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Conserved domains on  [gi|15596875|ref|NP_250369|]
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50S ribosomal protein L3 glutamine methyltransferase [Pseudomonas aeruginosa PAO1]

Protein Classification

ribosomal protein L3 N(5)-glutamine methyltransferase( domain architecture ID 11497021)

ribosomal protein L3 N(5)-glutamine methyltransferase specifically methylates the 50S ribosomal protein L3 on Gln-150 using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; does not methylate the translation termination release factors RF1 and RF2; belongs to the class I SAM-dependent methyltransferase superfamily

CATH:  2.20.25.110
EC:  2.1.1.298
Gene Ontology:  GO:0008757|GO:0006479|GO:1904047|GO:0018364
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 6-288 0e+00

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


:

Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 527.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875     6 LLTLRDYIRWAVSRFHAAGLFFGHGTDNAWDEARHLVLGSLHLPWEISDSYLDCRLEDDERAELAEILRRRIEERIPAAY 85
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875    86 LLGEAWFCGIPFSVDERVLVPRSPIAELIEQRFAPWL-PAEPARILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEV 164
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLePEPVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   165 ANVNIERHDLGERVYTVQGDGFAGLPGQRFDLIVSNPPYVDAEDFADMPAEFHHEPELGLACGDDGLDLVRRMLAEAADH 244
Cdd:TIGR03533 161 AEINIERHGLEDRVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDMADLPAEYHHEPELALASGEDGLDLVRRILAEAADH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 15596875   245 LSEKGLLIVEVGNSEVHVQALYPEVDFTWLEFEHGGHGVFMLSA 288
Cdd:TIGR03533 241 LNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
 
Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 6-288 0e+00

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 527.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875     6 LLTLRDYIRWAVSRFHAAGLFFGHGTDNAWDEARHLVLGSLHLPWEISDSYLDCRLEDDERAELAEILRRRIEERIPAAY 85
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875    86 LLGEAWFCGIPFSVDERVLVPRSPIAELIEQRFAPWL-PAEPARILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEV 164
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLePEPVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   165 ANVNIERHDLGERVYTVQGDGFAGLPGQRFDLIVSNPPYVDAEDFADMPAEFHHEPELGLACGDDGLDLVRRMLAEAADH 244
Cdd:TIGR03533 161 AEINIERHGLEDRVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDMADLPAEYHHEPELALASGEDGLDLVRRILAEAADH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 15596875   245 LSEKGLLIVEVGNSEVHVQALYPEVDFTWLEFEHGGHGVFMLSA 288
Cdd:TIGR03533 241 LNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 8-276 1.36e-103

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 304.00  E-value: 1.36e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   8 TLRDYIRWAVSRFHAAGlffghgTDNAWDEARHLVLGSLHLPWEISDSYLDCRLEDDERAELAEILRRRiEERIPAAYLL 87
Cdd:COG2890   2 TIRELLRWAAARLAAAG------VDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARR-AAGEPLAYIL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875  88 GEAWFCGIPFSVDERVLVPRSPIAELIEQRFApWLPA-EPARILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVAN 166
Cdd:COG2890  75 GEAEFYGLEFKVDPGVLIPRPETEELVELALA-LLPAgAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVAR 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 167 VNIERHDLGERVYTVQGDGFAGLPG-QRFDLIVSNPPYVDAEDFADMPAEFH-HEPELGLACGDDGLDLVRRMLAEAADH 244
Cdd:COG2890 154 RNAERLGLEDRVRFLQGDLFEPLPGdGRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRL 233

                       250       260       270
                ....*....|....*....|....*....|...
gi 15596875 245 LSEKGLLIVEVGNS-EVHVQALYPEVDFTWLEF 276
Cdd:COG2890 234 LKPGGWLLLEIGEDqGEAVRALLEAAGFADVET 266
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 8-256 6.23e-68

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 212.71  E-value: 6.23e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875    8 TLRDYIRWAVSRFHAAGLffghgtdnawdEARHLVLGSLHLPWEISDSYLDCRLEDDERAELAEILRRRIEeRIPAAYLL 87
Cdd:PRK09328   3 TIAEALREATARLASPRL-----------DAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAA-GEPLQYIL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   88 GEAWFCGIPFSVDERVLVPRSPIAELIEQRFAPWLPAEPARILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVANV 167
Cdd:PRK09328  71 GEAEFWGLDFKVSPGVLIPRPETEELVEWALEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARR 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875  168 NIERHdLGERVYTVQGDGFAGLPGQRFDLIVSNPPYVDAEDFADMPAE-FHHEPELGLACGDDGLDLVRRMLAEAADHLS 246
Cdd:PRK09328 151 NAKHG-LGARVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEvRDHEPHLALFGGEDGLDFYRRIIEQAPRYLK 229

                        250
                 ....*....|
gi 15596875  247 EKGLLIVEVG 256
Cdd:PRK09328 230 PGGWLLLEIG 239
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 118-258 5.81e-21

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 87.65  E-value: 5.81e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   118 FAPWLPAEPA-RILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVANVNIERHDLgERVYTVQGDGFAGLPGQRFDL 196
Cdd:pfam05175  23 LLEHLPKDLSgKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGL-ENGEVVASDVYSGVEDGKFDL 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596875   197 IVSNPPyvdaedfadmpaeFHhepelglACGDDGLDLVRRMLAEAADHLSEKGLLIVeVGNS 258
Cdd:pfam05175 102 IISNPP-------------FH-------AGLATTYNVAQRFIADAKRHLRPGGELWI-VANR 142
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 128-255 2.41e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 51.28  E-value: 2.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 128 RILDLCTGSGCIGIAcAYAFEQAEVVLADLSFDALEVAnVNIERHDLGERVYTVQGDGFAGL--PGQRFDLIVSNPPyvd 205
Cdd:cd02440   1 RVLDLGCGTGALALA-LASGPGARVTGVDISPVALELA-RKAAAALLADNVEVLKGDAEELPpeADESFDVIISDPP--- 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15596875 206 aedfadmpaeFHHEPElglacgddgldLVRRMLAEAADHLSEKGLLIVEV 255
Cdd:cd02440  76 ----------LHHLVE-----------DLARFLEEARRLLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 6-288 0e+00

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 527.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875     6 LLTLRDYIRWAVSRFHAAGLFFGHGTDNAWDEARHLVLGSLHLPWEISDSYLDCRLEDDERAELAEILRRRIEERIPAAY 85
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875    86 LLGEAWFCGIPFSVDERVLVPRSPIAELIEQRFAPWL-PAEPARILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEV 164
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLePEPVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   165 ANVNIERHDLGERVYTVQGDGFAGLPGQRFDLIVSNPPYVDAEDFADMPAEFHHEPELGLACGDDGLDLVRRMLAEAADH 244
Cdd:TIGR03533 161 AEINIERHGLEDRVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDMADLPAEYHHEPELALASGEDGLDLVRRILAEAADH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 15596875   245 LSEKGLLIVEVGNSEVHVQALYPEVDFTWLEFEHGGHGVFMLSA 288
Cdd:TIGR03533 241 LNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 8-276 1.36e-103

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 304.00  E-value: 1.36e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   8 TLRDYIRWAVSRFHAAGlffghgTDNAWDEARHLVLGSLHLPWEISDSYLDCRLEDDERAELAEILRRRiEERIPAAYLL 87
Cdd:COG2890   2 TIRELLRWAAARLAAAG------VDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARR-AAGEPLAYIL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875  88 GEAWFCGIPFSVDERVLVPRSPIAELIEQRFApWLPA-EPARILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVAN 166
Cdd:COG2890  75 GEAEFYGLEFKVDPGVLIPRPETEELVELALA-LLPAgAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVAR 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 167 VNIERHDLGERVYTVQGDGFAGLPG-QRFDLIVSNPPYVDAEDFADMPAEFH-HEPELGLACGDDGLDLVRRMLAEAADH 244
Cdd:COG2890 154 RNAERLGLEDRVRFLQGDLFEPLPGdGRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRL 233

                       250       260       270
                ....*....|....*....|....*....|...
gi 15596875 245 LSEKGLLIVEVGNS-EVHVQALYPEVDFTWLEF 276
Cdd:COG2890 234 LKPGGWLLLEIGEDqGEAVRALLEAAGFADVET 266
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 8-280 1.42e-92

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 276.16  E-value: 1.42e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875     8 TLRDYIRWAVSRFHAAGLFfghgtDNAWDEARHLVLGSLHLPWEISDSYLDCRLEDDERAELAEILRRRIEErIPAAYLL 87
Cdd:TIGR00536   2 TIQEFLRWASSALSRAIAR-----ENPWLEALLLLEHDLGRERDLLLAFLTEELTPDEKERIFRLVLRRVKG-VPVAYLL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875    88 GEAWFCGIPFSVDERVLVPRSPIAELIEQRFAPWLPAEPA-RILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVAN 166
Cdd:TIGR00536  76 GSKEFYGLEFFVNEHVLIPRPETEELVEKALASLISQPPIlHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   167 VNIERHDLGERVYTVQGDGFAGLPGQRFDLIVSNPPYVDAEDFADMPAEFHHEPELGLACGDDGLDLVRRMLAEAADHLS 246
Cdd:TIGR00536 156 ENAEKNQLEHRVEFIQSNLFEPLAGQKIDIIVSNPPYIDEEDLADLPNVVRFEPLLALVGGDDGLNILRQIIELAPDYLK 235

                         250       260       270
                  ....*....|....*....|....*....|....
gi 15596875   247 EKGLLIVEVGNSEVHVQALYPEVDFTWLEFEHGG 280
Cdd:TIGR00536 236 PNGFLVCEIGNWQQKSLKELLRIKFTWYDVENGR 269
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 8-256 6.23e-68

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 212.71  E-value: 6.23e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875    8 TLRDYIRWAVSRFHAAGLffghgtdnawdEARHLVLGSLHLPWEISDSYLDCRLEDDERAELAEILRRRIEeRIPAAYLL 87
Cdd:PRK09328   3 TIAEALREATARLASPRL-----------DAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAA-GEPLQYIL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   88 GEAWFCGIPFSVDERVLVPRSPIAELIEQRFAPWLPAEPARILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVANV 167
Cdd:PRK09328  71 GEAEFWGLDFKVSPGVLIPRPETEELVEWALEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARR 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875  168 NIERHdLGERVYTVQGDGFAGLPGQRFDLIVSNPPYVDAEDFADMPAE-FHHEPELGLACGDDGLDLVRRMLAEAADHLS 246
Cdd:PRK09328 151 NAKHG-LGARVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEvRDHEPHLALFGGEDGLDFYRRIIEQAPRYLK 229

                        250
                 ....*....|
gi 15596875  247 EKGLLIVEVG 256
Cdd:PRK09328 230 PGGWLLLEIG 239
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 37-256 6.48e-64

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 201.54  E-value: 6.48e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875    37 EARHLVLGSLHLP--WEISdsYLDCRLEDDERAELAEILRRRiEERIPAAYLLGEAWFCGIPFSVDERVLVPRSPIAELI 114
Cdd:TIGR03534   1 DAELLLAHVLGKDraQLLL--HPEDELTPEELAAFDALLARR-AAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   115 EQrFAPWLPAEPaRILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVANVNIERHDLgERVYTVQGDGFAGLPGQRF 194
Cdd:TIGR03534  78 EA-ALERLKKGP-RVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGL-ENVEFLQGDWFEPLPSGKF 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15596875   195 DLIVSNPPYVDAEDFADMPAE-FHHEPELGLACGDDGLDLVRRMLAEAADHLSEKGLLIVEVG 256
Cdd:TIGR03534 155 DLIVSNPPYIPEADIHLLDPEvRDFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIG 217
PrmC_rel_meth TIGR03704
putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein ...
 17-256 1.11e-29

putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein family is closely related to two different families of protein-(glutamine-N5) methyltransferase. The first is PrmB, which modifies ribosomal protein L3 in some bacteria. The second is PrmC (HemK), which modifies peptide chain release factors 1 and 2 in most bacteria and also in eukaryotes. The glutamine side chain-binding motif NPPY shared by PrmB and PrmC is N[VAT]PY in this family. The protein substrate is unknown. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274733 [Multi-domain]  Cd Length: 251  Bit Score: 112.95  E-value: 1.11e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875    17 VSRFHAAGLFFghgtdnAWDEARhLVLGSLHLPweisdsyldcrledderAELAEILRRRIEErIPAAYLLGEAWFCGIP 96
Cdd:TIGR03704   2 VTRLRAAGCVF------AEDEAA-LLVDAARTP-----------------GELAAMVDRRVAG-LPLEHVLGWAEFCGLR 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875    97 FSVDERVLVPRSPIAELIEQRFAPWLPAEPAR-ILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVANVNIERHdlG 175
Cdd:TIGR03704  57 IAVDPGVFVPRRRTEFLVDEAAALARPRSGTLvVVDLCCGSGAVGAALAAALDGIELHAADIDPAAVRCARRNLADA--G 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   176 ERVYtvQGDGFAGLPGQ---RFDLIVSNPPYVDAEDFADMPAEFH-HEPELGLACGDDGLDLVRRMLAEAADHLSEKGLL 251
Cdd:TIGR03704 135 GTVH--EGDLYDALPTAlrgRVDILAANAPYVPTDAIALMPPEARdHEPRVALDGGADGLDVLRRVAAGAPDWLAPGGHL 212


                  ....*
gi 15596875   252 IVEVG 256
Cdd:TIGR03704 213 LVETS 217
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 37-259 1.21e-29

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 117.66  E-value: 1.21e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   37 EARHLVLGSLHLPWEISDSYLDCRLEDDERAELAEILRRRIEERiPAAYLLGEAWFCGIPFSVDERVLVPRSPIAELIE- 115
Cdd:PRK01544  27 EARILLQHVINKPIEYLLINLDEQLNEAEIEAFEKLLERRLKHE-PIAYITGVKEFYSREFIVNKHVLIPRSDTEVLVDv 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875  116 -----------------------QRFAPWLPAEPARILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVANVNIERH 172
Cdd:PRK01544 106 vfqchsresgnpekkqlnpcfrgNDISSNCNDKFLNILELGTGSGCIAISLLCELPNANVIATDISLDAIEVAKSNAIKY 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875  173 DLGERVYTVQGDGFAGLPGQRFDLIVSNPPYVDAEDFADMPAE-FHHEPELGLACGDDGLDLVRRMLAEAADHLSEKGLL 251
Cdd:PRK01544 186 EVTDRIQIIHSNWFENIEKQKFDFIVSNPPYISHSEKSEMAIEtINYEPSIALFAEEDGLQAYFIIAENAKQFLKPNGKI 265


                 ....*...
gi 15596875  252 IVEVGNSE 259
Cdd:PRK01544 266 ILEIGFKQ 273
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 61-275 4.65e-24

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 100.93  E-value: 4.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   61 LEDDERAELAEILRRRIEERiPAAYLLGEAWFCGIPFSVDERVLVPRSPIAELIEQRFAPwLPaEPARILDLCTGSGCIG 140
Cdd:PRK14966 190 MPDEVRQRADRLAQRRLNGE-PVAYILGVREFYGRRFAVNPNVLIPRPETEHLVEAVLAR-LP-ENGRVWDLGTGSGAVA 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875  141 IACAYAFEQAEVVLADLSFDALEVANVNIErhDLGERVYTVQGDGF-AGLPGQ-RFDLIVSNPPYVDAEDFADMPAEFHH 218
Cdd:PRK14966 267 VTVALERPDAFVRASDISPPALETARKNAA--DLGARVEFAHGSWFdTDMPSEgKWDIIVSNPPYIENGDKHLLQGDLRF 344

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15596875  219 EPELGLACGDDGLDLVRRMLAEAADHLSEKGLLIVEVG-NSEVHVQALYPEVDFTWLE 275
Cdd:PRK14966 345 EPQIALTDFSDGLSCIRTLAQGAPDRLAEGGFLLLEHGfDQGAAVRGVLAENGFSGVE 402
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 122-258 1.11e-23

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 95.26  E-value: 1.11e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 122 LPAEPA-RILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVANVNIERHDLgERVYTVQGDGFAGLPGQRFDLIVSN 200
Cdd:COG2813  45 LPEPLGgRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGL-ENVEVLWSDGLSGVPDGSFDLILSN 123

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15596875 201 PPyvdaedfadmpaeFHHepelGLACGDdglDLVRRMLAEAADHLSEKGLLIVeVGNS 258
Cdd:COG2813 124 PP-------------FHA----GRAVDK---EVAHALIADAARHLRPGGELWL-VANR 160
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 118-258 5.81e-21

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 87.65  E-value: 5.81e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   118 FAPWLPAEPA-RILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVANVNIERHDLgERVYTVQGDGFAGLPGQRFDL 196
Cdd:pfam05175  23 LLEHLPKDLSgKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGL-ENGEVVASDVYSGVEDGKFDL 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596875   197 IVSNPPyvdaedfadmpaeFHhepelglACGDDGLDLVRRMLAEAADHLSEKGLLIVeVGNS 258
Cdd:pfam05175 102 IISNPP-------------FH-------AGLATTYNVAQRFIADAKRHLRPGGELWI-VANR 142
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 121-253 1.67e-17

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 79.80  E-value: 1.67e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 121 WLPAEPA-RILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVANVNIERHDLGERVYTVQGD---GFAGLPGQRFDL 196
Cdd:COG4123  32 FAPVKKGgRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDRITVIHGDlkeFAAELPPGSFDL 111

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15596875 197 IVSNPPYvdaedfadmpaefhHEPELGLACGDDGLDLVRRM--------LAEAADHLSEKGLLIV 253
Cdd:COG4123 112 VVSNPPY--------------FKAGSGRKSPDEARAIARHEdaltledlIRAAARLLKPGGRFAL 162
PRK14968 PRK14968
putative methyltransferase; Provisional
 128-249 2.80e-14

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 69.93  E-value: 2.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875  128 RILDLCTGSGCIGIACAyaFEQAEVVLADLSFDALEVANVNIERHDLGER-VYTVQGDGFAGLPGQRFDLIVSNPPYvda 206
Cdd:PRK14968  26 RVLEVGTGSGIVAIVAA--KNGKKVVGVDINPYAVECAKCNAKLNNIRNNgVEVIRSDLFEPFRGDKFDVILFNPPY--- 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 15596875  207 edfadMPAEFHHEPE--LGLAC--GDDGLDLVRRMLAEAADHLSEKG 249
Cdd:PRK14968 101 -----LPTEEEEEWDdwLNYALsgGKDGREVIDRFLDEVGRYLKPGG 142
PRK14967 PRK14967
putative methyltransferase; Provisional
 127-253 2.85e-13

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 67.77  E-value: 2.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875  127 ARILDLCTGSGCIGIACAYAfEQAEVVLADLSFDALEVANVNIERHdlGERVYTVQGDGFAGLPGQRFDLIVSNPPYVda 206
Cdd:PRK14967  38 RRVLDLCTGSGALAVAAAAA-GAGSVTAVDISRRAVRSARLNALLA--GVDVDVRRGDWARAVEFRPFDVVVSNPPYV-- 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15596875  207 edfadmPAEFHHEPELGLA----CGDDGLDLVRRMLAEAADHLSEKGLLIV 253
Cdd:PRK14967 113 ------PAPPDAPPSRGPArawdAGPDGRAVLDRLCDAAPALLAPGGSLLL 157
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 127-254 4.45e-10

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 57.78  E-value: 4.45e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 127 ARILDLCTGSGCIGIACA--YAfeqAEVVLADLSFDALEVANVNIERHDLGERVYTVQGDGF---AGLPGQRFDLIVSNP 201
Cdd:COG0742  43 ARVLDLFAGSGALGLEALsrGA---ASVVFVEKDRKAAAVIRKNLEKLGLEDRARVIRGDALrflKRLAGEPFDLVFLDP 119

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15596875 202 PYvdaedfadmpaefhhepelglacgddGLDLVRRMLA--EAADHLSEKGLLIVE 254
Cdd:COG0742 120 PY--------------------------AKGLLEKALEllAENGLLAPGGLIVVE 148
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 125-253 5.54e-10

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 57.56  E-value: 5.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   125 EPARILDLCTGSGCIGIACAYafEQAEVVLADLSFDALEVANVNIERHDLGERVytVQGDGFAGLPGqRFDLIVSNPPYV 204
Cdd:TIGR00537  19 KPDDVLEIGAGTGLVAIRLKG--KGKCILTTDINPFAVKELRENAKLNNVGLDV--VMTDLFKGVRG-KFDVILFNPPYL 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15596875   205 DAEDfadmpaEFHHEPELGLAC--GDDGLDLVRRMLAEAADHLSEKGLLIV 253
Cdd:TIGR00537  94 PLED------DLRRGDWLDVAIdgGKDGRKVIDRFLDELPEILKEGGRVQL 138
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
128-213 5.97e-09

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 54.91  E-value: 5.97e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 128 RILDLCTGSGCIGIACAYAfeQAEVVLA-DLSFDALEVANVNIERhdLGERVYTVQGDGFAGLPGQRFDLIVSNPPYVDA 206
Cdd:COG2263  48 TVLDLGCGTGMLAIGAALL--GAKKVVGvDIDPEALEIARENAER--LGVRVDFIRADVTRIPLGGSVDTVVMNPPFGAQ 123


                ....*..
gi 15596875 207 EDFADMP 213
Cdd:COG2263 124 RRHADRP 130
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 128-255 2.41e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 51.28  E-value: 2.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 128 RILDLCTGSGCIGIAcAYAFEQAEVVLADLSFDALEVAnVNIERHDLGERVYTVQGDGFAGL--PGQRFDLIVSNPPyvd 205
Cdd:cd02440   1 RVLDLGCGTGALALA-LASGPGARVTGVDISPVALELA-RKAAAALLADNVEVLKGDAEELPpeADESFDVIISDPP--- 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15596875 206 aedfadmpaeFHHEPElglacgddgldLVRRMLAEAADHLSEKGLLIVEV 255
Cdd:cd02440  76 ----------LHHLVE-----------DLARFLEEARRLLKPGGVLVLTL 104
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 116-202 1.83e-07

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 51.72  E-value: 1.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 116 QRFAPWlpAEPARILDLCTGSGCIGIACAyAFEQAEVVLADLSFDALEVANVNIERHDLGERVYTVQGDGFAGL-----P 190
Cdd:COG1092 209 ARVAEL--AKGKRVLNLFSYTGGFSVHAA-AGGAKSVTSVDLSATALEWAKENAALNGLDDRHEFVQADAFDWLrelarE 285

                        90
                ....*....|..
gi 15596875 191 GQRFDLIVSNPP 202
Cdd:COG1092 286 GERFDLIILDPP 297
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
125-255 2.07e-07

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 48.28  E-value: 2.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 125 EPARILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVANvniERHDlgeRVYTVQGDGFAGLPGQRFDLIVSNppyv 204
Cdd:COG4106   1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARAR---ARLP---NVRFVVADLRDLDPPEPFDLVVSN---- 70

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15596875 205 daedfadmpAEFHHEPELglacgddgldlvRRMLAEAADHLSEKGLLIVEV 255
Cdd:COG4106  71 ---------AALHWLPDH------------AALLARLAAALAPGGVLAVQV 100
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 129-249 7.06e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 46.79  E-value: 7.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   129 ILDLCTGSGCIGIACAYAFeQAEVVLADLSFDALEVANVNIERHDLgeRVYTVQGDGFA-GLPGQRFDLIVSNppyvdae 207
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDlPFPDGSFDLVVSS------- 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 15596875   208 dfadmpAEFHHEPElglacgddglDLVRRMLAEAADHLSEKG 249
Cdd:pfam13649  71 ------GVLHHLPD----------PDLEAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 110-257 1.56e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 46.55  E-value: 1.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 110 IAELIEQRFAPwlpaePARILDLCTGSGCIGIACAYAFeqAEVVLADLSFDALEVAnvniERHDLGERVYTVQGDGFA-G 188
Cdd:COG2227  14 LAALLARLLPA-----GGRVLDVGCGTGRLALALARRG--ADVTGVDISPEALEIA----RERAAELNVDFVQGDLEDlP 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596875 189 LPGQRFDLIVSNppYVdaedfadmpaeFHHEPELglacgddgldlvRRMLAEAADHLSEKGLLIVEVGN 257
Cdd:COG2227  83 LEDGSFDLVICS--EV-----------LEHLPDP------------AALLRELARLLKPGGLLLLSTPN 126
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 116-253 1.61e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 46.91  E-value: 1.61e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 116 QRFAPWLPAEP-ARILDLCTGSGciGIACAYAFEQAEVVLADLSFDALEVANVNIErhDLGERVYTVQGDGFA-GLPGQR 193
Cdd:COG2226  12 EALLAALGLRPgARVLDLGCGTG--RLALALAERGARVTGVDISPEMLELARERAA--EAGLNVEFVVGDAEDlPFPDGS 87

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 194 FDLIVSNppyvdaedFAdmpaeFHHEPELglacgddgldlvRRMLAEAADHLSEKGLLIV 253
Cdd:COG2226  88 FDLVISS--------FV-----LHHLPDP------------ERALAEIARVLKPGGRLVV 122
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
112-200 3.65e-06

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 47.48  E-value: 3.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 112 ELIEQrfapwLPAEPARILDLCTGSGCIGIACAYAFeqAEVVLA-DLSFDALEVANVNIERHDLGERVYTVQGDgfaGLP 190
Cdd:COG2264 140 EALEK-----LLKPGKTVLDVGCGSGILAIAAAKLG--AKRVLAvDIDPVAVEAARENAELNGVEDRIEVVLGD---LLE 209

                        90
                ....*....|
gi 15596875 191 GQRFDLIVSN 200
Cdd:COG2264 210 DGPYDLVVAN 219
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
128-253 4.40e-06

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 47.63  E-value: 4.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875  128 RILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVANVNIERHDLGERVYTvqGDGFAGLPGqRFDLIVSNPPyvdae 207
Cdd:PRK09489 199 KVLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALESSRATLAANGLEGEVFA--SNVFSDIKG-RFDMIISNPP----- 270

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15596875  208 dfadmpaeFHhepelglacgdDGLD----LVRRMLAEAADHLSEKG-LLIV 253
Cdd:PRK09489 271 --------FH-----------DGIQtsldAAQTLIRGAVRHLNSGGeLRIV 302
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
110-203 3.44e-05

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 44.41  E-value: 3.44e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 110 IAELIEqrfapwlPAEPARILDLCTGSGCIGIACA-YAFEQAEVVLADLSF-------DALEVANVNIERHDLGE-RVYt 180
Cdd:COG0286  35 MVELLD-------PKPGETVYDPACGSGGFLVEAAeYLKEHGGDERKKLSLygqeinpTTYRLAKMNLLLHGIGDpNIE- 106

                        90       100
                ....*....|....*....|....*
gi 15596875 181 vQGDGFA--GLPGQRFDLIVSNPPY 203
Cdd:COG0286 107 -LGDTLSndGDELEKFDVVLANPPF 130
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 128-200 1.23e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 41.63  E-value: 1.23e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596875   128 RILDLCTGSGCIGIACAY-AFEQAEVVLADLSFDALEVANVNIERHDLgERVYTVQGDGFA---GLPGQRFDLIVSN 200
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEeLGPNAEVVGIDISEEAIEKARENAQKLGF-DNVEFEQGDIEElpeLLEDDKFDVVISN 81
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 121-202 1.50e-04

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 42.86  E-value: 1.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 121 WL-PAEPARILDLCTGSGCIGIACAYAFeqAEVVLADLSFDALEVANVNIERHDLgERVYTVQGDGFAGLP----GQRFD 195
Cdd:COG2265 228 WLdLTGGERVLDLYCGVGTFALPLARRA--KKVIGVEIVPEAVEDARENARLNGL-KNVEFVAGDLEEVLPellwGGRPD 304


                ....*..
gi 15596875 196 LIVSNPP 202
Cdd:COG2265 305 VVVLDPP 311
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 116-253 1.64e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 41.45  E-value: 1.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 116 QRFAPWLPAEP-ARILDLCTGSGCIGIACAYAFeQAEVVLADLSFDALEVANVNIERHDLGERVYTVQGDGFAGLPGQRF 194
Cdd:COG2230  41 DLILRKLGLKPgMRVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPADGQF 119

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15596875 195 DLIVSNppyvdaedfaDMpaeFHHEPElglacgddglDLVRRMLAEAADHLSEKGLLIV 253
Cdd:COG2230 120 DAIVSI----------GM---FEHVGP----------ENYPAYFAKVARLLKPGGRLLL 155
PRK15001 PRK15001
23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;
129-218 2.73e-04

23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;


Pssm-ID: 184963 [Multi-domain]  Cd Length: 378  Bit Score: 41.94  E-value: 2.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875  129 ILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVANVNIERH--DLGERVYTVQGDGFAGLPGQRFDLIVSNPPYVDA 206
Cdd:PRK15001 232 IVDLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVETNmpEALDRCEFMINNALSGVEPFRFNAVLCNPPFHQQ 311

                         90
                 ....*....|....
gi 15596875  207 EDFADMPA--EFHH 218
Cdd:PRK15001 312 HALTDNVAweMFHH 325
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 125-200 3.04e-04

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 41.50  E-value: 3.04e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596875   125 EPARILDLCTGSGCIGIACAYAFEQAEVVLADLSFDALEVAnvnieRHDLGERVYTVQGDG-FAGLPGQRFDLIVSN 200
Cdd:TIGR02072  34 IPASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQA-----KTKLSENVQFICGDAeKLPLEDSSFDLIVSN 105
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 125-203 4.89e-04

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 39.93  E-value: 4.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 125 EPARILDLCTGSGCIGIACAYAfeQAEVVLADLSFDALEVANVNIErHDLGERVYTVQGDGFA-GLPGQRFDLIVSNPPY 203
Cdd:COG1041  26 EGDTVLDPFCGTGTILIEAGLL--GRRVIGSDIDPKMVEGARENLE-HYGYEDADVIRGDARDlPLADESVDAIVTDPPY 102
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
127-199 4.92e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 40.79  E-value: 4.92e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15596875 127 ARILDLCTGSGCIGIACAYAfEQAEVVLADLSFDALEVANVNIERHDLGERVYTVQGDGFAGLPGQRFDLIVS 199
Cdd:COG4076  37 DVVLDIGTGSGLLSMLAARA-GAKKVYAVEVNPDIAAVARRIIAANGLSDRITVINADATDLDLPEKADVIIS 108
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 123-197 5.68e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 40.52  E-value: 5.68e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596875  123 PAEPARILDLCTGSGCIGIA-CAYAFEQAEVVLADLSFDALEVANVNIERHDLGERVYTVQGDGFA-GLPGQRFDLI 197
Cdd:PRK00216  49 VRPGDKVLDLACGTGDLAIAlAKAVGKTGEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEAlPFPDNSFDAV 125
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 125-198 6.04e-04

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 40.01  E-value: 6.04e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596875   125 EPARILDLCTGSGCIGIACAYAFEQAEVVLADLSfDALEVANVNIERHDLGERVYTVQGD-----GFAGLPGQRFDLIV 198
Cdd:pfam10294  46 SGLNVLELGSGTGLVGIAVALLLPGASVTITDLE-EALELLKKNIELNALSSKVVVKVLDwgenlPPDLFDGHPVDLIL 123
PrmC_N pfam17827
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the ...
 13-88 6.59e-04

PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors.


Pssm-ID: 436073 [Multi-domain]  Cd Length: 71  Bit Score: 37.46  E-value: 6.59e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596875    13 IRWAVSRFHAAGLffghgtDNAWDEARHLVLGSLHlpWEISDSYL--DCRLEDDERAELAEILRRRIEeRIPAAYLLG 88
Cdd:pfam17827   3 LRWASSRLKEAGI------ESPRLDAELLLAHVLG--LDRTDLLLhpEEELSEEELERFEELLERRAA-GEPLQYILG 71
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
125-203 6.73e-04

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 39.91  E-value: 6.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   125 EPARILDLCTGSGCIGI--ACAYAfeqAEVVLADLSFDALEVANVNIERHDLGERVYtVQGDGFAGL----PGQRFDLIV 198
Cdd:pfam03602  41 EGARVLDLFAGSGALGLeaLSRGA---KRVTLVEKDKRAVQILKENLQLLGLPGAVL-VMDALLALLrlagKGPVFDIVF 116


                  ....*
gi 15596875   199 SNPPY 203
Cdd:pfam03602 117 LDPPY 121
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 117-203 9.56e-04

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 39.26  E-value: 9.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   117 RFAPWLPAEParILDLCTGSGCI-------GIACAYAFEQAEVVL----ADLSFDALEVANVNIERHDLGERVYTVQGDg 185
Cdd:pfam01170  22 NLAGWKPGDP--LLDPMCGSGTIlieaalmGANIAPGKFDARVRAplygSDIDRRMVQGARLNAENAGVGDLIEFVQAD- 98

                          90       100
                  ....*....|....*....|
gi 15596875   186 FAGLPGQR--FDLIVSNPPY 203
Cdd:pfam01170  99 AADLPLLEgsVDVIVTNPPY 118
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
111-259 1.27e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 38.83  E-value: 1.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 111 AELIEQRFAPWLPAEPARILDLCTGSGCIGIACAYAFeqAEVVLADLSFDALEVAnvniERHDLGERVYtvQGDgFAGL- 189
Cdd:COG4976  32 ALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRG--YRLTGVDLSEEMLAKA----REKGVYDRLL--VAD-LADLa 102

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596875 190 -PGQRFDLIVSnppyvdaedfADMpaeFHHEPELglacgddgldlvRRMLAEAADHLSEKGLLIVEVGNSE 259
Cdd:COG4976 103 ePDGRFDLIVA----------ADV---LTYLGDL------------AAVFAGVARALKPGGLFIFSVEDAD 148
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
125-200 2.28e-03

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 38.98  E-value: 2.28e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596875  125 EPARILDLCTGSGCIGIACAY--AfeqAEVVLADLSFDALEVANVNIERHDLGERVYTVQGDgfaglpgQRFDLIVSN 200
Cdd:PRK00517 119 PGKTVLDVGCGSGILAIAAAKlgA---KKVLAVDIDPQAVEAARENAELNGVELNVYLPQGD-------LKADVIVAN 186
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 128-211 3.74e-03

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 38.30  E-value: 3.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875 128 RILDLCTGSGCIGIACAyAFEQAEVVLADLSFDALEVANVNIERHDLGERVYTVQGDG--FAGLPGQRFDLIVSNPPYvD 205
Cdd:COG2520 183 RVLDMFAGVGPFSIPIA-KRSGAKVVAIDINPDAVEYLKENIRLNKVEDRVTPILGDAreVAPELEGKADRIIMNLPH-S 260


                ....*.
gi 15596875 206 AEDFAD 211
Cdd:COG2520 261 ADEFLD 266
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 116-285 5.92e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 36.64  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   116 QRFAPWLPAePARILDLCTGSGCIGIACAYafEQAEVVLADLSFDALEVANVNIERHDLGERVYTVqgdgfaglPGQRFD 195
Cdd:pfam13489  14 LRLLPKLPS-PGRVLDFGCGTGIFLRLLRA--QGFSVTGVDPSPIAIERALLNVRFDQFDEQEAAV--------PAGKFD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596875   196 LIVSNppYVdAEDFADMPAEFHHepelglacgddgldlvrrmlaeAADHLSEKGLLIVEVGNSEVHVQALYPEVdftWLE 275
Cdd:pfam13489  83 VIVAR--EV-LEHVPDPPALLRQ----------------------IAALLKPGGLLLLSTPLASDEADRLLLEW---PYL 134

                         170
                  ....*....|
gi 15596875   276 FEHGGHGVFM 285
Cdd:pfam13489 135 RPRNGHISLF 144
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
128-202 6.68e-03

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 37.58  E-value: 6.68e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596875 128 RILDLCTGSGCIGIACAyAFEQAEVVLADLSFDALEVANVNIERHDL-GERVYTVQGDGFAG---LPGQRFDLIVSNPP 202
Cdd:COG2521 135 RVLDTCTGLGYTAIEAL-KRGAREVITVEKDPNVLELAELNPWSRELaNERIKIILGDASEViktFPDESFDAIIHDPP 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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