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Conserved domains on  [gi|15596885|ref|NP_250379|]
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hypothetical protein PA1688 [Pseudomonas aeruginosa PAO1]

Protein Classification

YncE family protein( domain architecture ID 11465355)

YncE family protein contains repeats resembling the NHL (NCL-1, HT2A and LIN-41) and YVTN-type repeats, similar to DNA-binding beta-propeller protein YncE and Bacillus subtilis uncharacterized protein YwhL

CATH:  2.130.10.10
PubMed:  22120742|10607670
SCOP:  4002745

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vgb super family cl26743
Streptogramin lyase [Defense mechanisms];
32-240 5.93e-09

Streptogramin lyase [Defense mechanisms];


The actual alignment was detected with superfamily member COG4257:

Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 55.80  E-value: 5.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885  32 RFAPAatvSGWTYRVVLEDIPHVSALARDPDGLLYVSQELQdgkGLVFRI-AADGSRDTVL--DGLSKPDGMASFRDGIA 108
Cdd:COG4257  42 RLDPA---TGEFTEYPLGGGSGPHGIAVDPDGNLWFTDNGN---NRIGRIdPKTGEITTFAlpGGGSNPHGIAFDPDGNL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 109 ISQEQGASPV------------FWWHAQQARPlfDGIqveGVASDGRyLYAAEDRDldGRILRYDPETGGLTV--LREGL 174
Cdd:COG4257 116 WFTDQGGNRIgrldpatgevteFPLPTGGAGP--YGI---AVDPDGN-LWVTDFGA--NAIGRIDPDTGTLTEyaLPTPG 187

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 175 QRSEGVAACPDGSVFYTEKKRGHVMRL--HEGAEDEVVLNGLNA-PSFLLCDSEG-LWITEDSTHNARAL 240
Cdd:COG4257 188 AGPRGLAVDPDGNLWVADTGSGRIGRFdpKTGTVTEYPLPGGGArPYGVAVDGDGrVWFAESGANRIVRF 257
 
Name Accession Description Interval E-value
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
32-240 5.93e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 55.80  E-value: 5.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885  32 RFAPAatvSGWTYRVVLEDIPHVSALARDPDGLLYVSQELQdgkGLVFRI-AADGSRDTVL--DGLSKPDGMASFRDGIA 108
Cdd:COG4257  42 RLDPA---TGEFTEYPLGGGSGPHGIAVDPDGNLWFTDNGN---NRIGRIdPKTGEITTFAlpGGGSNPHGIAFDPDGNL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 109 ISQEQGASPV------------FWWHAQQARPlfDGIqveGVASDGRyLYAAEDRDldGRILRYDPETGGLTV--LREGL 174
Cdd:COG4257 116 WFTDQGGNRIgrldpatgevteFPLPTGGAGP--YGI---AVDPDGN-LWVTDFGA--NAIGRIDPDTGTLTEyaLPTPG 187

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 175 QRSEGVAACPDGSVFYTEKKRGHVMRL--HEGAEDEVVLNGLNA-PSFLLCDSEG-LWITEDSTHNARAL 240
Cdd:COG4257 188 AGPRGLAVDPDGNLWVADTGSGRIGRFdpKTGTVTEYPLPGGGArPYGVAVDGDGrVWFAESGANRIVRF 257
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 44-106 1.93e-06

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 48.43  E-value: 1.93e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596885   44 YRVVLEDIPHVSA--------LARDPDGLLYVSQ------ELQDGKGLVFRIAADGSRDTVLDGLSKPDGMASFRDG 106
Cdd:NF033206 234 YRVDPGGAPTVYAtgftgltdLAFDPDGNLYVLElaggglLKGDPTGSLIRIAPDGTRTTLLDGLELPTGLAVGPDG 310
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 130-244 7.30e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 43.35  E-value: 7.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 130 FDGIQV-EGVASD-GRYLYAAeDRDlDGRILRYDPETGGLTVLR-EGLQRSEGVAACPDGSVFYTEKKRGHVMRLHEGAE 206
Cdd:cd14952   6 FTGLDGpGGVAVDaAGNVYVA-DSG-NNRVLKLAAGSTTQTVLPfTGLYQPQGVAVDAAGTVYVTDFGNNRVLKLAAGST 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15596885 207 DEVVL--NGLNAPSFLLCDSEG-LWITEdsTHNARALLLPP 244
Cdd:cd14952  84 TQTVLpfTGLNDPTGVAVDAAGnVYVAD--TGNNRVLKLAA 122
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 144-187 9.93e-05

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 40.50  E-value: 9.93e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 15596885   144 YLYAAEDRDLDGRILRYDPETGGLTVLREGLQRSEGVAACPDGS 187
Cdd:pfam03088  26 VIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGS 69
 
Name Accession Description Interval E-value
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
32-240 5.93e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 55.80  E-value: 5.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885  32 RFAPAatvSGWTYRVVLEDIPHVSALARDPDGLLYVSQELQdgkGLVFRI-AADGSRDTVL--DGLSKPDGMASFRDGIA 108
Cdd:COG4257  42 RLDPA---TGEFTEYPLGGGSGPHGIAVDPDGNLWFTDNGN---NRIGRIdPKTGEITTFAlpGGGSNPHGIAFDPDGNL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 109 ISQEQGASPV------------FWWHAQQARPlfDGIqveGVASDGRyLYAAEDRDldGRILRYDPETGGLTV--LREGL 174
Cdd:COG4257 116 WFTDQGGNRIgrldpatgevteFPLPTGGAGP--YGI---AVDPDGN-LWVTDFGA--NAIGRIDPDTGTLTEyaLPTPG 187

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 175 QRSEGVAACPDGSVFYTEKKRGHVMRL--HEGAEDEVVLNGLNA-PSFLLCDSEG-LWITEDSTHNARAL 240
Cdd:COG4257 188 AGPRGLAVDPDGNLWVADTGSGRIGRFdpKTGTVTEYPLPGGGArPYGVAVDGDGrVWFAESGANRIVRF 257
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 32-230 2.31e-08

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 53.74  E-value: 2.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885  32 RFAPAatvsGWTYRVVLEDIPHVSALARDPDGLLYVSqelQDGKGLVFRIAADGSRDTVLDGLSKPdgMASFRDGIaisq 111
Cdd:COG3386  33 RYDPD----GGAVEVFAEPSGRPNGLAFDPDGRLLVA---DHGRGLVRFDPADGEVTVLADEYGKP--LNRPNDGV---- 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 112 eqgaspvfwwhaqqarplfdgiqvegVASDGRyLYAAE--DRDLDGRILRYDPeTGGLTVLREGLQRSEGVAACPDGSVF 189
Cdd:COG3386 100 --------------------------VDPDGR-LYFTDmgEYLPTGALYRVDP-DGSLRVLADGLTFPNGIAFSPDGRTL 151

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 15596885 190 Y-TEKKRGHVMR--LHEG---AEDEVVLNGLNAPSF---LLCDSEG-LWIT 230
Cdd:COG3386 152 YvADTGAGRIYRfdLDADgtlGNRRVFADLPDGPGGpdgLAVDADGnLWVA 202
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
36-279 2.46e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 50.79  E-value: 2.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885  36 AATVSGWTYRVVLEDIPHVSALARDPDGLLYVSqelQDGKGLVFRIA-ADGS-RDTVLDGLSKPDGMASFRDGIA----- 108
Cdd:COG4257   1 AASAVDITEYPVPAPGSGPRDVAVDPDGAVWFT---DQGGGRIGRLDpATGEfTEYPLGGGSGPHGIAVDPDGNLwftdn 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 109 -------ISQEQGASPVFWWHAQQARPLfdGIQvegVASDGRyLYAAEDRdlDGRILRYDPETGGLTV--LREGLQRSEG 179
Cdd:COG4257  78 gnnrigrIDPKTGEITTFALPGGGSNPH--GIA---FDPDGN-LWFTDQG--GNRIGRLDPATGEVTEfpLPTGGAGPYG 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 180 VAACPDGSVFYTEKKRGHVMRL--HEGAEDEVVL-NGLNAPSFLLCDSEG-LWITeDSTHNARALLLPPDGPLQVIVRRL 255
Cdd:COG4257 150 IAVDPDGNLWVTDFGANAIGRIdpDTGTLTEYALpTPGAGPRGLAVDPDGnLWVA-DTGSGRIGRFDPKTGTVTEYPLPG 228

                       250       260
                ....*....|....*....|....*....
gi 15596885 256 RSAQsllPIGP-----GRYLLAEQGRDRI 279
Cdd:COG4257 229 GGAR---PYGVavdgdGRVWFAESGANRI 254
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 44-106 1.93e-06

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 48.43  E-value: 1.93e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596885   44 YRVVLEDIPHVSA--------LARDPDGLLYVSQ------ELQDGKGLVFRIAADGSRDTVLDGLSKPDGMASFRDG 106
Cdd:NF033206 234 YRVDPGGAPTVYAtgftgltdLAFDPDGNLYVLElaggglLKGDPTGSLIRIAPDGTRTTLLDGLELPTGLAVGPDG 310
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 153-255 2.38e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.88  E-value: 2.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 153 LDGRILRYDPETGGLTVLREGLQRSEGVAACPDGSVFYTEKKRGhVMRLHEGAEDEVVL-----NGLNAPSFLLCDSEG- 226
Cdd:COG3386  27 PGGRIHRYDPDGGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRG-LVRFDPADGEVTVLadeygKPLNRPNDGVVDPDGr 105

                        90       100       110
                ....*....|....*....|....*....|.
gi 15596885 227 LWITE-DSTHNARALL-LPPDGPLQVIVRRL 255
Cdd:COG3386 106 LYFTDmGEYLPTGALYrVDPDGSLRVLADGL 136
YliI COG2133
Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];
16-191 5.68e-05

Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];


Pssm-ID: 441736 [Multi-domain]  Cd Length: 365  Bit Score: 44.15  E-value: 5.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885  16 LLGSVLFIALAFLGWQRFAPAATVSGWTYRVVLEDIPHVSALARDPDGLLYVSQelQDGKglVFRIAADGSRDTVLDGLS 95
Cdd:COG2133   1 LLAALLLAGCSPAGALPAPTPTLPPGFTVEVVADGLDHPWGLAFLPDGRLLVTE--RAGR--IRLLDDDGKLSTPVADLP 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885  96 KPDGMASFRDGIAIsqeqgaSPVFwwhaqqarplfdgiqvegvASDGR-YLYAAEDRDLDGRILRYDPETGGL----TVL 170
Cdd:COG2133  77 VFAGGEGGLLGVAL------DPDF-------------------ATNGYlYVAYTDPGGAGTRVARFTLSDGDTltseEVI 131

                       170       180
                ....*....|....*....|....*..
gi 15596885 171 REGLQRSEG------VAACPDGSVFYT 191
Cdd:COG2133 132 LDGLPAGGGnhnggrLAFGPDGKLYVS 158
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 130-244 7.30e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 43.35  E-value: 7.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 130 FDGIQV-EGVASD-GRYLYAAeDRDlDGRILRYDPETGGLTVLR-EGLQRSEGVAACPDGSVFYTEKKRGHVMRLHEGAE 206
Cdd:cd14952   6 FTGLDGpGGVAVDaAGNVYVA-DSG-NNRVLKLAAGSTTQTVLPfTGLYQPQGVAVDAAGTVYVTDFGNNRVLKLAAGST 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15596885 207 DEVVL--NGLNAPSFLLCDSEG-LWITEdsTHNARALLLPP 244
Cdd:cd14952  84 TQTVLpfTGLNDPTGVAVDAAGnVYVAD--TGNNRVLKLAA 122
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 144-187 9.93e-05

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 40.50  E-value: 9.93e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 15596885   144 YLYAAEDRDLDGRILRYDPETGGLTVLREGLQRSEGVAACPDGS 187
Cdd:pfam03088  26 VIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGS 69
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 57-243 1.15e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 42.58  E-value: 1.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885  57 LARDPDGLLYVSQELQDGkglVFRIAADGSRDTVL--DGLSKPDGMASFRDGIAISQEQGASPVFWWHAQQARPL---FD 131
Cdd:cd14952  57 VAVDAAGTVYVTDFGNNR---VLKLAAGSTTQTVLpfTGLNDPTGVAVDAAGNVYVADTGNNRVLKLAAGSNTQTvlpFT 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 132 GIQV-EGVASDGR-YLYAAeDRDLDgRILRYDPETGGLTVLR-EGLQRSEGVAACPDGSVFYTEKKRGHVMRLHEGAEDE 208
Cdd:cd14952 134 GLSNpDGVAVDGAgNVYVT-DTGNN-RVLKLAAGSTTQTVLPfTGLNSPSGVAVDTAGNVYVTDHGNNRVLKLAAGSTTP 211

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 15596885 209 VVL--NGLNAPSFLLCDSEG-LWITEDSthNARALLLP 243
Cdd:cd14952 212 TVLpfTGLNGPLGVAVDAAGnVYVADRG--NDRVVKLP 247
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 57-210 1.81e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.19  E-value: 1.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885  57 LARDPDGLLYVS-QELQDGKGLVFRIAADGSRDTVLDGLSKPDGMAsfrdgiaisqeqgaspvfwwhaqqarplfdgiqv 135
Cdd:COG3386  98 GVVDPDGRLYFTdMGEYLPTGALYRVDPDGSLRVLADGLTFPNGIA---------------------------------- 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 136 egVASDGRYLYAAEDRdlDGRILRYDP-ETGGLT------VLREGLQRSEGVAACPDGSVFYTEKKRGHVMRLH-EGAED 207
Cdd:COG3386 144 --FSPDGRTLYVADTG--AGRIYRFDLdADGTLGnrrvfaDLPDGPGGPDGLAVDADGNLWVALWGGGGVVRFDpDGELL 219


                ...
gi 15596885 208 EVV 210
Cdd:COG3386 220 GRI 222
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 141-219 1.83e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 41.20  E-value: 1.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 141 DGRYLYAAEDRDLDGRILRYDPETGGLTVLREGLQRSEGVAACPDGS-VFYTEKKRGH----VMRLhEGAEDEVVLNGLN 215
Cdd:COG0823  41 DGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASPSWSPDGKrLAFVSRSDGRfdiyVLDL-DGGAPRRLTDGPG 119


                ....
gi 15596885 216 APSF 219
Cdd:COG0823 120 SPSW 123
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 57-263 6.62e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 40.27  E-value: 6.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885  57 LARDPDGLLYVSQElqdGKGLVFRIAADGSRDTVL--DGLSKPDGMAsfrdgiaisqeqgaspvfwwhaqqarplfdgiq 134
Cdd:cd14952  15 VAVDAAGNVYVADS---GNNRVLKLAAGSTTQTVLpfTGLYQPQGVA--------------------------------- 58

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 135 vegVASDGRyLYAAedrDLD-GRILRYDPETGGLTVLR-EGLQRSEGVAACPDGSVFYTEKKRGHVMRLHEGAEDEVVL- 211
Cdd:cd14952  59 ---VDAAGT-VYVT---DFGnNRVLKLAAGSTTQTVLPfTGLNDPTGVAVDAAGNVYVADTGNNRVLKLAAGSNTQTVLp 131

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 15596885 212 -NGLNAPSFLLCDSEG-LWITeDSTHNaRALLLPPDGplqvivrrlrSAQSLLP 263
Cdd:cd14952 132 fTGLSNPDGVAVDGAGnVYVT-DTGNN-RVLKLAAGS----------TTQTVLP 173
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
57-187 5.17e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 37.96  E-value: 5.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885  57 LARDPDG-LLYVSQElQDGKGLVFRIAADGSrdtvldgLSKPDGMASFRDGIAISQEQGASpvfwwHAQQARplfdgiqv 135
Cdd:COG2706  98 LSVDPDGrFLFVANY-GGGSVSVFPIDADGS-------LGEPVQVIQHEGSGPNPERQEGP-----HAHSVV-------- 156

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15596885 136 egVASDGRYLYAAedrDLDG---RILRYDPETGGLTvlreglqrSEGVAACPDGS 187
Cdd:COG2706 157 --FDPDGRFLYVP---DLGTdriYVYRLDPATGKLP--------EPPEVSLPPGS 198
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 168-254 5.93e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 37.56  E-value: 5.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 168 TVLREGLQRSEGVAACPDGSVFYTEKKRGHVMRLHE-GAEDEVVLNGLNAPSFLLCDSEG-LWITEDsthnARALLL--P 243
Cdd:COG3386   1 KLADAGFRLGEGPVWDPDGRLYWVDIPGGRIHRYDPdGGAVEVFAEPSGRPNGLAFDPDGrLLVADH----GRGLVRfdP 76

                        90
                ....*....|.
gi 15596885 244 PDGPLQVIVRR 254
Cdd:COG3386  77 ADGEVTVLADE 87
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
179-282 7.26e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 37.31  E-value: 7.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596885 179 GVAACPDGSVFYTEKKRGHVMRLH--EGAEDEVVLNGLNAPSFLLCDSEG-LWITeDSTHNARALLLPPDGPLQVIV--R 253
Cdd:COG4257  21 DVAVDPDGAVWFTDQGGGRIGRLDpaTGEFTEYPLGGGSGPHGIAVDPDGnLWFT-DNGNNRIGRIDPKTGEITTFAlpG 99

                        90       100
                ....*....|....*....|....*....
gi 15596885 254 RLRSAQSLLPIGPGRYLLAEQGRDRILEI 282
Cdd:COG4257 100 GGSNPHGIAFDPDGNLWFTDQGGNRIGRL 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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