|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
43-451 |
7.82e-83 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 261.46 E-value: 7.82e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 43 QQVSEQLARATVYLLMDELVRYPASEQPYHLARIvrDKRFGFPVHLLQVKELDLDDDQRRRVVEGDTVMAlgkdGDSIRI 122
Cdd:PRK10604 36 RQSLDDLMKSSLYLMRSELREIPPRDWGKTLKEM--DLNLSFDLRIEPLSKYHLDPASQQRLREGEIVAL----DDQYTF 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 123 FAGILDTPWVLELGP------LFQMnpyppqllLLLGALCLSFIGLI----TYLLVRRLEQRLRSLEAAATRIARGSLDT 192
Cdd:PRK10604 110 LQRIPRSHYVLAVGPvpylyyLHQM--------RLLDIALLALIGLSlafpVFLWMRPHWQDMLKLEAAAQRLGDGHLAE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 193 RVEVRGGDSVGRLGAAFNHMAEHIHRLLTVQREMVRAVSHELRTPVARLRFGLEMIETAETDGArlkylEGMDNDIQDLD 272
Cdd:PRK10604 182 RIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSAAES-----QALNRDIGQLE 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 273 KLVDEMLTYARLEQGSPPLTYQRLELGVLVRQVVEEIAPLRREVLVSCEegalvPEELGSWIEAEPRYLHRALQNLLTNA 352
Cdd:PRK10604 257 ALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLD-----TPHQGDYGALDMRLMERVLDNLLNNA 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 353 LRHADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTRASGGHGLGLSIVRRIVYWHGGRASIGRSE 432
Cdd:PRK10604 332 LRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESE 411
|
410
....*....|....*....
gi 15596355 433 tLGGACFTLAWPRKAGLRD 451
Cdd:PRK10604 412 -LGGARFSFSWPVWHNLPQ 429
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
159-446 |
1.64e-59 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 199.78 E-value: 1.64e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 159 FIGLITYLLVRRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHMAEHIHRLLTVQREMVRAVSHELRTPV 238
Cdd:COG5002 101 LLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPL 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 239 ARLRFGLEMIET--AETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLTYQRLELGVLVRQVVEEIAPLRREV 316
Cdd:COG5002 181 TSIRGYLELLLDgaADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEK 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 317 LVSCEegaLVPEELGSWIEAEPRYLHRALQNLLTNALRH--ADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPF 394
Cdd:COG5002 261 GIELE---LDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYtpEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERF 337
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 15596355 395 LRLDDSRTRASGGHGLGLSIVRRIVYWHGGRASIgRSETLGGACFTLAWPRK 446
Cdd:COG5002 338 YRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWV-ESEPGKGTTFTITLPLA 388
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
208-447 |
8.91e-55 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 182.41 E-value: 8.91e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 208 AFNHMAEHIHRLLTVQREMVRAVSHELRTPVARLRFGLEMIE--TAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLE 285
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLdeEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 286 QGSPPLTYQRLELGVLVRQVVEEIAPLRREVLVSCEegaLVPEELGSWIEAEPRYLHRALQNLLTNALRH--ADRRVRIS 363
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLE---LDLPPELPLVYADPELLEQVLANLLDNAIKYspPGGTITIS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 364 YRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDdsRTRASGGHGLGLSIVRRIVYWHGGRASIgRSETLGGACFTLAW 443
Cdd:COG2205 158 ARREGDGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWV-ESEPGGGTTFTVTL 234
|
....
gi 15596355 444 PRKA 447
Cdd:COG2205 235 PLAE 238
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
159-445 |
1.17e-54 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 185.11 E-value: 1.17e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 159 FIGLITYLLVRRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHMAEHIHRLLTVQREMVRAVSHELRTPV 238
Cdd:COG0642 46 LLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 239 ARLRFGLEMIEtAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLTYQRLELGVLVRQVVEEIAPL--RREV 316
Cdd:COG0642 126 TAIRGYLELLL-EELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLaeEKGI 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 317 LVSCEegalVPEELGsWIEAEPRYLHRALQNLLTNALRHADR--RVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPF 394
Cdd:COG0642 205 ELELD----LPDDLP-TVRGDPDRLRQVLLNLLSNAIKYTPEggTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPF 279
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 15596355 395 LRLDDSRTraSGGHGLGLSIVRRIVYWHGGRASIgRSETLGGACFTLAWPR 445
Cdd:COG0642 280 FRTDPSRR--GGGTGLGLAIVKRIVELHGGTIEV-ESEPGKGTTFTVTLPL 327
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-445 |
7.27e-54 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 175.31 E-value: 7.27e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTNALRHADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTRASGGHGLGLSIVRRIVY 420
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVAL 80
|
90 100
....*....|....*....|....*
gi 15596355 421 WHGGRASIGRSEtLGGACFTLAWPR 445
Cdd:cd16939 81 WHGGHVECDDSE-LGGACFRLTWPR 104
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
158-438 |
5.48e-46 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 165.08 E-value: 5.48e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 158 SFIGLIT----YLLVRRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHMAEHIhRLLTVQREMVRA-VSH 232
Cdd:PRK09467 160 LAIGLLSvaggWLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGI-KQLEDDRTLLMAgVSH 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 233 ELRTPVARLRFGLEMIetAETDGarlkYL-EGMDNDIQDLDKLVDEMLTYARLEQGSPpltYQRLELGVLVRQVVEEIAP 311
Cdd:PRK09467 239 DLRTPLTRIRLATEMM--SEEDG----YLaESINKDIEECNAIIEQFIDYLRTGQEMP---MEMADLNALLGEVIAAESG 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 312 LRREVlvsceEGALVPEELGswIEAEPRYLHRALQNLLTNALRHADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLF 391
Cdd:PRK09467 310 YEREI-----ETALQPGPIE--VPMNPIAIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLF 382
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 15596355 392 TPFLRLDDSRTraSGGHGLGLSIVRRIVYWHGGRASIGRSEtLGGAC 438
Cdd:PRK09467 383 QPFTRGDSARG--SSGTGLGLAIVKRIVDQHNGKVELGNSE-EGGLS 426
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
162-444 |
2.50e-41 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 152.67 E-value: 2.50e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 162 LITYLLVRRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHMAEHIHRLLTVQREMVRAVSHELRTPVARL 241
Cdd:NF012163 179 LAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 242 RFGLEMIEtaetDGARL---KYLEGMDNDIQDLDKLVDEMLTYARLEQGSppLTYQR--LELGVLVRQVVEEIAP-LRRE 315
Cdd:NF012163 259 RAELEAIQ----DGIRKftpESLDSLQAEVGTLTKLVDDLHDLSMSDEGA--LAYQKasVDLVPLLEVEGGAFRErFASA 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 316 VLVSCEEGALVPEELGswieaEPRYLHRALQNLLTNALRHADR--RVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTP 393
Cdd:NF012163 333 GLELEVSLPDSSLVFG-----DRDRLMQLFNNLLENSLRYTDSggSLHISASQRPKEVTLTVADSAPGVSDEQLARLFER 407
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 15596355 394 FLRLDDSRTRASGGHGLGLSIVRRIVYWHGGRASIGRSeTLGGACFTLAWP 444
Cdd:NF012163 408 FYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHS-PLGGLRIVVTLP 457
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
160-450 |
8.41e-40 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 149.41 E-value: 8.41e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 160 IGLITYLLVRRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHMAEHIHR-------LLTVQREMVRAVSH 232
Cdd:NF040691 201 LGLIAWLVTRQVVAPVRSAARTAERFAAGDLSERMPVKGEDDLARLARSFNQMADSLQRqirqleeLSRLQQRFVSDVSH 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 233 ELRTPVARLRFGLEMI--ETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLTYQRLELGVLVRQVVEEIA 310
Cdd:NF040691 281 ELRTPLTTIRMAADVIhdSRDDFDPATARSAELLHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALR 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 311 PL--RR--EVLVSCEEGALVpeelgswIEAEPRYLHRALQNLLTNALRHAD-RRVRISYRVSLERCRVDVEDDGPGVPEA 385
Cdd:NF040691 361 QLaeRAgvELRVDAPGTPVV-------AEVDPRRVERVLRNLVVNAIEHGEgKPVVVTVAQDDTAVAVTVRDHGVGLKPG 433
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15596355 386 QWERLFTPFLRLDDSRTRASGGHGLGLSIVRRIVYWHGGRASIGrSETLGGACFTLAWPRKAGLR 450
Cdd:NF040691 434 EVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAW-GRPGQGSQFRLTLPRVAGDR 497
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
167-444 |
2.03e-38 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 144.69 E-value: 2.03e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 167 LVRRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGR-LGAAFNHMAEHIHRLLTVQREMVRAVSHELRTPVARLRFGL 245
Cdd:PRK09470 186 LAWSLAKPARKLKNAADEVAQGNLRQHPELETGPQEFRqAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLAT 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 246 EMIETAETDGarlKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPpltyqrlelgvLVRQVVEeIAPLRREVLVSCEEGA- 324
Cdd:PRK09470 266 ALLRRRQGES---KELERIETEAQRLDSMINDLLVLSRNQQKNH-----------LERETFK-ANSLWSEVLEDAKFEAe 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 325 ------LVPEELGSW-IEAEPRYLHRALQNLLTNALRHADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRL 397
Cdd:PRK09470 331 qmgkslTVSAPPGPWpINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRV 410
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 15596355 398 DDSRTRASGGHGLGLSIVRRIVYWHGGRASIGRSEtLGGACFTLAWP 444
Cdd:PRK09470 411 DEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSP-LGGLRLTIWLP 456
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
162-447 |
5.34e-36 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 137.40 E-value: 5.34e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 162 LITYLLVRRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHMA---------------------------- 213
Cdd:COG5000 24 WLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTdqlkeqreeleerrryletilenlpagv 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 --------------------------------------------------------------------------------
Cdd:COG5000 104 ivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgrrtllvrasplrddgyv 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 214 ---EHIHRLLTVQR-----EMVRAVSHELRTPVA-------RLRFGLEMiETAETDGARLKYLEGMDNDIQDLDKLVDEM 278
Cdd:COG5000 184 ivfDDITELLRAERlaawgELARRIAHEIKNPLTpiqlsaeRLRRKLAD-KLEEDREDLERALDTIIRQVDRLKRIVDEF 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 279 LTYARLeqgsPPLTYQRLELGVLVRQVVEEIAPLRREVLVSCEegALVPEELGsWIEAEPRYLHRALQNLLTNALRHADR 358
Cdd:COG5000 263 LDFARL----PEPQLEPVDLNELLREVLALYEPALKEKDIRLE--LDLDPDLP-EVLADRDQLEQVLINLLKNAIEAIEE 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 359 --RVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLrlddsrTRASGGHGLGLSIVRRIVYWHGGRASIgRSETLGG 436
Cdd:COG5000 336 ggEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIEL-ESRPGGG 408
|
410
....*....|.
gi 15596355 437 ACFTLAWPRKA 447
Cdd:COG5000 409 TTFTIRLPLAE 419
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
216-440 |
7.22e-35 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 132.33 E-value: 7.22e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 216 IHRLLTVQREMVRAVSHELRTPVARLRFGLE-MIETAETDGARL-KYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLTY 293
Cdd:TIGR02966 107 LRRLEQMRRDFVANVSHELRTPLTVLRGYLEtLADGPDEDPEEWnRALEIMLEQSQRMQSLVEDLLTLSRLESAASPLED 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 294 QRLELGVLVRQVVEEIAPL--RREVLVSCE-EGALvpeelgsWIEAEPRYLHRALQNLLTNALRH--ADRRVRISYRVSL 368
Cdd:TIGR02966 187 EPVDMPALLDHLRDEAEALsqGKNHQITFEiDGGV-------DVLGDEDELRSAFSNLVSNAIKYtpEGGTITVRWRRDG 259
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15596355 369 ERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTRASGGHGLGLSIVRRIVYWHGGRASIgrSETLG-GACFT 440
Cdd:TIGR02966 260 GGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEI--ESELGkGSTFS 330
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
20-448 |
2.93e-34 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 134.14 E-value: 2.93e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 20 AEHAVTVYTQASAAENLVLSGEVQQVSEQLARATVYLLMDELVRYPASEQPYHLARIVRDKRFGFPVHLLQVKELDLDDD 99
Cdd:COG4251 79 ALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLL 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 100 QRRRVVEGDTVMALGKDGDSIRIFAGILDTPWVLELGPLFQMNPYPPQLLLLLGALCLSFIGLITYLLVRRLEQRLRSLE 179
Cdd:COG4251 159 LLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLL 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 180 AAATRIARGSLDTRVEVRGGDSVGRLGAAfnhMAEHIHRLLTVQREM---VRAVSHELRTPVARLRFGLEMIEtaETDGA 256
Cdd:COG4251 239 LLLILLLLLLILVLELLELRLELEELEEE---LEERTAELERSNEELeqfAYVASHDLREPLRKISGFSQLLE--EDYGD 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 257 RL-----KYLEGMDNDIQDLDKLVDEMLTYARLEQGspPLTYQRLELGVLVRQVVEEIAPLRREVLVSCEEGALvPEelg 331
Cdd:COG4251 314 KLdeegrEYLERIRDAAERMQALIDDLLAYSRVGRQ--ELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPL-PT--- 387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 332 swIEAEPRYLHRALQNLLTNALRHADR----RVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTRasGG 407
Cdd:COG4251 388 --VRGDPTLLRQVFQNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEY--EG 463
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 15596355 408 HGLGLSIVRRIVYWHGGRASIgRSETLGGACFTLAWPRKAG 448
Cdd:COG4251 464 TGIGLAIVKKIVERHGGRIWV-ESEPGEGATFYFTLPKAPA 503
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
160-427 |
1.27e-33 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 131.36 E-value: 1.27e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 160 IGLITYLLVRRLEQRLRSLEAAATRIARGSLDTRVEV-RGGDSVGRLGAAFNHMAEHIHRLLTVQREMVRAVSHELRTPV 238
Cdd:TIGR01386 177 TALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPsRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 239 ARLRFGLEMIETAETDGARLK-YLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLTYQRLELGVLVRQVVEEIAPLRREVL 317
Cdd:TIGR01386 257 TNLLGQTQVALSQPRTGEEYReVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERG 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 318 VSCE-EGALVpeelgswIEAEPRYLHRALQNLLTNALRHADRRVRIsyRVSLER----CRVDVEDDGPGVPEAQWERLFT 392
Cdd:TIGR01386 337 VRIRvEGEGL-------VRGDPQMFRRAISNLLSNALRHTPDGGTI--TVRIERrsdeVRVSVSNPGPGIPPEHLSRLFD 407
|
250 260 270
....*....|....*....|....*....|....*
gi 15596355 393 PFLRLDDSRTRASGGHGLGLSIVRRIVYWHGGRAS 427
Cdd:TIGR01386 408 RFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRAS 442
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
162-444 |
2.78e-30 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 122.05 E-value: 2.78e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 162 LITYLLVRRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHMAEHIHRLLTVQREMVRAVSHELRTPVARL 241
Cdd:PRK10549 179 LATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 242 RFGLEMIEtaetDGARL---KYLEGMDNDIQDLDKLVDEMLTYARLEQGSppLTYQRLELGVLvrQVVEEIAPLRREVLV 318
Cdd:PRK10549 259 RGELEAIQ----DGVRKftpESVASLQAEVGTLTKLVDDLHQLSLSDEGA--LAYRKTPVDLV--PLLEVAGGAFRERFA 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 319 ScEEGAL---VPEElgSWIEAEPRYLHRALQNLLTNALRHADR--RVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTP 393
Cdd:PRK10549 331 S-RGLTLqlsLPDS--ATVFGDPDRLMQLFNNLLENSLRYTDSggSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFER 407
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 15596355 394 FLRLDDSRTRASGGHGLGLSIVRRIVYWHGGRASIGRSeTLGGACFTLAWP 444
Cdd:PRK10549 408 FYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHS-PFGGVSITVELP 457
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-444 |
1.76e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 110.88 E-value: 1.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTNALRHADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTRASGGHGLGLSIVRRIVY 420
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|....
gi 15596355 421 WHGGRASIGRSETlGGACFTLAWP 444
Cdd:cd16949 81 QHGGKIKASNRKP-GGLRVRIWLP 103
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
341-441 |
4.09e-29 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 109.61 E-value: 4.09e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTNALRHA--DRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTraSGGHGLGLSIVRRI 418
Cdd:cd00075 1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSRE--GGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|...
gi 15596355 419 VYWHGGRASIgRSETLGGACFTL 441
Cdd:cd00075 79 VEAHGGRITV-ESEPGGGTTFTV 100
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
336-446 |
4.66e-29 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 110.05 E-value: 4.66e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 336 AEPRYLHRALQNLLTNALRHADR--RVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDsRTRASGGHGLGLS 413
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|...
gi 15596355 414 IVRRIVYWHGGRASIgRSETLGGACFTLAWPRK 446
Cdd:smart00387 80 IVKKLVELHGGEISV-ESEPGGGTTFTITLPLE 111
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
160-446 |
1.81e-28 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 115.28 E-value: 1.81e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 160 IGLITYLLVRRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHMAEHIHRLLTVQREMVRA---------- 229
Cdd:COG4191 67 LLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSeklaalgela 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 230 --VSHELRTPVA----RLRFGLEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPpltyQRLELGVLVR 303
Cdd:COG4191 147 agIAHEINNPLAailgNAELLRRRLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEER----EPVDLNELID 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 304 QVVEEIAPL--RREVLVSCEegalVPEELGsWIEAEPRYLHRALQNLLTNAlRHA-----DRRVRISYRVSLERCRVDVE 376
Cdd:COG4191 223 EALELLRPRlkARGIEVELD----LPPDLP-PVLGDPGQLEQVLLNLLINA-IDAmeegeGGRITISTRREGDYVVISVR 296
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 377 DDGPGVPEAQWERLFTPFLrlddSRTRASGGHGLGLSIVRRIVYWHGGRASIgRSETLGGACFTLAWPRK 446
Cdd:COG4191 297 DNGPGIPPEVLERIFEPFF----TTKPVGKGTGLGLSISYGIVEKHGGRIEV-ESEPGGGTTFTITLPLA 361
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
161-447 |
5.14e-28 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 115.71 E-value: 5.14e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 161 GLITYLLVRRLeqrlRSLEAAATRIARGsldTRVEV--RGGDSVGRLGAAFNHMAE------HIHRlltvqreMVRAVSH 232
Cdd:PRK11100 200 AGVVWWLNRSI----RRLTRYADAVTEG---KPVPLpkLGSSELRELAQALESMRVklegkaYVEQ-------YVQTLTH 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 233 ELRTPVARLRFGLEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLTYQRLELGVLVRQVVEEIAPL 312
Cdd:PRK11100 266 ELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQ 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 313 RREVLVSCEEGAlvpeeLGSWIEAEPRYLHRALQNLLTNAL--RHADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERL 390
Cdd:PRK11100 346 AAAKGITLRLRP-----DDARVLGDPFLLRQALGNLLDNAIdfSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRI 420
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 15596355 391 FTPFLRL--DDSRTRASgghGLGLSIVRRIVYWHGGRASIgRSETLGGACFTLAWPRKA 447
Cdd:PRK11100 421 FERFYSLprPANGRKST---GLGLAFVREVARLHGGEVTL-RNRPEGGVLATLTLPRHF 475
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
338-446 |
3.11e-26 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 102.06 E-value: 3.11e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 338 PRYLHRALQNLLTNALRHADRRVRISYRVSLE-RCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTrasGGHGLGLSIVR 416
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHAAKAGEITVTLSEGgELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGG---GGTGLGLSIVR 79
|
90 100 110
....*....|....*....|....*....|
gi 15596355 417 RIVYWHGGRASIgRSETLGGACFTLAWPRK 446
Cdd:pfam02518 80 KLVELLGGTITV-ESEPGGGTTVTLTLPLA 108
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
159-444 |
3.29e-26 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 108.93 E-value: 3.29e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 159 FIGLityLLVRRLEQRLRSLEAAATRIARGSLDTRVEVRGGDS--VGRLGAAFNHMAEHIHrlLTVQREMV--RAVSHEL 234
Cdd:NF012226 75 IIGM---KLAQRFIVPINFLADAAKKISQGDLSARAEDSQIHSaeISELMHNFNDMAQKLE--SSVKNAQVwnAAIAHEL 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 235 RTPVARLRFGLEMIETA--ETDGARLKYLEgmdNDIQDLDKLVDEMLTYARLEQGSPPLTYQRLELGVLVRQVVE----- 307
Cdd:NF012226 150 RTPITILQGRLQGILDGvfEPDPALFKSLL---NQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVLKmfedr 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 308 -EIAPLR-----REVLVSCEEgalvpeelgswieaepRYLHRALQNLLTNALRHADR-RVRISYRVSLERCRVDVEDDGP 380
Cdd:NF012226 227 lEQAQLTivlnlTATPVFCDR----------------RRIEQVLIALIDNAIRYANAgKLKISSSVIQDDWILQIEDEGP 290
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596355 381 GVPEAQWERLFTPFLRLDDSRTRASGGHGLGLSIVRRIVYWHGGRasIGRSETLGGACFTLAWP 444
Cdd:NF012226 291 GIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGS--IEYSNSQGNSVFTIKLP 352
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
160-447 |
8.07e-25 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 106.39 E-value: 8.07e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 160 IGLITYLLVRRLEQRLRSLEAAATRIARGSLDTRVEvrgGDSV----GRLGAAFNHMAEHIHRLLTVQREMVRAVSHELR 235
Cdd:PRK09835 198 IVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLD---PQTVpielEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIR 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 236 TPVARLrfgLEMIETAETDGARLKYLEGMD----NDIQDLDKLVDEMLTYARLEQGSPPLTYQRLELGVLVRQVVEEIAP 311
Cdd:PRK09835 275 TPITNL---ITQTEIALSQSRSQKELEDVLysnlEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEA 351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 312 LRREVLVsceegALVPEELGSWIEAEPRYLHRALQNLLTNALRH--ADRRVRISYRVSLERCRVDVEDDGPGVPEAQWER 389
Cdd:PRK09835 352 WAEERGV-----ELRFVGDPCQVAGDPLMLRRAISNLLSNALRYtpAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPR 426
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 15596355 390 LFTPFLRLDDSRTRASGGHGLGLSIVRRIVYWHGGRASIgrSETLGGACFTLAWPRKA 447
Cdd:PRK09835 427 LFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAV--TSDARGTRFVISLPRLE 482
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
215-446 |
4.39e-24 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 103.00 E-value: 4.39e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 215 HIHRLLTVqREMVRAVSHELRTPVARLRFGLEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEqgspPLTYQ 294
Cdd:COG3852 128 RAEKLAAV-GELAAGLAHEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPR----PPERE 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 295 RLELGVLVRQVVEEIAP-LRREVLVSCEEGALVPEelgswIEAEPRYLHRALQNLLTNAlRHA-------------DRRV 360
Cdd:COG3852 203 PVNLHEVLERVLELLRAeAPKNIRIVRDYDPSLPE-----VLGDPDQLIQVLLNLVRNA-AEAmpeggtitirtrvERQV 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 361 RISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLrlddsRTRAsGGHGLGLSIVRRIVYWHGGRASIgRSETLGGACFT 440
Cdd:COG3852 277 TLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFF-----TTKE-KGTGLGLAIVQKIVEQHGGTIEV-ESEPGKGTTFR 349
|
....*.
gi 15596355 441 LAWPRK 446
Cdd:COG3852 350 IYLPLE 355
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-444 |
3.76e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 93.68 E-value: 3.76e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 337 EPRYLHRALQNLLTNALRHADR--RVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTRASGGHGLGLSI 414
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 15596355 415 VRRIVYWHGGRASIGRSEtLGGACFTLAWP 444
Cdd:cd16946 81 CHNIALAHGGTISAEHSP-LGGLRLVLTLP 109
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
160-444 |
5.24e-22 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 99.47 E-value: 5.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 160 IGLITYLLV-RRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLG---AAFNHMAEHIHRLLTVQREMVR------- 228
Cdd:TIGR02956 344 LVFIMWRVVyRSVILRLNQHTQALLRLALGDLDISLDARGDDELAHMGraiEAFRDTAAHNLKLQADERQVAQelqehke 423
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 229 ----------------------------------------------AVSHELRTPVARLRFGLEMIETAETDGARLKYLE 262
Cdd:TIGR02956 424 sleqlvaqrtqelaetnerlnaevknhakaraeaeeanraksaflaTMSHEIRTPLNGILGTLELLGDTGLTSQQQQYLQ 503
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 263 GMDNDIQDLDKLVDEMLTYARLEQGSPPLTYQRLELGVLVRQVVEEIAPLRREVLVSCEEGalVPEELGSWIEAEPRYLH 342
Cdd:TIGR02956 504 VINRSGESLLDILNDILDYSKIEAGHLSISPRPFDLNALLDDVHHLMVSRAQLKGIQLRLN--IPEQLPNWWQGDGPRIR 581
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 343 RALQNLLTNALRHADR-RVRISYRVSLERC-RVDVEDDGPGVPEAQWERLFTPFLRLDDSRTraSGGHGLGLSIVRRIVY 420
Cdd:TIGR02956 582 QVLINLVGNAIKFTDRgSVVLRVSLNDDSSlLFEVEDTGCGIAEEEQATLFDAFTQADGRRR--SGGTGLGLAISQRLVE 659
|
330 340
....*....|....*....|....*
gi 15596355 421 WHGGraSIGRSETLG-GACFTLAWP 444
Cdd:TIGR02956 660 AMDG--ELGVESELGvGSCFWFTLP 682
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
217-425 |
1.94e-21 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 95.03 E-value: 1.94e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 217 HRL-LTVQREMVRA--VSHELRTPVARLRFGLEMIE-TAETDGARLkylegmdndIQDLDKL---VDEMLTYARLEQGSP 289
Cdd:PRK10755 128 SRLtSTLDQERLFTadVAHELRTPLAGIRLHLELLEkQHHIDVAPL---------IARLDQMmhtVEQLLQLARAGQSFS 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 290 PLTYQRLELgvlvrqVVEEIAPLRREVLVSCEEGA---LVPE-ELGSWIEAEPRYLHRALQNLLTNALRHADRRVRISYR 365
Cdd:PRK10755 199 SGHYQTVKL------LEDVILPSQDELSEMLEQRQqtlLLPEsAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIK 272
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596355 366 VSLER--CRVDVEDDGPGVPEAQWERLFTPFLRLDdsrtRASGGHGLGLSIVRRIVYWHGGR 425
Cdd:PRK10755 273 LSQEDggAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQ 330
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
216-446 |
1.06e-20 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 93.92 E-value: 1.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 216 IHRLLTVQREMVRAVSHELRTPVARLRFGLEMIETAETDGA-RLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLTYQ 294
Cdd:PRK11006 197 MHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGAlREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNE 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 295 RLELGVLVRQVVEEIAPL---RREVLVSCEEGALV---PEELGSwieaeprylhrALQNLLTNALRH--ADRRVRISYRV 366
Cdd:PRK11006 277 KVDVPMMLRVLEREAQTLsqgKHTITFEVDNSLKVfgnEDQLRS-----------AISNLVYNAVNHtpEGTHITVRWQR 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 367 SLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTRASGGHGLGLSIVRRIVYWHGGRASIgRSETLGGACFTLAWPRK 446
Cdd:PRK11006 346 VPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEI-ESEVGKGTRFSFVLPER 424
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
225-448 |
1.13e-20 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 94.65 E-value: 1.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 225 EMVRAVSHELRTPVARLRFGLEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPpltyQRLELGVLVRQ 304
Cdd:PRK11360 392 ELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQW----QPVSLNALVEE 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 305 VVE--EIAPLRREVLVSCEEGALVPEelgswIEAEPRYLHRALQNLLTNALRHADRRVRISYRVSLE---RCRVDVEDDG 379
Cdd:PRK11360 468 VLQlfQTAGVQARVDFETELDNELPP-----IWADPELLKQVLLNILINAVQAISARGKIRIRTWQYsdgQVAVSIEDNG 542
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596355 380 PGVPEAQWERLFTPFLrlddsRTRASGGhGLGLSIVRRIVYWHGGRASIgRSETLGGACFTLAWPRKAG 448
Cdd:PRK11360 543 CGIDPELLKKIFDPFF-----TTKAKGT-GLGLALSQRIINAHGGDIEV-ESEPGVGTTFTLYLPINPQ 604
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
160-443 |
1.19e-20 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 93.95 E-value: 1.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 160 IGLITYLL--VRRLEQ--RLRSLEAAAtriargSLDT-RV--EVRGgdsvgrLGAAFNHMAEHIHRLLTVQREMVRAVSH 232
Cdd:PRK10337 179 MVLLGRELapLKKLALalRMRDPDSET------PLNAtGVpsEVRP------LVEALNQLFARTHAMMVRERRFTSDAAH 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 233 ELRTPVARLRFGLEMIETAETD-GARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLTYQRLELGVLVRQVVEEIAP 311
Cdd:PRK10337 247 ELRSPLAALKVQTEVAQLSDDDpQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIYH 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 312 LRREVLVsceEGALVPEELGSWIEAEPRYLHRALQNLLTNALRHADRRVRISyrVSLERCRVDVEDDGPGVPEAQWERLF 391
Cdd:PRK10337 327 TAQQAGI---DVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVD--VTLNARNFTVRDNGPGVTPEALARIG 401
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 15596355 392 TPFLRlddSRTRASGGHGLGLSIVRRIVYWHGGRASIGRSETlGGACFTLAW 443
Cdd:PRK10337 402 ERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPE-GGFEAKVSW 449
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-438 |
2.40e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 85.58 E-value: 2.40e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTNALRHADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTraSGGHGLGLSIVRRIVY 420
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISD 78
|
90
....*....|....*...
gi 15596355 421 WHGGRASIGRSETlGGAC 438
Cdd:cd16950 79 AHGGSLTLANRAG-GGLC 95
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
337-444 |
7.19e-20 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 84.47 E-value: 7.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 337 EPRYLHRALQNLLTNALRHADRRVRISYRVSL---ERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTRASGGHGLGLS 413
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKfrlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|.
gi 15596355 414 IVRRIVYWHGGRASIGRSETlGGACFTLAWP 444
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPG-GGALFQVELP 110
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-439 |
8.81e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 84.99 E-value: 8.81e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 345 LQNLLTNALRHADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTrasgGHGLGLSIVRRIVYWHGG 424
Cdd:cd16954 42 LGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVEQYGG 117
|
90
....*....|....*
gi 15596355 425 RASIGRSEtLGGACF 439
Cdd:cd16954 118 ELSLSDSP-LGGARF 131
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
159-444 |
1.83e-19 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 91.24 E-value: 1.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 159 FIGLITYLLVRR-LEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHM---------------AEHIHRLLTV 222
Cdd:PRK15347 308 LLTSVLFLLLRRyLAKPLWRFVDIINKTGPAALEPRLPENRLDELGSIAKAYNQLldtlneqydtlenkvAERTQALAEA 387
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 223 QREMVRA----------VSHELRTPVARLRFGLEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLT 292
Cdd:PRK15347 388 KQRAEQAnkrksehlttISHEIRTPLNGVLGALELLQNTPLTAEQMDLADTARQCTLSLLAIINNLLDFSRIESGQMTLS 467
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 293 YQRLELGVLVRQVVEEI------APLRREVLVSCEegalVPEELgswiEAEPRYLHRALQNLLTNALRHADR-RVRISYR 365
Cdd:PRK15347 468 LEETALLPLLDQAMLTIqgpaqsKSLTLRTFVGAH----VPLYL----HLDSLRLRQILVNLLGNAVKFTETgGIRLRVK 539
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 366 VSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSrtraSGGHGLGLSIVRRIVYWHGGRASIgrSETLG-GACFTLAWP 444
Cdd:PRK15347 540 RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTH----SQGTGLGLTIASSLAKMMGGELTL--FSTPGvGSCFSLVLP 613
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
345-441 |
2.35e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 82.93 E-value: 2.35e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 345 LQNLLTNALRHADR---RVRISYR---VSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTRASGGHGLGLSIVRRI 418
Cdd:cd16922 5 LLNLLGNAIKFTEEgevTLRVSLEeeeEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKKL 84
|
90 100
....*....|....*....|....
gi 15596355 419 VYWHGGraSIGRSETLG-GACFTL 441
Cdd:cd16922 85 VELMGG--DISVESEPGqGSTFTF 106
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
158-444 |
4.55e-19 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 89.80 E-value: 4.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 158 SFIGLITYLLVRRLEQRLRSLEAAATRiargSLDTRVEVRG-------GDSVGRLGAAFNHMAEHIHRLLTVQREMVRAV 230
Cdd:TIGR03785 417 SIGTLALFGFASWISWRIRRLSDDAEA----AIDSQGRISGaipasrsRDEIGDLSRSFAQMVARLRQYTHYLENMSSRL 492
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 231 SHELRTPVARLRFGLEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLTYQRLELGVLV---RQVVE 307
Cdd:TIGR03785 493 SHELRTPVAVVRSSLENLELQALEQEKQKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEVLsgcMQGYQ 572
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 308 EIAPLRREVLVSCEEGALVpeeLGSwieaePRYLHRALQNLLTNALR--HADRRVRISYRVSLERCRVDVEDDGPGVPEA 385
Cdd:TIGR03785 573 MTYPPQRFELNIPETPLVM---RGS-----PELIAQMLDKLVDNAREfsPEDGLIEVGLSQNKSHALLTVSNEGPPLPED 644
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596355 386 QWERLFTPFLRLddsrtRASGGH-----GLGLSIVRRIVYWHGGRASIGRSETLGGACFTLAWP 444
Cdd:TIGR03785 645 MGEQLFDSMVSV-----RDQGAQdqphlGLGLYIVRLIADFHQGRIQAENRQQNDGVVFRISLP 703
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
220-444 |
2.54e-17 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 84.70 E-value: 2.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 220 LTVQREMVR-----AVSHELRTPVARLrFG---LEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPL 291
Cdd:PRK10490 656 LASEREQLRnallaALSHDLRTPLTVL-FGqaeILTLDLASEGSPHARQASEIRQQVLNTTRLVNNLLDMARIQSGGFNL 734
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 292 TYQRLELGVLVRQVVEEIAPL--RREVLVSceegalVPEELgSWIEAEPRYLHRALQNLLTNALRHADRRVR--ISYRVS 367
Cdd:PRK10490 735 RKEWLTLEEVVGSALQMLEPGlsGHPINLS------LPEPL-TLIHVDGPLFERVLINLLENAVKYAGAQAEigIDAHVE 807
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596355 368 LERCRVDVEDDGPGVPEAQWERLFTPFLRLDdsRTRASGGHGLGLSIVRRIVYWHGGRASIGRSETlGGACFTLAWP 444
Cdd:PRK10490 808 GERLQLDVWDNGPGIPPGQEQLIFDKFARGN--KESAIPGVGLGLAICRAIVEVHGGTIWAENRPE-GGACFRVTLP 881
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
169-444 |
3.42e-17 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 84.57 E-value: 3.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 169 RRLEQRLRSLEAAATRIARGSLDT----RVEVRGGDSVGRLGAAF-------NHMAEHIHRL----------LTVQREMV 227
Cdd:PRK11466 354 RSVTRPLAEQTQALQRLLDGDIDSpfpeTAGVRELDTIGRLMDAFrsnvhalNRHREQLAAQvkartaelqeLVIEHRQA 433
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 228 RA---------------VSHELRTPVARLRFGLEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLT 292
Cdd:PRK11466 434 RAeaekasqaksaflaaMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVS 513
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 293 YQrlELGVLVRQVVEEIAPL------RREVLVSCEegalVPEELGSWIEAEPRYLHRALQNLLTNALRHADR-RVRISYR 365
Cdd:PRK11466 514 VS--DEPFEPRPLLESTLQLmsgrvkGRPIRLATD----IADDLPTALMGDPRRIRQVITNLLSNALRFTDEgSIVLRSR 587
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 366 VSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRtrasGGHGLGLSIVRRIVYWHGGRASIgrSETLG-GACFTLAWP 444
Cdd:PRK11466 588 TDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSA--TSTPEvGSCFCLRLP 661
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-444 |
4.63e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 76.60 E-value: 4.63e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTNAL--RHADR--RVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDdSRTrASGGHGLGLSIVR 416
Cdd:cd16921 1 LGQVLTNLLGNAIkfRRPRRppRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH-SRE-EYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*...
gi 15596355 417 RIVYWHGGRASIgRSETLGGACFTLAWP 444
Cdd:cd16921 79 KIIERHGGRIWL-ESEPGEGTTFYFTLP 105
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
220-444 |
1.74e-16 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 80.77 E-value: 1.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 220 LTVQREMVRAVSHELRTP-------VARLRFGLEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLT 292
Cdd:PRK09303 148 LKFKDRVLAMLAHDLRTPltaaslaLETLELGQIDEDTELKPALIEQLQDQARRQLEEIERLITDLLEVGRTRWEALRFN 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 293 YQRLELGVLVRQVVEEIAPLRREVLVSCEEGalVPEELGSwIEAEPRYLHRALQNLLTNALRH--ADRRVRIS--YRVSl 368
Cdd:PRK09303 228 PQKLDLGSLCQEVILELEKRWLAKSLEIQTD--IPSDLPS-VYADQERIRQVLLNLLDNAIKYtpEGGTITLSmlHRTT- 303
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596355 369 ERCRVDVEDDGPGVPEAQWERLFTPFLRLDdsRTRASGGHGLGLSIVRRIVYWHGGRASIgRSETLGGACFTLAWP 444
Cdd:PRK09303 304 QKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWV-DSEPGQGSCFHFTLP 376
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
159-444 |
3.00e-15 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 78.19 E-value: 3.00e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 159 FIGLITYLLV-RRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNH--------------MAEHIHR----L 219
Cdd:COG4192 338 LAVLINYFYVrRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLLRVfrdqaiektqeletEIEERKRieknL 417
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 220 LTVQREMVRA------------VSHELRTPVARLR---FGLEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARl 284
Cdd:COG4192 418 RQTQDELIQAakmavvgqtmtsLAHELNQPLNAMSmylFSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSR- 496
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 285 eQGSPPLTYqrlelgVLVRQVVE---EIAPLRREVlvscEEGALV-PEELgsWIEAEPRYLHRALQNLLTNALRHADRRV 360
Cdd:COG4192 497 -KSDTPLQP------VDLRQVIEqawELVESRAKP----QQITLHiPDDL--MVQGDQVLLEQVLVNLLVNALDAVATQP 563
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 361 RISYRV--SLERCRVDVEDDGPGVPEAqwERLFTPFLrlddsrTRASGGHGLGLSIVRRIVYWHGGRASIGRSETlGGAC 438
Cdd:COG4192 564 QISVDLlsNAENLRVAISDNGNGWPLV--DKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLASTLE-RGAM 634
|
....*.
gi 15596355 439 FTLAWP 444
Cdd:COG4192 635 VILEFN 640
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
220-444 |
3.76e-15 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 77.32 E-value: 3.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 220 LTVQREMVRAVSHELRTPVARLRFGLEMIEtAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSppltYQRLELG 299
Cdd:COG5809 267 LSVVGELAAGIAHEIRNPLTSLKGFIQLLK-DTIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAIK----YEPKDLN 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 300 VLVRQVVEEIAP--LRREVLVSCEEGALVPEelgswIEAEPRYLHRALQNLLTNALRHADRRVRISYRVSLERC---RVD 374
Cdd:COG5809 342 TLIEEVIPLLQPqaLLKNVQIELELEDDIPD-----ILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDdkvVIS 416
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596355 375 VEDDGPGVPEAQWERLFTPFLrlddsrTRASGGHGLGLSIVRRIVYWHGGraSIGRSETLG-GACFTLAWP 444
Cdd:COG5809 417 VTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGG--KITVESEVGkGTTFSITLP 479
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-435 |
3.78e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 71.28 E-value: 3.78e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTNALRHADRRVRISYRVSLERC-RVDVEDDGPGVPEAQWERLFTPFLRLDDSRTrasGGHGLGLSIVRRIV 419
Cdd:cd16940 14 LFLLLRNLVDNAVRYSPQGSRVEIKLSADDGaVIRVEDNGPGIDEEELEALFERFYRSDGQNY---GGSGLGLSIVKRIV 90
|
90
....*....|....*.
gi 15596355 420 YWHGGRASIGRSETLG 435
Cdd:cd16940 91 ELHGGQIFLGNAQGGG 106
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-444 |
4.44e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 70.89 E-value: 4.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTN---ALRHADRRVRI-SYRVSLERCR---VDVEDDGPGVPEAQWERLFTPFLrlddsrTRASGGHGLGLS 413
Cdd:cd16920 1 IQQVLINLVRNgieAMSEGGCERRElTIRTSPADDRavtISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLS 74
|
90 100 110
....*....|....*....|....*....|.
gi 15596355 414 IVRRIVYWHGGRASIGRSETlGGACFTLAWP 444
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAG-GGATFQFTLP 104
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
220-441 |
4.52e-15 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 76.43 E-value: 4.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 220 LTVQREMV---RAVSHELRTpvaRLRFGLEMIETAETDGARlKYLEGMDNDIQdldklvdEMLTYARLEQGSPpltyqrl 296
Cdd:COG3290 183 LEGVKELAealRAQRHDFRN---HLHTISGLLQLGEYDEAL-EYIDEISEELQ-------ELIDSLLSRIGNP------- 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 297 ELGVLVRQVVEEIAplRREVLVSCEEGALVPEelgswIEAEPRYLHRALQNLLTNALRHA------DRRVRISYRVSLER 370
Cdd:COG3290 245 VLAALLLGKAARAR--ERGIDLTIDIDSDLPD-----LPLSDTDLVTILGNLLDNAIEAVeklpeeERRVELSIRDDGDE 317
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596355 371 CRVDVEDDGPGVPEAQWERLFTP-FLrlddsrTRASGGHGLGLSIVRRIVYWHGGRASIGrSETLGGACFTL 441
Cdd:COG3290 318 LVIEVEDSGPGIPEELLEKIFERgFS------TKLGEGRGLGLALVKQIVEKYGGTIEVE-SEEGEGTVFTV 382
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-441 |
4.72e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 70.56 E-value: 4.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 345 LQNLLTNAL----RHADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLrlddsRTRASG-GHGLGLSIVRRIV 419
Cdd:cd16976 5 LMNLLQNALdamgKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF-----TTKPVGkGTGLGLSISYGIV 79
|
90 100
....*....|....*....|..
gi 15596355 420 YWHGGRASIgRSETLGGACFTL 441
Cdd:cd16976 80 EEHGGRLSV-ANEEGAGARFTF 100
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-444 |
5.57e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 70.69 E-value: 5.57e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTNALRHADRRVRISYRVSLER--CRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTRASGGHGLGLSIVRRI 418
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEEsgARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*..
gi 15596355 419 VYWHGGRASIgrSETLG-GACFTLAWP 444
Cdd:cd16952 81 MSRHDARLLI--ASELGkGSRFTCLFP 105
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
338-445 |
6.75e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 70.53 E-value: 6.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 338 PRYLHRALQNLLTNALRHADRRVRISYRVSL--ERCRVDVEDDGPGVPEAQWERLFTPFLrlddsRTRASG-GHGLGLSI 414
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAhvDQVLIEVEDTGSGIDPEILGRIFDPFF-----TTKPVGeGTGLGLSL 75
|
90 100 110
....*....|....*....|....*....|.
gi 15596355 415 VRRIVYWHGGRASIgRSETLGGACFTLAWPR 445
Cdd:cd16943 76 SYRIIQKHGGTIRV-ASVPGGGTRFTIILPI 105
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-428 |
7.77e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 70.11 E-value: 7.77e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTNALRHA--DRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTraSGGHGLGLSIVRRI 418
Cdd:cd16923 1 LQRVFSNLLSNAIKYSpeNTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
90
....*....|
gi 15596355 419 VYWHGGRASI 428
Cdd:cd16923 79 IELHGGSASA 88
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
171-425 |
1.05e-14 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 75.12 E-value: 1.05e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 171 LEQRLRSLEAAATRIARGSLdtRVEVRGGDSVGRLGAAFNHMAEHIhrlltVQREMVRAVSHELRTPVARLRFGLEMIET 250
Cdd:PRK11073 85 IDGRSHILSLTAQRLPEGMI--LLEMAPMDNQRRLSQEQLQHAQQV-----AARDLVRGLAHEIKNPLGGLRGAAQLLSK 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 251 AETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLTYQRLELgvlVRQVVEEIAP----LRREVLVSceegalV 326
Cdd:PRK11073 158 ALPDPALTEYTKVIIEQADRLRNLVDRLLGPQRPGTHVTESIHKVAER---VVQLVSLELPdnvrLIRDYDPS------L 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 327 PEelgswIEAEPRYLHRALQNLLTNALRHADR-------RVRISYRVSL--ERCR----VDVEDDGPGVPEAQWERLFTP 393
Cdd:PRK11073 229 PE-----LAHDPDQIEQVLLNIVRNALQALGPeggtitlRTRTAFQLTLhgERYRlaarIDIEDNGPGIPPHLQDTLFYP 303
|
250 260 270
....*....|....*....|....*....|..
gi 15596355 394 FLrlddsrTRASGGHGLGLSIVRRIVYWHGGR 425
Cdd:PRK11073 304 MV------SGREGGTGLGLSIARNLIDQHSGK 329
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-441 |
1.63e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 66.33 E-value: 1.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTNALRHADRRVRISYRVSLER--CRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTraSGGH-GLGLSIVRR 417
Cdd:cd16975 5 LSRALINIISNACQYAPEGGTVSISIYDEEeyLYFEIWDNGHGFSEQDLKKALELFYRDDTSRR--SGGHyGMGLYIAKN 82
|
90 100
....*....|....*....|....
gi 15596355 418 IVYWHGGRASIGRSETlGGACFTL 441
Cdd:cd16975 83 LVEKHGGSLIIENSQK-GGAEVTV 105
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
159-448 |
2.14e-13 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 71.59 E-value: 2.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 159 FIGLITYLLVRRLEQRLRSLEAAATRIARGSLdTRVEVRGGDSVGRLGAAFNHMAEHIHRLLTVQREMVRAVSHelrtpv 238
Cdd:COG2972 169 LALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKE------ 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 239 arlrfglemietaetdgARLKYLE------------------GMDNDIQDLDKLVDEMLTYAR--LEQGSPPltyqrlel 298
Cdd:COG2972 242 -----------------AELKALQaqinphflfntlnsirwlAELEDPEEAEEMLEALSKLLRysLSKGDEL-------- 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 299 gVLVRqvvEEIAPLRR-------------EVLVSCEEGALvpeelgswiEAE-PRYLhraLQNLLTNALRHA------DR 358
Cdd:COG2972 297 -VTLE---EELELIKSyleiqklrfgdrlEVEIEIDEELL---------DLLiPKLI---LQPLVENAIEHGiepkegGG 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 359 RVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFlrlddsrTRASGGHGLGLSIVR-RIVYWHGGRASIG-RSETLGG 436
Cdd:COG2972 361 TIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVReRLKLYYGEEYGLEiESEPGEG 433
|
330
....*....|..
gi 15596355 437 ACFTLAWPRKAG 448
Cdd:COG2972 434 TTVTIRIPLEEE 445
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
230-452 |
3.53e-13 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 70.97 E-value: 3.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 230 VSHELRTPVARLR-FGLEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQgsppLTYQRLELGVLVR---QV 305
Cdd:PRK10364 244 VAHEIRNPLSSIKgLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKPTH----LALQAVDLNDLINhslQL 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 306 VEEIAPlRREVLVSCEEGALVPEelgswIEAEPRYLHRALQNLLTNALRHADRRVRISYRVSLERCRVD--VEDDGPGVP 383
Cdd:PRK10364 320 VSQDAN-SREIQLRFTANDTLPE-----IQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKisVTDSGKGIA 393
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596355 384 EAQWERLFTPFLrlddsrTRASGGHGLGLSIVRRIVYWHGGRASIgRSETLGGACFTLAWPRKAGLRDR 452
Cdd:PRK10364 394 ADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQV-ASQEGKGATFTLWLPVNITRRDP 455
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
223-287 |
2.21e-12 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 61.81 E-value: 2.21e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15596355 223 QREMVRAVSHELRTPVARLRFGLEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQG 287
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-428 |
2.23e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 63.69 E-value: 2.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTNALRHAD--RRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTRASGGHGLGLSIVRRI 418
Cdd:cd16947 21 LQRILKNLISNAIKYGSdgKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTITKRL 100
|
90
....*....|
gi 15596355 419 VYWHGGRASI 428
Cdd:cd16947 101 AESMGGSIYV 110
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
223-287 |
2.39e-12 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 61.84 E-value: 2.39e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15596355 223 QREMVRAVSHELRTPVARLRFGLEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQG 287
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-425 |
2.71e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 63.19 E-value: 2.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTNALRHADR-------RVRISYRVSLER------CRVDVEDDGPGVPEAQWERLFTPFLrlddsrTRASGG 407
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGsggeiilRTRTQRQVTLGHprhrlaLRVSVIDNGPGIPPDLQDTIFYPMV------SGRENG 74
|
90
....*....|....*...
gi 15596355 408 HGLGLSIVRRIVYWHGGR 425
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGV 92
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-444 |
3.06e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 62.98 E-value: 3.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTNALRHA-DRRVRISYRVSLE--RCRVDVEDDGPGVPEAQWERLFTPFLRlDDSRTRASGGH-GLGLSIVR 416
Cdd:cd16953 1 LGQVLRNLIGNAISFSpPDTGRITVSAMPTgkMVTISVEDEGPGIPQEKLESIFDRFYT-ERPANEAFGQHsGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 15596355 417 RIVYWHGGRA---SIGRSETLGGACFTLAWP 444
Cdd:cd16953 80 QIIEAHGGISvaeNHNQPGQVIGARFTVQLP 110
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
173-216 |
5.72e-12 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 60.15 E-value: 5.72e-12
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 15596355 173 QRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHMAEHI 216
Cdd:cd06225 2 RPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
347-438 |
1.45e-11 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 66.19 E-value: 1.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 347 NLLTNALRHADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTrasgGHGLGLSIVRRIVYWHGGRA 426
Cdd:PRK10815 385 NVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKI 460
|
90
....*....|..
gi 15596355 427 SIGRSeTLGGAC 438
Cdd:PRK10815 461 SAGDS-PLGGAR 471
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-444 |
3.92e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 59.86 E-value: 3.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 339 RYLHRALQNLLTNALRHADRR--VRISYRVSLE-----RCRVDVEDDGPGVPEAQWERLFTPFLrlddsrTRASGGHGLG 411
Cdd:cd16944 3 TQISQVLTNILKNAAEAIEGRpsDVGEVRIRVEadqdgRIVLIVCDNGKGFPREMRHRATEPYV------TTRPKGTGLG 76
|
90 100 110
....*....|....*....|....*....|...
gi 15596355 412 LSIVRRIVYWHGGRASIGRSETlGGACFTLAWP 444
Cdd:cd16944 77 LAIVKKIMEEHGGRISLSNREA-GGACIRIILP 108
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
169-221 |
8.22e-11 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 57.26 E-value: 8.22e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 15596355 169 RRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHMAEHIHRLLT 221
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-441 |
1.34e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 58.24 E-value: 1.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 337 EPRYLHRALQNLLTNALRH--ADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLddsrTRASGGH---GLG 411
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFspEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSL----PRPHSGQkstGLG 76
|
90 100 110
....*....|....*....|....*....|
gi 15596355 412 LSIVRRIVYWHGGRASIGRSETLGGACFTL 441
Cdd:cd16945 77 LAFVQEVAQLHGGRITLRNRPDGVLAFLTL 106
|
|
| HAMP |
pfam00672 |
HAMP domain; |
166-218 |
1.53e-10 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 56.48 E-value: 1.53e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 15596355 166 LLVRRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHMAEHIHR 218
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
220-283 |
5.55e-10 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 54.91 E-value: 5.55e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15596355 220 LTVQREMVRAVSHELRTPVARLRFGLEMIETAETDGARLK-YLEGMDNDIQDLDKLVDEMLTYAR 283
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQReYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
274-448 |
6.25e-10 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 61.62 E-value: 6.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 274 LVDEMLTYARLEqgspPLTYQRLELGVLVRqvveEIAPLRREVLVSCEEGALVPEELGSWIEAEPRYLHRALQNLLTNAL 353
Cdd:PRK13837 502 IIDQILAFGRKG----ERNTKPFDLSELVT----EIAPLLRVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAA 573
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 354 RHADRRVRIS---YRVSLER--------------CRVDVEDDGPGVPEAQWERLFTPFLrlddsRTRAsGGHGLGLSIVR 416
Cdd:PRK13837 574 QAMDGAGRVDislSRAKLRApkvlshgvlppgryVLLRVSDTGAGIDEAVLPHIFEPFF-----TTRA-GGTGLGLATVH 647
|
170 180 190
....*....|....*....|....*....|..
gi 15596355 417 RIVYWHGGRASIgRSETLGGACFTLAWPRKAG 448
Cdd:PRK13837 648 GIVSAHAGYIDV-QSTVGRGTRFDVYLPPSSK 678
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
1-231 |
1.23e-09 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 60.42 E-value: 1.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 1 MDGRSRARLMNGQVLVKQTAEHAVTVYTQASAAENLVLSGEVQQVSEQLARATVYLLMDELVRYPASEQPYHLARIVRDK 80
Cdd:COG0840 36 LLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 81 RFGFPVHLLQVKELDLDDDQRRRVVEGDTVMALGKDGDSIRIFAGILDTPWVLELGPLFQMNPYPPQLLLLLGALCLSFI 160
Cdd:COG0840 116 LELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALA 195
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596355 161 GLITYLLVRRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHMAEHIHRLLTVQREMVRAVS 231
Cdd:COG0840 196 IILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVRESAEQVA 266
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-444 |
1.49e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 54.99 E-value: 1.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 347 NLLTNAL------RHADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFtpflrlddSR---TRASGGHGLGLSIVRR 417
Cdd:cd16915 7 NLIDNALdalaatGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVF--------ERgvsTKGQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*..
gi 15596355 418 IVYWHGGRASIGrSETLGGACFTLAWP 444
Cdd:cd16915 79 SVERLGGSITVE-SEPGGGTTFSIRIP 104
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
220-435 |
3.16e-09 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 58.97 E-value: 3.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 220 LTVQREMVRAVSHELRTPVARLRFGLEMIETAETDgaRLKYLEGMDNDIQDLDKLVDEMLTYARleqgspPLTYQRLElg 299
Cdd:COG5805 284 LSIAGQLAAGIAHEIRNPLTSIKGFLQLLQPGIED--KEEYFDIMLSELDRIESIISEFLALAK------PQAVNKEK-- 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 300 VLVRQVVEEIAPL------RREVLVSCEEGALVPEelgswIEAEPRYLHRALQNLLTNALRHADRRVRISYRVSLE--RC 371
Cdd:COG5805 354 ENINELIQDVVTLleteaiLHNIQIRLELLDEDPF-----IYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEdnSV 428
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596355 372 RVDVEDDGPGVPEAQWERLFTPFLRLDDSrtrasgGHGLGLSIVRRIVYWHGGRASIGRSETLG 435
Cdd:COG5805 429 IIRVIDEGIGIPEERLKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKG 486
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
230-441 |
4.89e-09 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 58.41 E-value: 4.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 230 VSHELRTPVARLrFGL-EMIETAETDGARLKYLEGMD----------NDIQDLDKLVDEmltyaRLEQGSPPLTyqrlel 298
Cdd:PRK11091 290 ISHELRTPLNGI-VGLsRILLDTELTAEQRKYLKTIHvsaitlgnifNDIIDMDKMERR-----KLQLDNQPID------ 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 299 gvlVRQVVEEIAPLRReVLVSCEEGALVPEELGS---WIEAEPRYLHRALQNLLTNALRHADR---RVRISYRVSlERCR 372
Cdd:PRK11091 358 ---FTDFLADLENLSG-LQAEQKGLRFDLEPLLPlphKVITDGTRLRQILWNLISNAVKFTQQggvTVRVRYEEG-DMLT 432
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596355 373 VDVEDDGPGVPEAQWERLFTPFLRLDDSR-TRASGGHGLGLSIVRRIVYWHGGRASIgrSETLG-GACFTL 441
Cdd:PRK11091 433 FEVEDSGIGIPEDELDKIFAMYYQVKDSHgGKPATGTGIGLAVSKRLAQAMGGDITV--TSEEGkGSCFTL 501
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
223-444 |
6.27e-09 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 58.59 E-value: 6.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 223 QREMVRAVSHELRTPVARLRFGLEMIETA------ETDGARLKYLEGmdndiQDLDKLVDEMLTYARLEQGSPPLTYQRL 296
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSglskeqRVEAISLAYATG-----QSLLGLIGEILDVDKIESGNYQLQPQWV 786
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 297 ELGVLVRQVVEEIAPL--RREVLVSCEegALVPEELgsWIEAEPRYLHRALQNLLTNALRH-ADRRVRISYRV-----SL 368
Cdd:PRK09959 787 DIPTLVQNTCHSFGAIaaSKSIALSCS--STFPDHY--LVKIDPQAFKQVLSNLLSNALKFtTEGAVKITTSLghiddNH 862
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596355 369 ERCRVDVEDDGPGVPEAQWERLFTPFLRldDSRTRASGGHGLGLSIVRRIVYWHGGRASIgRSETLGGACFTLAWP 444
Cdd:PRK09959 863 AVIKMTIMDSGSGLSQEEQQQLFKRYSQ--TSAGRQQTGSGLGLMICKELIKNMQGDLSL-ESHPGIGTTFTITIP 935
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
230-419 |
2.03e-07 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 53.44 E-value: 2.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 230 VSHELRTPVARLRFGLEMIETAE--TDGARLkyLEGMDN----------DIQDLDKLVDEMLtyaRLEQG--SPpltyqr 295
Cdd:PRK10841 454 VSHELRTPLYGIIGNLDLLQTKElpKGVDRL--VTAMNNssslllkiisDILDFSKIESEQL---KIEPRefSP------ 522
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 296 lelgvlvRQVVEEIA----PL--RREVLVSCEEGALVPEELgswiEAEPRYLHRALQNLLTNALRHADR-------RVRI 362
Cdd:PRK10841 523 -------REVINHITanylPLvvKKRLGLYCFIEPDVPVAL----NGDPMRLQQVISNLLSNAIKFTDTgcivlhvRVDG 591
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 15596355 363 SYrvsLErcrVDVEDDGPGVPEAQWERLFTPFLRLDDSRTRASGGHGLGLSIVRRIV 419
Cdd:PRK10841 592 DY---LS---FRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLI 642
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
345-440 |
2.51e-07 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 53.31 E-value: 2.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 345 LQNLLTNALRHADR---RVRISYR------VSLercRVDVEDDGPGVPEAQWERLFTPFLRLDDSRTRASGGHGLGLSIV 415
Cdd:PRK11107 413 ITNLVGNAIKFTESgniDILVELRalsntkVQL---EVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVIT 489
|
90 100
....*....|....*....|....*.
gi 15596355 416 RRIVYWHGGRasIG-RSETLGGACFT 440
Cdd:PRK11107 490 QKLVNEMGGD--ISfHSQPNRGSTFW 513
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
341-447 |
1.06e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 49.62 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTNALRHAD-RRVRISYRVSLERCRVDVEDDGPGVPEAqwerlftpflrlddsrtrASGGHGLGLSIVRRIV 419
Cdd:COG4585 163 LYRIVQEALTNALKHAGaTRVTVTLEVDDGELTLTVRDDGVGFDPE------------------AAPGGGLGLRGMRERA 224
|
90 100
....*....|....*....|....*...
gi 15596355 420 YWHGGRASIGrSETLGGACFTLAWPRKA 447
Cdd:COG4585 225 EALGGTLTIG-SAPGGGTRVRATLPLAA 251
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
159-437 |
1.90e-06 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 50.11 E-value: 1.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 159 FIGLITYLLVRRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHMAEHIHRLLTVQREMVRAVSHELRTPV 238
Cdd:COG2770 224 LALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLL 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 239 ARLRFGLEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLTYQRLELGVLVRQVVEEIAPLRREVLV 318
Cdd:COG2770 304 EALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALA 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 319 SCEEGALVPEELGSWIEAEPRYLHRALQNLLTNALRHADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPFLRLD 398
Cdd:COG2770 384 LEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAE 463
|
250 260 270
....*....|....*....|....*....|....*....
gi 15596355 399 DSRTRASGGHGLGLSIVRRIVYWHGGRASIGRSETLGGA 437
Cdd:COG2770 464 ELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAA 502
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
344-419 |
3.81e-06 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 44.95 E-value: 3.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 344 ALQNLLTNALRHA-----DRRVRISYRVSLERCRVDVEDDGPGvpeaqwerlFTPFLRLDDSRTRASGGHGLGLsiVRRI 418
Cdd:cd16936 4 AVSEAVTNAVRHAyrhdgPGPVRLELDLDPDRLRVEVTDSGPG---------FDPLRPADPDAGLREGGRGLAL--IRAL 72
|
.
gi 15596355 419 V 419
Cdd:cd16936 73 M 73
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
348-419 |
5.19e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 45.67 E-value: 5.19e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596355 348 LLTNALRHA-----DRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLFTPflrlddsrtraSGGHGLGLSIVRRIV 419
Cdd:COG2172 42 AVTNAVRHAyggdpDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYST-----------LAEGGRGLFLIRRLM 107
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-410 |
5.71e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 44.47 E-value: 5.71e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596355 341 LHRALQNLLTNALRHAD-RRVRISYRVSLERCRVDVEDDGPGVpeaqwerlftpflrlDDSRTRASGGHGL 410
Cdd:cd16917 1 LYRIVQEALTNALKHAGaSRVRVTLSYTADELTLTVVDDGVGF---------------DGPAPPGGGGFGL 56
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
348-447 |
4.70e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 45.67 E-value: 4.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 348 LLTNALRHA-----DRRVRISYRVSLERCRVDVEDDGPGVPEaqwerlftpflrlddsRTRASGGHGLGLSIVRRIVYWH 422
Cdd:COG3920 407 LVTNALKHAflsgeGGRIRVSWRREDGRLRLTVSDNGVGLPE----------------DVDPPARKGLGLRLIRALVRQL 470
|
90 100
....*....|....*....|....*
gi 15596355 423 GGRASIGRSEtlgGACFTLAWPRKA 447
Cdd:COG3920 471 GGTLELDRPE---GTRVRITFPLAE 492
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
159-436 |
6.25e-05 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 45.26 E-value: 6.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 159 FIGLITYLLVRRLEQRLRSLEAAATRIARGSLDTRVEVRGGDSVGRLGAAFNHMAEHIHRL-------LTVQREMVRAVS 231
Cdd:COG3850 130 LALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELyaeleeeEELEAELELLAL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 232 HELRTPVARLRFGLEMIETAETDGARLKYLEGMDNDIQDLDKLVDEMLTYARLEQGSPPLTYQRLELGVLVRQVVEEIAP 311
Cdd:COG3850 210 LDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALL 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 312 LRREVLVSCEEGALVPEELGSWIEAEPRYLHRALQNLLTNALRHADRRVRISYRVSLERCRVDVEDDGPGVPEAQWERLF 391
Cdd:COG3850 290 LELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAA 369
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 15596355 392 TPFLRLDDSRTRASGGHGLGLSIVRRIVYWHGGRASIGRSETLGG 436
Cdd:COG3850 370 GLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEG 414
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
341-428 |
3.76e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 40.06 E-value: 3.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 341 LHRALQNLLTNA---------------LRHADRRVRISYR-------VSLErcrvdVEDDGPGVPEAQWERLFTPFLRld 398
Cdd:cd16919 1 LELAILNLAVNArdampeggrltietsNQRVDADYALNYRdlipgnyVCLE-----VSDTGSGMPAEVLRRAFEPFFT-- 73
|
90 100 110
....*....|....*....|....*....|.
gi 15596355 399 dsrTRASG-GHGLGLSIVRRIVYWHGGRASI 428
Cdd:cd16919 74 ---TKEVGkGTGLGLSMVYGFVKQSGGHLRI 101
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-419 |
9.43e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 39.32 E-value: 9.43e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596355 348 LLTNALRHA--DR---RVRISYRVSLERCRVDVEDDGPGVPEAQwerlftpflrldDSRTRASgghgLGLSIVRRIV 419
Cdd:cd16951 47 LLQNALKHAfsDReggTITIRSVVDGDYLRITVIDDGVGLPQDE------------DWPNKGS----LGLQIVRSLV 107
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
314-425 |
1.03e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 39.19 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 314 REVLVSCEEGALVPEELgsWIEaepryLHRALQNLLTNALRHADR-----RVRISYRVSLERCRVDVEDDGPGVPEAQWE 388
Cdd:pfam13581 12 RRVLEAVLRRAGLPEEL--LDE-----VELAVGEACTNAVEHAYRegpegPVEVRLTSDGGGLVVTVADSGPPFDPLTLP 84
|
90 100 110
....*....|....*....|....*....|....*....
gi 15596355 389 rlftPFLRLDDSRTRASGGHGLGL--SIVRRIVYWHGGR 425
Cdd:pfam13581 85 ----PPDLEEPDEDRKEGGRGLALirGLMDDVEYTRGGE 119
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-414 |
7.87e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 35.88 E-value: 7.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596355 344 ALQNLLTNALRHADR------RVRISYRVSLERCRVDVEDDGPGV-PEAQWERLFTPF----LRLDDSRTRASGGHGLGL 412
Cdd:cd16956 5 TLQPIVENAVKHGLSglldggRVEITARLDGQHLLLEVEDNGGGMdPDTLARILIRSSnglgLNLVDKRLRQAFGNDYGL 84
|
..
gi 15596355 413 SI 414
Cdd:cd16956 85 DI 86
|
|
| UhpB |
COG3851 |
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ... |
341-383 |
8.85e-03 |
|
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];
Pssm-ID: 443060 [Multi-domain] Cd Length: 493 Bit Score: 38.45 E-value: 8.85e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 15596355 341 LHRALQNLLTNALRHAD-RRVRISYRVSLERCRVDVEDDGPGVP 383
Cdd:COG3851 401 LYRLVQEALTNILKHAEaSQIRISLSQDKRLLSLEIRDDGIGLP 444
|
|
| |
