|
Name |
Accession |
Description |
Interval |
E-value |
| ARO8 |
COG1167 |
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ... |
18-469 |
1.29e-122 |
|
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis
Pssm-ID: 440781 [Multi-domain] Cd Length: 471 Bit Score: 366.08 E-value: 1.29e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 18 PEGPGLKYKRLAQGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFVRNRGRERARE 97
Cdd:COG1167 7 RDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPAPA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 98 AGFRNFVDSTEMCNDMSRNMHI-------PGNE---TELLSRSLQQLSAAPELlqELMLYTPDTGLLRHRQAGATWLSHG 167
Cdd:COG1167 87 PRAAAAVAAPALRRLLEAAPGVidlgsgaPDPDlfpLAALRRALRRALRRLPP--ALLGYGDPQGLPELREAIARYLARR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 168 EFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGLEMDEEGLLPDALEEACRTNRITA 247
Cdd:COG1167 165 GVPASPDQILITSGAQQALDLALRALLRPGDTVAVESPTYPGALAALRAAGLRLVPVPVDEDGLDLDALEAALRRHRPRA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 248 LYCTPTIQNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLM--AERPTPLCHL-LPERGILIGGMSKAVAAGLRVGY 324
Cdd:COG1167 245 VYVTPSHQNPTGATMSLERRRALLELARRHGVPIIEDDYDSELRydGRPPPPLAALdAPGRVIYIGSFSKTLAPGLRLGY 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 325 VHAPASMVSRMAAALRNSCWMATPLVLEIASRWVEDGTASALLEYQRGEIARRQALVVDLLQ-----GLTYRSHLCCPHF 399
Cdd:COG1167 325 LVAPGRLIERLARLKRATDLGTSPLTQLALAEFLESGHYDRHLRRLRREYRARRDLLLAALArhlpdGLRVTGPPGGLHL 404
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 400 WVEVPAPWRAIEIEQGMRGQQHLVTTAEAFSTGrGTLPQAIRISVSNSPggGNTLSDGFAVLAALLREGP 469
Cdd:COG1167 405 WLELPEGVDAEALAAAALARGILVAPGSAFSAD-GPPRNGLRLGFGAPS--EEELEEALRRLAELLRELA 471
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
136-448 |
1.39e-61 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 204.50 E-value: 1.39e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 136 AAPELLQELMLYTPDTGLLRHRQAGATWLS-HGEFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAA 214
Cdd:cd00609 21 AAAALRAGLLGYYPDPGLPELREAIAEWLGrRGGVDVPPEEIVVTNGAQEALSLLLRALLNPGDEVLVPDPTYPGYEAAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 215 QLLGIKVLGLEMDEEGLLPD--ALEEACRTNRITALY-CTPtiQNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLM 291
Cdd:cd00609 101 RLAGAEVVPVPLDEEGGFLLdlELLEAAKTPKTKLLYlNNP--NNPTGAVLSEEELEELAELAKKHGILIISDEAYAELV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 292 ---AERPTPLCHLLPERGILIGGMSKAVA-AGLRVGYVHAPASMV-SRMAAALRNSCWMATPLVLEIASRWVEDGTasAL 366
Cdd:cd00609 179 ydgEPPPALALLDAYERVIVLRSFSKTFGlPGLRIGYLIAPPEELlERLKKLLPYTTSGPSTLSQAAAAAALDDGE--EH 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 367 LEYQRGEIARRQALVVDLLQGLTYRSHL---CCPHFWVEVPAPWRAIEIEQGMRGQQHLVTTAEAFstgRGTLPQAIRIS 443
Cdd:cd00609 257 LEELRERYRRRRDALLEALKELGPLVVVkpsGGFFLWLDLPEGDDEEFLERLLLEAGVVVRPGSAF---GEGGEGFVRLS 333
|
....*
gi 15597296 444 VSNSP 448
Cdd:cd00609 334 FATPE 338
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
147-467 |
2.04e-33 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 129.87 E-value: 2.04e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLS-HGEFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGLE 225
Cdd:COG0436 63 YTPSAGIPELREAIAAYYKrRYGVDLDPDEILVTNGAKEALALALLALLNPGDEVLVPDPGYPSYRAAVRLAGGKPVPVP 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 226 MDEE-GLLPD--ALEEACrTNRITALY-CTPtiQNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLM--AERPTPLC 299
Cdd:COG0436 143 LDEEnGFLPDpeALEAAI-TPRTKAIVlNSP--NNPTGAVYSREELEALAELAREHDLLVISDEIYEELVydGAEHVSIL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 300 HL--LPERGILIGGMSKAVA-AGLRVGYVHAPASMVSRMAAALRNScWMATPLVLEIASRWVEDGTASALLEyQRGEIAR 376
Cdd:COG0436 220 SLpgLKDRTIVINSFSKSYAmTGWRIGYAVGPPELIAALLKLQSNL-TSCAPTPAQYAAAAALEGPQDYVEE-MRAEYRR 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 377 RQALVVDLLQ--GLTYRShlccPH----FWVEVPAPWR-AIEIEQGMRGQQH-LVTTAEAF-STGRGTlpqaIRISVSNS 447
Cdd:COG0436 298 RRDLLVEGLNeiGLSVVK----PEgafyLFADVPELGLdSEEFAERLLEEAGvAVVPGSAFgPAGEGY----VRISYATS 369
|
330 340
....*....|....*....|
gi 15597296 448 PgggNTLSDGFAVLAALLRE 467
Cdd:COG0436 370 E---ERLEEALERLARFLER 386
|
|
| PRK15481 |
PRK15481 |
transcriptional regulatory protein PtsJ; Provisional |
29-467 |
7.77e-25 |
|
transcriptional regulatory protein PtsJ; Provisional
Pssm-ID: 185378 [Multi-domain] Cd Length: 431 Bit Score: 106.28 E-value: 7.77e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 29 AQGIEESIRNGV----LRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFVRNRGRERAREAGfrnfv 104
Cdd:PRK15481 7 ANEIFDSIRQLIqagrLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSPSPVALEGG----- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 105 DSTEMCNDMSRnmhipGN-ETELL---SRSLQQLSAAPEllqelmLYTPDTGLLRHRQAGATWLSH---GEFQAEhqqil 177
Cdd:PRK15481 82 DPGTPLHDLAG-----GNpDPQRLpdlSRYFARLSRTPR------LYGDAPVSPELHAWAARWLRDdcpVAFEID----- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 178 CVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGLEMDEEGLLPDALEEACRtNRITALYCTPTIQNP 257
Cdd:PRK15481 146 LTSGAIDAIERLLCAHLLPGDSVAVEDPCFLSSINMLRYAGFSASPVSVDAEGMQPEKLERALA-QGARAVILTPRAHNP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 258 TTAVMSGARRKEIAKICREH-GLIVIEDETHAVLMAerpTPLCHLLPE---RGILIGGMSKAVAAGLRVGYVHAPASmvs 333
Cdd:PRK15481 225 TGCSLSARRAAALRNLLARYpQVLVIIDDHFALLSS---SPYHSVIPQttqRWALIRSVSKALGPDLRLAFVASDSA--- 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 334 rMAAALRnscwmatpLVLEIASRWV----EDGTASALL--EYQRgEIA--------RRQALVVDLLQ-GLTYRSHLCCPH 398
Cdd:PRK15481 299 -TSARLR--------LRLNSGTQWVshllQDLVYACLTdpEYQA-RLAqarlfyaqRRQKLARALQQyGIAIPSPGDGLN 368
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 399 FWVEVPAPWRAIEIEQGMRGQqhLVTTAEAFSTGRGTlpQAIRISVSnspgggnTLSDG-FAVLAALLRE 467
Cdd:PRK15481 369 LWLPLDTDSQATALTLAKSGW--LVREGEAFGVSAPS--HGLRITLS-------TLNDAeINRLAADLHQ 427
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
147-335 |
2.61e-21 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 95.58 E-value: 2.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLS--HGeFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVteqLSYPGLIS---AAQLLGIKV 221
Cdd:PRK05764 64 YTPAAGIPELREAIAAKLKrdNG-LDYDPSQVIVTTGAKQALYNAFMALLDPGDEVI---IPAPYWVSypeMVKLAGGVP 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 222 LGLEMDEEG---LLPDALEEAcRTNRITAL-YCTPTiqNPTTAVMSGARRKEIAKICREHGLIVIEDET--HAVLMAERP 295
Cdd:PRK05764 140 VFVPTGEENgfkLTVEQLEAA-ITPKTKALiLNSPS--NPTGAVYSPEELEAIADVAVEHDIWVLSDEIyeKLVYDGAEF 216
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 15597296 296 TPLCHLLPE---RGILIGGMSKAVA-AGLRVGYVHAPASMVSRM 335
Cdd:PRK05764 217 TSIASLSPElrdRTITVNGFSKAYAmTGWRLGYAAGPKELIKAM 260
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
136-446 |
1.50e-20 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 92.75 E-value: 1.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 136 AAPELL--QELMLYTPDTGLLRHRQAGATWLSHGE---FQAEhQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGL 210
Cdd:pfam00155 22 AEKDALagGTRNLYGPTDGHPELREALAKFLGRSPvlkLDRE-AAVVFGSGAGANIEALIFLLANPGDAILVPAPTYASY 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 211 ISAAQLLGIKVL---GLEMDEEGLLPDALEEACRTNRITALYCTPtiQNPTTAVMSGARRKEIAKICREHGLIVIEDETH 287
Cdd:pfam00155 101 IRIARLAGGEVVrypLYDSNDFHLDFDALEAALKEKPKVVLHTSP--HNPTGTVATLEELEKLLDLAKEHNILLLVDEAY 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 288 AVLM--AERPTPLCHLLPER--GILIGGMSKA-VAAGLRVGYVHAPASMVSRMAAALR--NSCWMATPLVLEIASRwvED 360
Cdd:pfam00155 179 AGFVfgSPDAVATRALLAEGpnLLVVGSFSKAfGLAGWRVGYILGNAAVISQLRKLARpfYSSTHLQAAAAAALSD--PL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 361 GTASALLEYQRGEIARRQALVVDL----LQGLTYRSHLccphFWVEVPAPWRAIEIEQGMRGQQHL-VTTAEAFstgrgT 435
Cdd:pfam00155 257 LVASELEEMRQRIKERRDYLRDGLqaagLSVLPSQAGF----FLLTGLDPETAKELAQVLLEEVGVyVTPGSSP-----G 327
|
330
....*....|.
gi 15597296 436 LPQAIRISVSN 446
Cdd:pfam00155 328 VPGWLRITVAG 338
|
|
| PRK07309 |
PRK07309 |
pyridoxal phosphate-dependent aminotransferase; |
147-335 |
6.14e-18 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235985 Cd Length: 391 Bit Score: 85.55 E-value: 6.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLS---HGEFQAEhQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLg 223
Cdd:PRK07309 63 YTGMAGLLELRQAAADFVKekyNLDYAPE-NEILVTIGATEALSASLTAILEPGDKVLLPAPAYPGYEPIVNLVGAEIV- 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 224 lEMDEEG----LLPDALEEACRTN--RITALYCT-PTiqNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVL--MAER 294
Cdd:PRK07309 141 -EIDTTEndfvLTPEMLEKAILEQgdKLKAVILNyPA--NPTGVTYSREQIKALADVLKKYDIFVISDEVYSELtyTGEP 217
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 15597296 295 PTPLCHLLPERGILIGGMSKAVA-AGLRVGYVHAPASMVSRM 335
Cdd:PRK07309 218 HVSIAEYLPDQTILINGLSKSHAmTGWRIGLIFAPAEFTAQL 259
|
|
| YhcF |
COG1725 |
DNA-binding transcriptional regulator YhcF, GntR family [Transcription]; |
25-97 |
7.68e-18 |
|
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
Pssm-ID: 441331 [Multi-domain] Cd Length: 114 Bit Score: 79.07 E-value: 7.68e-18
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597296 25 YKRLAQGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFVRNRGRERARE 97
Cdd:COG1725 12 YEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLEE 84
|
|
| PRK07682 |
PRK07682 |
aminotransferase; |
147-335 |
1.27e-17 |
|
aminotransferase;
Pssm-ID: 181082 [Multi-domain] Cd Length: 378 Bit Score: 84.40 E-value: 1.27e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLS---HGEFQAEHQQILCVNGSQhGLLVVLMAMLRAGD-TLVTEQ--LSYPGLISAAQLLGIK 220
Cdd:PRK07682 53 YTANAGLLELRQEIAKYLKkrfAVSYDPNDEIIVTVGASQ-ALDVAMRAIINPGDeVLIVEPsfVSYAPLVTLAGGVPVP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 221 VLGLEMDEEGLLPDALEEACrTNRITA-LYCTPTiqNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLMAERP-TPL 298
Cdd:PRK07682 132 VATTLENEFKVQPAQIEAAI-TAKTKAiLLCSPN--NPTGAVLNKSELEEIAVIVEKHDLIVLSDEIYAELTYDEAyTSF 208
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 15597296 299 CHL--LPERGILIGGMSKAVA-AGLRVGYVHAPASMVSRM 335
Cdd:PRK07682 209 ASIkgMRERTILISGFSKGFAmTGWRLGFIAAPVYFSEAM 248
|
|
| WHTH_GntR |
cd07377 |
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
24-88 |
3.50e-17 |
|
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.
Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 75.56 E-value: 3.50e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597296 24 KYKRLAQGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFVR 88
Cdd:cd07377 2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
|
|
| PRK07324 |
PRK07324 |
transaminase; Validated |
175-334 |
1.38e-16 |
|
transaminase; Validated
Pssm-ID: 235989 Cd Length: 373 Bit Score: 81.14 E-value: 1.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 175 QILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGLEMDEE-GLLPDA--LEEACRTNriTALYCT 251
Cdd:PRK07324 82 NILQTNGATGANFLVLYALVEPGDHVISVYPTYQQLYDIPESLGAEVDYWQLKEEnGWLPDLdeLRRLVRPN--TKLICI 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 252 PTIQNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLMAERPTPLCHLLPERGILIGGMSKAVA-AGLRVGYVHAPAS 330
Cdd:PRK07324 160 NNANNPTGALMDRAYLEEIVEIARSVDAYVLSDEVYRPLDEDGSTPSIADLYEKGISTNSMSKTYSlPGIRVGWIAANEE 239
|
....
gi 15597296 331 MVSR 334
Cdd:PRK07324 240 VIDI 243
|
|
| MngR |
COG2188 |
DNA-binding transcriptional regulator, GntR family [Transcription]; |
19-155 |
6.88e-16 |
|
DNA-binding transcriptional regulator, GntR family [Transcription];
Pssm-ID: 441791 [Multi-domain] Cd Length: 238 Bit Score: 76.82 E-value: 6.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 19 EGPGLKYKRLAQGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFVRNRGRERAREa 98
Cdd:COG2188 1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLS- 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 15597296 99 GFRNFVDstemcnDMSRNMHIPGneTELLSRSLQQlsaAPELLQELMLYTPDTGLLR 155
Cdd:COG2188 80 RLTSFTE------ELRARGREPS--TRVLSAERVP---ADEEVAEALGLPPGAPVLR 125
|
|
| HisC |
COG0079 |
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ... |
134-444 |
1.24e-15 |
|
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 439849 [Multi-domain] Cd Length: 341 Bit Score: 77.86 E-value: 1.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 134 LSAAPELLQELMLYtPDTGLLRHRQAGATWlshgeFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISA 213
Cdd:COG0079 32 LEAIAAALDALNRY-PDPDATALREALAEY-----YGVPPEQVLVGNGSDELIQLLARAFLGPGDEVLVPEPTFSEYPIA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 214 AQLLGIKVLGLEMDEE-GLLPDALEEACrTNRITALY-CTPTiqNPTTAVMSGARRKEIAKICREHGLIVIeDETHAVLM 291
Cdd:COG0079 106 ARAAGAEVVEVPLDEDfSLDLDALLAAI-TERTDLVFlCNPN--NPTGTLLPREELEALLEALPADGLVVV-DEAYAEFV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 292 AERPTpLCHLLPERG--ILIGGMSKAVA-AGLRVGYVHAPASMVSRMAAAlRNScWMATPLVLEIASRWVEDgtaSALLE 368
Cdd:COG0079 182 PEEDS-ALPLLARYPnlVVLRTFSKAYGlAGLRLGYAIASPELIAALRRV-RGP-WNVNSLAQAAALAALED---RAYLE 255
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597296 369 YQRGEIARRQALVVDLLQGL---TYRSHlcCPHFWVEVPAPwrAIEIEQGMRGQQHLVttaEAFSTGRgtLPQAIRISV 444
Cdd:COG0079 256 ETRARLRAERERLAAALRALgltVYPSQ--ANFVLVRVPED--AAELFEALLERGILV---RDFSSFG--LPDYLRITV 325
|
|
| PRK06348 |
PRK06348 |
pyridoxal phosphate-dependent aminotransferase; |
138-356 |
3.17e-15 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180537 Cd Length: 384 Bit Score: 77.07 E-value: 3.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 138 PELLQELMLYtpdtgllrhrqagatWLSHGEFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLL 217
Cdd:PRK06348 69 VELIEEIIKY---------------YSKNYDLSFKRNEIMATVGACHGMYLALQSILDPGDEVIIHEPYFTPYKDQIEMV 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 218 GIKVLGLE-MDEEGLL--PDALEEACrTNRITALYC-TPtiQNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLMAE 293
Cdd:PRK06348 134 GGKPIILEtYEEDGFQinVKKLEALI-TSKTKAIILnSP--NNPTGAVFSKETLEEIAKIAIEYDLFIISDEVYDGFSFY 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 294 RP-TPLCHL--LPERGILIGGMSKAVA-AGLRVGYVHAP-----------------ASMVSRMAA--ALRNSCWMATPLV 350
Cdd:PRK06348 211 EDfVPMATLagMPERTITFGSFSKDFAmTGWRIGYVIAPdyiietakiinegicfsAPTISQRAAiyALKHRDTIVPLIK 290
|
....*.
gi 15597296 351 LEIASR 356
Cdd:PRK06348 291 EEFQKR 296
|
|
| GntR |
pfam00392 |
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ... |
24-87 |
3.15e-12 |
|
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.
Pssm-ID: 306822 [Multi-domain] Cd Length: 64 Bit Score: 61.48 E-value: 3.15e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597296 24 KYKRLAQGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFV 87
Cdd:pfam00392 1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
|
|
| FadR |
COG2186 |
DNA-binding transcriptional regulator, FadR family [Transcription]; |
25-98 |
3.15e-12 |
|
DNA-binding transcriptional regulator, FadR family [Transcription];
Pssm-ID: 441789 [Multi-domain] Cd Length: 232 Bit Score: 66.11 E-value: 3.15e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597296 25 YKRLAQGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFVRNRGRERAREA 98
Cdd:COG2186 9 AEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDP 82
|
|
| PRK07550 |
PRK07550 |
aminotransferase; |
136-388 |
5.42e-12 |
|
aminotransferase;
Pssm-ID: 181026 [Multi-domain] Cd Length: 386 Bit Score: 67.29 E-value: 5.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 136 AAPELLQELM---------LYTPDTGLLRHRQAGATWLSH---GEFQAEhqQILCVNGSQHGLLVVLMAMLRAGDTLVTE 203
Cdd:PRK07550 43 PPPELLRALAeaaadpaahLYGPVEGLPELREAYAAHYSRlygAAISPE--QVHITSGCNQAFWAAMVTLAGAGDEVILP 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 204 QLSYPGLISAAQLLGIKVLGLEMDEE-GLLPDALE-EACRTNRITAL-YCTPTiqNPTTAVMSGARRKEIAKICREHGLI 280
Cdd:PRK07550 121 LPWYFNHKMWLDMLGIRPVYLPCDEGpGLLPDPAAaEALITPRTRAIaLVTPN--NPTGVVYPPELLHELYDLARRHGIA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 281 VIEDETHA--VLMAERPtplcH-LLPERG-----ILIGGMSKAVA-AGLRVGYVHAPASMVSRMAAALRNscwMA--TPL 349
Cdd:PRK07550 199 LILDETYRdfDSGGGAP----HdLFADPDwddtlVHLYSFSKSYAlTGHRVGAVVASPARIAEIEKFMDT---VAicAPR 271
|
250 260 270
....*....|....*....|....*....|....*....
gi 15597296 350 VLEIASRWVEDGTASALLEyQRGEIARRQALVVDLLQGL 388
Cdd:PRK07550 272 IGQIAVAWGLPNLADWRAG-NRAEIARRRDAFRAVFARL 309
|
|
| PRK07681 |
PRK07681 |
LL-diaminopimelate aminotransferase; |
151-434 |
8.99e-12 |
|
LL-diaminopimelate aminotransferase;
Pssm-ID: 181081 Cd Length: 399 Bit Score: 66.75 E-value: 8.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 151 TGLLRHRQAGATWL--SHGEFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGLEMDE 228
Cdd:PRK07681 69 SGIQEFHEAVTEYYnnTHNVILNADKEVLLLMGSQDGLVHLPMVYANPGDIILVPDPGYTAYETGIQMAGATSYYMPLKK 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 229 E-GLLPD--ALEEACRTNRITALYCTPTiqNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLMAERPTPLCHL-LP- 303
Cdd:PRK07681 149 EnDFLPDleLIPEEIADKAKMMILNFPG--NPVPAMAHEDFFKEVIAFAKKHNIIVVHDFAYAEFYFDGNKPISFLsVPg 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 304 --ERGILIGGMSKAVA-AGLRVGYVHAPASMVSRMAAALRNSCWMATPLVLEIASRWVEDGtaSALLEYQRGEIARRQAL 380
Cdd:PRK07681 227 akEVGVEINSLSKSYSlAGSRIGYMIGNEEIVRALTQFKSNTDYGVFLPIQKAACAALRNG--AAFCEKNRGIYQERRDT 304
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 15597296 381 VVDLLQ--GLTYRSHLCCPHFWVEVPAPWRAIE-IEQGMRGQQHLVTTAEAF-STGRG 434
Cdd:PRK07681 305 LVDGFRtfGWNVDKPAGSMFVWAEIPKGWTSLSfAYALMDRANVVVTPGHAFgPHGEG 362
|
|
| HTH_GNTR |
smart00345 |
helix_turn_helix gluconate operon transcriptional repressor; |
28-87 |
1.19e-11 |
|
helix_turn_helix gluconate operon transcriptional repressor;
Pssm-ID: 197669 [Multi-domain] Cd Length: 60 Bit Score: 59.90 E-value: 1.19e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 28 LAQGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFV 87
Cdd:smart00345 1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
|
|
| PRK06107 |
PRK06107 |
aspartate transaminase; |
147-336 |
4.48e-11 |
|
aspartate transaminase;
Pssm-ID: 180403 Cd Length: 402 Bit Score: 64.37 E-value: 4.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQA-GATWLSHGEFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQ---LSYPGLISAAQLLGIKVL 222
Cdd:PRK06107 66 YTLVNGTPALRKAiIAKLERRNGLHYADNEITVGGGAKQAIFLALMATLEAGDEVIIPApywVSYPDMVLANDGTPVIVA 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 223 GLEMDEEGLLPDALEEACRTNRITALYCTPTiqNPTTAVMSGARRKEIAKICREH-GLIVIEDET--HAVLMAERPTPLC 299
Cdd:PRK06107 146 CPEEQGFKLTPEALEAAITPRTRWLILNAPS--NPTGAVYSRAELRALADVLLRHpHVLVLTDDIydHIRFDDEPTPHLL 223
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 15597296 300 HLLPE---RGILIGGMSKAVA-AGLRVGYVHAPASMVSRMA 336
Cdd:PRK06107 224 AAAPElrdRVLVTNGVSKTYAmTGWRIGYAAGPADLIAAIN 264
|
|
| PRK08361 |
PRK08361 |
aspartate aminotransferase; Provisional |
147-335 |
4.81e-11 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 236248 [Multi-domain] Cd Length: 391 Bit Score: 64.51 E-value: 4.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWL-SHGEFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGLE 225
Cdd:PRK08361 66 YTPNAGIPELREAIAEYYkKFYGVDVDVDNVIVTAGAYEATYLAFESLLEEGDEVIIPDPAFVCYVEDAKIAEAKPIRIP 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 226 MDEEGLL---PDALEEAC--RTNRITALYctPtiQNPTTAVMSGARRKEIAKICREHGLIVIEDE--THAVLMAERPTPL 298
Cdd:PRK08361 146 LREENEFqpdPDELLELItkRTRMIVINY--P--NNPTGATLDKEVAKAIADIAEDYNIYILSDEpyEHFLYEGAKHYPM 221
|
170 180 190
....*....|....*....|....*....|....*...
gi 15597296 299 CHLLPERGILIGGMSKAVA-AGLRVGYVHAPASMVSRM 335
Cdd:PRK08361 222 IKYAPDNTILANSFSKTFAmTGWRLGFVIAPEQVIKDM 259
|
|
| hisC |
TIGR01141 |
histidinol-phosphate aminotransferase; Alternate names: histidinol-phosphate transaminase; ... |
131-361 |
1.00e-10 |
|
histidinol-phosphate aminotransferase; Alternate names: histidinol-phosphate transaminase; imidazole acetol-phosphate transaminase Histidinol-phosphate aminotransferase is a pyridoxal-phosphate dependent enzyme. [Amino acid biosynthesis, Histidine family]
Pssm-ID: 273467 Cd Length: 350 Bit Score: 63.06 E-value: 1.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 131 LQQLSAApelLQELMLYtPDTGLLRHRQAGATWLShgeFQAEhqQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGL 210
Cdd:TIGR01141 39 KEALRAE---LKKLHRY-PDPDPAELKQALADYYG---VDPE--QILLGNGSDEIIDLLIRAFLEPGDAVLVPPPTYSMY 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 211 ISAAQLLGIKVLGLEMDEEGLLPDALEEACRTNRITALY-CTPtiQNPTTAVMSgarRKEIAKIC---REHGLIVI---- 282
Cdd:TIGR01141 110 EISAKIHGAEVVKVPLDEDGQLDLEDILVAIDDKPKLVFlCSP--NNPTGNLFS---RGDIEAVLertPGDALVVVdeay 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 283 ----EDETHAVLMAERPtplcHLlpergILIGGMSKAVA-AGLRVGYVHAPASMVSRMA-----------------AALR 340
Cdd:TIGR01141 185 gefsGEPSTLPLLAEYP----NL-----IVLRTLSKAFGlAGLRIGYAIANAEIIDALNkvrapfnlsrlaqaaaiAALR 255
|
250 260
....*....|....*....|...
gi 15597296 341 NSCWMAtPLVLEIAS--RWVEDG 361
Cdd:TIGR01141 256 DDDFIE-ATVEEINAerERLYDG 277
|
|
| PRK07683 |
PRK07683 |
aminotransferase A; Validated |
147-335 |
1.31e-10 |
|
aminotransferase A; Validated
Pssm-ID: 236075 Cd Length: 387 Bit Score: 62.82 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLSHG---EFQAEhQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLG 223
Cdd:PRK07683 61 YTHNAGLLELRKAACNFVKDKydlHYSPE-SEIIVTIGASEAIDIAFRTILEPGTEVILPAPIYPGYEPIIRLCGAKPVF 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 224 LEMDEEG--LLPDALEEACRTNRITALYCTPTiqNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLMAERPtplcH- 300
Cdd:PRK07683 140 IDTRSTGfrLTAEALENAITEKTRCVVLPYPS--NPTGVTLSKEELQDIADVLKDKNIFVLSDEIYSELVYEQP----Ht 213
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 15597296 301 ------LLPERGILIGGMSKAVA-AGLRVGYVHAPASMVSRM 335
Cdd:PRK07683 214 siahfpEMREKTIVINGLSKSHSmTGWRIGFLFAPSYLAKHI 255
|
|
| PRK06108 |
PRK06108 |
pyridoxal phosphate-dependent aminotransferase; |
147-331 |
1.75e-10 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180404 Cd Length: 382 Bit Score: 62.65 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLS--HG-EFQAEHqqILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLG 223
Cdd:PRK06108 57 YTHNLGIPELREALARYVSrlHGvATPPER--IAVTSSGVQALMLAAQALVGPGDEVVAVTPLWPNLVAAPKILGARVVC 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 224 LEMDEEG----LLPDALEEACrTNRITAL-YCTPTiqNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLM--AERPT 296
Cdd:PRK06108 135 VPLDFGGggwtLDLDRLLAAI-TPRTRALfINSPN--NPTGWTASRDDLRAILAHCRRHGLWIVADEVYERLYyaPGGRA 211
|
170 180 190
....*....|....*....|....*....|....*....
gi 15597296 297 PLCHLLPERG---ILIGGMSKAVA-AGLRVGYVHAPASM 331
Cdd:PRK06108 212 PSFLDIAEPDdriIFVNSFSKNWAmTGWRLGWLVAPPAL 250
|
|
| PRK08363 |
PRK08363 |
alanine aminotransferase; Validated |
147-326 |
3.37e-10 |
|
alanine aminotransferase; Validated
Pssm-ID: 181402 Cd Length: 398 Bit Score: 61.75 E-value: 3.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGA----TWlshGEFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLL-GIKV 221
Cdd:PRK08363 66 YGPSEGLPELREAIVkrekRK---NGVDITPDDVRVTAAVTEALQLIFGALLDPGDEILIPGPSYPPYTGLVKFYgGVPV 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 222 LGLEMDEEGLLPDALEEACRTNRITALYCTPTIQNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLMAE----RPTP 297
Cdd:PRK08363 143 EYRTIEEEGWQPDIDDIRKKITEKTKAIAVINPNNPTGALYEKKTLKEILDIAGEHDLPVISDEIYDLMTYEgkhvSPGS 222
|
170 180 190
....*....|....*....|....*....|
gi 15597296 298 LCHLLPErgILIGGMSKA-VAAGLRVGYVH 326
Cdd:PRK08363 223 LTKDVPV--IVMNGLSKVyFATGWRLGYIY 250
|
|
| tyr_nico_aTase |
TIGR01265 |
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal ... |
147-325 |
2.92e-09 |
|
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley.
Pssm-ID: 188123 Cd Length: 403 Bit Score: 58.89 E-value: 2.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLSHG-EFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIkvlglE 225
Cdd:TIGR01265 69 YAPSVGALAAREAVAEYLSSDlPGKLTADDVVLTSGCSQAIEICIEALANPGANILVPRPGFPLYDTRAAFSGL-----E 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 226 MDEEGLLP--------DALEEACRTNRITALYCTPTiqNPTTAVMSGARRKEIAKICREHGLIVIEDET--HAVLMAERP 295
Cdd:TIGR01265 144 VRLYDLLPekdweidlDGLESLADEKTVAIVVINPS--NPCGSVFSRDHLQKIAEVAEKLGIPIIADEIygHMVFGDAPF 221
|
170 180 190
....*....|....*....|....*....|..
gi 15597296 296 TPLCHLLPERGIL-IGGMSKA-VAAGLRVGYV 325
Cdd:TIGR01265 222 IPMASFASIVPVLsLGGISKRwVVPGWRLGWI 253
|
|
| tyr_amTase_E |
TIGR01264 |
tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found ... |
147-325 |
4.42e-09 |
|
tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found in animals and Trypanosoma cruzi. It is the first enzyme of a pathway of tyrosine degradation via homogentisate. Several plant enzyme designated as probable tyrosine aminotransferases are very closely related to an experimentally demonstrated nicotianamine aminotransferase, an enzyme in a siderophore (iron uptake chelator) biosynthesis pathway. These plant sequences are excluded from the model seed and score between the trusted an noise cutoffs. [Energy metabolism, Amino acids and amines]
Pssm-ID: 273529 [Multi-domain] Cd Length: 401 Bit Score: 58.26 E-value: 4.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLSHGEFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKV-LGLE 225
Cdd:TIGR01264 69 YAPTVGALSAREAIASYYHNPDGPIEADDVVLCSGCSHAIEMCIAALANAGQNILVPRPGFPLYETLAESMGIEVkLYNL 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 226 MDEEGLLPDALEEACRTNRITALYCTPTIQNPTTAVMSGARRKEIAKICREHGLIVIEDETHA--VLMAERPTPLCHLLP 303
Cdd:TIGR01264 149 LPDKSWEIDLKQLESLIDEKTAALIVNNPSNPCGSVFSRQHLEEILAVAERQCLPIIADEIYGdmVFSGATFEPLASLSS 228
|
170 180
....*....|....*....|....
gi 15597296 304 ERGILI-GGMSKA-VAAGLRVGYV 325
Cdd:TIGR01264 229 TVPILScGGLAKRwLVPGWRLGWI 252
|
|
| PRK07568 |
PRK07568 |
pyridoxal phosphate-dependent aminotransferase; |
147-340 |
2.26e-08 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181036 Cd Length: 397 Bit Score: 56.01 E-value: 2.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLSHGEFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGLEM 226
Cdd:PRK07568 62 YSHSQGIPELREAFAKYYKKWGIDVEPDEILITNGGSEAILFAMMAICDPGDEILVPEPFYANYNGFATSAGVKIVPVTT 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 227 D-EEGL-LPDALE-EACRTNRITA-LYCTPTiqNPTTAVMSGARRKEIAKICREHGLIVIEDETHA--VLMAERPTPLCH 300
Cdd:PRK07568 142 KiEEGFhLPSKEEiEKLITPKTKAiLISNPG--NPTGVVYTKEELEMLAEIAKKHDLFLISDEVYRefVYDGLKYTSALS 219
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 15597296 301 L--LPERGILIGGMSKAVAA-GLRVGyvhapaSMVSR----MAAALR 340
Cdd:PRK07568 220 LegLEDRVIIIDSVSKRYSAcGARIG------CLISKnkelIAAAMK 260
|
|
| PRK05166 |
PRK05166 |
histidinol-phosphate transaminase; |
138-324 |
4.12e-08 |
|
histidinol-phosphate transaminase;
Pssm-ID: 179950 Cd Length: 371 Bit Score: 55.14 E-value: 4.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 138 PELLQELMLYtPDTGLLRHRQAGAtwlshGEFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLL 217
Cdd:PRK05166 59 ADIAELLRLY-PDPQGRALREAIA-----ARTGVPADRIILGNGSEDLIAVICRAVLRPGDRVVTLYPSFPLHEDYPTMM 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 218 GIKVLGLEMDEE-GLLPDALEEACRTNRITALYCTPTiqNPTTAVMSGARRKEIAKICREHGLIVIeDETHAVLMAERPT 296
Cdd:PRK05166 133 GARVERVTVTPDlGFDLDALCAAVARAPRMLMFSNPS--NPVGSWLTADQLARVLDATPPETLIVV-DEAYAEYAAGDDY 209
|
170 180 190
....*....|....*....|....*....|...
gi 15597296 297 P-LCHLLPERG---ILIGGMSKAVA-AGLRVGY 324
Cdd:PRK05166 210 PsALTLLKARGlpwIVLRTFSKAYGlAGLRVGY 242
|
|
| C_P_lyase_phnF |
TIGR02325 |
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ... |
25-90 |
9.10e-08 |
|
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]
Pssm-ID: 131378 [Multi-domain] Cd Length: 238 Bit Score: 52.86 E-value: 9.10e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597296 25 YKRLAQGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFVRNR 90
Cdd:TIGR02325 10 WRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAAR 75
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
233-338 |
9.67e-08 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 53.89 E-value: 9.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 233 PDALEEACrTNRITALYC-TPtiQNPTTAVMSGARRKEIAKICREHGLIVIEDET--HAVLMAERPTPLCHL--LPERGI 307
Cdd:PRK07777 149 LDALRAAV-TPRTRALIVnSP--HNPTGTVLTAAELAAIAELAVEHDLLVITDEVyeHLVFDGARHLPLATLpgMRERTV 225
|
90 100 110
....*....|....*....|....*....|..
gi 15597296 308 LIGGMSKAVAA-GLRVGYVHAPASMVSRMAAA 338
Cdd:PRK07777 226 TISSAAKTFNVtGWKIGWACGPAPLIAAVRAA 257
|
|
| PRK06225 |
PRK06225 |
pyridoxal phosphate-dependent aminotransferase; |
175-360 |
1.60e-07 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235749 [Multi-domain] Cd Length: 380 Bit Score: 53.22 E-value: 1.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 175 QILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGLEM-DEE---GLLPDALEEACRTNriTALYC 250
Cdd:PRK06225 85 EALITAGATESLYLVMRAFLSPGDNAVTPDPGYLIIDNFASRFGAEVIEVPIySEEcnyKLTPELVKENMDEN--TRLIY 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 251 TPTIQNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLmAERPTPLCHLLPERGILIGGMSKAVA-AGLRVGYVHAPA 329
Cdd:PRK06225 163 LIDPLNPLGSSYTEEEIKEFAEIARDNDAFLLHDCTYRDF-AREHTLAAEYAPEHTVTSYSFSKIFGmAGLRIGAVVATP 241
|
170 180 190
....*....|....*....|....*....|....*....
gi 15597296 330 SMVSRMAAALRNScwMATPLV--------LEIASRWVED 360
Cdd:PRK06225 242 DLIEVVKSIVIND--LGTNVIaqeaaiagLKVKDEWIDR 278
|
|
| AHBA_syn |
cd00616 |
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal ... |
176-289 |
2.50e-07 |
|
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.
Pssm-ID: 99740 [Multi-domain] Cd Length: 352 Bit Score: 52.54 E-value: 2.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 176 ILCVNGSqHGLLVVLMAM-LRAGDTLVTEQLSYPGLISAAQLLGIKVLGLEMDEEGLL--PDALEEAcrtnrITalyctp 252
Cdd:cd00616 37 VAVSSGT-AALHLALRALgIGPGDEVIVPSFTFVATANAILLLGATPVFVDIDPDTYNidPELIEAA-----IT------ 104
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 15597296 253 tiqNPTTAVM------SGARRKEIAKICREHGLIVIEDETHAV 289
Cdd:cd00616 105 ---PRTKAIIpvhlygNPADMDAIMAIAKRHGLPVIEDAAQAL 144
|
|
| DegT_DnrJ_EryC1 |
pfam01041 |
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all ... |
163-289 |
3.19e-07 |
|
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.
Pssm-ID: 395827 Cd Length: 360 Bit Score: 52.29 E-value: 3.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 163 WLSHGEFQAEHQQILC----------VNGSQHGLLVVLMAM-LRAGDTLVTEQLSYPGLISAAQLLGIKVLGLEMDEEGL 231
Cdd:pfam01041 19 WLTTGPYVREFERAFAaylgvkhaiaVSSGTAALHLALRALgVGPGDEVITPSFTFVATANAALRLGAKPVFVDIDPDTY 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597296 232 L--PDALEEAcrtnritalyctptIQNPTTAVMS------GARRKEIAKICREHGLIVIEDETHAV 289
Cdd:pfam01041 99 NidPEAIEAA--------------ITPRTKAIIPvhlygqPADMDAIRAIAARHGLPVIEDAAHAL 150
|
|
| PRK06207 |
PRK06207 |
pyridoxal phosphate-dependent aminotransferase; |
181-385 |
3.61e-07 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235742 Cd Length: 405 Bit Score: 52.07 E-value: 3.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 181 GSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGLEMDEE------GLLPDALEEACRTNRITALYCTPti 254
Cdd:PRK06207 110 GTQGALFLAVAATVARGDKVAIVQPDYFANRKLVEFFEGEMVPVQLDYLsadkraGLDLDQLEEAFKAGVRVFLFSNP-- 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 255 QNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLMAERpTPLCHLL-----PERGILIGGMSKAVA-AGLRVGYVHAP 328
Cdd:PRK06207 188 NNPAGVVYSAEEIAQIAALARRYGATVIVDQLYSRLLYDG-TSYTHLRalpidPENVITIMGPSKTESlSGYRLGVAFGS 266
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597296 329 ASMVSRM---------------AAALRNscWMATPlvleiaSRWVEDgtasalleyqrgEIARRQALVVDLL 385
Cdd:PRK06207 267 PAIIDRMeklqaivslraagysQAVLRT--WFSEP------DGWMKD------------RIARHQAIRDDLL 318
|
|
| PRK12414 |
PRK12414 |
putative aminotransferase; Provisional |
147-335 |
7.95e-07 |
|
putative aminotransferase; Provisional
Pssm-ID: 183514 Cd Length: 384 Bit Score: 50.94 E-value: 7.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGL--LRHRQAGATWLSHGEFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGL 224
Cdd:PRK12414 62 YAPMAGIaaLREALAEKTERLYGARYDPASEVTVIASASEGLYAAISALVHPGDEVIYFEPSFDSYAPIVRLQGATPVAI 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 225 EMDEEGLLPDALEEACRTNRITALYCTPTIQNPTTAVMSGARRKEIAKICREHGLIVIEDET--HAVL-------MAERP 295
Cdd:PRK12414 142 KLSPEDFRVNWDEVAAAITPRTRMIIVNTPHNPSATVFSAADLARLAQLTRNTDIVILSDEVyeHVVFdgarhhsMARHR 221
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 15597296 296 TplchlLPERGILIGGMSKAV-AAGLRVGYVHAPASMVSRM 335
Cdd:PRK12414 222 E-----LAERSVIVSSFGKSYhVTGWRVGYCLAPAELMDEI 257
|
|
| PRK10421 |
PRK10421 |
DNA-binding transcriptional repressor LldR; Provisional |
27-90 |
1.08e-06 |
|
DNA-binding transcriptional repressor LldR; Provisional
Pssm-ID: 236690 [Multi-domain] Cd Length: 253 Bit Score: 49.77 E-value: 1.08e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597296 27 RLAQGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFVRNR 90
Cdd:PRK10421 6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWR 69
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
169-326 |
1.87e-06 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 47.76 E-value: 1.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 169 FQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLG------IKVLGlemDEEGLLPDALEEACRT 242
Cdd:cd01494 13 LQPGNDKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSRYWVAAELAgakpvpVPVDD---AGYGGLDVAILEELKA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 243 NRITALYCTPTIQNPTTAVmsgARRKEIAKICREHGLIVIEDETHAVLmaERPTPLCHLLPER-GILIGGMSKAVAAGlR 321
Cdd:cd01494 90 KPNVALIVITPNTTSGGVL---VPLKEIRKIAKEYGILLLVDAASAGG--ASPAPGVLIPEGGaDVVTFSLHKNLGGE-G 163
|
....*
gi 15597296 322 VGYVH 326
Cdd:cd01494 164 GGVVI 168
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
189-286 |
2.62e-06 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 49.69 E-value: 2.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 189 VLMAMLRAGDTLVTEQLSY---PGLISAAQLLGIKVLGLEMDEegllPDALEEACRTNriTALYCTPTIQNPTTAVmsgA 265
Cdd:PRK05939 78 VFLTLLRAGDHLVSSQFLFgntNSLFGTLRGLGVEVTMVDATD----VQNVAAAIRPN--TRMVFVETIANPGTQV---A 148
|
90 100
....*....|....*....|.
gi 15597296 266 RRKEIAKICREHGLIVIEDET 286
Cdd:PRK05939 149 DLAGIGALCRERGLLYVVDNT 169
|
|
| PRK10225 |
PRK10225 |
Uxu operon transcriptional regulator; |
25-112 |
3.11e-06 |
|
Uxu operon transcriptional regulator;
Pssm-ID: 182318 [Multi-domain] Cd Length: 257 Bit Score: 48.48 E-value: 3.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 25 YKRLAQGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFVRNRGRERAREAGFRNFv 104
Cdd:PRK10225 11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTDSPDANV- 89
|
....*...
gi 15597296 105 dstemCND 112
Cdd:PRK10225 90 -----CND 92
|
|
| PRK05957 |
PRK05957 |
pyridoxal phosphate-dependent aminotransferase; |
171-328 |
3.24e-06 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235654 Cd Length: 389 Bit Score: 49.30 E-value: 3.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 171 AEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGLEMDEEGLL-PDALEEAcrtnrITAly 249
Cdd:PRK05957 87 NNEQAIVVTAGSNMAFMNAILAITDPGDEIILNTPYYFNHEMAITMAGCQPILVPTDDNYQLqPEAIEQA-----ITP-- 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 250 CTPTI-----QNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLMAERptpLCHLLPER-------GILIGGMSKAVA 317
Cdd:PRK05957 160 KTRAIvtispNNPTGVVYPEALLRAVNQICAEHGIYHISDEAYEYFTYDG---VKHFSPGSipgsgnhTISLYSLSKAYG 236
|
170
....*....|..
gi 15597296 318 -AGLRVGYVHAP 328
Cdd:PRK05957 237 fASWRIGYMVIP 248
|
|
| PRK08912 |
PRK08912 |
aminotransferase; |
147-338 |
3.48e-06 |
|
aminotransferase;
Pssm-ID: 181580 Cd Length: 387 Bit Score: 49.20 E-value: 3.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATwlSHGEFQA----EHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLG--IK 220
Cdd:PRK08912 59 YPPMMGLPELRQAVAA--HYARFQGldldPETEVMVTSGATEALAAALLALVEPGDEVVLFQPLYDAYLPLIRRAGgvPR 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 221 VLGLEMDEEGLLPDALEEAC--RTNRItaLYCTPtiQNPTTAVMSGARRKEIAKICREHGLIVIEDET--HAVLMAERPT 296
Cdd:PRK08912 137 LVRLEPPHWRLPRAALAAAFspRTKAV--LLNNP--LNPAGKVFPREELALLAEFCQRHDAVAICDEVweHVVFDGRRHI 212
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 15597296 297 PLCHL--LPERGILIGGMSKAVA-AGLRVGYVHAPASMVSRMAAA 338
Cdd:PRK08912 213 PLMTLpgMRERTVKIGSAGKIFSlTGWKVGFVCAAPPLLRVLAKA 257
|
|
| PRK11402 |
PRK11402 |
transcriptional regulator PhoB; |
25-107 |
3.65e-06 |
|
transcriptional regulator PhoB;
Pssm-ID: 183118 [Multi-domain] Cd Length: 241 Bit Score: 48.29 E-value: 3.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 25 YKRLAQGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFVRNRGRERAREA--GFRN 102
Cdd:PRK11402 11 YATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTvsGFTD 90
|
....*
gi 15597296 103 FVDST 107
Cdd:PRK11402 91 FGVSQ 95
|
|
| PRK07366 |
PRK07366 |
LL-diaminopimelate aminotransferase; |
89-340 |
1.08e-05 |
|
LL-diaminopimelate aminotransferase;
Pssm-ID: 180947 Cd Length: 388 Bit Score: 47.37 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 89 NRGRERAREAGfRNFVDSTEMCNDMSRNMHIpgneTELLSRSLQQLSAAPELLQElmlytpdtGLLRHRQAGATWLShGE 168
Cdd:PRK07366 19 DRAKAQARAAG-KELIDLSLGSSDLPAPAHA----LEAIAQSLHDPSTHGYLLFH--------GTLDFREAAAQWYE-QR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 169 FQAE---HQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGLEM-DEEGLLP---DALEEACR 241
Cdd:PRK07366 85 FGLAvdpETEVLPLIGSQEGTAHLPLAVLNPGDFALLLDPGYPSHAGGVYLAGGQIYPMPLrAENDFLPvfaDIPTEVLA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 242 TNRITAL-YctPtiQNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLMAERPTPLCHLL---PERGILIG--GMSKA 315
Cdd:PRK07366 165 QARLMVLsY--P--HNPTTAIAPLSFFQEAVAFCQQHDLVLVHDFPYVDLVFDGEVEPPSILqadPEKSVSIEffTLSKS 240
|
250 260
....*....|....*....|....*.
gi 15597296 316 V-AAGLRVGYVHAPASMVsrmaAALR 340
Cdd:PRK07366 241 YnMGGFRIGFAIGNAQLI----QALR 262
|
|
| pdhR |
PRK09464 |
pyruvate dehydrogenase complex transcriptional repressor PdhR; |
30-90 |
1.13e-05 |
|
pyruvate dehydrogenase complex transcriptional repressor PdhR;
Pssm-ID: 181879 [Multi-domain] Cd Length: 254 Bit Score: 46.94 E-value: 1.13e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597296 30 QGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFVRNR 90
Cdd:PRK09464 17 QQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSS 77
|
|
| PRK11523 |
PRK11523 |
transcriptional regulator ExuR; |
25-87 |
2.97e-05 |
|
transcriptional regulator ExuR;
Pssm-ID: 183176 [Multi-domain] Cd Length: 253 Bit Score: 45.61 E-value: 2.97e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597296 25 YKRLAQGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFV 87
Cdd:PRK11523 10 YQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
|
|
| PTZ00433 |
PTZ00433 |
tyrosine aminotransferase; Provisional |
147-325 |
3.63e-05 |
|
tyrosine aminotransferase; Provisional
Pssm-ID: 185613 Cd Length: 412 Bit Score: 45.93 E-value: 3.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATW----LSHGEFQAEHQQ----ILCvNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLG 218
Cdd:PTZ00433 71 YPPTVGSPEAREAVATYwrnsFVHKESLKSTIKkdnvVLC-SGVSHAILMALTALCDEGDNILVPAPGFPHYETVCKAYG 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 219 IKVLGLEMDEEGLLPDALEEACR--TNRITALyctpTIQNPTTAVMSGARRKEIAKI---CREHGLIVIEDETHAVL--- 290
Cdd:PTZ00433 150 IEMRFYNCRPEKDWEADLDEIRRlvDDRTKAL----IMTNPSNPCGSNFSRKHVEDIirlCEELRLPLISDEIYAGMvfn 225
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 15597296 291 ------MAERPTPLCHLlpergiLIGGMSKA-VAAGLRVGYV 325
Cdd:PTZ00433 226 gatftsVADFDTTVPRV------ILGGTAKNlVVPGWRLGWL 261
|
|
| PTZ00377 |
PTZ00377 |
alanine aminotransferase; Provisional |
147-285 |
6.93e-05 |
|
alanine aminotransferase; Provisional
Pssm-ID: 240391 [Multi-domain] Cd Length: 481 Bit Score: 45.34 E-value: 6.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLSH-GEFQAEHQQILCVNGSQHGLLVVLMAMLR-AGDTLVTEQLSYPgLISAA-QLLGIKVLG 223
Cdd:PTZ00377 111 YTDSAGYPFVRKAVAAFIERrDGVPKDPSDIFLTDGASSGIKLLLQLLIGdPSDGVMIPIPQYP-LYSAAiTLLGGKQVP 189
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597296 224 LEMDEE---GLLPDALEEA---CRTNRIT--ALYC-TPTiqNPTTAVMSGARRKEIAKICREHGLIVIEDE 285
Cdd:PTZ00377 190 YYLDEEkgwSLDQEELEEAyeqAVRNGITprALVViNPG--NPTGQVLTRDVMEEIIKFCYEKGIVLMADE 258
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
163-288 |
8.42e-05 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 44.67 E-value: 8.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 163 WLSHG----EFQAEHQQ-------ILCVNGSqHGLLVVLMAM-LRAGDTLVTEQLSYPGLISAAQLLGIKVLGLEMDEEG 230
Cdd:COG0399 25 WLTLGpevkEFEEEFAAylgvkhaVAVSSGT-AALHLALRALgIGPGDEVITPAFTFVATANAILYVGATPVFVDIDPDT 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597296 231 LL--PDALEEACrTNRITA-----LYCTPtiqnpttavmsgARRKEIAKICREHGLIVIEDETHA 288
Cdd:COG0399 104 YNidPEALEAAI-TPRTKAiipvhLYGQP------------ADMDAIMAIAKKHGLKVIEDAAQA 155
|
|
| PRK09764 |
PRK09764 |
GntR family transcriptional regulator; |
24-88 |
1.28e-04 |
|
GntR family transcriptional regulator;
Pssm-ID: 182065 [Multi-domain] Cd Length: 240 Bit Score: 43.28 E-value: 1.28e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597296 24 KYKRLAQGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFVR 88
Cdd:PRK09764 6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVK 70
|
|
| PLN00143 |
PLN00143 |
tyrosine/nicotianamine aminotransferase; Provisional |
147-291 |
1.31e-04 |
|
tyrosine/nicotianamine aminotransferase; Provisional
Pssm-ID: 165711 [Multi-domain] Cd Length: 409 Bit Score: 44.23 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLSHG-EFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGikvlgLE 225
Cdd:PLN00143 70 YAPTGGILPARRAIADYLSNDlPYQLSPDDVYLTLGCKHAAEIIIKVLARPEANILLPRPGFPDVETYAIFHH-----LE 144
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597296 226 MDEEGLLP--------DALEEACRTNRITALYCTPTiqNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLM 291
Cdd:PLN00143 145 IRHFDLLPekgwevdlDAVEAIADENTIAMVIINPG--NPCGSVYSYEHLNKIAETARKLGILVIADEVYGHIV 216
|
|
| PRK09276 |
PRK09276 |
LL-diaminopimelate aminotransferase; Provisional |
147-284 |
1.70e-04 |
|
LL-diaminopimelate aminotransferase; Provisional
Pssm-ID: 181749 Cd Length: 385 Bit Score: 43.75 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLShGEFQAE---HQQILCVNGSQHGLLVVLMAMLRAGD-TLVTEQlSYPGLISAAQLLGIKVL 222
Cdd:PRK09276 65 YPSYEGMLEFRKAVADWYK-RRFGVEldpETEVISLIGSKEGIAHIPLAFVNPGDvVLVPDP-GYPVYKIGTIFAGGEPY 142
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15597296 223 GLEMDEE-GLLPD--AL-EEACRTNRITAL-YctPtiQNPTTAVMSGARRKEIAKICREHGLIVIED 284
Cdd:PRK09276 143 FMPLKEEnGFLPDldAIpEDVAKKAKLMFInY--P--NNPTGAVADLEFFEEVVDFAKKYDIIVCHD 205
|
|
| PRK09265 |
PRK09265 |
aminotransferase AlaT; Validated |
256-325 |
1.93e-04 |
|
aminotransferase AlaT; Validated
Pssm-ID: 181738 Cd Length: 404 Bit Score: 43.65 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 256 NPTTAVMSGARRKEIAKICREHGLIVIEDE----------THAVLMAERPTPLChllpergILIGGMSKAV-AAGLRVGY 324
Cdd:PRK09265 179 NPTGAVYSKELLEEIVEIARQHNLIIFADEiydkilydgaVHISIASLAPDLLC-------VTFNGLSKAYrVAGFRVGW 251
|
.
gi 15597296 325 V 325
Cdd:PRK09265 252 M 252
|
|
| PRK09082 |
PRK09082 |
methionine aminotransferase; Validated |
147-331 |
2.65e-04 |
|
methionine aminotransferase; Validated
Pssm-ID: 181642 [Multi-domain] Cd Length: 386 Bit Score: 42.98 E-value: 2.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGA--TWLSHG-EFQAEHQqILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLG 223
Cdd:PRK09082 63 YPPMTGVAALREAIAakTARLYGrQYDADSE-ITVTAGATEALFAAILALVRPGDEVIVFDPSYDSYAPAIELAGGRAVR 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 224 LEMDEEGLLPDALEEACRTNRITALYCTPTIQNPTTAVMSGARRKEIAKICREHGLIVIEDET--HAVLMAERPTPLCH- 300
Cdd:PRK09082 142 VALQPPDFRVDWQRFAAAISPRTRLIILNTPHNPSGTVWSAADMRALWQLIAGTDIYVLSDEVyeHIVFDGAGHASVLRh 221
|
170 180 190
....*....|....*....|....*....|...
gi 15597296 301 -LLPERGILIGGMSKAV-AAGLRVGYVHAPASM 331
Cdd:PRK09082 222 pELRERAFVVSSFGKTYhVTGWKVGYCVAPAAL 254
|
|
| PRK03317 |
PRK03317 |
histidinol-phosphate aminotransferase; Provisional |
250-329 |
6.12e-04 |
|
histidinol-phosphate aminotransferase; Provisional
Pssm-ID: 235115 Cd Length: 368 Bit Score: 41.77 E-value: 6.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 250 CTPtiQNPTTAVMSGArrkEIAKICREHGLIVIEDETHAVLmAERPTP-LCHLLPERGILI--GGMSKAVA-AGLRVGY- 324
Cdd:PRK03317 167 TSP--NNPTGTALPLD---DVEAILDAAPGIVVVDEAYAEF-RRSGTPsALTLLPEYPRLVvsRTMSKAFAfAGGRLGYl 240
|
....*
gi 15597296 325 VHAPA 329
Cdd:PRK03317 241 AAAPA 245
|
|
| PRK08960 |
PRK08960 |
pyridoxal phosphate-dependent aminotransferase; |
147-391 |
7.16e-04 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181595 Cd Length: 387 Bit Score: 41.96 E-value: 7.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLS-HGEFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGLE 225
Cdd:PRK08960 65 YTAARGLPALREAIAGFYAqRYGVDVDPERILVTPGGSGALLLASSLLVDPGKHWLLADPGYPCNRHFLRLVEGAAQLVP 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 226 MDEEG---LLPDALEEACRTNRITALYCTPTiqNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLMAERPTPLCHLL 302
Cdd:PRK08960 145 VGPDSryqLTPALVERHWNADTVGALVASPA--NPTGTLLSRDELAALSQALRARGGHLVVDEIYHGLTYGVDAASVLEV 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 303 PERGILIGGMSKAVA-AGLRVGYVHAPASMVsRMAAALRNSCWMATPLVLEIASRWVEDGTASALLEYQRGEIARRQALV 381
Cdd:PRK08960 223 DDDAFVLNSFSKYFGmTGWRLGWLVAPPAAV-PELEKLAQNLYISASTPAQHAALACFEPETLAILEARRAEFARRRDFL 301
|
250
....*....|
gi 15597296 382 VDLLQGLTYR 391
Cdd:PRK08960 302 LPALRELGFG 311
|
|
| PRK06290 |
PRK06290 |
LL-diaminopimelate aminotransferase; |
181-431 |
7.43e-04 |
|
LL-diaminopimelate aminotransferase;
Pssm-ID: 235772 Cd Length: 410 Bit Score: 41.95 E-value: 7.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 181 GSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGLEMDEE-GLLPD--ALEEACRtNRITALYCT-PtiQN 256
Cdd:PRK06290 114 GSKPALAMLPSCFINPGDVTLMTVPGYPVTGTHTKYYGGEVYNLPLLEEnNFLPDldSIPKDIK-EKAKLLYLNyP--NN 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 257 PTTAVMSGARRKEIAKICREHGLIVIEDETHAVLMAERPtPLCHL-LP---ERGILIGGMSKAV-AAGLRVGYVHAPASM 331
Cdd:PRK06290 191 PTGAVATKEFYEEVVDFAKENNIIVVQDAAYAALTFDGK-PLSFLsVPgakEVGVEIHSLSKAYnMTGWRLAFVVGNELI 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 332 VSRMAAALRNScwmatplvleiAS---RWVEDGTASAL-----LEYQRGEIARRQALVVDLLQGLTYRSHLCCPHFWVEV 403
Cdd:PRK06290 270 VKAFATVKDNN-----------DSgqfIAIQKAGIYALdhpeiTEKIREKYSRRLDKLVKILNEVGFKAEMPGGTFYLYV 338
|
250 260
....*....|....*....|....*...
gi 15597296 404 PAPwraIEIEQGMRgqqhlVTTAEAFST 431
Cdd:PRK06290 339 KAP---KGTKSGIK-----FENAEEFSQ 358
|
|
| PRK13355 |
PRK13355 |
bifunctional HTH-domain containing protein/aminotransferase; Provisional |
186-324 |
1.00e-03 |
|
bifunctional HTH-domain containing protein/aminotransferase; Provisional
Pssm-ID: 237361 [Multi-domain] Cd Length: 517 Bit Score: 41.65 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 186 LLVVLM-AMLRAGDTLVTEQLSYPGLISAAQLLGIKVLGLEMDEEG-LLPDALE-EACRTNRITALYC-TPtiQNPTTAV 261
Cdd:PRK13355 220 LINLSMsALLDDGDEVLIPSPDYPLWTACVNLAGGTAVHYRCDEQSeWYPDIDDiRSKITSRTKAIVIiNP--NNPTGAL 297
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15597296 262 MSGARRKEIAKICREHGLIVIEDETHAVLMAE--RPTPLCHLLPERGIL-IGGMSKA-VAAGLRVGY 324
Cdd:PRK13355 298 YPREVLQQIVDIAREHQLIIFSDEIYDRLVMDglEHTSIASLAPDLFCVtFSGLSKShMIAGYRIGW 364
|
|
| PRK09990 |
PRK09990 |
DNA-binding transcriptional regulator GlcC; Provisional |
29-95 |
1.02e-03 |
|
DNA-binding transcriptional regulator GlcC; Provisional
Pssm-ID: 182186 [Multi-domain] Cd Length: 251 Bit Score: 40.91 E-value: 1.02e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15597296 29 AQGIEESIRNGVLRQGVKLPPHRILADKLGVTAGTVSRAYGELERMGLVEARVGDGTFVRNRGRERA 95
Cdd:PRK09990 13 AERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQD 79
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
185-295 |
1.02e-03 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 41.42 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 185 GLLVVLMAMLRAGDTLVTEQLSYPGLIS-AAQLL---GIKVLGLEMDEegllPDALEEACRTNriTALYCTPTIQNPTTA 260
Cdd:cd00614 67 AISTVLLALLKAGDHVVASDDLYGGTYRlFERLLpklGIEVTFVDPDD----PEALEAAIKPE--TKLVYVESPTNPTLK 140
|
90 100 110
....*....|....*....|....*....|....*
gi 15597296 261 VMSGARrkeIAKICREHGLIVIEDETHAVLMAERP 295
Cdd:cd00614 141 VVDIEA---IAELAHEHGALLVVDNTFATPYLQRP 172
|
|
| AGAT_like |
cd06451 |
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ... |
169-284 |
1.08e-03 |
|
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.
Pssm-ID: 99744 [Multi-domain] Cd Length: 356 Bit Score: 41.12 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 169 FQAEHQQILCVNGSQHGLL-VVLMAMLRAGDTLVTEQLSYPGLISA--AQLLGIKVLGLEMD-EEGLLPDALEEACRTNR 244
Cdd:cd06451 45 FQTENGLTFLLSGSGTGAMeAALSNLLEPGDKVLVGVNGVFGDRWAdmAERYGADVDVVEKPwGEAVSPEEIAEALEQHD 124
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 15597296 245 ITALYCTptiQNPT-TAVMSGArrKEIAKICREHGLIVIED 284
Cdd:cd06451 125 IKAVTLT---HNETsTGVLNPL--EGIGALAKKHDALLIVD 160
|
|
| PRK06836 |
PRK06836 |
pyridoxal phosphate-dependent aminotransferase; |
147-339 |
1.87e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180720 Cd Length: 394 Bit Score: 40.56 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLS--HG-EFQAEHqqILCVNGSQHGLLVVLMAMLRAGDTLVT------EQLSYpglISAAqll 217
Cdd:PRK06836 69 YMPNAGYPEVREAIAESLNrrFGtPLTADH--IVMTCGAAGALNVALKAILNPGDEVIVfapyfvEYRFY---VDNH--- 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 218 GIKVLGLEMDEEGLLPD--ALEEAcrtnrITA-----LYCTPtiQNPTTAVMSGARRKEIAKI----CREHG--LIVIED 284
Cdd:PRK06836 141 GGKLVVVPTDTDTFQPDldALEAA-----ITPktkavIINSP--NNPTGVVYSEETLKALAALleekSKEYGrpIYLISD 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 285 ETHAVLM---AERPTPLCHLlpERGILIGGMSKAVA-AGLRVGY--------------------------VHAPASMvSR 334
Cdd:PRK06836 214 EPYREIVydgAEVPYIFKYY--DNSIVVYSFSKSLSlPGERIGYiavnpemedaddlvaalvfanrilgfVNAPALM-QR 290
|
....*
gi 15597296 335 MAAAL 339
Cdd:PRK06836 291 VVAKC 295
|
|
| PRK08068 |
PRK08068 |
transaminase; Reviewed |
130-332 |
1.99e-03 |
|
transaminase; Reviewed
Pssm-ID: 181219 Cd Length: 389 Bit Score: 40.29 E-value: 1.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 130 SLQQLSAAPELLQelmlYTPDTGLLRHRQAGATWLSHgEFQAE---HQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLS 206
Cdd:PRK08068 53 ALQEAAENPANHK----YSPFRGYPFLKEAAADFYKR-EYGVTldpETEVAILFGGKAGLVELPQCLMNPGDTILVPDPG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 207 YPGLISAAQLLGIKVLGLEMDEE-GLLPD--ALEEACRtNRITALYCT-PtiQNPTTAVMSGARRKEIAKICREHGLIVI 282
Cdd:PRK08068 128 YPDYLSGVALARAQFETMPLIAEnNFLPDytKIPEEVA-EKAKLMYLNyP--NNPTGAVATKAFFEETVAFAKKHNIGVV 204
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 15597296 283 EDETHAVLMAERPTPLCHL----LPERGILIGGMSKAV-AAGLRVGYVHAPASMV 332
Cdd:PRK08068 205 HDFAYGAIGFDGQKPVSFLqtpgAKDVGIELYTLSKTFnMAGWRVAFAVGNESVI 259
|
|
| PLN02656 |
PLN02656 |
tyrosine transaminase |
147-290 |
2.18e-03 |
|
tyrosine transaminase
Pssm-ID: 178262 [Multi-domain] Cd Length: 409 Bit Score: 40.29 E-value: 2.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLSHG-EFQAEHQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPglisaAQLLGIKVLGLE 225
Cdd:PLN02656 69 YAPTVGLPQARRAIAEYLSRDlPYKLSLDDVFITSGCTQAIDVALSMLARPGANILLPRPGFP-----IYELCAAFRHLE 143
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597296 226 MDEEGLLP--------DALEEACRTNRITALYCTPTiqNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVL 290
Cdd:PLN02656 144 VRYVDLLPekgwevdlDAVEALADQNTVALVIINPG--NPCGNVYSYQHLKKIAETAEKLKILVIADEVYGHL 214
|
|
| PRK08175 |
PRK08175 |
aminotransferase; Validated |
147-288 |
2.68e-03 |
|
aminotransferase; Validated
Pssm-ID: 181268 [Multi-domain] Cd Length: 395 Bit Score: 40.08 E-value: 2.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLSHG---EFQAEHQQILCVnGSQHGLLVVLMAMLRAGDTLVTEQLSYPGLISAAQLLGIKVLG 223
Cdd:PRK08175 63 YSTSRGIPRLRRAISRWYQDRydvDIDPESEAIVTI-GSKEGLAHLMLATLDHGDTVLVPNPSYPIHIYGAVIAGAQVRS 141
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597296 224 LEMDEEGLLPDALEEACRTNritalYCTPTI------QNPTTAVMSGARRKEIAKICREHGLIVIEDETHA 288
Cdd:PRK08175 142 VPLVEGVDFFNELERAIRES-----YPKPKMmilgfpSNPTAQCVELEFFEKVVALAKRYDVLVVHDLAYA 207
|
|
| HTH_CRP |
cd00092 |
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ... |
50-90 |
2.97e-03 |
|
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.
Pssm-ID: 238044 [Multi-domain] Cd Length: 67 Bit Score: 36.10 E-value: 2.97e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 15597296 50 HRILADKLGVTAGTVSRAYGELERMGLVeARVGDGTFVRNR 90
Cdd:cd00092 28 RQEIADYLGLTRETVSRTLKELEEEGLI-SRRGRGKYRVNP 67
|
|
| PRK09148 |
PRK09148 |
LL-diaminopimelate aminotransferase; |
175-339 |
3.09e-03 |
|
LL-diaminopimelate aminotransferase;
Pssm-ID: 181674 [Multi-domain] Cd Length: 405 Bit Score: 39.66 E-value: 3.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 175 QILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYP----GLISAAQLlgIKVLGLEMDEEGLlpDALEEACRTN--RITAL 248
Cdd:PRK09148 94 QVVATLGSKEGFANMAQAITAPGDVILCPNPSYPihafGFIMAGGV--IRSVPAEPDEEFF--PALERAVRHSipKPIAL 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 249 -YCTPTiqNPTTAVMSGARRKEIAKICREHGLIVIEDETHA-VLMAERPTPLCHLLP---ERGILIGGMSKAVA-AGLRV 322
Cdd:PRK09148 170 iVNYPS--NPTAYVADLDFYKDVVAFAKKHDIIILSDLAYSeIYFDGNPPPSVLQVPgakDVTVEFTSMSKTFSmAGWRM 247
|
170
....*....|....*..
gi 15597296 323 GYvhapASMVSRMAAAL 339
Cdd:PRK09148 248 GF----AVGNERLIAAL 260
|
|
| PRK05942 |
PRK05942 |
aspartate aminotransferase; Provisional |
147-325 |
3.15e-03 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 180317 Cd Length: 394 Bit Score: 39.70 E-value: 3.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 147 YTPDTGLLRHRQAGATWLsHGEFQAE---HQQILCVNGSQHGLLVVLMAMLRAGDTLVTEQLSYPG-----LISAAQLLG 218
Cdd:PRK05942 69 YPPFEGTASFRQAITDWY-HRRYGVEldpDSEALPLLGSKEGLTHLALAYVNPGDVVLVPSPAYPAhfrgpLIAGAQIYP 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 219 IkVLGLEMDEEGLLPDALEEACRTNRItaLYCT-PTiqNPTTAVMSGARRKEIAKICREHGLIVIEDETHAVLMAE--RP 295
Cdd:PRK05942 148 I-ILKPENDWLIDLSSIPEEVAQQAKI--LYFNyPS--NPTTATAPREFFEEIVAFARKYEIMLVHDLCYAELAFDgyQP 222
|
170 180 190
....*....|....*....|....*....|...
gi 15597296 296 TPLCHL--LPERGILIGGMSKAV-AAGLRVGYV 325
Cdd:PRK05942 223 TSLLEIpgAKDIGVEFHTLSKTYnMAGWRVGFV 255
|
|
| MntR |
COG1321 |
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription]; |
53-97 |
3.77e-03 |
|
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
Pssm-ID: 440932 [Multi-domain] Cd Length: 135 Bit Score: 37.49 E-value: 3.77e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 15597296 53 LADKLGVTAGTVSRAYGELERMGLVEARVGDGTFVRNRGRERARE 97
Cdd:COG1321 30 IAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALR 74
|
|
| PRK06855 |
PRK06855 |
pyridoxal phosphate-dependent aminotransferase; |
256-314 |
3.98e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180734 Cd Length: 433 Bit Score: 39.55 E-value: 3.98e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597296 256 NPTTAVMSGARRKEIAKICREHGLIVIEDETHA--VLMAERPTPLCHLLPE-RGILIGGMSK 314
Cdd:PRK06855 182 NPTGAVYPKEILREIVDIAREYDLFIICDEIYNniVYNGKKTVPLSEVIGDvPGIALKGISK 243
|
|
| GLY1 |
COG2008 |
Threonine aldolase [Amino acid transport and metabolism]; |
187-281 |
7.93e-03 |
|
Threonine aldolase [Amino acid transport and metabolism];
Pssm-ID: 441611 [Multi-domain] Cd Length: 333 Bit Score: 38.51 E-value: 7.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597296 187 LVVLMAMLRAGDTLVTEQLSYpglI------SAAQLLGIKVLGLEmDEEGLL-PDALEEACRTNRI----TALYCtptIQ 255
Cdd:COG2008 64 QLALRAHTRPGDEVICHETAH---IyvdeggAPEALSGVKLLPVP-GEDGKLtPEDLEAAIRPGDVhfpqPGLVS---LE 136
|
90 100
....*....|....*....|....*...
gi 15597296 256 NPTT--AVMSGARRKEIAKICREHGLIV 281
Cdd:COG2008 137 NTTEggTVYPLEELRAIAAVAREHGLPL 164
|
|
| |
