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Conserved domains on  [gi|15596321|ref|NP_249815|]
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deoxyguanosinetriphosphate triphosphohydrolase [Pseudomonas aeruginosa PAO1]

Protein Classification

deoxyguanosinetriphosphate triphosphohydrolase( domain architecture ID 11480315)

deoxyguanosinetriphosphate (dGTP) triphosphohydrolase catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
dgt PRK04926
deoxyguanosinetriphosphate triphosphohydrolase; Provisional
2-498 0e+00

deoxyguanosinetriphosphate triphosphohydrolase; Provisional


:

Pssm-ID: 235320 [Multi-domain]  Cd Length: 503  Bit Score: 781.80  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321    2 PGAVDFKERISRQRPHDREtyghAGNTDLQDIVYQLESDRGRIVNSAAVRRLQQKTQVFPLERNAAVRSRLTHSLEVQQT 81
Cdd:PRK04926   1 MAMIDFRKKINWQRRYRSP----QGVKTEHEILRIFESDRGRIINSAAIRRLQQKTQVFPLERNAAVRSRLTHSLEVQQV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   82 GRFIVRTLFRQLGPRA--AEVGLDGLEGALESLVEMACLMHDVGNPPFGHFGEYAINDWFERNLDALF------------ 147
Cdd:PRK04926  77 GRYIAKEILSRLKEQKllEAYGLDELTGPFESIVEMACLMHDIGNPPFGHFGEAAINDWFRQRLDPDAesqpltddrcsv 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  148 -ERRIPPGQ-GDGLLQQRMLTDLKHFEGNAQAIRLVVKLLRLNLTYTQTAGLLKYVRPAYEPKPDkAAANHYLNKKPGFY 225
Cdd:PRK04926 157 aALRLRDGEePLNELRRKIRQDLCHFEGNAQGIRLVHTLLRLNLTYAQVACILKYTRPAWWRGPT-PASHHYLMKKPGYY 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  226 LSEEAFVDELRRVLGMRPGTRHPVAYIMEAADDISYCLADIEDSVEKGILDIRQLADLLVKKFAVHHSPDapipgdadnm 305
Cdd:PRK04926 236 LSEEAYVARLRKELNLAPYSRFPLTYIMEAADDISYCIADLEDAVEKRIFSVEQLYHHLHEAWGEHEKGD---------- 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  306 SFQRMVDYSLEKAEREPINKVSE--FFIRLRVKMIHPLVQHAAQQFIDNFEAVHAGTLGRALMEDGSLPHAIVQTFKDVA 383
Cdd:PRK04926 306 LFSLVVENAWEKSRANSLSRSSEdqFFMYLRVNTLNKLVPYAAQRFIDNLPAIFAGTFNQALLEDASPASRLLKTFKNVA 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  384 MEWVFCHPEVETLELQGYRIIQGLLDFYAPLLRLPAEEFQALAEGRQ-AAAPHPQLLVRRLPSQQIKAYLEAMKGVAEDP 462
Cdd:PRK04926 386 RKHVFSHPEVEQLELQGYRVISGLLDIYSPLLALPLEDFTELVEKERhKRYPIETRLFHKLSTRHRLAYVEAVSKLPSDS 465
                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 15596321  463 L-QRQWEFYHRCRMLQDFVSGMTDQHAQDEYRALSAL 498
Cdd:PRK04926 466 PeFPLWEYYYRARLIQDYISGMTDLYAWDEYRRLMAV 502
 
Name Accession Description Interval E-value
dgt PRK04926
deoxyguanosinetriphosphate triphosphohydrolase; Provisional
2-498 0e+00

deoxyguanosinetriphosphate triphosphohydrolase; Provisional


Pssm-ID: 235320 [Multi-domain]  Cd Length: 503  Bit Score: 781.80  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321    2 PGAVDFKERISRQRPHDREtyghAGNTDLQDIVYQLESDRGRIVNSAAVRRLQQKTQVFPLERNAAVRSRLTHSLEVQQT 81
Cdd:PRK04926   1 MAMIDFRKKINWQRRYRSP----QGVKTEHEILRIFESDRGRIINSAAIRRLQQKTQVFPLERNAAVRSRLTHSLEVQQV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   82 GRFIVRTLFRQLGPRA--AEVGLDGLEGALESLVEMACLMHDVGNPPFGHFGEYAINDWFERNLDALF------------ 147
Cdd:PRK04926  77 GRYIAKEILSRLKEQKllEAYGLDELTGPFESIVEMACLMHDIGNPPFGHFGEAAINDWFRQRLDPDAesqpltddrcsv 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  148 -ERRIPPGQ-GDGLLQQRMLTDLKHFEGNAQAIRLVVKLLRLNLTYTQTAGLLKYVRPAYEPKPDkAAANHYLNKKPGFY 225
Cdd:PRK04926 157 aALRLRDGEePLNELRRKIRQDLCHFEGNAQGIRLVHTLLRLNLTYAQVACILKYTRPAWWRGPT-PASHHYLMKKPGYY 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  226 LSEEAFVDELRRVLGMRPGTRHPVAYIMEAADDISYCLADIEDSVEKGILDIRQLADLLVKKFAVHHSPDapipgdadnm 305
Cdd:PRK04926 236 LSEEAYVARLRKELNLAPYSRFPLTYIMEAADDISYCIADLEDAVEKRIFSVEQLYHHLHEAWGEHEKGD---------- 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  306 SFQRMVDYSLEKAEREPINKVSE--FFIRLRVKMIHPLVQHAAQQFIDNFEAVHAGTLGRALMEDGSLPHAIVQTFKDVA 383
Cdd:PRK04926 306 LFSLVVENAWEKSRANSLSRSSEdqFFMYLRVNTLNKLVPYAAQRFIDNLPAIFAGTFNQALLEDASPASRLLKTFKNVA 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  384 MEWVFCHPEVETLELQGYRIIQGLLDFYAPLLRLPAEEFQALAEGRQ-AAAPHPQLLVRRLPSQQIKAYLEAMKGVAEDP 462
Cdd:PRK04926 386 RKHVFSHPEVEQLELQGYRVISGLLDIYSPLLALPLEDFTELVEKERhKRYPIETRLFHKLSTRHRLAYVEAVSKLPSDS 465
                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 15596321  463 L-QRQWEFYHRCRMLQDFVSGMTDQHAQDEYRALSAL 498
Cdd:PRK04926 466 PeFPLWEYYYRARLIQDYISGMTDLYAWDEYRRLMAV 502
Dgt COG0232
dGTP triphosphohydrolase [Nucleotide transport and metabolism];
38-496 3.16e-110

dGTP triphosphohydrolase [Nucleotide transport and metabolism];


Pssm-ID: 440002 [Multi-domain]  Cd Length: 345  Bit Score: 330.58  E-value: 3.16e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  38 ESDRGRIVNSAAVRRLQQKTQVFPLERNAAVRSRLTHSLEVQQTGRFIVRTLfrqlgpraaevgldgleGALESLVEMAC 117
Cdd:COG0232   8 QRDRDRIIHSAAFRRLQDKTQVFPLPEGDHYRTRLTHSLEVAQIARSIARAL-----------------GLNEDLVEAAA 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321 118 LMHDVGNPPFGHFGEYAINDWFErnldalferrippgqgdgllqqrmltDLKHFEGNAQAIRLVVKLLR------LNLTY 191
Cdd:COG0232  71 LAHDLGHPPFGHAGEDALNELFR--------------------------DLGGFEGNAQSLRILTRLEKryafggLNLTY 124
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321 192 TQTAGLLKYVRPAYEPKPDkaaanhylnKKPGFYLSEEAFVDELRRVLGMRPGT--RHPVAYIMEAADDISYCLADIEDS 269
Cdd:COG0232 125 ATLDGILKYPGPSLAAPKP---------KPKGFYQSEKDVFDWVREELGLLALGrpRTLEAQIVELADDIAYSVHDLEDA 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321 270 VEKGILDIRQLADLLVKkfavhhspdapipgdadnmsfqrmvDYSLEKaerepinkvSEFFIRLRVKMIHPLVQHAAQQF 349
Cdd:COG0232 196 IRAGLLSLEDLPELLEY-------------------------LGPLDE---------RRRLGELRSRLIGRLVTDVIEAS 241
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321 350 IDNFeavhagtLGRALMEDGSLPHAIVQTFKDVAMEWVFCHPEVETLELQGYRIIQGLLDFYApllrlpaeefqalaegr 429
Cdd:COG0232 242 RENL-------FDGPLIAFSPEVAAALKELKKFLFERVYRHPEVLRLELKGRRIIRELFDAFL----------------- 297
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596321 430 qaaaphpQLLVRRLPSQQIKAYleamkgvaedplQRQWEFYHRCRMLQDFVSGMTDQHAQDEYRALS 496
Cdd:COG0232 298 -------EDPLELLPEEFRERY------------EAADDEYGRLRVVADYIAGMTDRYALRLYRRLF 345
dGTP_triPase TIGR01353
deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) ...
36-495 1.15e-106

deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273571 [Multi-domain]  Cd Length: 381  Bit Score: 322.78  E-value: 1.15e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321    36 QLESDRGRIVNSAAVRRLQQKTQVFPLERNAAVRSRLTHSLEVQQTGRFIVRTLFRQLGPRAAEVGLDglegalESLVEM 115
Cdd:TIGR01353   4 PFERDYDRIIHSSAFRRLQDKTQVFPLAENDFVRTRLTHSLEVAQVGRSIANLIGLRYDLELEELGPF------ERLAET 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   116 ACLMHDVGNPPFGHFGEYAINDWFERNldalferrippgqgdgllqqrmltdLKHFEGNAQAIRLVVKLLR-------LN 188
Cdd:TIGR01353  78 ACLAHDIGNPPFGHAGERALNDWMREY-------------------------GPGFEGNAQTFRILTTLEKrrrakggLN 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   189 LTYTQTAGLLKYVRPAYEpkpdKAAANHYLNKKPGFYLSEEAFVDELRRVLGMRpGTRHPVAYIMEAADDISYCLADIED 268
Cdd:TIGR01353 133 LTWRTLAGILKYPRPSSE----DAFKGGYLNKKKGIYDSELAVFDRVAELLGLT-WYRSPLAQLMEAADDIAYTVHDLED 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   269 SVEKGILDIRQLADLLvkkfavhhspdAPIPGDADNMSfqRMVDyslekaerEPINKVSEFFIRLRVKMIHPLVQHAAQ- 347
Cdd:TIGR01353 208 AIKLGLLTFDDLQHLL-----------LIQAGFEELGS--EMTD--------LSISAENEQIRSLRGKLITDLIESVAKa 266
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   348 QFIDNFEAVHAGTLGRALMEDGSLPHAIVQTFKDVAMEWVFCHPEVETLELQGYRIIQGLLDFYAPLLRlpaeefqalae 427
Cdd:TIGR01353 267 EFSSHLVAILIGTFHHTLVEFSPRLAELLEALKKFLRKRVYRHPDVERIEYQGEQIITGLFDAFMPDLP----------- 335
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596321   428 grqaAAPHPQLLVRRLPSqqikayleamkgvaedplqrQWEFYHRCRMLQDFVSGMTDQHAQDEYRAL 495
Cdd:TIGR01353 336 ----PRLLPPELRSKLRK--------------------AEDNYYKARVVCDYIAGMTDRYALEEYRRL 379
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
67-140 5.83e-04

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 39.97  E-value: 5.83e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596321     67 AVRSRLTHSLEVQQTGRFIvrtlfrqlgprAAEVGLDGLEgalesLVEMACLMHDVGNPPFGHFGEYAINDWFE 140
Cdd:smart00471   1 SDYHVFEHSLRVAQLAAAL-----------AEELGLLDIE-----LLLLAALLHDIGKPGTPDSFLVKTSVLED 58
HD pfam01966
HD domain; HD domains are metal dependent phosphohydrolases.
71-129 4.36e-03

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 460398 [Multi-domain]  Cd Length: 110  Bit Score: 36.83  E-value: 4.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15596321    71 RLTHSLEVQQtgrfIVRTLFRQLGPRAAEvgldglegalesLVEMACLMHDVGNPPFGH 129
Cdd:pfam01966   1 RLEHSLRVAL----LARELAEELGELDRE------------LLLLAALLHDIGKGPFGD 43
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
69-135 6.76e-03

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 37.32  E-value: 6.76e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596321  69 RSRLTHSLEVQQTGRFIVRTLfrqlgpraaevgldGLEGALESLVEMACLMHDVGNPPFGHFGEYAI 135
Cdd:cd00077   1 EHRFEHSLRVAQLARRLAEEL--------------GLSEEDIELLRLAALLHDIGKPGTPDAITEEE 53
 
Name Accession Description Interval E-value
dgt PRK04926
deoxyguanosinetriphosphate triphosphohydrolase; Provisional
2-498 0e+00

deoxyguanosinetriphosphate triphosphohydrolase; Provisional


Pssm-ID: 235320 [Multi-domain]  Cd Length: 503  Bit Score: 781.80  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321    2 PGAVDFKERISRQRPHDREtyghAGNTDLQDIVYQLESDRGRIVNSAAVRRLQQKTQVFPLERNAAVRSRLTHSLEVQQT 81
Cdd:PRK04926   1 MAMIDFRKKINWQRRYRSP----QGVKTEHEILRIFESDRGRIINSAAIRRLQQKTQVFPLERNAAVRSRLTHSLEVQQV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   82 GRFIVRTLFRQLGPRA--AEVGLDGLEGALESLVEMACLMHDVGNPPFGHFGEYAINDWFERNLDALF------------ 147
Cdd:PRK04926  77 GRYIAKEILSRLKEQKllEAYGLDELTGPFESIVEMACLMHDIGNPPFGHFGEAAINDWFRQRLDPDAesqpltddrcsv 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  148 -ERRIPPGQ-GDGLLQQRMLTDLKHFEGNAQAIRLVVKLLRLNLTYTQTAGLLKYVRPAYEPKPDkAAANHYLNKKPGFY 225
Cdd:PRK04926 157 aALRLRDGEePLNELRRKIRQDLCHFEGNAQGIRLVHTLLRLNLTYAQVACILKYTRPAWWRGPT-PASHHYLMKKPGYY 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  226 LSEEAFVDELRRVLGMRPGTRHPVAYIMEAADDISYCLADIEDSVEKGILDIRQLADLLVKKFAVHHSPDapipgdadnm 305
Cdd:PRK04926 236 LSEEAYVARLRKELNLAPYSRFPLTYIMEAADDISYCIADLEDAVEKRIFSVEQLYHHLHEAWGEHEKGD---------- 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  306 SFQRMVDYSLEKAEREPINKVSE--FFIRLRVKMIHPLVQHAAQQFIDNFEAVHAGTLGRALMEDGSLPHAIVQTFKDVA 383
Cdd:PRK04926 306 LFSLVVENAWEKSRANSLSRSSEdqFFMYLRVNTLNKLVPYAAQRFIDNLPAIFAGTFNQALLEDASPASRLLKTFKNVA 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  384 MEWVFCHPEVETLELQGYRIIQGLLDFYAPLLRLPAEEFQALAEGRQ-AAAPHPQLLVRRLPSQQIKAYLEAMKGVAEDP 462
Cdd:PRK04926 386 RKHVFSHPEVEQLELQGYRVISGLLDIYSPLLALPLEDFTELVEKERhKRYPIETRLFHKLSTRHRLAYVEAVSKLPSDS 465
                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 15596321  463 L-QRQWEFYHRCRMLQDFVSGMTDQHAQDEYRALSAL 498
Cdd:PRK04926 466 PeFPLWEYYYRARLIQDYISGMTDLYAWDEYRRLMAV 502
Dgt COG0232
dGTP triphosphohydrolase [Nucleotide transport and metabolism];
38-496 3.16e-110

dGTP triphosphohydrolase [Nucleotide transport and metabolism];


Pssm-ID: 440002 [Multi-domain]  Cd Length: 345  Bit Score: 330.58  E-value: 3.16e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  38 ESDRGRIVNSAAVRRLQQKTQVFPLERNAAVRSRLTHSLEVQQTGRFIVRTLfrqlgpraaevgldgleGALESLVEMAC 117
Cdd:COG0232   8 QRDRDRIIHSAAFRRLQDKTQVFPLPEGDHYRTRLTHSLEVAQIARSIARAL-----------------GLNEDLVEAAA 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321 118 LMHDVGNPPFGHFGEYAINDWFErnldalferrippgqgdgllqqrmltDLKHFEGNAQAIRLVVKLLR------LNLTY 191
Cdd:COG0232  71 LAHDLGHPPFGHAGEDALNELFR--------------------------DLGGFEGNAQSLRILTRLEKryafggLNLTY 124
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321 192 TQTAGLLKYVRPAYEPKPDkaaanhylnKKPGFYLSEEAFVDELRRVLGMRPGT--RHPVAYIMEAADDISYCLADIEDS 269
Cdd:COG0232 125 ATLDGILKYPGPSLAAPKP---------KPKGFYQSEKDVFDWVREELGLLALGrpRTLEAQIVELADDIAYSVHDLEDA 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321 270 VEKGILDIRQLADLLVKkfavhhspdapipgdadnmsfqrmvDYSLEKaerepinkvSEFFIRLRVKMIHPLVQHAAQQF 349
Cdd:COG0232 196 IRAGLLSLEDLPELLEY-------------------------LGPLDE---------RRRLGELRSRLIGRLVTDVIEAS 241
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321 350 IDNFeavhagtLGRALMEDGSLPHAIVQTFKDVAMEWVFCHPEVETLELQGYRIIQGLLDFYApllrlpaeefqalaegr 429
Cdd:COG0232 242 RENL-------FDGPLIAFSPEVAAALKELKKFLFERVYRHPEVLRLELKGRRIIRELFDAFL----------------- 297
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596321 430 qaaaphpQLLVRRLPSQQIKAYleamkgvaedplQRQWEFYHRCRMLQDFVSGMTDQHAQDEYRALS 496
Cdd:COG0232 298 -------EDPLELLPEEFRERY------------EAADDEYGRLRVVADYIAGMTDRYALRLYRRLF 345
dGTP_triPase TIGR01353
deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) ...
36-495 1.15e-106

deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273571 [Multi-domain]  Cd Length: 381  Bit Score: 322.78  E-value: 1.15e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321    36 QLESDRGRIVNSAAVRRLQQKTQVFPLERNAAVRSRLTHSLEVQQTGRFIVRTLFRQLGPRAAEVGLDglegalESLVEM 115
Cdd:TIGR01353   4 PFERDYDRIIHSSAFRRLQDKTQVFPLAENDFVRTRLTHSLEVAQVGRSIANLIGLRYDLELEELGPF------ERLAET 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   116 ACLMHDVGNPPFGHFGEYAINDWFERNldalferrippgqgdgllqqrmltdLKHFEGNAQAIRLVVKLLR-------LN 188
Cdd:TIGR01353  78 ACLAHDIGNPPFGHAGERALNDWMREY-------------------------GPGFEGNAQTFRILTTLEKrrrakggLN 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   189 LTYTQTAGLLKYVRPAYEpkpdKAAANHYLNKKPGFYLSEEAFVDELRRVLGMRpGTRHPVAYIMEAADDISYCLADIED 268
Cdd:TIGR01353 133 LTWRTLAGILKYPRPSSE----DAFKGGYLNKKKGIYDSELAVFDRVAELLGLT-WYRSPLAQLMEAADDIAYTVHDLED 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   269 SVEKGILDIRQLADLLvkkfavhhspdAPIPGDADNMSfqRMVDyslekaerEPINKVSEFFIRLRVKMIHPLVQHAAQ- 347
Cdd:TIGR01353 208 AIKLGLLTFDDLQHLL-----------LIQAGFEELGS--EMTD--------LSISAENEQIRSLRGKLITDLIESVAKa 266
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   348 QFIDNFEAVHAGTLGRALMEDGSLPHAIVQTFKDVAMEWVFCHPEVETLELQGYRIIQGLLDFYAPLLRlpaeefqalae 427
Cdd:TIGR01353 267 EFSSHLVAILIGTFHHTLVEFSPRLAELLEALKKFLRKRVYRHPDVERIEYQGEQIITGLFDAFMPDLP----------- 335
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596321   428 grqaAAPHPQLLVRRLPSqqikayleamkgvaedplqrQWEFYHRCRMLQDFVSGMTDQHAQDEYRAL 495
Cdd:TIGR01353 336 ----PRLLPPELRSKLRK--------------------AEDNYYKARVVCDYIAGMTDRYALEEYRRL 379
PRK01096 PRK01096
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
38-496 1.32e-94

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 234897 [Multi-domain]  Cd Length: 440  Bit Score: 293.75  E-value: 1.32e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   38 ESDRGRIVNSAAVRRLQQKTQVFPLERNAAVRSRLTHSLEVQQTGrfivrtlfRQLGPRAAEVGLDGLE------GALES 111
Cdd:PRK01096  29 HKDYDRIIFSGSFRRLQRKTQVHPLAKNDHIHTRLTHSLEVSCVG--------RSLGMRVGETLKEEKLpdwispADIGA 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  112 LVEMACLMHDVGNPPFGHFGEYAINDWFERNLDALFERRIPPgqgdgllqqRMLTDLKHFEGNAQAIRLVVKLLRL---- 187
Cdd:PRK01096 101 IVQSACLAHDIGNPPFGHFGEDAIREWFQDAAGRGFLDDLSP---------QERADFLNFEGNAQGFRVLTKLEYHqddg 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  188 --NLTYTQTAGLLKYvrPAYEPKPDKAAanhYLNKKPGFYLSEEAFVDELRRVLGMRPGT-----RHPVAYIMEAADDIS 260
Cdd:PRK01096 172 gmRLTYATLGTYIKY--PWSSRHANKQQ---IKKKKFGCYQSELPLFEQIAEALGLPQLGeqrwcRHPLTYLLEAADDIC 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  261 YCLADIEDSVEKGILDIRQLADLLVkkfavhhspdaPIPGDADnmsfqRMVDYSLEKAEREPINkvseffiRLRVKMIHP 340
Cdd:PRK01096 247 YALIDLEDGLEMGLLNYQEVEALFL-----------ELIGDKE-----KYRQLGPQDSRRQKLA-------RLRGKAIGR 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  341 LVQHAAQQFIDNFEAVHAGTLGRALME--DGSLpHAIVQTFKDVAMEWVFCHPEVETLELQGYRIIQGLLDFYAPllrlp 418
Cdd:PRK01096 304 LVNAVAEAFVENYDAILAGTLPGDLIEhcDPDA-KRCVQQAKDLAREKIFQHKRKVELEIGAYTILEILLDAFVP----- 377
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596321  419 aeefqalaegrqaaAPHPQLLVRRLPSQQiKAYLEAMKGVAEDPlqrQWEFYHRCRMLQDFVSGMTDQHAQDEYRALS 496
Cdd:PRK01096 378 --------------AALYYDSGTTPSFKD-KRLLDLLGDNAPDP---TMKLYLRLLRVLDFISGMTDSYAKELAQELT 437
PRK05318 PRK05318
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
17-495 4.93e-44

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 235403 [Multi-domain]  Cd Length: 432  Bit Score: 160.81  E-value: 4.93e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   17 HDRETYGHAGNTDLQDIVYQleSDRGRIVNSAAVRRLQQKTQVFPLERNAAVRSRLTHSLEVQQTGRFIVRTLFRQLGPR 96
Cdd:PRK05318   7 QERRLGEDKQRRNDHRSPYQ--RDRARILHSAAFRRLQAKTQVLGVGENDFYRTRLTHSLEVAQIGTGIVAQLKKEKQPE 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   97 aaevgldgLEGALES--LVEMACLMHDVGNPPFGHFGEYAINdwfernldalferrippgqgdgllqqRMLTDLKHFEGN 174
Cdd:PRK05318  85 --------LKPLLPSdsLIESLCLAHDIGHPPFGHGGEVALN--------------------------YMMRDHGGFEGN 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  175 AQAIRLVVKL------LRLNLTYTQTAGLLKYvrPA-----YEPKPDKAAANHYLNK----KP--GFYLSEEAFVDEL-- 235
Cdd:PRK05318 131 GQTFRILTKLepytehFGMNLTRRTLLGILKY--PAlyselVAQYPPPDVANHRQLKasdwKPpkGIFDDDQDIFDWVle 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  236 ------------RRVLGMRPGTRHPVAY------IMEAADDISYCLADIEDSVEKGILDIRQLADLLVKKFAvhHSPDAP 297
Cdd:PRK05318 209 plsendralfqsLRPEPDSPKEHLKTRYksldcsIMELADDIAYGVHDLEDAIVLGLVTRSQWQEDVAPQLA--QCGDPW 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  298 IPGDADNMSfQRMvdYSLEKAER-EPINK-VSEFFIRLRVKMI----HPLVQHAAqQFIDNFEAVhagtlgralmedgsl 371
Cdd:PRK05318 287 LEEEIETIG-EKL--FSGEHHLRkDAIGTlVNYFITSIRIKENeefeEPLLRYNA-ALEPEFAAA--------------- 347
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  372 phaiVQTFKDVAMEWVFCHPEVETLELQGYRIIQGLldfyapllrlpaeeFQALAEGrqaaaphPQllvRRLPSQQIKAY 451
Cdd:PRK05318 348 ----LEVLKQFVYKYVIRKPEVQRLEYKGQQIVMEL--------------FEALSSD-------PE---RLLPRNTQERW 399
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 15596321  452 LEamkgvAEDPLQRQwefyhrcRMLQDFVSGMTDQHAQDEYRAL 495
Cdd:PRK05318 400 RK-----AEDEENSM-------RVICDYISGMTDEYAYRLYQQL 431
PRK03007 PRK03007
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
40-283 2.71e-34

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 235098 [Multi-domain]  Cd Length: 428  Bit Score: 133.53  E-value: 2.71e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   40 DRGRIVNSAAVRRLQQKTQVF-PLERNAAvRSRLTHSLEVQQTGRFIvrtlfrqlgprAAEVGLDglegalESLVEMACL 118
Cdd:PRK03007  40 DRARVLHSAALRRLADKTQVVgPREGDTP-RTRLTHSLEVAQIGRGI-----------AAGLGCD------PDLVDLAGL 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  119 MHDVGNPPFGHFGEYAINDWfernldalferrippgqgdgllqqrmLTDLKHFEGNAQAIRLVVKL-----------LRL 187
Cdd:PRK03007 102 AHDIGHPPYGHNGERALDEV--------------------------AADCGGFEGNAQTLRILTRLepkvldpdgrsAGL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  188 NLTYTQTAGLLKYVRPAYEPKPDKaaanhylNKKPGFYLSEEAFVDELRRvlgMRPGTRHPV-AYIMEAADDISYCLADI 266
Cdd:PRK03007 156 NLTRASLDAACKYPWTRGEADGSP-------RRKFGFYDDDREVFAWVRQ---GAPAGRPCLeAQVMDWADDVAYSVHDV 225
                        250
                 ....*....|....*..
gi 15596321  267 EDSVEKGILDIRQLADL 283
Cdd:PRK03007 226 EDGVVSGRIDLRVLADP 242
PRK01286 PRK01286
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
40-495 2.19e-23

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 234934 [Multi-domain]  Cd Length: 336  Bit Score: 101.01  E-value: 2.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   40 DRGRIVNSAAVRRLQQKTQVFPLERNAAVRSRLTHSLEVQQTGRFIVRTLfrqlgpraaevGLDglegalESLVEMACLM 119
Cdd:PRK01286  32 DRDRIIHSKAFRRLKHKTQVFINPEGDHYRTRLTHTLEVAQIARTIARAL-----------RLN------EDLTEAIALG 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  120 HDVGNPPFGHFGEYAINdwfernldalfeRRIPPGQGdgllqqrmltdlkhFEGNAQAIRLVVKLLR----LNLTYTQTA 195
Cdd:PRK01286  95 HDLGHTPFGHAGEDALN------------ELMKEYGG--------------FEHNEQSLRVVDKLEKrydgLNLTWEVRE 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  196 GLLKYVRPayepkpdkaaanhyLNKKPGFYLSEEAFVdelrrvlgmrpgtrhpVAYimeaADDISYCLADIEDSVEKGIL 275
Cdd:PRK01286 149 GILKHSGP--------------RNAPLGTAATLEGQI----------------VRL----ADEIAYNNHDIDDGIRAGLI 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  276 DIRQLADLLVKkfAVHHSPdapipgdadnmsfqrmvdyslekaeREPINkvseffirlrvKMIHPLVQHAaqqfIDNFEA 355
Cdd:PRK01286 195 TLEDLPEDVRR--LLGETH-------------------------RRRIN-----------TLVVDLIKNT----QRNLAE 232
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  356 VHAGTlGRALMEDGSlpHAIVQTFKDVAMEWVFCHPEVETLELQGYRIIQGLLDFYapllrlpaeefqaLAegrqaaapH 435
Cdd:PRK01286 233 GAAAP-PLVSFSEEV--AEAMKELRRFLFENVYRHPKVKREREKAKRIVQDLFEYY-------------ME--------D 288
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321  436 PQLlvrrLPSQqikayleamkgvaedpLQRQWEFYHRCRMLQDFVSGMTDQHAQDEYRAL 495
Cdd:PRK01286 289 PEL----LPPE----------------YQNIAEEEGLERAVADYIAGMTDRYALREYRRL 328
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
67-140 5.83e-04

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 39.97  E-value: 5.83e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596321     67 AVRSRLTHSLEVQQTGRFIvrtlfrqlgprAAEVGLDGLEgalesLVEMACLMHDVGNPPFGHFGEYAINDWFE 140
Cdd:smart00471   1 SDYHVFEHSLRVAQLAAAL-----------AEELGLLDIE-----LLLLAALLHDIGKPGTPDSFLVKTSVLED 58
HD pfam01966
HD domain; HD domains are metal dependent phosphohydrolases.
71-129 4.36e-03

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 460398 [Multi-domain]  Cd Length: 110  Bit Score: 36.83  E-value: 4.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15596321    71 RLTHSLEVQQtgrfIVRTLFRQLGPRAAEvgldglegalesLVEMACLMHDVGNPPFGH 129
Cdd:pfam01966   1 RLEHSLRVAL----LARELAEELGELDRE------------LLLLAALLHDIGKGPFGD 43
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
69-135 6.76e-03

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 37.32  E-value: 6.76e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596321  69 RSRLTHSLEVQQTGRFIVRTLfrqlgpraaevgldGLEGALESLVEMACLMHDVGNPPFGHFGEYAI 135
Cdd:cd00077   1 EHRFEHSLRVAQLARRLAEEL--------------GLSEEDIELLRLAALLHDIGKPGTPDAITEEE 53
HD_assoc pfam13286
Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal ...
380-493 9.81e-03

Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal metal-dependent phosphohydrolases.


Pssm-ID: 433087 [Multi-domain]  Cd Length: 91  Bit Score: 35.58  E-value: 9.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596321   380 KDVAMEWVFCHPEVETLELQGYRIIQGLLDFYA--PLLrLPaEEFQALAEGRQAAAPHpqllvrrlpsqqikayleamkg 457
Cdd:pfam13286  15 KRFLFEYVYRHPRVQREEEKARRIIRELFEALMadPEL-LP-PEFRARWEAAGDDARA---------------------- 70
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 15596321   458 vaedplqrqwefyhrcRMLQDFVSGMTDQHAQDEYR 493
Cdd:pfam13286  71 ----------------RVVCDYIAGMTDRYALRLHR 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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