NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15596664|ref|NP_250158|]
View 

hypothetical protein PA1467 [Pseudomonas aeruginosa PAO1]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 11457199)

helix-turn-helix (HTH) transcriptional regulator containing DNA-binding HTH and WYL domains, may function in the regulation of DNA damage response and bacterial immunity

Gene Ontology:  GO:0003677|GO:0003700|GO:0006355
PubMed:  24817877|37027901|15808743|10473770|8831795

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 3-315 4.62e-74

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


:

Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 230.74  E-value: 4.62e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596664   3 KPTVRVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIPISAERGRHGGYRLVAGFKLPPLMFSAEETLAV 82
Cdd:COG2378   2 SRLERLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRELGVPIEAERGRGGGYRLRDGYRLPPLMLTEEEALAL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596664  83 SLGLLAVRSLGLGESELALESAQAKLSRVMPVALRRRLVALRETASLDLARARAGTSVAALATLAEAaqvRARVEFRYRD 162
Cdd:COG2378  82 LLALRLLAALGGAPLAEAAASALAKLEAVLPERLRERLEALAERVGVDPPPEVDPEVLETLREAIRE---RRRLRIDYRS 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596664 163 PQGAETLRQLDPYGLAYRNGCWYVSGFCHLRQALRSFRLDRLDAPRMLAERFERPADFDTLRHLRES---FARMPRAYPV 239
Cdd:COG2378 159 GRGEPTERTVEPYGLVFYGGRWYLVAWCELRDDIRTFRLDRIRSLELTDERFEPPPDFDLAEYLAEGfgvFAGGPEPVTV 238

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596664 240 EILMRAAREQVVAVLGEPLGLLAEVDGGTLLRASTDDLDWFARRLCGLPFDFEVRQPLELREPLRRQAERVLRNLG 315
Cdd:COG2378 239 TLRFSPEAARYLRERHPSQEIEELPDGSVRVTLTVADLDELARWLLSFGADVEVLEPEELREAVREEARRLLARYE 314
 
Name Accession Description Interval E-value
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 3-315 4.62e-74

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 230.74  E-value: 4.62e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596664   3 KPTVRVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIPISAERGRHGGYRLVAGFKLPPLMFSAEETLAV 82
Cdd:COG2378   2 SRLERLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRELGVPIEAERGRGGGYRLRDGYRLPPLMLTEEEALAL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596664  83 SLGLLAVRSLGLGESELALESAQAKLSRVMPVALRRRLVALRETASLDLARARAGTSVAALATLAEAaqvRARVEFRYRD 162
Cdd:COG2378  82 LLALRLLAALGGAPLAEAAASALAKLEAVLPERLRERLEALAERVGVDPPPEVDPEVLETLREAIRE---RRRLRIDYRS 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596664 163 PQGAETLRQLDPYGLAYRNGCWYVSGFCHLRQALRSFRLDRLDAPRMLAERFERPADFDTLRHLRES---FARMPRAYPV 239
Cdd:COG2378 159 GRGEPTERTVEPYGLVFYGGRWYLVAWCELRDDIRTFRLDRIRSLELTDERFEPPPDFDLAEYLAEGfgvFAGGPEPVTV 238

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596664 240 EILMRAAREQVVAVLGEPLGLLAEVDGGTLLRASTDDLDWFARRLCGLPFDFEVRQPLELREPLRRQAERVLRNLG 315
Cdd:COG2378 239 TLRFSPEAARYLRERHPSQEIEELPDGSVRVTLTVADLDELARWLLSFGADVEVLEPEELREAVREEARRLLARYE 314
WYL pfam13280
WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the ...
 155-311 4.76e-32

WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.


Pssm-ID: 433082  Cd Length: 172  Bit Score: 117.37  E-value: 4.76e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596664   155 RVEFRYRDPQGAETLRQLDPYGLAYRNGCWYVSGFCHLRQALRSFRLDRLDAPRMLAERFERPaDFDTLRHLRESFARMP 234
Cdd:pfam13280  15 RVRFRYRSPRGEGTERTVEPYGLVYKDGRWYLVAYCRLRDDIRTFRLDRIESVEVLDEPFEPP-DFDLAEYLRRSFGVFP 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596664   235 RAYPVEILMRA-AREQVVAVLGEPLGLLAEVDGGTL-LRASTDDLDWFARRLCGLPFDFEVRQPLELREPLRRQAERVL 311
Cdd:pfam13280  94 GPIEVKLRFSPeAARRLRERRFPDQQIEEEDDDGSLrVTLPVDDLEELARWLLSFGPDVEVLEPPELREEVREEAKRLL 172
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
7-63 1.63e-04

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 38.74  E-value: 1.63e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 15596664      7 RVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIPISAergrHGGYRL 63
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRV----HGGAVS 53
PRK11886 PRK11886
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA;
3-69 2.31e-04

bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA;


Pssm-ID: 237010 [Multi-domain]  Cd Length: 319  Bit Score: 42.47  E-value: 2.31e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596664    3 KPTVRVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIPISAERGRhgGYRLVAGFKL 69
Cdd:PRK11886   1 KTYTVMLQLLSLLADGDFHSGEQLGEELGISRAAIWKHIQTLEEWGLDIFSVKGK--GYRLAEPLDL 65
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 2-49 7.32e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 36.95  E-value: 7.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 15596664     2 SKPTVRVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGI 49
Cdd:TIGR01884 139 AGLSREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGL 186
 
Name Accession Description Interval E-value
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 3-315 4.62e-74

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 230.74  E-value: 4.62e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596664   3 KPTVRVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIPISAERGRHGGYRLVAGFKLPPLMFSAEETLAV 82
Cdd:COG2378   2 SRLERLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRELGVPIEAERGRGGGYRLRDGYRLPPLMLTEEEALAL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596664  83 SLGLLAVRSLGLGESELALESAQAKLSRVMPVALRRRLVALRETASLDLARARAGTSVAALATLAEAaqvRARVEFRYRD 162
Cdd:COG2378  82 LLALRLLAALGGAPLAEAAASALAKLEAVLPERLRERLEALAERVGVDPPPEVDPEVLETLREAIRE---RRRLRIDYRS 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596664 163 PQGAETLRQLDPYGLAYRNGCWYVSGFCHLRQALRSFRLDRLDAPRMLAERFERPADFDTLRHLRES---FARMPRAYPV 239
Cdd:COG2378 159 GRGEPTERTVEPYGLVFYGGRWYLVAWCELRDDIRTFRLDRIRSLELTDERFEPPPDFDLAEYLAEGfgvFAGGPEPVTV 238

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596664 240 EILMRAAREQVVAVLGEPLGLLAEVDGGTLLRASTDDLDWFARRLCGLPFDFEVRQPLELREPLRRQAERVLRNLG 315
Cdd:COG2378 239 TLRFSPEAARYLRERHPSQEIEELPDGSVRVTLTVADLDELARWLLSFGADVEVLEPEELREAVREEARRLLARYE 314
WYL pfam13280
WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the ...
 155-311 4.76e-32

WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.


Pssm-ID: 433082  Cd Length: 172  Bit Score: 117.37  E-value: 4.76e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596664   155 RVEFRYRDPQGAETLRQLDPYGLAYRNGCWYVSGFCHLRQALRSFRLDRLDAPRMLAERFERPaDFDTLRHLRESFARMP 234
Cdd:pfam13280  15 RVRFRYRSPRGEGTERTVEPYGLVYKDGRWYLVAYCRLRDDIRTFRLDRIESVEVLDEPFEPP-DFDLAEYLRRSFGVFP 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596664   235 RAYPVEILMRA-AREQVVAVLGEPLGLLAEVDGGTL-LRASTDDLDWFARRLCGLPFDFEVRQPLELREPLRRQAERVL 311
Cdd:pfam13280  94 GPIEVKLRFSPeAARRLRERRFPDQQIEEEDDDGSLrVTLPVDDLEELARWLLSFGPDVEVLEPPELREEVREEAKRLL 172
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 11-61 2.12e-12

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 60.91  E-value: 2.12e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15596664    11 LLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIPISAERGRhgGY 61
Cdd:pfam08279   4 LQLLLEARGPISGQELAEKLGVSRRTIRRDIKILEELGVPIEAEPGR--GY 52
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 6-63 2.89e-05

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 42.92  E-value: 2.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15596664     6 VRVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIpISAERGRHGGYRL 63
Cdd:pfam02082   9 LHALLYLALHPGGEPVTSEEIAERQNISPVYLEKILAKLRKAGL-VESVRGAGGGYRL 65
HTH_PafC pfam19187
PafC helix-turn-helix domain; This entry is an N-terminal HTH domain found in the PafC protein. ...
 6-110 9.68e-05

PafC helix-turn-helix domain; This entry is an N-terminal HTH domain found in the PafC protein. Transcriptional activator PafBC is responsible for upregulating the majority of genes induced by DNA damage.


Pssm-ID: 465990 [Multi-domain]  Cd Length: 115  Bit Score: 41.00  E-value: 9.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596664     6 VRVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIP---------ISAERGRHGGYRLVAGFKlpPLMFSA 76
Cdd:pfam19187   4 ARLLDLVPYLRQHPGVSVAEAAARFGVTPAQLRADLDVLFVCGLPgyypgdlidVDWEEGRVSITNADGLAR--PLRLTP 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 15596664    77 EETLAVSLGLLAVRSLGLGESELALESAQAKLSR 110
Cdd:pfam19187  82 AEAAALLLGLRALAALPGLADAEAVDSALAKLRA 115
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
7-63 1.63e-04

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 38.74  E-value: 1.63e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 15596664      7 RVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIPISAergrHGGYRL 63
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRV----HGGAVS 53
IscR COG1959
DNA-binding transcriptional regulator, IscR family [Transcription];
6-63 2.29e-04

DNA-binding transcriptional regulator, IscR family [Transcription];


Pssm-ID: 441562  Cd Length: 141  Bit Score: 40.59  E-value: 2.29e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15596664   6 VRVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIpISAERGRHGGYRL 63
Cdd:COG1959  10 LRALLYLALHPGGEPVTSKEIAERQGISPSYLEKILQKLRKAGL-VESVRGPGGGYRL 66
PRK11886 PRK11886
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA;
3-69 2.31e-04

bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA;


Pssm-ID: 237010 [Multi-domain]  Cd Length: 319  Bit Score: 42.47  E-value: 2.31e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596664    3 KPTVRVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIPISAERGRhgGYRLVAGFKL 69
Cdd:PRK11886   1 KTYTVMLQLLSLLADGDFHSGEQLGEELGISRAAIWKHIQTLEEWGLDIFSVKGK--GYRLAEPLDL 65
BirA COG1654
Biotin operon repressor [Transcription];
9-69 2.37e-04

Biotin operon repressor [Transcription];


Pssm-ID: 441260 [Multi-domain]  Cd Length: 324  Bit Score: 42.28  E-value: 2.37e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596664   9 LALLELLQSHGQLSGSELARRLEVdGRT-LRRYIVALEELGIPISAERGRhgGYRLVAGFKL 69
Cdd:COG1654   7 LKLLRLLADGEFHSGEELAEELGV-SRAaVWKHIKALRELGYEIESVPGK--GYRLAEPPDL 65
BglG COG3711
Transcriptional antiterminator [Transcription];
11-63 3.29e-04

Transcriptional antiterminator [Transcription];


Pssm-ID: 442925 [Multi-domain]  Cd Length: 618  Bit Score: 42.15  E-value: 3.29e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15596664  11 LLELLQSHGQLSGSELARRLEVDGRTLRRYIVA----LEELGIPISAERGRhgGYRL 63
Cdd:COG3711   2 LKILLKNNNVVTAKELAKKLNVSERTIRYDIKKinewLKKNGLEIISKKGI--GFRL 56
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
7-64 4.10e-04

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 38.01  E-value: 4.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15596664     7 RVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIPISAergrHGGYRLV 64
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRT----HGGAVSN 54
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 4-66 4.11e-04

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 41.27  E-value: 4.11e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15596664   4 PTVRVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIpisAERgRHGGYRLVAG 66
Cdd:COG1349   3 AEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGL---LRR-VHGGAVLVSS 61
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
9-49 1.57e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 35.87  E-value: 1.57e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15596664     9 LALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGI 49
Cdd:pfam13412   4 RKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGV 44
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 9-49 3.48e-03

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 36.72  E-value: 3.48e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15596664      9 LALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGI 49
Cdd:smart00344   6 RKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGV 46
srlR PRK10434
DNA-binding transcriptional repressor;
3-60 6.05e-03

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 37.74  E-value: 6.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15596664    3 KPTVRVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIPISaergRHGG 60
Cdd:PRK10434   2 KPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIR----TYGG 55
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
9-49 7.27e-03

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 36.29  E-value: 7.27e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15596664   9 LALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGI 49
Cdd:COG1522   8 RRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGV 48
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 2-49 7.32e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 36.95  E-value: 7.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 15596664     2 SKPTVRVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGI 49
Cdd:TIGR01884 139 AGLSREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGL 186
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
10-48 8.69e-03

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 37.29  E-value: 8.69e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 15596664   10 ALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELG 48
Cdd:PRK13509   9 ILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESG 47
COG4190 COG4190
Predicted transcriptional regulator, contains HTH domain [Transcription];
5-57 9.43e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443344  Cd Length: 121  Bit Score: 35.64  E-value: 9.43e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 15596664   5 TVRVLALLELLQSHGQLSGSELARRLEVDGRTLRRYIVALEELGIPISAERGR 57
Cdd:COG4190  51 TPKRLELLRAIAEEGPESIRELARRLGRDVKNVHRDLKTLEELGLVELEEDGR 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH