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Conserved domains on  [gi|186532568|ref|NP_200663|]
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ETO1-like 2 [Arabidopsis thaliana]

Protein Classification

ETO1 family protein( domain architecture ID 13031935)

ETO1 family protein similar to Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) that is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 208-290 1.63e-36

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 132.25  E-value: 1.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 208 DISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEIDFSENGISIEAMLALNIYSRIKRVDLFRVETVFELLQLA 287
Cdd:cd18190    1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELA 80


                 ...
gi 186532568 288 SKF 290
Cdd:cd18190   81 SKF 83
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 737-907 1.44e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 77.85  E-value: 1.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 737 KGQALNNLGSIYINLGMLDQAETAYKNAIEI--KHTRARQGLARVYFLKNQRKEACEEMTKLIEKS-------CSKAAAY 807
Cdd:COG2956   75 RAEALLELAQDYLKAGLLDRAEELLEKLLELdpDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGpenahayCELAELY 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 808 EKRSEYcerEKAKEDLDMATTLDPLRTYPYRYRAAVLMDDQRETEAVEELSKAIAFRPE-LQTLHLRAAFHEATGNLSLA 886
Cdd:COG2956  155 LEQGDY---DEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDyLPALPRLAELYEKLGDPEEA 231

                        170       180
                 ....*....|....*....|.
gi 186532568 887 TQDCEAALCLDPNHTETLHLY 907
Cdd:COG2956  232 LELLRKALELDPSDDLLLALA 252
PEP_TPR_lipo super family cl37187
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 395-909 2.33e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


The actual alignment was detected with superfamily member TIGR02917:

Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 58.17  E-value: 2.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  395 LERTREFARTNWQkalslhqMGCVLFERKDYKAAQFHFRLASSLGhvYS----LAGVSRTEYKQGKRYSAYRLMNFLISN 470
Cdd:TIGR02917  49 LQKDPNDAEARFL-------LGKIYLALGDYAAAEKELRKALSLG--YPknqvLPLLARAYLLQGKFQQVLDELPGKTLL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  471 HKPHGWMYQE-RSLYNVGVEKL----KDLATATELDPTLSFPYKYRAVMKFEQKQIKEAFQEIDRLIQFKLSP-ECLELR 544
Cdd:TIGR02917 120 DDEGAAELLAlRGLAYLGLGQLelaqKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNvDALLLK 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  545 AWLYLATGDRESCLRDLRAVLSLEPNYVvfggKMRDDLVEAL--TAQCIEVESEADcwvrlfdrwsavddvaslavvhQM 622
Cdd:TIGR02917 200 GDLLLSLGNIELALAAYRKAIALRPNNI----AVLLALATILieAGEFEEAEKHAD----------------------AL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  623 LQNDPSKNFLRFRQSLLLLRLNCQGAAMRCLRMAWNLATSEAERLVYEGWLLYDMG-------YVEETLTKAEEAISIQR 695
Cdd:TIGR02917 254 LKKAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGnleqayqYLNQILKYAPNSHQARR 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  696 SFEAFFLKayaladkNLDADEISCVVQVLEEalKCPSDGlrkgQALNNLGSIYINLGMLDQA----ETAYKNAIEIKHTR 771
Cdd:TIGR02917 334 LLASIQLR-------LGRVDEAIATLSPALG--LDPDDP----AALSLLGEAYLALGDFEKAaeylAKATELDPENAAAR 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  772 ARQGLArvYFLKNQRKEACEEMT-------KLIEKSCSKAAAYEKRSEYCEREKAKEDLDMATTLDPLrtyPYRYRAAVL 844
Cdd:TIGR02917 401 TQLGIS--KLSQGDPSEAIADLEtaaqldpELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNAS---LHNLLGAIY 475

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186532568  845 MDDQRETEAVEELSKAIAFRPE-LQTLHLRAAFHEATGNLSLATQDCEAALCLDPNHTETLHLYSR 909
Cdd:TIGR02917 476 LGKGDLAKAREAFEKALSIEPDfFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAG 541
 
Name Accession Description Interval E-value
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 208-290 1.63e-36

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 132.25  E-value: 1.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 208 DISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEIDFSENGISIEAMLALNIYSRIKRVDLFRVETVFELLQLA 287
Cdd:cd18190    1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELA 80


                 ...
gi 186532568 288 SKF 290
Cdd:cd18190   81 SKF 83
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 737-907 1.44e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 77.85  E-value: 1.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 737 KGQALNNLGSIYINLGMLDQAETAYKNAIEI--KHTRARQGLARVYFLKNQRKEACEEMTKLIEKS-------CSKAAAY 807
Cdd:COG2956   75 RAEALLELAQDYLKAGLLDRAEELLEKLLELdpDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGpenahayCELAELY 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 808 EKRSEYcerEKAKEDLDMATTLDPLRTYPYRYRAAVLMDDQRETEAVEELSKAIAFRPE-LQTLHLRAAFHEATGNLSLA 886
Cdd:COG2956  155 LEQGDY---DEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDyLPALPRLAELYEKLGDPEEA 231

                        170       180
                 ....*....|....*....|.
gi 186532568 887 TQDCEAALCLDPNHTETLHLY 907
Cdd:COG2956  232 LELLRKALELDPSDDLLLALA 252
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 395-909 2.33e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 58.17  E-value: 2.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  395 LERTREFARTNWQkalslhqMGCVLFERKDYKAAQFHFRLASSLGhvYS----LAGVSRTEYKQGKRYSAYRLMNFLISN 470
Cdd:TIGR02917  49 LQKDPNDAEARFL-------LGKIYLALGDYAAAEKELRKALSLG--YPknqvLPLLARAYLLQGKFQQVLDELPGKTLL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  471 HKPHGWMYQE-RSLYNVGVEKL----KDLATATELDPTLSFPYKYRAVMKFEQKQIKEAFQEIDRLIQFKLSP-ECLELR 544
Cdd:TIGR02917 120 DDEGAAELLAlRGLAYLGLGQLelaqKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNvDALLLK 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  545 AWLYLATGDRESCLRDLRAVLSLEPNYVvfggKMRDDLVEAL--TAQCIEVESEADcwvrlfdrwsavddvaslavvhQM 622
Cdd:TIGR02917 200 GDLLLSLGNIELALAAYRKAIALRPNNI----AVLLALATILieAGEFEEAEKHAD----------------------AL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  623 LQNDPSKNFLRFRQSLLLLRLNCQGAAMRCLRMAWNLATSEAERLVYEGWLLYDMG-------YVEETLTKAEEAISIQR 695
Cdd:TIGR02917 254 LKKAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGnleqayqYLNQILKYAPNSHQARR 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  696 SFEAFFLKayaladkNLDADEISCVVQVLEEalKCPSDGlrkgQALNNLGSIYINLGMLDQA----ETAYKNAIEIKHTR 771
Cdd:TIGR02917 334 LLASIQLR-------LGRVDEAIATLSPALG--LDPDDP----AALSLLGEAYLALGDFEKAaeylAKATELDPENAAAR 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  772 ARQGLArvYFLKNQRKEACEEMT-------KLIEKSCSKAAAYEKRSEYCEREKAKEDLDMATTLDPLrtyPYRYRAAVL 844
Cdd:TIGR02917 401 TQLGIS--KLSQGDPSEAIADLEtaaqldpELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNAS---LHNLLGAIY 475

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186532568  845 MDDQRETEAVEELSKAIAFRPE-LQTLHLRAAFHEATGNLSLATQDCEAALCLDPNHTETLHLYSR 909
Cdd:TIGR02917 476 LGKGDLAKAREAFEKALSIEPDfFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAG 541
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 208-303 2.12e-07

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 49.61  E-value: 2.12e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568   208 DISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEIDFSEngISIEAMLALNIYSRIKRVDLFRvETVFELLQLA 287
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD--VSPEDFRALLNFLYTGKLDLPE-ENVEELLELA 77

                           90
                   ....*....|....*.
gi 186532568   288 SKFCCDDLKSECEARL 303
Cdd:smart00225  78 DYLQIPGLVELCEEFL 93
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 653-800 1.23e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.19  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 653 LRMAWNLATSEAERLVYEGWLLYDMGYVEETLTKAEEAISIQRSFEAFFLKAYALADKNLDADEISCVVQVLEEALKC-P 731
Cdd:COG5010    6 GFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLdP 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186532568 732 SDGlrkgQALNNLGSIYINLGMLDQAETAYKNAIEIK--HTRARQGLARVYFLKNQRKEACEEMTKLIEKS 800
Cdd:COG5010   86 NNP----ELYYNLALLYSRSGDKDEAKEYYEKALALSpdNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 782-899 1.26e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 48.83  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  782 LKNQRKEACEEMTKLIEKSCSK-------AAAYEKRSEY-C---EREKAKEDLDMATTLDPLRTYPYRYRAAVLMDDQRE 850
Cdd:TIGR00990 302 PESKADESYEEAARAFEKALDLgklgekeAIALNLRGTFkClkgKHLEALADLSKSIELDPRVTQSYIKRASMNLELGDP 381

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 186532568  851 TEAVEELSKAIAFRPELQTLHL-RAAFHEATGNLSLATQDCEAALCLDPN 899
Cdd:TIGR00990 382 DKAEEDFDKALKLNSEDPDIYYhRAQLHFIKGEFAQAGKDYQKSIDLDPD 431
TPR_1 pfam00515
Tetratricopeptide repeat;
739-770 1.62e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.71  E-value: 1.62e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 186532568  739 QALNNLGSIYINLGMLDQAETAYKNAIEIKHT 770
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 739-767 5.32e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 38.20  E-value: 5.32e-04
                           10        20
                   ....*....|....*....|....*....
gi 186532568   739 QALNNLGSIYINLGMLDQAETAYKNAIEI 767
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALEL 30
 
Name Accession Description Interval E-value
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 208-290 1.63e-36

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 132.25  E-value: 1.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 208 DISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEIDFSENGISIEAMLALNIYSRIKRVDLFRVETVFELLQLA 287
Cdd:cd18190    1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELA 80


                 ...
gi 186532568 288 SKF 290
Cdd:cd18190   81 SKF 83
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 737-907 1.44e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 77.85  E-value: 1.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 737 KGQALNNLGSIYINLGMLDQAETAYKNAIEI--KHTRARQGLARVYFLKNQRKEACEEMTKLIEKS-------CSKAAAY 807
Cdd:COG2956   75 RAEALLELAQDYLKAGLLDRAEELLEKLLELdpDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGpenahayCELAELY 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 808 EKRSEYcerEKAKEDLDMATTLDPLRTYPYRYRAAVLMDDQRETEAVEELSKAIAFRPE-LQTLHLRAAFHEATGNLSLA 886
Cdd:COG2956  155 LEQGDY---DEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDyLPALPRLAELYEKLGDPEEA 231

                        170       180
                 ....*....|....*....|.
gi 186532568 887 TQDCEAALCLDPNHTETLHLY 907
Cdd:COG2956  232 LELLRKALELDPSDDLLLALA 252
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 699-909 1.75e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 77.85  E-value: 1.75e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 699 AFFLKAYALADKNLDADEISCVVQVLEEALKCPSDGLrkgQALNNLGSIYINLGMLDQAETAYKNAIEIKHTR--ARQGL 776
Cdd:COG2956    6 AAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETV---EAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRaeALLEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 777 ARVYFLKNQRKEACEEMTKLIEKSCSKAAAYEKRSEYCER----EKAKEDLDMATTLDPLRTYPYRYRAAVLMDDQRETE 852
Cdd:COG2956   83 AQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQegdwEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDE 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 186532568 853 AVEELSKAIAFRPE-LQTLHLRAAFHEATGNLSLATQDCEAALCLDPNHTETLHLYSR 909
Cdd:COG2956  163 AIEALEKALKLDPDcARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAE 220
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
739-905 1.60e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.19  E-value: 1.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 739 QALNNLGSIYINLGMLDQAETAYKNAIEIK--HTRARQGLARVYFLKNQRKEACEEMTKLIEkscskaaayekrseycer 816
Cdd:COG0457    9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDpdDAEALYNLGLAYLRLGRYEEALADYEQALE------------------ 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 817 ekakedldmattLDPLRTYPYRYRAAVLMDDQRETEAVEELSKAIAFRPEL-QTLHLRAAFHEATGNLSLATQDCEAALC 895
Cdd:COG0457   71 ------------LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDaEALYNLGLALLELGRYDEAIEAYERALE 138

                        170
                 ....*....|
gi 186532568 896 LDPNHTETLH 905
Cdd:COG0457  139 LDPDDADALY 148
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
698-879 4.63e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 4.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 698 EAFFLKAYALADKNLDADEISCvvqvLEEALKCPSDglrKGQALNNLGSIYINLGMLDQAETAYKNAIEIK--HTRARQG 775
Cdd:COG0457    9 EAYNNLGLAYRRLGRYEEAIED----YEKALELDPD---DAEALYNLGLAYLRLGRYEEALADYEQALELDpdDAEALNN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 776 LARVYFLKNQRKEACEEMTKLIEKSCSKAAAYEKRSEYCER----EKAKEDLDMATTLDPLRTYPYRYRAAVLMDDQRET 851
Cdd:COG0457   82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLElgryDEAIEAYERALELDPDDADALYNLGIALEKLGRYE 161

                        170       180
                 ....*....|....*....|....*...
gi 186532568 852 EAVEELSKAIAFRPELQTLHLRAAFHEA 879
Cdd:COG0457  162 EALELLEKLEAAALAALLAAALGEAALA 189
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
623-879 4.51e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 4.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 623 LQNDPSKNFLRFRQSLLLLRLNCQGAAMRCLRMAWNLATSEAERLVYEGWLLYDMGYVEETLTKAEEAISIQ-RSFEAFF 701
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDpDDAEALN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 702 LKAYALADKNLDADEISCvvqvLEEALKCPSDglrKGQALNNLGSIYINLGMLDQAETAYKNAIEI--KHTRARQGLARV 779
Cdd:COG0457   81 NLGLALQALGRYEEALED----YDKALELDPD---DAEALYNLGLALLELGRYDEAIEAYERALELdpDDADALYNLGIA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 780 YFLKNQRKEAceemtkliEKSCSKAAAYEKRSEYCEREKAKEDLDMATTLDPLRTYPYRYRAAVLMDDQRETEAVEELSK 859
Cdd:COG0457  154 LEKLGRYEEA--------LELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLL 225

                        250       260
                 ....*....|....*....|
gi 186532568 860 AIAFRPELQTLHLRAAFHEA 879
Cdd:COG0457  226 ALALLLALRLAALALYQYRA 245
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 620-912 4.13e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.47  E-value: 4.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 620 HQMLQNDPSKNFLRFRQSLLLLRLNCQGAAMRCLRMAWNLATSEAERLVYEGWLLYDMGYVEETLTKAEEAISIQRSFEA 699
Cdd:COG3914    5 ALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 700 fflkAYALADKNLDADEISCVVQVLEEAlkcPSDGlrkgQALNNLGSIYINLGMLDQAETAYKNAIEIK--HTRARQGLA 777
Cdd:COG3914   85 ----ALLLQALGRYEEALALYRRALALN---PDNA----EALFNLGNLLLALGRLEEALAALRRALALNpdFAEAYLNLG 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 778 RVYFLKNQRKEAceemtkliekscskAAAYEKrseycerekakedldmATTLDPLRTYPYRYRAAVLMDDQRETEAVEEL 857
Cdd:COG3914  154 EALRRLGRLEEA--------------IAALRR----------------ALELDPDNAEALNNLGNALQDLGRLEEAIAAY 203

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 186532568 858 SKAIAFRPE---LQTLHLRAAFHEATGNLSLATQDCEAALCLDPNHTETLHLYSRSKD 912
Cdd:COG3914  204 RRALELDPDnadAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDD 261
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
687-872 3.67e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 58.00  E-value: 3.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 687 AEEAISIQRSFEAFFLKAYALADKNLDADEIscvVQVLEEALKCPsdglRKGQALNNLGSIYINLGMLDQAETAYKNAIE 766
Cdd:COG4785   29 LLFAAVLALAIALADLALALAAAALAAAALA---AERIDRALALP----DLAQLYYERGVAYDSLGDYDLAIADFDQALE 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 767 IKHtrarqGLARVYflkNQRkeaceemtkliekscskAAAYEKRSEYcerEKAKEDLDMATTLDPLRTYPYRYRAAVLMD 846
Cdd:COG4785  102 LDP-----DLAEAY---NNR-----------------GLAYLLLGDY---DAALEDFDRALELDPDYAYAYLNRGIALYY 153

                        170       180
                 ....*....|....*....|....*.
gi 186532568 847 DQRETEAVEELSKAIAFRPELQTLHL 872
Cdd:COG4785  154 LGRYELAIADLEKALELDPNDPERAL 179
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 739-866 3.82e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.97  E-value: 3.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 739 QALNNLGSIYINLGMLDQAETAYKNAIEI--KHTRARQGLARVYFLKNQRKEACEEMTKLIEKS-------CSKAAAYEK 809
Cdd:COG4783    5 EALYALAQALLLAGDYDEAEALLEKALELdpDNPEAFALLGEILLQLGDLDEAIVLLHEALELDpdepearLNLGLALLK 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 186532568 810 RSEYcerEKAKEDLDMATTLDPLRTYPYRYRAAVLMDDQRETEAVEELSKAIAFRPE 866
Cdd:COG4783   85 AGDY---DEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 721-866 1.44e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 54.24  E-value: 1.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 721 VQVLEEALKC-PSDGlrkgQALNNLGSIYINLGMLDQAETAYKNAIEI--KHTRARQGLARVYFLKNQrkeaceemtkli 797
Cdd:COG4235    3 IARLRQALAAnPNDA----EGWLLLGRAYLRLGRYDEALAAYEKALRLdpDNADALLDLAEALLAAGD------------ 66

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186532568 798 ekscskaaayekrseyceREKAKEDLDMATTLDPLRTYPYRYRAAVLMDDQRETEAVEELSKAIAFRPE 866
Cdd:COG4235   67 ------------------TEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPA 117
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 395-909 2.33e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 58.17  E-value: 2.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  395 LERTREFARTNWQkalslhqMGCVLFERKDYKAAQFHFRLASSLGhvYS----LAGVSRTEYKQGKRYSAYRLMNFLISN 470
Cdd:TIGR02917  49 LQKDPNDAEARFL-------LGKIYLALGDYAAAEKELRKALSLG--YPknqvLPLLARAYLLQGKFQQVLDELPGKTLL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  471 HKPHGWMYQE-RSLYNVGVEKL----KDLATATELDPTLSFPYKYRAVMKFEQKQIKEAFQEIDRLIQFKLSP-ECLELR 544
Cdd:TIGR02917 120 DDEGAAELLAlRGLAYLGLGQLelaqKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNvDALLLK 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  545 AWLYLATGDRESCLRDLRAVLSLEPNYVvfggKMRDDLVEAL--TAQCIEVESEADcwvrlfdrwsavddvaslavvhQM 622
Cdd:TIGR02917 200 GDLLLSLGNIELALAAYRKAIALRPNNI----AVLLALATILieAGEFEEAEKHAD----------------------AL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  623 LQNDPSKNFLRFRQSLLLLRLNCQGAAMRCLRMAWNLATSEAERLVYEGWLLYDMG-------YVEETLTKAEEAISIQR 695
Cdd:TIGR02917 254 LKKAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGnleqayqYLNQILKYAPNSHQARR 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  696 SFEAFFLKayaladkNLDADEISCVVQVLEEalKCPSDGlrkgQALNNLGSIYINLGMLDQA----ETAYKNAIEIKHTR 771
Cdd:TIGR02917 334 LLASIQLR-------LGRVDEAIATLSPALG--LDPDDP----AALSLLGEAYLALGDFEKAaeylAKATELDPENAAAR 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  772 ARQGLArvYFLKNQRKEACEEMT-------KLIEKSCSKAAAYEKRSEYCEREKAKEDLDMATTLDPLrtyPYRYRAAVL 844
Cdd:TIGR02917 401 TQLGIS--KLSQGDPSEAIADLEtaaqldpELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNAS---LHNLLGAIY 475

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186532568  845 MDDQRETEAVEELSKAIAFRPE-LQTLHLRAAFHEATGNLSLATQDCEAALCLDPNHTETLHLYSR 909
Cdd:TIGR02917 476 LGKGDLAKAREAFEKALSIEPDfFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAG 541
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 705-831 2.78e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 53.66  E-value: 2.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 705 YALADKNLDADEISCVVQVLEEALKC-PSDGlrkgQALNNLGSIYINLGMLDQAETAYKNAIEI--KHTRARQGLARVYF 781
Cdd:COG4783    8 YALAQALLLAGDYDEAEALLEKALELdPDNP----EAFALLGEILLQLGDLDEAIVLLHEALELdpDEPEARLNLGLALL 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 186532568 782 LKNQRKEACEEMTKLIEKSCSKAAAYEKRSEYCER----EKAKEDLDMATTLDP 831
Cdd:COG4783   84 KAGDYDEALALLEKALKLDPEHPEAYLRLARAYRAlgrpDEAIAALEKALELDP 137
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 207-290 7.78e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 50.63  E-value: 7.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 207 SDISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEIDFseNGISIEAMLAL--NIYSRikRVDLfRVETVFELL 284
Cdd:cd18186    2 CDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIEL--DDVSPEAFEALldYIYTG--ELEL-SEENVEELL 76


                 ....*.
gi 186532568 285 QLASKF 290
Cdd:cd18186   77 AAADKL 82
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 771-900 9.45e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.12  E-value: 9.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 771 RARQGLARVYFLKNQRKEACEEMTKLIEKSCSKAAAYEKRSEYCER----EKAKEDLDMATTLDPLRTYPYRYRAAVLMD 846
Cdd:COG4783    5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQlgdlDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 186532568 847 DQRETEAVEELSKAIAFRPELQTLHLR-AAFHEATGNLSLATQDCEAALCLDPNH 900
Cdd:COG4783   85 AGDYDEALALLEKALKLDPEHPEAYLRlARAYRALGRPDEAIAALEKALELDPDD 139
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 204-297 1.75e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 50.70  E-value: 1.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 204 DEVSDISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEIDFseNGISIEA--MLALNIYSriKRVDL--FRVET 279
Cdd:cd18287   20 EEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIEL--KDTNAEAfkALLKYIYT--GRLTLtdLKEDV 95

                         90
                 ....*....|....*...
gi 186532568 280 VFELLQLASKFCCDDLKS 297
Cdd:cd18287   96 LLDVLGLAHQYGFEELEA 113
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 208-303 2.12e-07

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 49.61  E-value: 2.12e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568   208 DISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEIDFSEngISIEAMLALNIYSRIKRVDLFRvETVFELLQLA 287
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD--VSPEDFRALLNFLYTGKLDLPE-ENVEELLELA 77

                           90
                   ....*....|....*.
gi 186532568   288 SKFCCDDLKSECEARL 303
Cdd:smart00225  78 DYLQIPGLVELCEEFL 93
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 380-894 6.08e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.55  E-value: 6.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  380 VGMEEKLT-TDTMLILLE-RTREFART-----NWQK-----ALSLHQMGCVLFERKDYKAAQFHFRLASSL--GHVYSLA 445
Cdd:TIGR02917 424 AQLDPELGrADLLLILSYlRSGQFDKAlaaakKLEKkqpdnASLHNLLGAIYLGKGDLAKAREAFEKALSIepDFFPAAA 503

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  446 GVSRTEYKQGKRYSAY-RLMNFLISNHKPHGWMYQERSLYNVG---VEKLKDLATATELDPTLSFPYKYRAVMKFEQKQI 521
Cdd:TIGR02917 504 NLARIDIQEGNPDDAIqRFEKVLTIDPKNLRAILALAGLYLRTgneEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQL 583

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  522 KEAFqEIDRLIQ--FKLSPECLELRAWLYLATGDRESCLRDLRAVLSLEPNYVvfggkmrddLVEALTAQCIEVESEADc 599
Cdd:TIGR02917 584 KKAL-AILNEAAdaAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSA---------LALLLLADAYAVMKNYA- 652

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  600 wvrlfdrwsavddvASLAVVHQMLQNDPSKNFLRFRQSLLLLRLNCQGAAMRCLRMAWNLATSEAERLVYEGWLLYDMGY 679
Cdd:TIGR02917 653 --------------KAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKD 718

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  680 VEETLTKAEEAISIQRSFEAFFLKAYAL--ADKNLDAdeiscvVQVLEEALKCPSDGLRkgqALNNLGSIYINLGMLDQA 757
Cdd:TIGR02917 719 YPAAIQAYRKALKRAPSSQNAIKLHRALlaSGNTAEA------VKTLEAWLKTHPNDAV---LRTALAELYLAQKDYDKA 789

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  758 ETAYKNAIEI--KHTRARQGLARVYflknqrkeaceemtklIEKSCSKAAAYEKRSeyceREKAKEDLDMATTLdplrty 835
Cdd:TIGR02917 790 IKHYQTVVKKapDNAVVLNNLAWLY----------------LELKDPRALEYAERA----LKLAPNIPAILDTL------ 843

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186532568  836 pyryrAAVLMDDQRETEAVEELSKAIAFRPELQT--LHLRAAFHeATGNLSLATQDCEAAL 894
Cdd:TIGR02917 844 -----GWLLVEKGEADRALPLLRKAVNIAPEAAAirYHLALALL-ATGRKAEARKELDKLL 898
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 209-290 6.31e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 47.66  E-value: 6.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 209 ISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEIDFSEngISIEAMLALNIYSRIKRVDLFrVETVFELLQLAS 288
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRD--ISPEDFRALLEFLYGGKRDLD-ASNLLELLEAAN 77


                 ..
gi 186532568 289 KF 290
Cdd:cd01165   78 FL 79
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 653-800 1.23e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.19  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 653 LRMAWNLATSEAERLVYEGWLLYDMGYVEETLTKAEEAISIQRSFEAFFLKAYALADKNLDADEISCVVQVLEEALKC-P 731
Cdd:COG5010    6 GFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLdP 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186532568 732 SDGlrkgQALNNLGSIYINLGMLDQAETAYKNAIEIK--HTRARQGLARVYFLKNQRKEACEEMTKLIEKS 800
Cdd:COG5010   86 NNP----ELYYNLALLYSRSGDKDEAKEYYEKALALSpdNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 205-299 1.49e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 47.34  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 205 EVSDISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEI---DFSENgiSIEAMLALnIYSRIKRvdlFRVETVF 281
Cdd:cd18314    5 EFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVtleDVEPE--IFETVLKY-MYTGQVT---LSEENVL 78

                         90
                 ....*....|....*...
gi 186532568 282 ELLQLASKFCCDDLKSEC 299
Cdd:cd18314   79 DLLMLASKYQVPDLEKLC 96
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 207-300 1.76e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 47.23  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 207 SDISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEIDFSenGISIEAMLALNIYSRIKRVDLFRVETVFELLQL 286
Cdd:cd18300   10 SDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELP--GVSKETFLALLEYLYTDQAPILEDGDCVGLIVL 87

                         90
                 ....*....|....
gi 186532568 287 ASKFCCDDLKSECE 300
Cdd:cd18300   88 ANRLCLPRLVALCE 101
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 782-899 1.26e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 48.83  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568  782 LKNQRKEACEEMTKLIEKSCSK-------AAAYEKRSEY-C---EREKAKEDLDMATTLDPLRTYPYRYRAAVLMDDQRE 850
Cdd:TIGR00990 302 PESKADESYEEAARAFEKALDLgklgekeAIALNLRGTFkClkgKHLEALADLSKSIELDPRVTQSYIKRASMNLELGDP 381

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 186532568  851 TEAVEELSKAIAFRPELQTLHL-RAAFHEATGNLSLATQDCEAALCLDPN 899
Cdd:TIGR00990 382 DKAEEDFDKALKLNSEDPDIYYhRAQLHFIKGEFAQAGKDYQKSIDLDPD 431
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
747-868 1.44e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 44.39  E-value: 1.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 747 IYINLGMLDQAETAYKNAIEI--KHTRARQGLARVYFLKNQRKEAceemtkliekscskaaayekrseycerekakEDLD 824
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELdpDNADALNNLGLLLLEQGRYDEA-------------------------------IALE 49

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 186532568 825 MATTLDPLRTYPYRYRAAVLMDDQRETEAVEELSKAIAFRPELQ 868
Cdd:COG3063   50 KALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPSAL 93
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 204-297 1.93e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 44.94  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 204 DEVSDISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEIdfSENGISIEAMLAL--NIYSRIkrVDLFRVETVF 281
Cdd:cd18286   15 GEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEI--TLTGVSHAAVSFVllFIYGGV--LDLPDDVNLG 90

                         90
                 ....*....|....*.
gi 186532568 282 ELLQLASKFCCDDLKS 297
Cdd:cd18286   91 ELLSLADMYGLDGLKD 106
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
491-570 2.26e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.83  E-value: 2.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 491 LKDLATATELDPTLSFPYKYRAVMKFEQKQIKEAFQEIDRLIQfkLSPECLE---LRAWLYLATGDRESCLRDLRAVLSL 567
Cdd:COG4785   93 IADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALE--LDPDYAYaylNRGIALYYLGRYELAIADLEKALEL 170


                 ...
gi 186532568 568 EPN 570
Cdd:COG4785  171 DPN 173
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 579-781 3.48e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 47.68  E-value: 3.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 579 RDDLVEALTAQCIEVESEADCWVRLFDRW--SAVDDVASLAVVHQMLQNDPSKNFLRFRQSLLLLRLNCQGAAMRCLRMA 656
Cdd:COG3914   59 LLALAAGEAAAAAAALLLLAALLELAALLlqALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRA 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 657 WNLATSEAERLVYEGWLLYDMGYVEETLTKAEEAISIQRSFEAfflkayaladknldadeiscvvqvleealkcpsdglr 736
Cdd:COG3914  139 LALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAE------------------------------------- 181

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 186532568 737 kgqALNNLGSIYINLGMLDQAETAYKNAIEIK--HTRARQGLARVYF 781
Cdd:COG3914  182 ---ALNNLGNALQDLGRLEEAIAAYRRALELDpdNADAHSNLLFALR 225
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 633-768 5.12e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.03  E-value: 5.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 633 RFRQSLLLLRLNCQGAAMRCLRMAWNLATSEAERLVYEGWLLYDMGYVEETLTKAEEAISIQ-RSFEAFFLKAYALADKN 711
Cdd:COG4783    7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDpDEPEARLNLGLALLKAG 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 186532568 712 LDADEIscvvQVLEEALK-CPSDglrkGQALNNLGSIYINLGMLDQAETAYKNAIEIK 768
Cdd:COG4783   87 DYDEAL----ALLEKALKlDPEH----PEAYLRLARAYRALGRPDEAIAALEKALELD 136
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 721-799 7.51e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 43.06  E-value: 7.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 721 VQVLEEALKCPSDGLRKGQALNNLGSIYINLGMLDQAETAYKNAIE-----IKHTRARQGLARVYFLKNQRKEACEEMTK 795
Cdd:COG1729   13 IAAFKAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKrypdsPKAPDALLKLGLSYLELGDYDKARATLEE 92


                 ....
gi 186532568 796 LIEK 799
Cdd:COG1729   93 LIKK 96
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
763-918 1.09e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 44.52  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 763 NAIEIKHTRARQGLARVYFLKNQRKEACEEMTKLIEKSCSKAAAYEKRSEYCEREKAKEDLDMATTLDPLRTYPYRYRAA 842
Cdd:COG4785    2 YALALALLLALALAAAAASKAAILLAALLFAAVLALAIALADLALALAAAALAAAALAAERIDRALALPDLAQLYYERGV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 843 VLMDDQRETEAVEELSKAIAFRPEL-QTLHLRAAFHEATGNLSLATQDCEAALCLDPNHTETLH-----LYSRSKDQASS 916
Cdd:COG4785   82 AYDSLGDYDLAIADFDQALELDPDLaEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLnrgiaLYYLGRYELAI 161


                 ..
gi 186532568 917 ID 918
Cdd:COG4785  162 AD 163
TPR_1 pfam00515
Tetratricopeptide repeat;
739-770 1.62e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.71  E-value: 1.62e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 186532568  739 QALNNLGSIYINLGMLDQAETAYKNAIEIKHT 770
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 687-833 1.83e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.03  E-value: 1.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 687 AEEAISIQRSFEAFFLKAYALADKNLDADEISCVVQVLEEALKCPSDGLRKGQALNNLGSIYINLGMLDQAETAYKNAIE 766
Cdd:COG5010    3 ALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQ 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186532568 767 I--KHTRARQGLARVYFLKNQRKEACEEMTKLIEKSCSKAAAYEKRSEYCER----EKAKEDLDMATTLDPLR 833
Cdd:COG5010   83 LdpNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSlgqdDEAKAALQRALGTSPLK 155
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 207-299 2.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 42.28  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 207 SDISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEIDFsENGISIEAMLALNIYSRIKRVdLFRVETVFELLQL 286
Cdd:cd18267   41 TDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNF-HDSIHPEVLELLLDYAYSSRV-IINEENAESLLEA 118

                         90
                 ....*....|...
gi 186532568 287 ASKFCCDDLKSEC 299
Cdd:cd18267  119 GDMLEFQDIRDAC 131
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
499-764 5.11e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.69  E-value: 5.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 499 ELDPTLSFPYKYRAVMKFEQKQIKEAFQEIDRLIQFK-LSPECLELRAWLYLATGDRESCLRDLRAVLSLEPNYvvfggk 577
Cdd:COG0457    2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDpDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD------ 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 578 mrddlVEALTAQcieveseADCWVRLFDRWSAvddvasLAVVHQMLQNDPSKNFLRFRQSLLLLRLNCQGAAMRCLRMAW 657
Cdd:COG0457   76 -----AEALNNL-------GLALQALGRYEEA------LEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERAL 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 658 NLATSEAERLVYEGWLLYDMGYVEETLTKAEEAISIQRSFEAFFLKAYALADKNLDADEISCVVQVLEEALKCPSDGLRK 737
Cdd:COG0457  138 ELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLA 217

                        250       260
                 ....*....|....*....|....*..
gi 186532568 738 GQALNNLGSIYINLGMLDQAETAYKNA 764
Cdd:COG0457  218 ALAELLLLALALLLALRLAALALYQYR 244
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 739-767 5.32e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 38.20  E-value: 5.32e-04
                           10        20
                   ....*....|....*....|....*....
gi 186532568   739 QALNNLGSIYINLGMLDQAETAYKNAIEI 767
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALEL 30
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 805-898 5.51e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.48  E-value: 5.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 805 AAYEKRSEYcerEKAKEDLDMATTLDPLRTYPYRYRAAVLMDDQRETEAVEELSKAIAFRPELQTLHL-RAAFHEATGNL 883
Cdd:COG5010   62 NLYNKLGDF---EESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSnLAALLLSLGQD 138

                         90
                 ....*....|....*
gi 186532568 884 SLATQDCEAALCLDP 898
Cdd:COG5010  139 DEAKAALQRALGTSP 153
TPR_8 pfam13181
Tetratricopeptide repeat;
739-768 5.90e-04

Tetratricopeptide repeat;


Pssm-ID: 404131 [Multi-domain]  Cd Length: 33  Bit Score: 38.15  E-value: 5.90e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 186532568  739 QALNNLGSIYINLGMLDQAETAYKNAIEIK 768
Cdd:pfam13181   2 EAYYNLGLIYLKLGDYEEAKEYYEKALELD 31
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 205-311 6.29e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 40.33  E-value: 6.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 205 EVSDISFCVgsEKAKCVRSRI--AALSRPFEAMLYGSFVESTTSEIDFSENGISIEAMLALNIYSRIKRVDLFRVETVFE 282
Cdd:cd18297   11 EMSDVTFLV--EGRPFYAHKIvlVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLDVAQDDALE 88

                         90       100
                 ....*....|....*....|....*....
gi 186532568 283 LLQLASKFCCDDLKSECEARLAASVtDLD 311
Cdd:cd18297   89 LLRAASFFQLDGLKRHCEILLSQQI-DLD 116
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 491-571 8.29e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.56  E-value: 8.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 491 LKDLATATELDPTLSFPYKYRAVMKFEQKQIKEAFQEIDRLIqfKLSPECLELR---AWLYLATGDRESCLRDLRAVLSL 567
Cdd:COG4783   24 EALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEAL--ELDPDEPEARlnlGLALLKAGDYDEALALLEKALKL 101


                 ....
gi 186532568 568 EPNY 571
Cdd:COG4783  102 DPEH 105
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 204-301 8.42e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 39.92  E-value: 8.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 204 DEVSDISFCVGSEKA--KCVRSRIAALSRPFEAMLYGSFV-ESTTSEIDFSEngISIEAMLAL--NIYS-RIKrvdlFRV 277
Cdd:cd18294   12 PEFSDVKFLVGPERQeiFAHKCILAARCEVFRAMFLTGPQkESTQSPLVLSD--IEPEVFRAVleFIYTnCVT----LSN 85

                         90       100
                 ....*....|....*....|....
gi 186532568 278 ETVFELLQLASKFCCDDLKSECEA 301
Cdd:cd18294   86 HTVIEVLAAAVEYGLDELRKLCER 109
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 205-301 9.17e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 39.83  E-value: 9.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 205 EVSDISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEIDFseNGISIEAMLALNIYSRIKRVDLFRvETVFELL 284
Cdd:cd18257   17 ELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEF--QCIDETALQAIVEYAYTGTVFISQ-ATVESLL 93

                         90       100
                 ....*....|....*....|....*
gi 186532568 285 QLAS--------KFCCDDLKSECEA 301
Cdd:cd18257   94 PAANllqiklvlKECCDFLESQLDP 118
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
481-572 1.54e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.05  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 481 RSLYNVGVEKLKDLATATELDPTLSFP-----YKYRAVMKFEQKQIKEAFQEIDRLIQFK-LSPECLELRAWLYLATGDR 554
Cdd:COG4785   44 LALALAAAALAAAALAAERIDRALALPdlaqlYYERGVAYDSLGDYDLAIADFDQALELDpDLAEAYNNRGLAYLLLGDY 123

                         90
                 ....*....|....*...
gi 186532568 555 ESCLRDLRAVLSLEPNYV 572
Cdd:COG4785  124 DAALEDFDRALELDPDYA 141
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 478-626 2.25e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 2.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 478 YQERSLYNVGVEKLKDLAtatELDPTLSFPYKYRAVMKFEQKQIKEAFQEIDRLIqfKLSPECLE---LRAWLYLATGDR 554
Cdd:COG2956  120 YEQEGDWEKAIEVLERLL---KLGPENAHAYCELAELYLEQGDYDEAIEALEKAL--KLDPDCARallLLAELYLEQGDY 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 555 ESCLRDLRAVLSLEPNYVVFGGKM------RDDLVEALTA--QCIEVESEADCWVRLFDRWSAVDDV-ASLAVVHQMLQN 625
Cdd:COG2956  195 EEAIAALERALEQDPDYLPALPRLaelyekLGDPEEALELlrKALELDPSDDLLLALADLLERKEGLeAALALLERQLRR 274


                 .
gi 186532568 626 D 626
Cdd:COG2956  275 H 275
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 208-307 3.66e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 38.43  E-value: 3.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 208 DISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTT--SEID-FSENGISIEAMLALNIYSRIKRVDLfRVETVFELL 284
Cdd:cd18296   19 DVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEEnnGSIPvVTLHDVSPEVFAIVLYYIYTDDTDL-PPENAYDVL 97

                         90       100
                 ....*....|....*....|...
gi 186532568 285 QLASKFCCDDLKSECEARLAASV 307
Cdd:cd18296   98 YVADMYLLPGLKRLCGTVLAQSL 120
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
491-572 3.79e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 3.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 491 LKDLATATELDPTLSFPYKYRAVMKFEQKQIKEAFQEIDRLIQFK-LSPECLELRAWLYLATGDRESCLRDLRAVLSLEP 569
Cdd:COG0457   62 LADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDpDDAEALYNLGLALLELGRYDEAIEAYERALELDP 141


                 ...
gi 186532568 570 NYV 572
Cdd:COG0457  142 DDA 144
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 207-253 4.93e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 38.07  E-value: 4.93e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 186532568 207 SDISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEIDFSEN 253
Cdd:cd18254   23 TDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDS 69
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 648-799 7.23e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.33  E-value: 7.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186532568 648 AAMRCLRMAWNLATSEAERLVYEGWLLYDMGYVEETLTKAEEAISIQRSF-EAFFLKAYALADKNlDADEiscVVQVLEE 726
Cdd:COG2956  128 KAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCaRALLLLAELYLEQG-DYEE---AIAALER 203

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186532568 727 ALKcpsDGLRKGQALNNLGSIYINLGMLDQAETAYKNAIEIKH-TRARQGLARVYFLKNQRKEACEEMTKLIEK 799
Cdd:COG2956  204 ALE---QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPsDDLLLALADLLERKEGLEAALALLERQLRR 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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