVFPLLEGEDLASCMGVCKQWRDIARDDFYWKCQC 43
Cdd:pfam12937   6 DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
 
Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 4-43 4.98e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 45.17  E-value: 4.98e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 15241675     4 EEVLKNVFPLLEGEDLASCMGVCKQWRDIARDDFYWKCQC 43
Cdd:pfam12937   6 DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
 1-40 1.35e-05

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 41.49  E-value: 1.35e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15241675   1 MFSEEVLKNVFPLLEGEDL-ASCMGVCKQWRDIARDDFY--WK 40
Cdd:cd22095   4 QLPEELLRNIFAFLPAEDLyQNISLVCRHWRDIVSDPLFipWK 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
4-40 3.58e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 34.33  E-value: 3.58e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 15241675      4 EEVLKNVFPLLEGEDLASCMGVCKQWRDIARDDFYWK 40
Cdd:smart00256   3 DEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
 
Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 4-43 4.98e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 45.17  E-value: 4.98e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 15241675     4 EEVLKNVFPLLEGEDLASCMGVCKQWRDIARDDFYWKCQC 43
Cdd:pfam12937   6 DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
 1-40 1.35e-05

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 41.49  E-value: 1.35e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15241675   1 MFSEEVLKNVFPLLEGEDL-ASCMGVCKQWRDIARDDFY--WK 40
Cdd:cd22095   4 QLPEELLRNIFAFLPAEDLyQNISLVCRHWRDIVSDPLFipWK 46
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 5-47 1.75e-05

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 41.09  E-value: 1.75e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15241675   5 EVLKNVFPLLEGEDLASCMGVCKQWRDIARDDFYWKCQCAKKW 47
Cdd:cd22084   7 DPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKKYW 49
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
 1-40 3.05e-05

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 40.43  E-value: 3.05e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15241675   1 MFSEEVLKNVFPLLEGEDLASCMGVCKQWRDIARDDFYWK 40
Cdd:cd22149   3 RLSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWR 42
F-box_FBXO6-like cd22168
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ...
 4-73 5.60e-05

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438939 [Multi-domain]  Cd Length: 82  Bit Score: 40.73  E-value: 5.60e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15241675   4 EEVLKNVFPLLEGEDLA-SCMGVCKQWRDIARDDFYWKCQCaKKWPSVCKRHKPPTETYYKMYQTFSKRRL 73
Cdd:cd22168   9 EDVLLEILSLVPARDLIlSCRLVCSRWRDLVDLPTLWKRKC-QREGFILKDWDGPPKDWKIFYFLRLERNL 78
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
 2-40 8.86e-05

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 39.23  E-value: 8.86e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15241675   2 FSEEVLKNVFPLLEGEDLASCMGVCKQWRDIARDDFYWK 40
Cdd:cd22109   6 RRRDALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQ 44
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 1-34 1.46e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 38.19  E-value: 1.46e-04
                        10        20        30
                ....*....|....*....|....*....|....
gi 15241675   1 MFSEEVLKNVFPLLEGEDLASCMGVCKQWRDIAR 34
Cdd:cd09917   2 DLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 4-40 4.85e-04

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 36.82  E-value: 4.85e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 15241675   4 EEVLKNVFPLLEGEDLASCMGVCKQWRDIARDDFYWK 40
Cdd:cd22132   6 DSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWK 42
F-box_FBXL8 cd22121
F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also ...
 4-33 7.41e-04

F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also called F-box and leucine-rich repeat protein 8, or F-box protein FBL8, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438893  Cd Length: 35  Bit Score: 36.18  E-value: 7.41e-04
                        10        20        30
                ....*....|....*....|....*....|
gi 15241675   4 EEVLKNVFPLLEGEDLASCMGVCKQWRDIA 33
Cdd:cd22121   5 EEILVHIFRHLSLRDRYAAAQVCKHWREAA 34
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 2-43 9.87e-04

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 36.14  E-value: 9.87e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15241675   2 FSEEVLKNVFPLLEGEDLASCMGVCKQWRDIARDDFYWKCQC 43
Cdd:cd22151   3 LPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENAC 44
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 2-39 1.76e-03

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 35.39  E-value: 1.76e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15241675   2 FSEEVLKNVFPLLEGEDLASCMGVCKQWRDIARDDFYW 39
Cdd:cd22118   4 LPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
F-box_FBXO22 cd22097
F-box domain found in F-box only protein 22 (FBXO22) and similar proteins; FBXO22, also called ...
 5-34 3.07e-03

F-box domain found in F-box only protein 22 (FBXO22) and similar proteins; FBXO22, also called FBX22, or F-box protein FBX22p44, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. FBXO22 regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438869  Cd Length: 48  Bit Score: 34.65  E-value: 3.07e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 15241675   5 EVLKNVFPLLEGEDLASCMGVCKQWRDIAR 34
Cdd:cd22097   6 EIVERILSFLPAKALLRCARVCRLWRDCAR 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
4-40 3.58e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 34.33  E-value: 3.58e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 15241675      4 EEVLKNVFPLLEGEDLASCMGVCKQWRDIARDDFYWK 40
Cdd:smart00256   3 DEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 4-35 6.33e-03

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 33.85  E-value: 6.33e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 15241675   4 EEVLKNVFPLLEG-EDLASCMGVCKQWRDIARD 35
Cdd:cd22110   6 EEILEYILSYLSPyGDLKSAALVCKRWHRIIKG 38
F-box_AtSKIP31-like cd22166
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar ...
 5-40 6.82e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar proteins; AtSKIP31, also called F-box protein SKIP31, is a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438937  Cd Length: 46  Bit Score: 33.97  E-value: 6.82e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 15241675   5 EVLKNVFPLLEGEDLASCMGVCKQWRDIARDDFYWK 40
Cdd:cd22166   7 ELFRHILKFLSPEDLTSCATVCRFLRGAASDESLWR 42
F-box_FBXO17-like cd22169
F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and ...
 4-45 9.55e-03

F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and similar proteins; This subfamily includes FBXO17 and FBXO27. FBXO17 is also called FBX17, F-box only protein 26 (FBX26/FBXO26), or FBG4, while FBXO27 is also called FBX27, or F-box/G-domain protein 5. FBXO17 and FBXO27 are the substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. They can recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. FBXO17 also recognizes sulfated glycans but does not bind high-mannose glycoproteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438940  Cd Length: 48  Bit Score: 33.55  E-value: 9.55e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15241675   4 EEVLKNVFPLLEGEDLA-SCMGVCKQWRDIARDDFYWKCQCAK 45
Cdd:cd22169   6 EELLLLVLSHVPARTLVtRCRLVCRDWRDLVDGPTLWKLKCER 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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