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Conserved domains on  [gi|79532250|ref|NP_199711|]
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Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

Protein Classification

F-box/kelch-repeat protein( domain architecture ID 17778853)

F-box/kelch-repeat protein may be a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50|2.120.10.80
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515|GO:0016567
PubMed:  10603472|31898225|11178263|31442578|24959344|10581972
SCOP:  4001927|3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 23-65 2.01e-15

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438923  Cd Length: 45  Bit Score: 69.13  E-value: 2.01e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 79532250  23 PSLPDDLIVSILARVSRLYYPILSLVSKSSRTLVTSPELYKTR 65
Cdd:cd22152   3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
112-245 2.31e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.03  E-value: 2.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79532250 112 TWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDSSKWMEVFDIKTQTWEFVLS-PLAERFIYRSLVIEGEIYIFG---- 186
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPlPGPPRHHAAAVAQDGKLYVFGgftg 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 79532250 187 --------DKVVTYKPKEDRWGGVGehqSMDLGLFFHSYCVIDNVLY----CYRPGGIKW---YESEKRSWRKL 245
Cdd:COG3055  82 anpsstplNDVYVYDPATNTWTKLA---PMPTPRGGATALLLDGKIYvvggWDDGGNVAWvevYDPATGTWTQL 152
 
Name Accession Description Interval E-value
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 23-65 2.01e-15

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 69.13  E-value: 2.01e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 79532250  23 PSLPDDLIVSILARVSRLYYPILSLVSKSSRTLVTSPELYKTR 65
Cdd:cd22152   3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
112-245 2.31e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.03  E-value: 2.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79532250 112 TWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDSSKWMEVFDIKTQTWEFVLS-PLAERFIYRSLVIEGEIYIFG---- 186
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPlPGPPRHHAAAVAQDGKLYVFGgftg 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 79532250 187 --------DKVVTYKPKEDRWGGVGehqSMDLGLFFHSYCVIDNVLY----CYRPGGIKW---YESEKRSWRKL 245
Cdd:COG3055  82 anpsstplNDVYVYDPATNTWTKLA---PMPTPRGGATALLLDGKIYvvggWDDGGNVAWvevYDPATGTWTQL 152
PHA03098 PHA03098
kelch-like protein; Provisional
 109-242 3.00e-09

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 57.86  E-value: 3.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79532250  109 GSHTWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDSS-KWMEVFDIKTQTWEfVLSPLAERFIYRSLVI-EGEIYIFG 186
Cdd:PHA03098 366 GESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELlKTVECFSLNTNKWS-KGSPLPISHYGGCAIYhDGKIYVIG 444

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 79532250  187 -----------DKVVTYKPKEDRWggvGEHQSMDLGLFFHSYCVIDNVLYCYrpGGIKW---------YESEKRSW 242
Cdd:PHA03098 445 gisyidnikvyNIVESYNPVTNKW---TELSSLNFPRINASLCIFNNKIYVV--GGDKYeyyineievYDDKTNTW 515
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 123-163 8.66e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 47.99  E-value: 8.66e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 79532250   123 RNYPAANVVDGKIYVAGGLEEFDSSKWMEVFDIKTQTWEFV 163
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 24-64 1.01e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 44.84  E-value: 1.01e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 79532250    24 SLPDDLIVSILARVSRLYYPILSLVSKSSRTLVTSPELYKT 64
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
FBOX smart00256
A Receptor for Ubiquitination Targets;
25-65 1.22e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.88  E-value: 1.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 79532250     25 LPDDLIVSILARVSRLYYPILSLVSKSSRTLVTSPELYKTR 65
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 23-65 2.01e-15

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 69.13  E-value: 2.01e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 79532250  23 PSLPDDLIVSILARVSRLYYPILSLVSKSSRTLVTSPELYKTR 65
Cdd:cd22152   3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
112-245 2.31e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.03  E-value: 2.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79532250 112 TWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDSSKWMEVFDIKTQTWEFVLS-PLAERFIYRSLVIEGEIYIFG---- 186
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPlPGPPRHHAAAVAQDGKLYVFGgftg 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 79532250 187 --------DKVVTYKPKEDRWGGVGehqSMDLGLFFHSYCVIDNVLY----CYRPGGIKW---YESEKRSWRKL 245
Cdd:COG3055  82 anpsstplNDVYVYDPATNTWTKLA---PMPTPRGGATALLLDGKIYvvggWDDGGNVAWvevYDPATGTWTQL 152
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
110-186 1.79e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 60.55  E-value: 1.79e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 79532250 110 SHTWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDSSKWMEVFDIKTQTWEfVLSPLAERFIYRS--LVIEGEIYIFG 186
Cdd:COG3055  99 TNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWT-QLAPLPTPRDHLAaaVLPDGKILVIG 176
PHA03098 PHA03098
kelch-like protein; Provisional
 109-242 3.00e-09

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 57.86  E-value: 3.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79532250  109 GSHTWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDSS-KWMEVFDIKTQTWEfVLSPLAERFIYRSLVI-EGEIYIFG 186
Cdd:PHA03098 366 GESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELlKTVECFSLNTNKWS-KGSPLPISHYGGCAIYhDGKIYVIG 444

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 79532250  187 -----------DKVVTYKPKEDRWggvGEHQSMDLGLFFHSYCVIDNVLYCYrpGGIKW---------YESEKRSW 242
Cdd:PHA03098 445 gisyidnikvyNIVESYNPVTNKW---TELSSLNFPRINASLCIFNNKIYVV--GGDKYeyyineievYDDKTNTW 515
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
107-186 6.51e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 55.93  E-value: 6.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79532250 107 SSGSHTWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDSSkwMEVFDIKTQTWEfVLSPL-AERFIYRSLVIEGEIYIF 185
Cdd:COG3055 181 SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDE--VEAYDPATNTWT-ALGELpTPRHGHAAVLTDGKVYVI 257


                .
gi 79532250 186 G 186
Cdd:COG3055 258 G 258
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
112-231 8.12e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 52.85  E-value: 8.12e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79532250 112 TWHEAPSMRMKRNYP-AANVVDGKIYVAGGLEefdsskwmevFDIKTQTWEFVLSPLAERFIYRSLVIEGEIYIFG---- 186
Cdd:COG3055 148 TWTQLAPLPTPRDHLaAAVLPDGKILVIGGRN----------GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGgesg 217

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 79532250 187 --DKVVTYKPKEDRWGGVGEhqsMDLGLFFHSYCVIDNVLYCyrPGG 231
Cdd:COG3055 218 fsDEVEAYDPATNTWTALGE---LPTPRHGHAAVLTDGKVYV--IGG 259
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 123-163 8.66e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 47.99  E-value: 8.66e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 79532250   123 RNYPAANVVDGKIYVAGGLEEFDSSKWMEVFDIKTQTWEFV 163
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 24-64 1.01e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 44.84  E-value: 1.01e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 79532250    24 SLPDDLIVSILARVSRLYYPILSLVSKSSRTLVTSPELYKT 64
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
F-box_ScMDM30-like cd22143
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ...
 24-65 2.01e-04

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438915  Cd Length: 44  Bit Score: 38.36  E-value: 2.01e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 79532250  24 SLPDDLIVSILARVSRLYYPILSLVSKSSRTLVTsPELYKTR 65
Cdd:cd22143   4 SLPDEILSIIFSHLPQSDLYNLLFVNKHFYSLAL-PELWRSI 44
PHA03098 PHA03098
kelch-like protein; Provisional
 113-225 6.27e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 41.29  E-value: 6.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79532250  113 WHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDSSKWMEVFDIKTQTWEFVLSPLAERFIYRSLVIEGEIYIFG------ 186
Cdd:PHA03098 323 WNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGgisknd 402

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 79532250  187 ---DKVVTYKPKEDRWggvGEHQSMDLGLFFHSYCVIDNVLY 225
Cdd:PHA03098 403 ellKTVECFSLNTNKW---SKGSPLPISHYGGCAIYHDGKIY 441
Kelch_6 pfam13964
Kelch motif;
123-163 9.62e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.54  E-value: 9.62e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 79532250   123 RNYPAANVVDGKIYVAGGLE-EFDSSKWMEVFDIKTQTWEFV 163
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTnASPALNKLEVYNPLTKSWEEL 43
FBOX smart00256
A Receptor for Ubiquitination Targets;
25-65 1.22e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.88  E-value: 1.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 79532250     25 LPDDLIVSILARVSRLYYPILSLVSKSSRTLVTSPELYKTR 65
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
PHA03098 PHA03098
kelch-like protein; Provisional
 112-167 1.26e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 40.52  E-value: 1.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 79532250  112 TWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDSSKWMEVFDIKTQTWEFVLSPL 167
Cdd:PHA03098 467 KWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFP 522
PRK14131 PRK14131
N-acetylneuraminate epimerase;
122-186 4.00e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 38.46  E-value: 4.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79532250  122 KRNYPAANVVDGKIYVAGGLEEFDSSKWMEVF------DIKTQTWEFVL--SPlaerfiyRSLVI-------EGEIYIFG 186
Cdd:PRK14131  74 PREQAVAAFIDGKLYVFGGIGKTNSEGSPQVFddvykyDPKTNSWQKLDtrSP-------VGLAGhvavslhNGKAYITG 146
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 23-60 5.92e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 33.97  E-value: 5.92e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 79532250  23 PSLPDDLIVSILARVsrlyyPILSL-----VSKSSRTLVTSPE 60
Cdd:cd22157   1 SSLPDDLVEEILSRL-----PAKSLlrfrcVCKQWNSLISSPS 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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