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Conserved domains on  [gi|15237721|ref|NP_200670|]
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zinc finger (CCCH-type) family protein [Arabidopsis thaliana]

Protein Classification

zinc finger CCCH domain-containing protein( domain architecture ID 12122282)

zinc finger CCCH domain-containing protein similar to Arabidopsis CCCH-containing zinc-finger proteins that possess nuclease activity; also contains ankyrin repeats

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
59-165 5.41e-11

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.82  E-value: 5.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237721  59 RTPLMIAALFGSKEVVDYIISTGlVDVNRScGSDGATALHCAVsglSANSLEIVTLLLKGSANPDSCDAYGNkpgdvifp 138
Cdd:COG0666 121 ETPLHLAAYNGNLEIVKLLLEAG-ADVNAQ-DNDGNTPLHLAA---ANGNLEIVKLLLEAGADVNARDNDGE-------- 187

                        90       100       110
                ....*....|....*....|....*....|.
gi 15237721 139 clSPVFSARMK----VLERLLKGNDDLNEVN 165
Cdd:COG0666 188 --TPLHLAAENghleIVKLLLEAGADVNAKD 216
ZnF_C3H1 smart00356
zinc finger;
250-274 1.75e-05

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 41.85  E-value: 1.75e-05
                           10        20
                   ....*....|....*....|....*
gi 15237721    250 YSCVPCPEFRKGSCSRGDTCEYAHG 274
Cdd:smart00356   2 YKTELCKFFKRGYCPRGDRCKFAHP 26
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
59-165 5.41e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.82  E-value: 5.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237721  59 RTPLMIAALFGSKEVVDYIISTGlVDVNRScGSDGATALHCAVsglSANSLEIVTLLLKGSANPDSCDAYGNkpgdvifp 138
Cdd:COG0666 121 ETPLHLAAYNGNLEIVKLLLEAG-ADVNAQ-DNDGNTPLHLAA---ANGNLEIVKLLLEAGADVNARDNDGE-------- 187

                        90       100       110
                ....*....|....*....|....*....|.
gi 15237721 139 clSPVFSARMK----VLERLLKGNDDLNEVN 165
Cdd:COG0666 188 --TPLHLAAENghleIVKLLLEAGADVNAKD 216
Ank_2 pfam12796
Ankyrin repeats (3 copies);
57-124 5.83e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.28  E-value: 5.83e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15237721    57 EERTPLMIAALFGSKEVVDYIISTGLVDVNrscgSDGATALHCAVsglSANSLEIVTLLLKGSANPDS 124
Cdd:pfam12796  29 NGRTALHLAAKNGHLEIVKLLLEHADVNLK----DNGRTALHYAA---RSGHLEIVKLLLEKGADINV 89
PHA03095 PHA03095
ankyrin-like protein; Provisional
 71-165 1.06e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.10  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237721   71 KEVVDYIISTGlVDVNR--SCGsdgATALHCAVsgLSANSLEIVTLLLKGSANPDSCDAYGNKPgdvIFPCLSpVFSARM 148
Cdd:PHA03095  63 KDIVRLLLEAG-ADVNApeRCG---FTPLHLYL--YNATTLDVIKLLIKAGADVNAKDKVGRTP---LHVYLS-GFNINP 132

                         90
                 ....*....|....*..
gi 15237721  149 KVLERLLKGNDDLNEVN 165
Cdd:PHA03095 133 KVIRLLLRKGADVNALD 149
ZnF_C3H1 smart00356
zinc finger;
250-274 1.75e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 41.85  E-value: 1.75e-05
                           10        20
                   ....*....|....*....|....*
gi 15237721    250 YSCVPCPEFRKGSCSRGDTCEYAHG 274
Cdd:smart00356   2 YKTELCKFFKRGYCPRGDRCKFAHP 26
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
253-274 6.81e-04

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 37.17  E-value: 6.81e-04
                          10        20
                  ....*....|....*....|...
gi 15237721   253 VPCPEFRK-GSCSRGDTCEYAHG 274
Cdd:pfam00642   4 ELCRFFLRtGYCKYGDRCKFAHG 26
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
59-165 5.41e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.82  E-value: 5.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237721  59 RTPLMIAALFGSKEVVDYIISTGlVDVNRScGSDGATALHCAVsglSANSLEIVTLLLKGSANPDSCDAYGNkpgdvifp 138
Cdd:COG0666 121 ETPLHLAAYNGNLEIVKLLLEAG-ADVNAQ-DNDGNTPLHLAA---ANGNLEIVKLLLEAGADVNARDNDGE-------- 187

                        90       100       110
                ....*....|....*....|....*....|.
gi 15237721 139 clSPVFSARMK----VLERLLKGNDDLNEVN 165
Cdd:COG0666 188 --TPLHLAAENghleIVKLLLEAGADVNAKD 216
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
59-132 1.36e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.66  E-value: 1.36e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15237721  59 RTPLMIAALFGSKEVVDYIISTGlVDVNRScGSDGATALHCAVSGlsaNSLEIVTLLLKGSANPDSCDAYGNKP 132
Cdd:COG0666 154 NTPLHLAAANGNLEIVKLLLEAG-ADVNAR-DNDGETPLHLAAEN---GHLEIVKLLLEAGADVNAKDNDGKTA 222
Ank_2 pfam12796
Ankyrin repeats (3 copies);
57-124 5.83e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.28  E-value: 5.83e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15237721    57 EERTPLMIAALFGSKEVVDYIISTGLVDVNrscgSDGATALHCAVsglSANSLEIVTLLLKGSANPDS 124
Cdd:pfam12796  29 NGRTALHLAAKNGHLEIVKLLLEHADVNLK----DNGRTALHYAA---RSGHLEIVKLLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
57-167 6.87e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.35  E-value: 6.87e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237721  57 EERTPLMIAALFGSKEVVDYIISTGlVDVNrSCGSDGATALHCAVsglSANSLEIVTLLLKGSANPDSCDAYGNkpgdvi 136
Cdd:COG0666  86 GGNTLLHAAARNGDLEIVKLLLEAG-ADVN-ARDKDGETPLHLAA---YNGNLEIVKLLLEAGADVNAQDNDGN------ 154

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15237721 137 fpclSPVFSA----RMKVLERLLKGNDDLNEVNGQ 167
Cdd:COG0666 155 ----TPLHLAaangNLEIVKLLLEAGADVNARDND 185
Ank_4 pfam13637
Ankyrin repeats (many copies);
58-116 2.76e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 2.76e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15237721    58 ERTPLMIAALFGSKEVVDYIISTGlVDVNRSCGsDGATALHCAVSGlsaNSLEIVTLLL 116
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKG-ADINAVDG-NGETALHFAASN---GNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
62-132 9.14e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.03  E-value: 9.14e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15237721    62 LMIAALFGSKEVVDYIISTGlVDVNrSCGSDGATALHCAVSGlsaNSLEIVTLLLKgSANPDSCDaYGNKP 132
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADAN-LQDKNGRTALHLAAKN---GHLEIVKLLLE-HADVNLKD-NGRTA 64
PHA03095 PHA03095
ankyrin-like protein; Provisional
 71-165 1.06e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.10  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237721   71 KEVVDYIISTGlVDVNR--SCGsdgATALHCAVsgLSANSLEIVTLLLKGSANPDSCDAYGNKPgdvIFPCLSpVFSARM 148
Cdd:PHA03095  63 KDIVRLLLEAG-ADVNApeRCG---FTPLHLYL--YNATTLDVIKLLIKAGADVNAKDKVGRTP---LHVYLS-GFNINP 132

                         90
                 ....*....|....*..
gi 15237721  149 KVLERLLKGNDDLNEVN 165
Cdd:PHA03095 133 KVIRLLLRKGADVNALD 149
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
57-163 1.10e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 47.64  E-value: 1.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237721  57 EERTPLMIAALFGSKEVVDYIISTGlVDVNRScGSDGATALHCAVsglSANSLEIVTLLLKGSANPDSCDAYGNKPGDVI 136
Cdd:COG0666 185 DGETPLHLAAENGHLEIVKLLLEAG-ADVNAK-DNDGKTALDLAA---ENGNLEIVKLLLEAGADLNAKDKDGLTALLLA 259

                        90       100
                ....*....|....*....|....*..
gi 15237721 137 FPCLSPVFSARMKVLERLLKGNDDLNE 163
Cdd:COG0666 260 AAAGAALIVKLLLLALLLLAAALLDLL 286
ZnF_C3H1 smart00356
zinc finger;
250-274 1.75e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 41.85  E-value: 1.75e-05
                           10        20
                   ....*....|....*....|....*
gi 15237721    250 YSCVPCPEFRKGSCSRGDTCEYAHG 274
Cdd:smart00356   2 YKTELCKFFKRGYCPRGDRCKFAHP 26
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 92-126 3.84e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.74  E-value: 3.84e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15237721    92 DGATALHCAVSglSANSLEIVTLLLKGSANPDSCD 126
Cdd:pfam00023   1 DGNTPLHLAAG--RRGNLEIVKLLLSKGADVNARD 33
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
253-274 6.81e-04

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 37.17  E-value: 6.81e-04
                          10        20
                  ....*....|....*....|...
gi 15237721   253 VPCPEFRK-GSCSRGDTCEYAHG 274
Cdd:pfam00642   4 ELCRFFLRtGYCKYGDRCKFAHG 26
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
60-165 1.03e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.48  E-value: 1.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237721  60 TPLMIAALFGSKEVVDYIISTGLVDVNRScGSDGATALHCAVSGlsaNSLEIVTLLLKGSANPDSCDAYGNKPGDVIfpc 139
Cdd:COG0666  55 ALLLLAAALAGDLLVALLLLAAGADINAK-DDGGNTLLHAAARN---GDLEIVKLLLEAGADVNARDKDGETPLHLA--- 127

                        90       100
                ....*....|....*....|....*.
gi 15237721 140 lspVFSARMKVLERLLKGNDDLNEVN 165
Cdd:COG0666 128 ---AYNGNLEIVKLLLEAGADVNAQD 150
PHA03095 PHA03095
ankyrin-like protein; Provisional
 60-135 1.44e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.55  E-value: 1.44e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15237721   60 TPLMIAALFGSKE-VVDYIISTGlVDVNRSCGSdGATALHCAVSGLSANSlEIVTLLLKGSANPDSCDAYGNKPGDV 135
Cdd:PHA03095  85 TPLHLYLYNATTLdVIKLLIKAG-ADVNAKDKV-GRTPLHVYLSGFNINP-KVIRLLLRKGADVNALDLYGMTPLAV 158
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 253-273 1.69e-03

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 36.03  E-value: 1.69e-03
                          10        20
                  ....*....|....*....|.
gi 15237721   253 VPCPEFRKGSCSRGDTCEYAH 273
Cdd:pfam18044   1 RLCRYFQKGGCRYGDNCRFSH 21
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 255-273 2.76e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 35.47  E-value: 2.76e-03
                          10
                  ....*....|....*....
gi 15237721   255 CPEFRKGSCSRGDTCEYAH 273
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 71-141 5.20e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 39.65  E-value: 5.20e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15237721   71 KEVVDYIISTGL-VDVNRSCGSdgaTALHCAVSglsANSLEIVTLLLKGSANPDSCDAYGNKPgdVIFPCLS 141
Cdd:PHA03100 172 KNRVNYLLSYGVpINIKDVYGF---TPLHYAVY---NNNPEFVKYLLDLGANPNLVNKYGDTP--LHIAILN 235
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 59-86 8.46e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.16  E-value: 8.46e-03
                          10        20
                  ....*....|....*....|....*...
gi 15237721    59 RTPLMIAALFGSKEVVDYIISTGlVDVN 86
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENG-ADIN 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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