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Conserved domains on  [gi|15596454|ref|NP_249948|]
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amino acid ABC transporter permease [Pseudomonas aeruginosa PAO1]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-212 1.14e-58

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 183.74  E-value: 1.14e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   1 MFTTSLTANDLLFLLQGAWTTLAITAMAMLIGTLLGVVFGLLRALLPRA-SLPLAALLDVFRSVPLLIQFVLLNSFKSIL 79
Cdd:COG0765   2 FFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVlRWLATAYVEFFRGTPLLVQLFFIYFGLPLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  80 GLDWSAFAVACLVLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVMKDTS 159
Cdd:COG0765  82 GIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTS 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 15596454 160 LVLWIGIVELLRASQTIVTRIQEPLFVLCIAGLVYYLMSWVVARLGARLERRW 212
Cdd:COG0765 162 LVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRL 214
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-212 1.14e-58

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 183.74  E-value: 1.14e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   1 MFTTSLTANDLLFLLQGAWTTLAITAMAMLIGTLLGVVFGLLRALLPRA-SLPLAALLDVFRSVPLLIQFVLLNSFKSIL 79
Cdd:COG0765   2 FFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVlRWLATAYVEFFRGTPLLVQLFFIYFGLPLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  80 GLDWSAFAVACLVLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVMKDTS 159
Cdd:COG0765  82 GIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTS 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 15596454 160 LVLWIGIVELLRASQTIVTRIQEPLFVLCIAGLVYYLMSWVVARLGARLERRW 212
Cdd:COG0765 162 LVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRL 214
PRK15100 PRK15100
cystine ABC transporter permease;
13-211 4.71e-26

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 100.21  E-value: 4.71e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   13 FLLQGAWTTLAITAMAMLIGTLLGVVFGLLR-ALLPRASLPLAALLDVFRSVPLLIQFVLLNSFKSILGLDWSAFAVACL 91
Cdd:PRK15100  14 FLLKGAGYTLQLSIGGMFFGLLLGFILALMRlSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDPIPAAMI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   92 VLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVMKDTSLVLWIGIVELLR 171
Cdd:PRK15100  94 GLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFR 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 15596454  172 ASQTIVTRIQEPLFVLCIAGLVYYLMSWVVARLGARLERR 211
Cdd:PRK15100 174 QAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQ 213
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 18-197 1.23e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 61.14  E-value: 1.23e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  18 AWTTLAITAMAMLIGTLLGVVFGLLRALL-PRASLPLAALLDVFRSVPLLIQ---FVLLNSFKSILGLDWSAFAVACLVL 93
Cdd:cd06261   1 LLNTLLLALIATLLALVLGLLLGIILARKrGKLDRLLRRIIDLLLSLPSLVLgllLVLLFGVLLGWGILPGLGLPALILA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  94 GVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVMKDTSLVLWIGIVELLRAS 173
Cdd:cd06261  81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                       170       180
                ....*....|....*....|....
gi 15596454 174 QTIVTRIQEPLFVLCIAGLVYYLM 197
Cdd:cd06261 161 TGLLLIFAILFPGDLGVAAAVALI 184
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 13-107 5.79e-10

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 54.46  E-value: 5.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454    13 FLLQGAWTTLAITAMAMLIGTLLGVVFGLLRALLPR-ASLPLAALLDVFRSVPLLIQFVLLNSFKSILGLDWSAFAVACL 91
Cdd:TIGR01726   4 FLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRpLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTAAVI 83

                          90
                  ....*....|....*.
gi 15596454    92 VLGVYAAAYCAEVVRG 107
Cdd:TIGR01726  84 ALTLFYGAYLAEIFRG 99
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 36-165 3.60e-08

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 51.15  E-value: 3.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454    36 GVVFGLLRALLPRASL--PLAALLDVFRSVPLLIQFVLLNSFKSILGLDWSAFAVACLVLgVYAAAYCAEVVRGGVLSVP 113
Cdd:pfam00528   1 GIPLGIIAALRRGRRLdrLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILAL-LGWAGYARLIRRAALRSLP 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15596454   114 PSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVMKDTSLVLWIG 165
Cdd:pfam00528  80 SDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLG 131
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-212 1.14e-58

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 183.74  E-value: 1.14e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   1 MFTTSLTANDLLFLLQGAWTTLAITAMAMLIGTLLGVVFGLLRALLPRA-SLPLAALLDVFRSVPLLIQFVLLNSFKSIL 79
Cdd:COG0765   2 FFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVlRWLATAYVEFFRGTPLLVQLFFIYFGLPLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  80 GLDWSAFAVACLVLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVMKDTS 159
Cdd:COG0765  82 GIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTS 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 15596454 160 LVLWIGIVELLRASQTIVTRIQEPLFVLCIAGLVYYLMSWVVARLGARLERRW 212
Cdd:COG0765 162 LVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRL 214
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 11-212 1.57e-33

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 119.81  E-value: 1.57e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  11 LLFLLQGAWTTLAITAMAMLIGTLLGVVFGLLRALLPR-ASLPLAALLDVFRSVPLLIQFVL----LNSFKSI--LGLDW 83
Cdd:COG4160  10 LPLLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRlLRWPARGYIYVFRGTPLLVQLFLiyygLGQFEWVreSWLWP 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  84 ---SAFAVACLVLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVMKDTSL 160
Cdd:COG4160  90 llrDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEVILMLKATAL 169

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 15596454 161 VLWIGIVELLRASQTIVTRIQEPLFVLCIAGLVYYLMSWVVARLGARLERRW 212
Cdd:COG4160 170 ASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRL 221
PRK15100 PRK15100
cystine ABC transporter permease;
13-211 4.71e-26

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 100.21  E-value: 4.71e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   13 FLLQGAWTTLAITAMAMLIGTLLGVVFGLLR-ALLPRASLPLAALLDVFRSVPLLIQFVLLNSFKSILGLDWSAFAVACL 91
Cdd:PRK15100  14 FLLKGAGYTLQLSIGGMFFGLLLGFILALMRlSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDPIPAAMI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   92 VLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVMKDTSLVLWIGIVELLR 171
Cdd:PRK15100  94 GLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFR 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 15596454  172 ASQTIVTRIQEPLFVLCIAGLVYYLMSWVVARLGARLERR 211
Cdd:PRK15100 174 QAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQ 213
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 2-211 3.49e-24

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 95.12  E-value: 3.49e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454    2 FTTSLTANDLLFLLQGAWTTLAITAMAMLIGTLLGVVFGLLRALLPRASLPLA-ALLDVFRSVPLLIQ--FVLLNSFKSI 78
Cdd:PRK09494   3 FDWSAIWPAIPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIAlVFIELIRGTPIVVQvmFIYFALPMAF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   79 LGLDWSAFAVACLVLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVMKDT 158
Cdd:PRK09494  83 NDLRIDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDT 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 15596454  159 SLVLWIGIVELLRASQTIVTRIQEPLFVLCIAGLVYYLMSWVVARLGARLERR 211
Cdd:PRK09494 163 SLFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERR 215
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
9-211 3.92e-21

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 87.43  E-value: 3.92e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454    9 NDLLFLLQGAWTTLAITAMAMLIGTLLGVVFGLLRALLPRA-SLPLAALLDVFRSVP-----LLIQF------------- 69
Cdd:PRK11123   2 NEFFPLASAAGMTVGLAVCALIVGLALAMLFAVWESAKWRPvAWPGTALVTLLRGLPeilvvLFIYFgssqllltlsdgf 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   70 -VLLNSFKSILGLDWSAFAVACLVLGVYA-----AAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVA 143
Cdd:PRK11123  82 tLNLGFVQIPVQMDIENFEVSPFLCGVIAlsllyAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHA 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596454  144 FPGWVNLTLSVMKDTSLVLWIGIVELLRASQTIVTRIQEPLFVLCIAGLVYYLMSWVVARLGARLERR 211
Cdd:PRK11123 162 LPGLGNQWLVLLKDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLVITLISQYILKRIELR 229
artM PRK11122
arginine ABC transporter permease ArtM;
11-211 8.82e-15

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 70.37  E-value: 8.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   11 LLFLLQGAWTTLAITAMAMLIGTLLGVVFGLLRAL-LPRASLPLAALLDVFRSVPLLIQFVLL----NSFKSILGLDW-- 83
Cdd:PRK11122   5 LPELLKGLHTSLTLTVASLLVALVLALIFTIILTLkTPVLVWLVRGYITLFTGTPLLVQIFLIyygpGQFPWLQEYPWlw 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   84 ----SAFAVACLVLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFhIVLPMAARVAFPGWVNLTLSVMKDTS 159
Cdd:PRK11122  85 hllsQPWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTLR-ILLPYAFKRALSSYSNEVVLVFKSTS 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 15596454  160 LVLWIGIVELLRASQTIVTRIQEPLfVLCIAGLVYYLMSWVVARLGARLERR 211
Cdd:PRK11122 164 LAYTITLMDVMGYSQLLYGRTYDVM-VFGAAGIIYLVVNGLLTLLMRLIERK 214
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
2-211 1.39e-14

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 69.86  E-value: 1.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454    2 FTTSLTANDLLFLLQGAWTTLAITAMAMLIGTLLGVVFGLLRALLPRASLPLAAL-LDVFRSVPL---LIQFVLL--NSF 75
Cdd:PRK15107   4 FDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAyVNVFRSIPLvmvLLWFYLIvpGFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   76 KSILGLDWSA---FAVACLVLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTL 152
Cdd:PRK15107  84 QNVLGLSPKTdirLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGI 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 15596454  153 SVMKDTSLVLWIGIVELLRASQTIVTRIQEPLFVLCIAGLVYYLMSWVVARLGARLERR 211
Cdd:PRK15107 164 VLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKR 222
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 18-197 1.23e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 61.14  E-value: 1.23e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  18 AWTTLAITAMAMLIGTLLGVVFGLLRALL-PRASLPLAALLDVFRSVPLLIQ---FVLLNSFKSILGLDWSAFAVACLVL 93
Cdd:cd06261   1 LLNTLLLALIATLLALVLGLLLGIILARKrGKLDRLLRRIIDLLLSLPSLVLgllLVLLFGVLLGWGILPGLGLPALILA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  94 GVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVMKDTSLVLWIGIVELLRAS 173
Cdd:cd06261  81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                       170       180
                ....*....|....*....|....
gi 15596454 174 QTIVTRIQEPLFVLCIAGLVYYLM 197
Cdd:cd06261 161 TGLLLIFAILFPGDLGVAAAVALI 184
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
14-214 4.69e-10

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 57.11  E-value: 4.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   14 LLQGAWTTLAITAMAMLIGTLLGVVFGLLRALLPRA-SLPLAALLDVFRSVPLLIQFVL--------LNSFKSILGL--- 81
Cdd:PRK15135   9 ILQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLlGLIFEGYTTLIRGVPDLVLMLLifyglqiaLNSVTEALGVgqi 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   82 DWSAFAVACLVLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVMKDTSLV 161
Cdd:PRK15135  89 DIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALV 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 15596454  162 LWIGIVELLRASQTIVTRIQEPLFVLCIAGLVYYLMSWVVARLGARLERRWQQ 214
Cdd:PRK15135 169 SLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLWLERRYSV 221
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 13-107 5.79e-10

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 54.46  E-value: 5.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454    13 FLLQGAWTTLAITAMAMLIGTLLGVVFGLLRALLPR-ASLPLAALLDVFRSVPLLIQFVLLNSFKSILGLDWSAFAVACL 91
Cdd:TIGR01726   4 FLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRpLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTAAVI 83

                          90
                  ....*....|....*.
gi 15596454    92 VLGVYAAAYCAEVVRG 107
Cdd:TIGR01726  84 ALTLFYGAYLAEIFRG 99
PRK15069 PRK15069
histidine ABC transporter permease HisM;
20-212 3.26e-09

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 55.06  E-value: 3.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   20 TTLAITA----MAMLIGTLLGVVFGLLRALLPRA-SLPLAALLDVFRSVPLLIQFVL----LNSFKSILGLDW------S 84
Cdd:PRK15069  21 TGLAITLwllvASVVIGFVLAVPLAIARVSSNKWiRFPVWLYTYVFRGTPLYVQLLVfytgMYSLEIVRGTDLldaffrS 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   85 AFAVACLVLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVMKDTSLVLWI 164
Cdd:PRK15069 101 GLNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTA 180

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 15596454  165 GIVELLRASQTIVTRIQEPLFVLCIAGLVYYLMSWVVARLGARLERRW 212
Cdd:PRK15069 181 TVPDILKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERRW 228
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 14-213 1.07e-08

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 53.61  E-value: 1.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  14 LLQGAWTTLAITAMAMLIGTLLGVVFGLLRALLPRASLPLAALLDVFRSVPLLIQFVLLNsfkSILGLDWSAfAVACLVL 93
Cdd:COG0600  59 LWEHLLASLLRVLLGFALAALLGVPLGLLLGLSRLLRRLLDPLLVFLRPIPPLALAPLLI---LWFGIGEAS-KIFVIFL 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  94 GVYAAAYCAevVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGW-VNLTLSvmkdtslvlWIGIV--ELL 170
Cdd:COG0600 135 GAFFPILLN--TAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGLrIALGLA---------WIGLVvaELL 203

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 15596454 171 RASQTIVTRIQE---------PLFVLCIAGLVYYLMSWVVARLGARLeRRWQ 213
Cdd:COG0600 204 GASSGLGYLILDarqlldtdlVFAAILVIGLLGLLLDLLLRLLERRL-LRWR 254
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 36-165 3.60e-08

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 51.15  E-value: 3.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454    36 GVVFGLLRALLPRASL--PLAALLDVFRSVPLLIQFVLLNSFKSILGLDWSAFAVACLVLgVYAAAYCAEVVRGGVLSVP 113
Cdd:pfam00528   1 GIPLGIIAALRRGRRLdrLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILAL-LGWAGYARLIRRAALRSLP 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15596454   114 PSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVMKDTSLVLWIG 165
Cdd:pfam00528  80 SDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLG 131
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
11-149 2.29e-07

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 49.35  E-value: 2.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   11 LLFLLQGAWTTLAITAMAMLIGTLLGVVFGLLRALL--------PRASLPLAALLDVFRSVPLLIQFVLLNSFKSILGLD 82
Cdd:PRK10782   6 MWLLVRGVWETLAMTFVSGFFGFVIGLPVGVLLYVTrpgqiianAKLYRTLSALVNIFRSIPFIILLVWMIPFTRVIVGT 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596454   83 WSAFAVACLVLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMaarvAFPGWVN 149
Cdd:PRK10782  86 SIGLQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPE----ALPGLVN 148
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 14-142 2.85e-07

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 49.28  E-value: 2.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  14 LLQGAWTTLAITAMAMLIGTLLGVVFGLLRALLPRASLPLAALLDVFRSVPLLIQFVLLnsfKSILGLDWSAfAVACLVL 93
Cdd:COG1174  16 ILALLLEHLLLVLLALLIALLIAVPLGILITRRRRLAGLVLGVANILQTIPSLALLALL---IPLLGIGPAP-AIIALVL 91

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15596454  94 gvYAAAycaEVVRG---GVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARV 142
Cdd:COG1174  92 --YALL---PILRNtytGLRSVDPAVVEAARGMGMTPWQRLWRVELPLALPV 138
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
14-162 3.16e-07

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 50.16  E-value: 3.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  14 LLQGAWTTLAITAMAMLIGTLLGVVFGLLRALLPRaslPLAALLDVFRSVPLLIQ-------FVLLNSFKSILGLDWSAF 86
Cdd:COG1178 336 LLRALLNSLLLALLAALLAVLLALLLAYLVRRRRG---RLARLLDRLAMLPYAVPgivlglgLLLLFNRPLPLLLYGTLA 412

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596454  87 AVAcLVLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVMKDTSLVL 162
Cdd:COG1178 413 ILV-LAYVVRFLPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATL 487
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 14-154 1.34e-05

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 44.72  E-value: 1.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  14 LLQGAWTTLAITAMAMLIGTLLGVVFGLLRALLP-RASLPLAALLDVFRSVPLLIqFVLLnsFKSILGldwSAFAVACLV 92
Cdd:COG1173  74 LLYGARISLLVGLLAVLIALVIGVLLGLLAGYFGgWVDAVLMRLVDVLLAFPSLL-LAIA--LVAVLG---PGLLNVILA 147

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596454  93 LGVYAAAYCAEVVRGGVLSVppsvRR-----AARSLGLSYRQDLFHIVLPMAARVAFpgwVNLTLSV 154
Cdd:COG1173 148 LGLTGWPGYARLVRAQVLSL----REreyveAARALGASPLRIIFRHILPNVLPPLI---VQATLGI 207
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 14-140 1.41e-04

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 41.64  E-value: 1.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  14 LLQGAWTTLAITAMAMLIGTLLGVVFGLLralLPRASLPLAALLDVFRSVPLLIQFVL----LNSFKSILGLDWSAFAVA 89
Cdd:COG1177  59 LLDALLNSLLIALLSTLLATVLGTPAALA---LARYRFRGRRLLLALLLLPLVVPGIVlgvaLLLLFSALGLSGGLWGLI 135

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15596454  90 cLVLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAA 140
Cdd:COG1177 136 -LAHVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIA 185
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
14-166 3.70e-03

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 37.83  E-value: 3.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  14 LLQGAWTTLAITAMAMLIGTLLGVVFGLLRAllpRASLPLAALLDVFRSVPLLI-QFVLLNSFKSILG------------ 80
Cdd:COG1178  52 LWRALGNTLLLALLVTLLSLLLGVPLAWLLA---RTDFPGRRLLRWLLLLPLALpPYVVALAWIALFGpngllntllral 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454  81 LDWSAFAV-----ACLVLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGWVNLTLSVM 155
Cdd:COG1178 129 FGLEPPDIyglggIILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCL 208

                       170
                ....*....|.
gi 15596454 156 KDTSLVLWIGI 166
Cdd:COG1178 209 ADFGTPLVLGG 219
PRK10952 PRK10952
proline/glycine betaine ABC transporter permease ProW;
17-152 7.71e-03

proline/glycine betaine ABC transporter permease ProW;


Pssm-ID: 236805  Cd Length: 355  Bit Score: 36.61  E-value: 7.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596454   17 GAWT----TLAITAMAMLIGTLLGVVFGLLRALLPRASLPLAALLDVFRSVP---LLIQFVLLNSFKSILGLdwsafava 89
Cdd:PRK10952 141 GAWSqamvTLALVLTALLFCIVIGLPLGIWLARSPRAAKIIRPLLDAMQTTPafvYLVPIVMLFGIGNVPGV-------- 212

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15596454   90 cLVLGVYAAAYCAEVVRGGVLSVPPSVRRAARSLGLSYRQDLFHIVLPMAARVAFPGwVNLTL 152
Cdd:PRK10952 213 -VVTIIFALPPIVRLTILGINQVPADLIEASRSFGASPRQMLFKVQLPLAMPTIMAG-VNQTL 273
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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