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Conserved domains on  [gi|15237303|ref|NP_200104|]
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plastidic pyruvate kinase beta subunit 1 [Arabidopsis thaliana]

Protein Classification

PLN02623 family protein( domain architecture ID 11477002)

PLN02623 family protein

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02623 PLN02623
pyruvate kinase
1-579 0e+00

pyruvate kinase


:

Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 1102.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303    1 MAQVVATRSIQGSMLSPNGGSVSTRsekLLKPASFAVKVLGNEAKRSGRVSVRSRRVVDTTVRSARVETEVIPVSPED-- 78
Cdd:PLN02623   2 AAQVVATRSIDSSILSSSSGSVSLD---LLSPLSFASKVLGSEARARRRVAVRRRAVTAASLRSKSQETEVIPVSPEDgg 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   79 VPNREEQLERLLEMQQFGDTSVGMWSKPTVRRKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLV 158
Cdd:PLN02623  79 ANFVEDNEEVLLEIQQLGETAVGMWSKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  159 KEYNAQTKDNTIAIMLDTKGPEVRSGDLPQPIMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSF 238
Cdd:PLN02623 159 KEYNAQSKDNVIAIMLDTKGPEVRSGDLPQPIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSL 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  239 MVKSKTKDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGA 318
Cdd:PLN02623 239 AVKSKTSDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNA 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  319 DIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRA 398
Cdd:PLN02623 319 DIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRA 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  399 EVSDIAIAVREGADAVMLSGETAHGKFPLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMSEMFAYHATMMSNTLGT 478
Cdd:PLN02623 399 EVSDIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEMFAFHATMMANTLGT 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  479 STVVFTRTGFMAILLSHYRPSGTIYAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIV 558
Cdd:PLN02623 479 SIIVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALV 558
                        570       580
                 ....*....|....*....|.
gi 15237303  559 QSGTQPIWRSQSTHNIQVRKV 579
Cdd:PLN02623 559 QSGRQPIWRSESTHHIQVRKV 579
 
Name Accession Description Interval E-value
PLN02623 PLN02623
pyruvate kinase
1-579 0e+00

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 1102.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303    1 MAQVVATRSIQGSMLSPNGGSVSTRsekLLKPASFAVKVLGNEAKRSGRVSVRSRRVVDTTVRSARVETEVIPVSPED-- 78
Cdd:PLN02623   2 AAQVVATRSIDSSILSSSSGSVSLD---LLSPLSFASKVLGSEARARRRVAVRRRAVTAASLRSKSQETEVIPVSPEDgg 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   79 VPNREEQLERLLEMQQFGDTSVGMWSKPTVRRKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLV 158
Cdd:PLN02623  79 ANFVEDNEEVLLEIQQLGETAVGMWSKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  159 KEYNAQTKDNTIAIMLDTKGPEVRSGDLPQPIMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSF 238
Cdd:PLN02623 159 KEYNAQSKDNVIAIMLDTKGPEVRSGDLPQPIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSL 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  239 MVKSKTKDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGA 318
Cdd:PLN02623 239 AVKSKTSDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNA 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  319 DIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRA 398
Cdd:PLN02623 319 DIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRA 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  399 EVSDIAIAVREGADAVMLSGETAHGKFPLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMSEMFAYHATMMSNTLGT 478
Cdd:PLN02623 399 EVSDIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEMFAFHATMMANTLGT 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  479 STVVFTRTGFMAILLSHYRPSGTIYAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIV 558
Cdd:PLN02623 479 SIIVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALV 558
                        570       580
                 ....*....|....*....|.
gi 15237303  559 QSGTQPIWRSQSTHNIQVRKV 579
Cdd:PLN02623 559 QSGRQPIWRSESTHHIQVRKV 579
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
110-579 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 602.02  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKDNtIAIMLDTKGPEVRSGDLPQ- 188
Cdd:COG0469   3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRP-VAILLDLQGPKIRTGKFKEg 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 189 PIMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNVRG 268
Cdd:COG0469  82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 269 KSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITASDGAMVA 348
Cdd:COG0469 162 VGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMVA 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 349 RGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLK 428
Cdd:COG0469 242 RGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVE 321
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 429 AAGVMHTVALRTEATITSGEMPPNLGQAFKNHMSEMFAYHATMMSNTLGTST-VVFTRTGFMAILLSHYRPSGTIYAFTN 507
Cdd:COG0469 322 AVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAiVAFTESGSTARRISRYRPKVPILALTP 401
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15237303 508 EKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIVqSGTqPIWRSQSTHNIQVRKV 579
Cdd:COG0469 402 NERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVIT-AGV-PVGVPGTTNTLKVHRV 471
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
110-576 4.93e-173

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 498.73  E-value: 4.93e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYnAQTKDNTIAIMLDTKGPEVRSGDLPQ- 188
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREA-AEKLGRPVAILLDTKGPEIRTGEIKGg 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   189 PIMLDPGQEFTFTIE--RGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNV 266
Cdd:TIGR01064  80 EVKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGA-DIHVIVKIESADSIPNLHSIITASDGA 345
Cdd:TIGR01064 160 PGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAkDVKIIAKIENQEGVDNIDEIAEASDGI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   346 MVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
Cdd:TIGR01064 240 MVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKY 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   426 PLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMS--EMFAYHATMMSNTLGTST-VVFTRTGFMAILLSHYRPSGTI 502
Cdd:TIGR01064 320 PVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTitEAIALSAVEAAEKLDAKAiVVLTESGRTARLLSKYRPNAPI 399
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15237303   503 YAFTNEKKIQQRLALYQGVCPIYM-EFTDDAEETFANALATLLKQGMVKKGEEIAIVQSGTQPIwrSQSTHNIQV 576
Cdd:TIGR01064 400 IAVTPNERVARQLALYWGVFPFLVdEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGG--EGGTNTIRV 472
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
110-577 5.79e-152

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 445.22  E-value: 5.79e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKdNTIAIMLDTKGPEVRSGDLP-- 187
Cdd:cd00288   2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG-GPVAIALDTKGPEIRTGLFKgg 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 188 QPIMLDPGQEFTFTIE--RGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDS-VKCEVVDGGELKSRRHL 264
Cdd:cd00288  81 KDISLKAGDKFLVTTDpaAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 265 NVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITASDG 344
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 345 AMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGK 424
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 425 FPLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMS--EMFAYHATMMSNTLGTST-VVFTRTGFMAILLSHYRPSGT 501
Cdd:cd00288 321 YPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSttEAVAMSAVRAAFELGAKAiVVLTTSGRTARLVSKYRPNAP 400
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 502 IYAFTNEKKIQQRLALYQGVCPIYME-----FTDDAEETFANALATLLKQGMVKKGEEIAIVQSgtqpiWRSQSTHNIQV 576
Cdd:cd00288 401 IIAVTRNEQTARQLHLYRGVYPVLFEepkpgWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQG-----WPVGSGSTNTM 475

                .
gi 15237303 577 R 577
Cdd:cd00288 476 R 476
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
110-444 4.86e-130

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 384.41  E-value: 4.86e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKdNTIAIMLDTKGPEVRSGDL--- 186
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTG-GTVAIALDTKGPEIRTGNTkdg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   187 PQPIMLDPGQEFTFTIE---RGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDS-VKCEVVDGGELKSRR 262
Cdd:pfam00224  81 KKDIELKAGDEMIVSTDakyKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   263 HLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITAS 342
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   343 DGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAH 422
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
                         330       340
                  ....*....|....*....|..
gi 15237303   423 GKFPLKAAGVMHTVALRTEATI 444
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKAL 342
 
Name Accession Description Interval E-value
PLN02623 PLN02623
pyruvate kinase
1-579 0e+00

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 1102.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303    1 MAQVVATRSIQGSMLSPNGGSVSTRsekLLKPASFAVKVLGNEAKRSGRVSVRSRRVVDTTVRSARVETEVIPVSPED-- 78
Cdd:PLN02623   2 AAQVVATRSIDSSILSSSSGSVSLD---LLSPLSFASKVLGSEARARRRVAVRRRAVTAASLRSKSQETEVIPVSPEDgg 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   79 VPNREEQLERLLEMQQFGDTSVGMWSKPTVRRKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLV 158
Cdd:PLN02623  79 ANFVEDNEEVLLEIQQLGETAVGMWSKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  159 KEYNAQTKDNTIAIMLDTKGPEVRSGDLPQPIMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSF 238
Cdd:PLN02623 159 KEYNAQSKDNVIAIMLDTKGPEVRSGDLPQPIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSL 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  239 MVKSKTKDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGA 318
Cdd:PLN02623 239 AVKSKTSDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNA 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  319 DIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRA 398
Cdd:PLN02623 319 DIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRA 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  399 EVSDIAIAVREGADAVMLSGETAHGKFPLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMSEMFAYHATMMSNTLGT 478
Cdd:PLN02623 399 EVSDIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEMFAFHATMMANTLGT 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  479 STVVFTRTGFMAILLSHYRPSGTIYAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIV 558
Cdd:PLN02623 479 SIIVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALV 558
                        570       580
                 ....*....|....*....|.
gi 15237303  559 QSGTQPIWRSQSTHNIQVRKV 579
Cdd:PLN02623 559 QSGRQPIWRSESTHHIQVRKV 579
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
110-579 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 602.02  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKDNtIAIMLDTKGPEVRSGDLPQ- 188
Cdd:COG0469   3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRP-VAILLDLQGPKIRTGKFKEg 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 189 PIMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNVRG 268
Cdd:COG0469  82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 269 KSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITASDGAMVA 348
Cdd:COG0469 162 VGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMVA 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 349 RGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLK 428
Cdd:COG0469 242 RGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVE 321
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 429 AAGVMHTVALRTEATITSGEMPPNLGQAFKNHMSEMFAYHATMMSNTLGTST-VVFTRTGFMAILLSHYRPSGTIYAFTN 507
Cdd:COG0469 322 AVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAiVAFTESGSTARRISRYRPKVPILALTP 401
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15237303 508 EKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIVqSGTqPIWRSQSTHNIQVRKV 579
Cdd:COG0469 402 NERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVIT-AGV-PVGVPGTTNTLKVHRV 471
PRK05826 PRK05826
pyruvate kinase; Provisional
110-561 1.10e-176

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 507.77  E-value: 1.10e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYnAQTKDNTIAIMLDTKGPEVRSGDLPQ- 188
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREI-AAKLGRPVAILLDLKGPKIRVGKFKEg 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  189 PIMLDPGQEFTFTIER-GVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNVR 267
Cdd:PRK05826  83 KITLKTGDKFTLDTDQkEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  268 GKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGA-DIHVIVKIESADSIPNLHSIITASDGAM 346
Cdd:PRK05826 163 GGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAVDNIDEIIEASDGIM 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  347 VARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFP 426
Cdd:PRK05826 243 VARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYP 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  427 LKAAGVMHTVALRTEATITSGEMPPNLGQAFKNhMSEMFAYHATMMSNTLG--TSTVVFTRTGFMAILLSHYRPSGTIYA 504
Cdd:PRK05826 323 VEAVEAMARICKGAEKEFSINLSKHRLDRQFDR-IDEAIAMSAMYAANHLKgvKAIVALTESGRTARLISRFRPGAPIFA 401
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 15237303  505 FTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIVQSG 561
Cdd:PRK05826 402 VTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGD 458
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
110-576 4.93e-173

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 498.73  E-value: 4.93e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYnAQTKDNTIAIMLDTKGPEVRSGDLPQ- 188
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREA-AEKLGRPVAILLDTKGPEIRTGEIKGg 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   189 PIMLDPGQEFTFTIE--RGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNV 266
Cdd:TIGR01064  80 EVKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGA-DIHVIVKIESADSIPNLHSIITASDGA 345
Cdd:TIGR01064 160 PGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAkDVKIIAKIENQEGVDNIDEIAEASDGI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   346 MVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
Cdd:TIGR01064 240 MVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKY 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   426 PLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMS--EMFAYHATMMSNTLGTST-VVFTRTGFMAILLSHYRPSGTI 502
Cdd:TIGR01064 320 PVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTitEAIALSAVEAAEKLDAKAiVVLTESGRTARLLSKYRPNAPI 399
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15237303   503 YAFTNEKKIQQRLALYQGVCPIYM-EFTDDAEETFANALATLLKQGMVKKGEEIAIVQSGTQPIwrSQSTHNIQV 576
Cdd:TIGR01064 400 IAVTPNERVARQLALYWGVFPFLVdEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGG--EGGTNTIRV 472
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
110-579 3.75e-159

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 464.60  E-value: 3.75e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQtKDNTIAIMLDTKGPEVRSGDL--P 187
Cdd:PLN02762  25 RRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEE-KGFAVAVMMDTEGSEIHMGDLggA 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  188 QPIMLDPGQEFTFTIER-GVSTPSC-VSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLN 265
Cdd:PLN02762 104 SSAKAEDGEEWTFTVRKfDGSRPEFtIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLLPRANLT 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  266 -------VRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQN--SGADIHVIVKIESADSIPNLH 336
Cdd:PLN02762 184 fwrdgslVRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAArsRDSDIGVIAKIESLDSLKNLE 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  337 SIITASDGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVML 416
Cdd:PLN02762 264 EIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALML 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  417 SGETAHGKFPLKAAGVMHTVALRTE----ATITSGEMP-PNLGQAFKNHMSEMFAYHATMMSNTLGTSTV-VFTRTGFMA 490
Cdd:PLN02762 344 SGESAMGLYPEKALSVLRSVSLRMElwsrEEKRHEALElPQLSSSLSDRISEEICNSAAKMANNLGVDAIfVYTKHGHMA 423
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  491 ILLSHYRPSGTIYAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIVqSGTQPIWRSQS 570
Cdd:PLN02762 424 SLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGDLVIAV-SDLTPSSMLQS 502

                 ....*....
gi 15237303  571 thnIQVRKV 579
Cdd:PLN02762 503 ---IQVRNV 508
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
110-577 5.79e-152

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 445.22  E-value: 5.79e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKdNTIAIMLDTKGPEVRSGDLP-- 187
Cdd:cd00288   2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG-GPVAIALDTKGPEIRTGLFKgg 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 188 QPIMLDPGQEFTFTIE--RGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDS-VKCEVVDGGELKSRRHL 264
Cdd:cd00288  81 KDISLKAGDKFLVTTDpaAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 265 NVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITASDG 344
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 345 AMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGK 424
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 425 FPLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMS--EMFAYHATMMSNTLGTST-VVFTRTGFMAILLSHYRPSGT 501
Cdd:cd00288 321 YPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSttEAVAMSAVRAAFELGAKAiVVLTTSGRTARLVSKYRPNAP 400
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 502 IYAFTNEKKIQQRLALYQGVCPIYME-----FTDDAEETFANALATLLKQGMVKKGEEIAIVQSgtqpiWRSQSTHNIQV 576
Cdd:cd00288 401 IIAVTRNEQTARQLHLYRGVYPVLFEepkpgWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQG-----WPVGSGSTNTM 475

                .
gi 15237303 577 R 577
Cdd:cd00288 476 R 476
PRK09206 PRK09206
pyruvate kinase PykF;
110-562 7.10e-131

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 390.95  E-value: 7.10e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTkDNTIAIMLDTKGPEVRSGDLP-- 187
Cdd:PRK09206   2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKT-GKKAAILLDTKGPEIRTMKLEgg 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  188 QPIMLDPGQEFTFTIERGV-STPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNV 266
Cdd:PRK09206  81 NDVSLKAGQTFTFTTDKSVvGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYL-QNSGADIHVIVKIESADSIPNLHSIITASDGA 345
Cdd:PRK09206 161 PGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLkAHGGENIQIISKIENQEGLNNFDEILEASDGI 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  346 MVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
Cdd:PRK09206 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  426 PLKAAGVMHTVALRTEATitsgeMPPNLGQAF---KNHMSEMFAYHATMMSNTLGTS-TVVFTRTGFMAILLSHYRPSGT 501
Cdd:PRK09206 321 PLEAVSIMATICERTDRV-----MNSRLESNNdnrKLRITEAVCRGAVETAEKLDAPlIVVATQGGKSARSVRKYFPDAT 395
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15237303  502 IYAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEI-----AIVQSGT 562
Cdd:PRK09206 396 ILALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVvmvsgALVPSGT 461
PRK06354 PRK06354
pyruvate kinase; Provisional
110-576 2.08e-130

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 393.91  E-value: 2.08e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYnAQTKDNTIAIMLDTKGPEVRSGDLP-Q 188
Cdd:PRK06354   8 RRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREA-SKKLGKTVGILQDLQGPKIRLGRFEdG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  189 PIMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKS--KTKDSVKCEVVDGGELKSRRHLNV 266
Cdd:PRK06354  87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEvdKADGELHCKVLVGGVLSNKKGVNF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYL-QNSGADIHVIVKIESADSIPNLHSIITASDGA 345
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIeEHNGKHIPIIAKIEKQEAIDNIDAILELCDGL 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  346 MVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  426 PLKAAGVMHTVALRTEATITSGEM---PPNLGQAFKNHMSEMFAYHATmmsnTLGTSTVV-FTRTGFMAILLSHYRPSGT 501
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRDIlskRPEFTTTITNAISQAVSHIAL----QLDAAAIVtLTKSGATARNVSKYRPKTP 402
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15237303  502 IYAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEeiAIVQSGTQPIWRSQSTHNIQV 576
Cdd:PRK06354 403 ILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGD--LVVITAGTLVGESGSTDLMKV 475
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
110-444 4.86e-130

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 384.41  E-value: 4.86e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKdNTIAIMLDTKGPEVRSGDL--- 186
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTG-GTVAIALDTKGPEIRTGNTkdg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   187 PQPIMLDPGQEFTFTIE---RGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDS-VKCEVVDGGELKSRR 262
Cdd:pfam00224  81 KKDIELKAGDEMIVSTDakyKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   263 HLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITAS 342
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   343 DGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAH 422
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
                         330       340
                  ....*....|....*....|..
gi 15237303   423 GKFPLKAAGVMHTVALRTEATI 444
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKAL 342
PRK06247 PRK06247
pyruvate kinase; Provisional
110-558 6.81e-121

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 365.40  E-value: 6.81e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTkDNTIAIMLDTKGPEVRSGDLPQ- 188
Cdd:PRK06247   5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDET-GRPIGILADLQGPKLRLGRFADg 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  189 PIMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNVRG 268
Cdd:PRK06247  84 KVQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLPG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  269 KSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYlqnSGADIHVIVKIESADSIPNLHSIITASDGAMVA 348
Cdd:PRK06247 164 TVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKI---IGGRVPVMAKIEKPQAIDRLEAIVEASDAIMVA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  349 RGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLK 428
Cdd:PRK06247 241 RGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVE 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  429 AAGVMHTVALRTEA-----TITSGEMPPNLGQAfknhmSEMFAYHATMMSNTLGTSTVV-FTRTGFMAILLSHYRPSGTI 502
Cdd:PRK06247 321 AVRTMARIIRQVERdptypPLIHAQRPQPEATK-----RDAISYAARDIAERLDLAALVaYTSSGDTALRAARERPPLPI 395
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15237303  503 YAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIV 558
Cdd:PRK06247 396 LALTPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIV 451
PLN02461 PLN02461
Probable pyruvate kinase
109-555 6.35e-105

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 325.39  E-value: 6.35e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  109 RRKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKeynaQTKDNT---IAIMLDTKGPEVRSGD 185
Cdd:PLN02461  20 RPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLR----QAMANTgilCAVMLDTKGPEIRTGF 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  186 LP--QPIMLDPGQEFTFTIERGVS-TPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKS--KTKDSVKCEVVDGGELKS 260
Cdd:PLN02461  96 LKdgKPVQLKQGQEITITTDYSIKgDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLScdVEAGTVRCRCENSAMLGE 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  261 RRHLNVRGKSATLPSITEKDWEDI-KFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSII 339
Cdd:PLN02461 176 RKNVNLPGVVVDLPTLTEKDKEDIlQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDIL 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  340 TASDGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGE 419
Cdd:PLN02461 256 AESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGE 335
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  420 TAHGKFPLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMS--EMFAYHATMMSNTLGTS-TVVFTRTGFMAILLSHY 496
Cdd:PLN02461 336 TAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSplESLASSAVRTANKVKASlIVVLTRGGTTARLVAKY 415
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15237303  497 RPSGTI--------------YAFTNEKKIQQRLaLYQGVCPIYME------FTDDAEETFANALATLLKQGMVKKGEEI 555
Cdd:PLN02461 416 RPAVPIlsvvvpeittdsfdWSCSDEAPARHSL-IYRGLIPVLAEgsakatDSESTEEILEAAIEHAKKKGLCKPGDSV 493
PTZ00066 PTZ00066
pyruvate kinase; Provisional
110-558 7.19e-104

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 322.87  E-value: 7.19e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKDNTIAIMLDTKGPEVRSGDL--P 187
Cdd:PTZ00066  38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARPNANLGILLDTKGPEIRTGFLknH 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  188 QPIMLDPGQEFTFTIERG-VSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNV 266
Cdd:PTZ00066 118 KPITLKEGQTLKITTDYTfLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNL 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  267 RGKSATLPSITEKDWEDI-KFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITASDGA 345
Cdd:PTZ00066 198 PGVKVELPVIGEKDKNDIlNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGI 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  346 MVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
Cdd:PTZ00066 278 MVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKF 357
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  426 PLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMS--EMFAYHATMMSNTLGTS-TVVFTRTGFMAILLSHYRPSGTI 502
Cdd:PTZ00066 358 PVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSvqEAVARSAVETAEDINAKlIIALTETGNTARLISKYRPSCTI 437
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15237303  503 YAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIV 558
Cdd:PTZ00066 438 LALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAV 493
PTZ00300 PTZ00300
pyruvate kinase; Provisional
136-560 3.23e-86

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 275.01  E-value: 3.23e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  136 MNVARMNMSHGDHASHKKVIDLVKEYNAQTKDNtIAIMLDTKGPEVRSGDLPQ-PIMLDPGQEFTFTIERGVS---TPSC 211
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVN-IAIALDTKGPEIRTGLFVGgEAVMERGATCYVTTDPAFAdkgTKDK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  212 VSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKD-SVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVEN 290
Cdd:PTZ00300  80 FYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEqTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  291 KVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPILQEEIIN 370
Cdd:PTZ00300 160 GVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILIS 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  371 LCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLKAAGVMHTVALRTEATITSGEMP 450
Cdd:PTZ00300 240 KCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYVFF 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  451 PNLGQAFKNHMSEMFAYHATMMSN---TLGTSTVVFTRTGFMAILLSHYRPSGTIYAFTNEKKIQQRLALYQGVCPIYME 527
Cdd:PTZ00300 320 NSIKKLQPIPMSAEEAVCSSAVNSvyeTKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFFD 399
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 15237303  528 -----FTDDAEETFANALATLLKQGMVKKGEEIAIVQS 560
Cdd:PTZ00300 400 aerlgHDEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHA 437
PRK06739 PRK06739
pyruvate kinase; Validated
115-437 1.64e-84

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 267.20  E-value: 1.64e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  115 VCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKeynaqTKDNTIAIMLDTKGPEVRSGDLP-QPIMLD 193
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVK-----SLDDSIKILGDVQGPKIRLGEIKgEQITLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  194 PGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNVRGKSATL 273
Cdd:PRK06739  81 AGDSFILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  274 PSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADI-HVIVKIESADSIPNLHSIITASDGAMVARGDL 352
Cdd:PRK06739 161 PAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKEADGIMIARGDL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  353 GAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLKAAGV 432
Cdd:PRK06739 241 GVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVST 320

                 ....*
gi 15237303  433 MHTVA 437
Cdd:PRK06739 321 LRLVS 325
PLN02765 PLN02765
pyruvate kinase
112-559 2.10e-62

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 214.53  E-value: 2.10e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  112 TKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKdNTIAIMLDTKGPEVRSGDLP-QPI 190
Cdd:PLN02765  30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTK-KLCAVMLDTVGPELQVINKTeKPI 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  191 MLDPGQEFTFTIERGVSTPSCV-SVNYDDFVNDVEAGDMLLVdgGMMSFmVKSKTKdSVKCEV--VDGGEL--------- 258
Cdd:PLN02765 109 SLKAGNTVTLTPDQSKEASSEVlPINFPGLAKAVKPGDTIFV--GQYLF-TGSETT-SVWLEVdeVKGDDVvctvknsat 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  259 --KSRRHLNVRGKSATLPSITEKDWEDIK-FGVENKVDFYAVSFVKDAQVVHELKKYLQNSG-ADIHVIVKIESADSIPN 334
Cdd:PLN02765 185 laGSLFTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIENVEGLTH 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  335 LHSIITASDGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVaTNMLESMIVHPTPTRAEVSDIAIAVREGADAV 414
Cdd:PLN02765 265 FDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAI 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  415 MLSGETAHGKFPLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMS--EMFAYHATMMSNTLGTST-VVFTRTGFMAI 491
Cdd:PLN02765 344 LLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEPMShlESIASSAVRAAIKVKASViIVFTSSGRAAR 423
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  492 LLSHYRPSGTIYA--------------FTNEKKIQQRLaLYQGVCPIyMEFTDDAEETFANALATLLK--------QGMV 549
Cdd:PLN02765 424 LIAKYRPTMPVLSvviprlktnqlkwsFTGAFQARQCL-IVRGLFPM-LADPRHSAESTSATNESVLKvaldhgkaAGVI 501
                        490
                 ....*....|
gi 15237303  550 KKGEEIAIVQ 559
Cdd:PLN02765 502 KSHDRVVVCQ 511
PRK08187 PRK08187
pyruvate kinase; Validated
110-416 5.77e-34

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 135.14  E-value: 5.77e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  110 RKTKIVCTVgPS--TNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKdNTIAIMLDTKGPEVRSGDLP 187
Cdd:PRK08187 133 RRTRIMVTL-PSeaADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATG-RRCKILMDLAGPKIRTGAVA 210
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  188 QPI---MLDPGQEFTFT----IERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVV---DGGE 257
Cdd:PRK08187 211 GPLgktRLYTGDRLALVaqgpPRRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTharPKGL 290
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  258 -LKSRRHLNVRGKSATLPSITEKDWEDIKFGVENkVDFYAVSFVKDAQVVH----ELKKYLQNSGADIHVIVKIESADSI 332
Cdd:PRK08187 291 kLKPEKGLNFPDTALDLPALTEKDRADLDFVARH-ADLVGYSFVQSPGDVEalqaALAARRPDDWRKLGLVLKIETPRAV 369
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  333 PNLHSIITASDG-----AMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAV 407
Cdd:PRK08187 370 ANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMAA 449

                 ....*....
gi 15237303  408 RegADAVML 416
Cdd:PRK08187 450 R--AECVML 456
PRK14725 PRK14725
pyruvate kinase; Provisional
186-416 2.04e-29

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 122.75  E-value: 2.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  186 LPQPIMLDPGQEFTFTIE--------RGVSTPScVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGE 257
Cdd:PRK14725 329 VEQKLRLKVGDRLVLTRDdapgdpaqGDAPPAR-ISCTLPEAFRAARVGERVWFDDGKIGAVVVKVEADEVELRITHARP 407
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  258 ----LKSRRHLNVRGKSATLPSITEKDWEDIKFGVENkVDFYAVSFVKDAQVVHELKKYLQNSGA-DIHVIVKIESADSI 332
Cdd:PRK14725 408 ggskLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKH-ADIVALSFVRSPEDVRLLLDALEKLGAdDLGVVLKIETRRAF 486
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303  333 PNLHSIITA-----SDGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAV 407
Cdd:PRK14725 487 ENLPRILLEamrhpRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMAL 566

                 ....*....
gi 15237303  408 RegADAVML 416
Cdd:PRK14725 567 R--AECVML 573
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
466-559 8.55e-21

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 87.92  E-value: 8.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303   466 AYHATMMSNTLGTST-VVFTRTGFMAILLSHYRPSGTIYAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLL 544
Cdd:pfam02887   4 AHAAVEAAEELGAKAiVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVKVAK 83
                          90
                  ....*....|....*
gi 15237303   545 KQGMVKKGEEIAIVQ 559
Cdd:pfam02887  84 EAGLVKKGDLVVITA 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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