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Conserved domains on  [gi|238481454|ref|NP_198822|]
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Disease resistance protein (NBS-LRR class) family [Arabidopsis thaliana]

Protein Classification

disease resistance family protein( domain architecture ID 1000118)

disease resistance family protein similar to Nicotiana glutinosa TMV resistance protein N; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein

Gene Ontology:  GO:0006952

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03210 super family cl33662
Resistant to P. syringae 6; Provisional
 1-968 0e+00

Resistant to P. syringae 6; Provisional


The actual alignment was detected with superfamily member PLN03210:

Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 1374.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454    1 MSSLLCLDSKEVRMVGIWGPSGIGKTTIARALFARLSRHFHCSVYIDRAFVSKSMASYSRANPDDYNMKLHLQETFLSTI 80
Cdd:PLN03210  196 MSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAFISKSMEIYSSANPDDYNMKLHLQRAFLSEI 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454   81 LGKQNIKIDHLGALGERLKHQKVLLFIDDLDQQVVLNALAGQIQWFGSGSRIIVVTNDKHLLISHGIENIYQVCLPSKEL 160
Cdd:PLN03210  276 LDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGSRIIVITKDKHFLRAHGIDHIYEVCLPSNEL 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  161 ALEMLCRYAFRQNTPPDGFKKLAVEVVRHAGILPLGLNVLGSYLRGRNKRYWMDMLPRLRKGLDGKIQKALRVGYDGLDN 240
Cdd:PLN03210  356 ALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRGRDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNN 435

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  241 KKDEAIFRHIACLFNFEKVNDIRLLLADSDLNFNIGLENLVDKSLVNVRSNIVEMHCLLQEMGREIVRAQSNEAGEREFL 320
Cdd:PLN03210  436 KKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHVREDIVEMHSLLQEMGKEIVRAQSNEPGEREFL 515

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  321 MDTEDICDVLDDNIGTKKMLGISLDVDEIDhELNVHEKAFQGMRNLRFLNIYTKALMSGQKIRLHLPENFDYLPPKLKLL 400
Cdd:PLN03210  516 VDAKDICDVLEDNTGTKKVLGITLDIDEID-ELHIHENAFKGMRNLLFLKFYTKKWDQKKEVRWHLPEGFDYLPPKLRLL 594

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  401 CWDKYPMRCLPSSFRPENLVKLKMQESELEKLWEGVGSLTCLKDMDLEKSKNLKEIPDLSMATNLKTLNLKYCSSLVKIS 480
Cdd:PLN03210  595 RWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELP 674

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  481 SSIQNLNKLTKLNMEGCTNLETLPAGINLKSLHRLDLRGCSRLRMFPDISNNISVLFLDKTSIEEFPSNLHLKKLFDLSM 560
Cdd:PLN03210  675 SSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLNLSGCSRLKSFPDISTNISWLDLDETAIEEFPSNLRLENLDELIL 754

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  561 QQMNSEKLWEGVQPLTCLMKMLSPPLAKnfntLYLSDIPSLVELPCGIQNLKKLMELSIRRCKNLESLPTGANFKYLDYL 640
Cdd:PLN03210  755 CEMKSEKLWERVQPLTPLMTMLSPSLTR----LFLSDIPSLVELPSSIQNLHKLEHLEIENCINLETLPTGINLESLESL 830

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  641 DLSGCSKLRSFPDISSTISCLCLNRTGIEEVPSWIENFVRLTYLTMLECNKLKYVSLNIFKLKHLDKADFSDCGTLTEVS 720
Cdd:PLN03210  831 DLSGCSRLRTFPDISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCNNLQRVSLNISKLKHLETVDFSDCGALTEAS 910

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  721 WCNKTISVAAATaDNIQPKLlvseaSSSLCvqksvVRFINCFKLDQEALLQQEPVFKSLILGGEEVPAYFNHRATGNSLV 800
Cdd:PLN03210  911 WNGSPSEVAMAT-DNIHSKL-----PSTVC-----INFINCFNLDQEALLQQQSIFKQLILSGEEVPSYFTHRTTGASLT 979

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  801 -IPLVPTSISLDFLGFRACALVDVKAMSMPG-RVDIQVSCRFRGSLKNHFDSADHSHSLVAFHKASHLLIFDCRFALNND 878
Cdd:PLN03210  980 nIPLLHISPCQPFFRFRACAVVDSESFFIISvSFDIQVCCRFIDRLGNHFDSPYQPHVFSVTKKGSHLVIFDCCFPLNED 1059

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  879 SNP---LNYAHMDITFHLTTDSVS-KINACGIRFSEGVSPQKHLNGpssivHVCEADESKLDNdrrhahETEHGEECGDS 954
Cdd:PLN03210 1060 NAPlaeLNYDHVDIQFRLTNKNSQlKLKGCGIRLSEDDSSLNNTLP-----NVEEADDDNPVN------GSEHWEDCEDS 1128

                         970
                  ....*....|....
gi 238481454  955 NVETVVSRKRIKIL 968
Cdd:PLN03210 1129 ALERESERTKDREM 1142
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 1-968 0e+00

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 1374.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454    1 MSSLLCLDSKEVRMVGIWGPSGIGKTTIARALFARLSRHFHCSVYIDRAFVSKSMASYSRANPDDYNMKLHLQETFLSTI 80
Cdd:PLN03210  196 MSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAFISKSMEIYSSANPDDYNMKLHLQRAFLSEI 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454   81 LGKQNIKIDHLGALGERLKHQKVLLFIDDLDQQVVLNALAGQIQWFGSGSRIIVVTNDKHLLISHGIENIYQVCLPSKEL 160
Cdd:PLN03210  276 LDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGSRIIVITKDKHFLRAHGIDHIYEVCLPSNEL 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  161 ALEMLCRYAFRQNTPPDGFKKLAVEVVRHAGILPLGLNVLGSYLRGRNKRYWMDMLPRLRKGLDGKIQKALRVGYDGLDN 240
Cdd:PLN03210  356 ALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRGRDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNN 435

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  241 KKDEAIFRHIACLFNFEKVNDIRLLLADSDLNFNIGLENLVDKSLVNVRSNIVEMHCLLQEMGREIVRAQSNEAGEREFL 320
Cdd:PLN03210  436 KKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHVREDIVEMHSLLQEMGKEIVRAQSNEPGEREFL 515

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  321 MDTEDICDVLDDNIGTKKMLGISLDVDEIDhELNVHEKAFQGMRNLRFLNIYTKALMSGQKIRLHLPENFDYLPPKLKLL 400
Cdd:PLN03210  516 VDAKDICDVLEDNTGTKKVLGITLDIDEID-ELHIHENAFKGMRNLLFLKFYTKKWDQKKEVRWHLPEGFDYLPPKLRLL 594

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  401 CWDKYPMRCLPSSFRPENLVKLKMQESELEKLWEGVGSLTCLKDMDLEKSKNLKEIPDLSMATNLKTLNLKYCSSLVKIS 480
Cdd:PLN03210  595 RWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELP 674

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  481 SSIQNLNKLTKLNMEGCTNLETLPAGINLKSLHRLDLRGCSRLRMFPDISNNISVLFLDKTSIEEFPSNLHLKKLFDLSM 560
Cdd:PLN03210  675 SSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLNLSGCSRLKSFPDISTNISWLDLDETAIEEFPSNLRLENLDELIL 754

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  561 QQMNSEKLWEGVQPLTCLMKMLSPPLAKnfntLYLSDIPSLVELPCGIQNLKKLMELSIRRCKNLESLPTGANFKYLDYL 640
Cdd:PLN03210  755 CEMKSEKLWERVQPLTPLMTMLSPSLTR----LFLSDIPSLVELPSSIQNLHKLEHLEIENCINLETLPTGINLESLESL 830

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  641 DLSGCSKLRSFPDISSTISCLCLNRTGIEEVPSWIENFVRLTYLTMLECNKLKYVSLNIFKLKHLDKADFSDCGTLTEVS 720
Cdd:PLN03210  831 DLSGCSRLRTFPDISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCNNLQRVSLNISKLKHLETVDFSDCGALTEAS 910

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  721 WCNKTISVAAATaDNIQPKLlvseaSSSLCvqksvVRFINCFKLDQEALLQQEPVFKSLILGGEEVPAYFNHRATGNSLV 800
Cdd:PLN03210  911 WNGSPSEVAMAT-DNIHSKL-----PSTVC-----INFINCFNLDQEALLQQQSIFKQLILSGEEVPSYFTHRTTGASLT 979

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  801 -IPLVPTSISLDFLGFRACALVDVKAMSMPG-RVDIQVSCRFRGSLKNHFDSADHSHSLVAFHKASHLLIFDCRFALNND 878
Cdd:PLN03210  980 nIPLLHISPCQPFFRFRACAVVDSESFFIISvSFDIQVCCRFIDRLGNHFDSPYQPHVFSVTKKGSHLVIFDCCFPLNED 1059

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  879 SNP---LNYAHMDITFHLTTDSVS-KINACGIRFSEGVSPQKHLNGpssivHVCEADESKLDNdrrhahETEHGEECGDS 954
Cdd:PLN03210 1060 NAPlaeLNYDHVDIQFRLTNKNSQlKLKGCGIRLSEDDSSLNNTLP-----NVEEADDDNPVN------GSEHWEDCEDS 1128

                         970
                  ....*....|....
gi 238481454  955 NVETVVSRKRIKIL 968
Cdd:PLN03210 1129 ALERESERTKDREM 1142
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
406-697 2.85e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 2.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 406 PMRCLPSSFRPENLVKLKMQESELEKLWEGVGSLTCLKDMDLEKSKNLKEIPDLSMATNLKTLNLKYCSSLVKISSSIQN 485
Cdd:COG4886   15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 486 LNKLTKLNMEGCTNLEtlpagiNLKSLHRLDLRGCSRLRMFPDISN--NISVLFLDKTSIEEFPSNL-HLKKL--FDLSM 560
Cdd:COG4886   95 LTNLTELDLSGNEELS------NLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEPLgNLTNLksLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 561 QQMNSeklwegvqpltclmkmLSPPLA--KNFNTLYLSDIPsLVELPCGIQNLKKLMELSIRRCKnLESLPTG-ANFKYL 637
Cdd:COG4886  169 NQLTD----------------LPEELGnlTNLKELDLSNNQ-ITDLPEPLGNLTNLEELDLSGNQ-LTDLPEPlANLTNL 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238481454 638 DYLDLSGCsKLRSFPDIS--STISCLCLNRTGIEEVPSwIENFVRLTYLTmLECNKLKYVSL 697
Cdd:COG4886  231 ETLDLSNN-QLTDLPELGnlTNLEELDLSNNQLTDLPP-LANLTNLKTLD-LSNNQLTDLKL 289
NB-ARC pfam00931
NB-ARC domain;
7-205 6.85e-11

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 63.55  E-value: 6.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454    7 LDSKEVRMVGIWGPSGIGKTTIARALFARLS---RHFHCSVYIdraFVSKSMASYsranpddynmklHLQETFLSTiLGK 83
Cdd:pfam00931  13 SEKDEPGIVGIHGMGGVGKTTLAAQIFNDFDeveGHFDSVAWV---VVSKTFTIS------------TLQQTILQN-LGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454   84 QNIKIDH------LGALGERLKHQKVLLFIDDLDQQVVLNALAGQIQWFGSGSRIIVVTNDKHLLISHG-IENIYQVCLP 156
Cdd:pfam00931  77 SEDDWDNkeegelARKIRRALLTKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEVAGRVGgPSDPHEVELL 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 238481454  157 SKELALEMLCRYAFRQNT-PPDGFKKLAVEVVRHAGILPLGLNVLGSYLR 205
Cdd:pfam00931 157 EPDEAWELFENKVFPKTLgECELLEDVAKEIVEKCRGLPLALKVLGGLLS 206
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 13-150 8.75e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 49.68  E-value: 8.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454    13 RMVGIWGPSGIGKTTIARALFARLSRHFHCSVYIDrafvsksmASYSRANPDDYNMKLHLQETFLSTILGKQNIKidhlg 92
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPGGGVIYID--------GEDILEEVLDQLLLIIVGGKKASGSGELRLRL----- 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 238481454    93 ALGERLKHQKVLLFIDDLD----------QQVVLNALAGQIQWFGSGSRIIVVTNDKHLLISHGIENI 150
Cdd:smart00382  70 ALALARKLKPDVLILDEITslldaeqealLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRR 137
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 17-143 1.66e-04

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 42.90  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  17 IWGPSGIGKTTIARALFARLSRHFHCSVYIdrafvsksmasysraNPDDYNMKLHLQETFLSTILGKQNikidhlgalGE 96
Cdd:cd00009   24 LYGPPGTGKTTLARAIANELFRPGAPFLYL---------------NASDLLEGLVVAELFGHFLVRLLF---------EL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 238481454  97 RLKHQKVLLFIDDLD------QQVVLNALAGQIQW--FGSGSRIIVVTNDKHLLI 143
Cdd:cd00009   80 AEKAKPGVLFIDEIDslsrgaQNALLRVLETLNDLriDRENVRVIGATNRPLLGD 134
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 1-968 0e+00

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 1374.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454    1 MSSLLCLDSKEVRMVGIWGPSGIGKTTIARALFARLSRHFHCSVYIDRAFVSKSMASYSRANPDDYNMKLHLQETFLSTI 80
Cdd:PLN03210  196 MSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAFISKSMEIYSSANPDDYNMKLHLQRAFLSEI 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454   81 LGKQNIKIDHLGALGERLKHQKVLLFIDDLDQQVVLNALAGQIQWFGSGSRIIVVTNDKHLLISHGIENIYQVCLPSKEL 160
Cdd:PLN03210  276 LDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGSRIIVITKDKHFLRAHGIDHIYEVCLPSNEL 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  161 ALEMLCRYAFRQNTPPDGFKKLAVEVVRHAGILPLGLNVLGSYLRGRNKRYWMDMLPRLRKGLDGKIQKALRVGYDGLDN 240
Cdd:PLN03210  356 ALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRGRDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNN 435

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  241 KKDEAIFRHIACLFNFEKVNDIRLLLADSDLNFNIGLENLVDKSLVNVRSNIVEMHCLLQEMGREIVRAQSNEAGEREFL 320
Cdd:PLN03210  436 KKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHVREDIVEMHSLLQEMGKEIVRAQSNEPGEREFL 515

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  321 MDTEDICDVLDDNIGTKKMLGISLDVDEIDhELNVHEKAFQGMRNLRFLNIYTKALMSGQKIRLHLPENFDYLPPKLKLL 400
Cdd:PLN03210  516 VDAKDICDVLEDNTGTKKVLGITLDIDEID-ELHIHENAFKGMRNLLFLKFYTKKWDQKKEVRWHLPEGFDYLPPKLRLL 594

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  401 CWDKYPMRCLPSSFRPENLVKLKMQESELEKLWEGVGSLTCLKDMDLEKSKNLKEIPDLSMATNLKTLNLKYCSSLVKIS 480
Cdd:PLN03210  595 RWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELP 674

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  481 SSIQNLNKLTKLNMEGCTNLETLPAGINLKSLHRLDLRGCSRLRMFPDISNNISVLFLDKTSIEEFPSNLHLKKLFDLSM 560
Cdd:PLN03210  675 SSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLNLSGCSRLKSFPDISTNISWLDLDETAIEEFPSNLRLENLDELIL 754

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  561 QQMNSEKLWEGVQPLTCLMKMLSPPLAKnfntLYLSDIPSLVELPCGIQNLKKLMELSIRRCKNLESLPTGANFKYLDYL 640
Cdd:PLN03210  755 CEMKSEKLWERVQPLTPLMTMLSPSLTR----LFLSDIPSLVELPSSIQNLHKLEHLEIENCINLETLPTGINLESLESL 830

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  641 DLSGCSKLRSFPDISSTISCLCLNRTGIEEVPSWIENFVRLTYLTMLECNKLKYVSLNIFKLKHLDKADFSDCGTLTEVS 720
Cdd:PLN03210  831 DLSGCSRLRTFPDISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCNNLQRVSLNISKLKHLETVDFSDCGALTEAS 910

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  721 WCNKTISVAAATaDNIQPKLlvseaSSSLCvqksvVRFINCFKLDQEALLQQEPVFKSLILGGEEVPAYFNHRATGNSLV 800
Cdd:PLN03210  911 WNGSPSEVAMAT-DNIHSKL-----PSTVC-----INFINCFNLDQEALLQQQSIFKQLILSGEEVPSYFTHRTTGASLT 979

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  801 -IPLVPTSISLDFLGFRACALVDVKAMSMPG-RVDIQVSCRFRGSLKNHFDSADHSHSLVAFHKASHLLIFDCRFALNND 878
Cdd:PLN03210  980 nIPLLHISPCQPFFRFRACAVVDSESFFIISvSFDIQVCCRFIDRLGNHFDSPYQPHVFSVTKKGSHLVIFDCCFPLNED 1059

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  879 SNP---LNYAHMDITFHLTTDSVS-KINACGIRFSEGVSPQKHLNGpssivHVCEADESKLDNdrrhahETEHGEECGDS 954
Cdd:PLN03210 1060 NAPlaeLNYDHVDIQFRLTNKNSQlKLKGCGIRLSEDDSSLNNTLP-----NVEEADDDNPVN------GSEHWEDCEDS 1128

                         970
                  ....*....|....
gi 238481454  955 NVETVVSRKRIKIL 968
Cdd:PLN03210 1129 ALERESERTKDREM 1142
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
406-697 2.85e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 2.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 406 PMRCLPSSFRPENLVKLKMQESELEKLWEGVGSLTCLKDMDLEKSKNLKEIPDLSMATNLKTLNLKYCSSLVKISSSIQN 485
Cdd:COG4886   15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 486 LNKLTKLNMEGCTNLEtlpagiNLKSLHRLDLRGCSRLRMFPDISN--NISVLFLDKTSIEEFPSNL-HLKKL--FDLSM 560
Cdd:COG4886   95 LTNLTELDLSGNEELS------NLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEPLgNLTNLksLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 561 QQMNSeklwegvqpltclmkmLSPPLA--KNFNTLYLSDIPsLVELPCGIQNLKKLMELSIRRCKnLESLPTG-ANFKYL 637
Cdd:COG4886  169 NQLTD----------------LPEELGnlTNLKELDLSNNQ-ITDLPEPLGNLTNLEELDLSGNQ-LTDLPEPlANLTNL 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238481454 638 DYLDLSGCsKLRSFPDIS--STISCLCLNRTGIEEVPSwIENFVRLTYLTmLECNKLKYVSL 697
Cdd:COG4886  231 ETLDLSNN-QLTDLPELGnlTNLEELDLSNNQLTDLPP-LANLTNLKTLD-LSNNQLTDLKL 289
NB-ARC pfam00931
NB-ARC domain;
7-205 6.85e-11

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 63.55  E-value: 6.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454    7 LDSKEVRMVGIWGPSGIGKTTIARALFARLS---RHFHCSVYIdraFVSKSMASYsranpddynmklHLQETFLSTiLGK 83
Cdd:pfam00931  13 SEKDEPGIVGIHGMGGVGKTTLAAQIFNDFDeveGHFDSVAWV---VVSKTFTIS------------TLQQTILQN-LGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454   84 QNIKIDH------LGALGERLKHQKVLLFIDDLDQQVVLNALAGQIQWFGSGSRIIVVTNDKHLLISHG-IENIYQVCLP 156
Cdd:pfam00931  77 SEDDWDNkeegelARKIRRALLTKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEVAGRVGgPSDPHEVELL 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 238481454  157 SKELALEMLCRYAFRQNT-PPDGFKKLAVEVVRHAGILPLGLNVLGSYLR 205
Cdd:pfam00931 157 EPDEAWELFENKVFPKTLgECELLEDVAKEIVEKCRGLPLALKVLGGLLS 206
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
588-705 2.01e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 2.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 588 KNFNTLYLSDiPSLVELPCGIQNLKKLMELSIRRCkNLESLPTG-ANFKYLDYLDLSGCsKLRSFPDISSTIS---CLCL 663
Cdd:COG4886  113 TNLESLDLSG-NQLTDLPEELANLTNLKELDLSNN-QLTDLPEPlGNLTNLKSLDLSNN-QLTDLPEELGNLTnlkELDL 189

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 238481454 664 NRTGIEEVPSWIENFVRLTYLtMLECNKLKYVSLNIFKLKHL 705
Cdd:COG4886  190 SNNQITDLPEPLGNLTNLEEL-DLSGNQLTDLPEPLANLTNL 230
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 13-150 8.75e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 49.68  E-value: 8.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454    13 RMVGIWGPSGIGKTTIARALFARLSRHFHCSVYIDrafvsksmASYSRANPDDYNMKLHLQETFLSTILGKQNIKidhlg 92
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPGGGVIYID--------GEDILEEVLDQLLLIIVGGKKASGSGELRLRL----- 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 238481454    93 ALGERLKHQKVLLFIDDLD----------QQVVLNALAGQIQWFGSGSRIIVVTNDKHLLISHGIENI 150
Cdd:smart00382  70 ALALARKLKPDVLILDEITslldaeqealLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRR 137
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
497-713 5.96e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 5.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 497 CTNLETLPAGINLKSLHRLDLRGCSRLRMFPDISNNISVLFLDKTSIEEFPSNLHLKKLFDLSMQQMNSEKLWEGVQPLT 576
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 577 CLMKMLSPPLAKNFNTLYLSDIPSLVElpcgIQNLKKLMELSIRRCKnLESLPTG-ANFKYLDYLDLSGCsKLRSFPD-I 654
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNEE----LSNLTNLESLDLSGNQ-LTDLPEElANLTNLKELDLSNN-QLTDLPEpL 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238481454 655 SS--TISCLCLNRTGIEEVPSWIENFVRLTYLTmLECNKLKYVSLNIFKLKHLDKADFSDC 713
Cdd:COG4886  156 GNltNLKSLDLSNNQLTDLPEELGNLTNLKELD-LSNNQITDLPEPLGNLTNLEELDLSGN 215
COG3903 COG3903
Predicted ATPase [General function prediction only];
11-318 6.20e-06

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 50.40  E-value: 6.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  11 EVRMVGIWGPSGIGKTTIARALFARLSRHFHCSVYidraFVskSMASYSRanPDDynmklhLQETFLSTiLG-KQNIKID 89
Cdd:COG3903  175 AARLVTLTGPGGVGKTRLALEVAHRLADRFPDGVW----FV--DLAGVTD--PAL------VLAAVARA-LGvRDAPGRD 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  90 HLGALGERLKHQKVLLFIDDLDQqvVLNALAGQI-QWFGSGSRI-IVVTNDKHLLISHgiENIYQV---CLPSKEL---- 160
Cdd:COG3903  240 PAARLRAALADRRLLLVLDNCEH--VVDAAAALVrPLLPAAPGLrVLATSREPLGLPG--ERVLPLpplAVPPPGAeala 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 161 --ALEMLCRYAFRQN---TPPDGFKKLAVEVVRHAGILPLGLNVLGSYLRGRNKRywmDMLPRLRKGLDgkiqkALRVG- 234
Cdd:COG3903  316 seAVALFVERAGAARpgfALDAAEAAAVAEICRRLDGLPLAIELAAARLRTLSLA---ELAARLDDRLR-----LLTGGr 387

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 235 -----------------YDGLDnkKDE-AIFRHIACL---FNFEkvnDIRLLLADS------DLnfnigLENLVDKSLVN 287
Cdd:COG3903  388 rdapprhrtlraaldwsYDLLS--PAErRLLRRLSVFpggFTLE---AAEAVCGGDgpadvlDL-----LAALVDKSLLE 457

                        330       340       350
                 ....*....|....*....|....*....|.
gi 238481454 288 VRSNIVEMHCLLQEMGREIVRAQSNEAGERE 318
Cdd:COG3903  458 VEGGGGGPRYRLLETVREYAAERLAEAGERA 488
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 17-144 2.58e-05

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 44.89  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454   17 IWGPSGIGKTTIARALFARLSRHFhcsVYIDrafVSKSMASYSRANPDDynmklhLQETFlstilgkQNIKidhlgalge 96
Cdd:pfam00004   3 LYGPPGTGKTTLAKAVAKELGAPF---IEIS---GSELVSKYVGESEKR------LRELF-------EAAK--------- 54

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 238481454   97 rlKHQKVLLFIDDLDQ-------------QVVLNALAGQIQWFGS-GSRIIVV--TNDKHLLIS 144
Cdd:pfam00004  55 --KLAPCVIFIDEIDAlagsrgsggdsesRRVVNQLLTELDGFTSsNSKVIVIaaTNRPDKLDP 116
LRR_3 pfam07725
Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the ...
 418-436 3.68e-05

Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the pfam00560 model.


Pssm-ID: 429621 [Multi-domain]  Cd Length: 20  Bit Score: 41.17  E-value: 3.68e-05
                          10
                  ....*....|....*....
gi 238481454  418 NLVKLKMQESELEKLWEGV 436
Cdd:pfam07725   1 NLVELNMPYSKLEKLWEGV 19
C-JID pfam20160
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 781-908 7.96e-05

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


Pssm-ID: 466313  Cd Length: 108  Bit Score: 42.82  E-value: 7.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  781 LGGEEVPAYFNHRATGNSLVIPLVPTSISLDFLGFRACALVDvkamsmpgrvdiqvscrfrgslknhFDSADHSHsLVAF 860
Cdd:pfam20160   1 LPGSQIPEWFNHQSTGSSISIKLPENWYNDNFLGFAVCAVGS-------------------------LIPSLHNF-LGYI 54

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 238481454  861 HKASHLLIFDCRFALNNDSNPLNYAHMDITFHLTTDSVsKINACGIRF 908
Cdd:pfam20160  55 HFFLIPLVSLWDTSKANGKTPNDYGRIEASFEFPSDLH-EIKQCGVRL 101
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 17-143 1.66e-04

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 42.90  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  17 IWGPSGIGKTTIARALFARLSRHFHCSVYIdrafvsksmasysraNPDDYNMKLHLQETFLSTILGKQNikidhlgalGE 96
Cdd:cd00009   24 LYGPPGTGKTTLARAIANELFRPGAPFLYL---------------NASDLLEGLVVAELFGHFLVRLLF---------EL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 238481454  97 RLKHQKVLLFIDDLD------QQVVLNALAGQIQW--FGSGSRIIVVTNDKHLLI 143
Cdd:cd00009   80 AEKAKPGVLFIDEIDslsrgaQNALLRVLETLNDLriDRENVRVIGATNRPLLGD 134
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-571 2.63e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 358 KAFQGMRNLRFLNIytkalmSGQKIRlHLPENFDYLPpKLKLLCWDKYPMRCLPSSF-RPENLVKLKMQESELEKLWEGV 436
Cdd:COG4886  153 EPLGNLTNLKSLDL------SNNQLT-DLPEELGNLT-NLKELDLSNNQITDLPEPLgNLTNLEELDLSGNQLTDLPEPL 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 437 GSLTCLKDMDLEKSKnLKEIPDLSMATNLKTLNLKYCsslvKIS--SSIQNLNKLTKLNMEGC----TNLETLPAGINLK 510
Cdd:COG4886  225 ANLTNLETLDLSNNQ-LTDLPELGNLTNLEELDLSNN----QLTdlPPLANLTNLKTLDLSNNqltdLKLKELELLLGLN 299

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238481454 511 SLHRLDLRGCSRLRMFPDISNNISVLFLDKTSIEEFPSNLHLKKLFDLSMQQMNSEKLWEG 571
Cdd:COG4886  300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLS 360
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 9-47 3.69e-04

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 42.91  E-value: 3.69e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 238481454   9 SKEVRMVGIWGPSGIGKTTIARALFARLSRHFHCSVYID 47
Cdd:COG0572    4 SGKPRIIGIAGPSGSGKTTFARRLAEQLGADKVVVISLD 42
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
7-134 4.11e-04

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 44.41  E-value: 4.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454   7 LDSKEVRMVgIWGPSGIGKTTIARALFARLSRHFHCS-----VYIdrafvskSMASYSRANPddynmklhLQETFLSTIL 81
Cdd:COG5635  176 LEAKKKRLL-ILGEPGSGKTTLLRYLALELAERYLDAedpipILI-------ELRDLAEEAS--------LEDLLAEALE 239

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  82 GKQNIKIDHLGALgerLKHQKVLLFIDDLD-------QQVVLNALAGQIQWFgSGSRIIV 134
Cdd:COG5635  240 KRGGEPEDALERL---LRNGRLLLLLDGLDevpdeadRDEVLNQLRRFLERY-PKARVII 295
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 18-41 1.00e-03

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 42.74  E-value: 1.00e-03
                         10        20
                 ....*....|....*....|....
gi 238481454  18 WGPSGIGKTTIARALFARLSRHFH 41
Cdd:COG2256   55 WGPPGTGKTTLARLIANATDAEFV 78
LRR_3 pfam07725
Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the ...
 554-573 1.42e-03

Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the pfam00560 model.


Pssm-ID: 429621 [Multi-domain]  Cd Length: 20  Bit Score: 36.93  E-value: 1.42e-03
                          10        20
                  ....*....|....*....|
gi 238481454  554 KLFDLSMQQMNSEKLWEGVQ 573
Cdd:pfam07725   1 NLVELNMPYSKLEKLWEGVK 20
PRK05541 PRK05541
adenylylsulfate kinase; Provisional
 17-47 1.75e-03

adenylylsulfate kinase; Provisional


Pssm-ID: 235498  Cd Length: 176  Bit Score: 40.42  E-value: 1.75e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 238481454  17 IW--GPSGIGKTTIARALFARLSRHFHCSVYID 47
Cdd:PRK05541  10 IWitGLAGSGKTTIAKALYERLKLKYSNVIYLD 42
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 18-108 1.98e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 41.61  E-value: 1.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  18 WGPSGIGKTTIARALFARLSRHFhcsvyidrafvsksmasysranpddynmklhlqETFLSTILGKQNIK--IDHlgALG 95
Cdd:PRK13342  42 WGPPGTGKTTLARIIAGATDAPF---------------------------------EALSAVTSGVKDLRevIEE--ARQ 86

                         90
                 ....*....|...
gi 238481454  96 ERLKHQKVLLFID 108
Cdd:PRK13342  87 RRSAGRRTILFID 99
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 9-112 2.34e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 39.79  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454    9 SKEVRMVGIWGPSGIGKTTIARALFARLSRH------FHCSVYIDRAFVSKSMASYSRANPDDYNMKLHLQETFLSTILG 82
Cdd:pfam13191  21 SGRPPSVLLTGEAGTGKTTLLRELLRALERDggyflrGKCDENLPYSPLLEALTREGLLRQLLDELESSLLEAWRAALLE 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 238481454   83 KQNIKIDHLGALGERL-------------KHQKVLLFIDDLDQ 112
Cdd:pfam13191 101 ALAPVPELPGDLAERLldlllrlldllarGERPLVLVLDDLQW 143
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 19-109 4.83e-03

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 39.77  E-value: 4.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454  19 GPSGIGKTTIARALFARLSRHFHcSVYIdrafvsksmaSYSRANPDDynmklhlqetFLSTI---LGKQNIKIDH---LG 92
Cdd:COG3267   50 GEVGTGKTTLLRRLLERLPDDVK-VAYI----------PNPQLSPAE----------LLRAIadeLGLEPKGASKadlLR 108

                         90       100
                 ....*....|....*....|..
gi 238481454  93 ALGERLKHQ-----KVLLFIDD 109
Cdd:COG3267  109 QLQEFLLELaaagrRVVLIIDE 130
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
17-47 5.06e-03

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 40.22  E-value: 5.06e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 238481454  17 IWGPSGIGKTTIARALFARLSRHFHCS------VYID 47
Cdd:COG1474   56 IYGPTGTGKTAVAKYVLEELEEEAEERgvdvrvVYVN 92
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 463-651 7.61e-03

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 39.23  E-value: 7.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 463 TNLKTLNLKYCSSLVKISSSIQNLNKLTKLNMEGCTNL--ETLPA-GINLKSLHRLDLRGCSRLrmfpdisNNISVLFLd 539
Cdd:cd09293   28 SGLEWLELYMCPISDPPLDQLSNCNKLKKLILPGSKLIddEGLIAlAQSCPNLQVLDLRACENI-------TDSGIVAL- 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238481454 540 ktsieefpsNLHLKKL--FDLSMQQMNSEKLWEGVQPLTCLMKMLSpplaknfnTLYLS--DIP--SLVELpcGIQNLKK 613
Cdd:cd09293  100 ---------ATNCPKLqtINLGRHRNGHLITDVSLSALGKNCTFLQ--------TVGFAgcDVTdkGVWEL--ASGCSKS 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 238481454 614 LMELSIRRCKNL-----ESLPTGANFKYLDYLDLSGCSKLRSF 651
Cdd:cd09293  161 LERLSLNNCRNLtdqsiPAILASNYFPNLSVLEFRGCPLITDF 203
GMPK cd00071
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), ...
 19-44 9.66e-03

Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine diphosphate (GDP). It plays an essential role in the biosynthesis of guanosine triphosphate (GTP). This enzyme is also important for the activation of some antiviral and anticancer agents, such as acyclovir, ganciclovir, carbovir, and thiopurines.


Pssm-ID: 238026  Cd Length: 137  Bit Score: 37.51  E-value: 9.66e-03
                         10        20
                 ....*....|....*....|....*.
gi 238481454  19 GPSGIGKTTIARALFARLSRHFHCSV 44
Cdd:cd00071    6 GPSGVGKSTLLKRLLEEFDPNFGFSV 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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