bifunctional lysylphosphatidylglycerol flippase/synthetase MprF; The C-terminal region of MprF ...
33-873
0e+00
bifunctional lysylphosphatidylglycerol flippase/synthetase MprF; The C-terminal region of MprF tranfers lysine from a charged tRNA onto phosphatidylglycerol to make lysylphosphatidylglycerol (EC 2.3.2.3). The N-terminal region of MprF acts as a flippase. MprF helps confer resistance to antimicrobial cationic peptides.
:
Pssm-ID: 468043 [Multi-domain] Cd Length: 839 Bit Score: 742.79 E-value: 0e+00
bifunctional lysylphosphatidylglycerol flippase/synthetase MprF; The C-terminal region of MprF ...
33-873
0e+00
bifunctional lysylphosphatidylglycerol flippase/synthetase MprF; The C-terminal region of MprF tranfers lysine from a charged tRNA onto phosphatidylglycerol to make lysylphosphatidylglycerol (EC 2.3.2.3). The N-terminal region of MprF acts as a flippase. MprF helps confer resistance to antimicrobial cationic peptides.
Pssm-ID: 468043 [Multi-domain] Cd Length: 839 Bit Score: 742.79 E-value: 0e+00
Phosphatidylglycerol lysyltransferase, C-terminal; This domain can be found in the C-terminal ...
565-853
5.57e-103
Phosphatidylglycerol lysyltransferase, C-terminal; This domain can be found in the C-terminal region of phosphatidylglycerol lysyltransferase mprF, which catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG). This domain can also be found in lysylphosphatidylglycerol biosynthesis bifunctional protein LysX, which is the two-domain lysyl-transferase (mprF)-lysyl-tRNA synthetase (lysU) protein is responsible for LPG production.
Pssm-ID: 430930 [Multi-domain] Cd Length: 297 Bit Score: 321.14 E-value: 5.57e-103
bifunctional lysylphosphatidylglycerol flippase/synthetase MprF; The C-terminal region of MprF ...
33-873
0e+00
bifunctional lysylphosphatidylglycerol flippase/synthetase MprF; The C-terminal region of MprF tranfers lysine from a charged tRNA onto phosphatidylglycerol to make lysylphosphatidylglycerol (EC 2.3.2.3). The N-terminal region of MprF acts as a flippase. MprF helps confer resistance to antimicrobial cationic peptides.
Pssm-ID: 468043 [Multi-domain] Cd Length: 839 Bit Score: 742.79 E-value: 0e+00
Phosphatidylglycerol lysyltransferase, C-terminal; This domain can be found in the C-terminal ...
565-853
5.57e-103
Phosphatidylglycerol lysyltransferase, C-terminal; This domain can be found in the C-terminal region of phosphatidylglycerol lysyltransferase mprF, which catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG). This domain can also be found in lysylphosphatidylglycerol biosynthesis bifunctional protein LysX, which is the two-domain lysyl-transferase (mprF)-lysyl-tRNA synthetase (lysU) protein is responsible for LPG production.
Pssm-ID: 430930 [Multi-domain] Cd Length: 297 Bit Score: 321.14 E-value: 5.57e-103
Lysylphosphatidylglycerol synthase TM region; LPG_synthase_TM is the N-terminal region of this ...
36-303
8.74e-03
Lysylphosphatidylglycerol synthase TM region; LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defensins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.
Pssm-ID: 461018 Cd Length: 302 Bit Score: 39.27 E-value: 8.74e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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