|
Name |
Accession |
Description |
Interval |
E-value |
| Lig |
COG0272 |
NAD-dependent DNA ligase [Replication, recombination and repair]; |
1-786 |
0e+00 |
|
NAD-dependent DNA ligase [Replication, recombination and repair];
Pssm-ID: 440042 [Multi-domain] Cd Length: 668 Bit Score: 1128.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 1 MTDTQAAaERIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPTQRVSGTPASAFGEVRHEI 80
Cdd:COG0272 1 MTPEEAK-ERIEELREELRRHNYRYYVLDAPEISDAEYDALLRELQALEAEHPELITPDSPTQRVGGAPLEGFAKVRHAV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 81 PMLSLGNAFEEQDLLDFDRRVREGLadllpggdllgGGAEVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITS 160
Cdd:COG0272 80 PMLSLDNAFSEEELRDFDRRVRKFL-----------GDEPVEYVCELKIDGLAISLRYENGRLVRAATRGDGTVGEDVTA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 161 NVRTIRNVPLKLHGEGWPEILEVRGEVFMSKAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGF 240
Cdd:COG0272 149 NVRTIRSIPLRLKGDDVPEVLEVRGEVYMPKADFEALNEEREEAGEKPFANPRNAAAGSLRQLDPKITAKRPLDFFAYGL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 241 GQVSGTLPDTQVGILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPR 320
Cdd:COG0272 229 GEVEGLLPDTQSEALELLKEWGFPVNPERRVCKSIEEVLAYIEEWEEKRHSLPYEIDGVVIKVNDLALQERLGFTSRAPR 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 321 WAIAHKFPAREELTELLGVEFQVGRTGAVTPVARLKPVQVAGVTVSNATLHNMDEVARLGLRIGDTVVIRRAGDVIPQVM 400
Cdd:COG0272 309 WAIAYKFPAEEATTKLLDIEVQVGRTGALTPVARLEPVFVAGVTVSRATLHNEDEIERKDVRIGDTVVVRKAGDVIPEVV 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 401 QVVLERRPADAQAIEVPEHCPVCGSAVERtqlvkrskgkesISEGAIYRCVGRLSCQAQLKQAIIHFVSRRAMDIDGLGD 480
Cdd:COG0272 389 GVVLEKRPGDEKPFVMPTHCPVCGSPLVR------------EEGEAALRCTNGLSCPAQLKERLKHFASRKAMDIEGLGE 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 481 KIVEQLVDRGLVASPADLYTLTYEQVFELEGFAELSTNNLLTAIADSRKPSLARFIFALGIPDVGEETAKLLARSLGSLE 560
Cdd:COG0272 457 KLIEQLVDAGLVKDPADLYRLTKEDLLGLERMGEKSAQNLLAAIEKSKKTPLARFLFALGIRHVGETTAKLLARHFGSLD 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 561 RIGKALPEVLTYLPDVGAEVAYEIHNFFADEHNRQVIAQLRDAehGVQLQEEgevaaefaacaslagfidklnipfiaat 640
Cdd:COG0272 537 ALMAASEEELAAVDGIGPVVAESIVEFFAEPHNRELIERLRAA--GVNMEEE---------------------------- 586
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 641 gaeklasrfgsldgiiradwldlrqverlperaakslrdffdepanvqralaieaqlrefgmhwqsERKAVEGLPLAGQT 720
Cdd:COG0272 587 ------------------------------------------------------------------EAEAAADSPLAGKT 600
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596726 721 WVLTGTLEAMSRDVAKDKLEGLGAKVAGSVSAKTHCVVAGPGAGSKLAKANELGVKVLDEDGLLKL 786
Cdd:COG0272 601 FVLTGTLETMTRDEAKELIEALGGKVSGSVSKKTDYVVAGENAGSKLDKAEELGVPILDEAEFLEL 666
|
|
| ligA |
PRK07956 |
NAD-dependent DNA ligase LigA; Validated |
3-790 |
0e+00 |
|
NAD-dependent DNA ligase LigA; Validated
Pssm-ID: 236137 [Multi-domain] Cd Length: 665 Bit Score: 1115.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 3 DTQAAAERIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPTQRVSGTPASAFGEVRHEIPM 82
Cdd:PRK07956 1 TMEEAKKRIEELREELNHHAYAYYVLDAPSISDAEYDRLYRELVALEAEHPELITPDSPTQRVGGAPLDGFEKVRHLVPM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 83 LSLGNAFEEQDLLDFDRRVREGLADllpggdllgggAEVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITSNV 162
Cdd:PRK07956 81 LSLDNAFSEEELRAFDKRVRKRLPD-----------PPLTYLCELKIDGLAVSLLYENGVLVRAATRGDGTTGEDITANV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 163 RTIRNVPLKLHgEGWPEILEVRGEVFMSKAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGFGQ 242
Cdd:PRK07956 150 RTIRSIPLRLH-GNEPERLEVRGEVFMPKADFEALNEERREEGEKPFANPRNAAAGSLRQLDPKITAKRPLSFFAYGVGE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 243 VS-GTLPDTQVGILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPRW 321
Cdd:PRK07956 229 VEgGELPDSQSEALEFLKAWGFPVNPYRKLCTSIEEVLAFYEEIEEERHDLPYDIDGVVIKVDDLALQEELGFTAKAPRW 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 322 AIAHKFPAREELTELLGVEFQVGRTGAVTPVARLKPVQVAGVTVSNATLHNMDEVARLGLRIGDTVVIRRAGDVIPQVMQ 401
Cdd:PRK07956 309 AIAYKFPAEEATTKLLDIEVQVGRTGAVTPVARLEPVEVAGVTVSRATLHNADEIERKDIRIGDTVVVRRAGDVIPEVVG 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 402 VVLERRPADAQAIEVPEHCPVCGSAVERtqlvkrskgkesISEGAIYRCVGRLSCQAQLKQAIIHFVSRRAMDIDGLGDK 481
Cdd:PRK07956 389 VVLEKRPGDEREIVMPTHCPVCGSELVR------------VEGEAVLRCTNGLSCPAQLKERLIHFVSRNAMDIDGLGEK 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 482 IVEQLVDRGLVASPADLYTLTYEQVFELEGFAELSTNNLLTAIADSRKPSLARFIFALGIPDVGEETAKLLARSLGSLER 561
Cdd:PRK07956 457 IIEQLFEKGLIHDPADLFKLTAEDLLGLEGFGEKSAQNLLDAIEKSKETSLARFLYALGIRHVGEKAAKALARHFGSLEA 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 562 IGKALPEVLTYLPDVGAEVAYEIHNFFADEHNRQVIAQLRDAehGVQLQEEGEVAaefaacaslagfidklnipfiaatg 641
Cdd:PRK07956 537 LRAASEEELAAVEGVGEVVAQSIVEFFAVEENRELIDELLEA--GVNMEYKGEEV------------------------- 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 642 aeklasrfgsldgiiradwldlrqverlperaakslrdffdepanvqralaieaqlrefgmhwqserkaveglPLAGQTW 721
Cdd:PRK07956 590 -------------------------------------------------------------------------DLAGKTV 596
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596726 722 VLTGTLEAMSRDVAKDKLEGLGAKVAGSVSAKTHCVVAGPGAGSKLAKANELGVKVLDEDGLLKLFDEH 790
Cdd:PRK07956 597 VLTGTLEQLSRDEAKEKLEALGAKVSGSVSKKTDLVVAGEAAGSKLAKAQELGIEVLDEEEFLRLLGEG 665
|
|
| dnlj |
TIGR00575 |
DNA ligase, NAD-dependent; All proteins in this family with known functions are NAD-dependent ... |
14-783 |
0e+00 |
|
DNA ligase, NAD-dependent; All proteins in this family with known functions are NAD-dependent DNA ligases. Functions of these proteins include DNA repair, DNA replication, and DNA recombination. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The member of this family from Treponema pallidum differs in having three rather than just one copy of the BRCT (BRCA1 C Terminus) domain (pfam00533) at the C-terminus. It is included in the seed. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273148 [Multi-domain] Cd Length: 652 Bit Score: 863.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 14 LRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPTQRVSGTPASAFGEVRHEIPMLSLGNAFEEQD 93
Cdd:TIGR00575 1 LRKLIRHHDYRYYVLDEPSISDAEYDRLYRELQELEEKHPELITPDSPTQRVGAAPLSRFPKVRHSTPMLSLDNAFDEDE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 94 LLDFDRRVREGLADLlpggdllgggaeVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITSNVRTIRNVPLKLH 173
Cdd:TIGR00575 81 LAAFIKRIRRQLGLK------------VEYVVEPKIDGLSVSLTYENGVLVRALTRGDGTVGEDVTANVRTIRSIPLRLA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 174 GEGWPEILEVRGEVFMSKAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGFGQVSGTLPDTQVG 253
Cdd:TIGR00575 149 GDNPPERLEVRGEVFMPKEDFEALNEERREQGEKPFANPRNAAAGSLRQLDPRITAKRKLRFFAYGLGEGLELPDATQYE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 254 ILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPRWAIAHKFPAREEL 333
Cdd:TIGR00575 229 ALAWLKKWGFPVSPHIRLCDSIEEVLEYYREIEEKRDSLPYEIDGVVVKVDDLALQDELGFTSKAPRWAIAYKFPAEEAQ 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 334 TELLGVEFQVGRTGAVTPVARLKPVQVAGVTVSNATLHNMDEVARLGLRIGDTVVIRRAGDVIPQVMQVVLERRPADAQA 413
Cdd:TIGR00575 309 TKLLDVVVQVGRTGAITPVAKLEPVFVAGTTVSRATLHNEDEIEELDIRIGDTVVVRKAGDVIPKVVRVLLEKRTGSERP 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 414 IEVPEHCPVCGSAVERtqlvkrskgkesISEGAIYRCVGrLSCQAQLKQAIIHFVSRRAMDIDGLGDKIVEQLVDRGLVA 493
Cdd:TIGR00575 389 IRFPTHCPSCGSPLVK------------IEEEAVIRCPN-LNCPAQRVERIKHFASRNAMDIEGLGDKVIEQLFEKKLVR 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 494 SPADLYTLTYEQVFELEGFAELSTNNLLTAIADSRKPSLARFIFALGIPDVGEETAKLLARSLGSLERIGKALPEVLTYL 573
Cdd:TIGR00575 456 SVADLYALKKEDLLELEGFGEKSAQNLLNAIEKSKEKPLARLLFALGIRHVGEVTAKNLAKHFGTLDKLKAASLEELLSV 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 574 PDVGAEVAYEIHNFFADEHNRQVIAQLRDAehGVQLQEEGEVAAefaacaslagfidklnipfiaatgaeklasrfgsld 653
Cdd:TIGR00575 536 EGVGPKVAESIVNFFHDPNNRQLIKKLEEL--GVEMESLPEKVN------------------------------------ 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 654 giiradwldlrqverlperaakslrdfFDEpanvqralaieaqlrefgmhwqserkavEGLPLAGQTWVLTGTLEAMSRD 733
Cdd:TIGR00575 578 ---------------------------AEL----------------------------AGSPLAGKTFVLTGTLSQMSRD 602
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|
gi 15596726 734 VAKDKLEGLGAKVAGSVSAKTHCVVAGPGAGSKLAKANELGVKVLDEDGL 783
Cdd:TIGR00575 603 EAKELLENLGGKVASSVSKKTDYVIAGEKAGSKLAKAQELGIPIINEEEL 652
|
|
| LIGANc |
smart00532 |
Ligase N family; |
7-472 |
0e+00 |
|
Ligase N family;
Pssm-ID: 214709 [Multi-domain] Cd Length: 441 Bit Score: 648.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 7 AAERIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPTQRVSGTPASAFGEVRHEIPMLSLG 86
Cdd:smart00532 1 AQKEISELRKLLNQHDYRYYVLDAPIISDAEYDRLMRELKELEEKHPELKTPDSPTQRVGGKPLEGFNKVRHPVPMLSLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 87 NAFEEQDLLDFDRRVREGLADllpggdllgggaEVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITSNVRTIR 166
Cdd:smart00532 81 NAFDEDELRAFDERIEKALGS------------PFAYVVEPKIDGLSVSLLYENGKLVQAATRGDGTVGEDVTQNVKTIR 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 167 NVPLKLHGEgWPEILEVRGEVFMSKAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGFGQVSG- 245
Cdd:smart00532 149 SIPLRLSGD-VPERLEVRGEVFMPKEDFLALNEELEEEGEKPFANPRNAAAGSLRQLDPRITAKRKLRAFFYGLGTGEEl 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 246 TLPDTQVGILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPRWAIAH 325
Cdd:smart00532 228 FLPKTQSEALKWLKELGFPVSPHTRLCKNADEVIEYYEEWEEKRAELPYEIDGVVVKVDDLALQRELGFTSKAPRWAIAY 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 326 KFPAREELTELLGVEFQVGRTGAVTPVARLKPVQVAGVTVSNATLHNMDEVARLGLRIGDTVVIRRAGDVIPQVMQVVLE 405
Cdd:smart00532 308 KFPAEEAETKLLDIIVQVGRTGKITPVAELEPVFLAGSTVSRATLHNEDEIEEKDIRIGDTVVVRKAGDVIPKVVGVVKE 387
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596726 406 RRPADAQAIEVPEHCPVCGSAVERtqlvkrskgkesISEGAIYRCVGrLSCQAQLKQAIIHFVSRRA 472
Cdd:smart00532 388 KRPGDEREIEMPTHCPSCGSELVR------------EEGEVDIRCPN-PLCPAQLIERIIHFASRKA 441
|
|
| LIGANc |
cd00114 |
NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining ... |
9-329 |
1.84e-179 |
|
NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction mechanism. The enzyme reacts with the cofactor to form a phosphoamide-linked AMP with the amino group of a conserved Lysine in the KXDG motif, and subsequently transfers it to the DNA substrate to yield adenylated DNA. This alignment contains members of the NAD+ dependent subfamily only.
Pssm-ID: 238062 [Multi-domain] Cd Length: 307 Bit Score: 516.37 E-value: 1.84e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 9 ERIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPTQRVSGTPASAFGEVRHEIPMLSLGNA 88
Cdd:cd00114 1 ERIAELRELLNKHDYRYYVLDEPSVSDAEYDRLYRELRALEEEHPELKTPDSPTQRVGGTPLSGFKKVRHPVPMLSLDNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 89 FEEQDLLDFDRRVREGLAdllpggdllgggAEVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITSNVRTIRNV 168
Cdd:cd00114 81 FDEEELRAFDERIKRFLG------------EEPAYVVEPKIDGLSISLRYENGVLVQAATRGDGTTGEDVTENVRTIRSI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 169 PLKLHGegWPEILEVRGEVFMSKAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGFGQVSGTLP 248
Cdd:cd00114 149 PLTLAG--APETLEVRGEVFMPKADFEALNKEREERGEKPFANPRNAAAGSLRQLDPKITAKRPLRFFIYGLGEAEGLGP 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 249 DTQVGILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPRWAIAHKFP 328
Cdd:cd00114 227 KTQSEALAFLKEWGFPVSPETRLCKNIEEVLAFYDEIEAKRDSLPYEIDGVVVKVDDLALQRELGFTSKAPRWAIAYKFP 306
|
.
gi 15596726 329 A 329
Cdd:cd00114 307 A 307
|
|
| DNA_ligase_aden |
pfam01653 |
NAD-dependent DNA ligase adenylation domain; DNA ligases catalyze the crucial step of joining ... |
6-330 |
7.33e-163 |
|
NAD-dependent DNA ligase adenylation domain; DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor. This domain is the catalytic adenylation domain. The NAD+ group is covalently attached to this domain at the lysine in the KXDG motif of this domain. This enzyme- adenylate intermediate is an important feature of the proposed catalytic mechanism.
Pssm-ID: 396292 [Multi-domain] Cd Length: 318 Bit Score: 474.53 E-value: 7.33e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 6 AAAERIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPTQRVSGTPASAFGEVRHEIPMLSL 85
Cdd:pfam01653 2 EAQQQLEELRELIRKYDYEYYVLDNPSVPDAEYDRLYRELKALEEKHPELITPDSPTQRVGAVPLADFNKVRHLTPMLSL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 86 GNAFEEQDLLDFDRRVREGLadllpggdllGGGAEVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITSNVRTI 165
Cdd:pfam01653 82 DNAFNLDELQAFIERIRRAL----------GNKEKVEYVVEPKIDGLSISLLYENGLLVRAATRGDGTTGEDVTANVKTI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 166 RNVPLKLHGEGWPEILEVRGEVFMSKAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGFGQVSG 245
Cdd:pfam01653 152 RNIPLKLKGDNPPERLEVRGEVFMPKEDFEALNEERLEEGEKPFANPRNAAAGSLRQLDPRITAKRKLRFFAYGLGLLEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 246 TL--PDTQVGILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPRWAI 323
Cdd:pfam01653 232 HElgFDTQYQALAFLKSLGFPVSPLLALCDGIEEVLAYYADWEKKRDSLPYEIDGVVVKVDELALQRELGFTAKAPRWAI 311
|
....*..
gi 15596726 324 AHKFPAR 330
Cdd:pfam01653 312 AYKFPAE 318
|
|
| HHH_2 |
pfam12826 |
Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is ... |
628-686 |
4.72e-09 |
|
Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.
Pssm-ID: 432812 [Multi-domain] Cd Length: 64 Bit Score: 53.30 E-value: 4.72e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 15596726 628 FIDKLNIPFIAATGAEKLASRFGSLDGIIRADWLDLRQVERLPERAAKSLRDFFDEPAN 686
Cdd:pfam12826 2 LLFALGIRHVGETTAKLLARRFGSLDALAEASLEELLEVDDIGPEIAQSIVEFFADPAN 60
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Lig |
COG0272 |
NAD-dependent DNA ligase [Replication, recombination and repair]; |
1-786 |
0e+00 |
|
NAD-dependent DNA ligase [Replication, recombination and repair];
Pssm-ID: 440042 [Multi-domain] Cd Length: 668 Bit Score: 1128.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 1 MTDTQAAaERIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPTQRVSGTPASAFGEVRHEI 80
Cdd:COG0272 1 MTPEEAK-ERIEELREELRRHNYRYYVLDAPEISDAEYDALLRELQALEAEHPELITPDSPTQRVGGAPLEGFAKVRHAV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 81 PMLSLGNAFEEQDLLDFDRRVREGLadllpggdllgGGAEVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITS 160
Cdd:COG0272 80 PMLSLDNAFSEEELRDFDRRVRKFL-----------GDEPVEYVCELKIDGLAISLRYENGRLVRAATRGDGTVGEDVTA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 161 NVRTIRNVPLKLHGEGWPEILEVRGEVFMSKAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGF 240
Cdd:COG0272 149 NVRTIRSIPLRLKGDDVPEVLEVRGEVYMPKADFEALNEEREEAGEKPFANPRNAAAGSLRQLDPKITAKRPLDFFAYGL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 241 GQVSGTLPDTQVGILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPR 320
Cdd:COG0272 229 GEVEGLLPDTQSEALELLKEWGFPVNPERRVCKSIEEVLAYIEEWEEKRHSLPYEIDGVVIKVNDLALQERLGFTSRAPR 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 321 WAIAHKFPAREELTELLGVEFQVGRTGAVTPVARLKPVQVAGVTVSNATLHNMDEVARLGLRIGDTVVIRRAGDVIPQVM 400
Cdd:COG0272 309 WAIAYKFPAEEATTKLLDIEVQVGRTGALTPVARLEPVFVAGVTVSRATLHNEDEIERKDVRIGDTVVVRKAGDVIPEVV 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 401 QVVLERRPADAQAIEVPEHCPVCGSAVERtqlvkrskgkesISEGAIYRCVGRLSCQAQLKQAIIHFVSRRAMDIDGLGD 480
Cdd:COG0272 389 GVVLEKRPGDEKPFVMPTHCPVCGSPLVR------------EEGEAALRCTNGLSCPAQLKERLKHFASRKAMDIEGLGE 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 481 KIVEQLVDRGLVASPADLYTLTYEQVFELEGFAELSTNNLLTAIADSRKPSLARFIFALGIPDVGEETAKLLARSLGSLE 560
Cdd:COG0272 457 KLIEQLVDAGLVKDPADLYRLTKEDLLGLERMGEKSAQNLLAAIEKSKKTPLARFLFALGIRHVGETTAKLLARHFGSLD 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 561 RIGKALPEVLTYLPDVGAEVAYEIHNFFADEHNRQVIAQLRDAehGVQLQEEgevaaefaacaslagfidklnipfiaat 640
Cdd:COG0272 537 ALMAASEEELAAVDGIGPVVAESIVEFFAEPHNRELIERLRAA--GVNMEEE---------------------------- 586
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 641 gaeklasrfgsldgiiradwldlrqverlperaakslrdffdepanvqralaieaqlrefgmhwqsERKAVEGLPLAGQT 720
Cdd:COG0272 587 ------------------------------------------------------------------EAEAAADSPLAGKT 600
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596726 721 WVLTGTLEAMSRDVAKDKLEGLGAKVAGSVSAKTHCVVAGPGAGSKLAKANELGVKVLDEDGLLKL 786
Cdd:COG0272 601 FVLTGTLETMTRDEAKELIEALGGKVSGSVSKKTDYVVAGENAGSKLDKAEELGVPILDEAEFLEL 666
|
|
| ligA |
PRK07956 |
NAD-dependent DNA ligase LigA; Validated |
3-790 |
0e+00 |
|
NAD-dependent DNA ligase LigA; Validated
Pssm-ID: 236137 [Multi-domain] Cd Length: 665 Bit Score: 1115.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 3 DTQAAAERIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPTQRVSGTPASAFGEVRHEIPM 82
Cdd:PRK07956 1 TMEEAKKRIEELREELNHHAYAYYVLDAPSISDAEYDRLYRELVALEAEHPELITPDSPTQRVGGAPLDGFEKVRHLVPM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 83 LSLGNAFEEQDLLDFDRRVREGLADllpggdllgggAEVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITSNV 162
Cdd:PRK07956 81 LSLDNAFSEEELRAFDKRVRKRLPD-----------PPLTYLCELKIDGLAVSLLYENGVLVRAATRGDGTTGEDITANV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 163 RTIRNVPLKLHgEGWPEILEVRGEVFMSKAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGFGQ 242
Cdd:PRK07956 150 RTIRSIPLRLH-GNEPERLEVRGEVFMPKADFEALNEERREEGEKPFANPRNAAAGSLRQLDPKITAKRPLSFFAYGVGE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 243 VS-GTLPDTQVGILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPRW 321
Cdd:PRK07956 229 VEgGELPDSQSEALEFLKAWGFPVNPYRKLCTSIEEVLAFYEEIEEERHDLPYDIDGVVIKVDDLALQEELGFTAKAPRW 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 322 AIAHKFPAREELTELLGVEFQVGRTGAVTPVARLKPVQVAGVTVSNATLHNMDEVARLGLRIGDTVVIRRAGDVIPQVMQ 401
Cdd:PRK07956 309 AIAYKFPAEEATTKLLDIEVQVGRTGAVTPVARLEPVEVAGVTVSRATLHNADEIERKDIRIGDTVVVRRAGDVIPEVVG 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 402 VVLERRPADAQAIEVPEHCPVCGSAVERtqlvkrskgkesISEGAIYRCVGRLSCQAQLKQAIIHFVSRRAMDIDGLGDK 481
Cdd:PRK07956 389 VVLEKRPGDEREIVMPTHCPVCGSELVR------------VEGEAVLRCTNGLSCPAQLKERLIHFVSRNAMDIDGLGEK 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 482 IVEQLVDRGLVASPADLYTLTYEQVFELEGFAELSTNNLLTAIADSRKPSLARFIFALGIPDVGEETAKLLARSLGSLER 561
Cdd:PRK07956 457 IIEQLFEKGLIHDPADLFKLTAEDLLGLEGFGEKSAQNLLDAIEKSKETSLARFLYALGIRHVGEKAAKALARHFGSLEA 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 562 IGKALPEVLTYLPDVGAEVAYEIHNFFADEHNRQVIAQLRDAehGVQLQEEGEVAaefaacaslagfidklnipfiaatg 641
Cdd:PRK07956 537 LRAASEEELAAVEGVGEVVAQSIVEFFAVEENRELIDELLEA--GVNMEYKGEEV------------------------- 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 642 aeklasrfgsldgiiradwldlrqverlperaakslrdffdepanvqralaieaqlrefgmhwqserkaveglPLAGQTW 721
Cdd:PRK07956 590 -------------------------------------------------------------------------DLAGKTV 596
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596726 722 VLTGTLEAMSRDVAKDKLEGLGAKVAGSVSAKTHCVVAGPGAGSKLAKANELGVKVLDEDGLLKLFDEH 790
Cdd:PRK07956 597 VLTGTLEQLSRDEAKEKLEALGAKVSGSVSKKTDLVVAGEAAGSKLAKAQELGIEVLDEEEFLRLLGEG 665
|
|
| dnlj |
TIGR00575 |
DNA ligase, NAD-dependent; All proteins in this family with known functions are NAD-dependent ... |
14-783 |
0e+00 |
|
DNA ligase, NAD-dependent; All proteins in this family with known functions are NAD-dependent DNA ligases. Functions of these proteins include DNA repair, DNA replication, and DNA recombination. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The member of this family from Treponema pallidum differs in having three rather than just one copy of the BRCT (BRCA1 C Terminus) domain (pfam00533) at the C-terminus. It is included in the seed. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273148 [Multi-domain] Cd Length: 652 Bit Score: 863.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 14 LRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPTQRVSGTPASAFGEVRHEIPMLSLGNAFEEQD 93
Cdd:TIGR00575 1 LRKLIRHHDYRYYVLDEPSISDAEYDRLYRELQELEEKHPELITPDSPTQRVGAAPLSRFPKVRHSTPMLSLDNAFDEDE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 94 LLDFDRRVREGLADLlpggdllgggaeVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITSNVRTIRNVPLKLH 173
Cdd:TIGR00575 81 LAAFIKRIRRQLGLK------------VEYVVEPKIDGLSVSLTYENGVLVRALTRGDGTVGEDVTANVRTIRSIPLRLA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 174 GEGWPEILEVRGEVFMSKAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGFGQVSGTLPDTQVG 253
Cdd:TIGR00575 149 GDNPPERLEVRGEVFMPKEDFEALNEERREQGEKPFANPRNAAAGSLRQLDPRITAKRKLRFFAYGLGEGLELPDATQYE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 254 ILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPRWAIAHKFPAREEL 333
Cdd:TIGR00575 229 ALAWLKKWGFPVSPHIRLCDSIEEVLEYYREIEEKRDSLPYEIDGVVVKVDDLALQDELGFTSKAPRWAIAYKFPAEEAQ 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 334 TELLGVEFQVGRTGAVTPVARLKPVQVAGVTVSNATLHNMDEVARLGLRIGDTVVIRRAGDVIPQVMQVVLERRPADAQA 413
Cdd:TIGR00575 309 TKLLDVVVQVGRTGAITPVAKLEPVFVAGTTVSRATLHNEDEIEELDIRIGDTVVVRKAGDVIPKVVRVLLEKRTGSERP 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 414 IEVPEHCPVCGSAVERtqlvkrskgkesISEGAIYRCVGrLSCQAQLKQAIIHFVSRRAMDIDGLGDKIVEQLVDRGLVA 493
Cdd:TIGR00575 389 IRFPTHCPSCGSPLVK------------IEEEAVIRCPN-LNCPAQRVERIKHFASRNAMDIEGLGDKVIEQLFEKKLVR 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 494 SPADLYTLTYEQVFELEGFAELSTNNLLTAIADSRKPSLARFIFALGIPDVGEETAKLLARSLGSLERIGKALPEVLTYL 573
Cdd:TIGR00575 456 SVADLYALKKEDLLELEGFGEKSAQNLLNAIEKSKEKPLARLLFALGIRHVGEVTAKNLAKHFGTLDKLKAASLEELLSV 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 574 PDVGAEVAYEIHNFFADEHNRQVIAQLRDAehGVQLQEEGEVAAefaacaslagfidklnipfiaatgaeklasrfgsld 653
Cdd:TIGR00575 536 EGVGPKVAESIVNFFHDPNNRQLIKKLEEL--GVEMESLPEKVN------------------------------------ 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 654 giiradwldlrqverlperaakslrdfFDEpanvqralaieaqlrefgmhwqserkavEGLPLAGQTWVLTGTLEAMSRD 733
Cdd:TIGR00575 578 ---------------------------AEL----------------------------AGSPLAGKTFVLTGTLSQMSRD 602
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|
gi 15596726 734 VAKDKLEGLGAKVAGSVSAKTHCVVAGPGAGSKLAKANELGVKVLDEDGL 783
Cdd:TIGR00575 603 EAKELLENLGGKVASSVSKKTDYVIAGEKAGSKLAKAQELGIPIINEEEL 652
|
|
| LIGANc |
smart00532 |
Ligase N family; |
7-472 |
0e+00 |
|
Ligase N family;
Pssm-ID: 214709 [Multi-domain] Cd Length: 441 Bit Score: 648.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 7 AAERIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPTQRVSGTPASAFGEVRHEIPMLSLG 86
Cdd:smart00532 1 AQKEISELRKLLNQHDYRYYVLDAPIISDAEYDRLMRELKELEEKHPELKTPDSPTQRVGGKPLEGFNKVRHPVPMLSLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 87 NAFEEQDLLDFDRRVREGLADllpggdllgggaEVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITSNVRTIR 166
Cdd:smart00532 81 NAFDEDELRAFDERIEKALGS------------PFAYVVEPKIDGLSVSLLYENGKLVQAATRGDGTVGEDVTQNVKTIR 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 167 NVPLKLHGEgWPEILEVRGEVFMSKAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGFGQVSG- 245
Cdd:smart00532 149 SIPLRLSGD-VPERLEVRGEVFMPKEDFLALNEELEEEGEKPFANPRNAAAGSLRQLDPRITAKRKLRAFFYGLGTGEEl 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 246 TLPDTQVGILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPRWAIAH 325
Cdd:smart00532 228 FLPKTQSEALKWLKELGFPVSPHTRLCKNADEVIEYYEEWEEKRAELPYEIDGVVVKVDDLALQRELGFTSKAPRWAIAY 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 326 KFPAREELTELLGVEFQVGRTGAVTPVARLKPVQVAGVTVSNATLHNMDEVARLGLRIGDTVVIRRAGDVIPQVMQVVLE 405
Cdd:smart00532 308 KFPAEEAETKLLDIIVQVGRTGKITPVAELEPVFLAGSTVSRATLHNEDEIEEKDIRIGDTVVVRKAGDVIPKVVGVVKE 387
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596726 406 RRPADAQAIEVPEHCPVCGSAVERtqlvkrskgkesISEGAIYRCVGrLSCQAQLKQAIIHFVSRRA 472
Cdd:smart00532 388 KRPGDEREIEMPTHCPSCGSELVR------------EEGEVDIRCPN-PLCPAQLIERIIHFASRKA 441
|
|
| ligA |
PRK14351 |
NAD-dependent DNA ligase LigA; Provisional |
3-793 |
0e+00 |
|
NAD-dependent DNA ligase LigA; Provisional
Pssm-ID: 184640 [Multi-domain] Cd Length: 689 Bit Score: 634.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 3 DTQAAAERIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYpQLLTPDSPTQRVSGTPASAFGEVRHEIPM 82
Cdd:PRK14351 28 SEDEAEEQAEQLREAIREHDHRYYVEADPVIADRAYDALFARLQALEDAF-DLDTENSPTRRVGGEPLDELETVEHVAPM 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 83 LSLGNAFEEQDLLDFDRRVREGLAdllpggdllgggaEVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITSNV 162
Cdd:PRK14351 107 LSIDQSGEADDVREFDERVRREVG-------------AVEYVCEPKFDGLSVEVVYEDGEYQRAATRGDGREGDDVTANV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 163 RTIRNVPLKLHGEgWPEILEVRGEVFMSKAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGFGQ 242
Cdd:PRK14351 174 RTIRSVPQKLRGD-YPDFLAVRGEVYMPKDAFQAYNRERIERGEEPFANPRNAAAGTLRQLDPSVVAERPLDIFFFDVLD 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 243 VSgTLPDTQVGILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPRWA 322
Cdd:PRK14351 253 AS-ELFDSHWEELERFPEWGLRVTDRTERVDDIDDAIAYRDRLLAARDDLNYEIDGVVIKVDDRDAREELGATARAPRWA 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 323 IAHKFPAREELTELLGVEFQVGRTGAVTPVARLKPVQVAGVTVSNATLHNMDEVARLGLRIGDTVVIRRAGDVIPQVMQV 402
Cdd:PRK14351 332 FAYKFPARAEETTIRDIVVQVGRTGRLTPVALLDPVDVGGVTVSRASLHNPAEIEELGVNVGDRVRVKRAGDVIPYVEEV 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 403 VLERRPAdaqAIEVPEHCPVCGSAVERtqlvkrskgkesisEGAIYRCVGRLSCQAQLKQAIIHFVSRRAMDIDGLGDKI 482
Cdd:PRK14351 412 VEKDSEG---TFEFPDTCPVCDSAVER--------------DGPLAFCTGGLACPAQLERSIEHYASRDALDIEGLGEER 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 483 VEQLVDRGLVASPADLYTLTYEQVFELEGFAELSTNNLLTAIADSRKPSLARFIFALGIPDVGEETAKLLARSLGSLERI 562
Cdd:PRK14351 475 VQQLVDAGLVESLADLYDLTVADLAELEGWGETSAENLLAELEASREPPLADFLVALGIPEVGPTTARNLAREFGTFEAI 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 563 GKALPEVLTYLPDVGAEVAYEIHNFFADEHNRQVIAQLRDaeHGVQlqeegevaaefaacaslagfidklnipfiaatga 642
Cdd:PRK14351 555 MDADEEALRAVDDVGPTVAEEIREFFDSERNRAVIDDLLD--HGVD---------------------------------- 598
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 643 eklasrfgsldgiiradwldlrqverlPERAakslrdffdepanvqralaieaqlrefgmhwQSErkavEGLPLAGQTWV 722
Cdd:PRK14351 599 ---------------------------PQPA-------------------------------ESE----GGDALDGLTFV 616
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15596726 723 LTGTLEAMSRDVAKDKLEGLGAKVAGSVSAKTHCVVAG--PGAgSKLAKANELGVKVLDEDGLLKLFDEHGVA 793
Cdd:PRK14351 617 FTGSLSGYTRSEAQELVEAHGGNATGSVSGNTDYLVVGenPGQ-SKRDDAEANDVPTLDEEEFEELLAERGVA 688
|
|
| LIGANc |
cd00114 |
NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining ... |
9-329 |
1.84e-179 |
|
NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction mechanism. The enzyme reacts with the cofactor to form a phosphoamide-linked AMP with the amino group of a conserved Lysine in the KXDG motif, and subsequently transfers it to the DNA substrate to yield adenylated DNA. This alignment contains members of the NAD+ dependent subfamily only.
Pssm-ID: 238062 [Multi-domain] Cd Length: 307 Bit Score: 516.37 E-value: 1.84e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 9 ERIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPTQRVSGTPASAFGEVRHEIPMLSLGNA 88
Cdd:cd00114 1 ERIAELRELLNKHDYRYYVLDEPSVSDAEYDRLYRELRALEEEHPELKTPDSPTQRVGGTPLSGFKKVRHPVPMLSLDNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 89 FEEQDLLDFDRRVREGLAdllpggdllgggAEVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITSNVRTIRNV 168
Cdd:cd00114 81 FDEEELRAFDERIKRFLG------------EEPAYVVEPKIDGLSISLRYENGVLVQAATRGDGTTGEDVTENVRTIRSI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 169 PLKLHGegWPEILEVRGEVFMSKAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGFGQVSGTLP 248
Cdd:cd00114 149 PLTLAG--APETLEVRGEVFMPKADFEALNKEREERGEKPFANPRNAAAGSLRQLDPKITAKRPLRFFIYGLGEAEGLGP 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 249 DTQVGILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPRWAIAHKFP 328
Cdd:cd00114 227 KTQSEALAFLKEWGFPVSPETRLCKNIEEVLAFYDEIEAKRDSLPYEIDGVVVKVDDLALQRELGFTSKAPRWAIAYKFP 306
|
.
gi 15596726 329 A 329
Cdd:cd00114 307 A 307
|
|
| DNA_ligase_aden |
pfam01653 |
NAD-dependent DNA ligase adenylation domain; DNA ligases catalyze the crucial step of joining ... |
6-330 |
7.33e-163 |
|
NAD-dependent DNA ligase adenylation domain; DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor. This domain is the catalytic adenylation domain. The NAD+ group is covalently attached to this domain at the lysine in the KXDG motif of this domain. This enzyme- adenylate intermediate is an important feature of the proposed catalytic mechanism.
Pssm-ID: 396292 [Multi-domain] Cd Length: 318 Bit Score: 474.53 E-value: 7.33e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 6 AAAERIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPTQRVSGTPASAFGEVRHEIPMLSL 85
Cdd:pfam01653 2 EAQQQLEELRELIRKYDYEYYVLDNPSVPDAEYDRLYRELKALEEKHPELITPDSPTQRVGAVPLADFNKVRHLTPMLSL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 86 GNAFEEQDLLDFDRRVREGLadllpggdllGGGAEVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITSNVRTI 165
Cdd:pfam01653 82 DNAFNLDELQAFIERIRRAL----------GNKEKVEYVVEPKIDGLSISLLYENGLLVRAATRGDGTTGEDVTANVKTI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 166 RNVPLKLHGEGWPEILEVRGEVFMSKAGFEALNAKAVETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGFGQVSG 245
Cdd:pfam01653 152 RNIPLKLKGDNPPERLEVRGEVFMPKEDFEALNEERLEEGEKPFANPRNAAAGSLRQLDPRITAKRKLRFFAYGLGLLEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 246 TL--PDTQVGILEAFRGWGIPISRELRLVKGAQACRDYYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPRWAI 323
Cdd:pfam01653 232 HElgFDTQYQALAFLKSLGFPVSPLLALCDGIEEVLAYYADWEKKRDSLPYEIDGVVVKVDELALQRELGFTAKAPRWAI 311
|
....*..
gi 15596726 324 AHKFPAR 330
Cdd:pfam01653 312 AYKFPAE 318
|
|
| ligA |
PRK14350 |
NAD-dependent DNA ligase LigA; Provisional |
9-778 |
8.04e-107 |
|
NAD-dependent DNA ligase LigA; Provisional
Pssm-ID: 172826 [Multi-domain] Cd Length: 669 Bit Score: 341.81 E-value: 8.04e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 9 ERIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPTQRVSGTPASAFGEVRHEIPMLSLGNA 88
Cdd:PRK14350 7 DEILDLKKLIRKWDKEYYVDSSPSVEDFTYDKALLRLQELESKYPEYKTLDSPTLKFGSDLLNDFKEVEHSFPILSLDKV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 89 FEEQDLLDF-DRRVREGladllpggdlLGGGAEVEYSCEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITSNVRTIRN 167
Cdd:PRK14350 87 YDLKLLKLWiEKMDLEN----------SNLGFDFGISVEPKIDGCSIVLYYKDGILEKALTRGDGRFGNDVTENVRTIRN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 168 VPLKLhGEGWPEILevRGEVFMSKAGFEALNakavETGGKTFANPRNAAAGSLRQLDSKITASRPLEFCAYGFGQVSGTL 247
Cdd:PRK14350 157 VPLFI-DEKVELVL--RGEIYITKENFLKIN----KTLEKPYTNARNLASGILRRIDSREVANFPLDIFVYDILYSSLEL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 248 PDTQVGIlEAFRGWGIPISRELRLVKGAQACRD---YYDDIGRRRDALAYEIDGVVFKVNRIAFQRELGFRAREPRWAIA 324
Cdd:PRK14350 230 KTNHDAF-DKLKKFGFKVNPFCRFFDGKNSIEEilnYVKDIEKKRNSFEYEIDGVVLKVSDFALREILGYTSHHPKWSMA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 325 HKFPAREELTELLGVEFQVGRTGAVTPVARLKPVQVAGVTVSNATLHNMDEVARLGLRIGDTVVIRRAGDVIPQVmQVVL 404
Cdd:PRK14350 309 YKFESLSGFSKVNDIVVQVGRSGKITPVANIEKVFVAGAFITNASLHNQDYIDSIGLNVGDVVKISRRGDVIPAV-ELVI 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 405 ERrpADAQAIEVPEHCPVCGSAVertqlvkrskgkesISEGAIYRCVGRlSCQAQLKQAIIHFVSRRAMDIDGLGDKIVE 484
Cdd:PRK14350 388 EK--LSVGFFKIPDNCPSCKTAL--------------IKEGAHLFCVNN-HCPSVIVERIKYFCSKKCMNIVGLSDKTIE 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 485 QLVDRGLVASPADLYTLTYEQVFELEGFAELSTNNLLTAIADSRKPSLARFIFALGIPDVGEETAKLL-ARSLGSLERIG 563
Cdd:PRK14350 451 FLFEKKFISSEIDLYTFNFDRLINLKGFKDKRINNLKRSIEASKKRPFSKLLLSMGIKDLGENTILLLiNNNLNSFDKIS 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 564 KalpevltylpdvgaevayeihnffadehnrqvIAQLRDaehgvqlqeegevaAEFAACASLAGFIDKLNIPFIAATGAE 643
Cdd:PRK14350 531 T--------------------------------LCQDRE--------------FALSKLLKIKGIGEKIALNIIEAFNDK 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 644 KLASRFgsldgiiradwldlrqverlperaakslrDFFDEpanvqralaieaqlREFGMHWQSERKAVEGLPLAGQTWVL 723
Cdd:PRK14350 565 IILDKF-----------------------------NFFKN--------------LGFKMEEDSINIDVENSFLFGKKFCI 601
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*
gi 15596726 724 TGTLEAMSRDVAKDKLEGLGAKVAGSVSAKTHCVVAGPGAGSKLAKANELGVKVL 778
Cdd:PRK14350 602 TGSFNGYSRSVLIDKLTKKGAIFNTCVTKYLDFLLVGEKAGLKLKKANNLGIKIM 656
|
|
| COG5275 |
COG5275 |
BRCT domain type II [General function prediction only]; |
530-791 |
1.35e-49 |
|
BRCT domain type II [General function prediction only];
Pssm-ID: 444086 [Multi-domain] Cd Length: 288 Bit Score: 176.38 E-value: 1.35e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 530 PSLARFIFALGIPDVGEETAKLLARSLGSLERIGKALPEVLTYLPDVGAEVAYEIHNFFADEHNRQVIAQLRDaeHGVQL 609
Cdd:COG5275 1 DTLHEKIMARFVDRRTSALMRGLAVREEMLAGVAADGPQTVEGHPVIRLSGAQFEAAQGQSVLETKELRAALD--HAVGV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 610 QEEGEVAAEFAACASLAGFIDKLNIPFIAATGAEKLASRFGSLDGIIRADWLDLRQVERLPERAAKslRDFFDEPANVQR 689
Cdd:COG5275 79 EIAKELGRLAAAPDEAFGLSPDGTVLWQGEAAGVKTGGAPFSLRKRLLADLGHDAARQRAQRALEA--FEAFEAARRLSL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 690 ALAIEAQLREFGMHWQSERKAVEGLP---------------------------LAGQTWVLTGTLEAMSRDVAKDKLEGL 742
Cdd:COG5275 157 LRALEVAVAEGKIRGSAEGLAYRLPEsrkragrvldraevrqdvelyqvekraLRGLRVVITGALSLMMRDLLQDLARAL 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 15596726 743 GAKVAGSVSAKTHCVVAGPG--AGSKLAKANELGVKVLDEDGLLKLFDEHG 791
Cdd:COG5275 237 GAHVAQSIASKTTCLVTGPQdsASSKALKAYQLGVPVVDEEAFDELLAEEG 287
|
|
| ligB |
PRK08097 |
NAD-dependent DNA ligase LigB; |
1-607 |
2.13e-46 |
|
NAD-dependent DNA ligase LigB;
Pssm-ID: 236150 [Multi-domain] Cd Length: 562 Bit Score: 174.72 E-value: 2.13e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 1 MTDTQAAAErIAQLRTELDTHNYRYYVLDEPSIPDAEYDRLFRELQALEAEYPQLLTPDSPtqrvsgtPASAFGEVRHEI 80
Cdd:PRK08097 25 WSPARAQEE-IAALQQQLAQWDDAYWRQGKSEVDDEVYDQLRARLTQWQRCFGGPEPRDVP-------LPPLNGKVLHPV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 81 PMLSLGNAFEEQDLLDFDRRvREGLADllpggdllgggaeveyscEPKLDGLAVSLLYERGQLVRGATRGDGSTGEDITS 160
Cdd:PRK08097 97 AHTGVKKLADKQALARWMAG-RSDLWV------------------QPKVDGVAVTLVYRDGKLVQAISRGNGLKGEDWTA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 161 NVRTIRNVPLKLHGEgwPEILEVRGEVFMSKAGFeaLNAKAvetGGktfANPRNAAAGSL-RQLDSKITASRPLEFCAYG 239
Cdd:PRK08097 158 KARLIPAIPQQLPGA--LANLVLQGELFLRREGH--IQQQM---GG---INARAKVAGLMmRKDPSPTLNQIGVFVWAWP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 240 FGqvsgtlPDTQVGILEAFRGWGIPISREL-RLVKGAqacrdyyDDIGRRRD-----ALAYEIDGVVFK-VNRIAFQRel 312
Cdd:PRK08097 228 DG------PASMPERLAQLATAGFPLTQRYtHPVKNA-------EEVARWRErwyraPLPFVTDGVVVRqAKEPPGRY-- 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 313 gFRAREPRWAIAHKFPAREELTELLGVEFQVGRTGAVTPVARLKPVQVAGVTVSNAtlhNMDEVAR---LGLRIGDTVVI 389
Cdd:PRK08097 293 -WQPGQGEWAVAWKYPPVQQVAEVRAVQFAVGRTGKITVVLELEPVMLDDKRVSRV---NIGSVRRwqqWDIAPGDQVLV 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 390 RRAGDVIPQVMQVVLerRPADAQAIEVPE----HCPVCGSAvertqlvkrskgkesiSEGaiyrcvgrlsCQAQLKQAII 465
Cdd:PRK08097 369 SLAGQGIPRLDKVVW--RGAERTKPTPPDadrfHSLSCFRA----------------SPG----------CQEQFLARLV 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 466 HFVSRRAMDIDGLGDKIVEQLVDRGLVASPADLYTLTYEQVFELEGFAELSTNNLLTAIADSRKPSLARFIFALGIPDVG 545
Cdd:PRK08097 421 WLSGKQGLGLDGIGEGTWRALHQTGLFEHLFSWLALTPEQLANTPGIGKARAEQLWHQFNLARQQPFSRWLKALGIPLPQ 500
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596726 546 EETAKLLARSLGSLerIGKALPEVLTyLPDVGAEVAYEIHNFFADEHNRQVIAQLrdAEHGV 607
Cdd:PRK08097 501 AALNALDDRSWQQL--LSRSEQQWQQ-LPGIGEGRARQLIAFLQHPEVKALADWL--AAQGI 557
|
|
| DNA_ligase_OB |
pfam03120 |
NAD-dependent DNA ligase OB-fold domain; DNA ligases catalyze the crucial step of joining the ... |
334-411 |
1.69e-43 |
|
NAD-dependent DNA ligase OB-fold domain; DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor. This family is a small domain found after the adenylation domain pfam01653 in NAD dependent ligases. OB-fold domains generally are involved in nucleic acid binding.
Pssm-ID: 460813 [Multi-domain] Cd Length: 79 Bit Score: 151.36 E-value: 1.69e-43
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596726 334 TELLGVEFQVGRTGAVTPVARLKPVQVAGVTVSNATLHNMDEVARLGLRIGDTVVIRRAGDVIPQVMQVVLERRPADA 411
Cdd:pfam03120 2 TKLLDIEFQVGRTGAITPVAVLEPVELAGTTVSRATLHNEDEIKRKDIRIGDTVIVRKAGDVIPEVVGVVLEKRPGDE 79
|
|
| HHH_2 |
pfam12826 |
Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is ... |
534-597 |
4.18e-24 |
|
Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.
Pssm-ID: 432812 [Multi-domain] Cd Length: 64 Bit Score: 96.05 E-value: 4.18e-24
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596726 534 RFIFALGIPDVGEETAKLLARSLGSLERIGKALPEVLTYLPDVGAEVAYEIHNFFADEHNRQVI 597
Cdd:pfam12826 1 RLLFALGIRHVGETTAKLLARRFGSLDALAEASLEELLEVDDIGPEIAQSIVEFFADPANRELI 64
|
|
| BRCT_DNA_ligase_like |
cd17748 |
BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also ... |
716-786 |
9.58e-24 |
|
BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also called NAD(+)-dependent polydeoxyribonucleotide synthase, catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.
Pssm-ID: 349379 [Multi-domain] Cd Length: 76 Bit Score: 95.24 E-value: 9.58e-24
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596726 716 LAGQTWVLTGTLEAMSRDVAKDKLEGLGAKVAGSVSAKTHCVVAGPGAGSKLA-----KANELGVKVLDEDGLLKL 786
Cdd:cd17748 1 LAGKTFVFTGTLSSMSRDEAEELIEALGGKVQSSVSKKTDYLVVGDNAGSKLKkgeelKAKGLGIKIISEEEFLDL 76
|
|
| BRCT_RFC1 |
cd17752 |
BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed ... |
716-786 |
4.32e-22 |
|
BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed activator 1 140 kDa subunit, or A1 140 kDa subunit, or activator 1 large subunit, or activator 1 subunit 1, or replication factor C 140 kDa subunit, or RF-C 140 kDa subunit, or RFC140, is the large subunit of replication factor C (RFC), which is a heteropentameric protein essential for DNA replication and repair. RFC1 can bind single- or double-stranded DNA. It could play a role in DNA transcription regulation as well as DNA replication and/or repair. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.
Pssm-ID: 349383 [Multi-domain] Cd Length: 79 Bit Score: 90.74 E-value: 4.32e-22
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596726 716 LAGQTWVLTGTLEAMSRDVAKDKLEGLGAKVAGSVSAKTHCVVAGPGAG-SKLAKANELGVKVLDEDGLLKL 786
Cdd:cd17752 6 LEGLTFVITGVLESLEREEAEDLIKRYGGKVTGSVSKKTSYLVVGRDAGpSKLEKAKELGTKIIDEDGLFDL 77
|
|
| BRCT |
pfam00533 |
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ... |
715-787 |
6.41e-10 |
|
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.
Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 56.15 E-value: 6.41e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15596726 715 PLAGQTWVLTGtLEAMSRDVAKDKLEGLGAKVAGSVSAKTHCVVAGPGAgSKLAKANELGVKVLDEDGLLKLF 787
Cdd:pfam00533 5 LFSGKTFVITG-LDGLERDELKELIEKLGGKVTDSLSKKTTHVIVEART-KKYLKAKELGIPIVTEEWLLDCI 75
|
|
| HHH_2 |
pfam12826 |
Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is ... |
628-686 |
4.72e-09 |
|
Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.
Pssm-ID: 432812 [Multi-domain] Cd Length: 64 Bit Score: 53.30 E-value: 4.72e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 15596726 628 FIDKLNIPFIAATGAEKLASRFGSLDGIIRADWLDLRQVERLPERAAKSLRDFFDEPAN 686
Cdd:pfam12826 2 LLFALGIRHVGETTAKLLARRFGSLDALAEASLEELLEVDDIGPEIAQSIVEFFADPAN 60
|
|
| BRCT |
smart00292 |
breast cancer carboxy-terminal domain; |
715-787 |
1.73e-08 |
|
breast cancer carboxy-terminal domain;
Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 51.99 E-value: 1.73e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596726 715 PLAGQTWVLTGTLEAMSRDVAKDKLEGLGAKVAGSVSAK--THCVVAGPGAGS-KLAKANELGVKVLDEDGLLKLF 787
Cdd:smart00292 3 LFKGKTFYITGSFDKEERDELKELIEALGGKVTSSLSSKttTHVIVGSPEGGKlELLKAIALGIPIVKEEWLLDCL 78
|
|
| BRCT_PARP1 |
cd17747 |
BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2. ... |
716-781 |
3.50e-08 |
|
BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2.30), also termed ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1), or NAD(+) ADP-ribosyltransferase 1 (ADPRT 1), or poly[ADP-ribose] synthase 1, is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism.
Pssm-ID: 349378 [Multi-domain] Cd Length: 76 Bit Score: 50.99 E-value: 3.50e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 716 LAGQTWVLTGTLeAMSRDVAKDKLEGLGAKVAGSVSAKTHCVVAGPGA----GSKLAKANELGVKVLDED 781
Cdd:cd17747 1 LTGMKFALIGKL-SKSKDELKKLIEKLGGKVASKVTKKVTLCISTKAEvekmSKKMKEAKEAGVPVVSED 69
|
|
| DNA_ligase_ZBD |
pfam03119 |
NAD-dependent DNA ligase C4 zinc finger domain; DNA ligases catalyze the crucial step of ... |
419-456 |
5.64e-04 |
|
NAD-dependent DNA ligase C4 zinc finger domain; DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor. This family is a small zinc binding motif that is presumably DNA binding. IT is found only in NAD dependent DNA ligases.
Pssm-ID: 460812 [Multi-domain] Cd Length: 26 Bit Score: 37.80 E-value: 5.64e-04
10 20 30
....*....|....*....|....*....|....*...
gi 15596726 419 HCPVCGSAVERTQlvkrskgkesisEGAIYRCVGrLSC 456
Cdd:pfam03119 1 HCPVCGSPLVREE------------GEAALRCTN-LSC 25
|
|
| BRCT |
cd00027 |
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ... |
722-781 |
1.07e-03 |
|
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.
Pssm-ID: 349339 [Multi-domain] Cd Length: 68 Bit Score: 38.11 E-value: 1.07e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596726 722 VLTGtLEAMSRDVAKDKLEGLGAKVAGSVSAK-THCVVAGPGAGSKLAKANELGVKVLDED 781
Cdd:cd00027 4 CFSG-LDDEEREELKKLIEALGGKVSESLSSKvTHLIAKSPSGEKYYLAALAWGIPIVSPE 63
|
|
| PRK06195 |
PRK06195 |
DNA polymerase III subunit epsilon; Validated |
715-789 |
1.43e-03 |
|
DNA polymerase III subunit epsilon; Validated
Pssm-ID: 235735 [Multi-domain] Cd Length: 309 Bit Score: 41.69 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596726 715 PLAGQTWVLTGTLEAMSRDVAKDKLEGLGAKVAGSVSAKTHCVVAG---------PGAGSKLAKANEL-----GVKVLDE 780
Cdd:PRK06195 220 AFKEEVVVFTGGLASMTRDEAMILVRRLGGTVGSSVTKKTTYLVTNtkdiedlnrEEMSNKLKKAIDLkkkgqNIKFLNE 299
|
....*....
gi 15596726 781 DGLLKLFDE 789
Cdd:PRK06195 300 EEFLQKCKE 308
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
534-584 |
8.16e-03 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 39.86 E-value: 8.16e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 15596726 534 RFIFAlGIPDVGEETAKLLARSLGSLERIGKALPEVLTYLPDVGAEVAYEI 584
Cdd:PRK13766 714 EYIVE-SLPDVGPVLARNLLEHFGSVEAVMTASEEELMEVEGIGEKTAKRI 763
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