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Conserved domains on  [gi|15239780|ref|NP_199716|]
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universal stress A-like protein [Arabidopsis thaliana]

Protein Classification

adenine nucleotide alpha hydrolase family protein( domain architecture ID 188)

AANH (adenine nucleotide alpha hydrolase) family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AANH_superfamily super family cl00292
Adenine nucleotide alpha hydrolase (AANH) superfamily; The adenine nucleotide alpha hydrolase ...
 39-150 1.19e-12

Adenine nucleotide alpha hydrolase (AANH) superfamily; The adenine nucleotide alpha hydrolase (AANH) superfamily includes N-type ATP PPases, ATP sulfurylases, universal stress response proteins (USPs), and electron transfer flavoproteins (ETFs). The domain forms an alpha/beta/alpha fold which binds to adenosine nucleotide.


The actual alignment was detected with superfamily member cd23659:

Pssm-ID: 469708  Cd Length: 143  Bit Score: 61.10  E-value: 1.19e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239780  39 RVVVVGVDDSAHSYHALETALDLFFIpfkanPRFKLVVLHARPTATFFLGVAGPGTVDIIPMVEEDLNKTADLVKK---K 115
Cdd:cd23659   1 RKVLIAVDGSEESEYALEWALENLHR-----PGDEVVLLHVIEPPSLPAASLGSGSEEWEALEEEAREKAEKLLEKyekK 75

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15239780 116 CAEVCSAKSVeissLEVIEGDPRNIMLEAVERHHA 150
Cdd:cd23659  76 LKEEKGIKVK----VEVVAGDPGEVICKAAEELKA 106
 
Name Accession Description Interval E-value
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 39-150 1.19e-12

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 61.10  E-value: 1.19e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239780  39 RVVVVGVDDSAHSYHALETALDLFFIpfkanPRFKLVVLHARPTATFFLGVAGPGTVDIIPMVEEDLNKTADLVKK---K 115
Cdd:cd23659   1 RKVLIAVDGSEESEYALEWALENLHR-----PGDEVVLLHVIEPPSLPAASLGSGSEEWEALEEEAREKAEKLLEKyekK 75

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15239780 116 CAEVCSAKSVeissLEVIEGDPRNIMLEAVERHHA 150
Cdd:cd23659  76 LKEEKGIKVK----VEVVAGDPGEVICKAAEELKA 106
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
41-150 2.92e-07

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 46.84  E-value: 2.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239780  41 VVVGVDDSAHSYHALETALDLFfipfkanPRF--KLVVLHARPTatfflgvaGPGTVDIIPMVEEDLNKTADLVKKKCAE 118
Cdd:COG0589   5 ILVPTDGSEEAERALEYAAELA-------KALgaELHLLHVVDP--------PPSAAAGPEELEEELREEAEEALEEAAE 69

                        90       100       110
                ....*....|....*....|....*....|..
gi 15239780 119 VCSAKSVEISSlEVIEGDPRNIMLEAVERHHA 150
Cdd:COG0589  70 RLEEAGVEVET-VVREGDPAEAILEAAEELDA 100
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 41-150 3.62e-06

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 43.94  E-value: 3.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239780    41 VVVGVDDSAHSYHALETALDLFfipfkANPRFKLVVLHARPTATFFLGVAGPGTVDIIPMVEEDLNKTADLVKKKCAEVc 120
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELA-----KARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEAG- 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 15239780   121 saksVEISSLEVIEGDPRNIMLEAVERHHA 150
Cdd:pfam00582  75 ----GVKVEVVVVVGDPAEEILEVAEEEDA 100
 
Name Accession Description Interval E-value
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 39-150 1.19e-12

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 61.10  E-value: 1.19e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239780  39 RVVVVGVDDSAHSYHALETALDLFFIpfkanPRFKLVVLHARPTATFFLGVAGPGTVDIIPMVEEDLNKTADLVKK---K 115
Cdd:cd23659   1 RKVLIAVDGSEESEYALEWALENLHR-----PGDEVVLLHVIEPPSLPAASLGSGSEEWEALEEEAREKAEKLLEKyekK 75

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15239780 116 CAEVCSAKSVeissLEVIEGDPRNIMLEAVERHHA 150
Cdd:cd23659  76 LKEEKGIKVK----VEVVAGDPGEVICKAAEELKA 106
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
41-150 2.92e-07

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 46.84  E-value: 2.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239780  41 VVVGVDDSAHSYHALETALDLFfipfkanPRF--KLVVLHARPTatfflgvaGPGTVDIIPMVEEDLNKTADLVKKKCAE 118
Cdd:COG0589   5 ILVPTDGSEEAERALEYAAELA-------KALgaELHLLHVVDP--------PPSAAAGPEELEEELREEAEEALEEAAE 69

                        90       100       110
                ....*....|....*....|....*....|..
gi 15239780 119 VCSAKSVEISSlEVIEGDPRNIMLEAVERHHA 150
Cdd:COG0589  70 RLEEAGVEVET-VVREGDPAEAILEAAEELDA 100
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 41-150 3.62e-06

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 43.94  E-value: 3.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239780    41 VVVGVDDSAHSYHALETALDLFfipfkANPRFKLVVLHARPTATFFLGVAGPGTVDIIPMVEEDLNKTADLVKKKCAEVc 120
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELA-----KARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEAG- 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 15239780   121 saksVEISSLEVIEGDPRNIMLEAVERHHA 150
Cdd:pfam00582  75 ----GVKVEVVVVVGDPAEEILEVAEEEDA 100
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 41-150 1.33e-05

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 42.33  E-value: 1.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239780  41 VVVGVDDSAHSYHALETALDLffipfKANPRFKLVVLHARPTATFflgvagPGTVDIIPMVEEDLNKTADLVKKKCAEVC 120
Cdd:cd00293   2 ILVAVDGSEESERALEWALEL-----AKRPGAELTLLHVVDPPPS------SSLSGGLEELADELKEEAEELLEEAKKLA 70

                        90       100       110
                ....*....|....*....|....*....|
gi 15239780 121 SAKSVEISSlEVIEGDPRNIMLEAVERHHA 150
Cdd:cd00293  71 EEAGVEVET-IVVEGDPAEAILEEAKELGA 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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