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Conserved domains on  [gi|15238908|ref|NP_199628|]
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F-box family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
31-71 7.10e-15

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438922  Cd Length: 44  Bit Score: 64.65  E-value: 7.10e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15238908  31 HHDVLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEELC 71
Cdd:cd22151   4 PDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENAC 44
 
Name Accession Description Interval E-value
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
31-71 7.10e-15

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 64.65  E-value: 7.10e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15238908  31 HHDVLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEELC 71
Cdd:cd22151   4 PDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENAC 44
F-box-like pfam12937
F-box-like; This is an F-box-like family.
32-71 4.03e-08

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 47.09  E-value: 4.03e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 15238908    32 HDVLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEELC 71
Cdd:pfam12937   6 DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
33-70 9.56e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 37.80  E-value: 9.56e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 15238908     33 DVLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEEL 70
Cdd:smart00256   4 EILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
31-71 7.10e-15

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 64.65  E-value: 7.10e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15238908  31 HHDVLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEELC 71
Cdd:cd22151   4 PDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENAC 44
F-box-like pfam12937
F-box-like; This is an F-box-like family.
32-71 4.03e-08

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 47.09  E-value: 4.03e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 15238908    32 HDVLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEELC 71
Cdd:pfam12937   6 DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
38-71 1.98e-06

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 42.68  E-value: 1.98e-06
                        10        20        30
                ....*....|....*....|....*....|....
gi 15238908  38 ILRRLDGSSLCSAACVCRLWSAVARNDSIWEELC 71
Cdd:cd22147  13 ILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
33-71 8.18e-06

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 40.78  E-value: 8.18e-06
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15238908  33 DVLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEELC 71
Cdd:cd22109   9 DALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
34-72 4.37e-05

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 38.77  E-value: 4.37e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15238908  34 VLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEELCF 72
Cdd:cd22093   8 ILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKLYS 46
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
34-70 5.52e-05

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 5.52e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 15238908  34 VLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEEL 70
Cdd:cd22132   8 LLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKEL 44
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
36-71 7.85e-05

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 38.45  E-value: 7.85e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 15238908  36 VEILRRLDGSSLCSAACVCRLWSAVARN-DSIWEELC 71
Cdd:cd22113  10 LRIFSQLDVQSLCRASQTCKTWNDLIENsDYLWRPHC 46
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
32-62 8.43e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 37.81  E-value: 8.43e-05
                        10        20        30
                ....*....|....*....|....*....|.
gi 15238908  32 HDVLVEILRRLDGSSLCSAACVCRLWSAVAR 62
Cdd:cd09917   5 DEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
33-70 9.56e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 37.80  E-value: 9.56e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 15238908     33 DVLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEEL 70
Cdd:smart00256   4 EILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
32-68 4.77e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 35.98  E-value: 4.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 15238908    32 HDVLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWE 68
Cdd:pfam00646   6 DDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
F-box_FBXW8 cd22134
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ...
24-71 2.96e-03

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438906  Cd Length: 48  Bit Score: 34.27  E-value: 2.96e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 15238908  24 PVFSINDHHDVLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEELC 71
Cdd:cd22134   1 PFFDIQLPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRIC 48
F-box_FBXW1B cd22183
F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; ...
30-69 3.05e-03

F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438954  Cd Length: 51  Bit Score: 34.11  E-value: 3.05e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15238908  30 DHhdVLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEE 69
Cdd:cd22183  14 DH--IAENILSYLDAESLCAAELVCKEWQRVISEGMLWKK 51
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
33-65 3.07e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 33.59  E-value: 3.07e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 15238908  33 DVLVEILRRLDGSSLCSAACVCRLWSAVARNDS 65
Cdd:cd22157   6 DLVEEILSRLPAKSLLRFRCVCKQWNSLISSPS 38
F-box_FBXO8 cd22088
F-box domain found in F-box only protein 8 (FBXO8) and similar proteins; FBXO8, also called ...
33-71 3.25e-03

F-box domain found in F-box only protein 8 (FBXO8) and similar proteins; FBXO8, also called FBX8, or F-box/SEC7 protein FBS, is a novel component of F-box proteins which contains an F-box domain and a putative Sec7 domain. FBX8 was originally identified as a Skp1-binding protein. It is involved in the ubiquitin-dependent proteolytic pathway. It acts as a metastasis suppressor that functions through mTOR signaling pathway. FBXO8 may promote the activation of ADP-ribosylation factor (ARF) through replacement of GDP with GTP. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438860  Cd Length: 46  Bit Score: 33.84  E-value: 3.25e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15238908  33 DVLVEILRRLDGSSLCSAACVcrlWSAVARNDSIWEELC 71
Cdd:cd22088  10 ELSLTVLSHLNATDLCLASCV---WQDLANDELLWQGLC 45
F-box_FBXO11 cd22091
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ...
33-70 3.66e-03

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438863  Cd Length: 45  Bit Score: 33.93  E-value: 3.66e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15238908  33 DVLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEEL 70
Cdd:cd22091   7 EVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKRL 44
F-box_FBXW1A cd22182
F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; ...
38-75 7.38e-03

F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438953  Cd Length: 60  Bit Score: 33.50  E-value: 7.38e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15238908  38 ILRRLDGSSLCSAACVCRLWSAVARNDSIWEELCFRQV 75
Cdd:cd22182  22 ILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMV 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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