|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02623 |
PLN02623 |
pyruvate kinase |
1-579 |
0e+00 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 1102.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 1 MAQVVATRSIQGSMLSPNGGSVSTRsekLLKPASFAVKVLGNEAKRSGRVSVRSRRVVDTTVRSARVETEVIPVSPED-- 78
Cdd:PLN02623 2 AAQVVATRSIDSSILSSSSGSVSLD---LLSPLSFASKVLGSEARARRRVAVRRRAVTAASLRSKSQETEVIPVSPEDgg 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 79 VPNREEQLERLLEMQQFGDTSVGMWSKPTVRRKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLV 158
Cdd:PLN02623 79 ANFVEDNEEVLLEIQQLGETAVGMWSKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 159 KEYNAQTKDNTIAIMLDTKGPEVRSGDLPQPIMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSF 238
Cdd:PLN02623 159 KEYNAQSKDNVIAIMLDTKGPEVRSGDLPQPIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 239 MVKSKTKDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGA 318
Cdd:PLN02623 239 AVKSKTSDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 319 DIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRA 398
Cdd:PLN02623 319 DIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 399 EVSDIAIAVREGADAVMLSGETAHGKFPLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMSEMFAYHATMMSNTLGT 478
Cdd:PLN02623 399 EVSDIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEMFAFHATMMANTLGT 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 479 STVVFTRTGFMAILLSHYRPSGTIYAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIV 558
Cdd:PLN02623 479 SIIVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALV 558
|
570 580
....*....|....*....|.
gi 15237303 559 QSGTQPIWRSQSTHNIQVRKV 579
Cdd:PLN02623 559 QSGRQPIWRSESTHHIQVRKV 579
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
110-579 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 602.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKDNtIAIMLDTKGPEVRSGDLPQ- 188
Cdd:COG0469 3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRP-VAILLDLQGPKIRTGKFKEg 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 189 PIMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNVRG 268
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 269 KSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITASDGAMVA 348
Cdd:COG0469 162 VGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 349 RGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLK 428
Cdd:COG0469 242 RGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVE 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 429 AAGVMHTVALRTEATITSGEMPPNLGQAFKNHMSEMFAYHATMMSNTLGTST-VVFTRTGFMAILLSHYRPSGTIYAFTN 507
Cdd:COG0469 322 AVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAiVAFTESGSTARRISRYRPKVPILALTP 401
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15237303 508 EKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIVqSGTqPIWRSQSTHNIQVRKV 579
Cdd:COG0469 402 NERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVIT-AGV-PVGVPGTTNTLKVHRV 471
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
110-576 |
4.93e-173 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 498.73 E-value: 4.93e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYnAQTKDNTIAIMLDTKGPEVRSGDLPQ- 188
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREA-AEKLGRPVAILLDTKGPEIRTGEIKGg 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 189 PIMLDPGQEFTFTIE--RGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNV 266
Cdd:TIGR01064 80 EVKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGA-DIHVIVKIESADSIPNLHSIITASDGA 345
Cdd:TIGR01064 160 PGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAkDVKIIAKIENQEGVDNIDEIAEASDGI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 346 MVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
Cdd:TIGR01064 240 MVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 426 PLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMS--EMFAYHATMMSNTLGTST-VVFTRTGFMAILLSHYRPSGTI 502
Cdd:TIGR01064 320 PVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTitEAIALSAVEAAEKLDAKAiVVLTESGRTARLLSKYRPNAPI 399
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15237303 503 YAFTNEKKIQQRLALYQGVCPIYM-EFTDDAEETFANALATLLKQGMVKKGEEIAIVQSGTQPIwrSQSTHNIQV 576
Cdd:TIGR01064 400 IAVTPNERVARQLALYWGVFPFLVdEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGG--EGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
110-577 |
5.79e-152 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 445.22 E-value: 5.79e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKdNTIAIMLDTKGPEVRSGDLP-- 187
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG-GPVAIALDTKGPEIRTGLFKgg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 188 QPIMLDPGQEFTFTIE--RGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDS-VKCEVVDGGELKSRRHL 264
Cdd:cd00288 81 KDISLKAGDKFLVTTDpaAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 265 NVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITASDG 344
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 345 AMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGK 424
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 425 FPLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMS--EMFAYHATMMSNTLGTST-VVFTRTGFMAILLSHYRPSGT 501
Cdd:cd00288 321 YPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSttEAVAMSAVRAAFELGAKAiVVLTTSGRTARLVSKYRPNAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 502 IYAFTNEKKIQQRLALYQGVCPIYME-----FTDDAEETFANALATLLKQGMVKKGEEIAIVQSgtqpiWRSQSTHNIQV 576
Cdd:cd00288 401 IIAVTRNEQTARQLHLYRGVYPVLFEepkpgWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQG-----WPVGSGSTNTM 475
|
.
gi 15237303 577 R 577
Cdd:cd00288 476 R 476
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
110-444 |
4.86e-130 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 384.41 E-value: 4.86e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKdNTIAIMLDTKGPEVRSGDL--- 186
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTG-GTVAIALDTKGPEIRTGNTkdg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 187 PQPIMLDPGQEFTFTIE---RGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDS-VKCEVVDGGELKSRR 262
Cdd:pfam00224 81 KKDIELKAGDEMIVSTDakyKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 263 HLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITAS 342
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 343 DGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAH 422
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
|
330 340
....*....|....*....|..
gi 15237303 423 GKFPLKAAGVMHTVALRTEATI 444
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKAL 342
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02623 |
PLN02623 |
pyruvate kinase |
1-579 |
0e+00 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 1102.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 1 MAQVVATRSIQGSMLSPNGGSVSTRsekLLKPASFAVKVLGNEAKRSGRVSVRSRRVVDTTVRSARVETEVIPVSPED-- 78
Cdd:PLN02623 2 AAQVVATRSIDSSILSSSSGSVSLD---LLSPLSFASKVLGSEARARRRVAVRRRAVTAASLRSKSQETEVIPVSPEDgg 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 79 VPNREEQLERLLEMQQFGDTSVGMWSKPTVRRKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLV 158
Cdd:PLN02623 79 ANFVEDNEEVLLEIQQLGETAVGMWSKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 159 KEYNAQTKDNTIAIMLDTKGPEVRSGDLPQPIMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSF 238
Cdd:PLN02623 159 KEYNAQSKDNVIAIMLDTKGPEVRSGDLPQPIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 239 MVKSKTKDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGA 318
Cdd:PLN02623 239 AVKSKTSDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 319 DIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRA 398
Cdd:PLN02623 319 DIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 399 EVSDIAIAVREGADAVMLSGETAHGKFPLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMSEMFAYHATMMSNTLGT 478
Cdd:PLN02623 399 EVSDIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEMFAFHATMMANTLGT 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 479 STVVFTRTGFMAILLSHYRPSGTIYAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIV 558
Cdd:PLN02623 479 SIIVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALV 558
|
570 580
....*....|....*....|.
gi 15237303 559 QSGTQPIWRSQSTHNIQVRKV 579
Cdd:PLN02623 559 QSGRQPIWRSESTHHIQVRKV 579
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
110-579 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 602.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKDNtIAIMLDTKGPEVRSGDLPQ- 188
Cdd:COG0469 3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRP-VAILLDLQGPKIRTGKFKEg 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 189 PIMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNVRG 268
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 269 KSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITASDGAMVA 348
Cdd:COG0469 162 VGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 349 RGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLK 428
Cdd:COG0469 242 RGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVE 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 429 AAGVMHTVALRTEATITSGEMPPNLGQAFKNHMSEMFAYHATMMSNTLGTST-VVFTRTGFMAILLSHYRPSGTIYAFTN 507
Cdd:COG0469 322 AVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAiVAFTESGSTARRISRYRPKVPILALTP 401
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15237303 508 EKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIVqSGTqPIWRSQSTHNIQVRKV 579
Cdd:COG0469 402 NERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVIT-AGV-PVGVPGTTNTLKVHRV 471
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
110-561 |
1.10e-176 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 507.77 E-value: 1.10e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYnAQTKDNTIAIMLDTKGPEVRSGDLPQ- 188
Cdd:PRK05826 4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREI-AAKLGRPVAILLDLKGPKIRVGKFKEg 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 189 PIMLDPGQEFTFTIER-GVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNVR 267
Cdd:PRK05826 83 KITLKTGDKFTLDTDQkEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 268 GKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGA-DIHVIVKIESADSIPNLHSIITASDGAM 346
Cdd:PRK05826 163 GGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAVDNIDEIIEASDGIM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 347 VARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFP 426
Cdd:PRK05826 243 VARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYP 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 427 LKAAGVMHTVALRTEATITSGEMPPNLGQAFKNhMSEMFAYHATMMSNTLG--TSTVVFTRTGFMAILLSHYRPSGTIYA 504
Cdd:PRK05826 323 VEAVEAMARICKGAEKEFSINLSKHRLDRQFDR-IDEAIAMSAMYAANHLKgvKAIVALTESGRTARLISRFRPGAPIFA 401
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 15237303 505 FTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIVQSG 561
Cdd:PRK05826 402 VTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGD 458
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
110-576 |
4.93e-173 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 498.73 E-value: 4.93e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYnAQTKDNTIAIMLDTKGPEVRSGDLPQ- 188
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREA-AEKLGRPVAILLDTKGPEIRTGEIKGg 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 189 PIMLDPGQEFTFTIE--RGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNV 266
Cdd:TIGR01064 80 EVKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGA-DIHVIVKIESADSIPNLHSIITASDGA 345
Cdd:TIGR01064 160 PGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAkDVKIIAKIENQEGVDNIDEIAEASDGI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 346 MVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
Cdd:TIGR01064 240 MVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 426 PLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMS--EMFAYHATMMSNTLGTST-VVFTRTGFMAILLSHYRPSGTI 502
Cdd:TIGR01064 320 PVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTitEAIALSAVEAAEKLDAKAiVVLTESGRTARLLSKYRPNAPI 399
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15237303 503 YAFTNEKKIQQRLALYQGVCPIYM-EFTDDAEETFANALATLLKQGMVKKGEEIAIVQSGTQPIwrSQSTHNIQV 576
Cdd:TIGR01064 400 IAVTPNERVARQLALYWGVFPFLVdEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGG--EGGTNTIRV 472
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
110-579 |
3.75e-159 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 464.60 E-value: 3.75e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQtKDNTIAIMLDTKGPEVRSGDL--P 187
Cdd:PLN02762 25 RRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEE-KGFAVAVMMDTEGSEIHMGDLggA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 188 QPIMLDPGQEFTFTIER-GVSTPSC-VSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLN 265
Cdd:PLN02762 104 SSAKAEDGEEWTFTVRKfDGSRPEFtIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLLPRANLT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 266 -------VRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQN--SGADIHVIVKIESADSIPNLH 336
Cdd:PLN02762 184 fwrdgslVRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAArsRDSDIGVIAKIESLDSLKNLE 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 337 SIITASDGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVML 416
Cdd:PLN02762 264 EIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALML 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 417 SGETAHGKFPLKAAGVMHTVALRTE----ATITSGEMP-PNLGQAFKNHMSEMFAYHATMMSNTLGTSTV-VFTRTGFMA 490
Cdd:PLN02762 344 SGESAMGLYPEKALSVLRSVSLRMElwsrEEKRHEALElPQLSSSLSDRISEEICNSAAKMANNLGVDAIfVYTKHGHMA 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 491 ILLSHYRPSGTIYAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIVqSGTQPIWRSQS 570
Cdd:PLN02762 424 SLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGDLVIAV-SDLTPSSMLQS 502
|
....*....
gi 15237303 571 thnIQVRKV 579
Cdd:PLN02762 503 ---IQVRNV 508
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
110-577 |
5.79e-152 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 445.22 E-value: 5.79e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKdNTIAIMLDTKGPEVRSGDLP-- 187
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG-GPVAIALDTKGPEIRTGLFKgg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 188 QPIMLDPGQEFTFTIE--RGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDS-VKCEVVDGGELKSRRHL 264
Cdd:cd00288 81 KDISLKAGDKFLVTTDpaAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 265 NVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITASDG 344
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 345 AMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGK 424
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 425 FPLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMS--EMFAYHATMMSNTLGTST-VVFTRTGFMAILLSHYRPSGT 501
Cdd:cd00288 321 YPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSttEAVAMSAVRAAFELGAKAiVVLTTSGRTARLVSKYRPNAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 502 IYAFTNEKKIQQRLALYQGVCPIYME-----FTDDAEETFANALATLLKQGMVKKGEEIAIVQSgtqpiWRSQSTHNIQV 576
Cdd:cd00288 401 IIAVTRNEQTARQLHLYRGVYPVLFEepkpgWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQG-----WPVGSGSTNTM 475
|
.
gi 15237303 577 R 577
Cdd:cd00288 476 R 476
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
110-562 |
7.10e-131 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 390.95 E-value: 7.10e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTkDNTIAIMLDTKGPEVRSGDLP-- 187
Cdd:PRK09206 2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKT-GKKAAILLDTKGPEIRTMKLEgg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 188 QPIMLDPGQEFTFTIERGV-STPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNV 266
Cdd:PRK09206 81 NDVSLKAGQTFTFTTDKSVvGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYL-QNSGADIHVIVKIESADSIPNLHSIITASDGA 345
Cdd:PRK09206 161 PGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLkAHGGENIQIISKIENQEGLNNFDEILEASDGI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 346 MVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
Cdd:PRK09206 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 426 PLKAAGVMHTVALRTEATitsgeMPPNLGQAF---KNHMSEMFAYHATMMSNTLGTS-TVVFTRTGFMAILLSHYRPSGT 501
Cdd:PRK09206 321 PLEAVSIMATICERTDRV-----MNSRLESNNdnrKLRITEAVCRGAVETAEKLDAPlIVVATQGGKSARSVRKYFPDAT 395
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15237303 502 IYAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEI-----AIVQSGT 562
Cdd:PRK09206 396 ILALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVvmvsgALVPSGT 461
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
110-576 |
2.08e-130 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 393.91 E-value: 2.08e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYnAQTKDNTIAIMLDTKGPEVRSGDLP-Q 188
Cdd:PRK06354 8 RRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREA-SKKLGKTVGILQDLQGPKIRLGRFEdG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 189 PIMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKS--KTKDSVKCEVVDGGELKSRRHLNV 266
Cdd:PRK06354 87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEvdKADGELHCKVLVGGVLSNKKGVNF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYL-QNSGADIHVIVKIESADSIPNLHSIITASDGA 345
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIeEHNGKHIPIIAKIEKQEAIDNIDAILELCDGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 346 MVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 426 PLKAAGVMHTVALRTEATITSGEM---PPNLGQAFKNHMSEMFAYHATmmsnTLGTSTVV-FTRTGFMAILLSHYRPSGT 501
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRDIlskRPEFTTTITNAISQAVSHIAL----QLDAAAIVtLTKSGATARNVSKYRPKTP 402
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15237303 502 IYAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEeiAIVQSGTQPIWRSQSTHNIQV 576
Cdd:PRK06354 403 ILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGD--LVVITAGTLVGESGSTDLMKV 475
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
110-444 |
4.86e-130 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 384.41 E-value: 4.86e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKdNTIAIMLDTKGPEVRSGDL--- 186
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTG-GTVAIALDTKGPEIRTGNTkdg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 187 PQPIMLDPGQEFTFTIE---RGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDS-VKCEVVDGGELKSRR 262
Cdd:pfam00224 81 KKDIELKAGDEMIVSTDakyKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 263 HLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITAS 342
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 343 DGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAH 422
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
|
330 340
....*....|....*....|..
gi 15237303 423 GKFPLKAAGVMHTVALRTEATI 444
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKAL 342
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
110-558 |
6.81e-121 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 365.40 E-value: 6.81e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTkDNTIAIMLDTKGPEVRSGDLPQ- 188
Cdd:PRK06247 5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDET-GRPIGILADLQGPKLRLGRFADg 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 189 PIMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNVRG 268
Cdd:PRK06247 84 KVQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLPG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 269 KSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYlqnSGADIHVIVKIESADSIPNLHSIITASDGAMVA 348
Cdd:PRK06247 164 TVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKI---IGGRVPVMAKIEKPQAIDRLEAIVEASDAIMVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 349 RGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLK 428
Cdd:PRK06247 241 RGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 429 AAGVMHTVALRTEA-----TITSGEMPPNLGQAfknhmSEMFAYHATMMSNTLGTSTVV-FTRTGFMAILLSHYRPSGTI 502
Cdd:PRK06247 321 AVRTMARIIRQVERdptypPLIHAQRPQPEATK-----RDAISYAARDIAERLDLAALVaYTSSGDTALRAARERPPLPI 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 15237303 503 YAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIV 558
Cdd:PRK06247 396 LALTPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIV 451
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
109-555 |
6.35e-105 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 325.39 E-value: 6.35e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 109 RRKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKeynaQTKDNT---IAIMLDTKGPEVRSGD 185
Cdd:PLN02461 20 RPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLR----QAMANTgilCAVMLDTKGPEIRTGF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 186 LP--QPIMLDPGQEFTFTIERGVS-TPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKS--KTKDSVKCEVVDGGELKS 260
Cdd:PLN02461 96 LKdgKPVQLKQGQEITITTDYSIKgDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLScdVEAGTVRCRCENSAMLGE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 261 RRHLNVRGKSATLPSITEKDWEDI-KFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSII 339
Cdd:PLN02461 176 RKNVNLPGVVVDLPTLTEKDKEDIlQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDIL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 340 TASDGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGE 419
Cdd:PLN02461 256 AESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGE 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 420 TAHGKFPLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMS--EMFAYHATMMSNTLGTS-TVVFTRTGFMAILLSHY 496
Cdd:PLN02461 336 TAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSplESLASSAVRTANKVKASlIVVLTRGGTTARLVAKY 415
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15237303 497 RPSGTI--------------YAFTNEKKIQQRLaLYQGVCPIYME------FTDDAEETFANALATLLKQGMVKKGEEI 555
Cdd:PLN02461 416 RPAVPIlsvvvpeittdsfdWSCSDEAPARHSL-IYRGLIPVLAEgsakatDSESTEEILEAAIEHAKKKGLCKPGDSV 493
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
110-558 |
7.19e-104 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 322.87 E-value: 7.19e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKDNTIAIMLDTKGPEVRSGDL--P 187
Cdd:PTZ00066 38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARPNANLGILLDTKGPEIRTGFLknH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 188 QPIMLDPGQEFTFTIERG-VSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNV 266
Cdd:PTZ00066 118 KPITLKEGQTLKITTDYTfLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 267 RGKSATLPSITEKDWEDI-KFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITASDGA 345
Cdd:PTZ00066 198 PGVKVELPVIGEKDKNDIlNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGI 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 346 MVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
Cdd:PTZ00066 278 MVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKF 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 426 PLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMS--EMFAYHATMMSNTLGTS-TVVFTRTGFMAILLSHYRPSGTI 502
Cdd:PTZ00066 358 PVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSvqEAVARSAVETAEDINAKlIIALTETGNTARLISKYRPSCTI 437
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 15237303 503 YAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLLKQGMVKKGEEIAIV 558
Cdd:PTZ00066 438 LALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAV 493
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
136-560 |
3.23e-86 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 275.01 E-value: 3.23e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 136 MNVARMNMSHGDHASHKKVIDLVKEYNAQTKDNtIAIMLDTKGPEVRSGDLPQ-PIMLDPGQEFTFTIERGVS---TPSC 211
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVN-IAIALDTKGPEIRTGLFVGgEAVMERGATCYVTTDPAFAdkgTKDK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 212 VSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKD-SVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVEN 290
Cdd:PTZ00300 80 FYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEqTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 291 KVDFYAVSFVKDAQVVHELKKYLQNSGADIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPILQEEIIN 370
Cdd:PTZ00300 160 GVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILIS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 371 LCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLKAAGVMHTVALRTEATITSGEMP 450
Cdd:PTZ00300 240 KCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYVFF 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 451 PNLGQAFKNHMSEMFAYHATMMSN---TLGTSTVVFTRTGFMAILLSHYRPSGTIYAFTNEKKIQQRLALYQGVCPIYME 527
Cdd:PTZ00300 320 NSIKKLQPIPMSAEEAVCSSAVNSvyeTKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFFD 399
|
410 420 430
....*....|....*....|....*....|....*...
gi 15237303 528 -----FTDDAEETFANALATLLKQGMVKKGEEIAIVQS 560
Cdd:PTZ00300 400 aerlgHDEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHA 437
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
115-437 |
1.64e-84 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 267.20 E-value: 1.64e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 115 VCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKeynaqTKDNTIAIMLDTKGPEVRSGDLP-QPIMLD 193
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVK-----SLDDSIKILGDVQGPKIRLGEIKgEQITLQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 194 PGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNVRGKSATL 273
Cdd:PRK06739 81 AGDSFILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 274 PSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKKYLQNSGADI-HVIVKIESADSIPNLHSIITASDGAMVARGDL 352
Cdd:PRK06739 161 PAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKEADGIMIARGDL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 353 GAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLKAAGV 432
Cdd:PRK06739 241 GVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVST 320
|
....*
gi 15237303 433 MHTVA 437
Cdd:PRK06739 321 LRLVS 325
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
112-559 |
2.10e-62 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 214.53 E-value: 2.10e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 112 TKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKdNTIAIMLDTKGPEVRSGDLP-QPI 190
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTK-KLCAVMLDTVGPELQVINKTeKPI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 191 MLDPGQEFTFTIERGVSTPSCV-SVNYDDFVNDVEAGDMLLVdgGMMSFmVKSKTKdSVKCEV--VDGGEL--------- 258
Cdd:PLN02765 109 SLKAGNTVTLTPDQSKEASSEVlPINFPGLAKAVKPGDTIFV--GQYLF-TGSETT-SVWLEVdeVKGDDVvctvknsat 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 259 --KSRRHLNVRGKSATLPSITEKDWEDIK-FGVENKVDFYAVSFVKDAQVVHELKKYLQNSG-ADIHVIVKIESADSIPN 334
Cdd:PLN02765 185 laGSLFTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIENVEGLTH 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 335 LHSIITASDGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVaTNMLESMIVHPTPTRAEVSDIAIAVREGADAV 414
Cdd:PLN02765 265 FDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAI 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 415 MLSGETAHGKFPLKAAGVMHTVALRTEATITSGEMPPNLGQAFKNHMS--EMFAYHATMMSNTLGTST-VVFTRTGFMAI 491
Cdd:PLN02765 344 LLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEPMShlESIASSAVRAAIKVKASViIVFTSSGRAAR 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 492 LLSHYRPSGTIYA--------------FTNEKKIQQRLaLYQGVCPIyMEFTDDAEETFANALATLLK--------QGMV 549
Cdd:PLN02765 424 LIAKYRPTMPVLSvviprlktnqlkwsFTGAFQARQCL-IVRGLFPM-LADPRHSAESTSATNESVLKvaldhgkaAGVI 501
|
490
....*....|
gi 15237303 550 KKGEEIAIVQ 559
Cdd:PLN02765 502 KSHDRVVVCQ 511
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
110-416 |
5.77e-34 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 135.14 E-value: 5.77e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 110 RKTKIVCTVgPS--TNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKdNTIAIMLDTKGPEVRSGDLP 187
Cdd:PRK08187 133 RRTRIMVTL-PSeaADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATG-RRCKILMDLAGPKIRTGAVA 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 188 QPI---MLDPGQEFTFT----IERGVSTPSCVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVV---DGGE 257
Cdd:PRK08187 211 GPLgktRLYTGDRLALVaqgpPRRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTharPKGL 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 258 -LKSRRHLNVRGKSATLPSITEKDWEDIKFGVENkVDFYAVSFVKDAQVVH----ELKKYLQNSGADIHVIVKIESADSI 332
Cdd:PRK08187 291 kLKPEKGLNFPDTALDLPALTEKDRADLDFVARH-ADLVGYSFVQSPGDVEalqaALAARRPDDWRKLGLVLKIETPRAV 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 333 PNLHSIITASDG-----AMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAV 407
Cdd:PRK08187 370 ANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMAA 449
|
....*....
gi 15237303 408 RegADAVML 416
Cdd:PRK08187 450 R--AECVML 456
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
186-416 |
2.04e-29 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 122.75 E-value: 2.04e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 186 LPQPIMLDPGQEFTFTIE--------RGVSTPScVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTKDSVKCEVVDGGE 257
Cdd:PRK14725 329 VEQKLRLKVGDRLVLTRDdapgdpaqGDAPPAR-ISCTLPEAFRAARVGERVWFDDGKIGAVVVKVEADEVELRITHARP 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 258 ----LKSRRHLNVRGKSATLPSITEKDWEDIKFGVENkVDFYAVSFVKDAQVVHELKKYLQNSGA-DIHVIVKIESADSI 332
Cdd:PRK14725 408 ggskLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKH-ADIVALSFVRSPEDVRLLLDALEKLGAdDLGVVLKIETRRAF 486
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 333 PNLHSIITA-----SDGAMVARGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAV 407
Cdd:PRK14725 487 ENLPRILLEamrhpRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMAL 566
|
....*....
gi 15237303 408 RegADAVML 416
Cdd:PRK14725 567 R--AECVML 573
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
466-559 |
8.55e-21 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 87.92 E-value: 8.55e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237303 466 AYHATMMSNTLGTST-VVFTRTGFMAILLSHYRPSGTIYAFTNEKKIQQRLALYQGVCPIYMEFTDDAEETFANALATLL 544
Cdd:pfam02887 4 AHAAVEAAEELGAKAiVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVKVAK 83
|
90
....*....|....*
gi 15237303 545 KQGMVKKGEEIAIVQ 559
Cdd:pfam02887 84 EAGLVKKGDLVVITA 98
|
|
|