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Conserved domains on  [gi|15595749|ref|NP_249243|]
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phosphoglycerate kinase [Pseudomonas aeruginosa PAO1]

Protein Classification

phosphoglycerate kinase( domain architecture ID 10011204)

phosphoglycerate kinase catalyzes the conversion of ATP and 3-phospho-D-glycerate to ADP and 3-phospho-D-glyceroyl phosphate

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
pgk PRK00073
phosphoglycerate kinase; Provisional
3-383 0e+00

phosphoglycerate kinase; Provisional


:

Pssm-ID: 234613  Cd Length: 389  Bit Score: 630.55  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749    3 VLKMTDLDLKGKRVLIREDLNVPVKDGQVQSDARIKAALPTLKLALEKGAAVMVCSHLGRPTeGEFsAENSLKPVAEYLS 82
Cdd:PRK00073   1 KKTLDDLDLKGKRVLVRVDFNVPVKDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRPK-GED-PEFSLAPVAKRLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   83 KALGREVPLLADYLDG------VEVKAGDLVLFENVRFNKGEKKNADELAQKYAALCDVFVMDAFGTAHRAEGSTHGVAR 156
Cdd:PRK00073  79 ELLGKEVKFVDDCIGEeareaiAALKDGEVLLLENVRFNKGEEKNDPELAKKLASLGDVFVNDAFGTAHRAHASTVGIAK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  157 FAKVAAAGPLLAAELDALGKALGNPARPMAAIVAGSKVSTKLDVLNSLAGICDQLIVGGGIANTFLAAAGHKVGKSLYEA 236
Cdd:PRK00073 159 FLKPAAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVLENLLEKVDKLIIGGGMANTFLKAQGYNVGKSLVEE 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  237 DLVETAKAIAAK-----VKVPLPVDVVVAKEFAEsAVATVKAIAEVADDDMILDIGPQTAAQFAELLKTSKTILWNGPVG 311
Cdd:PRK00073 239 DLIDTAKELLEKakekgVKIPLPVDVVVAKEFSD-AEATVVSVDEIPDDWMILDIGPKTIELFAEIIKDAKTIVWNGPMG 317
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15595749  312 VFEFDQFGEGTRTLANAIADSAAFSIAGGGDTLAAIDKYGIAERISYISTGGGAFLEFVEGKVLPAVEILEQ 383
Cdd:PRK00073 318 VFEFENFAKGTKAVAKAIAESTAFSIIGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGKELPGVAALEE 389
 
Name Accession Description Interval E-value
pgk PRK00073
phosphoglycerate kinase; Provisional
3-383 0e+00

phosphoglycerate kinase; Provisional


Pssm-ID: 234613  Cd Length: 389  Bit Score: 630.55  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749    3 VLKMTDLDLKGKRVLIREDLNVPVKDGQVQSDARIKAALPTLKLALEKGAAVMVCSHLGRPTeGEFsAENSLKPVAEYLS 82
Cdd:PRK00073   1 KKTLDDLDLKGKRVLVRVDFNVPVKDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRPK-GED-PEFSLAPVAKRLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   83 KALGREVPLLADYLDG------VEVKAGDLVLFENVRFNKGEKKNADELAQKYAALCDVFVMDAFGTAHRAEGSTHGVAR 156
Cdd:PRK00073  79 ELLGKEVKFVDDCIGEeareaiAALKDGEVLLLENVRFNKGEEKNDPELAKKLASLGDVFVNDAFGTAHRAHASTVGIAK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  157 FAKVAAAGPLLAAELDALGKALGNPARPMAAIVAGSKVSTKLDVLNSLAGICDQLIVGGGIANTFLAAAGHKVGKSLYEA 236
Cdd:PRK00073 159 FLKPAAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVLENLLEKVDKLIIGGGMANTFLKAQGYNVGKSLVEE 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  237 DLVETAKAIAAK-----VKVPLPVDVVVAKEFAEsAVATVKAIAEVADDDMILDIGPQTAAQFAELLKTSKTILWNGPVG 311
Cdd:PRK00073 239 DLIDTAKELLEKakekgVKIPLPVDVVVAKEFSD-AEATVVSVDEIPDDWMILDIGPKTIELFAEIIKDAKTIVWNGPMG 317
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15595749  312 VFEFDQFGEGTRTLANAIADSAAFSIAGGGDTLAAIDKYGIAERISYISTGGGAFLEFVEGKVLPAVEILEQ 383
Cdd:PRK00073 318 VFEFENFAKGTKAVAKAIAESTAFSIIGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGKELPGVAALEE 389
PGK pfam00162
Phosphoglycerate kinase;
13-373 0e+00

Phosphoglycerate kinase;


Pssm-ID: 425495  Cd Length: 370  Bit Score: 541.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749    13 GKRVLIREDLNVPVKD-GQVQSDARIKAALPTLKLALEKGAAVMVCSHLGRPtEGEFsAENSLKPVAEYLSKALGREVPL 91
Cdd:pfam00162   1 GKRVLVRVDFNVPLDDdGKITDDTRIRAALPTIKYLLEKGAKVILMSHLGRP-KGKD-DKFSLKPVAERLSELLGKPVKF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749    92 LADYLDGVEVKA------GDLVLFENVRFNKGEKKNADELAQKYAALCDVFVMDAFGTAHRAEGSTHGVARFAKvAAAGP 165
Cdd:pfam00162  79 ADDCIGPEAEAAiaalkpGEVLLLENVRFYKEEEKNDPEFAKKLASLADVYVNDAFGTAHRAHASTVGVAKFLP-SAAGF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   166 LLAAELDALGKALGNPARPMAAIVAGSKVSTKLDVLNSLAGICDQLIVGGGIANTFLAAAGHKVGKSLYEADLVETAKAI 245
Cdd:pfam00162 158 LMEKELEALSKALENPERPFVAILGGAKVSDKIGVIENLLDKVDKLIIGGGMANTFLKAQGYEIGKSLVEEDKIELAKEL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   246 AAK-----VKVPLPVDVVVAKEFaeSAVATVKAIAEVADDDMILDIGPQTAAQFAELLKTSKTILWNGPVGVFEFDQFGE 320
Cdd:pfam00162 238 LEKakakgVKIVLPVDVVVADEF--SAEGKVVDVDEIPDDWMGLDIGPETIELFAEVIKKAKTIVWNGPMGVFEFENFAK 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15595749   321 GTRTLANAIADSA--AFSIAGGGDTLAAIDKYGIAERISYISTGGGAFLEFVEGK 373
Cdd:pfam00162 316 GTKAVAKAIAEATagAFSIVGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGK 370
Pgk COG0126
3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase ...
6-384 0e+00

3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439896  Cd Length: 389  Bit Score: 541.54  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   6 MTDLDLKGKRVLIREDLNVPVKDGQVQSDARIKAALPTLKLALEKGAAVMVCSHLGRPtEGEFSAENSLKPVAEYLSKAL 85
Cdd:COG0126   2 LDDLDLKGKRVLVRVDFNVPLDDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRP-KGKVDPKYSLKPVAERLSELL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  86 GREVPLLADyLDGVEVKA-------GDLVLFENVRFNKGEKKNADELAQKYAALCDVFVMDAFGTAHRAEGSTHGVARFA 158
Cdd:COG0126  81 GKPVKFVDD-CIGEEAEAavaalkpGEVLLLENLRFHPEEEKNDPEFAKKLASLGDVYVNDAFGTAHRAHASTVGIAKLL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749 159 KvAAAGPLLAAELDALGKALGNPARPMAAIVAGSKVSTKLDVLNSLAGICDQLIVGGGIANTFLAAAGHKVGKSLYEADL 238
Cdd:COG0126 160 P-SAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVIENLLEKVDKLLIGGGMANTFLKAQGYDVGKSLVEEDK 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749 239 VETAKAIAAK-----VKVPLPVDVVVAKEFAESAVATVKAIAEVADDDMILDIGPQTAAQFAELLKTSKTILWNGPVGVF 313
Cdd:COG0126 239 IDTAKEILEKakekgVKIVLPVDVVVADEFSADAERKVVPVDEIPDDWMGLDIGPKTIELFAEVIKDAKTVVWNGPMGVF 318
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15595749 314 EFDQFGEGTRTLANAIADSAAFSIAGGGDTLAAIDKYGIAERISYISTGGGAFLEFVEGKVLPAVEILEQR 384
Cdd:COG0126 319 EMEPFAKGTRAVAKAIAESGAFSVVGGGDTAAAVNKLGLADKFSHVSTGGGASLEFLEGKELPGVEALEDK 389
Phosphoglycerate_kinase cd00318
Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the ...
6-383 1.81e-174

Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level phosphorylation events in the glycolytic pathway. Substrate-level phosphorylation is defined as production of ATP by a process, which is catalyzed by water-soluble enzymes in the cytosol; not involving membranes and ion gradients.


Pssm-ID: 238195  Cd Length: 397  Bit Score: 491.77  E-value: 1.81e-174
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   6 MTDLDLKGKRVLIREDLNVPVKDGQVQSDARIKAALPTLKLALEKGAAVMVCSHLGRPTeGEFSAENSLKPVAEYLSKAL 85
Cdd:cd00318   1 IDDLDLKGKRVLVRVDFNVPVDDGKITDDTRIRAALPTIKYLLEQGAKVVLLSHLGRPK-GEPNEKYSLAPVAKALSELL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  86 GREVPLLADYLdGVEVKA-------GDLVLFENVRFNKGEKKNAD-------ELAQKYAALCDVFVMDAFGTAHRAEGST 151
Cdd:cd00318  80 GQPVTFANDCV-GPEAEEavealkpGDVLLLENVRFYPEEEGKRDddkeadeEFAKKLASLGDVYVNDAFGTAHRAHASM 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749 152 HGVARFaKVAAAGPLLAAELDALGKALGNPARPMAAIVAGSKVSTKLDVLNSLAGICDQLIVGGGIANTFLAAAGHKVGK 231
Cdd:cd00318 159 VGIALL-LPSAAGFLMEKELKYLAKALENPERPFVAILGGAKVSDKIQVIENLLDKVDYLIIGGGMAFTFLKAQGMDIGK 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749 232 SLYEADLVETAKAIAAK-----VKVPLPVDVVVAKEFAESAVATVKAIAEVADDDMILDIGPQTAAQFAELLKTSKTILW 306
Cdd:cd00318 238 SLFEEDGIELAKSLLEKakakgVKIVLPVDVVVADKFKADANTKVVTDDGIPDGWMGLDIGPKTIELFAEVIRKAKTIVW 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749 307 NGPVGVFEFDQFGEGTRTLANAIADSA---AFSIAGGGDTLAAIDKYGIAERISYISTGGGAFLEFVEGKVLPAVEILEQ 383
Cdd:cd00318 318 NGPMGVFEFPAFAKGTKAIADAIAAATkagAFSIIGGGDTAAAAEKFGLADKISHVSTGGGASLELLEGKELPGVAALEE 397
 
Name Accession Description Interval E-value
pgk PRK00073
phosphoglycerate kinase; Provisional
3-383 0e+00

phosphoglycerate kinase; Provisional


Pssm-ID: 234613  Cd Length: 389  Bit Score: 630.55  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749    3 VLKMTDLDLKGKRVLIREDLNVPVKDGQVQSDARIKAALPTLKLALEKGAAVMVCSHLGRPTeGEFsAENSLKPVAEYLS 82
Cdd:PRK00073   1 KKTLDDLDLKGKRVLVRVDFNVPVKDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRPK-GED-PEFSLAPVAKRLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   83 KALGREVPLLADYLDG------VEVKAGDLVLFENVRFNKGEKKNADELAQKYAALCDVFVMDAFGTAHRAEGSTHGVAR 156
Cdd:PRK00073  79 ELLGKEVKFVDDCIGEeareaiAALKDGEVLLLENVRFNKGEEKNDPELAKKLASLGDVFVNDAFGTAHRAHASTVGIAK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  157 FAKVAAAGPLLAAELDALGKALGNPARPMAAIVAGSKVSTKLDVLNSLAGICDQLIVGGGIANTFLAAAGHKVGKSLYEA 236
Cdd:PRK00073 159 FLKPAAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVLENLLEKVDKLIIGGGMANTFLKAQGYNVGKSLVEE 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  237 DLVETAKAIAAK-----VKVPLPVDVVVAKEFAEsAVATVKAIAEVADDDMILDIGPQTAAQFAELLKTSKTILWNGPVG 311
Cdd:PRK00073 239 DLIDTAKELLEKakekgVKIPLPVDVVVAKEFSD-AEATVVSVDEIPDDWMILDIGPKTIELFAEIIKDAKTIVWNGPMG 317
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15595749  312 VFEFDQFGEGTRTLANAIADSAAFSIAGGGDTLAAIDKYGIAERISYISTGGGAFLEFVEGKVLPAVEILEQ 383
Cdd:PRK00073 318 VFEFENFAKGTKAVAKAIAESTAFSIIGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGKELPGVAALEE 389
PGK pfam00162
Phosphoglycerate kinase;
13-373 0e+00

Phosphoglycerate kinase;


Pssm-ID: 425495  Cd Length: 370  Bit Score: 541.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749    13 GKRVLIREDLNVPVKD-GQVQSDARIKAALPTLKLALEKGAAVMVCSHLGRPtEGEFsAENSLKPVAEYLSKALGREVPL 91
Cdd:pfam00162   1 GKRVLVRVDFNVPLDDdGKITDDTRIRAALPTIKYLLEKGAKVILMSHLGRP-KGKD-DKFSLKPVAERLSELLGKPVKF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749    92 LADYLDGVEVKA------GDLVLFENVRFNKGEKKNADELAQKYAALCDVFVMDAFGTAHRAEGSTHGVARFAKvAAAGP 165
Cdd:pfam00162  79 ADDCIGPEAEAAiaalkpGEVLLLENVRFYKEEEKNDPEFAKKLASLADVYVNDAFGTAHRAHASTVGVAKFLP-SAAGF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   166 LLAAELDALGKALGNPARPMAAIVAGSKVSTKLDVLNSLAGICDQLIVGGGIANTFLAAAGHKVGKSLYEADLVETAKAI 245
Cdd:pfam00162 158 LMEKELEALSKALENPERPFVAILGGAKVSDKIGVIENLLDKVDKLIIGGGMANTFLKAQGYEIGKSLVEEDKIELAKEL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   246 AAK-----VKVPLPVDVVVAKEFaeSAVATVKAIAEVADDDMILDIGPQTAAQFAELLKTSKTILWNGPVGVFEFDQFGE 320
Cdd:pfam00162 238 LEKakakgVKIVLPVDVVVADEF--SAEGKVVDVDEIPDDWMGLDIGPETIELFAEVIKKAKTIVWNGPMGVFEFENFAK 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15595749   321 GTRTLANAIADSA--AFSIAGGGDTLAAIDKYGIAERISYISTGGGAFLEFVEGK 373
Cdd:pfam00162 316 GTKAVAKAIAEATagAFSIVGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGK 370
Pgk COG0126
3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase ...
6-384 0e+00

3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439896  Cd Length: 389  Bit Score: 541.54  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   6 MTDLDLKGKRVLIREDLNVPVKDGQVQSDARIKAALPTLKLALEKGAAVMVCSHLGRPtEGEFSAENSLKPVAEYLSKAL 85
Cdd:COG0126   2 LDDLDLKGKRVLVRVDFNVPLDDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRP-KGKVDPKYSLKPVAERLSELL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  86 GREVPLLADyLDGVEVKA-------GDLVLFENVRFNKGEKKNADELAQKYAALCDVFVMDAFGTAHRAEGSTHGVARFA 158
Cdd:COG0126  81 GKPVKFVDD-CIGEEAEAavaalkpGEVLLLENLRFHPEEEKNDPEFAKKLASLGDVYVNDAFGTAHRAHASTVGIAKLL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749 159 KvAAAGPLLAAELDALGKALGNPARPMAAIVAGSKVSTKLDVLNSLAGICDQLIVGGGIANTFLAAAGHKVGKSLYEADL 238
Cdd:COG0126 160 P-SAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVIENLLEKVDKLLIGGGMANTFLKAQGYDVGKSLVEEDK 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749 239 VETAKAIAAK-----VKVPLPVDVVVAKEFAESAVATVKAIAEVADDDMILDIGPQTAAQFAELLKTSKTILWNGPVGVF 313
Cdd:COG0126 239 IDTAKEILEKakekgVKIVLPVDVVVADEFSADAERKVVPVDEIPDDWMGLDIGPKTIELFAEVIKDAKTVVWNGPMGVF 318
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15595749 314 EFDQFGEGTRTLANAIADSAAFSIAGGGDTLAAIDKYGIAERISYISTGGGAFLEFVEGKVLPAVEILEQR 384
Cdd:COG0126 319 EMEPFAKGTRAVAKAIAESGAFSVVGGGDTAAAVNKLGLADKFSHVSTGGGASLEFLEGKELPGVEALEDK 389
Phosphoglycerate_kinase cd00318
Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the ...
6-383 1.81e-174

Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level phosphorylation events in the glycolytic pathway. Substrate-level phosphorylation is defined as production of ATP by a process, which is catalyzed by water-soluble enzymes in the cytosol; not involving membranes and ion gradients.


Pssm-ID: 238195  Cd Length: 397  Bit Score: 491.77  E-value: 1.81e-174
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   6 MTDLDLKGKRVLIREDLNVPVKDGQVQSDARIKAALPTLKLALEKGAAVMVCSHLGRPTeGEFSAENSLKPVAEYLSKAL 85
Cdd:cd00318   1 IDDLDLKGKRVLVRVDFNVPVDDGKITDDTRIRAALPTIKYLLEQGAKVVLLSHLGRPK-GEPNEKYSLAPVAKALSELL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  86 GREVPLLADYLdGVEVKA-------GDLVLFENVRFNKGEKKNAD-------ELAQKYAALCDVFVMDAFGTAHRAEGST 151
Cdd:cd00318  80 GQPVTFANDCV-GPEAEEavealkpGDVLLLENVRFYPEEEGKRDddkeadeEFAKKLASLGDVYVNDAFGTAHRAHASM 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749 152 HGVARFaKVAAAGPLLAAELDALGKALGNPARPMAAIVAGSKVSTKLDVLNSLAGICDQLIVGGGIANTFLAAAGHKVGK 231
Cdd:cd00318 159 VGIALL-LPSAAGFLMEKELKYLAKALENPERPFVAILGGAKVSDKIQVIENLLDKVDYLIIGGGMAFTFLKAQGMDIGK 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749 232 SLYEADLVETAKAIAAK-----VKVPLPVDVVVAKEFAESAVATVKAIAEVADDDMILDIGPQTAAQFAELLKTSKTILW 306
Cdd:cd00318 238 SLFEEDGIELAKSLLEKakakgVKIVLPVDVVVADKFKADANTKVVTDDGIPDGWMGLDIGPKTIELFAEVIRKAKTIVW 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749 307 NGPVGVFEFDQFGEGTRTLANAIADSA---AFSIAGGGDTLAAIDKYGIAERISYISTGGGAFLEFVEGKVLPAVEILEQ 383
Cdd:cd00318 318 NGPMGVFEFPAFAKGTKAIADAIAAATkagAFSIIGGGDTAAAAEKFGLADKISHVSTGGGASLELLEGKELPGVAALEE 397
PRK13962 PRK13962
bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional
1-381 7.43e-145

bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional


Pssm-ID: 237572 [Multi-domain]  Cd Length: 645  Bit Score: 425.29  E-value: 7.43e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749    1 MTVLKMTDLDLKGKRVLIREDLNVPVK-DGQVQSDARIKAALPTLKLALEKGAAVMVCSHLGRPtEGEFSAENSLKPVAE 79
Cdd:PRK13962   1 MNKKTIRDIDVKGKRVIVRVDFNVPLDeNGNITDDTRIRAALPTIKYLLDHGAKVILVSHLGRP-KGEFDPKFSMAPVAK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   80 YLSKALGREVpLLADYLDGVEVKA-------GDLVLFENVRFNKGEKKNADELAQKYAALCDVFVMDAFGTAHRAEGSTH 152
Cdd:PRK13962  80 RLSELLGKEV-IFAKDVIGDDAKKavaqlkeGDVLLLENVRFHKEETKNDPEFAKELASLADIYVNDAFGTAHRAHASTA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  153 GVARFAKvAAAGPLLAAELDALGKALGNPARPMAAIVAGSKVSTKLDVLNSLAGICDQLIVGGGIANTFLAAAGHKVGKS 232
Cdd:PRK13962 159 GVAEYLP-AVAGFLMEKEIEFLGKALANPQRPFVAILGGAKVSDKIGVIENLLEKVDKLLIGGGMAYTFLKAKGYEVGKS 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  233 LYEADLVETAKAIAAK-----VKVPLPVDVVVAKEFAESAVATVKAIAEVADDDMILDIGPQTAAQFAELLKTSKTILWN 307
Cdd:PRK13962 238 LVEEDKLDLAKELLAKaeekgVKLLLPVDSVVAKEFKNDAEHKVVPSDAIPEDWMGLDIGPETIELFAKKIADAKTIVWN 317
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15595749  308 GPVGVFEFDQFGEGTRTLANAIADSAAFSIAGGGDTLAAIDKYGIAERISYISTGGGAFLEFVEGKVLPAVEIL 381
Cdd:PRK13962 318 GPMGVFEFDNFAEGTRAVAEAVAESGAITIIGGGDSAAAVEKLGFADKMSHISTGGGASLEFLEGKVLPGIACL 391
PLN02282 PLN02282
phosphoglycerate kinase
2-383 7.03e-118

phosphoglycerate kinase


Pssm-ID: 165923  Cd Length: 401  Bit Score: 348.11  E-value: 7.03e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749    2 TVLKMTDLDLKGKRVLIREDLNVPVKDGQ-VQSDARIKAALPTLKLALEKGAAVMVCSHLGRPTEgeFSAENSLKPVAEY 80
Cdd:PLN02282   6 SVGTLKEADLKGKRVFVRVDLNVPLDDNSnITDDTRIRAAVPTIKYLMGHGARVILCSHLGRPKG--VTPKYSLKPLVPR 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   81 LSKALGREVPLLADYLdGVEVKA-------GDLVLFENVRFNKGEKKNADELAQKYAALCDVFVMDAFGTAHRAEGSTHG 153
Cdd:PLN02282  84 LSELLGVEVVMANDCI-GEEVEKlvaelpeGGVLLLENVRFYKEEEKNDPEFAKKLASLADVYVNDAFGTAHRAHASTEG 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  154 VARFAKVAAAGPLLAAELDALGKALGNPARPMAAIVAGSKVSTKLDVLNSLAGICDQLIVGGGIANTFLAAAGHKVGKSL 233
Cdd:PLN02282 163 VAKYLKPSVAGFLMQKELDYLVGAVANPKKPFAAIVGGSKVSTKIGVIESLLEKVDILLLGGGMIFTFYKAQGYSVGSSL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  234 YEADLVETAKAIAAKVKVP-----LPVDVVVAKEFAESAVATVKAIAEVADDDMILDIGPQTAAQFAELLKTSKTILWNG 308
Cdd:PLN02282 243 VEEDKLDLATSLIEKAKAKgvsllLPTDVVIADKFAPDANSKVVPASAIPDGWMGLDIGPDSIKTFSEALDTTKTIIWNG 322
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15595749  309 PVGVFEFDQFGEGTRTLANAIAD---SAAFSIAGGGDTLAAIDKYGIAERISYISTGGGAFLEFVEGKVLPAVEILEQ 383
Cdd:PLN02282 323 PMGVFEFEKFAAGTEAIAKKLAElsgKGVTTIIGGGDSVAAVEKVGLADKMSHISTGGGASLELLEGKPLPGVLALDD 400
PLN03034 PLN03034
phosphoglycerate kinase; Provisional
2-383 1.53e-113

phosphoglycerate kinase; Provisional


Pssm-ID: 178602 [Multi-domain]  Cd Length: 481  Bit Score: 339.67  E-value: 1.53e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749    2 TVLKMTDLDLKGKRVLIREDLNVPVKDGQ-VQSDARIKAALPTLKLALEKGAAVMVCSHLGRPTEgeFSAENSLKPVAEY 80
Cdd:PLN03034  81 SVGDLTSADLKGKKVFVRADLNVPLDDNQnITDDTRIRAAIPTIKYLISNGAKVILSSHLGRPKG--VTPKFSLAPLVPR 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   81 LSKALGREVpLLADYLDGVEVKA-------GDLVLFENVRFNKGEKKNADELAQKYAALCDVFVMDAFGTAHRAEGSTHG 153
Cdd:PLN03034 159 LSELLGIQV-VKADDCIGPEVEKlvaslpeGGVLLLENVRFYKEEEKNEPEFAKKLASLADLYVNDAFGTAHRAHASTEG 237
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  154 VARFAKVAAAGPLLAAELDALGKALGNPARPMAAIVAGSKVSTKLDVLNSLAGICDQLIVGGGIANTFLAAAGHKVGKSL 233
Cdd:PLN03034 238 VTKFLKPSVAGFLLQKELDYLVGAVSNPKRPFAAIVGGSKVSSKIGVIESLLEKCDILLLGGGMIFTFYKAQGLSVGSSL 317
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  234 YEADLVETAKAIAAKVKVP-----LPVDVVVAKEFAESAVATVKAIAEVADDDMILDIGPQTAAQFAELLKTSKTILWNG 308
Cdd:PLN03034 318 VEEDKLELATSLLAKAKAKgvsllLPTDVVIADKFAPDANSKIVPASAIPDGWMGLDIGPDSVKTFNEALDTTQTVIWNG 397
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15595749  309 PVGVFEFDQFGEGTRTLANAIADSAA---FSIAGGGDTLAAIDKYGIAERISYISTGGGAFLEFVEGKVLPAVEILEQ 383
Cdd:PLN03034 398 PMGVFEFEKFAVGTEAVAKKLAELSGkgvTTIIGGGDSVAAVEKVGVADVMSHISTGGGASLELLEGKELPGVVALDE 475
PTZ00005 PTZ00005
phosphoglycerate kinase; Provisional
4-384 3.47e-108

phosphoglycerate kinase; Provisional


Pssm-ID: 173310  Cd Length: 417  Bit Score: 323.94  E-value: 3.47e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749    4 LKMTDLD--LKGKRVLIREDLNVPVKDGQVQSDARIKAALPTLKLALEKGAA-VMVCSHLGRPtEGEFSAENSLKPVAEY 80
Cdd:PTZ00005   6 LGIDDVDdqLKGKRVLIRVDFNVPIKEGVIKDATRIKATLPTIKYLLEQGAKsVVLMSHLGRP-DGRRVEKYSLKPVVPK 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749   81 LSKALGREVPLLADYLdGVEV-------KAGDLVLFENVRFNKGEK-----------KNADELAQKY----AALCDVFVM 138
Cdd:PTZ00005  85 LEELLGKKVTFLNDCV-GPEVeeacanaKNGSVILLENLRFHIEEEgkgvdangnkvKADKEEVKKFrkslTKLGDIYVN 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  139 DAFGTAHRAEGSTHGVArfAKVAAAGPLLAAELDALGKALGNPARPMAAIVAGSKVSTKLDVLNSLAGICDQLIVGGGIA 218
Cdd:PTZ00005 164 DAFGTAHRAHSSMVGVD--LPVKVAGFLMKKELDYFSKALENPQRPFLAILGGAKVADKIQLIKNLLDKVDEMIIGGGMA 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  219 NTFLAA-AGHKVGKSLYE---ADLVET--AKAIAAKVKVPLPVDVVVAKEF-AESAVATVKAIAEVADDDMILDIGPQTA 291
Cdd:PTZ00005 242 FTFKKVlDNMPIGKSLFDeegAKIVKEimEKAKEKNVKIHLPVDFVCADKFdNNANTKVVTDKEGIPDGWMGLDAGPKSI 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595749  292 AQFAELLKTSKTILWNGPVGVFEFDQFGEGTRTLANAIA---DSAAFSIAGGGDTLAAIDKYGIAERISYISTGGGAFLE 368
Cdd:PTZ00005 322 EEFAEAILRAKTIVWNGPQGVFEMPNFAKGSIAMLDAVVkatEKGAITIVGGGDTASLVEKTGAANKVSHVSTGGGASLE 401
                        410
                 ....*....|....*.
gi 15595749  369 FVEGKVLPAVEILEQR 384
Cdd:PTZ00005 402 LLEGKELPGVVALSNK 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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