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Conserved domains on  [gi|15596533|ref|NP_250027|]
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two-component sensor [Pseudomonas aeruginosa PAO1]

Protein Classification

sensor histidine kinase( domain architecture ID 11467953)

sensor histidine kinase may be part of a two-component regulatory system and function as a protein kinase that phosphorylates a target protein in response to a signal

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000156|GO:0000155|GO:0004673|GO:0007165|GO:0005524
PubMed:  10339418|11406410|10966457|8029829|18076326|11489844
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 276-620 3.53e-80

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


:

Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 257.80  E-value: 3.53e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 276 ADEQHPRGEAVTYLAQTRALNDTPWNLTLLSPLEDLRRDAVRNGMLAAIGFALLAFLLIAWNERRKVLATRLAAREALQR 355
Cdd:COG4191  10 LLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 356 ANGELEVKIAERTADLQASNARLTAEIHERQQAEDTLRKAQDELVQAGKLAVIGQMSTSIAHELNQPLAALRTLSGNTVR 435
Cdd:COG4191  90 LEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRR 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 436 FLQR-GKLETASTNLATINELVDRMGRITASLRAFARRSDDAGQA-SLAKAVDAALLILHGRLEQDPPTLHRHFDD--VR 511
Cdd:COG4191 170 RLEDePDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPvDLNELIDEALELLRPRLKARGIEVELDLPPdlPP 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 512 LGIDQTRLEQILVNLLANALDAMSGQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEHGLGLGLT 591
Cdd:COG4191 250 VLGDPGQLEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKGTGLGLS 329

                       330       340
                ....*....|....*....|....*....
gi 15596533 592 LSASLATAAGGSLSVQHPESGGTAFELSL 620
Cdd:COG4191 330 ISYGIVEKHGGRIEVESEPGGGTTFTITL 358
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 50-225 8.02e-16

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 77.38  E-value: 8.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533    50 IRALAENGERQLELHARTVESEISKYTYLPSLLELERSVSHLLTDPTpyrRNQVNAYLEGLNRRAGSRAVYLLDTNGRVL 129
Cdd:pfam02743   4 KEQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPA---EEELAKLESLLRSNPGISSIYLVDADGRVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533   130 ATSNwsDPDSYLGEDLSFRAYWQDAMKGKPGRFYGIGS-----TRGEPGYYLAHGLVHG-GRIIGVAVVKVKMDALEERW 203
Cdd:pfam02743  81 ASSD--ESPSYPGLDVSERPWYKEALKGGGGIIWVFSSpypssESGEPVLTIARPIYDDdGEVIGVLVADLDLDTLQELL 158

                         170       180
                  ....*....|....*....|....*.
gi 15596533   204 EKARL----EAFVSDENGIIILSSNP 225
Cdd:pfam02743 159 SQIKLgeggYVFIVDSDGRILAHPLG 184
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 276-620 3.53e-80

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 257.80  E-value: 3.53e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 276 ADEQHPRGEAVTYLAQTRALNDTPWNLTLLSPLEDLRRDAVRNGMLAAIGFALLAFLLIAWNERRKVLATRLAAREALQR 355
Cdd:COG4191  10 LLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 356 ANGELEVKIAERTADLQASNARLTAEIHERQQAEDTLRKAQDELVQAGKLAVIGQMSTSIAHELNQPLAALRTLSGNTVR 435
Cdd:COG4191  90 LEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRR 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 436 FLQR-GKLETASTNLATINELVDRMGRITASLRAFARRSDDAGQA-SLAKAVDAALLILHGRLEQDPPTLHRHFDD--VR 511
Cdd:COG4191 170 RLEDePDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPvDLNELIDEALELLRPRLKARGIEVELDLPPdlPP 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 512 LGIDQTRLEQILVNLLANALDAMSGQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEHGLGLGLT 591
Cdd:COG4191 250 VLGDPGQLEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKGTGLGLS 329

                       330       340
                ....*....|....*....|....*....
gi 15596533 592 LSASLATAAGGSLSVQHPESGGTAFELSL 620
Cdd:COG4191 330 ISYGIVEKHGGRIEVESEPGGGTTFTITL 358
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 519-620 1.96e-30

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 114.86  E-value: 1.96e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLANALDAMSGQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEHGLGLGLTLSASLAT 598
Cdd:cd16976   1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVE 80

                        90       100
                ....*....|....*....|..
gi 15596533 599 AAGGSLSVQHPESGGTAFELSL 620
Cdd:cd16976  81 EHGGRLSVANEEGAGARFTFDL 102
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 514-622 1.35e-27

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 107.35  E-value: 1.35e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533    514 IDQTRLEQILVNLLANALDAMsgQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGE---HGLGLGL 590
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYT--PEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrkiGGTGLGL 78

                           90       100       110
                   ....*....|....*....|....*....|..
gi 15596533    591 TLSASLATAAGGSLSVQHPESGGTAFELSLSL 622
Cdd:smart00387  79 SIVKKLVELHGGEISVESEPGGGTTFTITLPL 110
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
393-624 9.39e-27

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 115.07  E-value: 9.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  393 RKAQDELVQAGKLAVIGQMSTSIAHELNQPLAALRTLsgntVRFLQRGKLETASTN-LATINELVDRMGRITASLRAFAR 471
Cdd:PRK11360 375 KRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGY----VQIWRQQTSDPPSQEyLSVVLREVDRLNKVIDQLLEFSR 450

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  472 RSDDAGQA-SLAKAVDAALLILHGRLEQDPPTLHRHFD-DVRL-GIDQTRLEQILVNLLANALDAMSGQADRQL--WLEG 546
Cdd:PRK11360 451 PRESQWQPvSLNALVEEVLQLFQTAGVQARVDFETELDnELPPiWADPELLKQVLLNILINAVQAISARGKIRIrtWQYS 530

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596533  547 rreEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPgeHGLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSLSLVP 624
Cdd:PRK11360 531 ---DGQVAVSIEDNGCGIDPELLKKIFDPFFTTKA--KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINP 603
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 515-624 5.14e-25

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 99.75  E-value: 5.14e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533   515 DQTRLEQILVNLLANALDAMSGQADRQLWLEgrrEEERYVLRVRDNGPGIPPAARVHLFEPFFTT-KPGEHGLGLGLTLS 593
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTLS---EGGELTLTVEDNGIGIPPEDLPRIFEPFSTAdKRGGGGTGLGLSIV 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 15596533   594 ASLATAAGGSLSVQHPESGGTAFELSLSLVP 624
Cdd:pfam02518  79 RKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 50-225 8.02e-16

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 77.38  E-value: 8.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533    50 IRALAENGERQLELHARTVESEISKYTYLPSLLELERSVSHLLTDPTpyrRNQVNAYLEGLNRRAGSRAVYLLDTNGRVL 129
Cdd:pfam02743   4 KEQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPA---EEELAKLESLLRSNPGISSIYLVDADGRVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533   130 ATSNwsDPDSYLGEDLSFRAYWQDAMKGKPGRFYGIGS-----TRGEPGYYLAHGLVHG-GRIIGVAVVKVKMDALEERW 203
Cdd:pfam02743  81 ASSD--ESPSYPGLDVSERPWYKEALKGGGGIIWVFSSpypssESGEPVLTIARPIYDDdGEVIGVLVADLDLDTLQELL 158

                         170       180
                  ....*....|....*....|....*.
gi 15596533   204 EKARL----EAFVSDENGIIILSSNP 225
Cdd:pfam02743 159 SQIKLgeggYVFIVDSDGRILAHPLG 184
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 450-615 1.81e-11

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 66.85  E-value: 1.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533   450 ATINELVDRMGRITASLRAFARRSDDAGQASLAKAV-------DAALLILHGRLEQD------PPTLHRHFDDV------ 510
Cdd:TIGR02938 282 AAIHRLQGPMNLISAAISVLQRRGDDAGNPASAAMLqqalsagREHMEALRQVIPQSpqeivvPVNLNQILRDVitlstp 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533   511 RL---GI---------------DQTRLEQILVNLLANALDAMS--GQADRQLWLEGRREEERYVLRVRDNGPGIPPAARV 570
Cdd:TIGR02938 362 RLlaaGIvvdwqpaatlpailgRELQLRSLFKALVDNAIEAMNikGWKRRELSITTALNGDLIVVSILDSGPGIPQDLRY 441

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 15596533   571 HLFEPFFTTKPG-EHGLGLGLTLSASLATAAGGSLSVQHPESGGTA 615
Cdd:TIGR02938 442 KVFEPFFTTKGGsRKHIGMGLSVAQEIVADHGGIIDLDDDYSEGCR 487
PDC1_DGC_like cd12914
first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this ...
 86-196 1.43e-07

first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the first PDC domain of Diguanylate-cyclases (DGCs), Histidine kinases (HKs), and other similar domains. Many members of this subfamily contain a C-terminal DGC (also called GGDEF) domain. DGCs regulate the turnover of cyclic diguanosine monophosphate. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.


Pssm-ID: 350339  Cd Length: 123  Bit Score: 50.46  E-value: 1.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  86 RSVSHLLTDPTPYRRN--QVNAYLEGLNRRAGS-RAVYLLDTNGRVLATSNwsdPDSYLGEDLSFRAYWQDAMKGKPGRF 162
Cdd:cd12914   9 RSLADDLEARGAASADpaALQALLRRLLARLPEvRSIFVVDADGRVVASSG---PGPAPGLDVSDRDYFQAARAGGGGLF 85

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15596533 163 YG---IGSTRGEPGYYLAHGLVH-GGRIIGVAVVKVKM 196
Cdd:cd12914  86 ISepvISRVTGKPVIPLSRPIRDaDGRFAGVVVASIDL 123
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 276-620 3.53e-80

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 257.80  E-value: 3.53e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 276 ADEQHPRGEAVTYLAQTRALNDTPWNLTLLSPLEDLRRDAVRNGMLAAIGFALLAFLLIAWNERRKVLATRLAAREALQR 355
Cdd:COG4191  10 LLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 356 ANGELEVKIAERTADLQASNARLTAEIHERQQAEDTLRKAQDELVQAGKLAVIGQMSTSIAHELNQPLAALRTLSGNTVR 435
Cdd:COG4191  90 LEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRR 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 436 FLQR-GKLETASTNLATINELVDRMGRITASLRAFARRSDDAGQA-SLAKAVDAALLILHGRLEQDPPTLHRHFDD--VR 511
Cdd:COG4191 170 RLEDePDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPvDLNELIDEALELLRPRLKARGIEVELDLPPdlPP 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 512 LGIDQTRLEQILVNLLANALDAMSGQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEHGLGLGLT 591
Cdd:COG4191 250 VLGDPGQLEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKGTGLGLS 329

                       330       340
                ....*....|....*....|....*....
gi 15596533 592 LSASLATAAGGSLSVQHPESGGTAFELSL 620
Cdd:COG4191 330 ISYGIVEKHGGRIEVESEPGGGTTFTITL 358
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 321-606 2.43e-54

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 196.06  E-value: 2.43e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 321 LAAIGFALLAFLLIAWNERRKVLATRLAA-REALQR-ANGELEVKI-----------AER----TADLQASNARLTAEIH 383
Cdd:COG4192 329 LAIALLSLLLAVLINYFYVRRRLVKRLNAlSDAMAAiAAGDLDVPIpvdgndeigriARLlrvfRDQAIEKTQELETEIE 408

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 384 ERQQAEDTLRKAQDELVQAGKLAVIGQMSTSIAHELNQPLAALRTLSGNTVRFLQRGKLETASTNLATINELVDRMGRIT 463
Cdd:COG4192 409 ERKRIEKNLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALEQENYAQLPTSLDKIEGLIERMDKII 488

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 464 ASLRAFARRSDDAGQA-SLAKAVDAALLILHGRLEQDPPTLHRHfDDVRLGIDQTRLEQILVNLLANALDAMSGQADRQL 542
Cdd:COG4192 489 KSLRQFSRKSDTPLQPvDLRQVIEQAWELVESRAKPQQITLHIP-DDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISV 567

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596533 543 WLEgrREEERYVLRVRDNGPGIPPAARvhLFEPFFTTKpgEHGLGLGLTLSASLATAAGGSLSV 606
Cdd:COG4192 568 DLL--SNAENLRVAISDNGNGWPLVDK--LFTPFTTTK--EVGLGLGLSICRSIMQQFGGDLYL 625
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 308-627 1.85e-45

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 166.68  E-value: 1.85e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 308 LEDLRR--DAVRNGMLAAIgfallafllIAWNERRKVLATRLAAREALQRANGELEVKIAERTADLQASNARLTAEIHER 385
Cdd:COG5000  85 LEERRRylETILENLPAGV---------IVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREALERG 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 386 QQAEDTLRKAQD-----------------------ELVQAGKLAVIGQMSTSIAHELNQPLAALRTLSGNTVRFLQRGKL 442
Cdd:COG5000 156 WQEEIELTRDGRrtllvrasplrddgyvivfdditELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLE 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 443 ETAST---NLATINELVDRMGRITASLRAFARRSD-DAGQASLAKAVDAALLILHGRLEQDPPTLHRHFDDVRLGI--DQ 516
Cdd:COG5000 236 EDREDlerALDTIIRQVDRLKRIVDEFLDFARLPEpQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVlaDR 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 517 TRLEQILVNLLANALDAMSGQAdrQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPgeHGLGLGLTLSASL 596
Cdd:COG5000 316 DQLEQVLINLLKNAIEAIEEGG--EIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKP--KGTGLGLAIVKKI 391

                       330       340       350
                ....*....|....*....|....*....|.
gi 15596533 597 ATAAGGSLSVQHPESGGTAFELSLSLVPDSP 627
Cdd:COG5000 392 VEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
340-629 1.06e-43

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 160.40  E-value: 1.06e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 340 RKVLATRLAARE---ALQRANGElevkiaERTADLQAS-------NARLTAEIHERQQAedtlRKAQDELVQAGKLAVIG 409
Cdd:COG3852  67 ERALAEGQPVTErevTLRRKDGE------ERPVDVSVSplrdaegEGGVLLVLRDITER----KRLERELRRAEKLAAVG 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 410 QMSTSIAHELNQPLAALRtlsGNTVRFLQRGKLETASTNLATINELVDRMGRITASLRAFARRSDDAGQA-SLAKAVDAA 488
Cdd:COG3852 137 ELAAGLAHEIRNPLTGIR---GAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPvNLHEVLERV 213

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 489 LLILHGRLEQDPpTLHRHFD----DVRlgIDQTRLEQILVNLLANALDAMSGQ--------ADRQLWLEGRREEERYVLR 556
Cdd:COG3852 214 LELLRAEAPKNI-RIVRDYDpslpEVL--GDPDQLIQVLLNLVRNAAEAMPEGgtitirtrVERQVTLGGLRPRLYVRIE 290

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15596533 557 VRDNGPGIPPAARVHLFEPFFTTKPGehGLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSLSLVPDSPTA 629
Cdd:COG3852 291 VIDNGPGIPEEILDRIFEPFFTTKEK--GTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEEP 361
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
290-620 3.66e-42

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 155.07  E-value: 3.66e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 290 AQTRALNDTPWNLTLLSPLEDLRRDAVRNGMLAAIGFALLAFLLIAWNERRKVLATRLAAREALQRANGELEVKIAERTA 369
Cdd:COG0642   1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 370 DLQASNARLTAEIHERQQAEDTLRKAQDELvqagklaviGQMSTSIAHELNQPLAALRTLsgntVRFLQRGKLETASTNL 449
Cdd:COG0642  81 LLLLLLLLLLLLLLLLLALLLLLEEANEAK---------SRFLANVSHELRTPLTAIRGY----LELLLEELDEEQREYL 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 450 ATINELVDRMGRITASLRAFARRsdDAGQA-------SLAKAVDAALLILHGRLEQDPPTLHRHFDD--VRLGIDQTRLE 520
Cdd:COG0642 148 ETILRSADRLLRLINDLLDLSRL--EAGKLelepepvDLAELLEEVVELFRPLAEEKGIELELDLPDdlPTVRGDPDRLR 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 521 QILVNLLANALDAMsgQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPG--EHGLGLGLTLSASLAT 598
Cdd:COG0642 226 QVLLNLLSNAIKYT--PEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSrrGGGTGLGLAIVKRIVE 303

                       330       340
                ....*....|....*....|..
gi 15596533 599 AAGGSLSVQHPESGGTAFELSL 620
Cdd:COG0642 304 LHGGTIEVESEPGKGTTFTVTL 325
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
392-620 1.85e-36

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 136.58  E-value: 1.85e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 392 LRKAQDELVQAGKLavIGQMSTSIAHELNQPLAALRTLSGntvrFLQRGKLETAST---NLATINELVDRMGRITASLRA 468
Cdd:COG2205   2 LEEALEELEELERL--KSEFLANVSHELRTPLTSILGAAE----LLLDEEDLSPEErreLLEIIRESAERLLRLIEDLLD 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 469 FARRsdDAGQASLAKA-------VDAALLILHGRLEQDPPTLHRHF--DDVRLGIDQTRLEQILVNLLANALDAmsGQAD 539
Cdd:COG2205  76 LSRL--ESGKLSLELEpvdlaelLEEAVEELRPLAEEKGIRLELDLppELPLVYADPELLEQVLANLLDNAIKY--SPPG 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 540 RQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTK--PGEHGLGLGLTLSASLATAAGGSLSVQHPESGGTAFE 617
Cdd:COG2205 152 GTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDnsRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFT 231


                ...
gi 15596533 618 LSL 620
Cdd:COG2205 232 VTL 234
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 519-620 1.96e-30

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 114.86  E-value: 1.96e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLANALDAMSGQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEHGLGLGLTLSASLAT 598
Cdd:cd16976   1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVE 80

                        90       100
                ....*....|....*....|..
gi 15596533 599 AAGGSLSVQHPESGGTAFELSL 620
Cdd:cd16976  81 EHGGRLSVANEEGAGARFTFDL 102
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
284-625 2.26e-30

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 123.51  E-value: 2.26e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 284 EAVTYLAQTRALNDTPWNLTLLSPLEDLRRDAVRNGMLAAIGFALLAFLLIAWNERRKVLATRLAAREALQRANGELEVK 363
Cdd:COG5002  57 LLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSL 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 364 IAERTADLQASNARLTAEIHERQQAEdtlrKAQDELVQagklavigqmstSIAHELNQPLAALRTLsgntVRFLQRGKL- 442
Cdd:COG5002 137 RLSALLLGLLLLAAVERDITELERLE----QMRREFVA------------NVSHELRTPLTSIRGY----LELLLDGAAd 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 443 --ETASTNLATINELVDRMGRITASLRAFARrsDDAGQA-------SLAKAVDAALLILHGRLEQDPPTLHRHF--DDVR 511
Cdd:COG5002 197 dpEERREYLEIILEEAERLSRLVNDLLDLSR--LESGELklekepvDLAELLEEVVEELRPLAEEKGIELELDLpeDPLL 274

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 512 LGIDQTRLEQILVNLLANALDAmsGQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPG----EHGLG 587
Cdd:COG5002 275 VLGDPDRLEQVLTNLLDNAIKY--TPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSrsreTGGTG 352

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 15596533 588 LGLTLSASLATAAGGSLSVQHPESGGTAFELSLSLVPD 625
Cdd:COG5002 353 LGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
KinC COG5807
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...
 394-623 3.17e-30

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444509 [Multi-domain]  Cd Length: 358  Bit Score: 122.20  E-value: 3.17e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 394 KAQDELVQAGKLAVIGQMSTSIAHELNQPLAALRTlsgntvrFLQRgkLETASTNLAT------INELVDRMGRITASLR 467
Cdd:COG5807 133 EAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKG-------FLQL--LQESREDSEReeyfniIISEIDRINTIITELL 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 468 AFAR-RSDDAGQASLAKAVD--AALL----ILHG-RLEQDPPTlhrhfDDVRLGIDQTRLEQILVNLLANALDAMSGQAd 539
Cdd:COG5807 204 VLSKpKKFNFKKLNLNDVLEdvIALLsteaILKNiSIKYDLAD-----DEPVINGDKNQLKQVFINLIKNAIEAMETGG- 277

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 540 rQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKpgEHGLGLGLTLSASLATAAGGSLSVQHPESGGTAFELS 619
Cdd:COG5807 278 -NITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTK--EEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIY 354


                ....
gi 15596533 620 LSLV 623
Cdd:COG5807 355 LPLY 358
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 519-620 1.50e-28

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 109.61  E-value: 1.50e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLANALDAMSgqADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEH--GLGLGLTLSASL 596
Cdd:cd00075   1 LEQVLSNLLDNALKYSP--PGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREggGTGLGLAIVRRI 78

                        90       100
                ....*....|....*....|....
gi 15596533 597 ATAAGGSLSVQHPESGGTAFELSL 620
Cdd:cd00075  79 VEAHGGRITVESEPGGGTTFTVTL 102
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 514-622 1.35e-27

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 107.35  E-value: 1.35e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533    514 IDQTRLEQILVNLLANALDAMsgQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGE---HGLGLGL 590
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYT--PEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrkiGGTGLGL 78

                           90       100       110
                   ....*....|....*....|....*....|..
gi 15596533    591 TLSASLATAAGGSLSVQHPESGGTAFELSLSL 622
Cdd:smart00387  79 SIVKKLVELHGGEISVESEPGGGTTFTITLPL 110
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 382-623 5.03e-27

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 115.21  E-value: 5.03e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 382 IHERQQAEDTLRKAQdelvqagKLAVIGQMSTSIAHELNQPLAALRtlsGntvrFLQ--RGKLETASTNLATINELVDRM 459
Cdd:COG5805 268 ITEKKEAEELMARSE-------KLSIAGQLAAGIAHEIRNPLTSIK---G----FLQllQPGIEDKEEYFDIMLSELDRI 333

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 460 GRITASLRAFARRSDDAGQA----SLAKAVdAALL----ILHGRleqdppTLHRHFDDVRLGI--DQTRLEQILVNLLAN 529
Cdd:COG5805 334 ESIISEFLALAKPQAVNKEKeninELIQDV-VTLLeteaILHNI------QIRLELLDEDPFIycDENQIKQVFINLIKN 406

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 530 ALDAM--SGQADRQLwlegrREEERYV-LRVRDNGPGIPPAARVHLFEPFFTTKpgEHGLGLGLTLSASLATAAGGSLSV 606
Cdd:COG5805 407 AIEAMpnGGTITIHT-----EEEDNSViIRVIDEGIGIPEERLKKLGEPFFTTK--EKGTGLGLMVSYKIIENHNGTIDI 479

                       250
                ....*....|....*..
gi 15596533 607 QHPESGGTAFELSLSLV 623
Cdd:COG5805 480 DSKVGKGTTFTITLPLS 496
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
393-624 9.39e-27

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 115.07  E-value: 9.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  393 RKAQDELVQAGKLAVIGQMSTSIAHELNQPLAALRTLsgntVRFLQRGKLETASTN-LATINELVDRMGRITASLRAFAR 471
Cdd:PRK11360 375 KRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGY----VQIWRQQTSDPPSQEyLSVVLREVDRLNKVIDQLLEFSR 450

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  472 RSDDAGQA-SLAKAVDAALLILHGRLEQDPPTLHRHFD-DVRL-GIDQTRLEQILVNLLANALDAMSGQADRQL--WLEG 546
Cdd:PRK11360 451 PRESQWQPvSLNALVEEVLQLFQTAGVQARVDFETELDnELPPiWADPELLKQVLLNILINAVQAISARGKIRIrtWQYS 530

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596533  547 rreEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPgeHGLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSLSLVP 624
Cdd:PRK11360 531 ---DGQVAVSIEDNGCGIDPELLKKIFDPFFTTKA--KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINP 603
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 100-624 1.77e-26

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 113.73  E-value: 1.77e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 100 RNQVNAYLEGLNRRAGSRAVYLLDTNGRVLATSNWSDPDSYLGEDLSFRAYWQDAMKGKPGRFYGIGSTRGEPGYYLAHG 179
Cdd:COG4251   1 LLLLALLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 180 LVHGGRIIGVAVVKVKMDALEERWEKARLEAFVSDENGIIILSSNPALRLKAVRSLSADDKERLARSMQYYWWALNEWQP 259
Cdd:COG4251  81 LLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 260 LQREPLAAGVEKLSFPADEQHPRGEAVTYLAQTRALNDTPWNLTLLSPLEDLRRDAVRNGMLAAIGFALLAFLLIAW--- 336
Cdd:COG4251 161 LLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLlll 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 337 NERRKVLATRLAAREALQRANGELEVKIAERTADLQASNARLTaeiherqqaedtlrkaqdelvqagklavigQMSTSIA 416
Cdd:COG4251 241 LILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELE------------------------------QFAYVAS 290

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 417 HELNQPLAALRTLSgntvRFLQR---GKL-ETASTNLATINELVDRMGRITASLRAFAR---RSDDAGQASLAKAVDAAL 489
Cdd:COG4251 291 HDLREPLRKISGFS----QLLEEdygDKLdEEGREYLERIRDAAERMQALIDDLLAYSRvgrQELEFEPVDLNELLEEVL 366

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 490 LILHGRLEQDPPTLHRHfDDVRLGIDQTRLEQILVNLLANALDAMSGQADRQLWLEGRREEERYVLRVRDNGPGIPPAAR 569
Cdd:COG4251 367 EDLEPRIEERGAEIEVG-PLPTVRGDPTLLRQVFQNLISNAIKYSRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYA 445

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15596533 570 VHLFEPFFTTKPGEH--GLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSLSLVP 624
Cdd:COG4251 446 EKIFEIFQRLHSRDEyeGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAP 502
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 519-620 2.10e-25

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 100.55  E-value: 2.10e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLANALDAMSGQAD--RQLWLEGRREEERYV-LRVRDNGPGIPPAARVHLFEPFFTTKPgeHGLGLGLTLSAS 595
Cdd:cd16920   1 IQQVLINLVRNGIEAMSEGGCerRELTIRTSPADDRAVtISVKDTGPGIAEEVAGQLFDPFYTTKS--EGLGMGLSICRS 78

                        90       100
                ....*....|....*....|....*
gi 15596533 596 LATAAGGSLSVQHPESGGTAFELSL 620
Cdd:cd16920  79 IIEAHGGRLSVESPAGGGATFQFTL 103
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 515-624 5.14e-25

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 99.75  E-value: 5.14e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533   515 DQTRLEQILVNLLANALDAMSGQADRQLWLEgrrEEERYVLRVRDNGPGIPPAARVHLFEPFFTT-KPGEHGLGLGLTLS 593
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTLS---EGGELTLTVEDNGIGIPPEDLPRIFEPFSTAdKRGGGGTGLGLSIV 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 15596533   594 ASLATAAGGSLSVQHPESGGTAFELSLSLVP 624
Cdd:pfam02518  79 RKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
PRK15347 PRK15347
two component system sensor kinase;
359-622 6.55e-25

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 110.50  E-value: 6.55e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  359 ELEVKIAERTADLQASnarltaeiheRQQAEDTLRKAQDELvqagklavigqmsTSIAHELNQPL----AALRTLSGNTV 434
Cdd:PRK15347 372 TLENKVAERTQALAEA----------KQRAEQANKRKSEHL-------------TTISHEIRTPLngvlGALELLQNTPL 428

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  435 RFLQRGKLETA--STN--LATINELVD--RM--GRITASLRafarrsddagQASLAKAVDAALLILHGRLEQDPPTLhRH 506
Cdd:PRK15347 429 TAEQMDLADTArqCTLslLAIINNLLDfsRIesGQMTLSLE----------ETALLPLLDQAMLTIQGPAQSKSLTL-RT 497

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  507 F--DDV--RLGIDQTRLEQILVNLLANALDAMSgqaDRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPG 582
Cdd:PRK15347 498 FvgAHVplYLHLDSLRLRQILVNLLGNAVKFTE---TGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTH 574

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 15596533  583 EHGLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSLSL 622
Cdd:PRK15347 575 SQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPL 614
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 393-623 7.87e-25

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 107.91  E-value: 7.87e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 393 RKAQDElvQAGKLAVIGQMSTSIAHELNQPLAALrtlSGnTVRFLQRGKLETASTN-LATINELVDRMGRITASLRAFAR 471
Cdd:COG5808 228 RVIQEI--NTQKLELIGTFAASTAHEIRNPLTSI---KG-FIQLLQEKYPELEDQKyFDIIQEEIQRINQIVSEFLVLGK 301

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 472 RSD-DAGQASLAKAVDAALLILHGRLEQDPPTLHRHFDDVRLGI--DQTRLEQILVNLLANALDAMsgQADRQLWLEGRR 548
Cdd:COG5808 302 PTAkKLELDDLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIkcDKDRIKQVLLNLIKNAIEAM--KEGGKLTISIEN 379

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15596533 549 EEERYVLRVRDNGPGIPPAARVHLFEPFFTTKpgEHGLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSLSLV 623
Cdd:COG5808 380 DDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTK--EGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPLK 452
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 382-627 1.02e-24

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 108.14  E-value: 1.02e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 382 IHERQQAEDTLRKAQdelvqagKLAVIGQMSTSIAHELNQPLAALRTLsgntVRFLQRGKLETASTNLATINELVDRMGR 461
Cdd:COG5809 251 ITERKKLEELLRKSE-------KLSVVGELAAGIAHEIRNPLTSLKGF----IQLLKDTIDEEQKTYLDIMLSELDRIES 319

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 462 ITASLRAFARRSDDAGQ----ASLAKAVdAALL----ILHG-----RLEQDPPTLhrhfddvrLGiDQTRLEQILVNLLA 528
Cdd:COG5809 320 IISEFLVLAKPQAIKYEpkdlNTLIEEV-IPLLqpqaLLKNvqielELEDDIPDI--------LG-DENQLKQVFINLLK 389

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 529 NALDAMSGQAdrQLWLEGRREEERYV-LRVRDNGPGIPPAaRVH-LFEPFFTTKpgEHGLGLGLTLSASLATAAGGSLSV 606
Cdd:COG5809 390 NAIEAMPEGG--NITIETKAEDDDKVvISVTDEGCGIPEE-RLKkLGEPFYTTK--EKGTGLGLMVSYKIIEEHGGKITV 464

                       250       260
                ....*....|....*....|.
gi 15596533 607 QHPESGGTAFELSLSLVPDSP 627
Cdd:COG5809 465 ESEVGKGTTFSITLPIKLSEQ 485
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 519-622 3.17e-23

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 94.41  E-value: 3.17e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLANALDAMSGQAdrQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEHGLGLGLTLSASLAT 598
Cdd:cd16943   4 LNQVLLNLLVNAAQAMEGRG--RITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQ 81

                        90       100
                ....*....|....*....|....
gi 15596533 599 AAGGSLSVQHPESGGTAFELSLSL 622
Cdd:cd16943  82 KHGGTIRVASVPGGGTRFTIILPI 105
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 350-620 7.06e-23

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 101.08  E-value: 7.06e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 350 REALQRANGELEVKIAERTADLQASNARLTAEIherQQAEDTLRKAQDELVQAGKLAVIGQMSTSI---AHEL-NQplaa 425
Cdd:COG3290 131 AEVLETGERDEEILLNGRVLVVNRVPIRDDGRV---VGAVATFRDRTELERLEEELEGVKELAEALraqRHDFrNH---- 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 426 LRTLSGntvrFLQRGKLETAstnLATINELVDRMGRITASLRafaRRSDDAgqaslakAVDAALLILHGR-LEQDPP-TL 503
Cdd:COG3290 204 LHTISG----LLQLGEYDEA---LEYIDEISEELQELIDSLL---SRIGNP-------VLAALLLGKAARaRERGIDlTI 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 504 HRHFDDVRLGIDQTRLEQILVNLLANALDAMSGQAD--RQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKP 581
Cdd:COG3290 267 DIDSDLPDLPLSDTDLVTILGNLLDNAIEAVEKLPEeeRRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKL 346

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 15596533 582 GeHGLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSL 620
Cdd:COG3290 347 G-EGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
PRK13557 PRK13557
histidine kinase; Provisional
 381-619 8.52e-22

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 99.36  E-value: 8.52e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  381 EIHERQQAEDTLRKAQdelvqagKLAVIGQMSTSIAHELNQPLAALRtlsgntvrflqrGKLETASTNLATINELVDRMG 460
Cdd:PRK13557 143 DVSRRRDAEDALRQAQ-------KMEALGQLTGGIAHDFNNLLQVMS------------GYLDVIQAALSHPDADRGRMA 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  461 RITASLRAFARRSDDAGQASLAKA----VDAALLILHGRLEQDPPTLHRHF-DDVRLG-----------IDQTRLEQILV 524
Cdd:PRK13557 204 RSVENIRAAAERAATLTQQLLAFArkqrLEGRVLNLNGLVSGMGELAERTLgDAVTIEtdlapdlwncrIDPTQAEVALL 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  525 NLLANALDAMSGQ------------ADRQLWLEGRREEERYV-LRVRDNGPGIPPAARVHLFEPFFTTKPGEHGLGLGLT 591
Cdd:PRK13557 284 NVLINARDAMPEGgrvtirtrnveiEDEDLAMYHGLPPGRYVsIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLS 363

                        250       260
                 ....*....|....*....|....*...
gi 15596533  592 LSASLATAAGGSLSVQHPESGGTAFELS 619
Cdd:PRK13557 364 MVYGFAKQSGGAVRIYSEVGEGTTVRLY 391
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
212-622 3.92e-21

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 96.78  E-value: 3.92e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  212 VSDENGIIILSSNPALRLKAVrsLSADDKERLARSMQYYWWALNEWQPlqrEPLAAgVEKLSFPADEQHPRGeavtYLAQ 291
Cdd:PRK10364  92 VTDEQGTIVAHSNPGMVGKQL--YSPQEMQQLHPGDEEAWRRIDSADG---EPVLE-IYRQFQPMFAAGMHG----MRHM 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  292 TRALNDTPWNLTLL----SPLEDLRRDAVRNgmLAAIGFALLAFLLiawnerrkvlATRLA---AREALQrangelevki 364
Cdd:PRK10364 162 QQYAAANTPQAIFIafdaSNLVSAQAREQRN--TLIILFALATVLL----------ASLLAffwYRRYLR---------- 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  365 aertadlqasnarltaeihERQQAEDTLRKAQdelvqagKLAVIGQMSTSIAHELNQPLAALRTLSgntVRFLQRGKLET 444
Cdd:PRK10364 220 -------------------SRQLLQDEMKRKE-------KLVALGHLAAGVAHEIRNPLSSIKGLA---KYFAERAPAGG 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  445 ASTNLAT--INElVDRMGRITASLRAFARRSDDAGQAslakaVDAALLILHGR--LEQDP------------PTLHRhfd 508
Cdd:PRK10364 271 EAHQLAQvmAKE-ADRLNRVVSELLELVKPTHLALQA-----VDLNDLINHSLqlVSQDAnsreiqlrftanDTLPE--- 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  509 dvrLGIDQTRLEQILVNLLANALDAMSGQAdrQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKpgEHGLGL 588
Cdd:PRK10364 342 ---IQADPDRLTQVLLNLYLNAIQAIGQHG--VISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTK--AEGTGL 414

                        410       420       430
                 ....*....|....*....|....*....|....
gi 15596533  589 GLTLSASLATAAGGSLSVQHPESGGTAFELSLSL 622
Cdd:PRK10364 415 GLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
384-632 3.78e-19

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 92.05  E-value: 3.78e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  384 ERQQAEDTLRKAQDELVQAGKLAVIGQMSTSIAHELNQPLAALR---TLSGNTVRFLQRgkletASTNLATINELVDRMG 460
Cdd:PRK13837 426 ERRRLETERDALERRLEHARRLEAVGTLASGIAHNFNNILGAILgyaEMALNKLARHSR-----AARYIDEIISAGARAR 500

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  461 RITASLRAFARRSDDAGQ-ASLAKAVDAALLILHGRLeqdPPT----LHRHFDDVRLGIDQTRLEQILVNLLANALDAMS 535
Cdd:PRK13837 501 LIIDQILAFGRKGERNTKpFDLSELVTEIAPLLRVSL---PPGveldFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMD 577

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  536 G------QADRQlwlEGRREEE---------RYV-LRVRDNGPGIPPAARVHLFEPFFTTKPGehGLGLGLTLSASLATA 599
Cdd:PRK13837 578 GagrvdiSLSRA---KLRAPKVlshgvlppgRYVlLRVSDTGAGIDEAVLPHIFEPFFTTRAG--GTGLGLATVHGIVSA 652

                        250       260       270
                 ....*....|....*....|....*....|...
gi 15596533  600 AGGSLSVQHPESGGTAFELSLSLVPDSPTASPA 632
Cdd:PRK13837 653 HAGYIDVQSTVGRGTRFDVYLPPSSKVPVAPQA 685
PRK10604 PRK10604
sensor protein RstB; Provisional
 410-632 1.21e-18

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 88.89  E-value: 1.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  410 QMSTSIAHELNQPLAALRtlsgntVRfLQRGKLETAStNLATINELVDRMGRITASLRAFARRsdDAGQASLAKAVDAAL 489
Cdd:PRK10604 214 QLIDGIAHELRTPLVRLR------YR-LEMSDNLSAA-ESQALNRDIGQLEALIEELLTYARL--DRPQNELHLSEPDLP 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  490 LILHGRLEqDPPTLH--RHFDDVRL------GIDQTRLEQILVNLLANALDAMSGQADRQLWLEGrreeERYVLRVRDNG 561
Cdd:PRK10604 284 AWLSTHLA-DIQAVTpeKTVRLDTPhqgdygALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDG----NQACLIVEDDG 358

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15596533  562 PGIPPAARVHLFEPFFTTKPGEH----GLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSLSLVPDSPTASPA 632
Cdd:PRK10604 359 PGIPPEERERVFEPFVRLDPSRDratgGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVWHNLPQFTSA 433
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 352-630 3.77e-18

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 88.81  E-value: 3.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  352 ALQRANGELEVKIAERTADLQASnarltaeIHERQQAedtlrKAQDELVQAGKLAVIGQMSTSIAHELNQPLAALRTLSG 431
Cdd:PRK11466 404 ALNRHREQLAAQVKARTAELQEL-------VIEHRQA-----RAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLAD 471

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  432 NTVRFLQRGKL----ETASTNLATINELVDRMG------RITASLRAFARRsddagqaslaKAVDAALLILHGRLEQDPP 501
Cdd:PRK11466 472 NPALNAQRDDLraitDSGESLLTILNDILDYSAieaggkNVSVSDEPFEPR----------PLLESTLQLMSGRVKGRPI 541

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  502 TLHRHFDDV---RLGIDQTRLEQILVNLLANALDAmsgqADR-QLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFF 577
Cdd:PRK11466 542 RLATDIADDlptALMGDPRRIRQVITNLLSNALRF----TDEgSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFV 617

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15596533  578 TTKPGEHGLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSLSL---VPDSPTAS 630
Cdd:PRK11466 618 QVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLrvaTAPVPKTV 673
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 522-620 1.97e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 78.10  E-value: 1.97e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 522 ILVNLLANALDAMSGQAD--RQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTK-PGEHGLGLGLTlsASLAT 598
Cdd:cd16915   4 IVGNLIDNALDALAATGApnKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKgQGERGIGLALV--RQSVE 81

                        90       100
                ....*....|....*....|..
gi 15596533 599 AAGGSLSVQHPESGGTAFELSL 620
Cdd:cd16915  82 RLGGSITVESEPGGGTTFSIRI 103
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 519-622 2.88e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 74.84  E-value: 2.88e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLANAL---DamSGQADRQLWLEGRrEEERYVLR--VRDNGPGIPPAARVHLFEPF------FTTKPGehGLG 587
Cdd:cd16922   1 LRQILLNLLGNAIkftE--EGEVTLRVSLEEE-EEDGVQLRfsVEDTGIGIPEEQQARLFEPFsqadssTTRKYG--GTG 75

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15596533 588 LGLTLSASLATAAGGSLSVQhPESG-GTAFELSLSL 622
Cdd:cd16922  76 LGLAISKKLVELMGGDISVE-SEPGqGSTFTFTLPL 110
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 50-225 8.02e-16

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 77.38  E-value: 8.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533    50 IRALAENGERQLELHARTVESEISKYTYLPSLLELERSVSHLLTDPTpyrRNQVNAYLEGLNRRAGSRAVYLLDTNGRVL 129
Cdd:pfam02743   4 KEQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPA---EEELAKLESLLRSNPGISSIYLVDADGRVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533   130 ATSNwsDPDSYLGEDLSFRAYWQDAMKGKPGRFYGIGS-----TRGEPGYYLAHGLVHG-GRIIGVAVVKVKMDALEERW 203
Cdd:pfam02743  81 ASSD--ESPSYPGLDVSERPWYKEALKGGGGIIWVFSSpypssESGEPVLTIARPIYDDdGEVIGVLVADLDLDTLQELL 158

                         170       180
                  ....*....|....*....|....*.
gi 15596533   204 EKARL----EAFVSDENGIIILSSNP 225
Cdd:pfam02743 159 SQIKLgeggYVFIVDSDGRILAHPLG 184
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 305-620 1.00e-15

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 80.27  E-value: 1.00e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  305 LSPLEDLRRDAVRNGMLAAIGFALLAFLLIAWnerRKVLATRLAAREALQRANGelevkiaeRTADLQASNARltaEIHE 384
Cdd:PRK11100 173 MAPFIKRSERRILWAGALLLGIALLIGAGVVW---WLNRSIRRLTRYADAVTEG--------KPVPLPKLGSS---ELRE 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  385 RQQAEDTLRkaqDELvqAGKlAVIGQMSTSIAHELNQPLAALR--------TLSGNTV-RFLQRGKLETAStnlatINEL 455
Cdd:PRK11100 239 LAQALESMR---VKL--EGK-AYVEQYVQTLTHELKSPLAAIRgaaellqeDPPPEDRaRFTGNILTQSAR-----LQQL 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  456 VDRMGRITaslRAFARRS-DDAGQASLAKAVDAALLILHGRLEQDPPTLHRHFDDVRLGIDQTRLEQILVNLLANALDaM 534
Cdd:PRK11100 308 IDRLLELA---RLEQRQElEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAID-F 383

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  535 SGQADRqLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTT-KP--GEHGLGLGLTLSASLATAAGGSLSVQHPES 611
Cdd:PRK11100 384 SPEGGT-ITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSLpRPanGRKSTGLGLAFVREVARLHGGEVTLRNRPE 462


                 ....*....
gi 15596533  612 GGTAFELSL 620
Cdd:PRK11100 463 GGVLATLTL 471
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 519-622 2.35e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 72.08  E-value: 2.35e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLANALDamsgQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEH----GLGLGLTLSA 594
Cdd:cd16939   1 MARALDNLLRNALR----YAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDratgGFGLGLAIVH 76

                        90       100
                ....*....|....*....|....*...
gi 15596533 595 SLATAAGGSLSVQHPESGGTAFELSLSL 622
Cdd:cd16939  77 RVALWHGGHVECDDSELGGACFRLTWPR 104
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 519-620 4.79e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 71.28  E-value: 4.79e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLANALDAMSGQ---------ADRQLWLegRREEERYVLRVR--DNGPGIPPAARVHLFEPFFTTKPGehGLG 587
Cdd:cd16918   1 LIQVFLNLVRNAAQALAGSggeiilrtrTQRQVTL--GHPRHRLALRVSviDNGPGIPPDLQDTIFYPMVSGREN--GTG 76

                        90       100       110
                ....*....|....*....|....*....|...
gi 15596533 588 LGLTLSASLATAAGGSLSVqHPESGGTAFELSL 620
Cdd:cd16918  77 LGLAIAQNIVSQHGGVIEC-DSQPGHTVFSVSL 108
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
415-627 1.14e-14

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 76.60  E-value: 1.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  415 IAHELNQPLAALRtlsgNTVRFLQRG--KLETASTN-----LATINELVDRMGRITASLR-AFARRSDdagqaslakAVD 486
Cdd:PRK10549 247 ISHELRTPLAVLR----GELEAIQDGvrKFTPESVAslqaeVGTLTKLVDDLHQLSLSDEgALAYRKT---------PVD 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  487 AALLIL------HGRLEQDPPTLHRHFDD-VRLGIDQTRLEQILVNLLANALDAMSGQAdrQLWLEGRREEERYVLRVRD 559
Cdd:PRK10549 314 LVPLLEvaggafRERFASRGLTLQLSLPDsATVFGDPDRLMQLFNNLLENSLRYTDSGG--SLHISAEQRDKTLRLTFAD 391

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596533  560 NGPGIPPAARVHLFEPFFTTKPGEH----GLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSLSLVPDSP 627
Cdd:PRK10549 392 SAPGVSDEQLQKLFERFYRTEGSRNrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQ 463
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 519-620 1.16e-14

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 70.49  E-value: 1.16e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLANALDAMsgQADRQLWLEGRRE--------------EERYV-LRVRDNGPGIPPAARVHLFEPFFTTKPGE 583
Cdd:cd16919   1 LELAILNLAVNARDAM--PEGGRLTIETSNQrvdadyalnyrdliPGNYVcLEVSDTGSGMPAEVLRRAFEPFFTTKEVG 78

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15596533 584 HGLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSL 620
Cdd:cd16919  79 KGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 515-620 4.05e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 66.02  E-value: 4.05e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 515 DQTRLEQILVNLLANALDAMSGQADRQLWLEGRRE---EERYVLRVRDNGPGIPPAARVHLFEPFFTTKPgeHGLGLGLT 591
Cdd:cd16944   1 DTTQISQVLTNILKNAAEAIEGRPSDVGEVRIRVEadqDGRIVLIVCDNGKGFPREMRHRATEPYVTTRP--KGTGLGLA 78

                        90       100
                ....*....|....*....|....*....
gi 15596533 592 LSASLATAAGGSLSVQHPESGGTAFELSL 620
Cdd:cd16944  79 IVKKIMEEHGGRISLSNREAGGACIRIIL 107
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 515-620 3.75e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 63.25  E-value: 3.75e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 515 DQTRLEQILVNLLANALDAMsgQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEH----GLGLGL 590
Cdd:cd16946   1 DRDRLQQLFVNLLENSLRYT--DTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrasgGSGLGL 78

                        90       100       110
                ....*....|....*....|....*....|
gi 15596533 591 TLSASLATAAGGSLSVQHPESGGTAFELSL 620
Cdd:cd16946  79 AICHNIALAHGGTISAEHSPLGGLRLVLTL 108
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 450-615 1.81e-11

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 66.85  E-value: 1.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533   450 ATINELVDRMGRITASLRAFARRSDDAGQASLAKAV-------DAALLILHGRLEQD------PPTLHRHFDDV------ 510
Cdd:TIGR02938 282 AAIHRLQGPMNLISAAISVLQRRGDDAGNPASAAMLqqalsagREHMEALRQVIPQSpqeivvPVNLNQILRDVitlstp 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533   511 RL---GI---------------DQTRLEQILVNLLANALDAMS--GQADRQLWLEGRREEERYVLRVRDNGPGIPPAARV 570
Cdd:TIGR02938 362 RLlaaGIvvdwqpaatlpailgRELQLRSLFKALVDNAIEAMNikGWKRRELSITTALNGDLIVVSILDSGPGIPQDLRY 441

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 15596533   571 HLFEPFFTTKPG-EHGLGLGLTLSASLATAAGGSLSVQHPESGGTA 615
Cdd:TIGR02938 442 KVFEPFFTTKGGsRKHIGMGLSVAQEIVADHGGIIDLDDDYSEGCR 487
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 338-618 1.38e-10

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 64.08  E-value: 1.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  338 ERRKVLAT-----RLAAREALQRANGELEVKIAERTADLQASnarLTAEIHERQQAEDTLRkaqdelvqagklavigqms 412
Cdd:PRK15053 286 KRQDVVANfnglsVIANREAIRSGDDLLGAIISFRSKDEIST---LNAQLTQIKQYVESLR------------------- 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  413 tSIAHElnqPLAALRTLSGntvrFLQRGK----LETASTNLATINELVDrmgritaSLR-AFARRSDDA---GQASLAKA 484
Cdd:PRK15053 344 -TLRHE---HLNWMSTLNG----LLQMKEydrvLEMVQGESQAQQQLID-------SLReAFADRQVAGllfGKVQRARE 408

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  485 VDAALLILHG-RLEQDPPtlhrhfddvrlGIDQTRLEQILVNLLANALDA--MSGQADRQLWLEGRREEERYVLRVRDNG 561
Cdd:PRK15053 409 LGLKMVIVPGsQLSQLPP-----------GLDSTEFAAIVGNLLDNAFEAslRSDEGNKIVELFLSDEGDDVVIEVADQG 477

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  562 PGIPPAARVHLFEPFFTTK---PGEHGLGLGLTlsASLATAAGGSLSVQHPESGGTAFEL 618
Cdd:PRK15053 478 CGVPESLRDKIFEQGVSTRadePGEHGIGLYLI--ASYVTRCGGVITLEDNDPCGTLFSI 535
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 515-620 2.44e-10

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 57.89  E-value: 2.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 515 DQTRLEQILVNLLANALDAM-SGQADRQLWLEGRreEERYVLRVRDNGPGIPPAARVHLFEPFFTTKpGEH-----GLGL 588
Cdd:cd16925   1 DAEKYERVVLNLLSNAFKFTpDGGRIRCILEKFR--LNRFLLTVSDSGPGIPPNLREEIFERFRQGD-GSStrahgGTGL 77

                        90       100       110
                ....*....|....*....|....*....|..
gi 15596533 589 GLTLSASLATAAGGSLSVQHPESGGTAFELSL 620
Cdd:cd16925  78 GLSIVKEFVELHGGTVTVSDAPGGGALFQVEL 109
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 519-613 4.07e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 57.07  E-value: 4.07e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLANALDAMSGQADRQLWLEGRReeerYVLRVRDNGPGIPPAARVHLFEPFFTTKP--GEHGLGLGLTLSASL 596
Cdd:cd16950   1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNR----TRIQVLDNGPGIAPEEVDELFQPFYRGDNarGTSGTGLGLAIVQRI 76

                        90
                ....*....|....*..
gi 15596533 597 ATAAGGSLSVQHPESGG 613
Cdd:cd16950  77 SDAHGGSLTLANRAGGG 93
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 522-620 4.52e-10

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 62.62  E-value: 4.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  522 ILVNLLANALDAMSGQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEHGLGLGLTLSA--SLata 599
Cdd:PRK11086 437 ILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSveNL--- 513

                         90       100
                 ....*....|....*....|.
gi 15596533  600 aGGSLSVQHPESGGTAFELSL 620
Cdd:PRK11086 514 -GGSIAVESEPGVGTQFFVQI 533
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 519-622 5.38e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 56.95  E-value: 5.38e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLANALDamsgQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFF------TTKPGehGLGLGLTL 592
Cdd:cd16949   1 LARALENVLRNALR----YSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESG--GTGLGLAI 74

                        90       100       110
                ....*....|....*....|....*....|
gi 15596533 593 SASLATAAGGSLSVQHPESGGtaFELSLSL 622
Cdd:cd16949  75 AERAIEQHGGKIKASNRKPGG--LRVRIWL 102
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 519-620 9.15e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 56.18  E-value: 9.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLANALDAMSGQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGE--HGLGLGLTLSASL 596
Cdd:cd16921   1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREeyEGTGVGLAIVRKI 80

                        90       100
                ....*....|....*....|....
gi 15596533 597 ATAAGGSLSVQHPESGGTAFELSL 620
Cdd:cd16921  81 IERHGGRIWLESEPGEGTTFYFTL 104
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 519-615 1.55e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 55.66  E-value: 1.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLANALdAMSGQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKP-----GEHGlGLGLTLS 593
Cdd:cd16953   1 LGQVLRNLIGNAI-SFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPaneafGQHS-GLGLSIS 78

                        90       100
                ....*....|....*....|..
gi 15596533 594 ASLATAAGGSLSVQHPESGGTA 615
Cdd:cd16953  79 RQIIEAHGGISVAENHNQPGQV 100
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 515-616 1.66e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 55.54  E-value: 1.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 515 DQTRLEQILVNLLANALDAMSGQADRQLWLEGRREEERyvLRVRDNGPGIPPAARVHLFEPFFT-TKP--GEHGLGLGLT 591
Cdd:cd16945   1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIE--LLVFDEGSGIPDYALNRVFERFYSlPRPhsGQKSTGLGLA 78

                        90       100
                ....*....|....*....|....*
gi 15596533 592 LSASLATAAGGSLSVQHPESGGTAF 616
Cdd:cd16945  79 FVQEVAQLHGGRITLRNRPDGVLAF 103
PRK10490 PRK10490
sensor protein KdpD; Provisional
 480-622 3.02e-09

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 60.05  E-value: 3.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  480 SLAKAVDAALLILHGRLEQDPPTLHRHFDDVRLGIDQTRLEQILVNLLANALDAMSGQAdrQLWLEGRREEERYVLRVRD 559
Cdd:PRK10490 740 TLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQA--EIGIDAHVEGERLQLDVWD 817

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596533  560 NGPGIPPAARVHLFEPFF-----TTKPgehGLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSLSL 622
Cdd:PRK10490 818 NGPGIPPGQEQLIFDKFArgnkeSAIP---GVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPL 882
envZ PRK09467
osmolarity sensor protein; Provisional
 522-624 3.39e-09

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 59.54  E-value: 3.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  522 ILVNLLANALDAMSGqadrqlWLE--GRREEERYVLRVRDNGPGIPPAARVHLFEPFFT--TKPGEHGLGLGLTLSASLA 597
Cdd:PRK09467 335 ALANLVVNAARYGNG------WIKvsSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRgdSARGSSGTGLGLAIVKRIV 408

                         90       100
                 ....*....|....*....|....*..
gi 15596533  598 TAAGGSLSVQHPESGGTAFELSLSLVP 624
Cdd:PRK09467 409 DQHNGKVELGNSEEGGLSARAWLPLTT 435
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 515-614 3.53e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 54.72  E-value: 3.53e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 515 DQTRLEQILVNLLANALdAMSGQADR-QLWLEGRREEeryVLRVRDNGPGIPPAARVHLFEPFFTTkPGEH--GLGLGLT 591
Cdd:cd16940  10 DALLLFLLLRNLVDNAV-RYSPQGSRvEIKLSADDGA---VIRVEDNGPGIDEEELEALFERFYRS-DGQNygGSGLGLS 84

                        90       100
                ....*....|....*....|...
gi 15596533 592 LSASLATAAGGSLSVQHPESGGT 614
Cdd:cd16940  85 IVKRIVELHGGQIFLGNAQGGGL 107
glnL PRK11073
nitrogen regulation protein NR(II);
384-596 7.49e-09

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 57.78  E-value: 7.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  384 ERQQAEDTLRKAQDelvQAGKLAVIGqmstsIAHELNQPLAALRtlsgNTVRFLQRGKLETASTNLATI--------NEL 455
Cdd:PRK11073 114 QRRLSQEQLQHAQQ---VAARDLVRG-----LAHEIKNPLGGLR----GAAQLLSKALPDPALTEYTKViieqadrlRNL 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  456 VDRM-------GRITASLRAFARRsddagqasLAKAVDaallilhgrLE-QDPPTLHRHFDDV--RLGIDQTRLEQILVN 525
Cdd:PRK11073 182 VDRLlgpqrpgTHVTESIHKVAER--------VVQLVS---------LElPDNVRLIRDYDPSlpELAHDPDQIEQVLLN 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  526 LLANALDAMSGQ---------ADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGehGLGLGLTLSASL 596
Cdd:PRK11073 245 IVRNALQALGPEggtitlrtrTAFQLTLHGERYRLAARIDIEDNGPGIPPHLQDTLFYPMVSGREG--GTGLGLSIARNL 322
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 321-620 1.36e-08

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 57.40  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533   321 LAAIGFALLAFLLIAWNERRKVLATRLAAREALQRANGELEVKIAErtadlqasnARLTAEIHERQQAEDTLRKAQDELV 400
Cdd:TIGR01386 168 LIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDP---------SRAPAELRELAQSFNAMLGRLEDAF 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533   401 QagKLAvigQMSTSIAHELNQPLAALrtLSGNTVRFLQRGKLETASTNLATINELVDRMGRITASLrAFARRSDDAgqas 480
Cdd:TIGR01386 239 Q--RLS---QFSADLAHELRTPLTNL--LGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDM-LFLARADNG---- 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533   481 lAKAVDAALLILHGRLEQDPPTLHRHFDDVRLGI----------DQTRLEQILVNLLANALDAMSgqADRQLWLEGRREE 550
Cdd:TIGR01386 307 -QLALERVRLDLAAELAKVAEYFEPLAEERGVRIrvegeglvrgDPQMFRRAISNLLSNALRHTP--DGGTITVRIERRS 383

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596533   551 ERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEH----GLGLGLTLSASLATAAGGSLSVQHPEsGGTAFELSL 620
Cdd:TIGR01386 384 DEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSnsgeGTGLGLAIVRSIMEAHGGRASAESPD-GKTRFILRF 456
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 519-620 1.95e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 52.90  E-value: 1.95e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLANALDamSGQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEH----GLGLGLTLSA 594
Cdd:cd16947  21 LQRILKNLISNAIK--YGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNsakqGNGLGLTITK 98

                        90       100
                ....*....|....*....|....*.
gi 15596533 595 SLATAAGGSLSVQHPESGGTAFELSL 620
Cdd:cd16947  99 RLAESMGGSIYVNSKPYEKTVFTVTL 124
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 77-627 5.94e-08

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 55.68  E-value: 5.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  77 YLPSLLELERSVSHLLTDPTPYRRNQVNAYLEGLNRRAGSRAVYLLDTNGRVLATSNWSDPDSYLGEDLSFRAYWQDAMK 156
Cdd:COG3920   6 LLLLLLALAALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALL 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 157 GKPGRFYGIGSTRGEPGYYLAHGLVHGGRIIGVAVVKVKMDALEERWEKARLEAFVSDENGIIILSSNPALRLKAVRSLS 236
Cdd:COG3920  86 VLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAE 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 237 ADDKERLARSMQYYWWALNEWQPLQREPLAAGVEKLSFPADEQHPRGEAVTYLAQTRALNDTPWNLTLLSPLEDLRRDAV 316
Cdd:COG3920 166 ELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRR 245

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 317 RNGMLAAIGFALLAFLLIAWNERRKVLATRLAAREaLQRANGELEVKIAERTAdlqasnarLTAEIHERqqaedtlrkaq 396
Cdd:COG3920 246 RARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITE-RKRAEEELEASLEEKEL--------LLRELHHR----------- 305

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 397 delVqagK--LAVIgqmsTSIAHelnqpLAALRTLSGNTVRFLQ--RGKLETastnLATINELVdrmgritaslrafaRR 472
Cdd:COG3920 306 ---V---KnnLQVV----SSLLR-----LQARRADDPEAREALEesQNRIQA----LALVHELL--------------YQ 352

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 473 SDDAGQASLAKAVDAALLILHGRLEQDPPTLHRHFDDVRLGIDQ-TRLEQILVNLLANALD-AMSGQADRQLWLEGRREE 550
Cdd:COG3920 353 SEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVELPADAaVPLGLILNELVTNALKhAFLSGEGGRIRVSWRRED 432

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596533 551 ERYVLRVRDNGPGIPPAARVhlfepffttkpgEHGLGLGLTLSASLATAAGGSLSVQHPEsgGTAFELSLSLVPDSP 627
Cdd:COG3920 433 GRLRLTVSDNGVGLPEDVDP------------PARKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITFPLAELAA 495
PRK10337 PRK10337
sensor protein QseC; Provisional
 416-621 7.17e-08

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 55.04  E-value: 7.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  416 AHELNQPLAALRTLSgnTVRFLQRGKLETASTNLATINELVDRMGRITASLRAFAR-----RSDDAGQASLAKAVDAALL 490
Cdd:PRK10337 245 AHELRSPLAALKVQT--EVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRldsldNLQDVAEIPLEDLLQSAVM 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  491 ILHGRLEQDPPTLHRHFDD---VRLGidQTRLEQILV-NLLANALDAMSGQADRQLWLEGRReeeryvLRVRDNGPGIPP 566
Cdd:PRK10337 323 DIYHTAQQAGIDVRLTLNAhpvIRTG--QPLLLSLLVrNLLDNAIRYSPQGSVVDVTLNARN------FTVRDNGPGVTP 394

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 15596533  567 AARVHLFEPFFtTKPGEH--GLGLGLTLSASLATAAGGSLSVQHPESGGtaFELSLS 621
Cdd:PRK10337 395 EALARIGERFY-RPPGQEatGSGLGLSIVRRIAKLHGMNVSFGNAPEGG--FEAKVS 448
PDC1_DGC_like cd12914
first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this ...
 86-196 1.43e-07

first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the first PDC domain of Diguanylate-cyclases (DGCs), Histidine kinases (HKs), and other similar domains. Many members of this subfamily contain a C-terminal DGC (also called GGDEF) domain. DGCs regulate the turnover of cyclic diguanosine monophosphate. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.


Pssm-ID: 350339  Cd Length: 123  Bit Score: 50.46  E-value: 1.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  86 RSVSHLLTDPTPYRRN--QVNAYLEGLNRRAGS-RAVYLLDTNGRVLATSNwsdPDSYLGEDLSFRAYWQDAMKGKPGRF 162
Cdd:cd12914   9 RSLADDLEARGAASADpaALQALLRRLLARLPEvRSIFVVDADGRVVASSG---PGPAPGLDVSDRDYFQAARAGGGGLF 85

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15596533 163 YG---IGSTRGEPGYYLAHGLVH-GGRIIGVAVVKVKM 196
Cdd:cd12914  86 ISepvISRVTGKPVIPLSRPIRDaDGRFAGVVVASIDL 123
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
320-625 1.53e-07

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 53.08  E-value: 1.53e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 320 MLAAIGFALLAFLLIAWNERRKVLATRLAAREALQRAngelevKIAERtadlqasnARLTAEIHerqqaedtlrkaqDel 399
Cdd:COG4585  13 LVGALLGLLLALVLLRARRAERAAELERELAARAEEA------REEER--------RRIARELH-------------D-- 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 400 vqagklaVIGQMSTSIAHELNqplAALRTLSGNTvrflqrgklETASTNLATINELVDRmgrITASLRAFAR--RSDDAG 477
Cdd:COG4585  64 -------GVGQSLSAIKLQLE---AARRLLDADP---------EAAREELEEIRELARE---ALAELRRLVRglRPPALD 121

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 478 QASLAKAVDAaLLILHGRLEQDPPTLHRHFDDVRLGIDQTR-LEQILVNLLANAL---DAmsgqadRQLWLEGRREEERY 553
Cdd:COG4585 122 DLGLAAALEE-LAERLLRAAGIRVELDVDGDPDRLPPEVELaLYRIVQEALTNALkhaGA------TRVTVTLEVDDGEL 194

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596533 554 VLRVRDNGPGIPPAARVhlfepffttkpgehGLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSLSLVPD 625
Cdd:COG4585 195 TLTVRDDGVGFDPEAAP--------------GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 508-620 1.80e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 50.32  E-value: 1.80e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 508 DDVRLGIDQTRLEQILVNLLANALDamsgQADRQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFE---PFFTTKPGEh 584
Cdd:cd16954  27 PELRFPGERNDLMELLGNLLDNACK----WCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQrgqRLDEQRPGQ- 101

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15596533 585 glGLGLTLSASLATAAGGSLSVQHPESGGTAFELSL 620
Cdd:cd16954 102 --GLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 519-621 2.38e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 49.59  E-value: 2.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 519 LEQILVNLLAnaldaMSGQADrQLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEHGL---GLGLTLSAS 595
Cdd:cd16948  10 IGQIVSNALK-----YSKQGG-KIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQestGMGLYLVKK 83

                        90       100
                ....*....|....*....|....*.
gi 15596533 596 LATAAGGSLSVQHPESGGTAFELSLS 621
Cdd:cd16948  84 LCDKLGHKIDVESEVGEGTTFTITFP 109
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
515-622 3.44e-07

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 53.44  E-value: 3.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  515 DQTRLEQILVNLLANALD-AMSGQadrqLWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGE----HGLGLG 589
Cdd:PRK10841 559 DPMRLQQVISNLLSNAIKfTDTGC----IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVqrnfQGTGLG 634

                         90       100       110
                 ....*....|....*....|....*....|...
gi 15596533  590 LTLSASLATAAGGSLSVQHPESGGTAFELSLSL 622
Cdd:PRK10841 635 LAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 382-620 4.27e-07

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 53.02  E-value: 4.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  382 IHERQQAEDTLRKAQDElvqagKLAVIgqmSTsIAHELNQPLAALRTLSgntvRFL--------QRGKLET----ASTnL 449
Cdd:PRK11091 266 ITERKRYQDALEKASRD-----KTTFI---ST-ISHELRTPLNGIVGLS----RILldteltaeQRKYLKTihvsAIT-L 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  450 ATI-NELV--DRMGRitaslrafaRRSDDAGQASLAKAVDAALLILHGRLEQdPPTLHRHFDdvRLG-------IDQTRL 519
Cdd:PRK11091 332 GNIfNDIIdmDKMER---------RKLQLDNQPIDFTDFLADLENLSGLQAE-QKGLRFDLE--PLLplphkviTDGTRL 399

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  520 EQILVNLLANALD-AMSGQADRQLWLEgrrEEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEHGL-----GLGLTLS 593
Cdd:PRK11091 400 RQILWNLISNAVKfTQQGGVTVRVRYE---EGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKpatgtGIGLAVS 476

                        250       260
                 ....*....|....*....|....*..
gi 15596533  594 ASLATAAGGSLSVQHPESGGTAFELSL 620
Cdd:PRK11091 477 KRLAQAMGGDITVTSEEGKGSCFTLTI 503
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
497-622 1.22e-06

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 47.99  E-value: 1.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 497 EQDPPTLHRHFDDV--RLGIDQTRLEQIL--VN-LLANALD-AMSGQADRQLWLEGRREEERYVLRVRDNGPGIPPAarv 570
Cdd:COG2172   8 LEDLGLARRAVRALlrELGLDEDDADDLVlaVSeAVTNAVRhAYGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPE--- 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15596533 571 HLFEPFFTTKPGehglGLGLTLSASLATaaggSLSVqHPESGGTAFELSLSL 622
Cdd:COG2172  85 DLPDPYSTLAEG----GRGLFLIRRLMD----EVEY-ESDPGGTTVRLVKRL 127
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 409-471 9.60e-06

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 43.74  E-value: 9.60e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596533   409 GQMSTSIAHELNQPLAALRTlsgnTVRFLQRGKL-ETASTNLATINELVDRMGRITASLRAFAR 471
Cdd:pfam00512   3 SEFLANLSHELRTPLTAIRG----YLELLRDEKLdEEQREYLETILRSAERLLRLINDLLDLSR 62
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 405-471 4.58e-05

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 41.43  E-value: 4.58e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596533 405 LAVIGQMSTSIAHELNQPLAALRTLSGNTVRFLQRGklETASTNLATINELVDRMGRITASLRAFAR 471
Cdd:cd00082   1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDD--EEQREYLERIREEAERLLRLINDLLDLSR 65
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 515-613 8.26e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 42.06  E-value: 8.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 515 DQTRLEQILVNLLANALDAMSGQADRQLWLEGRREEERYVlrVRDNGPGIPPAARVHLFEPFFTTKPGEHG---LGLGLT 591
Cdd:cd16975   1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFE--IWDNGHGFSEQDLKKALELFYRDDTSRRSgghYGMGLY 78

                        90       100
                ....*....|....*....|..
gi 15596533 592 LSASLATAAGGSLSVQHPESGG 613
Cdd:cd16975  79 IAKNLVEKHGGSLIIENSQKGG 100
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 409-471 1.09e-04

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 40.63  E-value: 1.09e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596533    409 GQMSTSIAHELNQPLAALRTlsgnTVRFLQRGKL-ETASTNLATINELVDRMGRITASLRAFAR 471
Cdd:smart00388   3 REFLANLSHELRTPLTAIRG----YLELLLDTELsEEQREYLETILREAERLLRLINDLLDLSR 62
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
185-588 2.19e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 44.24  E-value: 2.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 185 RIIGVAVVKVKMDALEERWEKARLEAFVSDENGIIILSSNPALRLKAVRSLSADDKERLARSMQYYWWALNEWQPLQREP 264
Cdd:COG2972  22 LLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSLLL 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 265 LAAGVEKLSFPADEQHPRGEAVTYLAQTRALNDTPWNLTLLSPLEDLRRDA--VRNGMLAAIGFALLAFLLIAWNERRKV 342
Cdd:COG2972 102 LLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLfsLRRLILLIILLLLLLALLLSYLLSRSI 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 343 LATRLAAREALQRANGELEVKIAERTAD--------LQASNARLTAEIHERQQAEDTLRKAQDELVQAgklavigQMSts 414
Cdd:COG2972 182 TRPIKRLKKAMKKVEKGDLVRLEVSGNDeigilarsFNEMVERIKELIEEVYELELEKKEAELKALQA-------QIN-- 252

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 415 iAHEL-NqplaalrTLsgNTVRFLQRGKletastNLATINELVDRMGRItasLRAFARRSDDAgqASLAKAVDAA---LL 490
Cdd:COG2972 253 -PHFLfN-------TL--NSIRWLAELE------DPEEAEEMLEALSKL---LRYSLSKGDEL--VTLEEELELIksyLE 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 491 ILHGRLEQDpptLHRHFDdvrlgIDQTRLE--------QILVNllaNA----LDAMSGQAdrQLWLEGRREEERYVLRVR 558
Cdd:COG2972 312 IQKLRFGDR---LEVEIE-----IDEELLDllipklilQPLVE---NAiehgIEPKEGGG--TIRISIRKEGDRLVITVE 378

                       410       420       430
                ....*....|....*....|....*....|
gi 15596533 559 DNGPGIPPAARVHLFEPfFTTKPGEHGLGL 588
Cdd:COG2972 379 DNGVGMPEEKLEKLLEE-LSSKGEGRGIGL 407
PDC1_HK_sensor cd18773
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase ...
 80-192 2.46e-04

first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase and similar domains; Histidine kinase (HK) receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. HK receptors in this family contain double PDC (PhoQ/DcuS/CitA) sensor domains. Signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses. The HK family includes not just histidine kinase receptors but also sensors for chemotaxis proteins and diguanylate cyclase receptors, implying a combinatorial molecular evolution.


Pssm-ID: 350341 [Multi-domain]  Cd Length: 125  Bit Score: 41.39  E-value: 2.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  80 SLLELERSVSHLLTDPTPYRRNQVNAYLEGLNRRAGS-RAVYLLDTNGRVLATSNWSDPDSYLGEDLSFRAYWQDAMKGK 158
Cdd:cd18773   6 LLLRSLASALEALAALGSADREELQALLRRLLERNPEiSGIYVVDADGRVVASSDRDPGGGDDDDDRDRFWYQAAKATGK 85

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15596533 159 P--GRFYgIGSTRGEPGYYLAHGLVH-GGRIIGVAVV 192
Cdd:cd18773  86 LviSEPY-ISRVTGKPVITLSRPIRDaDGRFIGVVGA 121
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
415-614 4.06e-04

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 43.03  E-value: 4.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  415 IAHELNQPLAALRtLSgntVRFLQRGKLETASTNLATInelvDRMGRITASLRAFARrsddAGQASLA------KAVDAA 488
Cdd:PRK10755 144 VAHELRTPLAGIR-LH---LELLEKQHHIDVAPLIARL----DQMMHTVEQLLQLAR----AGQSFSSghyqtvKLLEDV 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  489 LLILHGRLE------QDPPTLHRHFDDVRLGIDQTRLEQILVNLLANALDAMSGQADRQLWLEgrREEERYVLRVRDNGP 562
Cdd:PRK10755 212 ILPSQDELSemleqrQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLS--QEDGGAVLAVEDEGP 289

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 15596533  563 GIPPAARVHLFEPFFTTKPGEHGLGLGLTLSASLATAAGGSLSVQ-HPESGGT 614
Cdd:PRK10755 290 GIDESKCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQFFLQnRQERSGT 342
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
508-620 2.20e-03

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 41.26  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533   508 DDVRLGIDQTRLEQILVNLLANALDAMSGQADRQLWLEGRREEERYVLR--VRDNGPGIPPAARVHLFEPFFTTKPGEH- 584
Cdd:PRK09959  818 DHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSLGHIDDNHAVIKmtIMDSGSGLSQEEQQQLFKRYSQTSAGRQq 897

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 15596533   585 -GLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSL 620
Cdd:PRK09959  898 tGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITI 934
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 550-620 2.50e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 37.53  E-value: 2.50e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596533 550 EERYVLRVRDNGPGIPPAARvhlfepffttkpgEHGLGLGLTLSASLATAAGGSLSVQHPESGGTAFELSL 620
Cdd:cd16917  29 ADELTLTVVDDGVGFDGPAP-------------PGGGGFGLLGMRERAELLGGTLTIGSRPGGGTRVTARL 86
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 515-624 2.92e-03

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 40.99  E-value: 2.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533  515 DQTRLEQILVNLLANALD-AMSGQADrqLWLEGRREEERYVL---RVRDNGPGIPPAARVHLFEPF------FTTKPGeh 584
Cdd:PRK11107 405 DPLRLQQIITNLVGNAIKfTESGNID--ILVELRALSNTKVQlevQIRDTGIGISERQQSQLFQAFrqadasISRRHG-- 480

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 15596533  585 GLGLGLTLSASLATAAGGSLSVQ-HPESGGT-AFELSLSLVP 624
Cdd:PRK11107 481 GTGLGLVITQKLVNEMGGDISFHsQPNRGSTfWFHLPLDLNP 522
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 303-520 3.94e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.43  E-value: 3.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533    303 TLLSPLEDLRRDAVRNGMLAAIGFALLAFLLIAWNERRKVLATRLAAreaLQRANGELEVKIAERTADLQASNARLTAEI 382
Cdd:TIGR02168  705 KELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQ---LSKELTELEAEIEELEERLEEAEEELAEAE 781

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533    383 HERQQAEDTLRKAQDELVQagklavigqmSTSIAHELNQPLAALRTLSGNTVRFLQRGKLETASTNlATINELVDRMGRI 462
Cdd:TIGR02168  782 AEIEELEAQIEQLKEELKA----------LREALDELRAELTLLNEEAANLRERLESLERRIAATE-RRLEDLEEQIEEL 850

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533    463 TASLrAFARRSDDAGQASLAKAVDA--ALLILHGRLEQDPPTLHRHFDDVRLGIDQTRLE 520
Cdd:TIGR02168  851 SEDI-ESLAAEIEELEELIEELESEleALLNERASLEEALALLRSELEELSEELRELESK 909
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 495-614 5.63e-03

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 38.09  E-value: 5.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596533 495 RLEQDPPtlhRHFDDVrlgidQTRLEQILVNLLANALDA-MSGQADRQLWLEG-----RREEERYVLRVRDNGPGIPPAA 568
Cdd:cd16929  28 EIEGDPS---IRFPYV-----PSHLYYILFELLKNAMRAtVESHGDDSDDLPPikvtvAKGDEDLTIKISDRGGGIPRED 99

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15596533 569 RVHLFEPFFTTKPGE-----------------HGLGLGLTLSASLATAAGGSLSVQHPESGGT 614
Cdd:cd16929 100 LARLFSYMYSTAPQPslddfsdlisgtqpsplAGFGYGLPMSRLYAEYFGGDLDLQSMEGYGT 162
PRK04184 PRK04184
DNA topoisomerase VI subunit B; Validated
 526-566 9.92e-03

DNA topoisomerase VI subunit B; Validated


Pssm-ID: 235246 [Multi-domain]  Cd Length: 535  Bit Score: 38.72  E-value: 9.92e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 15596533  526 LLANALDAmsgqADR-----QLWLEGRRE---EERYVLRVRDNGPGIPP 566
Cdd:PRK04184  44 LVDNSLDA----CEEagilpDIKIEIKRVdegKDHYRVTVEDNGPGIPP 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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