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Conserved domains on  [gi|15595540|ref|NP_249034|]
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hypothetical protein PA0343 [Pseudomonas aeruginosa PAO1]

Protein Classification

FkbM family methyltransferase( domain architecture ID 10019074)

FkbM family methyltransferase is a class I SAM-dependent methyltransferase, similar to Sinorhizobium fredii 2-O-methyltransferase NoeI, which is required for 2-O-methylation of the fucosyl group of Nod factors

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 26-164 2.20e-32

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


:

Pssm-ID: 273628  Cd Length: 143  Bit Score: 115.87  E-value: 2.20e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595540    26 FYIDVGANHPRIdSVTLAFYERGWRGINIEPLPHLHRELERE-RPEDLN----LNLAIGEREGRAtlyEMAASGLSTLDP 100
Cdd:TIGR01444   1 VVIDVGANIGDT-SLYFARKGAEGRVIAFEPLPDAYEILEENvKLNNLPnvvlLNAAVGDRDGEL---EFNVSDDDTGNS 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15595540   101 ELARQRQAEgcTATPREVKVSTLDAICAAHVEGPIHFLKIDVEGLEGAVLRGLD--LNRWRPWLIL 164
Cdd:TIGR01444  77 SLLPTPDAD--RESEIEVEVVTLDDLVEEFGLDKVDLLKIDVEGAELEVLRGAAetLLEKRPVIVL 140
 
Name Accession Description Interval E-value
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 26-164 2.20e-32

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 115.87  E-value: 2.20e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595540    26 FYIDVGANHPRIdSVTLAFYERGWRGINIEPLPHLHRELERE-RPEDLN----LNLAIGEREGRAtlyEMAASGLSTLDP 100
Cdd:TIGR01444   1 VVIDVGANIGDT-SLYFARKGAEGRVIAFEPLPDAYEILEENvKLNNLPnvvlLNAAVGDRDGEL---EFNVSDDDTGNS 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15595540   101 ELARQRQAEgcTATPREVKVSTLDAICAAHVEGPIHFLKIDVEGLEGAVLRGLD--LNRWRPWLIL 164
Cdd:TIGR01444  77 SLLPTPDAD--RESEIEVEVVTLDDLVEEFGLDKVDLLKIDVEGAELEVLRGAAetLLEKRPVIVL 140
Methyltransf_21 pfam05050
Methyltransferase FkbM domain; This family has members from bacteria to human, and appears to ...
 29-186 7.99e-29

Methyltransferase FkbM domain; This family has members from bacteria to human, and appears to be a methyltransferase.


Pssm-ID: 428282  Cd Length: 170  Bit Score: 107.65  E-value: 7.99e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595540    29 DVGANHPRIDSVTLAFY-ERGWRGIN--IEPLPHLHrelerERPEDLNLNLAIGEREGRATLYEMAASGLSTL------D 99
Cdd:pfam05050   1 DVGANDGVWDSVALLFEkKCGGGGEVlaIEPNPNKL-----EKLDCTLLNLALGNDVGLYEFYLGGKGGGGYLlfavgdP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595540   100 PELARQRQAEGCTATPREVKVSTLDAICAAHVEGPIHFLKIDVEGLEGAVLRGL--DLNRWRPWLILAETPFDHDPEWKA 177
Cdd:pfam05050  76 QGASTSSVLGGEEAKYIEVETVTLDSFLEEIKKSDIDLLKIDVEGAELEVLEGAekTLKRCQPNIIVIEVHFFHYFGGPL 155

                         170
                  ....*....|....*
gi 15595540   178 P------LLAAGYRF 186
Cdd:pfam05050 156 FdeirqfLRECGYRL 170
 
Name Accession Description Interval E-value
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 26-164 2.20e-32

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 115.87  E-value: 2.20e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595540    26 FYIDVGANHPRIdSVTLAFYERGWRGINIEPLPHLHRELERE-RPEDLN----LNLAIGEREGRAtlyEMAASGLSTLDP 100
Cdd:TIGR01444   1 VVIDVGANIGDT-SLYFARKGAEGRVIAFEPLPDAYEILEENvKLNNLPnvvlLNAAVGDRDGEL---EFNVSDDDTGNS 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15595540   101 ELARQRQAEgcTATPREVKVSTLDAICAAHVEGPIHFLKIDVEGLEGAVLRGLD--LNRWRPWLIL 164
Cdd:TIGR01444  77 SLLPTPDAD--RESEIEVEVVTLDDLVEEFGLDKVDLLKIDVEGAELEVLRGAAetLLEKRPVIVL 140
Methyltransf_21 pfam05050
Methyltransferase FkbM domain; This family has members from bacteria to human, and appears to ...
 29-186 7.99e-29

Methyltransferase FkbM domain; This family has members from bacteria to human, and appears to be a methyltransferase.


Pssm-ID: 428282  Cd Length: 170  Bit Score: 107.65  E-value: 7.99e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595540    29 DVGANHPRIDSVTLAFY-ERGWRGIN--IEPLPHLHrelerERPEDLNLNLAIGEREGRATLYEMAASGLSTL------D 99
Cdd:pfam05050   1 DVGANDGVWDSVALLFEkKCGGGGEVlaIEPNPNKL-----EKLDCTLLNLALGNDVGLYEFYLGGKGGGGYLlfavgdP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595540   100 PELARQRQAEGCTATPREVKVSTLDAICAAHVEGPIHFLKIDVEGLEGAVLRGL--DLNRWRPWLILAETPFDHDPEWKA 177
Cdd:pfam05050  76 QGASTSSVLGGEEAKYIEVETVTLDSFLEEIKKSDIDLLKIDVEGAELEVLEGAekTLKRCQPNIIVIEVHFFHYFGGPL 155

                         170
                  ....*....|....*
gi 15595540   178 P------LLAAGYRF 186
Cdd:pfam05050 156 FdeirqfLRECGYRL 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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