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Conserved domains on  [gi|15595243|ref|NP_248735|]
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hypothetical protein PA0045 [Pseudomonas aeruginosa PAO1]

Protein Classification

CsgG/HfaB family protein( domain architecture ID 10003703)

CsgG/HfaB family protein similar to Caulobacter HfaB, which is involved in attachment of the holdfast, a polysaccharide complex adhesive organelle, to the cell, and to CsgG, a lipoprotein that forms a secretion channel for curli subunits, functional amyloids involved in biofilm formation, in the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CsgG COG1462
Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope ...
 1-228 3.17e-77

Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 441071 [Multi-domain]  Cd Length: 263  Bit Score: 233.37  E-value: 3.17e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243   1 MSHSAKKALLPLLAVATLAGLAgcATETSTALPVQQVESVNR----------PYSGVRSPIAVGKFDNRSSYMRgifSDG 70
Cdd:COG1462   1 MKKSILALLLLALLALLLAGCA--TTESSTPVEVEPPVLANAtpyaqdlvalPYPGPKPRVAVGDFDDQTGQNG---SSG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243  71 VDRLGGQAKTILITHLQQTNRFNVLDRDNMSEIQQEAAIKG----------QAQRLKGADYVVTGDVTEFGRKEVGDRQ- 139
Cdd:COG1462  76 SDAVGQGASDMLITALQQSGRFTVVERENLSNLLAERKLAGsgriragtaaQLGQLLGADYLITGGITEFDRNTSGGGGg 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243 140 --LFGILGRGKSQIAYAKVALNIVNISTSEVVYSTQGAGEYALSNREVIGFG---------GTASYDSTLNGKVLDLAMR 208
Cdd:COG1462 156 arLFGIGGSGKYQVAYVTVDLRLVDVRTGEVVYSVTGSGEISSSEVSAGGFGfvggglleaGTGGYDNTPNGKAVRAAIE 235

                       250       260
                ....*....|....*....|
gi 15595243 209 EAVNKLVNAVDSGAWKPQNQ 228
Cdd:COG1462 236 EAVNNLVAGLEAGAWRPADL 255
 
Name Accession Description Interval E-value
CsgG COG1462
Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope ...
 1-228 3.17e-77

Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441071 [Multi-domain]  Cd Length: 263  Bit Score: 233.37  E-value: 3.17e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243   1 MSHSAKKALLPLLAVATLAGLAgcATETSTALPVQQVESVNR----------PYSGVRSPIAVGKFDNRSSYMRgifSDG 70
Cdd:COG1462   1 MKKSILALLLLALLALLLAGCA--TTESSTPVEVEPPVLANAtpyaqdlvalPYPGPKPRVAVGDFDDQTGQNG---SSG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243  71 VDRLGGQAKTILITHLQQTNRFNVLDRDNMSEIQQEAAIKG----------QAQRLKGADYVVTGDVTEFGRKEVGDRQ- 139
Cdd:COG1462  76 SDAVGQGASDMLITALQQSGRFTVVERENLSNLLAERKLAGsgriragtaaQLGQLLGADYLITGGITEFDRNTSGGGGg 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243 140 --LFGILGRGKSQIAYAKVALNIVNISTSEVVYSTQGAGEYALSNREVIGFG---------GTASYDSTLNGKVLDLAMR 208
Cdd:COG1462 156 arLFGIGGSGKYQVAYVTVDLRLVDVRTGEVVYSVTGSGEISSSEVSAGGFGfvggglleaGTGGYDNTPNGKAVRAAIE 235

                       250       260
                ....*....|....*....|
gi 15595243 209 EAVNKLVNAVDSGAWKPQNQ 228
Cdd:COG1462 236 EAVNNLVAGLEAGAWRPADL 255
CsgG pfam03783
Curli production assembly/transport component CsgG; CsgG is an outer membrane-located ...
 48-226 1.06e-18

Curli production assembly/transport component CsgG; CsgG is an outer membrane-located lipoprotein that is highly resistant to protease digestion. During curli assembly, an adhesive surface fibre, CsgG is required to maintain the stability of CsgA and CsgB.


Pssm-ID: 427502  Cd Length: 209  Bit Score: 80.91  E-value: 1.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243    48 RSPIAVGKFDNRSS-YMRGIFSDGVDRLGGQAKTILITHLQQTNRFNVLDRDNMSEIQQEAAI----------KGQAQRL 116
Cdd:pfam03783   8 KIRIAVYDFSNQTGqYKPQPNSSFSTAVGQGLSDMLVQALVKSGWFRVLEREGLQNLLTEQKLgrsgridpntAAQLGKL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243   117 KGADYVVTGDVTEFG---RKEVGDRQLFGILGRGKSQIAYAKVALNIVNISTSEVVYSTQGAG-----EYALSNREVIGF 188
Cdd:pfam03783  88 TGADYLVEGSITAYDtnvSTGGGGARYLGIGASSKYREAQVAVDLRLVDVRTGEVLASVTGTGtssssEARAGVFRFIGK 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 15595243   189 GGTASYDSTLNGKVLDLAMREAVNK----LVNAVDSGAWKPQ 226
Cdd:pfam03783 168 GLLGGEAGSTSNEPVGLAVRAAIEQavkyLITGIERGAWLPQ 209
 
Name Accession Description Interval E-value
CsgG COG1462
Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope ...
 1-228 3.17e-77

Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441071 [Multi-domain]  Cd Length: 263  Bit Score: 233.37  E-value: 3.17e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243   1 MSHSAKKALLPLLAVATLAGLAgcATETSTALPVQQVESVNR----------PYSGVRSPIAVGKFDNRSSYMRgifSDG 70
Cdd:COG1462   1 MKKSILALLLLALLALLLAGCA--TTESSTPVEVEPPVLANAtpyaqdlvalPYPGPKPRVAVGDFDDQTGQNG---SSG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243  71 VDRLGGQAKTILITHLQQTNRFNVLDRDNMSEIQQEAAIKG----------QAQRLKGADYVVTGDVTEFGRKEVGDRQ- 139
Cdd:COG1462  76 SDAVGQGASDMLITALQQSGRFTVVERENLSNLLAERKLAGsgriragtaaQLGQLLGADYLITGGITEFDRNTSGGGGg 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243 140 --LFGILGRGKSQIAYAKVALNIVNISTSEVVYSTQGAGEYALSNREVIGFG---------GTASYDSTLNGKVLDLAMR 208
Cdd:COG1462 156 arLFGIGGSGKYQVAYVTVDLRLVDVRTGEVVYSVTGSGEISSSEVSAGGFGfvggglleaGTGGYDNTPNGKAVRAAIE 235

                       250       260
                ....*....|....*....|
gi 15595243 209 EAVNKLVNAVDSGAWKPQNQ 228
Cdd:COG1462 236 EAVNNLVAGLEAGAWRPADL 255
CsgG pfam03783
Curli production assembly/transport component CsgG; CsgG is an outer membrane-located ...
 48-226 1.06e-18

Curli production assembly/transport component CsgG; CsgG is an outer membrane-located lipoprotein that is highly resistant to protease digestion. During curli assembly, an adhesive surface fibre, CsgG is required to maintain the stability of CsgA and CsgB.


Pssm-ID: 427502  Cd Length: 209  Bit Score: 80.91  E-value: 1.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243    48 RSPIAVGKFDNRSS-YMRGIFSDGVDRLGGQAKTILITHLQQTNRFNVLDRDNMSEIQQEAAI----------KGQAQRL 116
Cdd:pfam03783   8 KIRIAVYDFSNQTGqYKPQPNSSFSTAVGQGLSDMLVQALVKSGWFRVLEREGLQNLLTEQKLgrsgridpntAAQLGKL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243   117 KGADYVVTGDVTEFG---RKEVGDRQLFGILGRGKSQIAYAKVALNIVNISTSEVVYSTQGAG-----EYALSNREVIGF 188
Cdd:pfam03783  88 TGADYLVEGSITAYDtnvSTGGGGARYLGIGASSKYREAQVAVDLRLVDVRTGEVLASVTGTGtssssEARAGVFRFIGK 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 15595243   189 GGTASYDSTLNGKVLDLAMREAVNK----LVNAVDSGAWKPQ 226
Cdd:pfam03783 168 GLLGGEAGSTSNEPVGLAVRAAIEQavkyLITGIERGAWLPQ 209
LpoB COG3417
Outer membrane lipoprotein LpoB, binds and activates PBP1b [Cell wall/membrane/envelope ...
 7-175 3.51e-07

Outer membrane lipoprotein LpoB, binds and activates PBP1b [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442643  Cd Length: 190  Bit Score: 48.77  E-value: 3.51e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243   7 KALLPLLAVATLAGLAGCATETSTALPVQQVESVnrpysgvrsPIAVGKFDNRSS---YMRGIF-SDGVDRLGGQAKTIL 82
Cdd:COG3417   2 KKKKLLLVALAALLLAGCASTPVTYVDPNEVEDV---------SGKWNSTDWQAAaepMVDSMLsSPWVAKTAGGRPVLL 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243  83 I------TH---------------LQQTNRFNVLDRDNMSEIQQE------------AAIKGQAqRLKGADYVVTGDVTe 129
Cdd:COG3417  73 VdsvknkTNehidtetatkdirraLINSGKFRFVSAGQLAQARQElglqrddslvsrSTAIGLG-REVGADYVLYGSIS- 150

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 15595243 130 fgrkevGDRQLfgilgRGKSQIAYAKVALNIVNISTSEVVYSTQGA 175
Cdd:COG3417 151 ------SIVDS-----PGKGKVVYYQFTLQLMDVQTGEIVWSGEKE 185
LpoB pfam13036
Peptidoglycan-synthase activator LpoB; This is a family of Gram-negative bacterial outer ...
 46-175 1.43e-03

Peptidoglycan-synthase activator LpoB; This is a family of Gram-negative bacterial outer membrane lipoproteins. LpoB is required for the function of the major peptidoglycan synthase enzyme PBP1B. It interacts with PBP1B protein via the UvrB-like non-catalytic domain on that protein. LpoB has a 54-aa-long flexible N-terminal stretch followed by a globular domain with similarity to the N-terminal domain of the prevalent periplasmic protein TolB. The long, flexible N-terminal region of LpoB enables it to span the periplasm and reach its docking site in PBP1B. Peptidoglycan is the essential polymer within the sacculus that surrounds the cytoplasmic membrane of bacteria.


Pssm-ID: 463777  Cd Length: 147  Bit Score: 37.67  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243    46 GVRSPIAVGKFDNRSSymrgifsdgvdrlgGQAKTILIT-----HLQQTNRFNVLDRDNMSEIQQE------------AA 108
Cdd:pfam13036  27 GKRPVLLVSDVKNDTS--------------EHIDTESLTdkirrALIKSGKFRFVDGAQRQDAREElrlqqdsglvdqST 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15595243   109 IKGQAqRLKGADYVVTGDVTEFGRKEvgdrqlfgilgrGKSQIAYAKVALNIVNISTSEVVYSTQGA 175
Cdd:pfam13036  93 AAKIG-RLIGADYSLSGKINSIVKAE------------GGEKVVYYQITLELTDVETGEIVWSGEKE 146
TolB_N pfam04052
TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent ...
 50-131 5.30e-03

TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent translocation system. This function of this amino terminal domain is uncertain.


Pssm-ID: 461148  Cd Length: 105  Bit Score: 35.29  E-value: 5.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243    50 PIAVGKFDnrssymrgifSDGVDRLGGQAKTILITHLQQTNRFNVLDRDNM-SEIQQEAAIKGQAQRLKGADYVVTGDVT 128
Cdd:pfam04052  14 PIAVVPFQ----------GEGGADLPQDISEVIAADLERSGLFRPIDPAAFpQRPTSDSEVDFADWRALGADALVTGSVT 83


                  ...
gi 15595243   129 EFG 131
Cdd:pfam04052  84 RGG 86
TolBN COG5616
TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];
51-131 9.73e-03

TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];


Pssm-ID: 444347  Cd Length: 135  Bit Score: 35.25  E-value: 9.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595243  51 IAVGKFDNRSS-YMRGIFSDGV--DrlggqaktiLITHLQQTNRFNVLDRDNMSEIQQEAA-IKGQAQRLkGADYVVTGD 126
Cdd:COG5616  13 IAVLPFENLSGdPEQEYFADGLteE---------LITALSRLRGLRVIARTSSFAFKGRAVdLREIAREL-GVRYVLEGS 82


                ....*
gi 15595243 127 VTEFG 131
Cdd:COG5616  83 VRRSG 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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