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Conserved domains on  [gi|15596465|ref|NP_249959|]
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4-hydroxyproline 2-epimerase [Pseudomonas aeruginosa PAO1]

Protein Classification

4-hydroxyproline epimerase; proline racemase family protein( domain architecture ID 1905033)

4-hydroxyproline epimerase catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp)| proline racemase family protein similar to trans-3-hydroxy-L-proline (t3LHyp) dehydratase (aka 4-hydroxyproline 2-epimerase) that catalyzes the dehydration of t3LHyp to delta(1)-pyrroline-2-carboxylate (Pyr2C), and the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pro_racemase super family cl42407
Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which ...
 1-312 0e+00

Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Swiss:Q9NCP4 a sequence with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.


The actual alignment was detected with superfamily member PRK13970:

Pssm-ID: 478179  Cd Length: 311  Bit Score: 509.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465    1 MQRIRIIDSHTGGEPTRLVIGGFPDLGQGDMAERRRLLGERHDAWRAACILEPRGSDVLVGALLCAPVDPEACAGVIFFN 80
Cdd:PRK13970   2 MKRIQIIDSHTGGEPTRLVVSGFPSLGGGTMAERRDVLAREHDRYRTACILEPRGSDVLVGALLCEPVSPDAAAGVIFFN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465   81 NSGYLGMCGHGTIGLVASLAHLGRIGPGVHRIETPVGEVEATLHEDGSVSVRNVPAYRYRRQVSVEVPGIGRVSGDIAWG 160
Cdd:PRK13970  82 NSGYLGMCGHGTIGVVRTLHHMGRIGPGVHRIETPVGTVEATLHDDLSVSVRNVLAYRHAKDVVVDVPGYGPVKGDIAWG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465  161 GNWFFLVAGHGQRLAGDNLDALTAYTVAVQQALDDQDIRGEDGGAIDHIELFADDPHADSRNFVLCPGKAYDRSPCGTGT 240
Cdd:PRK13970 162 GNWFFLISDHGQRVAGDNVAALTAYASAVRAGLERAGITGANGGEIDHIELFADDPEHDSRSFVLCPGHAYDRSPCGTGT 241

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596465  241 SAKLACLAADGKLLPGQPWRQASVIGSQFEGRYEWLDGQpggpIVPTIRGRAHVSAEATLLLADDDPFAWGI 312
Cdd:PRK13970 242 SAKLACLAADGKLAPGVVWRQASVIGSVFSASYAAAEGG----IVPTIRGSAHLSAEATLLIEDDDPFGWGI 309
 
Name Accession Description Interval E-value
PRK13970 PRK13970
4-hydroxyproline epimerase;
1-312 0e+00

4-hydroxyproline epimerase;


Pssm-ID: 172473  Cd Length: 311  Bit Score: 509.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465    1 MQRIRIIDSHTGGEPTRLVIGGFPDLGQGDMAERRRLLGERHDAWRAACILEPRGSDVLVGALLCAPVDPEACAGVIFFN 80
Cdd:PRK13970   2 MKRIQIIDSHTGGEPTRLVVSGFPSLGGGTMAERRDVLAREHDRYRTACILEPRGSDVLVGALLCEPVSPDAAAGVIFFN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465   81 NSGYLGMCGHGTIGLVASLAHLGRIGPGVHRIETPVGEVEATLHEDGSVSVRNVPAYRYRRQVSVEVPGIGRVSGDIAWG 160
Cdd:PRK13970  82 NSGYLGMCGHGTIGVVRTLHHMGRIGPGVHRIETPVGTVEATLHDDLSVSVRNVLAYRHAKDVVVDVPGYGPVKGDIAWG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465  161 GNWFFLVAGHGQRLAGDNLDALTAYTVAVQQALDDQDIRGEDGGAIDHIELFADDPHADSRNFVLCPGKAYDRSPCGTGT 240
Cdd:PRK13970 162 GNWFFLISDHGQRVAGDNVAALTAYASAVRAGLERAGITGANGGEIDHIELFADDPEHDSRSFVLCPGHAYDRSPCGTGT 241

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596465  241 SAKLACLAADGKLLPGQPWRQASVIGSQFEGRYEWLDGQpggpIVPTIRGRAHVSAEATLLLADDDPFAWGI 312
Cdd:PRK13970 242 SAKLACLAADGKLAPGVVWRQASVIGSVFSASYAAAEGG----IVPTIRGSAHLSAEATLLIEDDDPFGWGI 309
Pro_racemase pfam05544
Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which ...
 6-313 6.85e-153

Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Swiss:Q9NCP4 a sequence with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.


Pssm-ID: 398923  Cd Length: 325  Bit Score: 430.95  E-value: 6.85e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465     6 IIDSHTGGEPTRLVIGGFPDLGQGDMAERRRLLGERHDAWRAACILEPRGSDVLVGALLCAPVDPEACAGVIFFNNSGYL 85
Cdd:pfam05544   1 VVDSHTEGEPGRVVVGGVPPLPGATMAEKRRYFARDHDHLRRFLMFEPRGHDMMSGALLVPPKRPDADAGVIFMEPSGYL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465    86 GMCGHGTIGLVASLAHLGRIGPGVHR----IETPVGEVEATLHEDG----SVSVRNVPAYRYRRQVSVEVPGIGRVSGDI 157
Cdd:pfam05544  81 PMCGHNTIGVVTVLLETGIVPPQEPEtrlnLETPAGLVEARAECRDgkveRVSLRNVPSFVYALDVEVEVPGLGRVRVDI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465   158 AWGGNWFFLVAGH--GQRLAGDNLDALTAYTVAVQQALDDQ----DIRGEDGGAIDHIELFADDPH--ADSRNFVLCPGK 229
Cdd:pfam05544 161 AYGGNFYAIVDAEqlGFDIEPAEARELVAAGEKIRDALNEQlkvvHPENPDIRGVSHVQLTGPPTRaeAHARNAVIIGPG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465   230 AYDRSPCGTGTSAKLACLAADGKLLPGQPWRQASVIGSQFEGRYEWLDGQPGGP-IVPTIRGRAHVSAEATLLLADDDPF 308
Cdd:pfam05544 241 AIDRSPCGTGTSARMAQLHAKGKLKVGETFVHESIIGSEFEGRVEGETEVGGRPaIVPSISGRAWITGTNQLLLDPSDPF 320


                  ....*
gi 15596465   309 AWGIR 313
Cdd:pfam05544 321 AHGFR 325
PrdF COG3938
Proline racemase/hydroxyproline epimerase [Amino acid transport and metabolism];
4-311 1.95e-105

Proline racemase/hydroxyproline epimerase [Amino acid transport and metabolism];


Pssm-ID: 443139  Cd Length: 335  Bit Score: 310.88  E-value: 1.95e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465   4 IRIIDSHTGGEPTRLVIGGFPDLGQGDMAERRRLLGERHDAWRAACILEPRGSDVLVGALLCAPVDPEACAGVIFFNNSG 83
Cdd:COG3938   7 ITTIDAHTEGEPTRVVTGGVPPLPGNTMLEKRRYFAENYDWLRRLLMFEPRGHADMSGALLVPPTRPDADFGVIFMETSG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465  84 YLGMCGHGTIGLVASLAHLGRIGP----GVHRIETPVGEVEATLH-EDG---SVSVRNVPAYRYRRQVSVEVPGIGRVSG 155
Cdd:COG3938  87 YLPMCGHGTIGVATVLLETGLVPMtepvTEVVLDTPAGLVRARAEvEDGkveSVTFENVPSFVYALDVEVEVPGLGTVTV 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465 156 DIAWGGNWFFLV--AGHGQRLAGDNLDALTAYTVAVQQALDDQ---------DIRGedggaIDHIELFAD--DPHADSRN 222
Cdd:COG3938 167 DIAYGGNFYAIVdaQQLGLDLEPENARELIRLGLEIRDAANEQlevvhpenpDING-----VSHVEFTGPptDPDADARN 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465 223 FVLCPGKAYDRSPCGTGTSAKLACLAADGKLLPGQPWRQASVIGSQFEGRYE---WLDGQPGgpIVPTIRGRAHVSAEAT 299
Cdd:COG3938 242 AVVFGPGAIDRSPCGTGTSARMALLHARGELKVGETFVHESIIGSRFTGRILeetTVGGYPA--IIPEITGRAWITGFNQ 319

                       330
                ....*....|..
gi 15596465 300 LLLADDDPFAWG 311
Cdd:COG3938 320 FVLDPDDPLPEG 331
 
Name Accession Description Interval E-value
PRK13970 PRK13970
4-hydroxyproline epimerase;
1-312 0e+00

4-hydroxyproline epimerase;


Pssm-ID: 172473  Cd Length: 311  Bit Score: 509.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465    1 MQRIRIIDSHTGGEPTRLVIGGFPDLGQGDMAERRRLLGERHDAWRAACILEPRGSDVLVGALLCAPVDPEACAGVIFFN 80
Cdd:PRK13970   2 MKRIQIIDSHTGGEPTRLVVSGFPSLGGGTMAERRDVLAREHDRYRTACILEPRGSDVLVGALLCEPVSPDAAAGVIFFN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465   81 NSGYLGMCGHGTIGLVASLAHLGRIGPGVHRIETPVGEVEATLHEDGSVSVRNVPAYRYRRQVSVEVPGIGRVSGDIAWG 160
Cdd:PRK13970  82 NSGYLGMCGHGTIGVVRTLHHMGRIGPGVHRIETPVGTVEATLHDDLSVSVRNVLAYRHAKDVVVDVPGYGPVKGDIAWG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465  161 GNWFFLVAGHGQRLAGDNLDALTAYTVAVQQALDDQDIRGEDGGAIDHIELFADDPHADSRNFVLCPGKAYDRSPCGTGT 240
Cdd:PRK13970 162 GNWFFLISDHGQRVAGDNVAALTAYASAVRAGLERAGITGANGGEIDHIELFADDPEHDSRSFVLCPGHAYDRSPCGTGT 241

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596465  241 SAKLACLAADGKLLPGQPWRQASVIGSQFEGRYEWLDGQpggpIVPTIRGRAHVSAEATLLLADDDPFAWGI 312
Cdd:PRK13970 242 SAKLACLAADGKLAPGVVWRQASVIGSVFSASYAAAEGG----IVPTIRGSAHLSAEATLLIEDDDPFGWGI 309
Pro_racemase pfam05544
Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which ...
 6-313 6.85e-153

Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Swiss:Q9NCP4 a sequence with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.


Pssm-ID: 398923  Cd Length: 325  Bit Score: 430.95  E-value: 6.85e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465     6 IIDSHTGGEPTRLVIGGFPDLGQGDMAERRRLLGERHDAWRAACILEPRGSDVLVGALLCAPVDPEACAGVIFFNNSGYL 85
Cdd:pfam05544   1 VVDSHTEGEPGRVVVGGVPPLPGATMAEKRRYFARDHDHLRRFLMFEPRGHDMMSGALLVPPKRPDADAGVIFMEPSGYL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465    86 GMCGHGTIGLVASLAHLGRIGPGVHR----IETPVGEVEATLHEDG----SVSVRNVPAYRYRRQVSVEVPGIGRVSGDI 157
Cdd:pfam05544  81 PMCGHNTIGVVTVLLETGIVPPQEPEtrlnLETPAGLVEARAECRDgkveRVSLRNVPSFVYALDVEVEVPGLGRVRVDI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465   158 AWGGNWFFLVAGH--GQRLAGDNLDALTAYTVAVQQALDDQ----DIRGEDGGAIDHIELFADDPH--ADSRNFVLCPGK 229
Cdd:pfam05544 161 AYGGNFYAIVDAEqlGFDIEPAEARELVAAGEKIRDALNEQlkvvHPENPDIRGVSHVQLTGPPTRaeAHARNAVIIGPG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465   230 AYDRSPCGTGTSAKLACLAADGKLLPGQPWRQASVIGSQFEGRYEWLDGQPGGP-IVPTIRGRAHVSAEATLLLADDDPF 308
Cdd:pfam05544 241 AIDRSPCGTGTSARMAQLHAKGKLKVGETFVHESIIGSEFEGRVEGETEVGGRPaIVPSISGRAWITGTNQLLLDPSDPF 320


                  ....*
gi 15596465   309 AWGIR 313
Cdd:pfam05544 321 AHGFR 325
PrdF COG3938
Proline racemase/hydroxyproline epimerase [Amino acid transport and metabolism];
4-311 1.95e-105

Proline racemase/hydroxyproline epimerase [Amino acid transport and metabolism];


Pssm-ID: 443139  Cd Length: 335  Bit Score: 310.88  E-value: 1.95e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465   4 IRIIDSHTGGEPTRLVIGGFPDLGQGDMAERRRLLGERHDAWRAACILEPRGSDVLVGALLCAPVDPEACAGVIFFNNSG 83
Cdd:COG3938   7 ITTIDAHTEGEPTRVVTGGVPPLPGNTMLEKRRYFAENYDWLRRLLMFEPRGHADMSGALLVPPTRPDADFGVIFMETSG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465  84 YLGMCGHGTIGLVASLAHLGRIGP----GVHRIETPVGEVEATLH-EDG---SVSVRNVPAYRYRRQVSVEVPGIGRVSG 155
Cdd:COG3938  87 YLPMCGHGTIGVATVLLETGLVPMtepvTEVVLDTPAGLVRARAEvEDGkveSVTFENVPSFVYALDVEVEVPGLGTVTV 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465 156 DIAWGGNWFFLV--AGHGQRLAGDNLDALTAYTVAVQQALDDQ---------DIRGedggaIDHIELFAD--DPHADSRN 222
Cdd:COG3938 167 DIAYGGNFYAIVdaQQLGLDLEPENARELIRLGLEIRDAANEQlevvhpenpDING-----VSHVEFTGPptDPDADARN 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465 223 FVLCPGKAYDRSPCGTGTSAKLACLAADGKLLPGQPWRQASVIGSQFEGRYE---WLDGQPGgpIVPTIRGRAHVSAEAT 299
Cdd:COG3938 242 AVVFGPGAIDRSPCGTGTSARMALLHARGELKVGETFVHESIIGSRFTGRILeetTVGGYPA--IIPEITGRAWITGFNQ 319

                       330
                ....*....|..
gi 15596465 300 LLLADDDPFAWG 311
Cdd:COG3938 320 FVLDPDDPLPEG 331
PRK13971 PRK13971
4-hydroxyproline epimerase;
7-311 6.35e-80

4-hydroxyproline epimerase;


Pssm-ID: 184428  Cd Length: 333  Bit Score: 246.02  E-value: 6.35e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465    7 IDSHTGGEPTRLVIGGFPDLGQGDMAERRRLLGERHDAWRAACILEPRGSDVLVGALLCAPVDPEACAGVIFFNNSGYLG 86
Cdd:PRK13971   9 IDAHTCGNPVRLVAGGGPLLQGATMSEKRAHFLREYDWIRTGLMFEPRGHDMMSGSILYPPTRPDCDFAILFIETSGCLP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465   87 MCGHGTIGLVASLAHLGRIGP---GVHRIETPVGEVEATLHEDG----SVSVRNVPAYRYRRQVSVEVPGIGRVSGDIAW 159
Cdd:PRK13971  89 MCGHGTIGTVTAAIEEGLVTPktpGKLRLDTPAGLVDIEYEQDGekveSVRLTNVPSYLAAEDLEVEIPGLGPLKVDVAY 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465  160 GGNWFFLV------AGhgqrLAGDNLDALTAYTVAVQQAL---------DDQDIRGedggaIDHIeLFADDP---HADSR 221
Cdd:PRK13971 169 GGNFYAIVepqenfPG----LDHYSASDILRWSPVLRQALnekyefvhpEDPRIRG-----VSHV-LWTGKPispGADAR 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465  222 NFVLCPGKAYDRSPCGTGTSAKLACLAADGKLLPGQPWRQASVIGSQFEGRYE---WLDGQPGgpIVPTIRGRAHVSAEA 298
Cdd:PRK13971 239 NAVFYGDKAIDRSPCGTGTSARMAQLAAKGKLKVGDEFVHESIIGSLFEGRVEaaaTVGGRPA--ILPSIEGWARVTGHN 316

                        330
                 ....*....|...
gi 15596465  299 TLLLADDDPFAWG 311
Cdd:PRK13971 317 TIFVDDRDPYAHG 329
PRK13969 PRK13969
proline racemase; Provisional
 4-311 3.86e-74

proline racemase; Provisional


Pssm-ID: 184427 [Multi-domain]  Cd Length: 334  Bit Score: 231.28  E-value: 3.86e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465    4 IRIIDSHTGGEPTRLVIGGFPDLGQGDMAERRRLLGERHDAWRAACILEPRGSDVLVGALLCAPVDPEACAGVIFFNNSG 83
Cdd:PRK13969   7 IQTIDSHTMGEPTRIVVGGLPKIPGKTMAEKKEYLEENNDSLRTALMSEPRGHNDMFGSIYTEPADETADFGIIFMDGGG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465   84 YLGMCGHGTIGLVASLAHLGRI---GPGVH-RIETPVGEVEATLH-EDG---SVSVRNVPAYRYRRQVSVEVPGIGRVSG 155
Cdd:PRK13969  87 YLNMCGHGSIGAATCAVETGIVkveEPYTHiKLEAPAGMINARVKvEDGkakEVSIVNVPAFLYKKDVEIDVPDYGKVTL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465  156 DIAWGGNWFFLVAGH--GQRLAGDNLDALTAYTVAVQQALDDQ-DIRG---EDGGAIDHIELF--ADDPHADSRNFVLCP 227
Cdd:PRK13969 167 DISFGGSFFAIVDAEqlGIKISPANSQKLNDLGMKIRHAVNEQiEIKHpvlEHIKTVDLVEIYdeAKHPDADYKNVVIFG 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465  228 GKAYDRSPCGTGTSAKLACLAADGKLLPGQPWRQASVIGSQFEGRYewLDGQPGGP---IVPTIRGRAHVSAEATLLLAD 304
Cdd:PRK13969 247 QGQVDRSPCGTGTSAKMATLYAKGKLKVGEEFVYESIIGTKFKGKI--LEETKVGEydaIIPEITGSAYITGFNQFVIDE 324


                 ....*..
gi 15596465  305 DDPFAWG 311
Cdd:PRK13969 325 EDPVKYG 331
YHI9 COG0384
Predicted epimerase YddE/YHI9, PhzF superfamily [General function prediction only];
67-302 1.82e-08

Predicted epimerase YddE/YHI9, PhzF superfamily [General function prediction only];


Pssm-ID: 440153  Cd Length: 281  Bit Score: 54.45  E-value: 1.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465  67 PVDPEACAGVIFFNNSGYLGMCGHGTIGLVASLAHLGRIGPGVHRIETPVGEVEATLHEDGSVSVRNVPAYryrRQVSVE 146
Cdd:COG0384  52 PPEDPADYRLRWFTPTGEVPFCGHATLAAAHVLAEEGGLPGGRITFETKAGLLPVEVDGDGAWLEQDFPAL---PPEPVD 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465 147 VP------GIGRVSGD----IAWGGNWFFLVaghgqRLAgdNLDALTAYTV---AVQQALDDQDIRGedggaidhIELFA 213
Cdd:COG0384 129 PEelaaalGLSADDADlppeVVSTGLPDLLV-----PLA--SEEALRALRPdfaALAALSGRLGARG--------VYVFA 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596465 214 DDPHAD----SRNFvlCPGKAYDRSPcGTGT-SAKLACLAADGKLLPGQPW--RQASVIG--SQFEGRyewLDGQPGgpi 284
Cdd:COG0384 194 PGDDADadfvSRMF--APGVGIPEDP-ATGSaAAALAAYLAEKGGKPPTELtaEQGSEMGrpGRLHVE---LDGDGR--- 264

                       250
                ....*....|....*...
gi 15596465 285 vPTIRGRAHVSAEATLLL 302
Cdd:COG0384 265 -VRVGGRAVTVLEGELLL 281
DapF COG0253
Diaminopimelate epimerase [Amino acid transport and metabolism]; Diaminopimelate epimerase is ...
 78-131 2.06e-03

Diaminopimelate epimerase [Amino acid transport and metabolism]; Diaminopimelate epimerase is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440023 [Multi-domain]  Cd Length: 276  Bit Score: 38.95  E-value: 2.06e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15596465  78 FFNNSG-YLGMCGHGTIGLVASLAHLGRIGPGVHRIETPVGEVEATLHEDGSVSV 131
Cdd:COG0253  62 IFNADGsEAEMCGNGARCFARYLYDKGLTGKDEFTVETLAGVLRVEVEEDGLVTV 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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