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Conserved domains on  [gi|15238760|ref|NP_200162|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 217-531 1.09e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.70  E-value: 1.09e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 217 IKAHDGAILAMKFSNDGKFLASSGEDGIVRVWKVVEDKKsrLRRDCLNEIdpscmyfEVNDLSQLkpvlvneekpkktte 296
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL--LRTLKGHTG-------PVRDVAAS--------------- 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 297 SFRKT-----SDSACVVFPPKvfriMEKPLYEFRGHTGEVLDISWSKDN-YLLSASMDKTVRLWKVGSNDCLGVF-AHNS 369
Cdd:cd00200  61 ADGTYlasgsSDKTIRLWDLE----TGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLrGHTD 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 370 YVTSVQFNPVNeNYFMSGSIDGKVRIWNISGCSVVdwADL---KDIISAVCYRPDGQGGIIGSLNGSCRFFNMSGeflel 446
Cdd:cd00200 137 WVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCV--ATLtghTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST----- 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 447 DSQIHLHnkkKSSNKRITGFQFLPqepTKVLVVSA--DSKVRILQGNNVVRKYKGVCKTRSLTSASLTSDGKHIVSACED 524
Cdd:cd00200 209 GKCLGTL---RGHENGVNSVAFSP---DGYLLASGseDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                ....*..
gi 15238760 525 SNVYIWS 531
Cdd:cd00200 283 GTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 217-531 1.09e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.70  E-value: 1.09e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 217 IKAHDGAILAMKFSNDGKFLASSGEDGIVRVWKVVEDKKsrLRRDCLNEIdpscmyfEVNDLSQLkpvlvneekpkktte 296
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL--LRTLKGHTG-------PVRDVAAS--------------- 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 297 SFRKT-----SDSACVVFPPKvfriMEKPLYEFRGHTGEVLDISWSKDN-YLLSASMDKTVRLWKVGSNDCLGVF-AHNS 369
Cdd:cd00200  61 ADGTYlasgsSDKTIRLWDLE----TGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLrGHTD 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 370 YVTSVQFNPVNeNYFMSGSIDGKVRIWNISGCSVVdwADL---KDIISAVCYRPDGQGGIIGSLNGSCRFFNMSGeflel 446
Cdd:cd00200 137 WVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCV--ATLtghTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST----- 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 447 DSQIHLHnkkKSSNKRITGFQFLPqepTKVLVVSA--DSKVRILQGNNVVRKYKGVCKTRSLTSASLTSDGKHIVSACED 524
Cdd:cd00200 209 GKCLGTL---RGHENGVNSVAFSP---DGYLLASGseDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                ....*..
gi 15238760 525 SNVYIWS 531
Cdd:cd00200 283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
217-531 5.27e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.35  E-value: 5.27e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 217 IKAHDGAILAMKFSNDGKFLASSGEDGIVRVWkvvedkksrlrrdclneidpscmyfevnDLSQLKPVLVneekpkktte 296
Cdd:COG2319 116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----------------------------DLATGKLLRT---------- 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 297 sFRKTSDSA-CVVFPP--------------KVFRIME-KPLYEFRGHTGEVLDISWSKD-NYLLSASMDKTVRLWKVGSN 359
Cdd:COG2319 158 -LTGHSGAVtSVAFSPdgkllasgsddgtvRLWDLATgKLLRTLTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATG 236

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 360 DCLGVFA-HNSYVTSVQFNPvNENYFMSGSIDGKVRIWNISGCSVVD-WADLKDIISAVCYRPDGQGGIIGSLNGSCRFF 437
Cdd:COG2319 237 KLLRTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRtLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 438 NmsgefLELDSQIHLHnkkKSSNKRITGFQFLPQEPTkVLVVSADSKVRI--LQGNNVVRKYKGVckTRSLTSASLTSDG 515
Cdd:COG2319 316 D-----LATGKLLRTL---TGHTGAVRSVAFSPDGKT-LASGSDDGTVRLwdLATGELLRTLTGH--TGAVTSVAFSPDG 384

                       330
                ....*....|....*.
gi 15238760 516 KHIVSACEDSNVYIWS 531
Cdd:COG2319 385 RTLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 319-355 5.24e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 5.24e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 15238760    319 KPLYEFRGHTGEVLDISWSKD-NYLLSASMDKTVRLWK 355
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
319-354 2.16e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.16e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 15238760   319 KPLYEFRGHTGEVLDISWSKD-NYLLSASMDKTVRLW 354
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 320-398 1.53e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760  320 PLYEFRGHTGEVLDISWSK--DNYLLSASMDKTVRLWKVGSND----------CLgVFAHNSYVTSVQFNPVNENYFMSG 387
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIPHNDesvkeikdpqCI-LKGHKKKISIIDWNPMNYYIMCSS 144

                         90
                 ....*....|.
gi 15238760  388 SIDGKVRIWNI 398
Cdd:PTZ00420 145 GFDSFVNIWDI 155
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 217-531 1.09e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.70  E-value: 1.09e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 217 IKAHDGAILAMKFSNDGKFLASSGEDGIVRVWKVVEDKKsrLRRDCLNEIdpscmyfEVNDLSQLkpvlvneekpkktte 296
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL--LRTLKGHTG-------PVRDVAAS--------------- 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 297 SFRKT-----SDSACVVFPPKvfriMEKPLYEFRGHTGEVLDISWSKDN-YLLSASMDKTVRLWKVGSNDCLGVF-AHNS 369
Cdd:cd00200  61 ADGTYlasgsSDKTIRLWDLE----TGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLrGHTD 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 370 YVTSVQFNPVNeNYFMSGSIDGKVRIWNISGCSVVdwADL---KDIISAVCYRPDGQGGIIGSLNGSCRFFNMSGeflel 446
Cdd:cd00200 137 WVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCV--ATLtghTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST----- 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 447 DSQIHLHnkkKSSNKRITGFQFLPqepTKVLVVSA--DSKVRILQGNNVVRKYKGVCKTRSLTSASLTSDGKHIVSACED 524
Cdd:cd00200 209 GKCLGTL---RGHENGVNSVAFSP---DGYLLASGseDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                ....*..
gi 15238760 525 SNVYIWS 531
Cdd:cd00200 283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
217-531 5.27e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.35  E-value: 5.27e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 217 IKAHDGAILAMKFSNDGKFLASSGEDGIVRVWkvvedkksrlrrdclneidpscmyfevnDLSQLKPVLVneekpkktte 296
Cdd:COG2319 116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----------------------------DLATGKLLRT---------- 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 297 sFRKTSDSA-CVVFPP--------------KVFRIME-KPLYEFRGHTGEVLDISWSKD-NYLLSASMDKTVRLWKVGSN 359
Cdd:COG2319 158 -LTGHSGAVtSVAFSPdgkllasgsddgtvRLWDLATgKLLRTLTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATG 236

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 360 DCLGVFA-HNSYVTSVQFNPvNENYFMSGSIDGKVRIWNISGCSVVD-WADLKDIISAVCYRPDGQGGIIGSLNGSCRFF 437
Cdd:COG2319 237 KLLRTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRtLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 438 NmsgefLELDSQIHLHnkkKSSNKRITGFQFLPQEPTkVLVVSADSKVRI--LQGNNVVRKYKGVckTRSLTSASLTSDG 515
Cdd:COG2319 316 D-----LATGKLLRTL---TGHTGAVRSVAFSPDGKT-LASGSDDGTVRLwdLATGELLRTLTGH--TGAVTSVAFSPDG 384

                       330
                ....*....|....*.
gi 15238760 516 KHIVSACEDSNVYIWS 531
Cdd:COG2319 385 RTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
319-531 2.05e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 2.05e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 319 KPLYEFRGHTGEVLDISWSKD-NYLLSASMDKTVRLWKVGSNDCLGVF-AHNSYVTSVQFNPvNENYFMSGSIDGKVRIW 396
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDgKTLASGSADGTVRLWDLATGKLLRTLtGHSGAVTSVAFSP-DGKLLASGSDDGTVRLW 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 397 NI-SGCSVVDWADLKDIISAVCYRPDGQGGIIGSLNGSCRFFNMSGEFLELDSQIHlhnkkkssNKRITGFQFLPQEPTk 475
Cdd:COG2319 190 DLaTGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH--------SGSVRSVAFSPDGRL- 260

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15238760 476 VLVVSADSKVRI--LQGNNVVRKYKGvcKTRSLTSASLTSDGKHIVSACEDSNVYIWS 531
Cdd:COG2319 261 LASGSADGTVRLwdLATGELLRTLTG--HSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
215-423 1.56e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 1.56e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 215 QDIKAHDGAILAMKFSNDGKFLASSGEDGIVRVWKVVEDkksrlrrdclneidpscmyfevndlsqlkpvlvneekpkkt 294
Cdd:COG2319 240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG----------------------------------------- 278

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 295 tesfrktsdsacvvfppkvfrimeKPLYEFRGHTGEVLDISWSKD-NYLLSASMDKTVRLWKVGSNDCLGVF-AHNSYVT 372
Cdd:COG2319 279 ------------------------ELLRTLTGHSGGVNSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLtGHTGAVR 334

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 15238760 373 SVQFNPvNENYFMSGSIDGKVRIWNI-SGCSVVDWADLKDIISAVCYRPDGQ 423
Cdd:COG2319 335 SVAFSP-DGKTLASGSDDGTVRLWDLaTGELLRTLTGHTGAVTSVAFSPDGR 385
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 323-547 4.92e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 4.92e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 323 EFRGHTGEVLDISWSKD-NYLLSASMDKTVRLWKVGSNDCLGVF-AHNSYVTSVQFNPvNENYFMSGSIDGKVRIWNI-S 399
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDgKLLATGSGDGTIKVWDLETGELLRTLkGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLeT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 400 GCSVVDWADLKDIISAVCYRPDGQggII--GSLNGSCRFFNM-SGEFLeldSQIHLHnkkkssNKRITGFQFLPQEPTkV 476
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGR--ILssSSRDKTIKVWDVeTGKCL---TTLRGH------TDWVNSVAFSPDGTF-V 150

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15238760 477 LVVSADSKVRI--LQGNNVVRKYKGvcKTRSLTSASLTSDGKHIVSACEDSNVYIWSNDEESETKKIRSFERF 547
Cdd:cd00200 151 ASSSQDGTIKLwdLRTGKCVATLTG--HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 215-397 1.67e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 1.67e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 215 QDIKAHDGAILAMKFSNDGKFLASSGEDGIVRVWkvvedkksrlrrdclneidpscmyfevnDLSqlkpvlvneekpkkt 294
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW----------------------------DLS--------------- 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 295 tesfrktsdsacvvfppkvfriMEKPLYEFRGHTGEVLDISWSKDNYLL-SASMDKTVRLWKVGSNDCLGVF-AHNSYVT 372
Cdd:cd00200 208 ----------------------TGKCLGTLRGHENGVNSVAFSPDGYLLaSGSEDGTIRVWDLRTGECVQTLsGHTNSVT 265

                       170       180
                ....*....|....*....|....*
gi 15238760 373 SVQFNPvNENYFMSGSIDGKVRIWN 397
Cdd:cd00200 266 SLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
217-358 7.23e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 7.23e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 217 IKAHDGAILAMKFSNDGKFLASSGEDGIVRVWkvvedkksrlrrdclneidpscmyfevnDLSQLKPVLVNEEKpkktte 296
Cdd:COG2319 284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW----------------------------DLATGKLLRTLTGH------ 329

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15238760 297 sfrkTSDSACVVFPP--------------KVFRI-MEKPLYEFRGHTGEVLDISWSKD-NYLLSASMDKTVRLWKVGS 358
Cdd:COG2319 330 ----TGAVRSVAFSPdgktlasgsddgtvRLWDLaTGELLRTLTGHTGAVTSVAFSPDgRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
324-531 1.43e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.86  E-value: 1.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 324 FRGHTGEVLDISWSKDN-YLLSASMDKTVRLWKVGSNDCLGVF-AHNSYVTSVQFNPvNENYFMSGSIDGKVRIWNI-SG 400
Cdd:COG2319  32 LLGLAAAVASLAASPDGaRLAAGAGDLTLLLLDAAAGALLATLlGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLaTG 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 401 CSVVDWADLKDIISAVCYRPDGQGGIIGSLNGSCRFFNM-SGEFLEldsQIHLHnkkkssNKRITGFQFLPQEptKVLVV 479
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLR---TLTGH------SGAVTSVAFSPDG--KLLAS 179

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15238760 480 -SADSKVRI--LQGNNVVRKYKGvcKTRSLTSASLTSDGKHIVSACEDSNVYIWS 531
Cdd:COG2319 180 gSDDGTVRLwdLATGKLLRTLTG--HTGAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 207-355 4.20e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 4.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 207 ELSALYQSQDIKAHDGAILAMKFSNDGKFLASSGEDGIVRVWKVVedkksrlrrdclneidpscmyfevndlsqlkpvlv 286
Cdd:cd00200 205 DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR----------------------------------- 249

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 287 neekpkkttesfrktsdsacvvfppkvfriMEKPLYEFRGHTGEVLDISWSKD-NYLLSASMDKTVRLWK 355
Cdd:cd00200 250 ------------------------------TGECVQTLSGHTNSVTSLAWSPDgKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 319-355 5.24e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 5.24e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 15238760    319 KPLYEFRGHTGEVLDISWSKD-NYLLSASMDKTVRLWK 355
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
319-354 2.16e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.16e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 15238760   319 KPLYEFRGHTGEVLDISWSKD-NYLLSASMDKTVRLW 354
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 217-249 4.80e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 4.80e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 15238760    217 IKAHDGAILAMKFSNDGKFLASSGEDGIVRVWK 249
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
217-248 2.74e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.74e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 15238760   217 IKAHDGAILAMKFSNDGKFLASSGEDGIVRVW 248
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 358-397 3.45e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 3.45e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15238760    358 SNDCLGVF-AHNSYVTSVQFNPvNENYFMSGSIDGKVRIWN 397
Cdd:smart00320   1 SGELLKTLkGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 320-398 1.53e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760  320 PLYEFRGHTGEVLDISWSK--DNYLLSASMDKTVRLWKVGSND----------CLgVFAHNSYVTSVQFNPVNENYFMSG 387
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIPHNDesvkeikdpqCI-LKGHKKKISIIDWNPMNYYIMCSS 144

                         90
                 ....*....|.
gi 15238760  388 SIDGKVRIWNI 398
Cdd:PTZ00420 145 GFDSFVNIWDI 155
WD40 pfam00400
WD domain, G-beta repeat;
361-397 2.07e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.07e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 15238760   361 CLGVF-AHNSYVTSVQFNPvNENYFMSGSIDGKVRIWN 397
Cdd:pfam00400   3 LLKTLeGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 236-439 1.30e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760  236 LASSGEDGIVRVWKV--------VEDKKSRLRRDCLNEIDPSCMYFEVNDLSqlkpVLVNEEKPKKTTESFRKTSDSACV 307
Cdd:PLN00181 548 VASSNFEGVVQVWDVarsqlvteMKEHEKRVWSIDYSSADPTLLASGSDDGS----VKLWSINQGVSIGTIKTKANICCV 623

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760  308 VFPP-------------KVF----RIMEKPLYEFRGHTGEVLDISWSKDNYLLSASMDKTVRLWKV-----GSNDC-LGV 364
Cdd:PLN00181 624 QFPSesgrslafgsadhKVYyydlRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLsmsisGINETpLHS 703

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760  365 FAHNSYVTSVQFNPVNENYFMSGSIDGKVRIW--------------NISGCSVVDWADLKDIISAVCYRPDGQGGIIGSL 430
Cdd:PLN00181 704 FMGHTNVKNFVGLSVSDGYIATGSETNEVFVYhkafpmpvlsykfkTIDPVSGLEVDDASQFISSVCWRGQSSTLVAANS 783


                 ....*....
gi 15238760  431 NGSCRFFNM 439
Cdd:PLN00181 784 TGNIKILEM 792
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 219-276 1.26e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 1.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15238760   219 AHDGAILAMKFSNDGKFLASSGEDGIVRVWKvVEDKKSRLRRDCLNEiDPSCMYFEVN 276
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLD-AENGKIVHHFSAGSD-LITCLGWGEN 91
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
188-405 2.40e-03

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 40.78  E-value: 2.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 188 GYGDVISRV------KVKHCKK------QAKELSALY-QSQDIKAHDGAILAMKFSNDGKFLASsGEDGIVRVWKVVEDK 254
Cdd:COG5170  42 ATGDKGGRVvlfereKSYGCEYkfftefQSHELEFDYlKSLEIEEKINAIEWFDDTGRNHFLLS-TNDKTIKLWKIYEKN 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 255 KSRLRRDCLNEIDPSCMYFEVNDLSQLKPVLVNEEkpkkttesfrktsDSACVVFPPKVFRimekplyefRGHTGEVLDI 334
Cdd:COG5170 121 LKVVAENNLSDSFHSPMGGPLTSTKELLLPRLSEH-------------DEIIAAKPCRVYA---------NAHPYHINSI 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238760 335 SWSKDNYLLSASMDKTVRLWKV----GSNDCLGVFAHN-----SYVTSVQFNPVNENYFMSGSIDGKVRIWNISGCSVVD 405
Cdd:COG5170 179 SFNSDKETLLSADDLRINLWNLeiidGSFNIVDIKPHNmeeltEVITSAEFHPEMCNVFMYSSSKGEIKLNDLRQSALCD 258
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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