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Conserved domains on  [gi|15595732|ref|NP_249226|]
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transcriptional regulator [Pseudomonas aeruginosa PAO1]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 14302692)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator containing a cupin-like domain, controls the expression of genes involved in stress response

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|15808743|10556324|14697267

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_XRE_C cd02209
XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; ...
 95-182 1.09e-17

XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


:

Pssm-ID: 380339 [Multi-domain]  Cd Length: 90  Bit Score: 73.70  E-value: 1.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732  95 GASDNLVSPRL-GGAFFMLETCLEAGADSGErdlLDS--SEQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYAN 171
Cdd:cd02209   1 GYTYELLSPGLpGRKMEPFLVTLPPGGSGGE---PYSheGEEFGYVLEGELELTVGGETYVLEAGDSIYFDSDVPHRYRN 77

                        90
                ....*....|.
gi 15595732 172 RSQAPVRVLWV 182
Cdd:cd02209  78 PGDEPARVLWV 88
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
5-70 2.99e-14

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 64.63  E-value: 2.99e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15595732   5 ADDLAEIASLVRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLGVPATYFF 70
Cdd:COG1396   2 STLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELL 67
 
Name Accession Description Interval E-value
cupin_XRE_C cd02209
XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; ...
 95-182 1.09e-17

XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380339 [Multi-domain]  Cd Length: 90  Bit Score: 73.70  E-value: 1.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732  95 GASDNLVSPRL-GGAFFMLETCLEAGADSGErdlLDS--SEQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYAN 171
Cdd:cd02209   1 GYTYELLSPGLpGRKMEPFLVTLPPGGSGGE---PYSheGEEFGYVLEGELELTVGGETYVLEAGDSIYFDSDVPHRYRN 77

                        90
                ....*....|.
gi 15595732 172 RSQAPVRVLWV 182
Cdd:cd02209  78 PGDEPARVLWV 88
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
95-184 2.17e-16

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 71.20  E-value: 2.17e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732  95 GASDNLVSPRLGG-AFFMLETCLEAGADSGERDLLDSSEQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYANRS 173
Cdd:COG3837  13 GRRYRRLGDALGLtRLGVNLITLPPGASSSPYHAHSAEEEFVYVLEGELTLRIGGEEYVLEPGDSVGFPAGVPHRLRNRG 92

                        90
                ....*....|.
gi 15595732 174 QAPVRVLWVYA 184
Cdd:COG3837  93 DEPARYLVVGT 103
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 115-183 4.70e-16

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 68.82  E-value: 4.70e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15595732   115 CLEAGAdSGERDLLDSSEQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYANRSQAPVRVLWVY 183
Cdd:pfam07883   4 TLPPGE-SSPPHRHPGEDEFFYVLEGEGELTVDGEEVVLKAGDSVYFPAGVPHRFRNTGDEPARLLDVY 71
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
5-70 2.99e-14

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 64.63  E-value: 2.99e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15595732   5 ADDLAEIASLVRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLGVPATYFF 70
Cdd:COG1396   2 STLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELL 67
PRK09943 PRK09943
HTH-type transcriptional regulator PuuR;
17-180 6.59e-12

HTH-type transcriptional regulator PuuR;


Pssm-ID: 182158 [Multi-domain]  Cd Length: 185  Bit Score: 60.96  E-value: 6.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732   17 ELRKRKGITLQALAD--GIRRSVgfVSQVERGLSRPAVDDLVAISQVLGVPATYFFCSPKIQASPWVTRPGERRTLAYAR 94
Cdd:PRK09943  14 EIRQQQGLSQRRAAElsGLTHSA--ISTIEQDKVSPAISTLQKLLKVYGLSLSEFFSEPEKPDEPQVVINQDDLIEMGSQ 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732   95 GASDNLV---SPR--LGgafFMLETcLEAGADSGERdLLDSSEQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRY 169
Cdd:PRK09943  92 GVSMKLVhngNPNrtLA---MIFET-YQPGTTTGER-IKHQGEEIGTVLEGEIVLTINGQDYHLVAGQSYAINTGIPHSF 166

                        170
                 ....*....|.
gi 15595732  170 ANRSQAPVRVL 180
Cdd:PRK09943 167 SNTSAGICRII 177
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 12-69 1.10e-10

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 54.48  E-value: 1.10e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15595732  12 ASLVRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLGVPATYF 69
Cdd:cd00093   1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
15-69 2.46e-10

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 53.68  E-value: 2.46e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 15595732     15 VRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLGVPATYF 69
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 15-69 7.75e-10

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 52.16  E-value: 7.75e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15595732    15 VRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLGVPATYF 69
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
couple_hipB TIGR03070
transcriptional regulator, y4mF family; Members of this family belong to a clade of ...
 10-63 2.54e-05

transcriptional regulator, y4mF family; Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions]


Pssm-ID: 213767 [Multi-domain]  Cd Length: 58  Bit Score: 40.34  E-value: 2.54e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15595732    10 EIASLVRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLG 63
Cdd:TIGR03070   2 QIGILVRARRKALGLTQADLADLAGVGLRFIRDLENGKPTVRLDKVLRVLDALG 55
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 15-68 2.53e-04

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 39.45  E-value: 2.53e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15595732   15 VRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLGVPATY 68
Cdd:PRK09706  10 IRYRRKQLKLSQRSLAKAVKVSHVSISQWERDETEPTGKNLFALAKALQCSPTW 63
 
Name Accession Description Interval E-value
cupin_XRE_C cd02209
XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; ...
 95-182 1.09e-17

XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380339 [Multi-domain]  Cd Length: 90  Bit Score: 73.70  E-value: 1.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732  95 GASDNLVSPRL-GGAFFMLETCLEAGADSGErdlLDS--SEQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYAN 171
Cdd:cd02209   1 GYTYELLSPGLpGRKMEPFLVTLPPGGSGGE---PYSheGEEFGYVLEGELELTVGGETYVLEAGDSIYFDSDVPHRYRN 77

                        90
                ....*....|.
gi 15595732 172 RSQAPVRVLWV 182
Cdd:cd02209  78 PGDEPARVLWV 88
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
95-184 2.17e-16

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 71.20  E-value: 2.17e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732  95 GASDNLVSPRLGG-AFFMLETCLEAGADSGERDLLDSSEQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYANRS 173
Cdd:COG3837  13 GRRYRRLGDALGLtRLGVNLITLPPGASSSPYHAHSAEEEFVYVLEGELTLRIGGEEYVLEPGDSVGFPAGVPHRLRNRG 92

                        90
                ....*....|.
gi 15595732 174 QAPVRVLWVYA 184
Cdd:COG3837  93 DEPARYLVVGT 103
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 115-183 4.70e-16

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 68.82  E-value: 4.70e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15595732   115 CLEAGAdSGERDLLDSSEQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYANRSQAPVRVLWVY 183
Cdd:pfam07883   4 TLPPGE-SSPPHRHPGEDEFFYVLEGEGELTVDGEEVVLKAGDSVYFPAGVPHRFRNTGDEPARLLDVY 71
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
5-70 2.99e-14

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 64.63  E-value: 2.99e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15595732   5 ADDLAEIASLVRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLGVPATYFF 70
Cdd:COG1396   2 STLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELL 67
PRK09943 PRK09943
HTH-type transcriptional regulator PuuR;
17-180 6.59e-12

HTH-type transcriptional regulator PuuR;


Pssm-ID: 182158 [Multi-domain]  Cd Length: 185  Bit Score: 60.96  E-value: 6.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732   17 ELRKRKGITLQALAD--GIRRSVgfVSQVERGLSRPAVDDLVAISQVLGVPATYFFCSPKIQASPWVTRPGERRTLAYAR 94
Cdd:PRK09943  14 EIRQQQGLSQRRAAElsGLTHSA--ISTIEQDKVSPAISTLQKLLKVYGLSLSEFFSEPEKPDEPQVVINQDDLIEMGSQ 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732   95 GASDNLV---SPR--LGgafFMLETcLEAGADSGERdLLDSSEQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRY 169
Cdd:PRK09943  92 GVSMKLVhngNPNrtLA---MIFET-YQPGTTTGER-IKHQGEEIGTVLEGEIVLTINGQDYHLVAGQSYAINTGIPHSF 166

                        170
                 ....*....|.
gi 15595732  170 ANRSQAPVRVL 180
Cdd:PRK09943 167 SNTSAGICRII 177
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 12-69 1.10e-10

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 54.48  E-value: 1.10e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15595732  12 ASLVRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLGVPATYF 69
Cdd:cd00093   1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
101-184 1.43e-10

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 55.92  E-value: 1.43e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732 101 VSPRLGGAFFMLETCLEAGADSGERDLLDSSEqGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYANRSQAPVRVL 180
Cdd:COG0662  19 VLGEGGERLSVKRITVPPGAELSLHVHPHRDE-FFYVLEGTGEVTIGDEEVELKAGDSVYIPAGVPHRLRNPGDEPLELL 97


                ....
gi 15595732 181 WVYA 184
Cdd:COG0662  98 EVQA 101
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
15-69 2.46e-10

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 53.68  E-value: 2.46e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 15595732     15 VRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLGVPATYF 69
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 15-69 7.75e-10

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 52.16  E-value: 7.75e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15595732    15 VRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLGVPATYF 69
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
10-70 1.06e-09

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 52.16  E-value: 1.06e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15595732  10 EIASLVRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLGVPATYFF 70
Cdd:COG1476   4 KLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELF 64
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
132-184 4.03e-09

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 51.77  E-value: 4.03e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 15595732 132 EQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYANRSQAPVRVLWVYA 184
Cdd:COG1917  44 EELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFRNLGDEPAVLLVVFS 96
cupin_TcmJ-like cd06991
TcmJ monooxygenase and related proteins, cupin domain; This family includes TcmJ, a subunit of ...
 100-179 4.68e-09

TcmJ monooxygenase and related proteins, cupin domain; This family includes TcmJ, a subunit of the tetracenomycin (TCM) polyketide synthase (PKS) type II complex in Streptomyces glaucescens. TcmJ is a quinone-forming monooxygenase involved in the modification of aromatic polyketides synthesized by polyketide synthases of types II and III. Orthologs of TcmJ include the Streptomyces BenD (benastatin biosynthetic pathway), the Streptomyces olivaceus ElmJ (polyketide antibiotic elloramycin biosynthetic pathway), the Actinomadura hibisca PdmL (pradimicin biosynthetic pathway), the Streptomyces cyaneus CurC (curamycin biosynthetic pathway), the Streptomyces rishiriensis Lct30 (lactonamycin biosynthetic pathway), and the Streptomyces WhiE II (spore pigment polyketide biosynthetic pathway). Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380396 [Multi-domain]  Cd Length: 105  Bit Score: 51.53  E-value: 4.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732 100 LVSPRLGGAF--FMLETCLEAGADSGERdLLDSSEQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYANRSQAPV 177
Cdd:cd06991   8 LLSPKTVGATsgFMGTLTLAPGERVSEH-YHPYSEEFLYVVRGRLVVRVDGEPVVLEAGEALLVPRGVRHRLENAGDEPA 86


                ..
gi 15595732 178 RV 179
Cdd:cd06991  87 RL 88
AllE COG3257
Ureidoglycine aminohydrolase [Nucleotide transport and metabolism];
100-182 5.14e-09

Ureidoglycine aminohydrolase [Nucleotide transport and metabolism];


Pssm-ID: 442488 [Multi-domain]  Cd Length: 262  Bit Score: 54.06  E-value: 5.14e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732 100 LVSPRLGGAF--FMLETCLEAGADSGERDllDSSEQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYANRSQAPV 177
Cdd:COG3257  50 LARPLSGATFsqYIVEVAPGGGSDRPEPD--PGAETFLFVLEGEVTLTLGGETHELTPGGYAYLPPGTPWTLRNAGDEPA 127


                ....*
gi 15595732 178 RVLWV 182
Cdd:COG3257 128 RFHWI 132
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 1-68 8.54e-09

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 49.94  E-value: 8.54e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15595732   1 MSEVADDLAEIaslVRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLGVPATY 68
Cdd:COG1813   6 TGELVEDYGER---IREAREARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALGISLAE 70
cupin_KdgF cd02238
pectin degradation protein KdgF and related proteins, cupin domain; This family includes ...
 132-165 3.07e-08

pectin degradation protein KdgF and related proteins, cupin domain; This family includes bacterial and archaeal pectin degradation protein KdgF that catalyzes the linearization of unsaturated uronates from both pectin and alginate, which are polysaccharides found in the cell walls of plants and brown algae, respectively, and represent an important source of carbon. These polysaccharides, mostly consisting of chains of uronates, can be metabolized by bacteria through a pathway of enzymatic steps to the key metabolite 2-keto-3-deoxygluconate (KDG). Pectin degradation is used by many plant-pathogenic bacteria during infection, and also, pectin and alginate can both represent abundant sources of carbohydrate for the production of biofuels. These proteins belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380366 [Multi-domain]  Cd Length: 104  Bit Score: 49.39  E-value: 3.07e-08
                        10        20        30
                ....*....|....*....|....*....|....
gi 15595732 132 EQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHM 165
Cdd:cd02238  48 EQIGYVLSGRFEFTIGGETRILKPGDSYYIPPNV 81
PRK11171 PRK11171
(S)-ureidoglycine aminohydrolase;
100-182 5.79e-08

(S)-ureidoglycine aminohydrolase;


Pssm-ID: 183011 [Multi-domain]  Cd Length: 266  Bit Score: 51.05  E-value: 5.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732  100 LVSPRLGGAF--FMLETCLEAGADSGERDllDSSEQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYANRSQAPV 177
Cdd:PRK11171  52 LARPGLGATFsqYLVEVEPGGGSDQPEPD--EGAETFLFVVEGEITLTLEGKTHALSEGGYAYLPPGSDWTLRNAGAEDA 129


                 ....*
gi 15595732  178 RVLWV 182
Cdd:PRK11171 130 RFHWI 134
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 129-183 2.70e-07

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 45.94  E-value: 2.70e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15595732 129 DSSEQGGYVLEGELTLWLED-EELRLQAGDGFQIPSHMRSRYANRSQAPVRVLWVY 183
Cdd:cd02208  18 PEQDEIFYVLSGEGELTLDDgETVELKAGDIVLIPPGVPHSFVNTSDEPAVFLVVS 73
cupin_UGlyAH_N cd02211
(S)-ureidoglycine aminohydrolase and related proteins, N-terminal cupin domain; This family ...
 100-182 2.13e-06

(S)-ureidoglycine aminohydrolase and related proteins, N-terminal cupin domain; This family includes the N-terminal cupin domain of (S)-ureidoglycine aminohydrolase (UGlyAH), an enzyme that converts (S)-ureidoglycine into (S)-ureidoglycolate and ammonia, providing the final substrate to the ureide pathway. The ureide pathway has recently been identified as the metabolic route of purine catabolism in plants and some bacteria where, uric acid, which is a major product of the early stage of purine catabolism, is degraded into glyoxylate and ammonia via stepwise reactions by seven different enzymes. Thus, this pathway has a possible physiological role in mobilization of purine ring nitrogen for further assimilation. This enzyme from Arabidopsis thaliana(AtUGlyAH) has been shown to bind a Mn2+ ion, via the C-terminal cupin domain, which acts as a molecular anchor to bind (S)-ureidoglycine, and its binding mode dictates the enantioselectivity of the reaction. The structure of AtUGlyAH shows a bi-cupin fold with a conserved "jelly roll-like" beta-barrel fold and an octameric functional unit. Several structural homologs of UGlyAH, including the Escherichia coli ortholog YlbA (also known as GlxB6), also exhibit similar features.


Pssm-ID: 380341 [Multi-domain]  Cd Length: 117  Bit Score: 44.82  E-value: 2.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732 100 LVSPRLGGAF--FMLEtcLEAGA--DSGERDllDSSEQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYANRSQA 175
Cdd:cd02211  16 LASPKLGATFvqYLVE--VEPGGgsTAPEGG--EGIERFLYVLEGEVELTVGGETHTLTAGGYAYLPPGTKHSLRNAGDE 91


                ....*..
gi 15595732 176 PVRVLWV 182
Cdd:cd02211  92 PARLLWY 98
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 15-70 2.21e-06

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 43.43  E-value: 2.21e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15595732    15 VRELRKRKGITLQALAD--GIRRSvgFVSQVERGLSRPAVDDLVAISQVLGVPATYFF 70
Cdd:pfam12844   4 LRKAREERGLTQEELAErlGISRS--QLSAIENGKSVPPAETLYKIAELLGVPANWLL 59
cupin_SPO2919-like cd02224
Silicibacter pomeroyi SPO2919 and related proteins, uncharacterized sugar phosphate isomerase ...
 136-180 5.15e-06

Silicibacter pomeroyi SPO2919 and related proteins, uncharacterized sugar phosphate isomerase with a cupin domain; This family includes proteins similar to sugar phosphate isomerase SPO2919 from Silicibacter pomeroyi and Afe_0303 from Acidithiobacillus ferrooxidans, but are as yet uncharacterized. Structures of these proteins show a cupin fold with a conserved "jelly roll-like" beta-barrel fold that form a homodimer.


Pssm-ID: 380353 [Multi-domain]  Cd Length: 105  Bit Score: 43.24  E-value: 5.15e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 15595732 136 YVLEGELTLWLEDEELRLQAGD------GFQIPSHMRsryaNRSQAPVRVL 180
Cdd:cd02224  44 YVLSGEGTLRLDGEEVLPRPGDfvgfpaGTGVAHQLI----NRSDEPLVYL 90
cupin_BLL4011-like cd02235
Bradyrhizobium diazoefficiens BLL4011 and related proteins, cupin domain; This family includes ...
 135-183 1.44e-05

Bradyrhizobium diazoefficiens BLL4011 and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to BLL4011, a Bradyrhizobium diazoefficiens protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380363 [Multi-domain]  Cd Length: 100  Bit Score: 42.18  E-value: 1.44e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 15595732 135 GYVLEGELTLWLEDE-ELRLQAGDGFQIPSHMRSRYANRSQAPVRVLWVY 183
Cdd:cd02235  43 GYVLEGSLELEVDGQpPVTLKAGDSFFIPAGTVHNAKNVGSGPAKLLATY 92
couple_hipB TIGR03070
transcriptional regulator, y4mF family; Members of this family belong to a clade of ...
 10-63 2.54e-05

transcriptional regulator, y4mF family; Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions]


Pssm-ID: 213767 [Multi-domain]  Cd Length: 58  Bit Score: 40.34  E-value: 2.54e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15595732    10 EIASLVRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLG 63
Cdd:TIGR03070   2 QIGILVRARRKALGLTQADLADLAGVGLRFIRDLENGKPTVRLDKVLRVLDALG 55
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 10-65 3.95e-05

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 39.82  E-value: 3.95e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15595732    10 EIASLVRELRKRKGITLQALADGIRRSVGFVSQVERGL-SRPAVDDLVAISQVLGVP 65
Cdd:pfam13560   1 ELGARLRRLRERAGLSQEALARRLGVSRSTLSRLETGRrGRPSPAVVERLARALGVD 57
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 135-183 8.23e-05

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 40.50  E-value: 8.23e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 15595732   135 GYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYANRSQAPVRVLWVY 183
Cdd:pfam02311  27 GYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLY 75
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 15-68 2.53e-04

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 39.45  E-value: 2.53e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15595732   15 VRELRKRKGITLQALADGIRRSVGFVSQVERGLSRPAVDDLVAISQVLGVPATY 68
Cdd:PRK09706  10 IRYRRKQLKLSQRSLAKAVKVSHVSISQWERDETEPTGKNLFALAKALQCSPTW 63
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 9-63 5.65e-04

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 37.69  E-value: 5.65e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15595732   9 AEIASLVRELRKRKGITLQALAD--GIRRSvgFVSQVERGLSRPAVDDLVAISQVLG 63
Cdd:COG3620  16 DTLGEALRLMRKELGLSQLPVAElvGVSQS--DILRIESGKRDPTVSTLEKIAEALG 70
cupin_CV2614-like cd02236
Chromobacterium violaceum CV2614 and related proteins, cupin domain; This family includes ...
 135-184 6.05e-04

Chromobacterium violaceum CV2614 and related proteins, cupin domain; This family includes mostly bacterial proteins homologous to CV2614, a Chromobacterium violaceum protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380364 [Multi-domain]  Cd Length: 102  Bit Score: 37.47  E-value: 6.05e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15595732 135 GYVLEGELTLWLED-EELRLQAGDGF----QIPSHMRsryaNRSQAPVRVLWVYA 184
Cdd:cd02236  46 GYVLSGELTVEYEDgKKRTFKAGDAFveavNTWHRGR----NGGDEPVELLVFYA 96
cupin_BLL6423-like cd02231
Bradyrhizobium japonicum BLL6423 and related proteins, cupin domain; This family includes ...
 135-182 6.44e-04

Bradyrhizobium japonicum BLL6423 and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to BLL6423, a Bradyrhizobium japonicum protein of unknown function; it includes a structure of an uncharacterized protein from Novosphingobium aromaticivorans. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380359  Cd Length: 108  Bit Score: 37.53  E-value: 6.44e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 15595732 135 GYVLEGELTLWLED-EELRLQAGD-----GfqiPSHmrsRYANRSQAPVRVLWV 182
Cdd:cd02231  60 GIVLEGEIELELDDgEEVTLKAGDvvvqrG---TMH---AWRNRSDEPARMAFV 107
cupin_YP766765-like cd20299
Rhizobium leguminosarum YP_766765.1 and related proteins, cupin domain; This family includes ...
 136-184 7.83e-04

Rhizobium leguminosarum YP_766765.1 and related proteins, cupin domain; This family includes mostly bacterial proteins homologous to Rhizobium leguminosarum YP_766765.1, a protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380433 [Multi-domain]  Cd Length: 90  Bit Score: 36.88  E-value: 7.83e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 15595732 136 YVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYANRSQAPVRVLWVYA 184
Cdd:cd20299  42 VVLEGELTVTTDGEEVVLGPGDSCYIPPGETRSIDNRTNGPATMLVTTP 90
cupin_QDO_N_C cd02215
quercetinase, N- and C-terminal cupin domains; This family contains quercetinase (also known ...
 85-164 8.47e-04

quercetinase, N- and C-terminal cupin domains; This family contains quercetinase (also known as quercetin 2,3-dioxygenase, 2,3QD, QDO and YxaG; EC 1.13.11.24), a mononuclear copper-dependent dioxygenase that catalyzes the cleavage of the flavonol quercetin (5,7,3',4'-tetrahydroxyflavonol) heterocyclic ring to produce 2-protocatechuoyl-phloroglucinol carboxylic acid and carbon monoxide. Bacillus subtilis quercetin 2,3-dioxygenase (QDO) is a homodimer that shows oxygenase activity with several divalent metals such as Mn2+, Co2+, Fe2+, and Cu2+, although the preferred one appears to be Mn2+. The dioxygen binds to the metal ion of the Cu-QDO-quercetin complex, yielding a Cu2+-superoxo quercetin radical intermediate, which then forms a Cu2+-alkylperoxo complex which then evolves into endoperoxide intermediate that decomposes to the product. Quercetinase is a bicupin with two tandem cupin beta-barrel domains, both of which are included in this alignment model. The pirins, which also belong to the cupin domain family, have been shown to catalyze a reaction involving quercetin and may have a function similar to that of quercetinase.


Pssm-ID: 380345 [Multi-domain]  Cd Length: 122  Bit Score: 37.52  E-value: 8.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595732  85 GERRTLA------YARGASDnlvsprlGGAFFMLETclEAGADSG--------ERDLLdsseqggYVLEGELTLWLEDEE 150
Cdd:cd02215   9 GERYLVGgqlftvLATGEST-------GGAFTLVTT--EGPKGDAipphyhkrHHETF-------YVLEGRLQLWLDGES 72

                        90       100
                ....*....|....*....|....
gi 15595732 151 LRLQAGD----------GFQIPSH 164
Cdd:cd02215  73 RLLTPGDfasvppgtihAYRMLSP 96
cupin_YdbB-like cd02226
Bacillus subtilis YdbB and related proteins, cupin domain; This family includes bacterial ...
 136-162 8.94e-04

Bacillus subtilis YdbB and related proteins, cupin domain; This family includes bacterial proteins homologous to YdbB, a Bacillus subtilis protein of unknown function. It also includes protein Nmb1881 From Neisseria meningitidis, also of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380355 [Multi-domain]  Cd Length: 94  Bit Score: 37.04  E-value: 8.94e-04
                        10        20
                ....*....|....*....|....*..
gi 15595732 136 YVLEGELTLWLEDEELRLQAGDGFQIP 162
Cdd:cd02226  48 LVLEGELTIDFRDRDVTLGPGEFFVVP 74
cupin_MmsR-like_N cd06986
AraC/XylS family transcriptional regulators similar to MmsR, N-terminal cupin domain; This ...
 136-169 1.43e-03

AraC/XylS family transcriptional regulators similar to MmsR, N-terminal cupin domain; This family contains bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included is MmsR, a bacterial transcriptional regulator thought to positively regulate the expression of the mmsAB operon. The mmsAB operon contains two structural genes involved in valine metabolism: mmsA which encodes methylmalonate-semialdehyde dehydrogenase, and mmsB which encodes 3-hydroxyisobutyrate dehydrogenase. The cupin domain of members of this subfamily does not contain a metal binding site.


Pssm-ID: 380391 [Multi-domain]  Cd Length: 84  Bit Score: 36.31  E-value: 1.43e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 15595732 136 YVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRY 169
Cdd:cd06986  33 YVLSGKGTFSVNGKTYHLKAGQGFLIPPGEPHSY 66
cupin_dsy2733 cd06983
Desulfitobacterium hafniense dsy2733 and related proteins, cupin domain; This family includes ...
 136-164 1.53e-03

Desulfitobacterium hafniense dsy2733 and related proteins, cupin domain; This family includes bacterial proteins homologous to dsy2733, a Desulfitobacterium hafniense protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380388 [Multi-domain]  Cd Length: 81  Bit Score: 36.07  E-value: 1.53e-03
                        10        20
                ....*....|....*....|....*....
gi 15595732 136 YVLEGELTLWLEDEELRLQAGDGFQIPSH 164
Cdd:cd06983  35 YVLEGEAEITIGDEKHRLKAGDVLAVPAG 63
cupin_reut_a1446 cd06981
Cupriavidus pinatubonensis reut_a1446 and related proteins, cupin domain; This family includes ...
 137-168 2.33e-03

Cupriavidus pinatubonensis reut_a1446 and related proteins, cupin domain; This family includes bacterial and some eukaryotic proteins homologous to reut_a1446, a Cupriavidus pinatubonensis protein of unknown function that may be related to mannose-6-phosphate isomerase. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380386  Cd Length: 103  Bit Score: 35.93  E-value: 2.33e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 15595732 137 VLEGELTLWLED-EELRLQAGDGFQIPSHMRSR 168
Cdd:cd06981  54 LLQGEAELEFEDgEEVELKPGDYLLIPAHCRHR 86
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 6-46 2.82e-03

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 35.17  E-value: 2.82e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15595732   6 DDLAEIASLVRELRKRKGITLQALADGIRRSVGFVSQVERG 46
Cdd:COG1426   1 EALETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEG 41
cupin_RemF-like cd06979
Streptomyces resistomycificus RemF cyclase and related proteins, cupin domain; RemF cyclase is ...
 106-184 2.85e-03

Streptomyces resistomycificus RemF cyclase and related proteins, cupin domain; RemF cyclase is a manganese-containing polyketide cyclase present in bacteria that is involved in the biosynthesis of resistomycin, the aromatic pentacyclic metabolite in Streptomyces resistomycificus. Structure of this enzyme shows a cupin fold with a conserved "jelly roll-like" beta-barrel fold that forms a homodimer. It contains an unusual octahedral zinc-binding site in a large hydrophobic pocket that may represent the active site. The zinc ion, coordinated to four histidine side chains and two water molecules, could act as a Lewis acid in the aldol condensation reaction catalyzed by RemF, reminiscent of class II aldolases.


Pssm-ID: 380384 [Multi-domain]  Cd Length: 93  Bit Score: 35.52  E-value: 2.85e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15595732 106 GGAFFMLETCLEAGADSGERDLLDSSEQGGYVLEGELTLWLEDEELRLQAGDGFQIPSHMRSRYANRSQAPVRVLWVYA 184
Cdd:cd06979  14 ADRFDLFEFEVSPNAGMPPPHYHEDWEETIYGLEGSVTLTLPGKTVEVGPGDSIFIPRGEVHGFVNRSGGPTCRLCVLA 92
cupin_bxe_c0505 cd06980
uncharacterized protein bxe_c0505, cupin domain; This family includes mostly bacterial ...
 136-168 5.29e-03

uncharacterized protein bxe_c0505, cupin domain; This family includes mostly bacterial proteins homologous to bxe_c0505, a Burkholderia xenovorans protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380385 [Multi-domain]  Cd Length: 105  Bit Score: 34.85  E-value: 5.29e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 15595732 136 YVLEGELTLWLED-EELRLQAGDGFQIPSHMRSR 168
Cdd:cd06980  49 YVLKGWVKFEFEGgGEVRLEAGDCVYQPPGIRHN 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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