|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
23-417 |
4.38e-146 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 421.71 E-value: 4.38e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 23 FVFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTAL 102
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 103 LGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIP----EFGWRTLF 178
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 179 FTAVAPALVCLALRPWVPESPSWLAAQAGRQrpgaapqshaeAGGAGPLGRMLGDPETRGMFLLWSLTSCFLLFGYYGTN 258
Cdd:cd17371 161 LLGALPALLVLFIRRFVKEPPQWQAARAARR-----------HFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGIT 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 259 NWMPSYLESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYH-SPSNILWILITF 337
Cdd:cd17371 230 TWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPlSPTLILILGFPL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 338 GFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGLIPALFIADR 417
Cdd:cd17371 310 GFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
12-387 |
2.55e-95 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 292.72 E-value: 2.55e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 12 PAISRRTMLIAFVFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTW 91
Cdd:TIGR00895 8 KQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 92 TIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPE 171
Cdd:TIGR00895 88 SILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 172 FGWRTLF-FTAVAPALVCLALRPWVPESPSWL---------------AAQAGRQRPGAAPQSHAEAGGAGPLGRMLGDPE 235
Cdd:TIGR00895 168 FGWRSLFyVGGIAPLLLLLLLMRFLPESIDFLvskrpetvrrivnaiAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGK 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 236 T-RGMFLLWSLTSCfLLFGYYGTNNWMPsYLESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTfAAGAIGS 314
Cdd:TIGR00895 248 TaRITVLLWLLYFM-LLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVT-ALLLLLG 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596216 315 AAFMPLIVF-YHSPSNILWILITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLA 387
Cdd:TIGR00895 325 AVFAVLVGStLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
23-409 |
1.08e-57 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 193.59 E-value: 1.08e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 23 FVFCFLGLLADGVDLMFLAYSLNSLKAEF--GLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGT 100
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 101 ALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIP----EFGWRT 176
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 177 LFFTAVAPALVCLALRPWVpespswlaaqagrqrpgaapqshaeaggagplgrmlgdpetrgmfLLWSLTSCFLLFGYYG 256
Cdd:cd17316 161 LFLIGALPALLALLLRRRT---------------------------------------------LLLILLWFFISFGYYG 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 257 TNNWMPSYLESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPL--IVFYHSPSNILWIL 334
Cdd:cd17316 196 LTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPlfYLLSGSPTLLLLLL 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15596216 335 ITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGLI 409
Cdd:cd17316 276 FILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-409 |
4.07e-51 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 176.60 E-value: 4.07e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 13 AISRRTMLIAFVFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWT 92
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 93 IVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEF 172
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 173 GWRTLFFTAVAPALVCLALRpwvpespswlaaqagrqrpgaapqshaeaggagplgrmlgdpetrgmFLLWSLTSCFLLF 252
Cdd:COG2271 162 GWRAAFLILGLPGLLLALLR-----------------------------------------------FWLLALAYFLVYF 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 253 GYYGTNNWMPSYLESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRR--LTFAAGAIGSAAFMPLIVFYHSPSNI 330
Cdd:COG2271 195 ALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALA 274
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596216 331 LWILITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGLI 409
Cdd:COG2271 275 IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALL 353
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
26-408 |
5.48e-41 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 149.27 E-value: 5.48e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 26 CFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGL 105
Cdd:cd17365 4 CFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 106 TQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPA 185
Cdd:cd17365 84 AQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 186 LVCLALrpwvpespswlaaqagrqrpgaapqshaeaggagplgrmlgdpeTRGMFLLWsLTSCFLLFGYYGTNNWMPSYL 265
Cdd:cd17365 164 LILLPL--------------------------------------------LRGTLLLW-VTFFMGLLLVYLLNSWLPKLM 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 266 EsELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFG--FIYGV 343
Cdd:cd17365 199 V-EAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAgaCVNGA 277
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596216 344 PVGVLAtYMTESFSTRVRGSAVGTAYNLGRIGAAVAPA-GIGLLATHVSIGAGFLVMGITYVLTGL 408
Cdd:cd17365 278 QVGLYA-LAARFYPTEVRATGVGWALGVGRLGAILGPLlGGLLLAAGLGPESVFLALAIPAALGAL 342
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-379 |
2.37e-39 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 144.73 E-value: 2.37e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 15 SRRTMLIAFVFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIV 94
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 95 LFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGW 174
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 175 RTLFFTAVAPALVCLAL-RPWVPESPswlaaqagrqrpgaapqSHAEAGGAGPLGRMLGDPETRGMFLLwsltSCFLLFG 253
Cdd:COG2814 164 RWVFLVNAVLALLALLLlLRLLPESR-----------------PAARARLRGSLRELLRRPRLLLLLLL----AFLLGFG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 254 YYGTNNWMPSYLESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWI 333
Cdd:COG2814 223 FFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLA 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 15596216 334 LITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVA 379
Cdd:COG2814 303 LFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
22-418 |
8.45e-36 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 136.98 E-value: 8.45e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 22 AFVFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTA 101
Cdd:PRK12307 19 ALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 102 LLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTA 181
Cdd:PRK12307 99 LSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 182 VAPALVCLALRPWVPESPSWLAAQAGRQRPGAAPQSHAEAGGAGPLGRMLGDPETRGMFLLwsltsCFLLFGY-YGTNNW 260
Cdd:PRK12307 179 LLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRAQFPLTLCVFIV-----LFSIFGAnWPIFGL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 261 MPSYLESElGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFI 340
Cdd:PRK12307 254 LPTYLAGE-GFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDNYLLLGACLFGLM 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 341 Y---GVpVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAG-FLVMGITYVLTGLIPALFIAD 416
Cdd:PRK12307 333 AtnvGV-GGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMGLGAAlTFIVAFWTATILLIIGLSIPD 411
|
..
gi 15596216 417 RL 418
Cdd:PRK12307 412 RL 413
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
15-405 |
1.68e-33 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 129.97 E-value: 1.68e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 15 SRRTMLIAFVFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIV 94
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 95 LFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSEcVGTRYRTTILAAMQAGWTVGYLVATLLAGQII---PE 171
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLIllgLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 172 FGWRTLFFTAVAPALVCLALrpwvpespswlaaQAGRQRPGAAPQSHAEAGGAGPLGRMLGDPetrgMFLLWSLTSCFLL 251
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALL-------------FLRSKLPEIEEEEEEAAGSAASLKSLLKNP----RLLLGGLAIFLYV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 252 FGYYGTNNWMPSYLESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNIL 331
Cdd:COG0738 224 GAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLAL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596216 332 WILITFGFIYGVPVGVLATYMTESFSTRvRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVL 405
Cdd:COG0738 304 IGLALVGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLL 376
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-415 |
2.30e-32 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 126.92 E-value: 2.30e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 13 AISRRTMLIAFVFCFLGLLadgvDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWT 92
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFG----VWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 93 IVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEF 172
Cdd:COG2223 77 LLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 173 GWRTLFFTAVAPALVCLAlrpwvpespswLAAQAGRQRPGAAPQshAEAGGAGPLGRMLGDPETRGMFLLWSLTScfllF 252
Cdd:COG2223 157 GWRNAFLILGILLLVVAV-----------LAWLFLRDPPAGAAA--AAKASLRDQLEALRDPRFWLLSLLYFGTF----G 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 253 GYYGTNNWMPSYLESELGMNfKSMTGYMVGTYSAM-ILGKVAAGVCADLFGR-RLTFAAGAIGSAAFMPLIVFYHSPSNI 330
Cdd:COG2223 220 SFIGFSSWLPPYLVDQFGLS-AATAGLLAALFALLgALGRPLGGWLSDRIGGrRVLLIVFALMALGLLLLALALGSLWLF 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 331 LWILITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHV-SIGAGFLVMGITYVLTGLI 409
Cdd:COG2223 299 LVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVL 378
|
....*.
gi 15596216 410 PALFIA 415
Cdd:COG2223 379 TLLLYR 384
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
25-409 |
2.99e-30 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 120.61 E-value: 2.99e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 25 FCFLGLLADGVDLMFLAYsLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLG 104
Cdd:cd06174 1 LLLGFFLTGLARGLISPL-LPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 105 LTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQII--PEFGWRTLFFTAV 182
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 183 APALVCLALRPWVPESPSWlaaqagrqRPGAAPQSHAEAGGAGPLGRMLGDPETRGMFLLWSLTScfllFGYYGTNNWMP 262
Cdd:cd06174 160 ALALLAAILLLLVVPDPPE--------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVN----LAYYSFSTLLP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 263 SYLESELGMNFKSMTGYMVGTYSAMILGKVAAGVCAD-LFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIY 341
Cdd:cd06174 228 LFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGL 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596216 342 GVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIG-LLATHVSIGAGFLVMGITYVLTGLI 409
Cdd:cd06174 308 GGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGfLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-401 |
8.35e-30 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 119.22 E-value: 8.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 26 CFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGL 105
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 106 TQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPA 185
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 186 LVCLALRPWVPEspswlaaqagRQRPGAAPQSHAEAGGAGPLGRMLGDPEtrgmFLLWSLTSCFLLFGYYGTNNWMPSYL 265
Cdd:cd17325 161 LLALVLALLLLP----------EPRPPPNKRAVSAARLRSGLRLLLRDRR----LLALFLAIFVLAFAFGALEPFLPLYA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 266 ESELGMNfKSMTGYMVGTYS-AMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVP 344
Cdd:cd17325 227 AELGGLS-PAQIGLLFGAQGlASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 15596216 345 VGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGI 401
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAA 362
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
37-409 |
5.66e-28 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 113.82 E-value: 5.66e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 37 LMFLAYSLN------------SLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLG 104
Cdd:cd17319 7 LLFLAYVINyldrvnisvaapTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 105 LTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAP 184
Cdd:cd17319 87 FATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 185 ALVCLALrpwvpespsWLAAqagrqrpgaapqshaeaggagpLGRMLgdpetrGMFLLWSLTSCfllfGYYGTNNWMPSY 264
Cdd:cd17319 167 GLLLAVL---------WWFY----------------------LRQVW------GLALGYFGINY----ALYGLLTWLPTY 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 265 LESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLF---GRRLTFAAGAIGSAAFMPLIVFYHSP-SNILWILITFGFI 340
Cdd:cd17319 206 LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPvVAVILLSLAGFGI 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 341 YGVpVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHV-SIGAGFLVMGITYVLTGLI 409
Cdd:cd17319 286 GAA-SPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATgSYTAAFLFLAAVALLAALL 354
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
25-380 |
6.08e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 113.67 E-value: 6.08e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 25 FCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLG 104
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 105 LTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAP 184
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 185 ALVCLALrpwvpespsWLAAQAGRQRPGAAPQSHAEAGGAGPLGRMLGDPetrgmFLLWSLTSCFLLFGYYGTNNWMPSY 264
Cdd:pfam07690 161 SLLAAVL---------LLLPRPPPESKRPKPAEEARLSLIVAWKALLRDP-----VLWLLLALLLFGFAFFGLLTYLPLY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 265 LEsELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRR---LTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIY 341
Cdd:pfam07690 227 QE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGF 305
|
330 340 350
....*....|....*....|....*....|....*....
gi 15596216 342 GVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAP 380
Cdd:pfam07690 306 GLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
22-409 |
1.50e-27 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 114.79 E-value: 1.50e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 22 AFVFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTA 101
Cdd:PRK03893 21 AFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 102 LLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTA 181
Cdd:PRK03893 101 ACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIG 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 182 VAPALVCLALRPWVPESPSWLAAQAGRQR-------------------------------------PGAAPQSHAEAGGA 224
Cdd:PRK03893 181 ILPIIFALWLRKNLPEAEDWKEKHAGKAPvrtmvdilyrgehriinilltlaaaaalwfcfagnlqNAAIVAVLGLLCAA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 225 GPLGRML---GDPETRGMFLLWSLTSCFLlfgyYG--TNNWMPSYLESELGMN--------FKSMTGYMVGTysamilgk 291
Cdd:PRK03893 261 IFISFMVqssGKRWPTGVMLMVVVLFAFL----YSwpIQALLPTYLKTDLGYDphtvanvlFFSGFGAAVGC-------- 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 292 VAAGVCADLFGRRLTFAAGAIGSAAFMpLIVFYHSPSNI--LWILITFGFIYGVPV-GVLATYMTESFSTRVRGSAVGTA 368
Cdd:PRK03893 329 CVGGFLGDWLGTRKAYVCSLLISQLLI-IPVFAIGGANVwvLGLLLFFQQMLGQGIsGLLPKLIGGYFDTEQRAAGLGFT 407
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 15596216 369 YNLGRIGAAVAPAGIGLLATHVSIGA--GFLVMGITYVLTGLI 409
Cdd:PRK03893 408 YNVGALGGALAPILGALIAQRLDLGTalASLSFSLTFVVILLI 450
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
15-415 |
5.77e-27 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 111.98 E-value: 5.77e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 15 SRRTMLIAFVFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIV 94
Cdd:PRK11551 9 SSSRLALTIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 95 LFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGW 174
Cdd:PRK11551 89 LFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAW 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 175 RTLFFT-AVAPALVCLALRPWVPESPSWLAAQAGRQRPgaapqshaeaggAGPLGRMLGDPETRGMFLLWslTSCFL-LF 252
Cdd:PRK11551 169 RHIFYVgGVGPLLLVPLLMRWLPESRAFAQAAGAGKQR------------APVLRALFGEGRATATLLLW--ISYFFtLI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 253 GYYGTNNWMPSYLESElGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAfmPLIVFYHSPSNILW 332
Cdd:PRK11551 235 VLYFLLNWLPSLLVGQ-GLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGILA--SLAALAAAPSFAGM 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 333 ILITFG---FIYGVPvGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLathvsIGAGflvMGITYVLTGLI 409
Cdd:PRK11551 312 LLAGFAaglFVVGGQ-SVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQL-----LALG---RSTVGVIGASI 382
|
....*.
gi 15596216 410 PALFIA 415
Cdd:PRK11551 383 PVILVA 388
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
21-415 |
6.80e-27 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 111.66 E-value: 6.80e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 21 IAFVFCFLglladgvDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGT 100
Cdd:TIGR00893 1 LVTVINYL-------DRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 101 ALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFT 180
Cdd:TIGR00893 74 GLQAFAGAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFII 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 181 AVAPAL----VCLALRPWVPESPSWLAAQAGRQRPGAAPQSHAEAGGAGP----LGRMLGDPETRGMFLLWSLTScfllF 252
Cdd:TIGR00893 154 EGVLGIiwgvLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPkkyqIKELLKDRRVWGLALGQFLVN----I 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 253 GYYGTNNWMPSYLESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRR---LTFA--AGAIGSAAFMPLIVFYHSp 327
Cdd:TIGR00893 230 GLGFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRgksLVFArkTAIIAGLVLSLLMFATNY- 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 328 SNILWILITF---GFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYV 404
Cdd:TIGR00893 309 VNIPYAALALvalGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALA 388
|
410
....*....|.
gi 15596216 405 LTGLIPALFIA 415
Cdd:TIGR00893 389 LIGALSYLLLV 399
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-421 |
5.47e-26 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 108.81 E-value: 5.47e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 1 MNATALSPNPAPAISRRTMLIAFVFCFLGLladGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCC 80
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNL---RPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 81 DRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRyRTTILAAMQAGWTVGYLV 160
Cdd:COG2807 78 RRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAAL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 161 ATLLAGQIIPEFGWRTLFFTAVAPALVCLAlrPWVPespswlaaQAGRQRPGAAPqshaeAGGAGPLGRMLGDPetrgmf 240
Cdd:COG2807 157 AAGLTVPLAAALGWRGALAVWALLALLALL--LWLP--------LLRRRPAAAAA-----APAAASLRSLWRSP------ 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 241 LLWSLTSCFLL--FGYYGTNNWMPSYLEsELGMNfKSMTGYMVGTYSAM-ILGKVAAGVCADLFGRRLTFAAGAIGSAAF 317
Cdd:COG2807 216 LAWLLTLFFGLqsLLYYAVVAWLPPILR-DAGLS-AATAGLLLSLFQLAgIPGSLLVPLLADRLGDRRPLLLLLGLLGLA 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 318 MPLIVFYHSPSNILWILITFGFIYGVPVGVLATYMTESF-STRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHV-SIGAG 395
Cdd:COG2807 294 GLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRArTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATgSWTAA 373
|
410 420
....*....|....*....|....*.
gi 15596216 396 FLVMGITYVLTGLIPALFIADRLYDP 421
Cdd:COG2807 374 LLLLAALAVLMLVAGLLAGRPYVEDA 399
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
4-413 |
3.62e-25 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 107.79 E-value: 3.62e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 4 TALSPNPAPAISRRTMLI----AFVFCFLGL---------LADGVDLMFLAYS--LNSLKAEFGL---SNFEAGSLGSLT 65
Cdd:TIGR00898 57 LPRLPDGRPESCLRFMVDqwanPSLLGCEPLklsdlglaaTEPCLDGWEYSYDtfSSTIVTEWDLvceDAWKVDLTQSCF 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 66 LAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTT 145
Cdd:TIGR00898 137 FVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAI 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 146 ILAAMQAGWTVGYLVATLLAGQIIPefgWRTLFFTAVAPALVCLALRPWVPESPSWLAAQAGRQRPGAAPQSHAEAGGAG 225
Cdd:TIGR00898 217 VGTLIQVFFSLGLVLLPLVAYFIPD---WRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKK 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 226 PLGRMLGDPETRG------------MFLLWSLTSCFLL---------FGYYGTnnwmpSYLESELGMNFksmtgYMVGTY 284
Cdd:TIGR00898 294 LPAEVLSLSLEKDlssskkqysfldLFRTPNLRKTTLClmmlwfttaFSYYGL-----VLDLGNLGGNI-----YLDLFI 363
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 285 SAM--ILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPVGVLATYM--TESFSTRV 360
Cdd:TIGR00898 364 SGLveLPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLytAELYPTVV 443
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 15596216 361 RGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGflVMGITYVLTGLIPALF 413
Cdd:TIGR00898 444 RNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLV--LFGGLALLAGILTLFL 494
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
11-256 |
5.49e-23 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 98.34 E-value: 5.49e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 11 APAISRRTMLIAFVFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVT 90
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 91 WTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIP 170
Cdd:COG0477 84 IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 171 EFGWRTLFFTAVAPALVCLALRPWVPESPSWLAAQAGRQRPGAAPQSHAEAGGAGPLGRMLGDPETRGMFLLWSLTSCFL 250
Cdd:COG0477 164 ALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLL 243
|
....*.
gi 15596216 251 LFGYYG 256
Cdd:COG0477 244 ALLLLA 249
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
63-405 |
5.55e-23 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 100.81 E-value: 5.55e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 63 SLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGL---TQNYWQFALIRFVASLGLGSLFVACNILMSECVG 139
Cdd:pfam00083 53 SIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAakgKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAP 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 140 TRYRTTILAAMQAGWTVGYLVA---TLLAGQIIPEFGWRTLFFTAVAPALVCLALRPWVPESPSWLAAQAGRQR------ 210
Cdd:pfam00083 133 KKLRGALGSLYQLAITFGILLAyifGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEarevla 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 211 -------------PGAAPQSHAEAGGAGPLGRMLGDPETRGMFLLWSLTSCFLLFGYYGTNNWMPSYLESELGmnfksMT 277
Cdd:pfam00083 213 klrgvpdvdreldEIKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLG-----LS 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 278 GYMVGTYSAMILgKVAAGVCA----DLFGRRLTFAAGAIGSAAFM--PLIVFYHSPSNILW---ILITFGFIYG-----V 343
Cdd:pfam00083 288 DSFLVTIIVGVV-NFVFTFIAiflvDRFGRRPLLLLGAAGMAICFviLGIVALLGVSKSDWagiVAIVFIALFIaffamG 366
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596216 344 PVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIG------AGFLVMGITYVL 405
Cdd:pfam00083 367 WGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGytffifAGLLVLFIIFVF 434
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
66-409 |
3.79e-22 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 96.88 E-value: 3.79e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 66 LAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTT 145
Cdd:cd17317 35 FLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 146 ILAAMQAGWTVGYLVATLLAgQIIPEfgWRTLFFTAVAPALVCLALRPWVPESpswlaaqagrqrpgaapqshaeaggag 225
Cdd:cd17317 115 VGILFGLFWALGYMLLALLA-YLIRD--WRWLQLAISLPGLLFLLLLWWLPRR--------------------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 226 plgrmlgdpeTRGMFLLWSLTScfllFGYYGTnnwmpSYLESELGMNFKSMTGYMVGtysAMILGKVAAGVCADLFGRRL 305
Cdd:cd17317 165 ----------TIIVGLIWFVTS----LVYYGL-----SLNSSNLGGNLYLNFFLSGL---VEIPAYFLALLLLDRLGRRW 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 306 TFAAGAIGSAAFMPLIVFYHSPSNILWILI----------TFGFIYgvpvgvlaTYMTESFSTRVRGSAVGTAYNLGRIG 375
Cdd:cd17317 223 TLSGSLLLAGLACLVTALLPDDENTLALTLalvgkfaisaAFSVIY--------LYTAELYPTVVRNTGVGLCSTVARVG 294
|
330 340 350
....*....|....*....|....*....|....
gi 15596216 376 AAVAPAgIGLLaTHVSIGAGFLVMGITYVLTGLI 409
Cdd:cd17317 295 AILAPF-IVLL-GKIGPLLPLIIFGVLALLGGLL 326
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
26-409 |
1.26e-20 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 93.09 E-value: 1.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 26 CFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGL 105
Cdd:cd17393 4 VAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 106 TQNYWQFALIRFVASLGLGSLFVACNILMSEcVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPA 185
Cdd:cd17393 84 APSVPALALALFLFGAANGALDVAMNAQGVA-VERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 186 LVCLALrpwvpesPSWLAAQAGRQRPGAAPQSHAEAGGAGPLGRMLgdpetrgmfLLWSLTSCFLLFGYYGTNNWMPSYL 265
Cdd:cd17393 163 LLLAAL-------VAIRALLPGTGEAAEDRPDGAGKPGFLLPNRLL---------LLLGLLALAAALAEGAAADWSALYL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 266 ESELGMNFKSMT-GYMVGTySAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSP--SNILWILITFGFIYG 342
Cdd:cd17393 227 RDVLGASAALAAlGYAVFS-LAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVwvALAGFALMGLGLSVV 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596216 343 VPVgvlATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGLI 409
Cdd:cd17393 306 VPL---AFSAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALL 369
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
27-405 |
2.26e-20 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 92.23 E-value: 2.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 27 FLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLT 106
Cdd:cd17324 5 ALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 107 QNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLF-FTAVAPA 185
Cdd:cd17324 85 PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFlAIAVLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 186 LVCLALRPWVPESPswlaaqagrqrpgaaPQSHAEAGGAGPLGRMLGDPETRGMFLLwsltSCFLLFGYYGTNNWMPSYL 265
Cdd:cd17324 165 LAALLLWRLLPSLP---------------PKKPGSLGLLSSLLLLLRNPRLRLAYLI----TFLLFGGFFALYTYLAPFL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 266 ESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPV 345
Cdd:cd17324 226 TDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAH 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 346 GVLATYMTESfSTRVRGSAVG---TAYNLG-RIGAAVApagiGLLATHVS------IGAGFLVMGITYVL 405
Cdd:cd17324 306 SALQTRVLRL-APEARGLASSlylAAYNLGgALGAALG----GLVLDHGGwagvgwVGAALLLLALLLAL 370
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
20-414 |
5.34e-20 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 91.09 E-value: 5.34e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 20 LIAFVFCFLGLLAdGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIG 99
Cdd:cd17359 1 LISLVAALGGLLF-GYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFIS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 100 TALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSEC--------VGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPE 171
Cdd:cd17359 80 ALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVapaeirgrLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 172 FGWRTLFFTAVAPALVCLALRPWVPESPSWLAAQaGRQrpgaapqshaeaggAGPLGRMLGdpetrgmfLLWSLTSCFLL 251
Cdd:cd17359 160 EGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSK-GKP--------------ILIIGIGLA--------IFQQFVGINVI 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 252 FgYYGTNNWmpsyleSELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYH------ 325
Cdd:cd17359 217 F-YYGPEIF------QNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISLLLIGTAFyfapgs 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 326 --SPSNILWILITFGFIYGVPVGVLATYM-TESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGIT 402
Cdd:cd17359 290 qaSGIVALVLILLFVAFFAMSWGPVTWVLlSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGLAFTFLIFAVI 369
|
410
....*....|..
gi 15596216 403 YVLTGLIPALFI 414
Cdd:cd17359 370 CVLAFLFVWKFV 381
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
71-413 |
7.03e-20 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 91.05 E-value: 7.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 71 VGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQ--------FALIRFVASLGLGSLFVACNILMSECVGTRY 142
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQigilapilLVLLRLLQGLALGGEWGGAVLMAVEHAPPKR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 143 RTTILAAMQAGWTVGYLVAT---LLAGQIIPE-----FGWRTLFFTAVAPALVCLALRPWVPESPSWLAAQAGRQRPgAA 214
Cdd:cd17369 139 RGFYGSFPQLGAPVGLLLATgvfLLLSALLSDeaflsWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVV-RA 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 215 PqshaeaggagPLGRMLGDPET--RGMFLLWSLTSCFLLFGYYGTnnwmpSYLESELGMNFKSMTGYMVGTYSAMILGKV 292
Cdd:cd17369 218 P----------LVEVLRRHWRAllLAIGLRLAENVLFYLFTTFAL-----SYATQTLGVDRSTVLLAVLIASVVAAITIP 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 293 AAGVCADLFGRRLTFAAGAIGSA----AFMPLIVFYHSPSNILWILITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTA 368
Cdd:cd17369 283 LFGWLSDRVGRRPVYLAGALLAAlfafPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLG 362
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 15596216 369 YNLGRI-GAAVAP-AGIGLLATHVSIGAGFLVMGITYVLTgLIPALF 413
Cdd:cd17369 363 YQLGAIlGGGFAPlIATALVAATGSWWPVALYLAALAVIS-LVAALF 408
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
43-409 |
4.58e-17 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 82.23 E-value: 4.58e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 43 SLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLG 122
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 123 LGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGqIIPEFGWRTLFFTAVAPALVCLALRPWVPESPSwl 202
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGG-LLAAISWRYPFFLLAALIPVAFLAILFLLPEPK-- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 203 aaqagrqrpgaapqSHAEAGGAGPLGRMLGDPETRGMFLLwSLTSCFLLFGYYGTNNWMPSYLESELGMNfKSMTGYMVG 282
Cdd:cd17474 178 --------------EKAKSSSATKLRDLKKALRGRGLLTF-LVSAFLYFFLYFAFLTYLPFLLELLYGIS-PIIIGLLFA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 283 TYS-AMILGKVAAG-VCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPVGVLATYMTESFSTRV 360
Cdd:cd17474 242 GWSvLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEE 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 15596216 361 RGSAVGtAYN-LGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGLI 409
Cdd:cd17474 322 RGTASS-LYNfVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
46-408 |
2.49e-16 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 80.01 E-value: 2.49e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 46 SLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGS 125
Cdd:cd17312 28 PIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSM 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 126 LFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFF-TAVAPALVCLALRPWVPESPSWLaa 204
Cdd:cd17312 108 GWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLvPGIVGLVVAIILFFFLRDSPPYV-- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 205 qagrqrpgaapqshaeaggagplgrmlgdpetrgmfLLWSLTSCFLLFGYYGTNNWMPSYLESELGMNFKSMTGYMVGTY 284
Cdd:cd17312 186 ------------------------------------WVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 285 SAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFM-PLIVFYHSPSNILW---ILITFGFIYGVPVGVLATYMTESFSTR- 359
Cdd:cd17312 230 VGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTlSLALFWFFPHNKLLsivLLFLIGFFVGGPINLIGGAAAQDIGRKe 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 15596216 360 VRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGL 408
Cdd:cd17312 310 AAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVL 358
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
43-406 |
3.93e-16 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 79.54 E-value: 3.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 43 SLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLG 122
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 123 LGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLALR-PWVPESpsw 201
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVlLFLPET--- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 202 LAAQAGRQRPGAAPQSHaeaggagplGRMLGDPEtrgmFLLWSLTSCFLLFGYYGTNNWMPSYLESELGMNFKSMTGYMV 281
Cdd:cd17320 178 LPEEKRKPLLSSLLRAY---------KRVLKNRR----FLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 282 GTYSAMILGKVAAGVCADLFG-RRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPVGVL---ATYMTESFS 357
Cdd:cd17320 245 LNAIALILGSLLNGRLVRRFGpRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIfpnATSLALEPF 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 15596216 358 TRVRGSA---VGTAYNLGrIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLT 406
Cdd:cd17320 325 PHVAGTAsalLGFLQFLI-GALAGALVGLLPNGTALPMGLLILVLGLLALLL 375
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
28-199 |
4.98e-16 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 79.16 E-value: 4.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 28 LGLLADGVDLMFLAYSLNSLKAEF--GLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGL 105
Cdd:cd17315 4 LGGLLFGYDLGVINGALLYIAKDLgfGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 106 TQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATL--LAGQIIPEFGWRTLFFTAVA 183
Cdd:cd17315 84 APNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLlgLALSLSPPGWWRLMFALAAV 163
|
170
....*....|....*.
gi 15596216 184 PALVCLALRPWVPESP 199
Cdd:cd17315 164 PALLQLLLMFFLPESR 179
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
26-405 |
1.97e-15 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 77.36 E-value: 1.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 26 CFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGL 105
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 106 TQNYWQFALIRFVASLGLGSLFVACNILMSEcVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPA 185
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGA-LFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 186 LVCLALRPWVPESPswlaaqagrQRPGAAPQSHAEAGGAGPLGRMLGDPETrgmfllwsLTSCFLLFGYYGTN----NWM 261
Cdd:cd17333 160 YLLLAILILLTLFP---------ELPSARNPQQSVGAFSASASRLLRNPSI--------ILGALALFLYVGAEtafsSWV 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 262 PSYLESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIY 341
Cdd:cd17333 223 PSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFM 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596216 342 GVPVGVLATYmTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVL 405
Cdd:cd17333 303 AALFPTILSL-GISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAI 365
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
27-396 |
2.39e-15 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 77.42 E-value: 2.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 27 FLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLT 106
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 107 QNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEF-GWRTLFF----TA 181
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIvpgiIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 182 VAPALVCLALRPWVPESPSWLAAQagrQRPGAAPQSHAEAGGAGPLGRMLGDPETRGMFLLW--SLTSCFLLFGYYGTNN 259
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAE---EMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWyiSLGYVFVYVVRTGILD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 260 WMPSYLESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAA-FMPLIVFYHSP-SNILWILI-- 335
Cdd:TIGR00881 238 WSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALiIVSLLVYWLNPaANPLMDLIcl 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596216 336 -TFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGF 396
Cdd:TIGR00881 318 fALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
23-392 |
2.89e-15 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 76.80 E-value: 2.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 23 FVFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTAL 102
Cdd:cd17372 1 LAYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 103 LGLTQNYWQFALIRFVASLGLGSLFVACnILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAV 182
Cdd:cd17372 81 SAFAPNYMWLIILRCLVGLGLGGGPQLA-SWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 183 APALVCLALRPWVPespsWLAAQAGRQRPGAAPQSHaeaggagplGRMLGDPEtrgmfLLWSLTSCFLLFGYYGTNNWMP 262
Cdd:cd17372 160 VPSSLLLVFYRWTP----KTTLLLWVIWFGNAFAYY---------GVVLLTTE-----LNNSHNVCGSKSDSDSGESPTE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 263 SYLESELGMNFKSMTGYMVGTYSAMILGkvAAGVcaDLFGRRLTFAAgAIGSAAFMPLIVFYHSPSNILWILITFGFIY- 341
Cdd:cd17372 222 KQCRNSNDVDYRDVFIATFAEFPGLLIS--AAMI--DRLGRKASMAS-MLFTCCIFLLLLLICQSPFILTVLLFGGRACi 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 15596216 342 GVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAP-AGIGLLATHVSI 392
Cdd:cd17372 297 SAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPfIAQVLVHGSQTI 348
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
23-202 |
5.55e-15 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 76.89 E-value: 5.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 23 FVFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTAL 102
Cdd:cd17438 1 FFVLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 103 LGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFG--------- 173
Cdd:cd17438 81 SSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGwgfsmgtny 160
|
170 180 190
....*....|....*....|....*....|...
gi 15596216 174 ----WRTLFFTAVAPALVCLALRPWVPESPSWL 202
Cdd:cd17438 161 hfhsWRVFVIICALPCIASIIALKFMPESPRFL 193
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-191 |
6.64e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.08 E-value: 6.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 14 ISRRTMLIAFVFCFLGLLADGVDLMFLAYSLNSLkaeFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTI 93
Cdd:cd17325 196 LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAEL---GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 94 VLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFG 173
Cdd:cd17325 273 LLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
|
170
....*....|....*...
gi 15596216 174 WRTLFFTAVAPALVCLAL 191
Cdd:cd17325 353 FATPFLAAAALLLLAAVL 370
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
71-371 |
9.11e-15 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 75.79 E-value: 9.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 71 VGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNY-----WQFALI---RFVASLGLGSLFVACNILMSECVGTRY 142
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYatigiWAPIILllaRLLQGLSVGGEYGTSATYLSEVAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 143 R--------TTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLALRPWVPESPSWLAAQAGRQRPgaa 214
Cdd:cd17367 135 RgfyssfqyVTLIGGQLLALGVLLVLQHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEAS--- 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 215 pqshaeaggAGPLGRMLGDPetRGMFLLWSLTSCFLLFgYYGTNNWMPSYLESELGMNFKSMTGYMVGTYSAMILGKVAA 294
Cdd:cd17367 212 ---------AGTLRELRRHP--RELLLVVGLTAGGTLA-FYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLG 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 295 GVCADLFGRRLTFAAGAIGSAAFMPLIVFY----HSPSNILWILITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYN 370
Cdd:cd17367 280 GRLSDRIGRRPLLLFFGIGGTLATVPLLSAldhtDSPYTAFALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYA 359
|
.
gi 15596216 371 L 371
Cdd:cd17367 360 L 360
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
49-414 |
1.04e-14 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 75.39 E-value: 1.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 49 AEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFV-ASLGLGSLF 127
Cdd:cd17355 31 AEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLlGGGGAGTLA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 128 VACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTlffTAVAPALVCLALrpwvpespSWLAAQAG 207
Cdd:cd17355 111 AVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRT---ALLVLALLALLV--------LVPVLLLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 208 RQRPGAAPQSHAEAGGAGPLGRMLGDPETRGMFLLWSLTSCFLLFGYYGTNNWMPSYLEsELGMNFKSMTGYMVGTYSAM 287
Cdd:cd17355 180 RRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLA-DRGISPAAAAVALALIGLFN 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 288 ILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWI-LITFGFIYGVPVGVLATYMTESFSTRVRGSAVG 366
Cdd:cd17355 259 IVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLfAALFGLGWGATVPLTAALAARYFGARSYGTLFG 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 15596216 367 TAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGLIPALFI 414
Cdd:cd17355 339 LVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
23-341 |
3.02e-14 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 74.19 E-value: 3.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 23 FVFCFLGLLaDGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTAL 102
Cdd:cd17328 2 AVLFLINLL-NYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 103 LGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILA----AMQAGWTVGYLVATLLAGQIIpefGWRTLF 178
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGvfyfAIPLGSGLGYVVGGLVAQATG---GWRWAF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 179 FTAVAPALVCLALRPWVPESPswlaaqagrqRPGAAPQSHAEAGGAGPLGRMLGDPETRGMFLLWSLTSCFLLFGYYGTN 258
Cdd:cd17328 158 RVTGVLGVLLAILLLLFVREP----------PRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 259 NWMPSYLESELGMNFKSMT----GYMVGTYSAMILGKVAAGVCADLFGRR------LTFAAGAIGSAAFMpLIVFYHSPS 328
Cdd:cd17328 228 FWAPTFFLRAFGVGDLSSAdvglIFGAITCIAGVLGVLLGGILADRLRRKtpradpLVCAVGLLAAAPFL-FLALVLALS 306
|
330
....*....|...
gi 15596216 329 NILWILITFGFIY 341
Cdd:cd17328 307 NLLLAWVLLFLGE 319
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
71-372 |
3.11e-14 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 73.95 E-value: 3.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 71 VGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNY-----WQFALI---RFVASLGLGSLFVACNILMSECVGTRY 142
Cdd:cd17368 55 IGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYatigiAAPLLVllaRLLQGFAAGGEVGGVTAYLVEAAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 143 R--------TTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLALRPWVPESPSWLAAQAgrqrpgaa 214
Cdd:cd17368 135 RgfytswqsASQQVAIVAGALVGYLLSLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKA-------- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 215 pqsHAEAGGAGPLGRMLGDPETRGMFLLWSLTSCFLLFGYYgtnnwMPSYLESELGMNFKSMTGYMVGTYSAMILGKVAA 294
Cdd:cd17368 207 ---RPTRRELFALLANNRRIILLGMLLVAGSTVTFYFTTVY-----TPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 295 GVCADLFGRR----LTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYN 370
Cdd:cd17368 279 GALSDRIGRRpvllVITLAALVTLYPVFAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYA 358
|
..
gi 15596216 371 LG 372
Cdd:cd17368 359 LA 360
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
47-401 |
3.56e-14 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 73.74 E-value: 3.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 47 LKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSL 126
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 127 FVACNILMSECVGTRyRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLalrpwvpespsWLAAQA 206
Cdd:cd17478 102 HPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVA-----------LLLLRL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 207 GRQRPGAAPQSHAEAGGAGPLGRMLgdpetRGMFLLWSLTSCFLLFgYYGTNNWMPSYLESELGmnFKSMTGYMVGTYS- 285
Cdd:cd17478 170 RPLKKPEAKKAAAKSSARSTLKGVW-----RALLLLLIIVFLRSWV-LSSLTTFLPFYLVQRGY--SLVFAGLLLSLFLf 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 286 AMILGKVAAGVCADLFGRRLTFAAGAIGSAAFmpLIVFYHSPSNILWILIT-FGFIYGVPVGVLATYMTESFSTRVrGSA 364
Cdd:cd17478 242 AGAIGTLIGGPLSDRFGRRRVIIASLLLAAPF--LLLFLLTPGIWSYILLVlAGFLLFASFPVTVVLAQELLPGNV-GLA 318
|
330 340 350
....*....|....*....|....*....|....*..
gi 15596216 365 VGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGI 401
Cdd:cd17478 319 SGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILAL 355
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
50-409 |
5.55e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 73.01 E-value: 5.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 50 EFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVA 129
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 130 CNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLALRPWVPESPSwlaaqagrq 209
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPP--------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 210 rpgaapqshaEAGGAGPLGRMLGDPETRGMFLLWSLTSCFLLFGYYGTNNWMPSYLESELGmnfkSMTGYMVGTYS-AMI 288
Cdd:cd17489 176 ----------VAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGI----SNAGLFFTVYAiALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 289 LGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTA 368
Cdd:cd17489 242 LSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTF 321
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15596216 369 YNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGLI 409
Cdd:cd17489 322 FIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
28-202 |
1.25e-13 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 73.09 E-value: 1.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 28 LGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQ 107
Cdd:TIGR01299 174 LALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQ 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 108 NYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFG-------------W 174
Cdd:TIGR01299 254 GYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGwsfqmgsayqfhsW 333
|
170 180
....*....|....*....|....*...
gi 15596216 175 RTLFFTAVAPALVCLALRPWVPESPSWL 202
Cdd:TIGR01299 334 RVFVIVCAFPCVFAIGALTFMPESPRFF 361
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
52-370 |
1.93e-13 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 71.51 E-value: 1.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 52 GLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALI-RFVASLGLGSLFVAC 130
Cdd:cd17356 41 YPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYQLIVgRIIAGLGVGFASVLV 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 131 NILMSECVGTRYRTTILAAMQAGWTVGYLVATLL---AGQIIPEFGWRTLFFTAVAPALVCLALRPWVPESPSWLaaqag 207
Cdd:cd17356 121 PVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCInygTHKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWL----- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 208 rQRpgaapqshaeaggagplgRMLGdpetrGMFLLWSLTSCFLLFGYYGTnnwmpsYLESELGMNFKSmtgymvGTYSAM 287
Cdd:cd17356 196 -YR------------------TILG-----IMLQLFQQLTGINYFFYYGT------TIFQSTGLTGSS------PLLTSI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 288 ILGKVAAGVCA------DLFGRRLTFAAGAIGSAAFMPLIVFY---------------HSPSNILWILI-TFGFIYGVPV 345
Cdd:cd17356 240 ILYIVNFVSTIpglffvDKFGRRTCLLIGAAGMSICLFIYAAVgvrylipnpqsgtsnKSAGNGMIVFIcLFIFSFATTW 319
|
330 340
....*....|....*....|....*...
gi 15596216 346 GVLA-TYMTESFSTRVR--GSAVGTAYN 370
Cdd:cd17356 320 GPIAwVYVAEVFPLRVRskGMALATAFN 347
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
49-405 |
2.09e-13 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 71.05 E-value: 2.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 49 AEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFV 128
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 129 ACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGqIIPEFGWRTLFFTAVAPALVCLalrpwvpesPSWLAAQAGR 208
Cdd:cd17477 104 VSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA-LVGTAGALPFLIAAVLLLLALV---------PLLLTRRAAP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 209 QRPGAAPQSHAEAGGAGPLGrmlgdpetrgmfLLWSLTSCFLLFGYYGTnnwMPSYLeSELGMNFKSMTGYMVGTYSAMI 288
Cdd:cd17477 174 EIEEAESISLRRLLRIAPLA------------LLGAFVAGFLEGAFYSL---LPLYG-LRLGLSVAQAALLLAAFVLGGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 289 LGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITF--GFIYGV-PVGVlaTYMTESFSTRVRGSAV 365
Cdd:cd17477 238 LLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLwgGAAGPLyTLAL--ALAGDRLPGDELVAAN 315
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 15596216 366 GTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVL 405
Cdd:cd17477 316 AALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALL 355
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
53-342 |
3.59e-13 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 71.14 E-value: 3.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 53 LSNFEAGSLGSLTLAGMAVGGIYGGW----CCDRFGRVRVVTWTIVLFSIGTALLGL---TQNYWQFALIRFVASLGLGS 125
Cdd:cd17357 42 LSDSELDLLWSLIVSIFFIGGAIGSFisafLANRFGRKNGLLISNALLVVSSLLMFLsksAKSPELLIFGRFLVGIACGL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 126 LFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQII--PEFGWRTLFFTAVAPALVCLALRPWVPESPSWLA 203
Cdd:cd17357 122 STGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGLPSVlgTETLWPYLLFFPGIPALLQLAALPFFPESPKFLL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 204 AQAGRQ----------RPGAAPQSHAEA-----------GGAGPLGRMLGDPETR-GMFLLWSLTSCFLLFG-----YYG 256
Cdd:cd17357 202 ISKGDEeeaekslkflRGIEDDVDQELEeikkeseqmgdQKQVSLMQLLRDPSLRlPLLLVLVVSASQQFSGinaifFYS 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 257 TNNWMPSYLESELGM--NFKSMTGYMVGTYSAMILgkvaagvcADLFGRR----LTFAAGAIGSAAFMPLIVFYHSPSNI 330
Cdd:cd17357 282 TFIFENAGFSPQLAEwaNLGIGIVNVLSTIVGPFL--------IEKVGRRplllISLSVCAVALLLMSVFLFLSEQNSWM 353
|
330
....*....|..
gi 15596216 331 LWILITFGFIYG 342
Cdd:cd17357 354 SYGCIVAIFLFI 365
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
50-368 |
4.01e-13 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 70.68 E-value: 4.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 50 EFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVA 129
Cdd:cd17358 35 SLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 130 CNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLaGQIIPefgWRTLFFTAVAPALVCLALRPWVPESPSWLAAQAGRQ 209
Cdd:cd17358 115 VPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVL-GSFLP---WRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 210 RPGAAPQS--------------------HAEAGGAGPLGRMLGDPET-RGMFLLWSLTSCFLLFGYYGTNNWMPSYLEsE 268
Cdd:cd17358 191 EAEKSLQFlrgkdadiskeaaeiqeelaELEKEAKESSFSDLFQRKYlKPLVIGLGLMLFQQLSGINAVIFYASSIFD-E 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 269 LGMNFKSMTGYMVgTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFY---------HSPSNILWILITFGF 339
Cdd:cd17358 270 AGSGLDPNTATII-IGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALGLYfylqehgalLSSVSWLPLVGLVIY 348
|
330 340 350
....*....|....*....|....*....|..
gi 15596216 340 IYGVPVGVLA---TYMTESFSTRVRGSAVGTA 368
Cdd:cd17358 349 IISFSIGLGPlpwVIMSEIFPAKIKGLAGSLV 380
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
28-277 |
1.09e-12 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 69.56 E-value: 1.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 28 LGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQ 107
Cdd:cd17440 6 MALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 108 NYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFG-------------W 174
Cdd:cd17440 86 GYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfsmgsayqfhsW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 175 RTLFFTAVAPALVCLALRPWVPESPSWL--------AAQAGRQRPGAAPQSHAEAGGAGPLGRMLGDpETRGMFLLWSLT 246
Cdd:cd17440 166 RVFVIVCALPCVSSVVALTFMPESPRFLlevgkhdeAWMILKQIHDTNMRARGQPEKVFTVNRIKKD-NTIKLTIVWLTL 244
|
250 260 270
....*....|....*....|....*....|.
gi 15596216 247 ScfllFGYYGTNNWMPSYLESelgMNFKSMT 277
Cdd:cd17440 245 S----FGYYGLSVWFPDVIKH---LQFKSVT 268
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
28-202 |
1.23e-12 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 69.44 E-value: 1.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 28 LGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQ 107
Cdd:cd17363 6 LALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 108 NYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFG-------------W 174
Cdd:cd17363 86 GYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHYGwgfsmgtayqfhsW 165
|
170 180
....*....|....*....|....*...
gi 15596216 175 RTLFFTAVAPALVCLALRPWVPESPSWL 202
Cdd:cd17363 166 RVFVIVCALPSVASVVALTFMPESPRFL 193
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
28-414 |
2.09e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 68.37 E-value: 2.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 28 LGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQ 107
Cdd:cd17503 3 LGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 108 NYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALV 187
Cdd:cd17503 83 NLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGIL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 188 CLALRPWVPEspswlaaqagrqrpgaapqshaeaggagplgRMLGDPetrgMFLLWSLTSCFLLFGYYGTNNWMPSYLES 267
Cdd:cd17503 163 ALLLAPLLDL-------------------------------RLFKDR----NFTLGLLLSFLLGLGLFGAMFLLPLYLQN 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 268 ELGMNfKSMTGYMVGTYS-AMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNiLWILITFGFIYGVPVG 346
Cdd:cd17503 208 VLGYS-AFESGLVLAPGGlASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTS-LWLIILPLFIRGLGMG 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 347 -VLATYMTESFST----------------RVRGSAVGTAY----------NLGRIGAAVAPAGIGLLATHVSIGAGFLVM 399
Cdd:cd17503 286 lVFMPLNTLALNSlppeqigdatalfntiRQLGGSIGTALlatlltnrtqFHHSRLSELLAQQVQKQALIIAFNDAFLVS 365
|
410
....*....|....*
gi 15596216 400 GITyVLTGLIPALFI 414
Cdd:cd17503 366 AIL-LLVGLLLALFL 379
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
47-405 |
2.18e-12 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 68.43 E-value: 2.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 47 LKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGL-TQNYWQFALIRFVASLGLGS 125
Cdd:cd17341 25 IRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALaVSSYWGLLVLGFLLGFAGAN 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 126 lFVACNILMS-----ECVGTryrttiLAAMQAGW-----TVGYLVATLLAGQII---PEFGWRTLFFTAVAPALVCLALr 192
Cdd:cd17341 105 -FASGQPWASfwfpkEKIGG------AAGGIAGAgnmgvAVSQLLAPLIAGAIVfdgGFVGWRNAFFVPGILLAIAAVL- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 193 pwvpespSWLAAQAGRQRPGAAPQSHAEAGGAgplgrmLGDPETRGMFLLWSLTscfllFG-YYGTNNWMPSYLESELGM 271
Cdd:cd17341 177 -------VLLFGDDLPTGKASALEFLKVQLAV------LKNYRTWILSLLYGVT-----FGsFVGFSNVLPTYFKTRFGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 272 NFKSMTGYMVGTYSAMILGKVAAGVCADLFG-RRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPVGVL-- 348
Cdd:cd17341 239 PLVTAGILAALFPLAGALARPAGGWLSDRFGgRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGng 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15596216 349 ATY-MTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIG-AGFLVMGITYVL 405
Cdd:cd17341 319 SVFrMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGvGAFSLFGVLAVA 377
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
63-389 |
2.62e-12 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 67.70 E-value: 2.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 63 SLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRY 142
Cdd:cd17374 42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRH 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 143 RTTILAAMQAGWTVGYLVATLLAgQIIPEfgWRTLFFTAVAPALVCLALRPWVPEspswlaaqagrqrpgaapqshaeag 222
Cdd:cd17374 122 RALAITLTSCFFSIGQMLLAGLA-YAIRD--WRLLQLVVSVPFFLFFLYSWWLPK------------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 223 gagplgrmlgdpETRGMFLLWSLTScfllFGYYGTNNWMpsyleSELGMNFkSMTGYMVGtySAMILGKVAAGVCADLFG 302
Cdd:cd17374 174 ------------RTLILSFVWFANS----FSYYGLSLDL-----QHLGLNV-FLLQFLFG--AVEVPARCLALFLLNHMG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 303 RRLTFAAGAIGSAAFMPLIVFYHSPSNILWILI-TFG-FIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAP 380
Cdd:cd17374 230 RRISQAVLLLLAGLCILANIFVPQEMQTLRTVLaVLGkGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAP 309
|
....*....
gi 15596216 381 AgIGLLATH 389
Cdd:cd17374 310 L-IMLLGVY 317
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
29-414 |
7.10e-12 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 66.53 E-value: 7.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 29 GLLADGVDLMFLAYSLNSLKAEFG-----LSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALL 103
Cdd:cd17364 7 GFFTDAYDLFSISLVTKILGRLYYggkgsLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 104 GLTQN------YWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAgQII-------- 169
Cdd:cd17364 87 ALSPGstplgvMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVT-LILsaifehpl 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 170 -------PEFGWRTLFFTAVAPALVCLALRpwvpespswlaaqagrqrpgaapqshaeaggagplgrmlgdpetrgMFLL 242
Cdd:cd17364 166 pagtyhhADLVWRIVLGLGAIPALSVLYFR----------------------------------------------KHLL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 243 WSLTSCFLL-FGYYGTN----------NWMPSYLESELGmnFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAAGA 311
Cdd:cd17364 200 GTAGTWFLLdIAFYGQNlfqstiisaiGFSKTMNAYQEL--FNIAVGQLIIALAGTVPGYWFTVFLIDRIGRKKIQMMGF 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 312 IGSAAFMPLI-VFYHSP--SNILWIL---ITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGL 385
Cdd:cd17364 278 FGMTIFLLILaGPYDHWkiSTIGFFVlygLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLS 357
|
410 420
....*....|....*....|....*....
gi 15596216 386 LATHVSIGAGFLVMGITYVLTGLIPALFI 414
Cdd:cd17364 358 LTQNIGVRNVLIILAGVALLGIILTLLFP 386
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
47-386 |
7.19e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 66.49 E-value: 7.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 47 LKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSL 126
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 127 FVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFftaVAPALVCLALrpwvpespSWLAAQA 206
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAF---VVAGLVSILA--------AVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 207 GRQRPGAAPQSHAEAGGAGPLGRMLGDPEtrgmFLLWSLTSCFLLFGYYGTNNWMPSYLESELGMNFKSMTGYMVGTYSA 286
Cdd:cd17475 171 YREPPAASAATESASTLLRSLKEVLRNRD----VWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 287 MILGKVAAGVCAD--LFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPV----GVLATYMTESFSTRV 360
Cdd:cd17475 247 GALGRIGLGRVSDrvFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAigwnGLYLTLVAESAGPEQ 326
|
330 340
....*....|....*....|....*.
gi 15596216 361 RGSAVGTAYNLGRIGAAVAPAGIGLL 386
Cdd:cd17475 327 AGTALGLANTINFIGIAIGPPLFGLL 352
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
28-199 |
7.49e-12 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 66.98 E-value: 7.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 28 LGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQ 107
Cdd:cd17439 6 LALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 108 NYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFG-------------W 174
Cdd:cd17439 86 GYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfqmgsayqfhsW 165
|
170 180
....*....|....*....|....*
gi 15596216 175 RTLFFTAVAPALVCLALRPWVPESP 199
Cdd:cd17439 166 RVFVLVCAFPSVFAIGALTTMPESP 190
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
28-198 |
1.11e-11 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 65.99 E-value: 1.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 28 LGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQ 107
Cdd:cd17441 6 LAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 108 NYWQFALIRFVASLGLGSLFVACNiLMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALV 187
Cdd:cd17441 86 IYSWILVLRGLVGFGIGGVPQSVT-LYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLI 164
|
170
....*....|.
gi 15596216 188 CLALRPWVPES 198
Cdd:cd17441 165 FAVLCFWLPES 175
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
50-409 |
1.59e-11 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 65.65 E-value: 1.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 50 EFGLSNFEAGSLGSLT-LAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVAsLGLGSLFV 128
Cdd:cd17471 26 ELGASPLQIGIFMTLSaLSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVL-LSLGAAAF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 129 ACNILMS----ECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLALRPWVPESPSwlaa 204
Cdd:cd17471 105 PQLFALAreyaDRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVK---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 205 qagRQRPGAAPQSHAEAGGAGPLgrmlgdpetrgmfLLWSLTSCFLLFG---YYGTNnwMPSYLESELGMNfKSMTGYMV 281
Cdd:cd17471 181 ---PPAQKATPASSLVKAPVNRR-------------LLLLFAAFTLLFAansMYIIA--MPLYVTNELGGS-ESWVGLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 282 GTYSA-----MILgkvaAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPVGVLATYMTESF 356
Cdd:cd17471 242 GLAAAleipiMLL----AGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLM 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15596216 357 STRVrGSAVgTAY-NLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGLI 409
Cdd:cd17471 318 PGQP-GLAT-TLYsNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVL 369
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
71-380 |
1.66e-11 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 65.89 E-value: 1.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 71 VGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNY-----WQ---FALIRFVASLGLGSLFVACNILMSECVGTRY 142
Cdd:PRK10642 72 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigiWApilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 143 RTTILAAMQAGWTVGY--------LVATLLAGQIIPEFGWRTLFFTAVAPALVCLALRPWVPESPSWlaaqagRQRPGAA 214
Cdd:PRK10642 152 RGFMGSWLDFGSIAGFvlgagvvvLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAF------QQHVDKL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 215 PQSHAEAGGAGPlGRMLGDPETRGmfllW-SLTSCFLL-----FGYYGTNNWMPSYLESELGMNFKSMTGYMVGTYSAMI 288
Cdd:PRK10642 226 EQGDREGLQDGP-KVSFKEIATKH----WrSLLTCIGLviatnVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGML 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 289 LGKVAAGVCADLFGRRLTFAAGAIGSAAF-MPLIVFYHSPSN--ILWILITFGFIYGVPVGVLATYMTESFSTRVRGSAV 365
Cdd:PRK10642 301 FVQPVMGLLSDRFGRRPFVILGSVALFVLaIPAFILINSNVIglIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSAL 380
|
330
....*....|....*
gi 15596216 366 GTAYNLGRIGAAVAP 380
Cdd:PRK10642 381 AAAFNISVLVAGLTP 395
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
28-203 |
2.22e-11 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 65.21 E-value: 2.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 28 LGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQ 107
Cdd:cd17436 8 LGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 108 NYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLL--AGQIIPEfGWRTLFFTAVAPA 185
Cdd:cd17436 88 SFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALnyFFSNVLT-GWRYMFGLAIIPA 166
|
170
....*....|....*...
gi 15596216 186 LVCLALRPWVPESPSWLA 203
Cdd:cd17436 167 AIQFASILLLPKKPEVLN 184
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-415 |
2.30e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 65.31 E-value: 2.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 8 PNPAPAISRRTMLIafvFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCD----RF 83
Cdd:COG2211 1 TAAKKKLSLKEKLA---YGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRW 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 84 GRVR-VVTWTIVLFSIGTALL------GLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGT-RYRTTILAAMQAGWT 155
Cdd:COG2211 78 GRRRpWILIGAIPLALSFVLLftapdlSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 156 VGYLVATLLAGQIIPEF------GWRTLFFTAVAPALVCLalrpwvpespsWLAAQAGRQRPGAAPQshaeaggAGPLGR 229
Cdd:COG2211 158 LGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAF-----------LLTFFGTKERPVPEEE-------KVSLKE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 230 MLGDPETRGMFLLWSLTSCFLLFGYYGTNNWMPSYLESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAA 309
Cdd:COG2211 220 SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 310 GAIGSAAFMPLIVFYHSPSniLWILITFGFIYGVPVGVLAT-----------YMTESFSTRVRGSAVGTAYNLGRIGAAV 378
Cdd:COG2211 300 GLLLAALGLLLLFFLGPGN--LWLLLVLAALAGIGLGAILVlpwamladvvdYDEWKTGRRREGLYFGIFTFAIKLGQAL 377
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 15596216 379 APAGIGLLATHVSIGAGFL-----VMGITYVLTgLIPALFIA 415
Cdd:COG2211 378 AGALAGLLLALFGYVAGAAqspsaLTGIRLLFF-LLPAVLLL 418
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
38-409 |
2.53e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 64.94 E-value: 2.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 38 MFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRF 117
Cdd:cd17329 17 MVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 118 VASLGLGSLFVACNILMSECVGTRYRTTILA----AMQAGWTVGYLVATLLAgqiipEFGWRTLF-FTAVAPALVCLALR 192
Cdd:cd17329 97 LTGFGGGLFEPASEAMIADVTTPENRTRAFSllywAINLGVAIGPLLGGLLL-----LYSFRLLFlAAAVLFLLAALVLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 193 PWVPEspswlaaqagRQRPGAAPQSHAEAGGAGPLGRmlgdpetRGMFLLWSLTSCFLLFGYYGTNNWMPSYLeSELGMN 272
Cdd:cd17329 172 FLLPE----------TRPKRRAAEKTEILRGYKIVLR-------DRAFLLFLLASFLISLIYFQLESTLPVYV-VEILGL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 273 FKSMTGYMVGTYSAMI-LGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNIL--WILITFGFIYGVPvgVLA 349
Cdd:cd17329 234 GESLLGLLLALNALLIvLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLIlaMIVLTLGEMLVFP--AVQ 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 350 TYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGLI 409
Cdd:cd17329 312 TLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
54-409 |
3.14e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 64.56 E-value: 3.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 54 SNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGL-----TQNYWQFALIRFVASLGLGSLFV 128
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 129 ACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLALRPWVPESPswlaaqagR 208
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPP--------P 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 209 QRPGAAPQSHAEAGGAGpLGRMLGDPETRGMFLLWSLTscFLLFGYYGTNnwMPSYLESELGMNfKSMTGYMVGTYSA-M 287
Cdd:cd06173 184 AAPGESSSLLLRDLREG-LRYLRRSPLLRLLLLALALF--ALLGGALTVL--LPLLAKEVLGGG-AAGYGLLLAAFGVgA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 288 ILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFyhspSNILWILITFGFIYGVPVGV----LATYMTESFSTRVRGS 363
Cdd:cd06173 258 LLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL----SPSLWLLLAALFLLGLAGGLfnvpLNTLLQLRVPDELRGR 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 15596216 364 AVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGLI 409
Cdd:cd06173 334 VFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALL 379
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
53-214 |
4.13e-11 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 64.51 E-value: 4.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 53 LSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNI 132
Cdd:cd17433 38 LDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 133 LMSECVGTRYRTTILAAMQAGWTVGYLVAtLLAGQIipeFGWRTLFFTAVAPALVCLALRPWVPESPSWLAAQAGRQRPG 212
Cdd:cd17433 118 YISEIAHPRVRGTLGSCVQLMVVIGIMGA-YLAGLV---LDWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAM 193
|
..
gi 15596216 213 AA 214
Cdd:cd17433 194 AA 195
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
63-364 |
5.15e-11 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 64.28 E-value: 5.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 63 SLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLT---QNYWQFALIRFVASLGLGSLFVACNILMSECVG 139
Cdd:TIGR00879 78 SIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAafaLSVEMLIVGRVLLGIGVGIASALVPMYLSEIAP 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 140 TRYRTTILAAMQAGWTVGYLVA---TLLAGQIIPEFGWRTLFFTAVAPALVCLALRPWVPESPSWLA-----AQAGRQRP 211
Cdd:TIGR00879 158 KALRGALTSLYQLAITFGILVAygfGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVgkgrvEEARKSLA 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 212 GAAPQSHAEAGGA-------------GPLGRMLGDPE-TRGMFLLWSLTSCFLLFG-----------YYGTnnwmpsYLE 266
Cdd:TIGR00879 238 RLRGTSGEDKELLdelelidikrsieKRSVQPSWGSLfSSTRRIRRRLFLGVVLQWfqqftginaimYYSP------TIF 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 267 SELGMnfkSMTGYMVGTYSAMILGkVAAGVCA----DLFGRRLTFAAGAIGSAAFMPLIVFY------HSPSNILWILIT 336
Cdd:TIGR00879 312 ENAGV---STDHAFLVSIIVGAVN-FAFTFVAiflvDRFGRRPLLLIGAAGMAICLFVLGILgasfvtGSSKSSGNVAIV 387
|
330 340 350
....*....|....*....|....*....|...
gi 15596216 337 FGFIYGV-----PVGVLATYMTESFSTRVRGSA 364
Cdd:TIGR00879 388 FILLFIAffamgWGPVPWVIVSEIFPLSLRPKG 420
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
24-380 |
1.40e-10 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 62.52 E-value: 1.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 24 VFCFLG--LLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTA 101
Cdd:cd17442 2 LFLIMGstGVAEAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 102 LLGLTQNYWQFALIRFVASLGLgSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTA 181
Cdd:cd17442 82 LTSFAPSYIWFVFLRCMVGCGV-SGHSQGLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 182 VAPALVCLALRPWVPESP-----SWLAAQAGRQrpgAAPQSHAEAGGAGPLGRMLGDPETRGMFLLWSLTSCFllfgyyg 256
Cdd:cd17442 161 SIPGIILIVVFKFIPRTTlqiwvIWLGISFAYY---GVILASSELLERNLLCGSDPSDEEAGIKHIESESPCY------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 257 TNNWMPSyleselgmNFKSMTGYMVGTYSAMILGKVAagvcADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILIT 336
Cdd:cd17442 231 CHMFNPS--------DYQTMIISTLGEIALNPLNILG----INFLGRRLSLVITMGLTAIFFLLLNICTSSAGLTIFLFM 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 15596216 337 FGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAP 380
Cdd:cd17442 299 LRALVSANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAP 342
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
44-201 |
1.40e-10 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 62.67 E-value: 1.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 44 LNSLKAEFG---LSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVAS 120
Cdd:cd17360 20 LLYIKDDLGevvLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 121 LGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQI--IPEfGWRTLFFTAVAPALVCLALRPWVPES 198
Cdd:cd17360 100 LGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFsyLPG-GWRWMLGLAAVPAVLQFIGLLFLPES 178
|
...
gi 15596216 199 PSW 201
Cdd:cd17360 179 PRW 181
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
27-414 |
3.37e-10 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 61.04 E-value: 3.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 27 FLGLLADGVDLMFLAYSLNSLKAEFGLSNfEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLT 106
Cdd:cd17502 2 MLALFLAALDQTIVATALPTIVAEFGGLS-LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 107 QNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPAL 186
Cdd:cd17502 81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 187 VCLALRPwvpespswlaaqagrqrpgaapqshaeaggagplgrmlgdpetrgMFLLWSLTSCFLLFGYYGTNNWMPSYLE 266
Cdd:cd17502 161 LALALLR---------------------------------------------TILLSSIFGFLFGGALFGLIYYLPLYFQ 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 267 SELGMNfKSMTGYMVGTYS-AMILGKVAAGVCADLFGR--RLTFAAGAIGSAAFMPLIVFYHSPSNILWI--LITFGFIY 341
Cdd:cd17502 196 LVLGDS-ATKSGVRLLPLIiGLVIGSIISGALISKTGRykPLIVIGTILMSVGAGLLTTLTLDTSKWLLIgyLILLGLGL 274
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15596216 342 GVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVApagigllathVSIGAGFLVMGITYVLtGLIPALFI 414
Cdd:cd17502 275 GIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLG----------VAITDVFLVALALAAL-AFLLSLFL 336
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
17-191 |
6.79e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 60.66 E-value: 6.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 17 RTMLIAFVFCFLGLLAdgvdlmFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGG-IYGGWCCDRFGRVRVVTWTIVL 95
Cdd:cd17474 201 LTFLVSAFLYFFLYFA------FLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSlFVGRLLKKRFGARRILVIGLLL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 96 FSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWR 175
Cdd:cd17474 275 YALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLS 354
|
170
....*....|....*.
gi 15596216 176 TLFFTAVAPALVCLAL 191
Cdd:cd17474 355 APFLVGAAIALAAAVL 370
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
28-390 |
1.17e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 59.88 E-value: 1.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 28 LGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQ 107
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 108 NYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALV 187
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 188 CLALRPwvpespswlaaqagrqrpgaapqshaeaggagplgrmlgdpetrgMFLLWSLTSCFLLFGYYGTNNWMPSYLES 267
Cdd:cd17321 163 ALLLAR---------------------------------------------TFSGAVLAAFLLGAALGGLLFLLPLYLQG 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 268 ELGMNfKSMTGYMVGTYS-AMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPS---NILWILITFGFIYGV 343
Cdd:cd17321 198 VLGYS-PLQAGLALLPLAlAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSsvwLLLPGLVLLGLGLGL 276
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 15596216 344 PVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHV 390
Cdd:cd17321 277 FATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
67-191 |
1.42e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 56.12 E-value: 1.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 67 AGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTI 146
Cdd:TIGR00880 9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVA 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 15596216 147 LAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLAL 191
Cdd:TIGR00880 89 LGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIL 133
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
64-371 |
2.17e-09 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 58.91 E-value: 2.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 64 LTLAGMAV-------GGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFA--------LIRFVASLGLGSLFV 128
Cdd:cd17366 41 ATFATFAVaflvrplGGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTYATIGvwapilllLARMVQGFSTGGEYG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 129 ACNILMSECVGTRYRTTILAAMQAGWTVGY--------LVATLLAGQIIPEFGWRTLFFTAVAPALVCLALRPwvpesps 200
Cdd:cd17366 121 GAATFVAEYAPDRKRGFLGSWLEFGTLAGFilgaglvtLLTLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLRR------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 201 wlaaqagrqrpgaapqshaeaggagPLGRMLGdpetrgMFLLWSLTscfllfgYYGTNNWMPSYLESELGMNFKSMTGYM 280
Cdd:cd17366 194 -------------------------PLLICIG------LVLVFNVT-------NYMLLSYMPSYLEETLGYSETHGLLVI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 281 VGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFM-PLIVFYHSPS--NILWILITFGFIYGVPVGVLATYMTESFS 357
Cdd:cd17366 236 IIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAvPAFLLMNSGSiaAIFIGLLVLGLLLSCYTATMASTLPALFP 315
|
330
....*....|....
gi 15596216 358 TRVRGSAVGTAYNL 371
Cdd:cd17366 316 THVRYSALAIAFNI 329
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
41-205 |
2.48e-09 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 59.32 E-value: 2.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 41 AYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLF---SIGTA---LLGLTQN------ 108
Cdd:PRK10077 40 TVFVAPQNLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFfisALGSAwpeFGFTSIGpdntgy 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 109 YWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILA----AMQAGWTVGYLVATLLAG----QIIPEFGWRTLFFT 180
Cdd:PRK10077 120 VPEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSfnqfAIIFGQLVVYFVNYFIARsgdaSWLNTDGWRYMFAS 199
|
170 180
....*....|....*....|....*
gi 15596216 181 AVAPALVCLALRPWVPESPSWLAAQ 205
Cdd:PRK10077 200 EAIPALLFLMLLYFVPETPRYLMSR 224
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
233-415 |
3.10e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.34 E-value: 3.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 233 DPETRGMFLLWSLTSCFLLFGYYGTNNWMP--SYLESELGMNfKSMTGYMVGTYS-AMILGKVAAGVCADLFGRRLTFAA 309
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVaaPPLQADLGLS-AAQLGLLASAFFlGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 310 GAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATH 389
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180
....*....|....*....|....*.
gi 15596216 390 VSIGAGFLVMGITYVLTGLIPALFIA 415
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRFWLLA 186
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
244-429 |
3.61e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.20 E-value: 3.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 244 SLTSCFLLFGYYGTNNWMPSYLESELGMNfKSMTGYMVGTYS-AMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIV 322
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGIS-PTEIGLLLTLFSlGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 323 FYHSPSNILWILITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGIT 402
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180
....*....|....*....|....*..
gi 15596216 403 YVLTGLIPALFIADRLYDPNRESRDAE 429
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEAR 187
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
17-327 |
4.20e-09 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 58.08 E-value: 4.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 17 RTMLIAFVFCFLGLLadgVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLF 96
Cdd:TIGR00886 1 RNLFFSWFGFFLSFL---VWFAFSPLAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 97 SIGTALLGL-TQNYWQFALIRFVASLGLGSlFVACNILMSECVGTRYRTTILaAMQAGW-----TVGYLVATLLAGQIIP 170
Cdd:TIGR00886 78 AIPCLWAGLaVQSYSVLLLIRLFIGIAGGS-FASCMPWISFFFPKKIQGTAL-GLAAGWgnmggGVAQFVMPPIIGSLIF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 171 E--------FGWRTLFFTAVAPALVCLALrpwvpeSPSWLAAQAGRQRPGAAPQSHAEAGgagplgrmLGDPETRGMFLL 242
Cdd:TIGR00886 156 GggqpahlaWGWAFVIVPAGILLLPALLI------FFVGADTPPGKPATGKLSFKEALKV--------FGNRHTWILALL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 243 WSLTscfllFG-YYGTNNWMPSYLESELGMNfKSMTGYMVGTYSAM-ILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPL 320
Cdd:TIGR00886 222 YSVT-----FGsFLGVSSIFAMLFKDQFGLS-KVQAGAYASLGGFLgSLARPAGGAISDRLGGARKLLMNFLGVAMGAFL 295
|
....*..
gi 15596216 321 IVFYHSP 327
Cdd:TIGR00886 296 VVLGLVS 302
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
43-414 |
4.48e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 57.97 E-value: 4.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 43 SLNSLKAEFGLSNFEAG-SLGSLTLAGMAVGGIYGgWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASL 121
Cdd:cd17504 18 ALPTIQREFGTSAAAVSwVLTAYLLVGAVSTPILG-RLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 122 GLGsLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLALRPWVPEspsw 201
Cdd:cd17504 97 GGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDL---- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 202 laaqagrqrpgaapqshaeaggagplgRMLGDPETrgmfLLWSLTSCFLLFGYYGTNNWMPSYLES--ELGMNFKSMTG- 278
Cdd:cd17504 172 ---------------------------RLLRRRNV----LLANITALLAGFGMFMVFQLLPQLLQLptPTGFGLGITEAg 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 279 -YMVGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFI-YGVPVGVLATYMTESF 356
Cdd:cd17504 221 lLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIgLGLAFASLPNIVVESV 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596216 357 STRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIG-------------AGFLVMGITYVLtGLIPALFI 414
Cdd:cd17504 301 PPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSitsggvptegayvLAFLIGAALALA-ALLLSLLI 370
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
27-405 |
6.70e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 57.20 E-value: 6.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 27 FLGLLADGVDLMFLaYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLT 106
Cdd:cd17330 6 FLDALGFGIVFPVL-PFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 107 QNYWQFALIRFVASLgLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWR-TLFFTAVAPA 185
Cdd:cd17330 85 RNLWLLFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYAlPFLVAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 186 LVCLALRPWVPespswlaaqagrqrpgaapqshaeaggagPLGRMLgdpetrgmfllwsLTSCFLLFGYYGTNNWMPSYL 265
Cdd:cd17330 164 LNLVLVLFFLP-----------------------------PLRRLL-------------LVYFLIALAFAGLESVFSLFL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 266 ESELGMNfKSMTGYM--VGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGV 343
Cdd:cd17330 202 KDRFGFS-PSQIGLLlaLVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGI 280
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596216 344 PVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVL 405
Cdd:cd17330 281 VFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLI 342
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
63-200 |
1.15e-08 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 56.87 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 63 SLTLAGMaVGGIYGGWCCDRFGRvRVVTWTI-VLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTR 141
Cdd:cd17361 59 SLYLAGL-VASLLASYVTRKWGR-KPSMLIGgVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAK 136
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596216 142 YRTTILAAMQAGWTVGYLVATLL--AGQIIPEFGWRTLFFTAVAPALVCLALRPWVPESPS 200
Cdd:cd17361 137 LRGALNIGFQLAITIGILIANLInyGTSKIKPNGWRLSLGLAAVPALILLLGSLFLPETPN 197
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
74-409 |
1.18e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.78 E-value: 1.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 74 IYGGWCCDRFG-RVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTT---ILAA 149
Cdd:cd17370 52 LFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKafgLHRA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 150 M-QAGWTVGYLVATLLAgqIIPEFGWRTLFFTAVAP---ALVCLALRPWVPESPSWLAAQAGRQRPGAAPQShaeaggag 225
Cdd:cd17370 132 LdTLGAVLGPLLAALLL--YLLGGNYRTIFLLAAIPallALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKA-------- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 226 plgrmlgdpetrgmFLLWSLTSCFLLFGYYgtNNWMPSYLESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRL 305
Cdd:cd17370 202 --------------FWLYLLAVALFALGNF--SFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKK 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 306 TFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPVGVLATYMTESFSTRVRGSAVGtAYNLGR-IGAAVAPAGIG 384
Cdd:cd17370 266 LLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYG-LFNTVVgIGWLLASLIAG 344
|
330 340
....*....|....*....|....*
gi 15596216 385 LLATHVSIGAGFLVMGITYVLTGLI 409
Cdd:cd17370 345 YLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
77-409 |
1.19e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 1.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 77 GWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTV 156
Cdd:cd17473 56 GWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 157 GYLVATLLAGQIIpEFGWRTLFFtAVAPALVCLALrpwvpespSWLAAQAGRQRPGAAPQSHAEAGGAGPLGRMlgdpet 236
Cdd:cd17473 136 GGVVFLLLGGALA-EIGWRAPFL-VYLLALPVLIL--------VLLFLPEPARKSKSAASPGAATAAALPWKRV------ 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 237 rgmfLLWSLTSCFLLFGYYGTNNWMPSYLESELGMNfKSMTGYMVgtySAMILGKVAAGVCADLFGRRLTFAAGAIGSAA 316
Cdd:cd17473 200 ----LPIYFLAFLAMLLFYVIPIQLPFLLQERGGGS-AALIGLAL---AIASLAGAIGALLFGRLKRRLGKRRLLAIGFA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 317 FMPL--IVFYHSPSNILWIL--ITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLAT-HVS 391
Cdd:cd17473 272 LMALgfLLLALASGLWVVLLgaILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNlTGG 351
|
330
....*....|....*...
gi 15596216 392 IGAGFLVMGITYVLTGLI 409
Cdd:cd17473 352 LSGAFLILGVLALVLAIV 369
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
37-201 |
1.20e-08 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 56.59 E-value: 1.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 37 LMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIR 116
Cdd:cd17362 20 LLSITSPALSGTDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGR 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 117 FVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLA-GQIIPEFGWRTLFFTAVAPALVCLALRPWV 195
Cdd:cd17362 100 LIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGyAFADVVGGWRYMYGLAAPPALLLGIGMWFL 179
|
....*.
gi 15596216 196 PESPSW 201
Cdd:cd17362 180 PPSPRW 185
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
237-434 |
1.78e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.04 E-value: 1.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 237 RGMFLLWSLTSCFLLFGYYGTNNWMPSYLESELGMNfKSMTGYMVGTYSAM-ILGKVAAGVCADLFGRRLTFAAGAIGSA 315
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLS-AAQLGLLFAIPVLVgALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 316 AfmPLIVFYHSPSniLWILITFGFIYGVPVG----VLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVS 391
Cdd:COG2223 82 I--GLLLLALAVS--YWLLLLLGLLLGIGGGgsfaVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 15596216 392 IGAGFLVMGITYVLTGLIPALFIADRLYDPNRESRDAESASRR 434
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE 200
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
20-409 |
2.05e-08 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 56.02 E-value: 2.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 20 LIAFVFCFLGLLADGVDLMFLAYsLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGrVRVVTWT-IVLFSI 98
Cdd:cd17352 3 VVVFASFLVNFFTDGILNSFGVL-FVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFG-CRPVAIAgGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 99 GTALLGLTQNYWQFAL-IRFVASLGLGSLFVACnILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWR-- 175
Cdd:cd17352 81 GLLLSSFATSLWQLYLtYGVLGGLGLGLIYSPA-IVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRga 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 176 TLFFTAVapALVCLAlrpwvpespswlaaqagrqrpgaapqshaeaggAGPLGRMLGDPetrgMFLLWSLTSCFLLFGYY 255
Cdd:cd17352 160 LLILGGL--CLNLCV---------------------------------CGLLLRLLKDP----TFVLLALGVSFAMLGFF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 256 GTNNWMPSYLESeLGMNfKSMTGYMVGTYSAM-ILGKVAAGVCADL--FGRRLTFAAGAIGSAAFMPLIVFYHSPSNILW 332
Cdd:cd17352 201 VPFVYLPSYAKS-LGID-ESDAAFLLSIIGISdIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIV 278
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596216 333 ILITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHV-SIGAGFLVMGITYVLTGLI 409
Cdd:cd17352 279 FSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTgDYDAAFYFCGACLLLSGVL 356
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
53-202 |
2.86e-08 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 55.80 E-value: 2.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 53 LSNFEAGSLGSLTLAGMAVGGIYG----GWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALI---RFVASL--GL 123
Cdd:cd17431 43 ISPETLTTLWSLSVAIFSVGGMIGsfsvGLFVNRFGRRNSMLYNNLLAFAGAALMGLSKLAKSYEMLilgRFIIGLycGL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 124 GSLFVAcnILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQII--PEFGWRTLFFTAVAPALVCLALRPWVPESPSW 201
Cdd:cd17431 123 TTGLVP--MYIGEISPTALRGALGTLHQLGIVVGILISQIFGLEFIlgTEELWPLLLGFTIVPAILQLALLPFCPESPRY 200
|
.
gi 15596216 202 L 202
Cdd:cd17431 201 L 201
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
243-434 |
4.21e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.89 E-value: 4.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 243 WSLTSCFLLFGYYGTNNWMPSYLESeLGMNfKSMTGYMVGTYS-AMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLI 321
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAES-LGAS-VAQIGLIVAAYAlAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 322 VFYHSPsnilWILITFGFIYGVPVGVLAT----YMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFL 397
Cdd:cd17325 79 AFATSY----WQLLLARFLQGLASAAVWPaamaLIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFL 154
|
170 180 190
....*....|....*....|....*....|....*..
gi 15596216 398 VMGITYVLTGLIPALFIADRLYDPNRESRDAESASRR 434
Cdd:cd17325 155 VCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSG 191
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
72-195 |
4.88e-08 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 54.67 E-value: 4.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 72 GGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQ 151
Cdd:cd17378 50 SGVLGHLADSSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPKWRGQVGMSTF 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 15596216 152 AGWTVGYLVATLLAgqIIPEFGWRTLFF-TAVAPALVCLALRPWV 195
Cdd:cd17378 130 FFFVLGFMSLPGIA--YLNGSSWRVLYFwTSIPALIYCILVYLFA 172
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
5-191 |
2.05e-07 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 53.00 E-value: 2.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 5 ALSPNPAPAISRRTMLIAFVFCFLGLLADGVDLMFLAYSLNSLKAE-FGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRF 83
Cdd:PRK09874 2 SPCENDTPINWKRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTgHSALNMWSGLVFSITFLFSAIASPFWGGLADRK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 84 GRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLgLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATL 163
Cdd:PRK09874 82 GRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPL 160
|
170 180
....*....|....*....|....*...
gi 15596216 164 LAGQIIPEFGWRTLFFTAVAPALVCLAL 191
Cdd:PRK09874 161 AGGLLADSYGLRPVFFITASVLFLCFLV 188
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
63-196 |
3.98e-07 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 51.65 E-value: 3.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 63 SLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRY 142
Cdd:cd17446 40 SIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRV 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 15596216 143 RTTILAAMQAGWTVGYLVATLLAGQIIPefgWRTLFFTAVAPALVCLALRPWVP 196
Cdd:cd17446 120 RAVVGTLLGYCYTLGQLILAGVAYAIRD---WRWLQLAVSLPFFIFFLYSWWFP 170
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
241-412 |
4.08e-07 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 51.86 E-value: 4.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 241 LLW--SLTSCFLLFGYYGTNNWMPSYLESELGMNFK-SMTGYMVGTYSAmILGKVAAGVCADLF--GRRLtfAAGAIGSA 315
Cdd:cd17345 232 LLWyiAIANVFVYLVRYGILDWAPTYLSEVKGFSKAqAMWAFSLFEWAA-IPGTLLAGWLSDKLfkGRRA--PTGIIFMI 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 316 AFMPLIVFYHSPSNILWILITFG----FIYGvPV---GVLATYMTESFSTrvrGSAVGTAYNLGRI-GAAVAPAGIGLLA 387
Cdd:cd17345 309 LVIVALIVYWLAPNVLVDLIALIalgfLIYG-PVmliGLQALELVPKKAA---GTAAGLTGLFGYLgGSVLATALIGIIV 384
|
170 180
....*....|....*....|....*
gi 15596216 388 THVSIGAGFLVMGITYVLTGLIPAL 412
Cdd:cd17345 385 DHFGWNGGFIVLLASCILAIIFLAL 409
|
|
| PRK03633 |
PRK03633 |
putative MFS family transporter protein; Provisional |
30-305 |
5.20e-07 |
|
putative MFS family transporter protein; Provisional
Pssm-ID: 179614 [Multi-domain] Cd Length: 381 Bit Score: 51.58 E-value: 5.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 30 LLADGVDLMFLAYS-LNSLK----AEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLG 104
Cdd:PRK03633 10 LLLCGLLLLTLAIAvLNTLVplwlAQEHLPTWQVGVVSSSYFTGNLVGTLLAGYVIKRIGFNRSYYLASLIFAAGCAGLG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 105 LTQNYWQFALIRFVASLGLGSLFVAC-NILMseCVGT-RYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGwrtlfftAV 182
Cdd:PRK03633 90 LMVGFWSWLAWRFVAGIGCAMIWVVVeSALM--CSGTsRNRGRLLAAYMMVYYLGTVLGQLLVSKVSTELM-------SV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 183 APALVCLALRPWVPESPSWLAAQAGRQRPgaapqshaeaggAGPLGRMLGDPETRgMFLLWSLTSCFLLFGYYGTnnwMP 262
Cdd:PRK03633 161 LPWVTGLVLAAILPLLFTRILNQQAENHD------------STSIWPMLKLRQAR-LGVNGCIISGIVLGSLYGL---MP 224
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 15596216 263 SYLeSELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRL 305
Cdd:PRK03633 225 LYL-NHQGMSDASIGFWMALLVSAGILGQWPIGRLADRFGRLL 266
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
16-191 |
5.68e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.46 E-value: 5.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 16 RRTMLIAFVFCFLGLladgvdlMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVL 95
Cdd:cd06173 211 RLLLLALALFALLGG-------ALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 96 FSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWR 175
Cdd:cd06173 284 LGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363
|
170
....*....|....*.
gi 15596216 176 TLFFTAVAPALVCLAL 191
Cdd:cd06173 364 AVFLLAGALLLLAALL 379
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
234-414 |
6.34e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.13 E-value: 6.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 234 PETRGMFLLWSLTSCFLLFGYYGTNNWMPsYLESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAAGAIG 313
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 314 SAAFMPLIVFYHSPSNILWILITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIG 393
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180
....*....|....*....|.
gi 15596216 394 AGFLVMGITYVLTGLIPALFI 414
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
67-180 |
6.59e-07 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 51.20 E-value: 6.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 67 AGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTI 146
Cdd:cd17379 44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTV 123
|
90 100 110
....*....|....*....|....*....|....
gi 15596216 147 LAAMQAGWTVGYLVATLLAgQIIPEFGWRTLFFT 180
Cdd:cd17379 124 GIVYQMFFTLGLLILPGIA-YFIPHWRWLQLAVT 156
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
67-380 |
9.65e-07 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 50.50 E-value: 9.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 67 AGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTI 146
Cdd:cd17447 46 AGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 147 LAAMQAGWTVGYLVATLLAGQIipeFGWRTLFFTAVAPALVCLALRPWVPEspswlaaqagrqrpgaapqshaeaggagp 226
Cdd:cd17447 126 GVLISLFWTVGNMLLALVAYLI---RDWRWLILAVTLPCAPGIITWWWVPK----------------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 227 lgrmlgdpetrgMFLLWSLTSCFLLFGYYGTnnwmpSYLESELGMNFkSMTGYMVGTYSamILGKVAAGVCADLFGRRLT 306
Cdd:cd17447 174 ------------ISLCTGIVWFGVAFTYYGI-----SFNISGFGLNV-YLTQFIYGAIE--LPAKLLAYLLLDRIGRRLT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 307 FAAGAIGSAAFMPLIVF----YHSPSNILWIL------ITFGFIYgvpvgvlaTYMTESFSTRVRGSAVGTAYNLGRIGA 376
Cdd:cd17447 234 QAGSLILTGLSIGINILipseFTVVRTVIAVLgkgfseAAFTTVF--------LYTSELYPTVLRQNGMGYTSFIARLGG 305
|
....
gi 15596216 377 AVAP 380
Cdd:cd17447 306 SLAP 309
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
49-328 |
2.26e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 49.48 E-value: 2.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 49 AEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLT--QNYWQFALIRFVASLGLGSL 126
Cdd:cd17380 27 KEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLaySSLPLLILSRILLGLGEGVH 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 127 FVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALV-CLALRPWVPEspswlaaq 205
Cdd:cd17380 107 FPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLwALVWLIYLPP-------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 206 agrqrpgaapqshaeaggagplgrmlgdpetrgmflLWSLTSCFLLF--GYYGTNNWMPSYLESELGmNFKSMTGYMVGT 283
Cdd:cd17380 179 ------------------------------------VWAIIVAHFCMnwGFYILLSWLPTYFHEVLV-PLAKGWVFNVVP 221
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 15596216 284 YSAMILGKVAAGVCAD---------LFGRRLTFAAGAIGSAAFMPLIVFYHSPS 328
Cdd:cd17380 222 WLVMFPSSNVAGWLADhlisrgwtvTSVRKLMQSIGFLGPALFLLLLSHTDSFS 275
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
43-196 |
2.53e-06 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 49.39 E-value: 2.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 43 SLNSLKAEFGL---SNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTI---VLFSIGTallGLTQNYWQFALIR 116
Cdd:cd17377 23 SFTSIVSEWFLvgnAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLaldILFAYFN---ALAPSYEFFAVSR 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 117 FVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPefgWRTLFFTAVAPALVCLALRPWVP 196
Cdd:cd17377 100 FLVGVMNGGMSLVAFVLLNECVGKSYWALAGSLGGLFFAVGIAQYALLGYFIRS---WRTLAVVVNLQGTLVFLLSLFIP 176
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
42-413 |
2.86e-06 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 49.26 E-value: 2.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 42 YSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFgRVRVvtwtivLFSIGTALLGLT-------QNYWQFAL 114
Cdd:cd17343 24 FVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQI-SARW------LFSSGLVLSGLTtvafsgsSSVWVFSI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 115 IRFVASLGLGSLFVAC-NILMSECVGTRYRT--TIL-AAMQAGWTVGYLVATLLAGQiipeFGWRTLF----FTAVAPAL 186
Cdd:cd17343 97 LWFLNGLAQGLGWPPCaKILRKWFSPSQFGTwwSVLsTSMNLAGSLGPILATLLALS----YGWRSTLsisgTVAVVMSV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 187 VCLALrpwVPESPSwlaaQAGRQRPGAAPQSHAEAG---GAGPLGRMLGDPetrgmfLLWSLTSCFLL-FGY-YGTNNWM 261
Cdd:cd17343 173 VCLLF---IKNEPS----DVGLNNIEEEESKGKKKKsprGESTLKELLLSP------FLWLLSLGYLVvFGVkTAVTDWG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 262 PSYLESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGR----------RLTFAAG-AIGSAAFMPLIVFY-HSPSN 329
Cdd:cd17343 240 QLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAkhgsssrgnpRMPLALVfMAGLTVSLHLFRVHiTSDSS 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 330 ILWILItFGFIYGVPV-------GVLAtymTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGIT 402
Cdd:cd17343 320 ELFILL-LGFLIGFSLygpiaifGVIA---NESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLLEIL 395
|
410
....*....|.
gi 15596216 403 YVLTGLIPALF 413
Cdd:cd17343 396 CAITVVILFLL 406
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
65-413 |
3.04e-06 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 49.34 E-value: 3.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 65 TLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALI------RFVASLGLGSLFVACNILMSECV 138
Cdd:TIGR00887 65 ASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMatlcfwRFWLGVGIGGDYPLSAIITSEFA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 139 GTRYRTTILA---AMQA-GWTVGYLVATLLA-----------------GQIIPEFG--WRTLFFTAVAPALVCLALRPWV 195
Cdd:TIGR00887 145 TKKWRGAMMAavfAMQGfGILAGAIVALIVLagfkhsleaaadeasctGSCVPAVDymWRILIGFGAVPALLALYFRLTI 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 196 PESPSWLAAQAGRQRPGAAPQS-------HAEAGGAGPLGRMLGDPET-------------RGMFLLWSLTSCFLL-FGY 254
Cdd:TIGR00887 225 PETPRYTADVAKDVEQAASDMSavlqvkiEAEPDEVEKASTAVEVPKAswsdffthffkwrHGKHLLGTAGSWFLLdIAF 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 255 YGTNNWMPS------YLESELGMN-FKSMTGYMVGTYSAMILGKV------AAGVcaDLFGRRLTFAAGAIGSAAFMPLI 321
Cdd:TIGR00887 305 YGVNLNQKVilsaigYSPPAATNNaYEELYKTAVGNLIIALAGTVpgywvtVFLV--DIIGRKPIQLMGFFILTVLFFVL 382
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 322 VF-YHSPSN----ILWILITFGFIYGvPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGF 396
Cdd:TIGR00887 383 GFaYNHLSThgflAIYVLAQFFANFG-PNATTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQHGDPTKGY 461
|
410
....*....|....*...
gi 15596216 397 -LVMGITYVLtgLIPALF 413
Cdd:TIGR00887 462 pTGIWMGHVL--EIFALF 477
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
63-189 |
3.55e-06 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 48.86 E-value: 3.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 63 SLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRY 142
Cdd:PRK10473 45 SVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRR 124
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 15596216 143 RTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFT-AVAPALVCL 189
Cdd:PRK10473 125 RAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTmAAMGILVLL 172
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
44-196 |
4.27e-06 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 48.55 E-value: 4.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 44 LNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGL 123
Cdd:PRK10091 26 LTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPH 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596216 124 GSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWR-TLFFTAVAPALVCLALRPWVP 196
Cdd:PRK10091 106 GAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRyTFLLIAVFNIAVLASIYFWVP 179
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
38-191 |
4.99e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 48.35 E-value: 4.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 38 MFLAYSLNS----LKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGL-TQNYWQF 112
Cdd:cd17365 184 LLLVYLLNSwlpkLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVsPASLVLL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 113 ALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQII-PEFGWRTLFFTAVAPALVCLAL 191
Cdd:cd17365 264 YVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLaAGLGPESVFLALAIPAALGALA 343
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
62-409 |
6.38e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 47.98 E-value: 6.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 62 GSLTLAGMAVGgIYG----------GWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVAslGLGSLFVACN 131
Cdd:cd17472 29 ATPTLIGLALG-IYGltqaifqipfGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQ--GSGAISSVVM 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 132 ILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLALRPWVpespswlaaqagrqRP 211
Cdd:cd17472 106 ALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFF--------------VP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 212 GAAPQSHAEAGGAGPLGRMLGDPETR-----GMFLLWSLTSCFLLFGYYGTNNWmpsYLESELGMNFKSMTGYmvgtysA 286
Cdd:cd17472 172 DPPKIVQISEKEKKKLKKLLKNKRLLrldfsIFILHFVLMAFFYILPLLLTQLG---GGKGQLWKVYLPAILI------G 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 287 MILGKVAAGVCADLFGRRLTFAAGAIG-SAAFMPLIVFYHSPSNILWILITF--GFIYGVPvgVLATYMTESFSTRVRGS 363
Cdd:cd17472 243 FILMVPFVIYAEKKGKMKQVFVSSILLiAVGFLLLLFAATSLWLLIIGLIIFfiGFNLLEA--LLPSLVSKIAPKEYRGT 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 15596216 364 AVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGLI 409
Cdd:cd17472 321 AMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLV 366
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
71-369 |
1.14e-05 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 47.42 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 71 VGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGL-----TQNYWQFALI---RFVASLGLGSLFVACNILMSECVGTRY 142
Cdd:PRK09952 79 LGGVVFGHFGDRLGRKRMLMLTVWMMGIATALIGLlpsfsTIGWWAPVLLvtlRAIQGFAVGGEWGGAALLAVESAPKNK 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 143 RTTILAAMQAGWTVGYLVATLLAGQII--------PEFGWRTLFFTAVAPALVCLALRPWVPESPSWLAAQagrqrpgaa 214
Cdd:PRK09952 159 KAFYSSGVQVGYGVGLLLSTGLVSLISmmttdeqfLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQ--------- 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 215 pQSHAEAGGAGPLGRMLGDpETRGMFLLWSLTSCFLLFGYYGTnNWMPSYLESELGM--NFKSMTGYMVGTYSAMILGKV 292
Cdd:PRK09952 230 -HEQAAAKKRIPVIEALLR-HPGAFLKIIALRLCELLTMYIVT-AFALNYSTQNLGLprELFLNIGLLVGGLSCLTIPCF 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 293 AagVCADLFGRRLTFAAGA-IGSAAFMPLIVFYHSPSnILWILITFGFIYGVP----VGVLATYMTESFSTRVRGSAVGT 367
Cdd:PRK09952 307 A--WLADRFGRRRVYITGAlIGTLSAFPFFMALEAQS-IFWIVFFSIMLANIAhdmvVCVQQPMFTEMFGASYRYSGAGV 383
|
..
gi 15596216 368 AY 369
Cdd:PRK09952 384 GY 385
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
63-191 |
1.24e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 47.18 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 63 SLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRY 142
Cdd:cd17323 41 SLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEE 120
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 15596216 143 RTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLAL 191
Cdd:cd17323 121 RGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLIL 169
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-162 |
1.85e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 46.64 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 23 FVFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTI---VLFSIG 99
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALlllILAALG 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15596216 100 TALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVAT 162
Cdd:pfam07690 282 LLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-191 |
2.06e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.44 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 14 ISRRTMLIAFVFCFLGLLADGVDLMFLAYslnsLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTI 93
Cdd:cd17316 175 LRRRTLLLILLWFFISFGYYGLTTFLPTY----LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 94 VLFSIGTALLG--LTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPE 171
Cdd:cd17316 251 ILSGILALPLFylLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330
|
170 180
....*....|....*....|
gi 15596216 172 FGWRTLFFTAVAPALVCLAL 191
Cdd:cd17316 331 TGGTGVPALILALLAIVALI 350
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
14-191 |
2.29e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 46.45 E-value: 2.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 14 ISRRTMLIAFVFCFlgllADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTI 93
Cdd:cd17353 211 RTPTFWLLWLMFFL----NATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAF 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 94 VLFSIGTALLGLTQ-NYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEF 172
Cdd:cd17353 287 LIQGVAMFLLPFIGsVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTG 366
|
170
....*....|....*....
gi 15596216 173 GWRTLFFTAVAPALVCLAL 191
Cdd:cd17353 367 GYNAAFIIAAALSLVALAL 385
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
58-199 |
2.51e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 46.42 E-value: 2.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 58 AGSLgSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSEc 137
Cdd:PRK11043 44 SASL-SLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVID- 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596216 138 vgtRYRTTilAAMQAGWTVGYLV------ATLLAGQIIPEFGWRTLFFTAVAPALVCLALRPWVPESP 199
Cdd:PRK11043 122 ---RYPAQ--KANRVFATIMPLValspalAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSK 184
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
24-215 |
2.53e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 46.14 E-value: 2.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 24 VFCFLGL-LADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTAL 102
Cdd:cd06180 1 LAGALALaVAMGIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 103 LGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPE-FGWRTLFF-T 180
Cdd:cd06180 81 MALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGgLSWRAGWLaL 160
|
170 180 190
....*....|....*....|....*....|....*
gi 15596216 181 AVAPALVCLALRPWVPESPSWLAAQAGRQRPGAAP 215
Cdd:cd06180 161 ALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLN 195
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
17-191 |
3.06e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 3.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 17 RTMLIAFVFCFLGLLADgVDLMFLAYSLnslkAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLF 96
Cdd:cd17370 200 KAFWLYLLAVALFALGN-FSFAFLILRA----QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 97 SIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRT 176
Cdd:cd17370 275 ALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSA 354
|
170
....*....|....*
gi 15596216 177 LFFTAVAPALVCLAL 191
Cdd:cd17370 355 AFLFSAVLALIALLL 369
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-191 |
5.35e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.11 E-value: 5.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 22 AFVFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWT-IVLFSIGT 100
Cdd:cd06174 205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIgLLLMALGL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 101 ALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPE-FGWRTLFF 179
Cdd:cd06174 285 ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFL 364
|
170
....*....|..
gi 15596216 180 TAVAPALVCLAL 191
Cdd:cd06174 365 VLAVLLLLAAIL 376
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
38-198 |
5.99e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 44.91 E-value: 5.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 38 MFLAySLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRF 117
Cdd:PRK11102 9 MYLP-ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 118 VASLGLGSLFVACNILMSECVG----TRYRTTILAAMqagwTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLALRP 193
Cdd:PRK11102 88 LHGLAAAAASVVINALMRDMFPkeefSRMMSFVTLVM----TIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVF 163
|
....*.
gi 15596216 194 W-VPES 198
Cdd:PRK11102 164 FfIPET 169
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
63-191 |
7.09e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 44.68 E-value: 7.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 63 SLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRY 142
Cdd:TIGR00710 47 TLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEE 126
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 15596216 143 RTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLAL 191
Cdd:TIGR00710 127 LSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSAL 175
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
17-191 |
9.54e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.47 E-value: 9.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 17 RTMLIAFVFCFLGLLADGVDLMFLAYSLNSLkaefGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLF 96
Cdd:cd17477 188 RIAPLALLGAFVAGFLEGAFYSLLPLYGLRL----GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 97 SIGTALLGLTQNY-WQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWR 175
Cdd:cd17477 264 ALAALLLPLVPGLpLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPH 343
|
170
....*....|....*.
gi 15596216 176 TLFFTAVAPALVCLAL 191
Cdd:cd17477 344 GLFLFLAAVALLFLLF 359
|
|
| MFS_SLC22A4_5_OCTN1_2 |
cd17376 |
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ... |
63-413 |
9.98e-05 |
|
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340934 [Multi-domain] Cd Length: 342 Bit Score: 44.38 E-value: 9.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 63 SLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRY 142
Cdd:cd17376 42 SLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMGQISNYVVAFVLGTEILGKSV 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 143 R---TTILAAMqaGWTVGYLVATLLAGQIipeFGWRTLFFTAVAPALVCLALRPWVPESpswlaaqagrqrpgaapqsha 219
Cdd:cd17376 122 RilfSTLGVCI--FYAIGYMLLPLFAYFI---RDWRMLLLALTLPGVLCVPLWWFIPIT--------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 220 eaggagplgrmlgdpeTRGMFLLWSLTScfllFGYYGtnnwmpsyleseLGMNFKSMTG--YMVGTYSAMIlgKVAAGVC 297
Cdd:cd17376 176 ----------------TIMSLLLWMAIS----VGYFG------------LSLNTPNLHGdpYLNCFLSAVI--EVPAYII 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 298 ADL----FGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPVG--VLATYMTESFSTRVRGSAVGTAYNL 371
Cdd:cd17376 222 AWLllrsLPRRYSIAATLVLGGGVLLFIQLVPTDLQVLATALVMLGKFGITAAfsMVYVYTAELYPTVVRNMGVGVCSTA 301
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 15596216 372 GRIGAAVAPAGIGLLATHVSIgaGFLVMGITYVLTGLIPALF 413
Cdd:cd17376 302 SRIGSIISPYFVYLGAYDRYL--PYILMGSLTVLIGILTLFL 341
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
82-380 |
1.86e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 43.39 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 82 RFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECvgtrYRTTILAAMQAGWTVGYLVA 161
Cdd:cd17327 67 RFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMW----YKREEQAKRIAFFYAAAGLG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 162 TLLAG------QIIPEF----GWRTLF----FTAVAPALVCLAlrpWVPESPS--W--------LAAQAGRQRPGAAPQS 217
Cdd:cd17327 143 SIFGGllaygvFKILGVgglaGWRWLFiiegLITIIIGLVIFF---WLPDNPSkaWflteeekeLAVERLRANQTGKGDQ 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 218 HAEAGGagpLGRMLGDPETRGMFLLWsltscFLLFG-YYGTNNWMPSYLESELGMNFKSmTGYMVGTYSAMILGKVAAGV 296
Cdd:cd17327 220 KFKWKQ---IKEAFKDPRTWLLFLFF-----FCSQItNNGISNFLPLILKSLGFYSLQT-NLLSVPIGALGAVSLLIAAL 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 297 CADLFGRRLTFAAGA-----IGSAafmpLIVFYHSPSNILWILITFGFIYGVPVGVLATYMTESFST-RVRGSAVGTAYN 370
Cdd:cd17327 291 LSDRFKKRGLFAIFAcvlalVGSI----ILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGyTKRATVLAIMLI 366
|
330
....*....|
gi 15596216 371 LGRIGAAVAP 380
Cdd:cd17327 367 FYNVGNIVAP 376
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
265-419 |
2.06e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 43.26 E-value: 2.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 265 LESELGMNFKSMTGYMVGTYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPsnilWILITFGFIYGVP 344
Cdd:COG0477 40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSP----ELLIAARALQGIG 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596216 345 VGVL----ATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGLIPALFIADRLY 419
Cdd:COG0477 116 AGGLmpgaLALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGL 194
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
47-191 |
2.26e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.33 E-value: 2.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 47 LKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSL 126
Cdd:cd17473 224 LQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLL 303
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15596216 127 FVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLAL 191
Cdd:cd17473 304 LPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAI 368
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
43-413 |
2.31e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 43.38 E-value: 2.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 43 SLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQN--YWQFALIRFVAS 120
Cdd:cd17318 43 TLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARggYGALIVLRILQG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 121 LGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALV-CLALRPWVPesP 199
Cdd:cd17318 123 LAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLwCLLWFFLVL--P 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 200 SW--LAAQAGRQrpgaapqshaeaggagplgrmlgdpetrgmfllwsltscfllFGYYGTNNWMPSYLESELGMNFKSMT 277
Cdd:cd17318 201 VWaiVVAHFGHN------------------------------------------WGFYTLLTELPTYMSDVLHFNIKSNG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 278 GYMVGTYSAMILGKVAAGVCAD----------LFGRRLTFAAGAIGSAAFMPLIVF--YHSPSNILWILITFGFIYGVPV 345
Cdd:cd17318 239 FLSSLPYLAMWICSIVGGYLADwlrsrgilstTTVRKLFTSIGFLGPGVFLIALGYlgSNATLAVVFLTLSVGLSGACYS 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596216 346 GVLATYMteSFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATH-VSIGAGFLVMGIT---YVLTGLIPALF 413
Cdd:cd17318 319 GFLVNHL--DLAPNYAGTLMGITNTAATIAGIISPLIVGAIVKNdQTIGQWRIVFFISaaiYILGAIFYLIF 388
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
52-191 |
2.46e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.93 E-value: 2.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 52 GLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIrFVASLGLGSLFVACN 131
Cdd:cd17478 226 GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTV 304
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 132 ILMSECVGTRYRTTILAAMQAGWTVGYLVATLLaGQIIPEFGWRTLFFTAVAPALVCLAL 191
Cdd:cd17478 305 VLAQELLPGNVGLASGLMMGLSFGLGGIGAPVL-GALADAFGLESVLLILALLPLLGALL 363
|
|
| MFS_SLC22A16_CT2 |
cd17375 |
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ... |
68-409 |
3.58e-04 |
|
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 42.43 E-value: 3.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 68 GMAVGGIYGGWCCDRFGRvRVVTW--TIVLFSIGTALLgLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTT 145
Cdd:cd17375 47 GVLLGAVIFGDIADRIGR-RPVLWftSTGQFVFGIAVA-FTFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKARTW 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 146 ILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLALRP------WVpespSWLAAQAGRQRPGAAPQSha 219
Cdd:cd17375 125 ASMHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLVTIPFILCCWMLPkrtitvWL----IWFTGSLGYYVFSLGSVN-- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 220 eaggagplgrmLGDPETRGMFLLWSLTscfllfgyygtnnwMPSYLESELGMnfksmtgymvgtysamilgkvaagvcaD 299
Cdd:cd17375 199 -----------LGGNEYLNLFLVGAVE--------------IPSYIIACIGM---------------------------D 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 300 LFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITF--GFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAA 377
Cdd:cd17375 227 KLGRRNTLAPFLLLSALACMLIMVIPQDYEVLTIVLSMtgKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSV 306
|
330 340 350
....*....|....*....|....*....|..
gi 15596216 378 VAPAGIGLlaTHVSIGAGFLVMGITYVLTGLI 409
Cdd:cd17375 307 VAPFCVYL--SDVWIFLPQLLVGIMAFLSGIL 336
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
264-414 |
3.81e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 3.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 264 YLESELGMNFkSMTGYMVGTYS-AMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYG 342
Cdd:cd17329 25 YLHQQLGLSA-SIVGLVLALSAvAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGG 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596216 343 VPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHvSIGAGFLVMGITYVLTGLIPALFI 414
Cdd:cd17329 104 LFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLL 174
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
16-187 |
4.29e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 4.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 16 RRTMLIAFVFCFLGLLADGVDLMFLAYslnsLKAEFGLSNFEAGSLGSLT-LAGMAVGGIYGGWCCDRFGRVRVVTWTIV 94
Cdd:cd17330 174 PPLRRLLLVYFLIALAFAGLESVFSLF----LKDRFGFSPSQIGLLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 95 LFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGW 174
Cdd:cd17330 250 LAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGP 329
|
170
....*....|...
gi 15596216 175 RTLFFTAVAPALV 187
Cdd:cd17330 330 GVPFLLAAGLLLI 342
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
23-191 |
5.06e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 42.21 E-value: 5.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 23 FVFCFLGLLADGVDLMFLAYSLNSLkaefGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTAL 102
Cdd:cd17390 2 YLVGFLDLFGVSMILPLLSTHIRSL----GASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 103 LGLTQNYWQFALIRFVASLGLGSLFVaCNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIP-EFGWRTLFFTA 181
Cdd:cd17390 78 LGFSTSLALLFLSRIPLGIFKHTQSL-CKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAEtDGGFYYVALLC 156
|
170
....*....|
gi 15596216 182 VAPALVCLAL 191
Cdd:cd17390 157 SAIFILNAGL 166
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
38-170 |
5.40e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.13 E-value: 5.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 38 MFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSI----GTALLGLTQNYWQFA 113
Cdd:cd17369 246 LFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALfafpFFWLLDTGSTWLIVL 325
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 15596216 114 LIRFVASLGLGSLFVACNILMSECVGTRYRTTilaamqaGWTVGYLVATLLAGQIIP 170
Cdd:cd17369 326 AAVVVLGVLHGMMYGPQAAFLAELFPTRVRYT-------GASLGYQLGAILGGGFAP 375
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
53-210 |
1.07e-03 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 41.36 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 53 LSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNI 132
Cdd:cd17434 38 LNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPV 117
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596216 133 LMSECVGTRYRTTILAAMQAGWTVGYLVATLLaGQIIPefgWRTLFFTAVAPALVCLALRPWVPESPSWLAAQAGRQR 210
Cdd:cd17434 118 YVSEISHPGVRGALGACPQIMAVFGSLALYAL-GLLLP---WRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEK 191
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
47-191 |
1.33e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 40.67 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 47 LKAEFGLSNFEAGSLGSLT-LAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGS 125
Cdd:cd17331 234 AMDFFGLTPEENGYLMSYAgVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSV 313
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596216 126 LFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLAL 191
Cdd:cd17331 314 LYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVY 379
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
287-441 |
1.87e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 40.30 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 287 MILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPVGVLATYMTESFSTRVRGSAVG 366
Cdd:cd17475 44 VAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMG 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596216 367 ---TAYNLGrigAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGLIPALFiadrLYDPNRESRDAESASRRQAPGSAV 441
Cdd:cd17475 124 irqTGVPLG---GALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLF----YREPPAASAATESASTLLRSLKEV 194
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
156-414 |
2.22e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.28 E-value: 2.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 156 VGYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLALRPWVPEspswlaaqagrQRPGAAPQSHAEAGgagpLGRMLGDPe 235
Cdd:cd17490 131 LGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKE-----------ERREKKPVLTELKE----LLSVLKDK- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 236 trgMFLLWSLTSCFLLFGYYGTNNWMPSYLESELGMNfKSMTGYMVGTYsaMILGKVAAGVCADLFGRRL----TFAAGA 311
Cdd:cd17490 195 ---KLLFFSLLAILQQMITFSTTFGFTPLIAKQLGAS-SFQLGLLSIIY--LLPNALASLLSGTLFYKKLgernTIIIGF 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 312 IGSAAFMPLIVFYHSPSNILWILITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVS 391
Cdd:cd17490 269 LLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG 348
|
250 260
....*....|....*....|...
gi 15596216 392 IGAGFLVMGITYVLTGLIPALFI 414
Cdd:cd17490 349 LQTGFFVIGVIALLAAILSLAYY 371
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
77-213 |
3.43e-03 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 39.48 E-value: 3.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 77 GWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTV 156
Cdd:PRK05122 270 GNLINRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALIGAALTGFGFSLVFPALGVEAVKRVPPQNRGAALGAYSVFLDL 349
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 15596216 157 GYLVATLLAGQIIPEFGWRTLFFTAVAPALVCLALrpwvpesPSWLAAQAGRQRPGA 213
Cdd:PRK05122 350 SLGITGPLAGLVASWFGYPSIFLAAALAALLGLAL-------TWLLYRRAPRAVPEA 399
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
22-191 |
3.77e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.56 E-value: 3.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 22 AFVFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIGTA 101
Cdd:cd17355 211 SFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLA 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 102 LLGLTQNYWQFALIrFVASLGLGSLFVA--CNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFG-WRTLF 178
Cdd:cd17355 291 LLLLLPFPPLALLL-FAALFGLGWGATVplTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAW 369
|
170
....*....|...
gi 15596216 179 FTAVAPALVCLAL 191
Cdd:cd17355 370 ALAVALGLIAALL 382
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
20-379 |
3.83e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 39.32 E-value: 3.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 20 LIAFVFCFLGLLADGVDLMFLAYSLNSLKAeFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSIG 99
Cdd:cd17314 3 FVLYVSFLLSAMSTGFILSWSLFYQPWQDA-FGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 100 TALLGLTQNYWqFALIRFVASLGLGslfvaCNILMSECVGTRYRTTI------LAAMQAGWTVGYLVATLLAGQIIPEFG 173
Cdd:cd17314 82 YTYLSYVFNSF-PLSYACFVFIGAG-----TGILYGSAVLVTTQYFPdtkglaLGLPTTGYSLGLVLGSPLLRILWVFYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 174 WRTLFFTAVAPALVCLALrpwvpespswLAAQAGRQRPGAAPQSHAEAGGAGPLGRMLGDPETRGMFLLW--SLTSCFLL 251
Cdd:cd17314 156 LALVYTILGILAAIVLSV----------VSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIflVLIGGFLF 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 252 FGYYGTNNWMPSYLESELGMNFKSMTGYMVGtysamiLGKVAAGVCADLFGRRLTFAAGAIGSAAFMpLIVFYHSPSNIL 331
Cdd:cd17314 226 IANMASLVRSLQLDAPSFVTKLMSIYGLFNA------FGRLLWGIVADFFGGRLSTLSILLTILGLG-LCAFLFLLKMTP 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 15596216 332 WILITFGFIYGVPVGVLATYMTESFSTRVRGSAVGTAYNLGRIGAAVA 379
Cdd:cd17314 299 VGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIG 346
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
275-432 |
3.95e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.33 E-value: 3.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 275 SMTGYMVGTYS-AMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPVGVLATYMT 353
Cdd:cd06174 31 SQLGLLFALFSlGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 354 ESFSTRVRGSAVGtaynLGR----IGAAVAPAGIGLLATHVSIG--AGFLVMGITYVLTGLIPALFIADRLYDPNRESRD 427
Cdd:cd06174 111 DLFPERERGRALG----LLQafgsVGGILGPLLGGILASSLGFGwrAVFLIAAALALLAAILLLLVVPDPPESARAKNEE 186
|
....*
gi 15596216 428 AESAS 432
Cdd:cd06174 187 ASSKS 191
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
47-204 |
5.39e-03 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 38.92 E-value: 5.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 47 LKAEFGLSNFEAGSL-GSLTLAGMaVGGIYGGWCCDRFGRvrvvTWTIVL----FSIGTALLGLTQNYWQFALIRFVASL 121
Cdd:cd17437 23 IKEDLKISDVQEEVLiGSLNIISL-VGSLAAGRTSDWIGR----RYTIALaaliFFVGALLMGVAPNYPVLMVGRFVAGI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 122 GLGSLFVACNILMSECVGTRYRTTILA----AMQAGWTVGYLVATLLAGqIIPEFGWRTLFFTAVAPALVCLALRPWVPE 197
Cdd:cd17437 98 GVGFALMIAPVYTAEVAPASSRGFLTSfpeiFINIGILLGYVSNYAFSG-LPLHVGWRLMLGVGAVPSLFLAIGVLAMPE 176
|
....*..
gi 15596216 198 SPSWLAA 204
Cdd:cd17437 177 SPRWTPA 183
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
24-191 |
6.99e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 6.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 24 VFCFLGLLADGVDLMFLAYSLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWC-CDRFGRVRVVTWTIVLFSIGTAL 102
Cdd:cd17490 198 FFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLfYKKLGERNTIIIGFLLLGAYCFL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 103 LGLTQNYWQFALIRFVASLGLGSLFVACNILMSECVGTRYRTTILAAMQAGWTVGYLVATLLAGQIIPEFGWRTLFFTAV 182
Cdd:cd17490 278 IPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIG 357
|
....*....
gi 15596216 183 APALVCLAL 191
Cdd:cd17490 358 VIALLAAIL 366
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
61-202 |
7.33e-03 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 38.75 E-value: 7.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 61 LGSLTLAGMAVGGIYG----GWCCDRFGRVRVVTWTIVLFSIGTALLGLTQNYWQFALI---RFVASLGLGslfVACNIL 133
Cdd:cd17432 51 LWSLTVSIFPLGGLFGsllvGPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAKSFEMIivgRFLVGINAG---ISLNVV 127
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596216 134 ---MSECVGTRYRTTILAAMQAGWTVGYLVATLLAgqiIPEF-----GWRTLFFTAVAPALVCLALRPWVPESPSWL 202
Cdd:cd17432 128 pmyLGESAPKNLRGAVGLVPAIFITLGILLGQVLG---LRELlgneeGWPLLLALTGVPALLQLLTLPFFPESPRYL 201
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
263-415 |
7.83e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.35 E-value: 7.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 263 SYLESELGMNFKSMTGYMVG--TYSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFyhSPSniLWILITFGFI 340
Cdd:cd17316 23 PVLAAEFSLGLSLLQTGLLFaaGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGL--LPT--PILLLVLRFL 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596216 341 YGVPVG----VLATYMTESFSTRVRGSAVGTAYNLGRIGAAVAPAGIGLLATHVSIGAGFLVMgityVLTGLIPALFIA 415
Cdd:cd17316 99 QGIGIGgeypGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRIL----FLIGALPALLAL 173
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
284-417 |
9.63e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 38.02 E-value: 9.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 284 YSAMILGKVAAGVCADLFGRRLTFAAGAIGSAAFMPLIVFYHSPSNILWILITFGFIYGVPVGVLATYMTESFSTRVRGS 363
Cdd:cd17312 48 LIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGT 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 15596216 364 AVG---TAYNlgrIGAAVAPAGIGLLATHVSIGAGFLVMGITYVLTGLIPALFIADR 417
Cdd:cd17312 128 VYGiwsTSHN---FGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDS 181
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
22-164 |
9.97e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 37.99 E-value: 9.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 22 AFVFCFLGLLAdgvdLMFLAY---SLNSLKAEFGLSNFEAGSLGSLTLAGMAVGGIYGGWCCDRFGRVRVVTWTIVLFSI 98
Cdd:cd17336 5 VVLLCLLGLLQ----GAVVSYfvsTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596216 99 GTALLGLTQnywQFALIRFVASLGLGSLFVACNILMSECVGTR----YRTTILAAMQAGWTVGYLVATLL 164
Cdd:cd17336 81 GCFLLALPH---FLFVGQFLLGIGSSPLYTLGITYIDDNVSKKnsplYIGILYAMRVLGPALGFLLGSFL 147
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| |
