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Conserved domains on  [gi|15595534|ref|NP_249028|]
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phosphoenolpyruvate-protein phosphotransferase PtsP [Pseudomonas aeruginosa PAO1]

Protein Classification

3',5'-cyclic nucleotide phosphodiesterase; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; GAF domain-containing hybrid sensor histidine kinase/response regulator; GAF domain-containing protein; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; GAF domain-containing sensor histidine kinase; hybrid sensor histidine kinase/response regulator; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; GAF domain-containing protein; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; GAF domain-containing hybrid sensor histidine kinase/response regulator; GAF domain-containing protein; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; GAF domain-containing sensor histidine kinase; hybrid sensor histidine kinase/response regulator; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; GAF domain-containing protein; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; GAF domain-containing sensor histidine kinase; hybrid sensor histidine kinase/response regulator; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; GAF domain-containing protein; GAF domain-containing sensor histidine kinase; GGDEF domain-containing protein; GGDEF domain-containing protein; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; GGDEF domain-containing protein; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; sensor domain-containing diguanylate cyclase; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; GGDEF domain-containing protein; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; sensor domain-containing diguanylate cyclase; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; sensor domain-containing diguanylate cyclase; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; ATP-binding protein; sensor histidine kinase; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; ATP-binding protein; sensor histidine kinase; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; sensor histidine kinase; ATP-binding prote( domain architecture ID 11466476)

3',5'-cyclic nucleotide phosphodiesterase with one or more N-terminal GAF domains, may show activity towards 3',5'-cyclic GMP and/or 3',5'-cyclic AMP; GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; ATPase similar to histidine kinase domains; GAF domain-containing protein similar to Mycobacterium phage L5 Gene 84 protein; the GAF domain is a small-molecule-binding domain found in proteins including phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; ATPase similar to histidine kinase domains; GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase similar to Staphylococcus aureus VraS and Bacillus subtilis DesK; uncharacterized GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; two-component sensor histidine kinase similar to Staphylococcus aureus VraS and Bacillus subtilis DesK; ATPase similar to histidine kinase domains; GAF domain-containing protein similar to Mycobacterium phage L5 Gene 84 protein; the GAF domain is a small-molecule-binding domain found in proteins including phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; two-component sensor histidine kinase similar to Staphylococcus aureus VraS and Bacillus subtilis DesK; GAF domain-containing sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to external signals; contains one or more GAF sensor domain(s); ATPase similar to histidine kinase domains; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; uncharacterized GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; GAF domain-containing protein similar to Mycobacterium phage L5 Gene 84 protein; the GAF domain is a small-molecule-binding domain found in proteins including phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; two-component sensor histidine kinase containing a GAF sensor domain; may also contain a PAS sensor and/or ligand-binding domain; ATPase similar to histidine kinase domains; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; uncharacterized GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; GAF domain-containing protein similar to Mycobacterium phage L5 Gene 84 protein; the GAF domain is a small-molecule-binding domain found in proteins including phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; two-component sensor histidine kinase containing a GAF sensor domain; may also contain a PAS sensor and/or ligand-binding domain; two-component sensor histidine kinase with GAF and/or PAS sensor domain(s), functions as a protein kinase that phosphorylates a target protein in response to various signals; ATPase similar to histidine kinase domains; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; uncharacterized GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; GAF domain-containing protein similar to Mycobacterium phage L5 Gene 84 protein; the GAF domain is a small-molecule-binding domain found in proteins including phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; two-component sensor histidine kinase containing a GAF sensor domain; may also contain a PAS sensor and/or ligand-binding domain; ATPase similar to histidine kinase domains; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; uncharacterized GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; GAF domain-containing protein similar to Mycobacterium phage L5 Gene 84 protein; the GAF domain is a small-molecule-binding domain found in proteins including phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; two-component sensor histidine kinase containing a GAF sensor domain; may also contain a PAS sensor and/or ligand-binding domain; two-component sensor histidine kinase with GAF and/or PAS sensor domain(s), functions as a protein kinase that phosphorylates a target protein in response to various signals; GAF domain-containing protein similar to Mycobacterium phage L5 Gene 84 protein; the GAF domain is a small-molecule-binding domain found in proteins including phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; GAF domain-containing protein similar to Mycobact

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11061 super family cl32635
phosphoenolpyruvate--protein phosphotransferase;
1-751 0e+00

phosphoenolpyruvate--protein phosphotransferase;


The actual alignment was detected with superfamily member PRK11061:

Pssm-ID: 182937 [Multi-domain]  Cd Length: 748  Bit Score: 824.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534    1 MLNTLRKIVQEVNSAKDLKAALGIIVQRVKEAMGTQVCSVYLLDTETQRFVLMATEGLNKRSIGKVSMAPSEGLVGLVGT 80
Cdd:PRK11061   1 MLTRLREIVEKVASAPRLNEALDILVTETCLAMDTEVCSVYLADHDRRCYYLMATRGLKKPRGRTVTLAFDEGIVGLVGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   81 REEPLNLENAAAHPRYRYFAETGEERYASFLGAPIIHHRRVMGVLVVQQKERRQFDEGEEAFLVTMSAQLAGVIAHAEAT 160
Cdd:PRK11061  81 LAEPINLADAQKHPSFKYIPSVKEERFRAFLGVPIIYRRQLLGVLVVQQRELRQFDESEESFLVTLATQLAAILSQSQLT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  161 GSIRGLgklgkgiQEAKFVGVPGAPGVGVGKAVVVLPPADLEVVPDKQVDDIDAEIALFKQALEGVRADMRALSSKLASQ 240
Cdd:PRK11061 161 ALFGQY-------RQTRIRALPASPGVAIAEGWQDATQPLLEQVYPASTLDPALERERLTGALEEAANEFRRYSKRFAAG 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  241 LRKEERALFDVYLMMLDDASIGNEVKRIIRTGQWAQGALRQVVMEHVQRFELMDDAYLRERASDVKDIGRRLLAYLQEER 320
Cdd:PRK11061 234 AQKETAAIFDLYSHLLNDPRLRRELFAEVDKGSVAEWAVKQVIEKFAEQFAALSDNYLRERAGDLRALGQRLLFHLDDSE 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  321 KQNLTYPEQTIIVSEELSPAMLGEVPEGRLVGLVSVLGSGNSHVAILARAMGIPTVMGAvDLPYSKVDGIDLIVDGYHGE 400
Cdd:PRK11061 314 QGPNAWPERFILVADELTATLLAELPQDRLAGVVVRDGAANSHAAILVRALGIPTVMGA-DIQPSLLHQRLLIVDGYRGE 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  401 VYTNPSAELVRQYSDVVAEERELSKGLAALRELPCETLDGHRMPLWVNTGLLADVARAQERGAEGVGLYRTEVPFMINDR 480
Cdd:PRK11061 393 LLVDPEPVLLQEYQRLISEEIELSRLAEDDVNLPAQLKSGERIKVMLNAGLSAEHEEKLGSRVDGVGLYRTEIPFMLQSG 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  481 FPSEKEQLAIYREQLSAFHPLPVTMRTLDIGGDKALSYFPIKEDNPFLGWRGIRVTLDHPEIFLVQTRAMLKASEGLDNL 560
Cdd:PRK11061 473 FPSEEEQVAQYQGMLQMFPDKPVTLRTLDIGADKQLPYMPISEENPCLGWRGIRITLDQPEIFLIQVRAMLRANAATGNL 552

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  561 RILLPMISGTHELEEALHLIHRAWGEVRDE-GVDIAMPPIGMMVEIPAAVYQTRELARQVDFLSVGSNDLTQYLLAVDRN 639
Cdd:PRK11061 553 SILLPMVTSIDEVDEARRLIDRAGREVEEMlGYEIPKPRIGIMIEVPSMVFMLPHLASRVDFISVGTNDLTQYLLAVDRN 632

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  640 NPRVADLYDYLHPAVLHALKKVVDDAHLEGKPVSICGEMAGDPAAAVLLMAMGFDSLSMNATNLPKVKWLLRQITLDKAR 719
Cdd:PRK11061 633 NTRVASLYDSLHPAMLRALKMIADEAEQHGLPVSLCGEMAGDPMGALLLIGLGYRHLSMNGRSVARVKYLLRHIDLAEAE 712

                        730       740       750
                 ....*....|....*....|....*....|..
gi 15595534  720 DLLGQLLTFDNPQVIHSSLHLALRNLGLGRVI 751
Cdd:PRK11061 713 NLAQRSLEAQLATEVRHQVAAFMERRGLGGLI 744
 
Name Accession Description Interval E-value
PRK11061 PRK11061
phosphoenolpyruvate--protein phosphotransferase;
1-751 0e+00

phosphoenolpyruvate--protein phosphotransferase;


Pssm-ID: 182937 [Multi-domain]  Cd Length: 748  Bit Score: 824.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534    1 MLNTLRKIVQEVNSAKDLKAALGIIVQRVKEAMGTQVCSVYLLDTETQRFVLMATEGLNKRSIGKVSMAPSEGLVGLVGT 80
Cdd:PRK11061   1 MLTRLREIVEKVASAPRLNEALDILVTETCLAMDTEVCSVYLADHDRRCYYLMATRGLKKPRGRTVTLAFDEGIVGLVGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   81 REEPLNLENAAAHPRYRYFAETGEERYASFLGAPIIHHRRVMGVLVVQQKERRQFDEGEEAFLVTMSAQLAGVIAHAEAT 160
Cdd:PRK11061  81 LAEPINLADAQKHPSFKYIPSVKEERFRAFLGVPIIYRRQLLGVLVVQQRELRQFDESEESFLVTLATQLAAILSQSQLT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  161 GSIRGLgklgkgiQEAKFVGVPGAPGVGVGKAVVVLPPADLEVVPDKQVDDIDAEIALFKQALEGVRADMRALSSKLASQ 240
Cdd:PRK11061 161 ALFGQY-------RQTRIRALPASPGVAIAEGWQDATQPLLEQVYPASTLDPALERERLTGALEEAANEFRRYSKRFAAG 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  241 LRKEERALFDVYLMMLDDASIGNEVKRIIRTGQWAQGALRQVVMEHVQRFELMDDAYLRERASDVKDIGRRLLAYLQEER 320
Cdd:PRK11061 234 AQKETAAIFDLYSHLLNDPRLRRELFAEVDKGSVAEWAVKQVIEKFAEQFAALSDNYLRERAGDLRALGQRLLFHLDDSE 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  321 KQNLTYPEQTIIVSEELSPAMLGEVPEGRLVGLVSVLGSGNSHVAILARAMGIPTVMGAvDLPYSKVDGIDLIVDGYHGE 400
Cdd:PRK11061 314 QGPNAWPERFILVADELTATLLAELPQDRLAGVVVRDGAANSHAAILVRALGIPTVMGA-DIQPSLLHQRLLIVDGYRGE 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  401 VYTNPSAELVRQYSDVVAEERELSKGLAALRELPCETLDGHRMPLWVNTGLLADVARAQERGAEGVGLYRTEVPFMINDR 480
Cdd:PRK11061 393 LLVDPEPVLLQEYQRLISEEIELSRLAEDDVNLPAQLKSGERIKVMLNAGLSAEHEEKLGSRVDGVGLYRTEIPFMLQSG 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  481 FPSEKEQLAIYREQLSAFHPLPVTMRTLDIGGDKALSYFPIKEDNPFLGWRGIRVTLDHPEIFLVQTRAMLKASEGLDNL 560
Cdd:PRK11061 473 FPSEEEQVAQYQGMLQMFPDKPVTLRTLDIGADKQLPYMPISEENPCLGWRGIRITLDQPEIFLIQVRAMLRANAATGNL 552

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  561 RILLPMISGTHELEEALHLIHRAWGEVRDE-GVDIAMPPIGMMVEIPAAVYQTRELARQVDFLSVGSNDLTQYLLAVDRN 639
Cdd:PRK11061 553 SILLPMVTSIDEVDEARRLIDRAGREVEEMlGYEIPKPRIGIMIEVPSMVFMLPHLASRVDFISVGTNDLTQYLLAVDRN 632

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  640 NPRVADLYDYLHPAVLHALKKVVDDAHLEGKPVSICGEMAGDPAAAVLLMAMGFDSLSMNATNLPKVKWLLRQITLDKAR 719
Cdd:PRK11061 633 NTRVASLYDSLHPAMLRALKMIADEAEQHGLPVSLCGEMAGDPMGALLLIGLGYRHLSMNGRSVARVKYLLRHIDLAEAE 712

                        730       740       750
                 ....*....|....*....|....*....|..
gi 15595534  720 DLLGQLLTFDNPQVIHSSLHLALRNLGLGRVI 751
Cdd:PRK11061 713 NLAQRSLEAQLATEVRHQVAAFMERRGLGGLI 744
PtsA COG1080
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate ...
 198-732 0e+00

Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism];


Pssm-ID: 440698 [Multi-domain]  Cd Length: 571  Bit Score: 647.13  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 198 PADLEVVPDK-QVDDIDAEIALFKQALEGVRADMRALSSKLASQLRKEERALFDVYLMMLDDASIGNEVKRIIRTGQW-A 275
Cdd:COG1080  20 EEDLEVPEYTiSPEDVEAEIARLEAALAKAREELEALREKAPEDLGEEEAAIFDAHLLLLEDPELIEEVEELIREGRYnA 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 276 QGALRQVVMEHVQRFELMDDAYLRERASDVKDIGRRLLAYLQEERKQNLT-YPEQTIIVSEELSPAMLGEVPEGRLVGLV 354
Cdd:COG1080 100 EWALKEVIEELAAQFEALDDEYLRERAADIRDVGRRVLRNLLGVEAPDLSdLPEPVILVAHDLTPSDTAQLDPSRVAGFV 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 355 SVLGSGNSHVAILARAMGIPTVMGAVDLPYSKVDGIDLIVDGYHGEVYTNPSAELVRQYSDVVAEERELSKGLAALRELP 434
Cdd:COG1080 180 TDLGGRTSHTAILARSLGIPAVVGLGDALLLVKDGDLVIVDGDAGVVIVNPDEETLAEYRERQAEYAAERAELARLRDLP 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 435 CETLDGHRMPLWVNTGLLADVARAQERGAEGVGLYRTEVPFMINDRFPSEKEQLAIYREQLSAFHPLPVTMRTLDIGGDK 514
Cdd:COG1080 260 AVTLDGVRVELAANIGLPEDAAAALENGAEGVGLFRTEFLFMDRDDLPTEEEQFEAYRAVAEAMGGRPVTIRTLDIGGDK 339

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 515 ALSYFPI-KEDNPFLGWRGIRVTLDHPEIFLVQTRAMLKAS-EGldNLRILLPMISGTHELEEALHLIHRAWGEVRDEGV 592
Cdd:COG1080 340 PLPYLPLpKEENPFLGLRAIRLCLDRPELFRTQLRAILRASaHG--NLRIMFPMISSVEELRQAKALLEEAKAELRAEGI 417

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 593 DIA-MPPIGMMVEIPAAVYQTRELARQVDFLSVGSNDLTQYLLAVDRNNPRVADLYDYLHPAVLHALKKVVDDAHLEGKP 671
Cdd:COG1080 418 PFDeDIPVGIMIEVPAAALIADQLAKEVDFFSIGTNDLIQYTLAVDRGNEKVAYLYDPLHPAVLRLIKMVIDAAHKAGKP 497

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15595534 672 VSICGEMAGDPAAAVLLMAMGFDSLSMNATNLPKVKWLLRQITLDKARDLLGQLLTFDNPQ 732
Cdd:COG1080 498 VGVCGEMAGDPLATPLLLGLGLDELSMSPSSIPAVKAIIRRLDLAEARALAEKALALDTAE 558
PTS_I_fam TIGR01417
phosphoenolpyruvate-protein phosphotransferase; This model recognizes a distinct clade of ...
 210-736 8.76e-140

phosphoenolpyruvate-protein phosphotransferase; This model recognizes a distinct clade of phophoenolpyruvate (PEP)-dependent enzymes. Most members are known or deduced to function as the phosphoenolpyruvate-protein phosphotransferase (or enzyme I) of PTS sugar transport systems. However, some species with both a member of this family and a homolog of the phosphocarrier protein HPr lack a IIC component able to serve as a permease. An HPr homolog designated NPr has been implicated in the regulation of nitrogen assimilation, which demonstrates that not all phosphotransferase system components are associated directly with PTS transport.


Pssm-ID: 273611 [Multi-domain]  Cd Length: 565  Bit Score: 423.43  E-value: 8.76e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   210 DDIDAEIALFKQALEGVRADMRALSSKLASQLRKEERALFDVYLMMLDDASIGNEVKRIIRTGQW-AQGALRQVVMEHVQ 288
Cdd:TIGR01417  33 SQVDQEISRFLSARAKAKEDLETIKTKAGKTFGQEKAAIFEAHILILEDPELTEEVIELIKKDHKnAEFAAHEVFEGQAK 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   289 RFELMDDAYLRERASDVKDIGRRLLAYLQEERKQNLTYPEQ-TIIVSEELSPAMLGEVPEGRLVGLVSVLGSGNSHVAIL 367
Cdd:TIGR01417 113 SLEEMDDEYLKERAADIRDIGNRLLGHLLGVKISDLSEIQDeVILVAEDLTPSETAQLNLKYVKGFLTDAGGKTSHTAIM 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   368 ARAMGIPTVMGAVDLPYSKVDGIDLIVDGYHGEVYTNPSAELVRQYSDVVAEERELSKGLAALRELPCETLDGHRMPLWV 447
Cdd:TIGR01417 193 ARSLEIPAIVGTKSVTSQVKNGDTVIIDGVKGIVIFNPSSETIDKYEAKQEAVSSEKAELAKLKDKPAITLDGHQVELAA 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   448 NTGLLADVARAQERGAEGVGLYRTEVPFMINDRFPSEKEQLAIYREQLSAFHPLPVTMRTLDIGGDKALSYFPI-KEDNP 526
Cdd:TIGR01417 273 NIGTVDDVEGAERNGGEGIGLFRTEFLYMSRDQLPTEEEQFAAYKTVLEAMESDAVIVRTLDIGGDKELPYLNFpKEENP 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   527 FLGWRGIRVTLDHPEIFLVQTRAMLKASEgLDNLRILLPMISGTHELEEALHLIHRAWGEVRDEGVDIAMP-PIGMMVEI 605
Cdd:TIGR01417 353 FLGYRAIRLALEREEILRTQLRAILRASA-YGKLRIMFPMVATVEEIRAVKQELEEEKQELNDEGKAFDENiEVGVMIEI 431

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   606 PAAVYQTRELARQVDFLSVGSNDLTQYLLAVDRNNPRVADLYDYLHPAVLHALKKVVDDAHLEGKPVSICGEMAGDPAAA 685
Cdd:TIGR01417 432 PSAALIADHLAKEVDFFSIGTNDLTQYTLAVDRGNDLISNLYQPYNPAVLRLIKLVIDAAKAEGIWVGMCGEMAGDERAI 511

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15595534   686 VLLMAMGFDSLSMNATNLPKVKWLLRQITLDKARDLLGQLLTFDNPQVIHS 736
Cdd:TIGR01417 512 PLLLGLGLRELSMSASSILRIKMIIRKLNIEECKSLAEKALAQPTTEEVHK 562
PEP-utilizers_C pfam02896
PEP-utilizing enzyme, PEP-binding domain; This entry represents a TIM barrel domain found at ...
 424-713 7.94e-117

PEP-utilizing enzyme, PEP-binding domain; This entry represents a TIM barrel domain found at the C terminus of a number of PEP (phosphoenolpyruvate)-utilizing proteins. In PPDK (Pyruvate phosphate dikinase) this C-terminal domain has been shown to be a PEP-binding domain.


Pssm-ID: 397163 [Multi-domain]  Cd Length: 292  Bit Score: 353.92  E-value: 7.94e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   424 SKGLAALRELPCETLDGHRMPLWVNTGLLADVARAQERGAEGVGLYRTEVPFMINDRFPSEKEQLAIYREQLSAFHPLPV 503
Cdd:pfam02896   1 KAELGKLKDLPAPTADGTKIKVAANIGTPDDAEAALANGAEGIGLYRTEFLFMDRDELPTEDEQFEAYKGVLEAMNGRPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   504 TMRTLDIGGDKALSYFPI-KEDNPFLGWRGIRVTLDHPEIFLVQTRAMLKASEGlDNLRILLPMISGTHELEEALHLIHR 582
Cdd:pfam02896  81 TVRTLDIGGDKELPYLEEpEEMNPFLGWRGIRIGLDRPELFRTQLRAILRASAF-GNLRIMFPMVASVEELREAKAIIEE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   583 AWGEVRDEGVDIAMPPIGMMVEIPAAVYQTRELARQVDFLSVGSNDLTQYLLAVDRNNPRVADLYDYLHPAVLHALKKVV 662
Cdd:pfam02896 160 VKEELDAEVGFDKDIKVGIMIEVPSAALLADQLAKEVDFFSIGTNDLTQYTLAVDRDNERVAYLYDPLHPAVLRLIKEVI 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15595534   663 DDAHLEGKPVSICGEMAGDPAAAVLLMAMGFDSLSMNATNLPKVKWLLRQI 713
Cdd:pfam02896 240 RAAHRHGKWVGICGEMAGDPSAVPLLVGLGLDEFSMSPDSVPRARALLAQI 290
GAF smart00065
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ...
 17-164 9.02e-20

Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.


Pssm-ID: 214500 [Multi-domain]  Cd Length: 149  Bit Score: 86.67  E-value: 9.02e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534     17 DLKAALGIIVQRVKEAMGTQVCSVYLLD-TETQRFVLMATEGLNKRSIGkVSMAPSEGLVGLVGTREEPLNLENAAAHPR 95
Cdd:smart00065   1 DLEELLQTILEELRQLLGADRVLIYLVDeNDRGELVLVAADGLTLPTLG-IRFPLDEGLAGRVAETGRPLNIPDVEADPL 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534     96 YRYFAETGEERYASFLGAPIIHHRRVMGVLVVQQKER-RQFDEGEEAFLVTMSAQLAGVIAHAEATGSIR 164
Cdd:smart00065  80 FAEDLLGRYQGVRSFLAVPLVADGELVGVLALHNKKSpRPFTEEDEELLQALANQLAIALANAQLYEELR 149
 
Name Accession Description Interval E-value
PRK11061 PRK11061
phosphoenolpyruvate--protein phosphotransferase;
1-751 0e+00

phosphoenolpyruvate--protein phosphotransferase;


Pssm-ID: 182937 [Multi-domain]  Cd Length: 748  Bit Score: 824.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534    1 MLNTLRKIVQEVNSAKDLKAALGIIVQRVKEAMGTQVCSVYLLDTETQRFVLMATEGLNKRSIGKVSMAPSEGLVGLVGT 80
Cdd:PRK11061   1 MLTRLREIVEKVASAPRLNEALDILVTETCLAMDTEVCSVYLADHDRRCYYLMATRGLKKPRGRTVTLAFDEGIVGLVGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   81 REEPLNLENAAAHPRYRYFAETGEERYASFLGAPIIHHRRVMGVLVVQQKERRQFDEGEEAFLVTMSAQLAGVIAHAEAT 160
Cdd:PRK11061  81 LAEPINLADAQKHPSFKYIPSVKEERFRAFLGVPIIYRRQLLGVLVVQQRELRQFDESEESFLVTLATQLAAILSQSQLT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  161 GSIRGLgklgkgiQEAKFVGVPGAPGVGVGKAVVVLPPADLEVVPDKQVDDIDAEIALFKQALEGVRADMRALSSKLASQ 240
Cdd:PRK11061 161 ALFGQY-------RQTRIRALPASPGVAIAEGWQDATQPLLEQVYPASTLDPALERERLTGALEEAANEFRRYSKRFAAG 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  241 LRKEERALFDVYLMMLDDASIGNEVKRIIRTGQWAQGALRQVVMEHVQRFELMDDAYLRERASDVKDIGRRLLAYLQEER 320
Cdd:PRK11061 234 AQKETAAIFDLYSHLLNDPRLRRELFAEVDKGSVAEWAVKQVIEKFAEQFAALSDNYLRERAGDLRALGQRLLFHLDDSE 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  321 KQNLTYPEQTIIVSEELSPAMLGEVPEGRLVGLVSVLGSGNSHVAILARAMGIPTVMGAvDLPYSKVDGIDLIVDGYHGE 400
Cdd:PRK11061 314 QGPNAWPERFILVADELTATLLAELPQDRLAGVVVRDGAANSHAAILVRALGIPTVMGA-DIQPSLLHQRLLIVDGYRGE 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  401 VYTNPSAELVRQYSDVVAEERELSKGLAALRELPCETLDGHRMPLWVNTGLLADVARAQERGAEGVGLYRTEVPFMINDR 480
Cdd:PRK11061 393 LLVDPEPVLLQEYQRLISEEIELSRLAEDDVNLPAQLKSGERIKVMLNAGLSAEHEEKLGSRVDGVGLYRTEIPFMLQSG 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  481 FPSEKEQLAIYREQLSAFHPLPVTMRTLDIGGDKALSYFPIKEDNPFLGWRGIRVTLDHPEIFLVQTRAMLKASEGLDNL 560
Cdd:PRK11061 473 FPSEEEQVAQYQGMLQMFPDKPVTLRTLDIGADKQLPYMPISEENPCLGWRGIRITLDQPEIFLIQVRAMLRANAATGNL 552

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  561 RILLPMISGTHELEEALHLIHRAWGEVRDE-GVDIAMPPIGMMVEIPAAVYQTRELARQVDFLSVGSNDLTQYLLAVDRN 639
Cdd:PRK11061 553 SILLPMVTSIDEVDEARRLIDRAGREVEEMlGYEIPKPRIGIMIEVPSMVFMLPHLASRVDFISVGTNDLTQYLLAVDRN 632

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  640 NPRVADLYDYLHPAVLHALKKVVDDAHLEGKPVSICGEMAGDPAAAVLLMAMGFDSLSMNATNLPKVKWLLRQITLDKAR 719
Cdd:PRK11061 633 NTRVASLYDSLHPAMLRALKMIADEAEQHGLPVSLCGEMAGDPMGALLLIGLGYRHLSMNGRSVARVKYLLRHIDLAEAE 712

                        730       740       750
                 ....*....|....*....|....*....|..
gi 15595534  720 DLLGQLLTFDNPQVIHSSLHLALRNLGLGRVI 751
Cdd:PRK11061 713 NLAQRSLEAQLATEVRHQVAAFMERRGLGGLI 744
PtsA COG1080
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate ...
 198-732 0e+00

Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism];


Pssm-ID: 440698 [Multi-domain]  Cd Length: 571  Bit Score: 647.13  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 198 PADLEVVPDK-QVDDIDAEIALFKQALEGVRADMRALSSKLASQLRKEERALFDVYLMMLDDASIGNEVKRIIRTGQW-A 275
Cdd:COG1080  20 EEDLEVPEYTiSPEDVEAEIARLEAALAKAREELEALREKAPEDLGEEEAAIFDAHLLLLEDPELIEEVEELIREGRYnA 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 276 QGALRQVVMEHVQRFELMDDAYLRERASDVKDIGRRLLAYLQEERKQNLT-YPEQTIIVSEELSPAMLGEVPEGRLVGLV 354
Cdd:COG1080 100 EWALKEVIEELAAQFEALDDEYLRERAADIRDVGRRVLRNLLGVEAPDLSdLPEPVILVAHDLTPSDTAQLDPSRVAGFV 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 355 SVLGSGNSHVAILARAMGIPTVMGAVDLPYSKVDGIDLIVDGYHGEVYTNPSAELVRQYSDVVAEERELSKGLAALRELP 434
Cdd:COG1080 180 TDLGGRTSHTAILARSLGIPAVVGLGDALLLVKDGDLVIVDGDAGVVIVNPDEETLAEYRERQAEYAAERAELARLRDLP 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 435 CETLDGHRMPLWVNTGLLADVARAQERGAEGVGLYRTEVPFMINDRFPSEKEQLAIYREQLSAFHPLPVTMRTLDIGGDK 514
Cdd:COG1080 260 AVTLDGVRVELAANIGLPEDAAAALENGAEGVGLFRTEFLFMDRDDLPTEEEQFEAYRAVAEAMGGRPVTIRTLDIGGDK 339

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 515 ALSYFPI-KEDNPFLGWRGIRVTLDHPEIFLVQTRAMLKAS-EGldNLRILLPMISGTHELEEALHLIHRAWGEVRDEGV 592
Cdd:COG1080 340 PLPYLPLpKEENPFLGLRAIRLCLDRPELFRTQLRAILRASaHG--NLRIMFPMISSVEELRQAKALLEEAKAELRAEGI 417

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 593 DIA-MPPIGMMVEIPAAVYQTRELARQVDFLSVGSNDLTQYLLAVDRNNPRVADLYDYLHPAVLHALKKVVDDAHLEGKP 671
Cdd:COG1080 418 PFDeDIPVGIMIEVPAAALIADQLAKEVDFFSIGTNDLIQYTLAVDRGNEKVAYLYDPLHPAVLRLIKMVIDAAHKAGKP 497

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15595534 672 VSICGEMAGDPAAAVLLMAMGFDSLSMNATNLPKVKWLLRQITLDKARDLLGQLLTFDNPQ 732
Cdd:COG1080 498 VGVCGEMAGDPLATPLLLGLGLDELSMSPSSIPAVKAIIRRLDLAEARALAEKALALDTAE 558
PTS_I_fam TIGR01417
phosphoenolpyruvate-protein phosphotransferase; This model recognizes a distinct clade of ...
 210-736 8.76e-140

phosphoenolpyruvate-protein phosphotransferase; This model recognizes a distinct clade of phophoenolpyruvate (PEP)-dependent enzymes. Most members are known or deduced to function as the phosphoenolpyruvate-protein phosphotransferase (or enzyme I) of PTS sugar transport systems. However, some species with both a member of this family and a homolog of the phosphocarrier protein HPr lack a IIC component able to serve as a permease. An HPr homolog designated NPr has been implicated in the regulation of nitrogen assimilation, which demonstrates that not all phosphotransferase system components are associated directly with PTS transport.


Pssm-ID: 273611 [Multi-domain]  Cd Length: 565  Bit Score: 423.43  E-value: 8.76e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   210 DDIDAEIALFKQALEGVRADMRALSSKLASQLRKEERALFDVYLMMLDDASIGNEVKRIIRTGQW-AQGALRQVVMEHVQ 288
Cdd:TIGR01417  33 SQVDQEISRFLSARAKAKEDLETIKTKAGKTFGQEKAAIFEAHILILEDPELTEEVIELIKKDHKnAEFAAHEVFEGQAK 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   289 RFELMDDAYLRERASDVKDIGRRLLAYLQEERKQNLTYPEQ-TIIVSEELSPAMLGEVPEGRLVGLVSVLGSGNSHVAIL 367
Cdd:TIGR01417 113 SLEEMDDEYLKERAADIRDIGNRLLGHLLGVKISDLSEIQDeVILVAEDLTPSETAQLNLKYVKGFLTDAGGKTSHTAIM 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   368 ARAMGIPTVMGAVDLPYSKVDGIDLIVDGYHGEVYTNPSAELVRQYSDVVAEERELSKGLAALRELPCETLDGHRMPLWV 447
Cdd:TIGR01417 193 ARSLEIPAIVGTKSVTSQVKNGDTVIIDGVKGIVIFNPSSETIDKYEAKQEAVSSEKAELAKLKDKPAITLDGHQVELAA 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   448 NTGLLADVARAQERGAEGVGLYRTEVPFMINDRFPSEKEQLAIYREQLSAFHPLPVTMRTLDIGGDKALSYFPI-KEDNP 526
Cdd:TIGR01417 273 NIGTVDDVEGAERNGGEGIGLFRTEFLYMSRDQLPTEEEQFAAYKTVLEAMESDAVIVRTLDIGGDKELPYLNFpKEENP 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   527 FLGWRGIRVTLDHPEIFLVQTRAMLKASEgLDNLRILLPMISGTHELEEALHLIHRAWGEVRDEGVDIAMP-PIGMMVEI 605
Cdd:TIGR01417 353 FLGYRAIRLALEREEILRTQLRAILRASA-YGKLRIMFPMVATVEEIRAVKQELEEEKQELNDEGKAFDENiEVGVMIEI 431

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   606 PAAVYQTRELARQVDFLSVGSNDLTQYLLAVDRNNPRVADLYDYLHPAVLHALKKVVDDAHLEGKPVSICGEMAGDPAAA 685
Cdd:TIGR01417 432 PSAALIADHLAKEVDFFSIGTNDLTQYTLAVDRGNDLISNLYQPYNPAVLRLIKLVIDAAKAEGIWVGMCGEMAGDERAI 511

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15595534   686 VLLMAMGFDSLSMNATNLPKVKWLLRQITLDKARDLLGQLLTFDNPQVIHS 736
Cdd:TIGR01417 512 PLLLGLGLRELSMSASSILRIKMIIRKLNIEECKSLAEKALAQPTTEEVHK 562
PRK11177 PRK11177
phosphoenolpyruvate-protein phosphotransferase PtsI;
210-727 1.81e-135

phosphoenolpyruvate-protein phosphotransferase PtsI;


Pssm-ID: 183017 [Multi-domain]  Cd Length: 575  Bit Score: 412.48  E-value: 1.81e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  210 DDIDAEIALFKQALEGVRADMRALSSKLASQLRKEERALFDVYLMMLDDASIGNEVKRIIRTGQW-AQGALRQVVMEHVQ 288
Cdd:PRK11177  34 DQVDQEVERFLSGRAKASAQLEAIKTKAGETFGEEKEAIFEGHIMLLEDEELEQEIIALIKDKHMtADAAAHSVIEGQAK 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  289 RFELMDDAYLRERASDVKDIGRRLLaylqeerKQNLTYP--------EQTIIVSEELSPAMLGEVPEGRLVGLVSVLGSG 360
Cdd:PRK11177 114 ALEELDDEYLKERAADVRDIGKRLL-------KNILGLKiidlsaiqEEVILVAADLTPSETAQLNLKKVLGFITDIGGR 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  361 NSHVAILARAMGIPTVMGAVDLPYSKVDGIDLIVDGYHGEVYTNPSAELVRQY----SDVVAEERELSKglaaLRELPCE 436
Cdd:PRK11177 187 TSHTSIMARSLELPAIVGTGNITKQVKNGDYLILDAVNNQIYVNPTNEVIEELkavqEQYASEKAELAK----LKDLPAI 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  437 TLDGHRMPLWVNTGLLADVARAQERGAEGVGLYRTEVPFMINDRFPSEKEQLAIYREQLSAFHPLPVTMRTLDIGGDKAL 516
Cdd:PRK11177 263 TLDGHQVEVCANIGTVRDVEGAERNGAEGVGLYRTEFLFMDRDALPTEEEQFQAYKAVAEAMGSQAVIVRTMDIGGDKEL 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  517 SY--FPiKEDNPFLGWRGIRVTLDHPEIFLVQTRAMLKASeGLDNLRILLPMISGTHELEEALHLIHRAWGEVRDEGV-- 592
Cdd:PRK11177 343 PYmnLP-KEENPFLGWRAIRIAMDRKEILHDQLRAILRAS-AFGKLRIMFPMIISVEEVRELKAEIEILKQELRDEGKaf 420

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  593 --DIAmppIGMMVEIPAAVYQTRELARQVDFLSVGSNDLTQYLLAVDRNNPRVADLYDYLHPAVLHALKKVVDDAHLEGK 670
Cdd:PRK11177 421 deSIE---IGVMVETPAAAVIARHLAKEVDFFSIGTNDLTQYTLAVDRGNELISHLYNPMSPSVLNLIKQVIDASHAEGK 497

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 15595534  671 PVSICGEMAGDPAAAVLLMAMGFDSLSMNATNLPKVKWLLRQITLDKARDLLGQLLT 727
Cdd:PRK11177 498 WTGMCGELAGDERATLLLLGMGLDEFSMSAISIPRIKKIIRNTNFEDAKALAEQALA 554
PEP-utilizers_C pfam02896
PEP-utilizing enzyme, PEP-binding domain; This entry represents a TIM barrel domain found at ...
 424-713 7.94e-117

PEP-utilizing enzyme, PEP-binding domain; This entry represents a TIM barrel domain found at the C terminus of a number of PEP (phosphoenolpyruvate)-utilizing proteins. In PPDK (Pyruvate phosphate dikinase) this C-terminal domain has been shown to be a PEP-binding domain.


Pssm-ID: 397163 [Multi-domain]  Cd Length: 292  Bit Score: 353.92  E-value: 7.94e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   424 SKGLAALRELPCETLDGHRMPLWVNTGLLADVARAQERGAEGVGLYRTEVPFMINDRFPSEKEQLAIYREQLSAFHPLPV 503
Cdd:pfam02896   1 KAELGKLKDLPAPTADGTKIKVAANIGTPDDAEAALANGAEGIGLYRTEFLFMDRDELPTEDEQFEAYKGVLEAMNGRPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   504 TMRTLDIGGDKALSYFPI-KEDNPFLGWRGIRVTLDHPEIFLVQTRAMLKASEGlDNLRILLPMISGTHELEEALHLIHR 582
Cdd:pfam02896  81 TVRTLDIGGDKELPYLEEpEEMNPFLGWRGIRIGLDRPELFRTQLRAILRASAF-GNLRIMFPMVASVEELREAKAIIEE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   583 AWGEVRDEGVDIAMPPIGMMVEIPAAVYQTRELARQVDFLSVGSNDLTQYLLAVDRNNPRVADLYDYLHPAVLHALKKVV 662
Cdd:pfam02896 160 VKEELDAEVGFDKDIKVGIMIEVPSAALLADQLAKEVDFFSIGTNDLTQYTLAVDRDNERVAYLYDPLHPAVLRLIKEVI 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15595534   663 DDAHLEGKPVSICGEMAGDPAAAVLLMAMGFDSLSMNATNLPKVKWLLRQI 713
Cdd:pfam02896 240 RAAHRHGKWVGICGEMAGDPSAVPLLVGLGLDEFSMSPDSVPRARALLAQI 290
PtsP COG3605
Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];
1-164 1.97e-74

Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];


Pssm-ID: 442824 [Multi-domain]  Cd Length: 188  Bit Score: 239.41  E-value: 1.97e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   1 MLNTLRKIVQEVNSAKDLKAALGIIVQRVKEAMGTQVCSVYLLDTETQRFVLMATEGLNKRSIGKVSMAPSEGLVGLVGT 80
Cdd:COG3605   2 MLKALRRISEAVASALDLDEALDRIVRRIAEALGVDVCSIYLLDPDGGRLELRATEGLNPEAVGKVRLPLGEGLVGLVAE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  81 REEPLNLENAAAHPRYRYFAETGEERYASFLGAPIIHHRRVMGVLVVQQKERRQFDEGEEAFLVTMSAQLAGVIAHAEAT 160
Cdd:COG3605  82 RGEPLNLADAASHPRFKYFPETGEEGFRSFLGVPIIRRGRVLGVLVVQSREPREFTEEEVEFLVTLAAQLAEAIANAELL 161


                ....
gi 15595534 161 GSIR 164
Cdd:COG3605 162 GELR 165
PRK06464 PRK06464
phosphoenolpyruvate synthase; Validated
 362-699 2.75e-53

phosphoenolpyruvate synthase; Validated


Pssm-ID: 235809 [Multi-domain]  Cd Length: 795  Bit Score: 197.66  E-value: 2.75e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  362 SHVAILARAMGIPTVMGAVDlpyskvdGIDLIVDGyhgEVYTNPSAE----LVrqYSDVVAEERElSKGLAALRELPCET 437
Cdd:PRK06464 417 CHAAIIARELGIPAVVGTGN-------ATEVLKDG---QEVTVSCAEgdtgYV--YEGLLEFEVE-EVSLEEMPETPTKI 483

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  438 LdghrmplwVNTGLlADVA-RAQERGAEGVGLYRTEvpFMIN-----------------DRFPSEKEQLAI--------Y 491
Cdd:PRK06464 484 M--------MNVGN-PERAfDFAALPNDGVGLARLE--FIINnmigvhplallefdqqdADLKAEIEELTAgyaspeefY 552

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  492 REQL--------SAFHPLPVTMRTLD---------IGGDKalsYFPiKEDNPFLGWRGIRVTLDHP--EIFLVQTRAMLK 552
Cdd:PRK06464 553 VDKLaegiatvaAAFYPKPVIVRLSDfksneyanlIGGER---YEP-EEENPMLGFRGASRYLSESfrEAFALECEAIKR 628

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  553 ASE--GLDNLRILLPMISGTHELEEALHLIhRAWGEVRDE-GVDIamppiGMMVEIPAAVYQTRELARQVDFLSVGSNDL 629
Cdd:PRK06464 629 VREemGLTNVEVMIPFVRTVEEAEKVIELL-AENGLKRGEnGLKV-----IMMCEIPSNALLAEEFLEYFDGFSIGSNDL 702

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15595534  630 TQYLLAVDRNNPRVADLYDYLHPAVLHALKKVVDDAHLEGKPVSICGEMAGD-PAAAVLLMAMGFDSLSMN 699
Cdd:PRK06464 703 TQLTLGLDRDSGLVAHLFDERNPAVKKLISMAIKAAKKAGKYVGICGQAPSDhPDFAEWLVEEGIDSISLN 773
PEP-utilizers_N pfam05524
PEP-utilizing enzyme, N-terminal;
197-301 8.74e-27

PEP-utilizing enzyme, N-terminal;


Pssm-ID: 461671 [Multi-domain]  Cd Length: 125  Bit Score: 105.77  E-value: 8.74e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   197 PPADLEVVPDKQVDDIDAEIALFKQALEGVRADMRALSSKLASQLRKEERALFDVYLMMLDDASIGNEVKRIIRTGQ-WA 275
Cdd:pfam05524  20 PELEVPDEREVPADDVEAEIARLEAALEAAREELEALAERAAGELGEEEAAIFEAHLMMLEDPELLEEVEELIREGGlNA 99

                          90       100
                  ....*....|....*....|....*.
gi 15595534   276 QGALRQVVMEHVQRFELMDDAYLRER 301
Cdd:pfam05524 100 EAAVKEVVDEFAAMFEAMDDPYLRER 125
PRK11377 PRK11377
dihydroxyacetone kinase subunit M; Provisional
 197-401 2.57e-26

dihydroxyacetone kinase subunit M; Provisional


Pssm-ID: 183108 [Multi-domain]  Cd Length: 473  Bit Score: 113.31  E-value: 2.57e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  197 PPADLEVVPdKQVDDIDAEIALFKQALEGVRADMRALSSKLASQLRKEERALFDVYLMMLDDASIGNEVKRIIRTGQW-A 275
Cdd:PRK11377 265 QPVLCTVQA-KSTLTVEEEQERLRQAIDFTLLDLMTLTAKAEASGLDDIAAIFSGHHTLLDDPELLAAASERLQHEHCtA 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  276 QGALRQVVMEHVQRFELMDDAYLRERASDVKDIGRRLLAYLQEERKQNLTYPEQTIIVSEELSPAMLGEVPEGRLVGLVS 355
Cdd:PRK11377 344 EYAWQQVLKELSQQYQQLDDEYLQARYIDVDDLLHRTLVHLTQTKEELPQFNSPTILLAENIYPSTVLQLDPAVVKGICL 423

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 15595534  356 VLGSGNSHVAILARAMGIPTVMGAVDLPYSKVDGIDLIVDGYHGEV 401
Cdd:PRK11377 424 SAGSPLSHSAIIARELGIGWICQQGEKLYAIQPEETLTLDVKTQRL 469
GAF smart00065
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ...
 17-164 9.02e-20

Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.


Pssm-ID: 214500 [Multi-domain]  Cd Length: 149  Bit Score: 86.67  E-value: 9.02e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534     17 DLKAALGIIVQRVKEAMGTQVCSVYLLD-TETQRFVLMATEGLNKRSIGkVSMAPSEGLVGLVGTREEPLNLENAAAHPR 95
Cdd:smart00065   1 DLEELLQTILEELRQLLGADRVLIYLVDeNDRGELVLVAADGLTLPTLG-IRFPLDEGLAGRVAETGRPLNIPDVEADPL 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534     96 YRYFAETGEERYASFLGAPIIHHRRVMGVLVVQQKER-RQFDEGEEAFLVTMSAQLAGVIAHAEATGSIR 164
Cdd:smart00065  80 FAEDLLGRYQGVRSFLAVPLVADGELVGVLALHNKKSpRPFTEEDEELLQALANQLAIALANAQLYEELR 149
PEP-utilizers pfam00391
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain ...
 327-399 4.51e-18

PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.


Pssm-ID: 459796 [Multi-domain]  Cd Length: 73  Bit Score: 78.99  E-value: 4.51e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15595534   327 PEQTIIVSEELSPAMLGEVPegRLVGLVSVLGSGNSHVAILARAMGIPTVMGAVDLPYSKVDGIDLIVDGYHG 399
Cdd:pfam00391   3 PEGVILVAPDTTPSDTAGLD--KAAGIVTERGGMTSHAAIVARELGIPAVVGVGDATILLKEGDLVTVDGSTG 73
GAF pfam01590
GAF domain; This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl ...
 17-154 2.21e-16

GAF domain; This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54. This domain can bind biliverdine and phycocyanobilin (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460259 [Multi-domain]  Cd Length: 133  Bit Score: 76.36  E-value: 2.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534    17 DLKAALGIIVQRVKEAMGTQVCSVYLLDTETQRFVlmaTEGLNKRSIGKVSMAPSEGlvGLVGTREEPLNLENAAAHPRY 96
Cdd:pfam01590   1 DLEEILQTILEELRELLGADRCALYLPDADGLEYL---PPGARWLKAAGLEIPPGTG--VTVLRTGRPLVVPDAAGDPRF 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15595534    97 -RYFAETGEERYASFLGAPIIHHRRVMGVLVVQQKeRRQFDEGEEAFLVTMSAQLAGVI 154
Cdd:pfam01590  76 lDPLLLLRNFGIRSLLAVPIIDDGELLGVLVLHHP-RPPFTEEELELLEVLADQVAIAL 133
GAF COG2203
GAF domain [Signal transduction mechanisms];
2-495 2.29e-15

GAF domain [Signal transduction mechanisms];


Pssm-ID: 441805 [Multi-domain]  Cd Length: 712  Bit Score: 80.24  E-value: 2.29e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534   2 LNTLRKIVQEVNSAKDLKAALGIIVQRVKEAMGTQVCSVYLLDTETQRFVLMATEGLNKRSIGKVSMapSEGLVGLVGTR 81
Cdd:COG2203 192 LALLNEISQALRSALDLEELLQRILELAGELLGADRGAILLVDEDGGELELVAAPGLPEEELGRLPL--GEGLAGRALRT 269

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534  82 EEPLNLENAAAHPRYR--YFAETGEERYASFLGAPIIHHRRVMGVLVVQQKERRQFDEGEEAFLVTMSAQLAGVIAHAEA 159
Cdd:COG2203 270 GEPVVVNDASTDPRFApsLRELLLALGIRSLLCVPLLVDGRLIGVLALYSKEPRAFTEEDLELLEALADQAAIAIERARL 349

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 160 -TGSIRGLGKLGKGIQEAKFVGVPGAPGVGVGKAVVVLPPADLEVVPDKQVDDIDAEIALFKQALEGVRADMRALSSKLA 238
Cdd:COG2203 350 yEALEAALAALLQELALLRLLLDLELTLLRLRQLLLELLLALLLLLSLLGAELLLLLLDAADLSGLLALEGLLLLDLLLL 429

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 239 SQLRKEERALFDVYLMMLDDASIGNEVKRIIRTGQWAQGALRQVVMEHVQRFELMDDAYLRERASDVKDIGRRLLAYLQE 318
Cdd:COG2203 430 LLLLRRILLLRVLRRLLLGDEEGLVLLLALAELELLEILELLVLLAVILLALALLAALLLLLLLLLALLALSALAVLASL 509

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 319 ERKQNLTYPEQTIIVSEELSPAMLGEVPEGRLVGLVSVLGSGNSHVAILARAMGIPTVMGAVDLPYSKVDGIDLIVDGYH 398
Cdd:COG2203 510 LLALLLLLLLLLLLLLLGLLAALAADLLLLAAALLEDLLILLLVLLLERELLTLVGVLLLLGLSVLLIELALALILALAL 589

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534 399 GEVYTNPSAELVRQYSDVVAEERELSKGLAALRELPCETLDGHRMPLWVNTGLLADVARAQERGAEGVGLYRTEVPFMIN 478
Cdd:COG2203 590 LELLLVAVGDLLLLERDLLLLLVLLVRLLLELLVVTLELTVLVVLAAVEDSALLLRLALALASLVLLRALLATELDLILD 669

                       490
                ....*....|....*..
gi 15595534 479 DRFPSEKEQLAIYREQL 495
Cdd:COG2203 670 SSLLLGLLLLGALLLLG 686
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 15-155 1.85e-12

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 65.18  E-value: 1.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534    15 AKDLKAALGIIVQRVKEAMGTQVCSVYLLDTETQrfvLMATEGLNKRSIGKVSMAPSEGLVGLVGTREEPLNLENAAAHP 94
Cdd:pfam13185   1 AADLEELLDAVLEAAVELGASAVGFILLVDDDGR---LAAWGGAADELSAALDDPPGEGLVGEALRTGRPVIVNDLAADP 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15595534    95 RYRYFAEtGEERYASFLGAPIIHHRRVMGVLVVQQKERRQFDEGEEAFLVTMSAQLAGVIA 155
Cdd:pfam13185  78 AKKGLPA-GHAGLRSFLSVPLVSGGRVVGVLALGSNRPGAFDEEDLELLELLAEQAAIAIE 137
GAF_3 pfam13492
GAF domain;
17-156 1.12e-11

GAF domain;


Pssm-ID: 433253 [Multi-domain]  Cd Length: 129  Bit Score: 62.77  E-value: 1.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534    17 DLKAALGIIVQRVKEAMGTQVCSVYLLDTETQRFVLMATEGLNKRSigKVSMAPSEGLVGLVGTREEPLNlenaaahprY 96
Cdd:pfam13492   1 SLDEILEALLKLLVRLLGAERAAVYLLDEDGNKLQVAAGYDGEPDP--SESLDADSPLARRALSSGEPIS---------G 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595534    97 RYFAETGEERYASFLGAPIIHHRRVMGVLVVQQKERRQFDEGEEAFLVTMSAQLAGVIAH 156
Cdd:pfam13492  70 LGSAGEDGLPDGPALVVPLVAGRRVIGVLALASSKPRAFDAEDLRLLESLAAQIATAIEN 129
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
325-402 9.66e-05

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 45.28  E-value: 9.66e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15595534 325 TYPEQTIIVSEELSPAMLGEVPegRLVGLVSVLGSGNSHVAILARAMGIPTVMGAvDLPYSKV-DGIDLIVDGYHGEVY 402
Cdd:COG3848 239 KFEEGDILVVPSTDAEFVPAIE--KAAGIITEEGGLTSHAAIVGLELGIPVIVGA-EGATEILkDGQVVTVDAERGVVY 314
FhlA COG3604
FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis ...
 100-154 2.70e-04

FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 442823 [Multi-domain]  Cd Length: 338  Bit Score: 43.68  E-value: 2.70e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15595534 100 AETGEERYASFLGAPIIHHRRVMGVLVVQQKERRQFDEGEEAFLVTMSAQLAGVI 154
Cdd:COG3604  66 AALAARERQLFLGVPLRVGGEVLGVLTLDSRRPGAFSEEDLRLLETLASLAAVAI 120
PpsA COG0574
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and ...
 331-401 5.04e-04

Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase is part of the Pathway/BioSystem: Gluconeogenesis


Pssm-ID: 440339 [Multi-domain]  Cd Length: 455  Bit Score: 43.28  E-value: 5.04e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15595534 331 IIVSEELSPAMLGEVPegRLVGLVSVLGSGNSHVAILARAMGIPTVMGAVD----LPyskvDGIDLIVDGYHGEV 401
Cdd:COG0574 386 ILVRDETDPDDVPGMK--AAAGIVTERGGMTSHAAIVARELGIPAVVGCGDatrvLK----DGDEITVDGTTGEV 454
PRK05878 PRK05878
pyruvate phosphate dikinase; Provisional
 328-402 4.77e-03

pyruvate phosphate dikinase; Provisional


Pssm-ID: 235635 [Multi-domain]  Cd Length: 530  Bit Score: 40.11  E-value: 4.77e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15595534  328 EQTIIVSEELSP----AMLGEVpegrlvGLVSVLGSGNSHVAILARAMGIPTVMGAVDLPYSKVDGIDLIVDGYHGEVY 402
Cdd:PRK05878 380 EPVILVRDHTRPddvhGMLAAQ------GIVTEVGGATSHAAVVSRELGRVAVVGCGAGVAAALAGKEITVDGYEGEVR 452
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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