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Conserved domains on  [gi|15240616|ref|NP_199823|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
27-384 1.55e-49

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.02  E-value: 1.55e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  27 HQCIATLVCHTaSYISSLTLA--GKRLYTGSNDGVVRLWNANTLETLAEAssngdvitgeRGGGGAVKSLVILAD--KLF 102
Cdd:COG2319 110 GLLLRTLTGHT-GAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTL----------TGHSGAVTSVAFSPDgkLLA 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 103 TAHQDHKIRVWKINDvveedvggkkymhlatmptisdrfAKCLmpknqveirrhkkASWVHHVDAVSGLALSRDGTLLYS 182
Cdd:COG2319 179 SGSDDGTVRLWDLAT------------------------GKLL-------------RTLTGHTGAVRSVAFSPDGKLLAS 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 183 VSWDRTLKIWRTTDFKCLESFTnAHDDAINAVALSENGD-IYTGSSDQRIKVWrknineeNVKKKRkhsLVAILSEHNSG 261
Cdd:COG2319 222 GSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRlLASGSADGTVRLW-------DLATGE---LLRTLTGHSGG 290

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 262 INALALSGtNGSLLHSGGSDGSILVWERDDGGDIVVvgmLRGHTESVLCLAVVSD--ILCSGSADKTVRLWkcSAKDYSC 339
Cdd:COG2319 291 VNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRT---LTGHTGAVRSVAFSPDgkTLASGSDDGTVRLW--DLATGEL 364

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*.
gi 15240616 340 LAMLEGHLGPVKCLtgAF-RDSRkadeasyHIYSGGLDSQVKVWQV 384
Cdd:COG2319 365 LRTLTGHTGAVTSV--AFsPDGR-------TLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
27-384 1.55e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.02  E-value: 1.55e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  27 HQCIATLVCHTaSYISSLTLA--GKRLYTGSNDGVVRLWNANTLETLAEAssngdvitgeRGGGGAVKSLVILAD--KLF 102
Cdd:COG2319 110 GLLLRTLTGHT-GAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTL----------TGHSGAVTSVAFSPDgkLLA 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 103 TAHQDHKIRVWKINDvveedvggkkymhlatmptisdrfAKCLmpknqveirrhkkASWVHHVDAVSGLALSRDGTLLYS 182
Cdd:COG2319 179 SGSDDGTVRLWDLAT------------------------GKLL-------------RTLTGHTGAVRSVAFSPDGKLLAS 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 183 VSWDRTLKIWRTTDFKCLESFTnAHDDAINAVALSENGD-IYTGSSDQRIKVWrknineeNVKKKRkhsLVAILSEHNSG 261
Cdd:COG2319 222 GSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRlLASGSADGTVRLW-------DLATGE---LLRTLTGHSGG 290

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 262 INALALSGtNGSLLHSGGSDGSILVWERDDGGDIVVvgmLRGHTESVLCLAVVSD--ILCSGSADKTVRLWkcSAKDYSC 339
Cdd:COG2319 291 VNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRT---LTGHTGAVRSVAFSPDgkTLASGSDDGTVRLW--DLATGEL 364

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*.
gi 15240616 340 LAMLEGHLGPVKCLtgAF-RDSRkadeasyHIYSGGLDSQVKVWQV 384
Cdd:COG2319 365 LRTLTGHTGAVTSV--AFsPDGR-------TLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 29-383 4.08e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.12  E-value: 4.08e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  29 CIATLVCHTaSYISSLTLA--GKRLYTGSNDGVVRLWNANTletlaeassnGDVITGERGGGGAVKSLVILAD--KLFTA 104
Cdd:cd00200   1 LRRTLKGHT-GGVTCVAFSpdGKLLATGSGDGTIKVWDLET----------GELLRTLKGHTGPVRDVAASADgtYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 105 HQDHKIRVWKINDvveedvggkkymhlatmptisdrfakclmpknqveirRHKKASWVHHVDAVSGLALSRDGTLLYSVS 184
Cdd:cd00200  70 SSDKTIRLWDLET-------------------------------------GECVRTLTGHTSYVSSVAFSPDGRILSSSS 112

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 185 WDRTLKIWRTTDFKCLESFTnAHDDAINAVALSENGD-IYTGSSDQRIKVWRKNINeenvkkkrkhSLVAILSEHNSGIN 263
Cdd:cd00200 113 RDKTIKVWDVETGKCLTTLR-GHTDWVNSVAFSPDGTfVASSSQDGTIKLWDLRTG----------KCVATLTGHTGEVN 181

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 264 ALALSGTNGSLLhSGGSDGSILVWERDDGgdiVVVGMLRGHTESVLCLAV--VSDILCSGSADKTVRLWkcSAKDYSCLA 341
Cdd:cd00200 182 SVAFSPDGEKLL-SSSSDGTIKLWDLSTG---KCLGTLRGHENGVNSVAFspDGYLLASGSEDGTIRVW--DLRTGECVQ 255

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 15240616 342 MLEGHLGPVKCLtgAFRDSRKAdeasyhIYSGGLDSQVKVWQ 383
Cdd:cd00200 256 TLSGHTNSVTSL--AWSPDGKR------LASGSADGTIRIWD 289
PTZ00420 PTZ00420
coronin; Provisional
 280-384 5.31e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.41  E-value: 5.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  280 SDGSILV-WERDDGGDIVVVGM-----------LRGHTESVLCLA---VVSDILCSGSADKTVRLWKCSAKDYSC----- 339
Cdd:PTZ00420  37 SSGFVAVpWEVEGGGLIGAIRLenqmrkppvikLKGHTSSILDLQfnpCFSEILASGSEDLTIRVWEIPHNDESVkeikd 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 15240616  340 -LAMLEGHLGPVKCLTGafrdsrkaDEASYHIY-SGGLDSQVKVWQV 384
Cdd:PTZ00420 117 pQCILKGHKKKISIIDW--------NPMNYYIMcSSGFDSFVNIWDI 155
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 155-192 9.16e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 9.16e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 15240616    155 RHKKASWVHHVDAVSGLALSRDGTLLYSVSWDRTLKIW 192
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
298-330 3.41e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.41e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15240616   298 VGMLRGHTESVLCLAVVSD--ILCSGSADKTVRLW 330
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDgkLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
27-384 1.55e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.02  E-value: 1.55e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  27 HQCIATLVCHTaSYISSLTLA--GKRLYTGSNDGVVRLWNANTLETLAEAssngdvitgeRGGGGAVKSLVILAD--KLF 102
Cdd:COG2319 110 GLLLRTLTGHT-GAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTL----------TGHSGAVTSVAFSPDgkLLA 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 103 TAHQDHKIRVWKINDvveedvggkkymhlatmptisdrfAKCLmpknqveirrhkkASWVHHVDAVSGLALSRDGTLLYS 182
Cdd:COG2319 179 SGSDDGTVRLWDLAT------------------------GKLL-------------RTLTGHTGAVRSVAFSPDGKLLAS 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 183 VSWDRTLKIWRTTDFKCLESFTnAHDDAINAVALSENGD-IYTGSSDQRIKVWrknineeNVKKKRkhsLVAILSEHNSG 261
Cdd:COG2319 222 GSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRlLASGSADGTVRLW-------DLATGE---LLRTLTGHSGG 290

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 262 INALALSGtNGSLLHSGGSDGSILVWERDDGGDIVVvgmLRGHTESVLCLAVVSD--ILCSGSADKTVRLWkcSAKDYSC 339
Cdd:COG2319 291 VNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRT---LTGHTGAVRSVAFSPDgkTLASGSDDGTVRLW--DLATGEL 364

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*.
gi 15240616 340 LAMLEGHLGPVKCLtgAF-RDSRkadeasyHIYSGGLDSQVKVWQV 384
Cdd:COG2319 365 LRTLTGHTGAVTSV--AFsPDGR-------TLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 29-383 4.08e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.12  E-value: 4.08e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  29 CIATLVCHTaSYISSLTLA--GKRLYTGSNDGVVRLWNANTletlaeassnGDVITGERGGGGAVKSLVILAD--KLFTA 104
Cdd:cd00200   1 LRRTLKGHT-GGVTCVAFSpdGKLLATGSGDGTIKVWDLET----------GELLRTLKGHTGPVRDVAASADgtYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 105 HQDHKIRVWKINDvveedvggkkymhlatmptisdrfakclmpknqveirRHKKASWVHHVDAVSGLALSRDGTLLYSVS 184
Cdd:cd00200  70 SSDKTIRLWDLET-------------------------------------GECVRTLTGHTSYVSSVAFSPDGRILSSSS 112

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 185 WDRTLKIWRTTDFKCLESFTnAHDDAINAVALSENGD-IYTGSSDQRIKVWRKNINeenvkkkrkhSLVAILSEHNSGIN 263
Cdd:cd00200 113 RDKTIKVWDVETGKCLTTLR-GHTDWVNSVAFSPDGTfVASSSQDGTIKLWDLRTG----------KCVATLTGHTGEVN 181

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 264 ALALSGTNGSLLhSGGSDGSILVWERDDGgdiVVVGMLRGHTESVLCLAV--VSDILCSGSADKTVRLWkcSAKDYSCLA 341
Cdd:cd00200 182 SVAFSPDGEKLL-SSSSDGTIKLWDLSTG---KCLGTLRGHENGVNSVAFspDGYLLASGSEDGTIRVW--DLRTGECVQ 255

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 15240616 342 MLEGHLGPVKCLtgAFRDSRKAdeasyhIYSGGLDSQVKVWQ 383
Cdd:cd00200 256 TLSGHTNSVTSL--AWSPDGKR------LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
28-384 6.80e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.39  E-value: 6.80e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  28 QCIATLVCHTASYIS-SLTLAGKRLYTGSNDGVVRLWNANTletlaeassnGDVITGERGGGGAVKSLVILAD--KLFTA 104
Cdd:COG2319  69 ALLATLLGHTAAVLSvAFSPDGRLLASASADGTVRLWDLAT----------GLLLRTLTGHTGAVRSVAFSPDgkTLASG 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 105 HQDHKIRVWKINDvveedvggkkymhlatmptisdrfAKCLmpknqveirrhkkASWVHHVDAVSGLALSRDGTLLYSVS 184
Cdd:COG2319 139 SADGTVRLWDLAT------------------------GKLL-------------RTLTGHSGAVTSVAFSPDGKLLASGS 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 185 WDRTLKIWRTTDFKCLESFTnAHDDAINAVALSENGD-IYTGSSDQRIKVWrknineeNVKKKRkhsLVAILSEHNSGIN 263
Cdd:COG2319 182 DDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKlLASGSADGTVRLW-------DLATGK---LLRTLTGHSGSVR 250

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 264 ALALSGtNGSLLHSGGSDGSILVWERDDGgdiVVVGMLRGHTESVLCLAVVSD--ILCSGSADKTVRLWkcSAKDYSCLA 341
Cdd:COG2319 251 SVAFSP-DGRLLASGSADGTVRLWDLATG---ELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLW--DLATGKLLR 324

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 15240616 342 MLEGHLGPVKCLtgAF-RDSRkadeasyHIYSGGLDSQVKVWQV 384
Cdd:COG2319 325 TLTGHTGAVRSV--AFsPDGK-------TLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 28-331 3.80e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.01  E-value: 3.80e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  28 QCIATLVCHTASYISSLTLA-GKRLYTGSNDGVVRLWNANTLETLAEassngdvITGERgggGAVKSLVILADK--LFTA 104
Cdd:cd00200  42 ELLRTLKGHTGPVRDVAASAdGTYLASGSSDKTIRLWDLETGECVRT-------LTGHT---SYVSSVAFSPDGriLSSS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 105 HQDHKIRVWKINDvveedvggkkymhlatmptisdrfAKCLMpknqveirrhkkaSWVHHVDAVSGLALSRDGTLLYSVS 184
Cdd:cd00200 112 SRDKTIKVWDVET------------------------GKCLT-------------TLRGHTDWVNSVAFSPDGTFVASSS 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 185 WDRTLKIWRTTDFKCLESFTnAHDDAINAVALSENG-DIYTGSSDQRIKVWRknineenvkkKRKHSLVAILSEHNSGIN 263
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGeKLLSSSSDGTIKLWD----------LSTGKCLGTLRGHENGVN 223

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 264 ALALSgTNGSLLHSGGSDGSILVWERDDGgdiVVVGMLRGHTESVLCLAVVSD--ILCSGSADKTVRLWK 331
Cdd:cd00200 224 SVAFS-PDGYLLASGSEDGTIRVWDLRTG---ECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
28-291 8.44e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.65  E-value: 8.44e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  28 QCIATLVCHTASyISSLTLA--GKRLYTGSNDGVVRLWNANTletlaeassnGDVITGERGGGGAVKSLVILAD--KLFT 103
Cdd:COG2319 195 KLLRTLTGHTGA-VRSVAFSpdGKLLASGSADGTVRLWDLAT----------GKLLRTLTGHSGSVRSVAFSPDgrLLAS 263

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 104 AHQDHKIRVWkindvveeDVGGKKYMHLATmptisdrfakclmpknqveirrhkkaswvHHVDAVSGLALSRDGTLLYSV 183
Cdd:COG2319 264 GSADGTVRLW--------DLATGELLRTLT-----------------------------GHSGGVNSVAFSPDGKLLASG 306

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 184 SWDRTLKIWRTTDFKCLESFTnAHDDAINAVALSENGD-IYTGSSDQRIKVWrknineeNVKKKRkhsLVAILSEHNSGI 262
Cdd:COG2319 307 SDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKtLASGSDDGTVRLW-------DLATGE---LLRTLTGHTGAV 375

                       250       260
                ....*....|....*....|....*....
gi 15240616 263 NALALSGtNGSLLHSGGSDGSILVWERDD 291
Cdd:COG2319 376 TSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-384 9.99e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.29  E-value: 9.99e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 164 HVDAVSGLALSRDGTLLYSVSWDRTLKIWRTTDFKCLESFTnAHDDAINAVALSENGDI-YTGSSDQRIKVWrknineeN 242
Cdd:cd00200  50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT-GHTSYVSSVAFSPDGRIlSSSSRDKTIKVW-------D 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 243 VKKKRkhsLVAILSEHNSGINALALSGTNGSLLhSGGSDGSILVWerdDGGDIVVVGMLRGHTESVLCLAVVSD--ILCS 320
Cdd:cd00200 122 VETGK---CLTTLRGHTDWVNSVAFSPDGTFVA-SSSQDGTIKLW---DLRTGKCVATLTGHTGEVNSVAFSPDgeKLLS 194

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15240616 321 GSADKTVRLWKCSAKDysCLAMLEGHLGPVKCLtgAFrdsrkaDEASYHIYSGGLDSQVKVWQV 384
Cdd:cd00200 195 SSSDGTIKLWDLSTGK--CLGTLRGHENGVNSV--AF------SPDGYLLASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
153-384 3.42e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 3.42e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 153 IRRHKKASWVHHVDAVSGLALSRDGTLLYSVSWDRTLKIWRTTDFKCLESFTnAHDDAINAVALSENGD-IYTGSSDQRI 231
Cdd:COG2319  24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL-GHTAAVLSVAFSPDGRlLASASADGTV 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 232 KVWRKNineenvkkkrKHSLVAILSEHNSGINALALSgTNGSLLHSGGSDGSILVWERDDGGDIVVvgmLRGHTESVLCL 311
Cdd:COG2319 103 RLWDLA----------TGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLATGKLLRT---LTGHSGAVTSV 168

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15240616 312 AVVSD--ILCSGSADKTVRLWkcSAKDYSCLAMLEGHLGPVKCLtgAF-RDSRkadeasyHIYSGGLDSQVKVWQV 384
Cdd:COG2319 169 AFSPDgkLLASGSDDGTVRLW--DLATGKLLRTLTGHTGAVRSV--AFsPDGK-------LLASGSADGTVRLWDL 233
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-235 5.89e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 5.89e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  12 DFSQEDH-LTSSSQ---------PLHQCIATLVCHTASYIS-SLTLAGKRLYTGSNDGVVRLWNANTLETLAeassngdV 80
Cdd:cd00200 100 AFSPDGRiLSSSSRdktikvwdvETGKCLTTLRGHTDWVNSvAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-------T 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  81 ITGERGGggaVKSLVILAD--KLFTAHQDHKIRVWKIndvveedvggkkymhlatmptisdRFAKCLMpknqvEIRRHKk 158
Cdd:cd00200 173 LTGHTGE---VNSVAFSPDgeKLLSSSSDGTIKLWDL------------------------STGKCLG-----TLRGHE- 219

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15240616 159 aswvhhvDAVSGLALSRDGTLLYSVSWDRTLKIWRTTDFKCLESFTnAHDDAINAVALSENG-DIYTGSSDQRIKVWR 235
Cdd:cd00200 220 -------NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGkRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 251-384 1.22e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 1.22e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616 251 LVAILSEHNSGINALALSgTNGSLLHSGGSDGSILVWERDDGGDIVVvgmLRGHTESVLCLAVVSDI--LCSGSADKTVR 328
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRT---LKGHTGPVRDVAASADGtyLASGSSDKTIR 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15240616 329 LWkcSAKDYSCLAMLEGHLGPVKCLtgAFRDSRKAdeasyhIYSGGLDSQVKVWQV 384
Cdd:cd00200  77 LW--DLETGECVRTLTGHTSYVSSV--AFSPDGRI------LSSSSRDKTIKVWDV 122
PTZ00420 PTZ00420
coronin; Provisional
 280-384 5.31e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.41  E-value: 5.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  280 SDGSILV-WERDDGGDIVVVGM-----------LRGHTESVLCLA---VVSDILCSGSADKTVRLWKCSAKDYSC----- 339
Cdd:PTZ00420  37 SSGFVAVpWEVEGGGLIGAIRLenqmrkppvikLKGHTSSILDLQfnpCFSEILASGSEDLTIRVWEIPHNDESVkeikd 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 15240616  340 -LAMLEGHLGPVKCLTGafrdsrkaDEASYHIY-SGGLDSQVKVWQV 384
Cdd:PTZ00420 117 pQCILKGHKKKISIIDW--------NPMNYYIMcSSGFDSFVNIWDI 155
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 157-384 1.10e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  157 KKASWVHHVDAVSGLALSRDGTLLYSVSWDRTLKIwrttdFKCLESFTNAHDDAINAVALSENGDIYTGSSDQRIKVWRK 236
Cdd:PLN00181 475 KQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKI-----FECESIIKDGRDIHYPVVELASRSKLSGICWNSYIKSQVA 549

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  237 NINEENVKK---KRKHSLVAILSEHNSGINALALSGTNGSLLHSGGSDGSILVWERDDGgdiVVVGMLRGHTeSVLCLAV 313
Cdd:PLN00181 550 SSNFEGVVQvwdVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQG---VSIGTIKTKA-NICCVQF 625

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15240616  314 VSDI---LCSGSADKTVRLWKCSAKDYSCLAMLeGHLGPVKCLTgaFRDSRKadeasyhIYSGGLDSQVKVWQV 384
Cdd:PLN00181 626 PSESgrsLAFGSADHKVYYYDLRNPKLPLCTMI-GHSKTVSYVR--FVDSST-------LVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 155-192 9.16e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 9.16e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 15240616    155 RHKKASWVHHVDAVSGLALSRDGTLLYSVSWDRTLKIW 192
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 297-331 1.17e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 15240616    297 VVGMLRGHTESVLCLAVVSD--ILCSGSADKTVRLWK 331
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
298-330 3.41e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.41e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15240616   298 VGMLRGHTESVLCLAVVSD--ILCSGSADKTVRLW 330
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDgkLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
159-192 3.41e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.41e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 15240616   159 ASWVHHVDAVSGLALSRDGTLLYSVSWDRTLKIW 192
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 248-288 7.30e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 7.30e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15240616    248 KHSLVAILSEHNSGINALALSGtNGSLLHSGGSDGSILVWE 288
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 196-234 1.44e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.44e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15240616    196 DFKCLESFTnAHDDAINAVALSENGD-IYTGSSDQRIKVW 234
Cdd:smart00320   1 SGELLKTLK-GHTGPVTSVAFSPDGKyLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
250-288 2.49e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15240616   250 SLVAILSEHNSGINALALSgTNGSLLHSGGSDGSILVWE 288
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
197-234 2.86e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 2.86e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15240616   197 FKCLESFTnAHDDAINAVALSENGD-IYTGSSDQRIKVW 234
Cdd:pfam00400   1 GKLLKTLE-GHTGSVTSLAFSPDGKlLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 218-329 3.92e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.11  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240616  218 ENGDIYTGSSDQRIKVWrkNINEENVKKKRKHSLVAiLSEHNSGINALALSGTNGSLLHSGGSDGSILVWERDDGgdiVV 297
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGW--GIPEEGLTQNISDPIVH-LQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERG---KA 160

                         90       100       110
                 ....*....|....*....|....*....|....
gi 15240616  298 VGMLRGHTESVLCLA--VVSDILCSGSADKTVRL 329
Cdd:PTZ00421 161 VEVIKCHSDQITSLEwnLDGSLLCTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 28-64 4.94e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 4.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 15240616     28 QCIATLVCHTaSYISSLTLA--GKRLYTGSNDGVVRLWN 64
Cdd:smart00320   3 ELLKTLKGHT-GPVTSVAFSpdGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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