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Conserved domains on  [gi|15595550|ref|NP_249044|]
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dihydroxy-acid dehydratase [Pseudomonas aeruginosa PAO1]

Protein Classification

dihydroxy-acid dehydratase( domain architecture ID 10013972)

dihydroxy-acid dehydratase catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis

EC:  4.2.1.9
Gene Symbol:  ilvD
PubMed:  35263023|12242394

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK12448 PRK12448
dihydroxy-acid dehydratase; Provisional
2-612 0e+00

dihydroxy-acid dehydratase; Provisional


:

Pssm-ID: 237104  Cd Length: 615  Bit Score: 1393.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550    2 PDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDD 81
Cdd:PRK12448   1 PKYRSRTTTHGRNMAGARALWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   82 GIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLAS--HG 159
Cdd:PRK12448  81 GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDkiIK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  160 LDLVDAMVVAADDSCSDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGRLAVE 239
Cdd:PRK12448 161 LDLVDAMVAAADPSVSDEDVAQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATHADRKQLFLEAGRRIVE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  240 LCQRYYGEGDDSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPNIQKY 319
Cdd:PRK12448 241 LAKRYYEQDDESVLPRSIATKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEVDFTMADIDRLSRKVPCLCKVAPNTQKY 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  320 HMEDVHRAGGIFSILGELARGGLLHTDVPTVHSPSMADAIAQWDITQTRDEAVHTFFKAGPAGIPTQTAFSQNTRWPSLD 399
Cdd:PRK12448 321 HMEDVHRAGGIMGILGELDRAGLLHTDVPTVHGLTLGEALDQWDIMRTQDEAVKEFFRAAPGGIRTTVAFSQDCRWDSLD 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  400 DDRAEGCIRSVEHAYSKEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDAAVKGILGDEVKAGDIVIIRYE 479
Cdd:PRK12448 401 TDRENGCIRSVEHAYSKDGGLAVLYGNIAEDGCIVKTAGVDESILKFTGPARVFESQDDAVEAILGGKVKAGDVVVIRYE 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  480 GPKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLVS 559
Cdd:PRK12448 481 GPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGAIGLVEDGDIIEIDIPNRSINLLVS 560
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15595550  560 DEELAARRAEQDKKG---WKPaAPRARRVSTALKAYALLATSADKGAVRNKALLDG 612
Cdd:PRK12448 561 DEELAARRAAQEARGdkaWKP-KNRERKVSFALKAYAALATSADKGAVRDKSKLGG 615
 
Name Accession Description Interval E-value
PRK12448 PRK12448
dihydroxy-acid dehydratase; Provisional
2-612 0e+00

dihydroxy-acid dehydratase; Provisional


Pssm-ID: 237104  Cd Length: 615  Bit Score: 1393.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550    2 PDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDD 81
Cdd:PRK12448   1 PKYRSRTTTHGRNMAGARALWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   82 GIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLAS--HG 159
Cdd:PRK12448  81 GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDkiIK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  160 LDLVDAMVVAADDSCSDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGRLAVE 239
Cdd:PRK12448 161 LDLVDAMVAAADPSVSDEDVAQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATHADRKQLFLEAGRRIVE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  240 LCQRYYGEGDDSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPNIQKY 319
Cdd:PRK12448 241 LAKRYYEQDDESVLPRSIATKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEVDFTMADIDRLSRKVPCLCKVAPNTQKY 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  320 HMEDVHRAGGIFSILGELARGGLLHTDVPTVHSPSMADAIAQWDITQTRDEAVHTFFKAGPAGIPTQTAFSQNTRWPSLD 399
Cdd:PRK12448 321 HMEDVHRAGGIMGILGELDRAGLLHTDVPTVHGLTLGEALDQWDIMRTQDEAVKEFFRAAPGGIRTTVAFSQDCRWDSLD 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  400 DDRAEGCIRSVEHAYSKEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDAAVKGILGDEVKAGDIVIIRYE 479
Cdd:PRK12448 401 TDRENGCIRSVEHAYSKDGGLAVLYGNIAEDGCIVKTAGVDESILKFTGPARVFESQDDAVEAILGGKVKAGDVVVIRYE 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  480 GPKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLVS 559
Cdd:PRK12448 481 GPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGAIGLVEDGDIIEIDIPNRSINLLVS 560
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15595550  560 DEELAARRAEQDKKG---WKPaAPRARRVSTALKAYALLATSADKGAVRNKALLDG 612
Cdd:PRK12448 561 DEELAARRAAQEARGdkaWKP-KNRERKVSFALKAYAALATSADKGAVRDKSKLGG 615
IlvD COG0129
Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, ...
1-607 0e+00

Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; Dihydroxyacid dehydratase/phosphogluconate dehydratase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439899  Cd Length: 558  Bit Score: 1029.57  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   1 MPDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVD 80
Cdd:COG0129   1 MPKMRSDTVTKGRERAPARALLRATGLTDEDFGKPIIGIANSWNEIVPGHVHLDDLAEAVKEGIRAAGGVPFEFNTIAVS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  81 DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKlashG- 159
Cdd:COG0129  81 DGIAMGHEGMRYSLPSRELIADSIETMVNAHCFDGLVCIPGCDKITPGMLMAAARLNIPSIFVYGGPMLPGKYD----Gk 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550 160 ----LDLVDAMVVAADDSCSDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGR 235
Cdd:COG0129 157 dldiVDVFEAVGAYAAGKISDEELKEIERNACPGCGSCSGMFTANTMACLTEALGLSLPGSGTIPAVSAERRRLAREAGR 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550 236 LAVELCQRyygegddSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPN 315
Cdd:COG0129 237 RIVELVEK-------DIKPRDILTREAFENAIAVDMALGGSTNTVLHLLAIAHEAGVDLTLDDFDRISRRTPHLCDLKPS 309
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550 316 IqKYHMEDVHRAGGIFSILGELARGGLLHTDVPTVHSPSMADAIAQWDItqtrdeavhtffkagpagiptqtafsqntrw 395
Cdd:COG0129 310 G-KYHMEDLHRAGGIPAVMKELLDAGLLHGDCLTVTGKTLAENLADADI------------------------------- 357
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550 396 pslddDRAEGCIRSVEHAYSKEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDAAVKGILGDEVKAGDIVI 475
Cdd:COG0129 358 -----DRDQDVIRPLDNPYSPTGGLAILRGNLAPDGAVVKTAGVDESMLVFEGPARVFDSEEEAVEAILGGKIKAGDVVV 432
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550 476 IRYEGPKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSIN 555
Cdd:COG0129 433 IRYEGPKGGPGMREMLSPTSALKGMGLGKSVALITDGRFSGGTRGLSIGHVSPEAAEGGPIALVEDGDIITIDIPARTLD 512
                       570       580       590       600       610
                ....*....|....*....|....*....|....*....|....*....|..
gi 15595550 556 LLVSDEELAARRAEqdkkgWKPaaPRARRVSTALKAYALLATSADKGAVRNK 607
Cdd:COG0129 513 LLVSDEELARRRAA-----WKP--PEPRVTSGVLAKYAKLVSSASKGAVTDP 557
ILVD_EDD pfam00920
Dehydratase family;
34-603 0e+00

Dehydratase family;


Pssm-ID: 459998  Cd Length: 513  Bit Score: 863.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550    34 KPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCA 113
Cdd:pfam00920   1 KPIIGIANSYSDLVPCHVHLRELAEAVKEGVREAGGVPAEFNTIGVCDGIAMGHEGMRYSLPSRELIADSIEEMLRAHPF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   114 DAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKtklasHGLDLVDAMVVAADDSCSDEKVAEYERSACPTCGSC 193
Cdd:pfam00920  81 DGLVLIGGCDKIVPGMLMAAARLNIPAIFVSGGPMLPGG-----SGTDEFEAVGAYAAGKISEEELLEIERAACPGCGSC 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   194 SGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGRLAVELCQRyygegddSVLPRNIANFKAFENAMTLDIAM 273
Cdd:pfam00920 156 GGMGTANTMACLAEALGLSLPGSATIPAVSAERLRLAREAGRRIVELVEE-------DIKPRDILTRKAFENAIVVDMAL 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   274 GGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPNiQKYHMEDVHRAGGIFSILGELARgGLLHTDVPTVHSP 353
Cdd:pfam00920 229 GGSTNAVLHLLAIAREAGVDLTLDDFDRISRKVPLLADLKPS-GKYLMEDFHRAGGVPAVLKELLD-ALLHGDVLTVTGK 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   354 SMADAIAQwditqtrdeavhtffkagpagiptqtafsqntrwpslDDDRAEGCIRSVEHAYSKEGGLAVLYGNIALDGCV 433
Cdd:pfam00920 307 TLGENLAD-------------------------------------AEVRDQDVIRPLDNPISPTGGLAVLKGNLAPDGAV 349
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   434 VKTAGVDESIHVFEGSAKIFESQDAAVKGILGDEVKAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGR 513
Cdd:pfam00920 350 VKTSAVDPEMLVFEGPARVFDSEEDALAAILDGKIKAGDVVVIRYEGPKGGPGMPEMLTPTSALLGAGLGKDVALITDGR 429
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   514 FSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLVSDEELAARRAEqdkkgWKPAAPRARRvSTALKAYA 593
Cdd:pfam00920 430 FSGASRGPSIGHVSPEAAVGGPIALVRDGDIIRIDIPNRTLDLLVSDEELAARRAA-----WKPPEPKVKG-RGYLAKYA 503
                         570
                  ....*....|
gi 15595550   594 LLATSADKGA 603
Cdd:pfam00920 504 KLVSSASEGA 513
ilvD TIGR00110
dihydroxy-acid dehydratase; This protein, dihydroxy-acid dehydratase, catalyzes the fourth ...
24-605 0e+00

dihydroxy-acid dehydratase; This protein, dihydroxy-acid dehydratase, catalyzes the fourth step in valine and isoleucine biosynthesis. It contains a catalytically essential [4Fe-4S] cluster This model generates scores of up to 150 bits vs. 6-phosphogluconate dehydratase, a homologous enzyme. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272910  Cd Length: 535  Bit Score: 824.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550    24 ATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADS 103
Cdd:TIGR00110   1 ATGFTDEDFGKPFIGVANSYTTIVPGHMHLRDLAQAVKEGIEAAGGVAFEFNTIAVCDGIAMGHEGMKYSLPSREIIADS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   104 VEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLASH--GLDLVDAMVVAADDSCSDEKVAE 181
Cdd:TIGR00110  81 VETMVNAHRFDGLVCIPSCDKITPGMLMAAARLNIPSIFVTGGPMLPGHTKLGKKidLVSAFEAVGEYAAGKISEEELEE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   182 YERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGRLAVELCQRYYgegddsvLPRNIANFK 261
Cdd:TIGR00110 161 IERSACPGCGSCSGMFTANTMACLTEALGLSLPGCSTMLATSAEKKRIAKNSGKRIVELVKKNI-------KPRDILTKE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   262 AFENAMTLDIAMGGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPNIQKYhMEDVHRAGGIFSILGELARGG 341
Cdd:TIGR00110 234 AFENAITVDMALGGSTNTVLHLLAIANEAGVDLSLDDFDRLSRKVPHIASLAPSGKYV-MEDLHRAGGIPAVLKELDREG 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   342 LLHTDVPTVHSPSMADAIAQWDITQTRDEavhtffkagpagiptqtafsqntrwpsldddraegCIRSVEHAYSKEGGLA 421
Cdd:TIGR00110 313 LLHGDTLTVTGKTLGEILEQAPVIPEGQD-----------------------------------VIRPLDNPVHQEGGLA 357
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   422 VLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDAAVKGILGDEVKAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKG 501
Cdd:TIGR00110 358 ILKGNLAPNGAVVKIAGVDEDMTKFEGPAKVFESEEEALEAILGGKIKEGDVVVIRYEGPKGGPGMPEMLAPTSAIKGMG 437
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   502 LGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLVSDEELAARRAEQDKKGWkpaapr 581
Cdd:TIGR00110 438 LGKSVALITDGRFSGGTRGLCIGHVSPEAAEGGPIALVEDGDIIIIDIPNRKLDLQVSDEELAERRASWKAPEP------ 511
                         570       580
                  ....*....|....*....|....
gi 15595550   582 aRRVSTALKAYALLATSADKGAVR 605
Cdd:TIGR00110 512 -RYVKGYLAKYAKLVSSADEGAVL 534
 
Name Accession Description Interval E-value
PRK12448 PRK12448
dihydroxy-acid dehydratase; Provisional
2-612 0e+00

dihydroxy-acid dehydratase; Provisional


Pssm-ID: 237104  Cd Length: 615  Bit Score: 1393.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550    2 PDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDD 81
Cdd:PRK12448   1 PKYRSRTTTHGRNMAGARALWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   82 GIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLAS--HG 159
Cdd:PRK12448  81 GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDkiIK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  160 LDLVDAMVVAADDSCSDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGRLAVE 239
Cdd:PRK12448 161 LDLVDAMVAAADPSVSDEDVAQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATHADRKQLFLEAGRRIVE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  240 LCQRYYGEGDDSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPNIQKY 319
Cdd:PRK12448 241 LAKRYYEQDDESVLPRSIATKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEVDFTMADIDRLSRKVPCLCKVAPNTQKY 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  320 HMEDVHRAGGIFSILGELARGGLLHTDVPTVHSPSMADAIAQWDITQTRDEAVHTFFKAGPAGIPTQTAFSQNTRWPSLD 399
Cdd:PRK12448 321 HMEDVHRAGGIMGILGELDRAGLLHTDVPTVHGLTLGEALDQWDIMRTQDEAVKEFFRAAPGGIRTTVAFSQDCRWDSLD 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  400 DDRAEGCIRSVEHAYSKEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDAAVKGILGDEVKAGDIVIIRYE 479
Cdd:PRK12448 401 TDRENGCIRSVEHAYSKDGGLAVLYGNIAEDGCIVKTAGVDESILKFTGPARVFESQDDAVEAILGGKVKAGDVVVIRYE 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  480 GPKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLVS 559
Cdd:PRK12448 481 GPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGAIGLVEDGDIIEIDIPNRSINLLVS 560
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15595550  560 DEELAARRAEQDKKG---WKPaAPRARRVSTALKAYALLATSADKGAVRNKALLDG 612
Cdd:PRK12448 561 DEELAARRAAQEARGdkaWKP-KNRERKVSFALKAYAALATSADKGAVRDKSKLGG 615
IlvD COG0129
Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, ...
1-607 0e+00

Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; Dihydroxyacid dehydratase/phosphogluconate dehydratase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439899  Cd Length: 558  Bit Score: 1029.57  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   1 MPDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVD 80
Cdd:COG0129   1 MPKMRSDTVTKGRERAPARALLRATGLTDEDFGKPIIGIANSWNEIVPGHVHLDDLAEAVKEGIRAAGGVPFEFNTIAVS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  81 DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKlashG- 159
Cdd:COG0129  81 DGIAMGHEGMRYSLPSRELIADSIETMVNAHCFDGLVCIPGCDKITPGMLMAAARLNIPSIFVYGGPMLPGKYD----Gk 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550 160 ----LDLVDAMVVAADDSCSDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGR 235
Cdd:COG0129 157 dldiVDVFEAVGAYAAGKISDEELKEIERNACPGCGSCSGMFTANTMACLTEALGLSLPGSGTIPAVSAERRRLAREAGR 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550 236 LAVELCQRyygegddSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPN 315
Cdd:COG0129 237 RIVELVEK-------DIKPRDILTREAFENAIAVDMALGGSTNTVLHLLAIAHEAGVDLTLDDFDRISRRTPHLCDLKPS 309
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550 316 IqKYHMEDVHRAGGIFSILGELARGGLLHTDVPTVHSPSMADAIAQWDItqtrdeavhtffkagpagiptqtafsqntrw 395
Cdd:COG0129 310 G-KYHMEDLHRAGGIPAVMKELLDAGLLHGDCLTVTGKTLAENLADADI------------------------------- 357
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550 396 pslddDRAEGCIRSVEHAYSKEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDAAVKGILGDEVKAGDIVI 475
Cdd:COG0129 358 -----DRDQDVIRPLDNPYSPTGGLAILRGNLAPDGAVVKTAGVDESMLVFEGPARVFDSEEEAVEAILGGKIKAGDVVV 432
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550 476 IRYEGPKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSIN 555
Cdd:COG0129 433 IRYEGPKGGPGMREMLSPTSALKGMGLGKSVALITDGRFSGGTRGLSIGHVSPEAAEGGPIALVEDGDIITIDIPARTLD 512
                       570       580       590       600       610
                ....*....|....*....|....*....|....*....|....*....|..
gi 15595550 556 LLVSDEELAARRAEqdkkgWKPaaPRARRVSTALKAYALLATSADKGAVRNK 607
Cdd:COG0129 513 LLVSDEELARRRAA-----WKP--PEPRVTSGVLAKYAKLVSSASKGAVTDP 557
ILVD_EDD pfam00920
Dehydratase family;
34-603 0e+00

Dehydratase family;


Pssm-ID: 459998  Cd Length: 513  Bit Score: 863.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550    34 KPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCA 113
Cdd:pfam00920   1 KPIIGIANSYSDLVPCHVHLRELAEAVKEGVREAGGVPAEFNTIGVCDGIAMGHEGMRYSLPSRELIADSIEEMLRAHPF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   114 DAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKtklasHGLDLVDAMVVAADDSCSDEKVAEYERSACPTCGSC 193
Cdd:pfam00920  81 DGLVLIGGCDKIVPGMLMAAARLNIPAIFVSGGPMLPGG-----SGTDEFEAVGAYAAGKISEEELLEIERAACPGCGSC 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   194 SGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGRLAVELCQRyygegddSVLPRNIANFKAFENAMTLDIAM 273
Cdd:pfam00920 156 GGMGTANTMACLAEALGLSLPGSATIPAVSAERLRLAREAGRRIVELVEE-------DIKPRDILTRKAFENAIVVDMAL 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   274 GGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPNiQKYHMEDVHRAGGIFSILGELARgGLLHTDVPTVHSP 353
Cdd:pfam00920 229 GGSTNAVLHLLAIAREAGVDLTLDDFDRISRKVPLLADLKPS-GKYLMEDFHRAGGVPAVLKELLD-ALLHGDVLTVTGK 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   354 SMADAIAQwditqtrdeavhtffkagpagiptqtafsqntrwpslDDDRAEGCIRSVEHAYSKEGGLAVLYGNIALDGCV 433
Cdd:pfam00920 307 TLGENLAD-------------------------------------AEVRDQDVIRPLDNPISPTGGLAVLKGNLAPDGAV 349
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   434 VKTAGVDESIHVFEGSAKIFESQDAAVKGILGDEVKAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGR 513
Cdd:pfam00920 350 VKTSAVDPEMLVFEGPARVFDSEEDALAAILDGKIKAGDVVVIRYEGPKGGPGMPEMLTPTSALLGAGLGKDVALITDGR 429
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   514 FSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLVSDEELAARRAEqdkkgWKPAAPRARRvSTALKAYA 593
Cdd:pfam00920 430 FSGASRGPSIGHVSPEAAVGGPIALVRDGDIIRIDIPNRTLDLLVSDEELAARRAA-----WKPPEPKVKG-RGYLAKYA 503
                         570
                  ....*....|
gi 15595550   594 LLATSADKGA 603
Cdd:pfam00920 504 KLVSSASEGA 513
ilvD TIGR00110
dihydroxy-acid dehydratase; This protein, dihydroxy-acid dehydratase, catalyzes the fourth ...
24-605 0e+00

dihydroxy-acid dehydratase; This protein, dihydroxy-acid dehydratase, catalyzes the fourth step in valine and isoleucine biosynthesis. It contains a catalytically essential [4Fe-4S] cluster This model generates scores of up to 150 bits vs. 6-phosphogluconate dehydratase, a homologous enzyme. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272910  Cd Length: 535  Bit Score: 824.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550    24 ATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADS 103
Cdd:TIGR00110   1 ATGFTDEDFGKPFIGVANSYTTIVPGHMHLRDLAQAVKEGIEAAGGVAFEFNTIAVCDGIAMGHEGMKYSLPSREIIADS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   104 VEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLASH--GLDLVDAMVVAADDSCSDEKVAE 181
Cdd:TIGR00110  81 VETMVNAHRFDGLVCIPSCDKITPGMLMAAARLNIPSIFVTGGPMLPGHTKLGKKidLVSAFEAVGEYAAGKISEEELEE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   182 YERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGRLAVELCQRYYgegddsvLPRNIANFK 261
Cdd:TIGR00110 161 IERSACPGCGSCSGMFTANTMACLTEALGLSLPGCSTMLATSAEKKRIAKNSGKRIVELVKKNI-------KPRDILTKE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   262 AFENAMTLDIAMGGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPNIQKYhMEDVHRAGGIFSILGELARGG 341
Cdd:TIGR00110 234 AFENAITVDMALGGSTNTVLHLLAIANEAGVDLSLDDFDRLSRKVPHIASLAPSGKYV-MEDLHRAGGIPAVLKELDREG 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   342 LLHTDVPTVHSPSMADAIAQWDITQTRDEavhtffkagpagiptqtafsqntrwpsldddraegCIRSVEHAYSKEGGLA 421
Cdd:TIGR00110 313 LLHGDTLTVTGKTLGEILEQAPVIPEGQD-----------------------------------VIRPLDNPVHQEGGLA 357
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   422 VLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDAAVKGILGDEVKAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKG 501
Cdd:TIGR00110 358 ILKGNLAPNGAVVKIAGVDEDMTKFEGPAKVFESEEEALEAILGGKIKEGDVVVIRYEGPKGGPGMPEMLAPTSAIKGMG 437
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   502 LGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLVSDEELAARRAEQDKKGWkpaapr 581
Cdd:TIGR00110 438 LGKSVALITDGRFSGGTRGLCIGHVSPEAAEGGPIALVEDGDIIIIDIPNRKLDLQVSDEELAERRASWKAPEP------ 511
                         570       580
                  ....*....|....*....|....
gi 15595550   582 aRRVSTALKAYALLATSADKGAVR 605
Cdd:TIGR00110 512 -RYVKGYLAKYAKLVSSADEGAVL 534
PRK00911 PRK00911
dihydroxy-acid dehydratase; Provisional
5-604 0e+00

dihydroxy-acid dehydratase; Provisional


Pssm-ID: 234861  Cd Length: 552  Bit Score: 799.66  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550    5 RSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDDGIA 84
Cdd:PRK00911   2 RSDMITKGVERAPHRSMLRATGLTDEDFDKPFIGIANSWNEITPCNIHLNELADAVKEGVRAAGGVPFEFNTIGVSDGIA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   85 MGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKtklaSHG--LDL 162
Cdd:PRK00911  82 MGHEGMKYSLVSREVIADSIETVVNAHWFDGLVAIPGCDKNMPGMLMAAARLNVPSIFVYGGPILPGR----LKGkdLTL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  163 VDA--MV--VAADDsCSDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGRLAV 238
Cdd:PRK00911 158 VSVfeAVgaYAAGK-ISEEELKEIERNACPGAGSCGGMFTANTMACLIEALGMSLPGSGTIPAVDAERDELAREAGEAVV 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  239 ELCQRyygegddSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPNiQK 318
Cdd:PRK00911 237 ELLEK-------DIKPRDILTREAFENAIAVDMALGGSTNAVLHLLAIAHEAGVDLTLDDFNRISKRTPHLADLKPS-GK 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  319 YHMEDVHRAGGIFSILGELARGGLLHTDVPTVHSPSMADAIAqwditqtrdeavhtffkagpagiptqtafsqntRWPSL 398
Cdd:PRK00911 309 YVMEDLHEAGGIPAVMKELLDAGLLHGDCLTVTGKTLAENLA---------------------------------DAPDP 355
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  399 DDDraegCIRSVEHAYSKEGGLAVLYGNIALDGCVVKTAGVDESihVFEGSAKIFESQDAAVKGILGDEVKAGDIVIIRY 478
Cdd:PRK00911 356 DQD----VIRPLDNPISPTGGLAILKGNLAPEGAVVKIAGVKPE--MFTGPARVFDSEEEAMEAILAGKIKAGDVVVIRY 429
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  479 EGPKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLV 558
Cdd:PRK00911 430 EGPKGGPGMREMLAPTSAIVGAGLGDDVALITDGRFSGGTRGLCVGHVSPEAAVGGPIALVEDGDIITIDAPNRTLDVLV 509
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*.
gi 15595550  559 SDEELAARRAEqdkkgWKPAAPRARRvsTALKAYALLATSADKGAV 604
Cdd:PRK00911 510 SDEELARRRAA-----WKPPEPKYKR--GVLAKYAKLVSSASTGAV 548
PRK06131 PRK06131
dihydroxy-acid dehydratase; Validated
5-603 8.43e-122

dihydroxy-acid dehydratase; Validated


Pssm-ID: 235708  Cd Length: 571  Bit Score: 372.21  E-value: 8.43e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550    5 RSKTS--THGRNMAGARALWRATGMKDEDFK-KPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVdd 81
Cdd:PRK06131   6 RSLAWfgDDDFRAFYHRSFMKNQGYPDELFDgRPIIGICNTWSDLNPCNAHFRQLAERVKRGVLEAGGFPVEFPVISL-- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   82 giamGHDG-----MLYslpsREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKla 156
Cdd:PRK06131  84 ----GESFlrptaMLY----RNLAAMDVEEMIRGYPIDGVVLLGGCDKTTPALLMGAASVDLPAIVLSGGPMLNGKHK-- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  157 shGLDLvdamvvaadDSCSD---------------EKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLA 221
Cdd:PRK06131 154 --GERL---------GSGTDvwkyweelrageidlEEFLEAEAGMARSAGTCNTMGTASTMACMAEALGMSLPGNAAIPA 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  222 THADREQLFLRAGRLAVELCqryygegDDSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVPFDLRDIDR 301
Cdd:PRK06131 223 VDARRIRMAELTGRRIVEMV-------HEDLKPSDILTREAFENAIRVNAAIGGSTNAVIHLIAIAGRAGVELDLDDWDR 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  302 LSRKVPQLCkvapNIQ---KYHMEDVHRAGGIFSILGELarGGLLHTDVPTVHSPSMADAIAQWDITqtrDEAVhtffka 378
Cdd:PRK06131 296 IGRDVPVLV----NLQpsgEYLMEDFYYAGGLPAVLREL--GELLHLDALTVNGKTLGENLAGAPVY---NDDV------ 360
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  379 gpagiptqtafsqntrwpsldddraegcIRSVEHAYSKEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDA 458
Cdd:PRK06131 361 ----------------------------IRPLDNPLKPEGGIAVLRGNLAPDGAVIKPSAASPELLKHEGRAVVFEGYED 412
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  459 AVKGIlGDE---VKAGDIVIIRYEGPKGGPGMQE--MLYPTSYLKSKGLgKQCALLTDGRFSGGTSGLSIGHASPEAAAG 533
Cdd:PRK06131 413 YKARI-DDPdldVDEDTVLVLRNAGPKGYPGMPEvgNMPIPKKLLRQGV-KDMVRISDARMSGTAYGTVVLHVAPEAAAG 490
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  534 GAIGLVQDGDKVLIDIPNRSINLLVSDEELAARRAEqdkkgWKPAAPRARRVSTALkaYALLATSADKGA 603
Cdd:PRK06131 491 GPLALVRTGDRIRLDVPARRLDLLVSDEELARRRAA-----WPPPPPRAERGYQEL--YRDHVLQADEGC 553
PRK13016 PRK13016
dihydroxy-acid dehydratase; Provisional
26-603 1.39e-107

dihydroxy-acid dehydratase; Provisional


Pssm-ID: 237271  Cd Length: 577  Bit Score: 335.54  E-value: 1.39e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   26 GMKDEDFK-KPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDDGIaMGHDGMLYslpsREIIADSV 104
Cdd:PRK13016  33 GYAPEDFDgKPVIAILNTWSDANPCHGHFRERVEDVKRGVLQAGGFPLELPALSLSENF-VKPTTMLY----RNLLAMET 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  105 EYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAG--KTKLASHGLDLVD--AMVVAAddSCSDEKVA 180
Cdd:PRK13016 108 EELIRSHPVDGAVLMGGCDKTTPGLVMGAISMGLPMIYLPAGPMLRGnyRGKVLGSGSDAWKywDERRAG--NITQAEWL 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  181 EYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGRLAVELCQryygegdDSVLPRNIANF 260
Cdd:PRK13016 186 EIEGGIARSYGTCMTMGTASTMTAIAEALGLTLPGASSIPAADANHQRMAALCGRRIVEMVW-------EDLTPSQILTK 258
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  261 KAFENAMTLDIAMGGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPNIQKYHMEDVHRAGGIFSILGELarG 340
Cdd:PRK13016 259 AAFENAITVAMATGCSTNAVIHLIAMARRAGVPLSLDDLDRCGRTVPVIANIRPSGKTYLMEDFFYAGGLRALMKQL--G 336
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  341 GLLHTDVPTVHSPSMADAIAqwditqtrDEAVHtffkagpagiptqtafsqntrwpslDDDraegCIRSVEHAYSKEGGL 420
Cdd:PRK13016 337 DKLHLDALTVTGKTLGDNLE--------GAKVY-------------------------NDD----VIRPLDNPVYAEGSL 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  421 AVLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDaAVKGILGDE---VKAGDIVIIRYEGPKGGPGMQE--ML-YPT 494
Cdd:PRK13016 380 AVLRGNLAPDGAVIKPAACDPKFLVHRGPALVFDSYP-EMKAAIDDEnldVTPDHVMVLRNAGPQGGPGMPEwgMLpIPK 458
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  495 SYLKsKGLgKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLVSDEELAARRAEqdkkg 574
Cdd:PRK13016 459 KLLK-QGV-RDMVRISDARMSGTSYGACVLHVAPEAYVGGPLALVRTGDIIELDVPARRLHLLVSDEELARRRAA----- 531
                        570       580       590
                 ....*....|....*....|....*....|...
gi 15595550  575 WKPAAPRARRvstalkAYALLA----TSADKGA 603
Cdd:PRK13016 532 WQPPERRYER------GYGWMFsqhvEQADKGC 558
PRK13017 PRK13017
dihydroxy-acid dehydratase; Provisional
34-584 1.49e-106

dihydroxy-acid dehydratase; Provisional


Pssm-ID: 237272  Cd Length: 596  Bit Score: 333.47  E-value: 1.49e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550   34 KPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFN-----------TIAVDDGIA-MGHDGMLYSLPsreiia 101
Cdd:PRK13017  47 KPIIGIAQTGSDLSPCNRHHLELAERVKEGIRDAGGIPMEFPvhpiqetgkrpTAALDRNLAyLGLVEILYGYP------ 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  102 dsveymvnahcADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAG--KTKLASHGLDLVDAMVVAADDSCSDEKV 179
Cdd:PRK13017 121 -----------LDGVVLTTGCDKTTPACLMAAATVDLPAIVLSGGPMLDGwhEGERVGSGTVIWKARELLAAGEIDYEEF 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  180 AEYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGRLAVELCQryygegdDSVLPRNIAN 259
Cdd:PRK13017 190 MELVASSAPSVGHCNTMGTASTMNALAEALGMSLPGCAAIPAPYRERGQMAYATGKRIVEMVW-------EDLKPSDILT 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  260 FKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPNiQKYHMEDVHRAGGIFSILGELAR 339
Cdd:PRK13017 263 REAFENAIVVNSAIGGSTNAPIHLIAIARHAGVELSLDDWQRVGEDVPLLVNLQPA-GKYLGEDFHRAGGVPAVLAELLR 341
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  340 GGLLHTDVPTVHSPSMADAIAQwdiTQTRDEAVhtffkagpagiptqtafsqntrwpsldddraegcIRSVEHAYSKEGG 419
Cdd:PRK13017 342 AGLLHGDALTVSGRTIGENIAG---APAPDRDV----------------------------------IRPYDAPLKERAG 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  420 LAVLYGNIAlDGCVVKTAGVDE-----------SIHVFEGSAKIFES--------QDAAVkgilgdEVKAGDIVIIRYEG 480
Cdd:PRK13017 385 FLVLRGNLF-DSAIMKTSVISEefrerylsepgDENAFEGRAVVFDGpedyhariDDPAL------DIDEHCILVIRGAG 457
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595550  481 PKGGPGMQE--MLYPTSYLKSKGLgKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLV 558
Cdd:PRK13017 458 PVGYPGSAEvvNMQPPAALLKRGI-RSLPCIGDGRQSGTSGSPSILNASPEAAVGGGLALLRTGDRIRIDLNKRRVDVLV 536
                        570       580
                 ....*....|....*....|....*.
gi 15595550  559 SDEELAARRAEqdkkgWKPAAPRARR 584
Cdd:PRK13017 537 SDEELARRRAA-----LKPPVPPSQT 557
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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