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Conserved domains on  [gi|15597027|ref|NP_250521|]
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hypothetical protein PA1830 [Pseudomonas aeruginosa PAO1]

Protein Classification

SCP2 sterol-binding domain-containing protein( domain architecture ID 10007129)

SCP2 sterol-binding domain-containing protein may have lipid-transfer activity, similar to Candida tropicalis oleate-induced peroxisomal protein POX18 and Arabidopsis thaliana sterol carrier protein 2

CATH:  3.30.1050.10
Gene Ontology:  GO:0008289
PubMed:  18084051|28284963|11330036
SCOP:  4000360

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCP2 COG3255
Putative sterol carrier protein, contains SCP2 domain [Lipid transport and metabolism];
5-103 9.56e-34

Putative sterol carrier protein, contains SCP2 domain [Lipid transport and metabolism];


:

Pssm-ID: 442486 [Multi-domain]  Cd Length: 104  Bit Score: 112.31  E-value: 9.56e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597027   5 ADIVSTMKSKFNA-SAAAGLDLVFQFNIEDGDN--HYLVVKDGTCEVVQGDAENPNVTLIMDSETLKGITSGETDGMQAF 81
Cdd:COG3255   1 DEWAEALCEKLNAaDAAAGWDGVVQFVITGEGGgaYYLVIDDGKCTVSEGDDDDADVTLTASYEDWKKLLTGELDPMTAF 80

                        90       100
                ....*....|....*....|..
gi 15597027  82 MAGKLRAEGDMMLAMKLGELFP 103
Cdd:COG3255  81 MTGKLKVEGDMGLAMKLMSLFK 102
 
Name Accession Description Interval E-value
SCP2 COG3255
Putative sterol carrier protein, contains SCP2 domain [Lipid transport and metabolism];
5-103 9.56e-34

Putative sterol carrier protein, contains SCP2 domain [Lipid transport and metabolism];


Pssm-ID: 442486 [Multi-domain]  Cd Length: 104  Bit Score: 112.31  E-value: 9.56e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597027   5 ADIVSTMKSKFNA-SAAAGLDLVFQFNIEDGDN--HYLVVKDGTCEVVQGDAENPNVTLIMDSETLKGITSGETDGMQAF 81
Cdd:COG3255   1 DEWAEALCEKLNAaDAAAGWDGVVQFVITGEGGgaYYLVIDDGKCTVSEGDDDDADVTLTASYEDWKKLLTGELDPMTAF 80

                        90       100
                ....*....|....*....|..
gi 15597027  82 MAGKLRAEGDMMLAMKLGELFP 103
Cdd:COG3255  81 MTGKLKVEGDMGLAMKLMSLFK 102
SCP2 pfam02036
SCP-2 sterol transfer family; This domain is involved in binding sterols. It is found in the ...
 26-102 1.51e-22

SCP-2 sterol transfer family; This domain is involved in binding sterols. It is found in the SCP2 protein as well as the C terminus of the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein contains an SPFH domain pfam01145.


Pssm-ID: 460423 [Multi-domain]  Cd Length: 100  Bit Score: 83.84  E-value: 1.51e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597027    26 VFQFNIEDGDNH-YLVVKDGTCEVVQGDAENPNVTLIMDSETLKGITSGETDGMQAFMAGKLRAEGDMMLAMKLGELF 102
Cdd:pfam02036  22 VIRFDLTDLGLSlTLDLKDGGGRVLAGDEGKADVTLSASDSDLLALATGKLNPQKAFMQGKLKIEGDMELAQKLEGLL 99
 
Name Accession Description Interval E-value
SCP2 COG3255
Putative sterol carrier protein, contains SCP2 domain [Lipid transport and metabolism];
5-103 9.56e-34

Putative sterol carrier protein, contains SCP2 domain [Lipid transport and metabolism];


Pssm-ID: 442486 [Multi-domain]  Cd Length: 104  Bit Score: 112.31  E-value: 9.56e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597027   5 ADIVSTMKSKFNA-SAAAGLDLVFQFNIEDGDN--HYLVVKDGTCEVVQGDAENPNVTLIMDSETLKGITSGETDGMQAF 81
Cdd:COG3255   1 DEWAEALCEKLNAaDAAAGWDGVVQFVITGEGGgaYYLVIDDGKCTVSEGDDDDADVTLTASYEDWKKLLTGELDPMTAF 80

                        90       100
                ....*....|....*....|..
gi 15597027  82 MAGKLRAEGDMMLAMKLGELFP 103
Cdd:COG3255  81 MTGKLKVEGDMGLAMKLMSLFK 102
SCP2 pfam02036
SCP-2 sterol transfer family; This domain is involved in binding sterols. It is found in the ...
 26-102 1.51e-22

SCP-2 sterol transfer family; This domain is involved in binding sterols. It is found in the SCP2 protein as well as the C terminus of the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein contains an SPFH domain pfam01145.


Pssm-ID: 460423 [Multi-domain]  Cd Length: 100  Bit Score: 83.84  E-value: 1.51e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597027    26 VFQFNIEDGDNH-YLVVKDGTCEVVQGDAENPNVTLIMDSETLKGITSGETDGMQAFMAGKLRAEGDMMLAMKLGELF 102
Cdd:pfam02036  22 VIRFDLTDLGLSlTLDLKDGGGRVLAGDEGKADVTLSASDSDLLALATGKLNPQKAFMQGKLKIEGDMELAQKLEGLL 99
Alkyl_sulf_C pfam14864
Alkyl sulfatase C-terminal; This domain is found at the C-terminus of alkyl sulfatases. ...
 16-102 4.31e-08

Alkyl sulfatase C-terminal; This domain is found at the C-terminus of alkyl sulfatases. Together with the N-terminal catalytic domain, this domain forms a hydrophobic chute and may recruit hydrophobic substrates.


Pssm-ID: 405542 [Multi-domain]  Cd Length: 124  Bit Score: 47.19  E-value: 4.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597027    16 NASAAAGLDLVFQFNIED-GDNHYLVVKDGTCEVVQG-DAENPNVTLIMDSETLKGITSGETDGMQAFMAGKLRAEGDmm 93
Cdd:pfam14864  24 DGPKAEGKDLTINLVFPDvDEQYRLTLSNGVLTYRKGrQADDADATLTLTRADLLALLLGKATLGKLIAAGKIKVEGD-- 101


                  ....*....
gi 15597027    94 lAMKLGELF 102
Cdd:pfam14864 102 -PSALAELL 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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