|
Name |
Accession |
Description |
Interval |
E-value |
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
39-548 |
0e+00 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 636.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 39 YAVILGFGAFFAVFTSFLVWLEKRYVGARHTSEWFNTAGRNVKTGLIASVIVSQWTWAATILQSSNVAWQYGVSGPFWYA 118
Cdd:cd11476 1 YGVVIGLGALFALLMVFITRLLKRYRGKNQSSEEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSATVAYQYGVSGPFWYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 119 SGATIQVLLFGVMAIEIKRKAPNAHTVCEIVKARWGTATHIVFLVFCLATNVVVTAMLLLGGSAVVNALTGVNLYAASFL 198
Cdd:cd11476 81 SGATLQILLFAPLAIRIKRLAPNAHTLLEIVRARYGTAAHLVFLVFALFTNVIVLAMLLLGGSAVVNALTGMPIVAASFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 199 IPLGVVVYTLAGGLKATFLASYVHSVIVHVALVVFVFLVYTSSkELGSPSVVYDRLKDMVAKSrscteplshhgqacgPV 278
Cdd:cd11476 161 IPLGVLLYTLFGGLRATFLTDYIHTVIILIILLVFAFAVYTSS-DIGSPSKVYDLLQEAAPDL---------------PV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 279 DGNfRGSYLTMLSSGGAVFGLINIVGNFGTVFVDNGYWVSAIAARPSSTHKGYLLGGLVWFAVPFSLATSLGLGALALDL 358
Cdd:cd11476 225 EGN-QGSYLTFKSKAGLIFGIINIVGNFGTVFLDQGYWQRAIAARPSAAVKGYFLGGLAWFAIPFLLATTLGLAALALGL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 359 PISKDEADRGLVPPATAIALMGKSGSLLLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQILKISRCAVLG 438
Cdd:cd11476 304 NPTFEEVSAGLVLPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYRTYINPNATGKQLLRVSRIAVIG 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 439 FGCFMGILAVVLNKAGVSLGWMYLAMGVLIGSAVIPIAFMLLWSKANAFGAILGATSGCVFGIITWLTTAKTQYGRVDLD 518
Cdd:cd11476 384 FGLFMGGLAVGLNYIGISLGWLLLFMGILIGSAVFPVALGLYWRRQTGTAAVVSPIAGLVAGLAVWLVTAKSYYGEVNVD 463
|
490 500 510
....*....|....*....|....*....|
gi 334188207 519 STGKNGPMLAGNLVAILTGGLIHAVCSLVR 548
Cdd:cd11476 464 TTGGNYPMLAGNLVALFSPAIVSVLLSLIF 493
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
76-492 |
4.20e-44 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 163.63 E-value: 4.20e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 76 AGRNVKTGLIASVIVSQWTWAATILQSSNVAWQYGVSGpFWYASGATIQVLLFGVMAIEIKRKApNAHTVCEIVKARWG- 154
Cdd:TIGR00813 1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAI-GFYELGALVLLIILGWLFVPIFINN-GAYTMPEYLEKRFGk 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 155 TATHIVFLVFCLATNVVVTAMLLLGGSAVVNALTGVNLYAASFLIPLGVVVYTLAGGLKATFLASYVHSVIVhvaLVVFV 234
Cdd:TIGR00813 79 RILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIM---ILGTF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 235 FLVYTSSKELGSPSVVYDRLKDmvaksrscteplshHGQACGPVDGNFRGSYLTMLSSGGAVFGLINIVGNFGTVFVDNG 314
Cdd:TIGR00813 156 ILPVFAFSEVGGLGTFVEKASQ--------------AAPTNPSPDDLYDFFRDPSTSDLPWGAGVFGLPHVALWYWTNQV 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 315 YWVSAIAARPSSTHKGYLLGGLVWFAVPFSLAT-----SLGLGALALDLPISKDEADRGLVPPATAIALMGKSGSLLLLT 389
Cdd:TIGR00813 222 IVQRCLAAKSAKHAKKGCLISGVLKLLPMFGAVlpgliARALYTDIDPALAGAVNQNSDQAYPLLVQELMPPGLAGLFLA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 390 MLFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQ-ILKISRCAVLGFGCFMGilAVVLNKAGVSLGWMYLAMGVLI 468
Cdd:TIGR00813 302 AILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASGEKkIVMRGRIAVLVAAVIAG--FVAAAQGGQVLQYVQEAFGGLG 379
|
410 420
....*....|....*....|....
gi 334188207 469 GSAVIPIAFMLLWSKANAFGAILG 492
Cdd:TIGR00813 380 APFLPVFLLGIFWKRMNAKGALAG 403
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
42-543 |
5.02e-38 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 147.66 E-value: 5.02e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 42 ILGFGAFFAVFTSFLVWLEKRyvgARHTSEWFnTAGRNVKTGLIASVIVSQWTWAATILQSSNVAWQYGVSGpFWYASGA 121
Cdd:COG0591 6 LIIIILYLLLLLGIGLYASRR---TKSLEDYF-LAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSA-LWYALGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 122 TIQVLLFGVMAIEIKRKApNAHTVCEIVKARWGTATHIVFLVFCLATNVVVTAMLLLGGSAVVNALTGVNLYAASFLIPL 201
Cdd:COG0591 81 ALGALLLALFFAPRLRRL-GALTIPEFLEKRFGRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILIGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 202 GVVVYTLAGGLKATFLASYVHSVIVhvaLVVFVFLVYTSSKELGSPSVVYDRLKDmvaksrscteplSHHGQACGPVDGN 281
Cdd:COG0591 160 IVLLYTVLGGLRAVAWTDVLQGILM---LVGLILLLIVALSALGGFGELFAALPA------------PGLLSLFPGLGFT 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 282 FRGSYLTMLssggavfglinIVGNFGtVFVDNGYWVSAIAAR-PSSTHKGYLLGGLVWFAVPFsLATSLGLGALALDLPI 360
Cdd:COG0591 225 GWLAFLGLF-----------LAIGLG-YFGQPHIVQRFLAAKsEKEARKAALIGGLLYLLFYL-LAALIGLLARALFPDL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 361 SKDEADrgLVPPATAIALMGKSGSLLLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQILKISRCAVLGFG 440
Cdd:COG0591 292 PLADPD--LALPLLILELLPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVG 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 441 CFMGILAvvLNKAGVSLGWMYLAMGVLIGSAVIPIAFMLLWSKANAFGAILGATSGCVFGIITWLTTAKtqygrvdLDST 520
Cdd:COG0591 370 LLALLLA--LLFPSSILDLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLGGP-------LGPF 440
|
490 500
....*....|....*....|...
gi 334188207 521 GKNGPMLAGNLVAILTGGLIHAV 543
Cdd:COG0591 441 GWLYPILPGLLVSLLVFVVVSLL 463
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
73-496 |
8.63e-11 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 64.67 E-value: 8.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 73 FNTAGRNVKTGLIASVIVSQWTWAATILQSSNVAWQYGVSGpFWYASGATIQVLLFGVMAIEIKRKApNAHTVCEIVKAR 152
Cdd:pfam00474 1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAG-GLYAIGALVGVWLLLWLFAPRLRNL-GAYTMPDYLRKR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 153 WGTATHIVFLVFCLATNVVVTAML--LLGGSAVVNALTGVNLYAASFLIPLGVVVYTLAGGLKATFLASYVHSVIVHVAL 230
Cdd:pfam00474 79 FGGKRILVYLSALSLLLYFFTYMSvqIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 231 VVFVFLVYtssKELGSPSVVYDRLKDMVAKSRSCTEPLSHHGQAcgpvdgnfrgSYLTMLSSGGA----VFGLINIVGNF 306
Cdd:pfam00474 159 IILMIIVF---HEVGGYSSAVEKYMTADPNGVDLYTPDGLHILR----------DPLTGLSLWPGlvlgTTGLPHILQRC 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 307 gtvfvdngywvsaIAARPSST-HKGYLLgGLVWFAVPFSLATSLGLGALALDLPISK----DEADRGLVPPATAIALMGK 381
Cdd:pfam00474 226 -------------LAAKDAKCiRCGVLI-LTPMFIIVMPGMISRGLFAIALAGANPRacgtVVGCSNIAYPTLAVKLGPP 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 382 SGSLLLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYINP-RATGRQILKISRCAVLGFGCFMGILAVVLNKAGVsLGWM 460
Cdd:pfam00474 292 GLAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKaSATEKELVGRSRIIVLVVISLAILLAVQPAQMGI-AFLV 370
|
410 420 430
....*....|....*....|....*....|....*..
gi 334188207 461 YLAMGVLiGSAVIP-IAFMLLWSKANAFGAILGATSG 496
Cdd:pfam00474 371 QLAFAGL-GSAFLPvILLAIFWKRVNEQGALWGMIIG 406
|
|
| PRK10484 |
PRK10484 |
putative transporter; Provisional |
391-503 |
1.53e-04 |
|
putative transporter; Provisional
Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 44.87 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 391 LFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQILKISRCAVLGFGCFMGILAVVLNKAGVSLgwmYLAMGVLIGS 470
Cdd:PRK10484 336 LFGAILSTFNGFLNSASTLFSLDIYKPIINPNASEKQLVKVGKKFGFVLAIISMIVAPLIANAPQGL---YSYLQQLNGI 412
|
90 100 110
....*....|....*....|....*....|....*..
gi 334188207 471 AVIPIAFM----LLWSKANAFGAILGATSGCVFGIIT 503
Cdd:PRK10484 413 YNVPILAIiivgFFTKRVPALAAKVALGFGIILYIII 449
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
39-548 |
0e+00 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 636.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 39 YAVILGFGAFFAVFTSFLVWLEKRYVGARHTSEWFNTAGRNVKTGLIASVIVSQWTWAATILQSSNVAWQYGVSGPFWYA 118
Cdd:cd11476 1 YGVVIGLGALFALLMVFITRLLKRYRGKNQSSEEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSATVAYQYGVSGPFWYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 119 SGATIQVLLFGVMAIEIKRKAPNAHTVCEIVKARWGTATHIVFLVFCLATNVVVTAMLLLGGSAVVNALTGVNLYAASFL 198
Cdd:cd11476 81 SGATLQILLFAPLAIRIKRLAPNAHTLLEIVRARYGTAAHLVFLVFALFTNVIVLAMLLLGGSAVVNALTGMPIVAASFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 199 IPLGVVVYTLAGGLKATFLASYVHSVIVHVALVVFVFLVYTSSkELGSPSVVYDRLKDMVAKSrscteplshhgqacgPV 278
Cdd:cd11476 161 IPLGVLLYTLFGGLRATFLTDYIHTVIILIILLVFAFAVYTSS-DIGSPSKVYDLLQEAAPDL---------------PV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 279 DGNfRGSYLTMLSSGGAVFGLINIVGNFGTVFVDNGYWVSAIAARPSSTHKGYLLGGLVWFAVPFSLATSLGLGALALDL 358
Cdd:cd11476 225 EGN-QGSYLTFKSKAGLIFGIINIVGNFGTVFLDQGYWQRAIAARPSAAVKGYFLGGLAWFAIPFLLATTLGLAALALGL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 359 PISKDEADRGLVPPATAIALMGKSGSLLLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQILKISRCAVLG 438
Cdd:cd11476 304 NPTFEEVSAGLVLPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYRTYINPNATGKQLLRVSRIAVIG 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 439 FGCFMGILAVVLNKAGVSLGWMYLAMGVLIGSAVIPIAFMLLWSKANAFGAILGATSGCVFGIITWLTTAKTQYGRVDLD 518
Cdd:cd11476 384 FGLFMGGLAVGLNYIGISLGWLLLFMGILIGSAVFPVALGLYWRRQTGTAAVVSPIAGLVAGLAVWLVTAKSYYGEVNVD 463
|
490 500 510
....*....|....*....|....*....|
gi 334188207 519 STGKNGPMLAGNLVAILTGGLIHAVCSLVR 548
Cdd:cd11476 464 TTGGNYPMLAGNLVALFSPAIVSVLLSLIF 493
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
76-492 |
4.20e-44 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 163.63 E-value: 4.20e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 76 AGRNVKTGLIASVIVSQWTWAATILQSSNVAWQYGVSGpFWYASGATIQVLLFGVMAIEIKRKApNAHTVCEIVKARWG- 154
Cdd:TIGR00813 1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAI-GFYELGALVLLIILGWLFVPIFINN-GAYTMPEYLEKRFGk 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 155 TATHIVFLVFCLATNVVVTAMLLLGGSAVVNALTGVNLYAASFLIPLGVVVYTLAGGLKATFLASYVHSVIVhvaLVVFV 234
Cdd:TIGR00813 79 RILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIM---ILGTF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 235 FLVYTSSKELGSPSVVYDRLKDmvaksrscteplshHGQACGPVDGNFRGSYLTMLSSGGAVFGLINIVGNFGTVFVDNG 314
Cdd:TIGR00813 156 ILPVFAFSEVGGLGTFVEKASQ--------------AAPTNPSPDDLYDFFRDPSTSDLPWGAGVFGLPHVALWYWTNQV 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 315 YWVSAIAARPSSTHKGYLLGGLVWFAVPFSLAT-----SLGLGALALDLPISKDEADRGLVPPATAIALMGKSGSLLLLT 389
Cdd:TIGR00813 222 IVQRCLAAKSAKHAKKGCLISGVLKLLPMFGAVlpgliARALYTDIDPALAGAVNQNSDQAYPLLVQELMPPGLAGLFLA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 390 MLFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQ-ILKISRCAVLGFGCFMGilAVVLNKAGVSLGWMYLAMGVLI 468
Cdd:TIGR00813 302 AILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASGEKkIVMRGRIAVLVAAVIAG--FVAAAQGGQVLQYVQEAFGGLG 379
|
410 420
....*....|....*....|....
gi 334188207 469 GSAVIPIAFMLLWSKANAFGAILG 492
Cdd:TIGR00813 380 APFLPVFLLGIFWKRMNAKGALAG 403
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
42-543 |
5.02e-38 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 147.66 E-value: 5.02e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 42 ILGFGAFFAVFTSFLVWLEKRyvgARHTSEWFnTAGRNVKTGLIASVIVSQWTWAATILQSSNVAWQYGVSGpFWYASGA 121
Cdd:COG0591 6 LIIIILYLLLLLGIGLYASRR---TKSLEDYF-LAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSA-LWYALGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 122 TIQVLLFGVMAIEIKRKApNAHTVCEIVKARWGTATHIVFLVFCLATNVVVTAMLLLGGSAVVNALTGVNLYAASFLIPL 201
Cdd:COG0591 81 ALGALLLALFFAPRLRRL-GALTIPEFLEKRFGRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILIGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 202 GVVVYTLAGGLKATFLASYVHSVIVhvaLVVFVFLVYTSSKELGSPSVVYDRLKDmvaksrscteplSHHGQACGPVDGN 281
Cdd:COG0591 160 IVLLYTVLGGLRAVAWTDVLQGILM---LVGLILLLIVALSALGGFGELFAALPA------------PGLLSLFPGLGFT 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 282 FRGSYLTMLssggavfglinIVGNFGtVFVDNGYWVSAIAAR-PSSTHKGYLLGGLVWFAVPFsLATSLGLGALALDLPI 360
Cdd:COG0591 225 GWLAFLGLF-----------LAIGLG-YFGQPHIVQRFLAAKsEKEARKAALIGGLLYLLFYL-LAALIGLLARALFPDL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 361 SKDEADrgLVPPATAIALMGKSGSLLLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQILKISRCAVLGFG 440
Cdd:COG0591 292 PLADPD--LALPLLILELLPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVG 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 441 CFMGILAvvLNKAGVSLGWMYLAMGVLIGSAVIPIAFMLLWSKANAFGAILGATSGCVFGIITWLTTAKtqygrvdLDST 520
Cdd:COG0591 370 LLALLLA--LLFPSSILDLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLGGP-------LGPF 440
|
490 500
....*....|....*....|...
gi 334188207 521 GKNGPMLAGNLVAILTGGLIHAV 543
Cdd:COG0591 441 GWLYPILPGLLVSLLVFVVVSLL 463
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
45-513 |
4.43e-33 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 133.06 E-value: 4.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 45 FGAFFAVFTSFLVWLEKRYVGARHTSEWFNTAGRNVKTGLIASVIVSQWTWAATILQSSNVAWQYGVSGpFWYASGATIQ 124
Cdd:cd10322 2 DLIIVVVYLALLLGIGLYASKKVKSSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSA-IWYILGAALG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 125 VLLFGVMAIEIKRKAPNAHTVCEIVKARWGTATHIVFLVFCLATNVVVTAMLLLGGSAVVNALTGVNLYAASFLIPLGVV 204
Cdd:cd10322 81 ALLLALFLAPRLRRLGKTTIPETILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVIIAAVIVI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 205 VYTLAGGLKATFLASYVHSVIVHVALVVFVFLVYTSSKELGspsvvydrLKDMVAKsrsctepLSHHGQACGPVDGNFRG 284
Cdd:cd10322 161 LYTVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGGG--------FSALAAA-------LPALLLALGPGGGLGWS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 285 SYLTMlssggavfglinIVGNFGTVFVDNGYWVSAIAAR-PSSTHKGYLLGGLVWFAVPFSLATSLGLGALALDLPISKD 363
Cdd:cd10322 226 TILSL------------ILLTGLGVLALPQVFQRILAAKdEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPDLENPD 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 364 eadrgLVPPATAIALMGKSGSLLLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQILKISRCAVLGFGCFM 443
Cdd:cd10322 294 -----LALPTLINSLLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASDKKLLRVSRIAVVVVGVLA 368
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 444 GILAVvlnKAGVSLGWMYLAMGVLIGSAVIPIAFMLLWSKANAFGAILGATSGCVFGIITWLTTAKTQYG 513
Cdd:cd10322 369 LLLAL---LPPSILLLLSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPLASPLG 435
|
|
| SLC5sbd_u1 |
cd11477 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
39-540 |
7.65e-13 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271371 Cd Length: 493 Bit Score: 71.46 E-value: 7.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 39 YAVIlgfGAFFAVFTSFLVWLEKRyvGARHTSEWFnTAGRNVKTGLIASVIVSQWTWAATILQSSNVAWQYGVSGPFWYA 118
Cdd:cd11477 3 WLVI---ALYFLLMLGIGLWFSKR--ASKSTSDFF-LGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWW 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 119 SGAtIQVLLFGVMAIEIKRKAPNAHTVCEI---VKARWGTAT-HIVFLVFCLATNVVVTAMLLLGGSAVVNALTGVNLYA 194
Cdd:cd11477 77 LWA-VAGLIGAFVFARRWRRLRVLTDGEFPeerYGGRYGAPLrQFYAVYFALLSNVDILAWVFLAAIKVSAVFGPWDPWL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 195 ASFLIPLGVVVYTLAGGLKATFLASYVHSVIVhvaLVVFVFLVYTSSKELGSPSVVYDRLKDMvaksrscteplshhgqa 274
Cdd:cd11477 156 TILILGLITLIYTVIGGLWAVVVTDVVQFVIA---MAASIAVAVLALNAVGGPGGLFAQLPEG----------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 275 cgpvDGNFRGSYLTMLSSGGAVFGLINIVGNFGTVFVDNGYWVSAIAARPSSTHKG---------YLLGGLVWFAVPFSL 345
Cdd:cd11477 216 ----HLDLFGSGLGASGFYITFFFILFFGWYPLSYSGGGWYLAQRYLSAKSEKAAKaaawlfaalYLVRPWPWMLPALAA 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 346 AtslglgalaLDLPISKD-EADRGLVPPATAIALM--GKSGslLLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYINPR 422
Cdd:cd11477 292 L---------VLYPDLDDpEADFELAYPMMIKEYLpaGLLG--LVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRFIKPN 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 423 ATGRQILKISRCAVLGFGCFMGILAVVLNKAGvSLGWMYLAMGVLIGsavIPIAFMLLWSKANAFGAILGATSGCVFGII 502
Cdd:cd11477 361 ASEKHLLKVGRLATVLFGLLSIVVALASDSIG-GAFWIVLALGAGLG---GPLILPWLWWRFNAWTEIWAMIASIIVGLV 436
|
490 500 510
....*....|....*....|....*....|....*...
gi 334188207 503 TWLTtakTQYGRVDLDSTGKNGPMLAGNLVAILTGGLI 540
Cdd:cd11477 437 VSVL---LKVFGLPEDFLFSFLVPVLLSLVVWLAVTLL 471
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
73-496 |
8.63e-11 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 64.67 E-value: 8.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 73 FNTAGRNVKTGLIASVIVSQWTWAATILQSSNVAWQYGVSGpFWYASGATIQVLLFGVMAIEIKRKApNAHTVCEIVKAR 152
Cdd:pfam00474 1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAG-GLYAIGALVGVWLLLWLFAPRLRNL-GAYTMPDYLRKR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 153 WGTATHIVFLVFCLATNVVVTAML--LLGGSAVVNALTGVNLYAASFLIPLGVVVYTLAGGLKATFLASYVHSVIVHVAL 230
Cdd:pfam00474 79 FGGKRILVYLSALSLLLYFFTYMSvqIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 231 VVFVFLVYtssKELGSPSVVYDRLKDMVAKSRSCTEPLSHHGQAcgpvdgnfrgSYLTMLSSGGA----VFGLINIVGNF 306
Cdd:pfam00474 159 IILMIIVF---HEVGGYSSAVEKYMTADPNGVDLYTPDGLHILR----------DPLTGLSLWPGlvlgTTGLPHILQRC 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 307 gtvfvdngywvsaIAARPSST-HKGYLLgGLVWFAVPFSLATSLGLGALALDLPISK----DEADRGLVPPATAIALMGK 381
Cdd:pfam00474 226 -------------LAAKDAKCiRCGVLI-LTPMFIIVMPGMISRGLFAIALAGANPRacgtVVGCSNIAYPTLAVKLGPP 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 382 SGSLLLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYINP-RATGRQILKISRCAVLGFGCFMGILAVVLNKAGVsLGWM 460
Cdd:pfam00474 292 GLAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKaSATEKELVGRSRIIVLVVISLAILLAVQPAQMGI-AFLV 370
|
410 420 430
....*....|....*....|....*....|....*..
gi 334188207 461 YLAMGVLiGSAVIP-IAFMLLWSKANAFGAILGATSG 496
Cdd:pfam00474 371 QLAFAGL-GSAFLPvILLAIFWKRVNEQGALWGMIIG 406
|
|
| SLC5sbd_u2 |
cd11478 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
47-512 |
1.09e-10 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271372 Cd Length: 496 Bit Score: 64.62 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 47 AFFAVFTSFLVWLEKRYVgarHTSEWFNTAGRNVKTGLIASVIVSQWTWAATILQSSNVAWQYGVSGPFWYASGATIQVL 126
Cdd:cd11478 7 AVYFVFVLGIGFYLKRKV---KTSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGIATVHFYWIGAIPAMV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 127 LFGVMAIEIKRKApNAHTVCEIVKARWGTATHIVFLVFCLATNVVVTAMLLLGGSAVVNALTGVNLYAASFLIPLGVVVY 206
Cdd:cd11478 84 FLGIVMMPFYYGS-KVRSVPEYLKLRFNKSTRLLNAVSFAVMTILMSGINLYALALVLNVLLGWPLWLSIILSAAIVLAY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 207 TLAGGLKATFLASYVHSVIVhvaLVVFVFLVYTSSKELGSpsvvYDRLKDMVAKSrsctEPLSHHGQACGPVDGNFRGSY 286
Cdd:cd11478 163 TTLGGLTSAIYNEVLQFFLI---VAGLIPLVIIGLIKVGG----WDGLSEKIDAN----GPPGWNGLSWGPQGSQSTNPM 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 287 ltmlssgGAVFGLInivgnFGTVFV-DNGYWVS-------AIAARP-SSTHKGYLLGGLVWFAVPFsLATSLGLGALALD 357
Cdd:cd11478 232 -------GVNLGLV-----FGLGFVlSFGYWTTnflevqrAMAAKDlSAARRTPLIAAFPKMFIPF-LVILPGLIALVLV 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 358 LPISkdeADRGLVPPATAIALMGK---SGSL-LLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQILKISR 433
Cdd:cd11478 299 PELG---ASGGLDYNQALPYLMAKylpPGLLgLGITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVKDAPDKHYLKVGR 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 434 CAVLGfGCFMGILAVVLNKagvSLGWMYLAMGVLIGSAVIPI--AFML--LWSKANAFGAILGATSGCVFGIITWLTTAK 509
Cdd:cd11478 376 IATVV-GVLISIGTAYIAS---SFNNIMDYLQLLFSFFNAPLfaTFLLgmFWKRATPWGGFWGLLAGTASAIVLYGLYEL 451
|
...
gi 334188207 510 TQY 512
Cdd:cd11478 452 GLI 454
|
|
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
363-505 |
3.92e-10 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 62.54 E-value: 3.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 363 DEADRGLVPPATAIALMGKSGSLLLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQILKISRCAVLGFGCF 442
Cdd:cd11474 291 LEEDAQLILPLLLQYLTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAI 370
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334188207 443 MGILAvvLNKAGVSLGWmYLAMGVLIGSAVIPIAFMLLWSKANAFGAILGAtsgcVFGIITWL 505
Cdd:cd11474 371 ATLMA--LTVESIYGLV-ELASDLVLVGLFVPLLAGLYWKRANTYGALAAI----IVGLVLRL 426
|
|
| YidK |
COG4146 |
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ... |
386-504 |
4.09e-10 |
|
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];
Pssm-ID: 443317 [Multi-domain] Cd Length: 444 Bit Score: 62.47 E-value: 4.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 386 LLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQILKISRCAVLGFGCFMGILAVVLNKAGVslGWMYLAMg 465
Cdd:COG4146 326 LVAAALFAAIMSSLASALNSSSTLFTLDIYKKYFNPNASEKQLVKVGRIATVVLAVIAILIAPLIGNADG--LFQYIQE- 402
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 334188207 466 vLIGSAVIPIAFM----LLWSKANAFGAILGATSGCVFGIITW 504
Cdd:COG4146 403 -VTGFFSPPILAVfllgLFWKRVTAKAAKVALIAGIVLSILLK 444
|
|
| SLC5sbd_NIS-like_u2 |
cd11494 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
386-505 |
1.76e-08 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 57.61 E-value: 1.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 386 LLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQILKISRCAVLGFGCFMGILAVVlnkaGVSLGWMYLAMG 465
Cdd:cd11494 329 LLIAAIFAAAMSSIDSALNSLATVTVIDIYRRFFKKDASDEHYLKVSRLLTVFWGLLAIVFALF----AGLAGSLIEAVN 404
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 334188207 466 VLIGSAVIPI--AFML--LWSKANAFGAILGATSGCVFGIITWL 505
Cdd:cd11494 405 KLGSLFYGPIlgVFLLafFTKKANGKGVFAGAILGVIVVIVLWL 448
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
45-499 |
2.61e-08 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 56.74 E-value: 2.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 45 FGAFFAVFTSFLV---WLEKRyvgARHTSEwFNTAGRNVKTGLIASVIVSQWTWAATILQSSNVAWQYGVSGpFWYASGA 121
Cdd:cd11480 1 IGLFFVFVTITLYitiWAARR---TRSTSD-FYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYDG-LAYAIGW 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 122 TIQVLLFGVMAIEIKRKApNAHTVCEIVKARWGTAThiVFLVFCLATNVVVTAML---LLGGSAVVNALTGVNLYAASFL 198
Cdd:cd11480 76 TGGYVLLLLLVAEPLRNF-GKYTVPDFLGARLGSRP--VRLVAAVSTLVISFFYLvaqMVGAGLLLSLLLGIPYEVGVVV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 199 IPLGVVVYTLAGGLKAT----------FLASYVHSVIVHVALVVFVFLVYTSSKELGSPSVVYDRLKDMVAksrsctepl 268
Cdd:cd11480 153 VGALMIVYVVLGGMRATtwvqiiqyvlLLGAFLVPAILVLARFGGNPLGAGPGLLGLAAAAASGAGEAYLA--------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 269 shhgqacgpvDGNFRGSYLTMLSSGGAVF----GLINIVGNFGTVfvdngywVSAIAARpSSTHKG-------YLLGGLV 337
Cdd:cd11480 224 ----------PGLLLTDPLDVISLTLALMlgtaGLPHVLMRFYTV-------PDARAAR-KSVVWAlgfiglfYLLAPAL 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 338 WFAVPFSLATSLGLGALALDLPISKDEAdrglVPPATAIALMGKSGSLLLLTMLFMAVTSAGSSELIAVSSLFTYDIYRT 417
Cdd:cd11480 286 GFGARALVGPDVIGAPIAGELDGGGDMA----VLLLPEIAGLGDLLLALVAAGAFAAILATVAGLLLAAASALAHDLYAG 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 418 YINPRATGRQILKISRCAVLGFGCFMGILAVVLNKAGVS--LGWmylAMGVlIGSAVIPIAFM-LLWSKANAFGAILGAT 494
Cdd:cd11480 362 VIRPGASERREVRVARIAAVVVGVIAILLALLFPPQNVAflVAL---AFAI-AASAFFPVLVLgIFWRRFTTRGAIAGML 437
|
....*
gi 334188207 495 SGCVF 499
Cdd:cd11480 438 VGLLV 442
|
|
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
105-513 |
3.88e-07 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 53.28 E-value: 3.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 105 VAWQYGVSGpFWYASGATIQVLL-FGVMAIEIKR--KAPNAHTVCEIVKARWGTATHI------VFLVFCLatnVVVTAM 175
Cdd:cd11475 60 AAYASGLSA-IWIAIGLILGAYLnWLFVAKRLRRytEKNDSITLPDYLENRFRDKSKLlrilsaLIILIFF---TIYAAA 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 176 LLLGGSAVVNALTGVNLYAASFLIPLGVVVYTLAGGLKATFLASYVHSVIVHVALVVFVFLVYTSskeLGSPSVVYDRLK 255
Cdd:cd11475 136 QLVAGGKLFESLFGIDYSTGLLIGAVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAA---LGGLSGLVAALA 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 256 DMVAksrscteplshhgqacgpvdgnfrgSYLTMLSSGGAVFGLINIVGNFGTVFvdnGYW------VSAIAARPSSTHK 329
Cdd:cd11475 213 AIDP-------------------------GLLSPFGGDLGAGGLLAIISLLAWGL---GYFgqphilVRFMAIRSPKEIK 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 330 GYLLGGLVWFAVPFSLATSLGLGALALDLPISKDEADrgLVPPATAIALMGKSGSLLLLTMLFMAVTSAGSSELIAVSSL 409
Cdd:cd11475 265 KARRIAMVWMILFLLGAVLVGLLGRALFPDGLLGDPE--TVFPVLAQELFPPWLAGILLAAILAAIMSTADSQLLVCSSA 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 410 FTYDIYRTYINPRATGRQILKISRCAVLGFGCFMGILAVVLNKAGVSLGWMylAMGVLiGSAVIP-IAFMLLWSKANAFG 488
Cdd:cd11475 343 LTEDLYKAFLRKEASDKELVWVSRLAVLVIALIALLIALNPPSSVFSLVSF--AWAGL-GAAFGPlLLLSLYWKRTTRQG 419
|
410 420
....*....|....*....|....*
gi 334188207 489 AILGATSGCVFGIItWLTTAKTQYG 513
Cdd:cd11475 420 ALAGMIAGAVTVVV-WKLLGLGIFG 443
|
|
| SLC5sbd_u3 |
cd11479 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
386-500 |
4.32e-07 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271373 Cd Length: 454 Bit Score: 52.99 E-value: 4.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 386 LLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQILKISRCAVLGFGCFMGILAVVLNKAGVSLGwmyLAMG 465
Cdd:cd11479 306 LVLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESERSEVRLSRLFTLLLGVVVIVIAVLVNDVVAALT---IAYA 382
|
90 100 110
....*....|....*....|....*....|....*..
gi 334188207 466 VLIGSAVIPIAFMLLWSKANAFGAI--LGATSGCVFG 500
Cdd:cd11479 383 ILVGGLLVPILGGLFWKRATGAGALasMVAGSVVVLA 419
|
|
| SLC5sbd_vSGLT |
cd10325 |
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ... |
386-507 |
8.44e-05 |
|
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271360 Cd Length: 523 Bit Score: 45.76 E-value: 8.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 386 LLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQILKISRCAVLGFGCFMGILAVVLNKAGVSLGWMYLAMG 465
Cdd:cd10325 333 LVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIPKKASEKQLVNVGRLAAVIALIIAALIAPPLLGLDQAFQYIQEYTG 412
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 334188207 466 vLIGSAVIPIAFM-LLWSKANAFGAILGATSGCVFGIITWLTT 507
Cdd:cd10325 413 -FISPGILAIFLLgLFWKRATSAGALVAAILSIVLSALFKFLL 454
|
|
| PRK10484 |
PRK10484 |
putative transporter; Provisional |
391-503 |
1.53e-04 |
|
putative transporter; Provisional
Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 44.87 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 391 LFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQILKISRCAVLGFGCFMGILAVVLNKAGVSLgwmYLAMGVLIGS 470
Cdd:PRK10484 336 LFGAILSTFNGFLNSASTLFSLDIYKPIINPNASEKQLVKVGKKFGFVLAIISMIVAPLIANAPQGL---YSYLQQLNGI 412
|
90 100 110
....*....|....*....|....*....|....*..
gi 334188207 471 AVIPIAFM----LLWSKANAFGAILGATSGCVFGIIT 503
Cdd:PRK10484 413 YNVPILAIiivgFFTKRVPALAAKVALGFGIILYIII 449
|
|
| SLC5sbd_YidK |
cd10328 |
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ... |
390-512 |
1.74e-04 |
|
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271362 Cd Length: 472 Bit Score: 44.83 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 390 MLFMAVTSAGSSELIAVSSLFTYDIYRTYINPRATGRQILKISRCAVLGFGCFMGILAVVLNKAGVSLgwmYLAMGVLIG 469
Cdd:cd10328 329 VLFGAILSSFNSALNSAATLFSLDIYKPIINKNATDKQLVKVGKIFGIVLALISMIIAPFIAYAPEGL---FNYLQQFNG 405
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 334188207 470 SAVIPIAFM----LLWSKANAFGAILGATSGCVF-GIITWLTTAKTQY 512
Cdd:cd10328 406 FFSIPILAIvlvgFFTKRVPALAAKIALIFGVILyALLQFVFLVPIHF 453
|
|
| SLC5sbd_SGLT1-like |
cd10329 |
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ... |
386-607 |
3.67e-04 |
|
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271363 Cd Length: 538 Bit Score: 43.72 E-value: 3.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 386 LLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTyINPRATGRQILKISRCAVLgFGCFMGIL-AVVLNKAGVSLgWMYLAm 464
Cdd:cd10329 325 LVLAVLLAALMSSLTSIFNSASTLFTMDIYKR-LRPEASEKELVRVGRIATL-VVVVISILwAPIIQAQGGSL-FNYIQ- 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 465 gVLIGSAVIPIA--FML--LWSKANAFGAILGATSGCVFGIItwLTTAKTQYGRVDLDSTGKNGP--MLAGNLVAILTgG 538
Cdd:cd10329 401 -SVLSYLAPPIAavFLLgiFWKRTNEQGAFWGLIAGLVLGLV--RLILEFAYGEPDTRPAIIGGIhfLYFAFLLFVVS-V 476
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334188207 539 LIHAVCSLVRPqnydwsttreiKVVEAYASGDEDVDVPAEELREEKLRRAKAWIVKWGLVFTILIVVIW 607
Cdd:cd10329 477 IVTVIVSLLTP-----------PPPAEKLAGLTWSTRLTKETSTLERPPWYKNVRILAILLLALTIFLY 534
|
|
| SLC5sbd_PanF |
cd10327 |
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
41-214 |
4.02e-04 |
|
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212037 Cd Length: 472 Bit Score: 43.35 E-value: 4.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 41 VILGFGAFFAVFTSFLVWLeKRYVGARHTS---EWFnTAGRNVKTGLIASVIVSQWTWAATILQSSNVAWQYGVSGPFWy 117
Cdd:cd10327 1 VLLPIIIYLVILLGIGFYA-RRSKKRRSGDfleEYF-IGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGWVLL- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 118 asgATIQV----LLFGV----MAIeIKRKApNAHTVCEIVKAR-------WGTAthIVFLVFCLATNVVvtamLLLGGSA 182
Cdd:cd10327 78 ---AMIQVptgfLTLGVlgkkFAI-IARKI-NAVTIIDYLRARynskalvVLSS--LALIVFFIAAMVA----QFIGGAR 146
|
170 180 190
....*....|....*....|....*....|..
gi 334188207 183 VVNALTGVNLYAASFLIPLGVVVYTLAGGLKA 214
Cdd:cd10327 147 LLEAVTGLSYVTGLLIFGLTVILYTTIGGFRA 178
|
|
| SLC5sbd_SGLT5 |
cd11489 |
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ... |
372-501 |
4.72e-03 |
|
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212058 Cd Length: 604 Bit Score: 40.31 E-value: 4.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188207 372 PATAIALMGKSGSLLLLTMLFMAVTSAGSSELIAVSSLFTYDIYRTYiNPRATGRQILKISRCAVLGFGCFMGILAVVLN 451
Cdd:cd11489 338 PKLVMELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRRL-RPGASERELLLVGRLVTVILVGVSVVWIPILQ 416
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 334188207 452 KAGVslGWMYLAMGVLIGSAVIPIA--FML--LWSKANAFGAILGATSGCVFGI 501
Cdd:cd11489 417 SSNS--GQLYIYIQSVTSYLAPPVTavFVLavFWRRANEQGAFWGLMAGLVVGL 468
|
|
| |
