|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
29-416 |
6.62e-163 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 463.70 E-value: 6.62e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 29 FWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFL 108
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 109 CGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEEAWRALF 188
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 189 MLGLLPALFVLVVRRLVKEPEIYREARQRNQ-GADKVSFYEIFAPGMLSITLRASLLTTGALGGYYAITAWLPTFLKTER 267
Cdd:cd17371 161 LLGALPALLVLFIRRFVKEPPQWQAARAARRhFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 268 GLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASGIFSGM 347
Cdd:cd17371 241 GLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGM 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597310 348 GSFLTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIGAFAAVSYGVVILAALSLPET 416
Cdd:cd17371 321 GAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
29-413 |
3.47e-60 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 199.36 E-value: 3.47e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 29 FWSCKIGYGLDGMDTQMLSFVIPTLIAL--WGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFT 106
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 107 FLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEEAWRA 186
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 187 LFMLGLLPALFVLVVRRlvkepeiyrearqrnqgadkvsfyeifapgmlsITLRASLLTTGALGGYYAITAWLPTFLKTE 266
Cdd:cd17316 161 LFLIGALPALLALLLRR---------------------------------RTLLLILLWFFISFGYYGLTTFLPTYLQTV 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 267 RGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQLPVSNGAMLWL-GFPLGFFASGIFS 345
Cdd:cd17316 208 LGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLlLFILSFFVGGVWG 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597310 346 GMGSFLTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLgqkLSLGLGIGAFAAVSYGVVILAALSL 413
Cdd:cd17316 288 ALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL---LASTGGTGVPALILALLAIVALIVA 352
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
27-385 |
7.69e-53 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 181.40 E-value: 7.69e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 27 RAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFT 106
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 107 FLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGwgltAILYSLMFSLLPPEEAWRA 186
Cdd:TIGR00895 97 LLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIG----AAVGGFLAGWLIPVFGWRS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 187 LFMLG-LLPALFVLVVRRLVKEPEIYREARQ---------------------------RNQGADKVSFYEIFAPGMLSIT 238
Cdd:TIGR00895 173 LFYVGgIAPLLLLLLLMRFLPESIDFLVSKRpetvrrivnaiapqmqaeaqsalpeqkSTQGTKRSVFKALFQGKTARIT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 239 LRASLLTTGALGGYYAITAWLPTFLKTERGLTVLGTsGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLL 318
Cdd:TIGR00895 253 VLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAA-TGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLV 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15597310 319 YTQLPVSNGaMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGML 385
Cdd:TIGR00895 332 GSTLFSPTL-LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-417 |
5.40e-50 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 173.13 E-value: 5.40e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 19 RALDKQERRAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLT 98
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 99 VLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLL 178
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 179 ppeeAWRALFMLGLLPALFVLVVRrlvkepeiyrearqrnqgadkvsfyeifapgmlsiTLRASLLTTGALGGYYAITAW 258
Cdd:COG2271 162 ----GWRAAFLILGLPGLLLALLR-----------------------------------FWLLALAYFLVYFALYGFLTW 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 259 LPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQLPVSNGAML-WLGFPLG 337
Cdd:COG2271 203 LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAiALLFLAG 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 338 FFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIGAFAAVSYGVVILAALSLPETR 417
Cdd:COG2271 283 FGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
16-414 |
3.45e-46 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 166.03 E-value: 3.45e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 16 GWYRALDKQERRAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTL 95
Cdd:PRK03893 9 PWYRHLNRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAM 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 96 QLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYslmf 175
Cdd:PRK03893 89 VISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVY---- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 176 SLLPPEEAWRALFMLGLLPALFVLVVRRLVKEPEIYREaRQRNQGADKVSFYEIFAPGMLSITLRASLLTTGAL------ 249
Cdd:PRK03893 165 SLVVPVWGWRALFFIGILPIIFALWLRKNLPEAEDWKE-KHAGKAPVRTMVDILYRGEHRIINILLTLAAAAALwfcfag 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 250 ----------------GGYYA-----------------------------ITAWLPTFLKTERGLTVLGTSGYLAMVILG 284
Cdd:PRK03893 244 nlqnaaivavlgllcaAIFISfmvqssgkrwptgvmlmvvvlfaflyswpIQALLPTYLKTDLGYDPHTVANVLFFSGFG 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 285 SYVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQLPVSNGAMLW-LGFPLGFFASGIFSGMGSFLTELFPTRIRGSG 363
Cdd:PRK03893 324 AAVGCCVGGFLGDWLGTRKAYVCSLLISQLLIIPVFAIGGANVWVLGlLLFFQQMLGQGISGLLPKLIGGYFDTEQRAAG 403
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 15597310 364 QGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIGAFA-AVSYGVVILAALSLP 414
Cdd:PRK03893 404 LGFTYNVGALGGALAPILGALIAQRLDLGTALASLSfSLTFVVILLIGLDMP 455
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
26-377 |
2.64e-38 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 141.26 E-value: 2.64e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 26 RRAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFF 105
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 106 TFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeeAWR 185
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----GWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 186 ALFMLGLLPALFVLVVRRLVkepeiYREARQRNQGADKVSFYEIFAPGMLsitLRASLLTTGALGGYYAITAWLPTFLKT 265
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRL-----LPESRPAARARLRGSLRELLRRPRL---LLLLLLAFLLGFGFFALFTYLPLYLQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 266 ERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQLPvSNGAMLWLGFPLGFFASGIFS 345
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-SLWLLLLALFLLGFGFGLLFP 315
|
330 340 350
....*....|....*....|....*....|..
gi 15597310 346 GMGSFLTELFPTRIRGSGQGFCYNAGRAIAAL 377
Cdd:COG2814 316 LLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
15-414 |
1.33e-36 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 138.52 E-value: 1.33e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 15 FGWYRALDKQERRAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLT 94
Cdd:PRK12307 6 FPWYSEITRPQKNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 95 LQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGwgltAILYSLM 174
Cdd:PRK12307 86 MMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIG----NIIAAYF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 175 FSLLPPEEAWRALFMLGLLPALFVLVVRRLVKEPEIYREARQRNQGADKVSFYEIFAPGMLSITLRASLLTT-------- 246
Cdd:PRK12307 162 MPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRAQFPLTlcvfivlf 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 247 GALGGYYAITAWLPTFLKTErGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQLPVSN 326
Cdd:PRK12307 242 SIFGANWPIFGLLPTYLAGE-GFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 327 GAMLWLG-FPLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLGqkLSLGLGIGAF---AAVS 402
Cdd:PRK12307 321 YLLLGAClFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLG--ITMGLGAALTfivAFWT 398
|
410
....*....|..
gi 15597310 403 YGVVILAALSLP 414
Cdd:PRK12307 399 ATILLIIGLSIP 410
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
38-413 |
3.92e-35 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 133.09 E-value: 3.92e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 38 LDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQ 117
Cdd:cd17365 10 LDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 118 LLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeeAWRALFMLGLLPALF 197
Cdd:cd17365 90 LALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAF----GWRSVFLLGGVPPLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 198 VLVvrrlvkepeiyrearqrnqgadkvsfyeifapgMLSITLRASLLTTGALGGYYAITAWLPTFLKtERGLTVLGTSGY 277
Cdd:cd17365 166 LLP---------------------------------LLRGTLLLWVTFFMGLLLVYLLNSWLPKLMV-EAGYSLSQALTI 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 278 LAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFPT 357
Cdd:cd17365 212 TLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPT 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 15597310 358 RIRGSGQGFCYNAGRAIAALFPMLIGMLgqkLSLGLGIGAFAAVSYGVVILAALSL 413
Cdd:cd17365 292 EVRATGVGWALGVGRLGAILGPLLGGLL---LAAGLGPESVFLALAIPAALGALAV 344
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
78-413 |
7.46e-31 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 122.25 E-value: 7.46e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 78 GGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQ--------LLVARTLMGFGFGGEWTAGAVLIGEVIKARDR 149
Cdd:cd17369 60 GGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQigilapilLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRR 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 150 GKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEE----AWRALFMLGLLPALFVLVVRRLVKEPEIYREARQRNQGAdKVS 225
Cdd:cd17369 140 GFYGSFPQLGAPVGLLLATGVFLLLSALLSDEAflswGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVV-RAP 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 226 FYEIFAPGMLSItLRASLLTTGALGGYYAITAWLPTFLKTERGLTvlgTSGYLAMVILGSYVG---YVVSAFLTDLIGRK 302
Cdd:cd17369 219 LVEVLRRHWRAL-LLAIGLRLAENVLFYLFTTFALSYATQTLGVD---RSTVLLAVLIASVVAaitIPLFGWLSDRVGRR 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 303 KNFVLFAVGS-FTVVLLYTQLPVSNGAMLWLGFPLGFFA--SGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAIAALFP 379
Cdd:cd17369 295 PVYLAGALLAaLFAFPFFWLLDTGSTWLIVLAAVVVLGVlhGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFA 374
|
330 340 350
....*....|....*....|....*....|....
gi 15597310 380 MLIGmlgqkLSLGLGIGAFAAVSYGVVILAALSL 413
Cdd:cd17369 375 PLIA-----TALVAATGSWWPVALYLAALAVISL 403
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
26-413 |
3.55e-30 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 119.99 E-value: 3.55e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 26 RRAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFF 105
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 106 TFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeeAWR 185
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF----GWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 186 -ALFMLGLLPALFVLVVRRLVKEPEIYREArqrnqgADKVSFYEIFAPGMLSITLRASLLTTGALGGYYAITAWLPTFLK 264
Cdd:COG2223 160 nAFLILGILLLVVAVLAWLFLRDPPAGAAA------AAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 265 TERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASGIF 344
Cdd:COG2223 234 DQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGN 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597310 345 SGMGSFLTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQKlslglgIGAFAAVSYGVVILAALSL 413
Cdd:COG2223 314 GAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA------TGSYTAAFLVFAVLALVAL 376
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-408 |
5.71e-27 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 110.98 E-value: 5.71e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 34 IGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQ 113
Cdd:cd06174 3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 114 NYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppEEAWRALFMLGLL 193
Cdd:cd06174 83 SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL--GFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 194 PALFVLVVRRLVKEPEIYREARQRNQGADKVSFYEIFAPGMLSITLRASLLTTGALGGYYAITAWLPTFLKTERGLTVLG 273
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 274 TSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTE 353
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15597310 354 LFPTRIRGSGQGFCYNAGRAIAALFPMLIGML---GQKLSLGLGIGAFAAVSYGVVIL 408
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlaaTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
38-411 |
1.58e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 109.59 E-value: 1.58e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 38 LDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQ 117
Cdd:cd17325 7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 118 LLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeeAWRALFMLGLLPALF 197
Cdd:cd17325 87 LLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL----GYRAPFLVCAALALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 198 VLVVR-RLVKEPEIYREARQRNQGADKVSFYEIFAPGMLSITLRASLLTTGALGGYYAItawLPTFLKTERGLTVLGTSG 276
Cdd:cd17325 163 ALVLAlLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPF---LPLYAAELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 277 YLAMVILGSYVGYVVSAFLTDLIGRKKNFVL-FAVGSFTVVLLYtqLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELF 355
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIgLLLSAVALLLLP--LATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15597310 356 PTRIRGSGQGF---CYNAGRAIAalfPMLIGMLGQKLSLGLGIGAFAAVSYGVVILAAL 411
Cdd:cd17325 318 PPEGRGTAMGLfntAFSLGMVLG---PLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
19-301 |
9.16e-26 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 106.05 E-value: 9.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 19 RALDKQERRAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLT 98
Cdd:COG0477 6 AAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 99 VLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLL 178
Cdd:COG0477 86 LLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 179 ppeeAWRALFMLGLLPALFVLVVRRLVKEPEIYREARQRNQGADKVSFYEIFAPGMLSITLRASLLTTGALGGYYAITAW 258
Cdd:COG0477 166 ----GWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLL 241
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 15597310 259 LPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGR 301
Cdd:COG0477 242 LLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLL 284
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
34-378 |
4.22e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 105.19 E-value: 4.22e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 34 IGYGLDGMDTQMLSFVIPTLIAL-WGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLA 112
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEdLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 113 QNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPpeeaWRALFMLGL 192
Cdd:pfam07690 83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG----WRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 193 LPALFVLVVRRLVKEPEiyREARQRNQGADKVSFYEIFAPGMLSITLRASLLTTGALGGYYAITAWLPTFLKTeRGLTVL 272
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPP--ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 273 GTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSF--TVVLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMGSF 350
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIlaALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315
|
330 340
....*....|....*....|....*...
gi 15597310 351 LTELFPTRIRGSGQGFcYNAGRAIAALF 378
Cdd:pfam07690 316 VSDLAPKEERGTASGL-YNTAGSLGGAL 342
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
26-420 |
1.10e-23 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 101.85 E-value: 1.10e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 26 RRAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFF 105
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 106 TFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKaRDRGKAVGLVQSGWAIGWGLTAILYSLMFsLLPPEEAWR 185
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLI-LLGLSLSWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 186 ALFMLGLLPALFVLVVRRLVKEPEIyrEARQRNQGADKVSFYEIFAPGMLSITLRASLLTTGALGgyyAITAWLPTFLKT 265
Cdd:COG0738 165 LPYLILAVLLLLLALLFLRSKLPEI--EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEG---AIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 266 ERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKnfVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPL-GFFASGIF 344
Cdd:COG0738 240 VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVR--LLRLSALLAAVGLLLALLAPGPWLALIGLALvGLGLSLMF 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597310 345 SGMGSFLTELFPTRiRGSGQGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIgAFAAVSYGVVILAALSLPETRGKQ 420
Cdd:COG0738 318 PTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAF-LVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
70-374 |
4.94e-23 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 100.06 E-value: 4.94e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 70 MTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQ--------LLVARTLMGFGFGGEWTAGAVLIG 141
Cdd:cd17367 48 VGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATigiwapiiLLLARLLQGLSVGGEYGTSATYLS 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 142 EVIKARDRGKAVGLvQSGWAIGWGLTAILYSL-MFSLLPPEE----AWRALFMLGLLPALFVLVVRRLVKEPEIYREARQ 216
Cdd:cd17367 128 EVAPPGRRGFYSSF-QYVTLIGGQLLALGVLLvLQHTLGEDQmaawGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 217 RNQgadkvsfyeiFAPGMLSITL---RASL----LTTGALGGYYAITAWLPTFLKTERGLTVLGTSGYLAMVILGSYVGY 289
Cdd:cd17367 207 SNE----------ASAGTLRELRrhpRELLlvvgLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQ 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 290 VVSAFLTDLIGRKKNFVLFAVGS--FTVVLLYTQLPVSNGAMLWLGFPLGF-FASGIFSGMGSFLTELFPTRIRGSGQGF 366
Cdd:cd17367 277 PLGGRLSDRIGRRPLLLFFGIGGtlATVPLLSALDHTDSPYTAFALVLVGLvFLSGYTSINAVVKAELFPTHVRALGVGL 356
|
....*...
gi 15597310 367 CYNAGRAI 374
Cdd:cd17367 357 PYALAVAI 364
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
38-412 |
6.76e-22 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 96.96 E-value: 6.76e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 38 LDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQ 117
Cdd:PRK11551 26 LEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 118 LLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGwgltAILYSLMFSLLPPEEAWRALFML-GLLPAL 196
Cdd:PRK11551 106 LLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFG----GALASVIGVLAAGDAAWRHIFYVgGVGPLL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 197 FVLVVRRLVKEPEIYREARQRNQGADKVsFYEIFAPGMLSITLRASLLTTGALGGYYAITAWLPTFLkTERGLTVLGTSG 276
Cdd:PRK11551 182 LVPLLMRWLPESRAFAQAAGAGKQRAPV-LRALFGEGRATATLLLWISYFFTLIVLYFLLNWLPSLL-VGQGLSRSQAGL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 277 YLAMVILGSYVGYVVSAFLTDLIGRKKnFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFP 356
Cdd:PRK11551 260 VQIAFNIGGALGSLLIGALMDRLRPRR-VVLLIYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYP 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 15597310 357 TRIRGSGQGFCYNAGRAIAALFPMLIGMLgqkLSLGLGIGAFAAVSYGVVILAALS 412
Cdd:PRK11551 339 TQVRGTGVGAAVAVGRLGSMAGPLLAGQL---LALGRSTVGVIGASIPVILVAALA 391
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
58-402 |
1.06e-20 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 93.00 E-value: 1.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 58 GIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGA 137
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 138 VLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeeAWRALFM-LGLLPALFVLVVRRLVkepeiyrEARQ 216
Cdd:cd17324 110 AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL----GWRAAFLaIAVLALLAALLLWRLL-------PSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 217 RNQGADKVSFYEIFAPGMLSITLRASLLTTGALGGYYAITAWLPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLT 296
Cdd:cd17324 179 PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 297 DLIGRKKNFVLFAVGSFTVVLLyTQLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFP-TRIRGSG-QGFCYNAGRAI 374
Cdd:cd17324 259 DRGGRRALLIALLLLAAALLLL-TLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPeARGLASSlYLAAYNLGGAL 337
|
330 340
....*....|....*....|....*...
gi 15597310 375 AALFPMLIGMLGQKLSLGLGIGAFAAVS 402
Cdd:cd17324 338 GAALGGLVLDHGGWAGVGWVGAALLLLA 365
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
78-422 |
1.21e-20 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 93.93 E-value: 1.21e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 78 GGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQ 157
Cdd:TIGR00898 143 GSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQ 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 158 SGWAIGwgltAILYSLMFSLLPPeeaWRALFMLGLLP--------------ALFVLVVRRLVKEPEIYREARQRN----- 218
Cdd:TIGR00898 223 VFFSLG----LVLLPLVAYFIPD---WRWLQLAVSLPtflffllswfvpesPRWLISQGRIEEALKILQRIAKINgkklp 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 219 QGADKVSFYE--------------IFAPGMLSITLRASLLTTGALGGYYAITAwlptflkterGLTVLGTSGYLAMVILG 284
Cdd:TIGR00898 296 AEVLSLSLEKdlssskkqysfldlFRTPNLRKTTLCLMMLWFTTAFSYYGLVL----------DLGNLGGNIYLDLFISG 365
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 285 --SYVGYVVSAFLTDLIGRKK----NFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFplgFFASGIFSGMGSFLTELFPTR 358
Cdd:TIGR00898 366 lvELPAKLITLLLIDRLGRRYtmaaSLLLAGVALLLLLFVPVDLYFLRTALAVLGK---FGITSAFQMVYLYTAELYPTV 442
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597310 359 IRGSGQGFCYNAGRaIAALFPMLIGMLGQKlSLGLGIGAFAAVSYgVVILAALSLPETRGKQLE 422
Cdd:TIGR00898 443 VRNLGVGVCSTMAR-VGSIISPFLVYLGEK-WLFLPLVLFGGLAL-LAGILTLFLPETKGVPLP 503
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
65-423 |
1.98e-20 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 92.72 E-value: 1.98e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 65 GFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLA---QNYEQLLVARTLMGFGFGGEWTAGAVLIG 141
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYIS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 142 EVIKARDRGKAVGLVQSGWAIGwGLTAILYSLMFSLLPPEEAWRALFMLGLLPALFVLVVRRLVKE-PEIYRE------- 213
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFG-ILLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPEsPRWLVEkgrleea 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 214 ----ARQRNQGADKVSFYEIFAPG--------------MLSITLRASLLTTGALG------GYYAITAWLPTFLKTergl 269
Cdd:pfam00083 208 revlAKLRGVPDVDRELDEIKDSLeagqeaekaswkelFSTKTRRQRLLIGVMLQifqqltGINAIFYYSTTIFEN---- 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 270 tvLGTSGYLAMVILGSYVGYV---VSAFLTDLIGRKKNFVLFAVG---------SFTVVLLYTQLPVSNGAMLWLGFPLG 337
Cdd:pfam00083 284 --LGLSDSFLVTIIVGVVNFVftfIAIFLVDRFGRRPLLLLGAAGmaicfvilgIVALLGVSKSDWAGIVAIVFIALFIA 361
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 338 FFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGR----AIAALFPMLIGMLGqklslGLGIGA-FAAVSYGVVILAALS 412
Cdd:pfam00083 362 FFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWlanfLIGFLFPIITDAIG-----LGYTFFiFAGLLVLFIIFVFFF 436
|
410
....*....|.
gi 15597310 413 LPETRGKQLEL 423
Cdd:pfam00083 437 VPETKGRTLEE 447
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
39-412 |
2.12e-20 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 91.83 E-value: 2.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 39 DGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQL 118
Cdd:cd17372 11 EAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 119 LVARTLMGFGFGGEwTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFsllpPEEAWRALFMLGLLPALFV 198
Cdd:cd17372 91 IILRCLVGLGLGGG-PQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVM----PRLGWRWLLAFSSVPSSLL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 199 LVvrrlvkepeIYREARQRNQGADKVSFYEIFAPGMLsITLRASLLTTGALGGYYAITAWLPTflKTERGLTVLGTSGYL 278
Cdd:cd17372 166 LV---------FYRWTPKTTLLLWVIWFGNAFAYYGV-VLLTTELNNSHNVCGSKSDSDSGES--PTEKQCRNSNDVDYR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 279 AMVI--LGSYVGYVVSAFLTDLIGRKKNFVLfAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFP 356
Cdd:cd17372 234 DVFIatFAEFPGLLISAAMIDRLGRKASMAS-MLFTCCIFLLLLLICQSPFILTVLLFGGRACISAAFTVVYIYTPEVYP 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 15597310 357 TRIRGSGQGFCYNAGRAIAALFPML-IGMLGQKLSLGLgigafaAVSYGVVILAALS 412
Cdd:cd17372 313 TAVRALGVGTGSSVGRIGAILCPFIaQVLVHGSQTIAL------LLFSVVCLVSAIC 363
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
35-416 |
6.69e-20 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 90.80 E-value: 6.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 35 GYGLDGMDTQMLSFVIPTLIALWGIG-----TGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLC 109
Cdd:cd17364 7 GFFTDAYDLFSISLVTKILGRLYYGGkgslpSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 110 GLAQNYE------QLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWaiGWGLTA------ILYSLMFSL 177
Cdd:cd17364 87 ALSPGSTplgvmgWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQ--GFGILAgaivtlILSAIFEHP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 178 LP------PEEAWRALFMLGLLPALFVLVVRRLVkepeiyrearqrnQGADKVSF-YEI--FAPGMLSITLRASLLTTGA 248
Cdd:cd17364 165 LPagtyhhADLVWRIVLGLGAIPALSVLYFRKHL-------------LGTAGTWFlLDIafYGQNLFQSTIISAIGFSKT 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 249 LGGYYAItawlptfLKTERGLTVLGTSGYLAmvilgsyvGYVVSAFLTDLIGRKK----NFVLFAVGSFTVVLLYTQLPV 324
Cdd:cd17364 232 MNAYQEL-------FNIAVGQLIIALAGTVP--------GYWFTVFLIDRIGRKKiqmmGFFGMTIFLLILAGPYDHWKI 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 325 SN-GAMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIGAFAAVSY 403
Cdd:cd17364 297 STiGFFVLYGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVAL 376
|
410
....*....|...
gi 15597310 404 GVVILAALSLPET 416
Cdd:cd17364 377 LGIILTLLFPEEK 389
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
39-414 |
7.41e-19 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 87.56 E-value: 7.41e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 39 DGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQL 118
Cdd:cd17441 11 DAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 119 LVARTLMGFGFGGEwTAGAVLIGEVIKARDRGKAVGLVQSGWAIGwgltAILYSLMFSLLPPEEAWRALFMLGLLPALFV 198
Cdd:cd17441 91 LVLRGLVGFGIGGV-PQSVTLYAEFLPMKSRAKCILLIEVFWALG----TVFEVLLAVFVMPTLGWRWLLILSALPLLIF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 199 LVVRRLVKEPEIYREArqrnqgadkVSFYEIFAPGMLS----ITLRASLLTTGALGGYYAITAWLPTFLKTERGLTvlgT 274
Cdd:cd17441 166 AVLCFWLPESARYWTT---------ILLWFIWFSNAFSyyglVLLTTELFQAGDVCSGSSGKKVEGKCSLECEYLT---T 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 275 SGY--LAMVILGSYVGYVVSAFLTDLIGRKKNFVL-FAVGSFTVVLLYtqLPVSNGAMLWLGFPLGFFASGIFSGMGSFL 351
Cdd:cd17441 234 SDYmdLLWTTLSEFPGLLVTLWIIDRFGRKKTMALcFFVFSFCTLLLF--SCVGRFSLTVLLFIARAFISGGFQAAYVYT 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597310 352 TELFPTRIRGSGQGFCYNAGRAIAALFPMLIG-MLGQKLSLGLGIGAFAAVsygVVILAALSLP 414
Cdd:cd17441 312 PEVYPTATRALGLGTCSGMARVGALITPFIAQvMLESSVYLTLSVYSGCCL---LAAIASCFLP 372
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
46-385 |
2.86e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 86.08 E-value: 2.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 46 LSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLM 125
Cdd:COG2807 37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 126 GFGFGgewtAGAVLIGEVIKaRDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEEAWRALFMLGLLPALFVLVVRRLV 205
Cdd:COG2807 117 GAGIA----VGNVLLPGLIK-RWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 206 kepeIYREARQRNQGADKVSFYEIFApgmLSITLRASLLTTGALGGYYAITAWLPTFLkTERGLTVLGTSGYLAMVILGS 285
Cdd:COG2807 192 ----LRRRPAAAAAAPAAASLRSLWR---SPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 286 YVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFpLGFFASGIFSGMGSFLTELFPT-RIRGSGQ 364
Cdd:COG2807 264 IPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVL-LGLGQGGLFPLALTLIGLRARTpAEAAALS 342
|
330 340
....*....|....*....|.
gi 15597310 365 GFCYNAGRAIAALFPMLIGML 385
Cdd:COG2807 343 GMAQSVGYLLAALGPLLVGAL 363
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
34-409 |
7.51e-18 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 84.16 E-value: 7.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 34 IGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQ 113
Cdd:cd17319 10 LAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 114 NYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeeAWRALFML-GL 192
Cdd:cd17319 90 SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF----GWRWAFIIeGL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 193 LPALFVLVVRRLVkepeiyrearqrnqgadkvsfyeifaPGMLSITlrasLLTTGALGGYYAITAWLPTFLKTERGLTVL 272
Cdd:cd17319 166 LGLLLAVLWWFYL--------------------------RQVWGLA----LGYFGINYALYGLLTWLPTYLKQARGFSLK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 273 GTSGYLAMVILGSYVGYVVSAFLTD-LIGRKKNFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMG-SF 350
Cdd:cd17319 216 QVGLLAAIPFLAGAIGMILGGRLSDrLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFwSL 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597310 351 LTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQKL---SLGLGIGAFAAVSYGVVILA 409
Cdd:cd17319 296 PADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATgsyTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
38-415 |
2.56e-17 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 83.00 E-value: 2.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 38 LDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQ 117
Cdd:cd17359 12 LFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 118 LLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQ----SGWAIGWGLTAILYSLMFSLLPPEEAWRALFMLGLL 193
Cdd:cd17359 92 FIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQlmivFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 194 PALFVLVVrrLVKEPEIYREARQRNQGAdkvsfyeIFAPGMLSITLRASllttgalgGYYAITAWLPTFLKTergLTVLG 273
Cdd:cd17359 172 PAILFLLG--MLFIPESPRWLVSKGKPI-------LIIGIGLAIFQQFV--------GINVIFYYGPEIFQN---AGFSE 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 274 TSGYLAMVILG--SYVGYVVSAFLTDLIGRKKNFVLFAVGSFT------VVLLYTQLPVSNGAMLWLGFPL--GFFASGI 343
Cdd:cd17359 232 NAALLQTIGIGvvNVIFTIIAILLVDKVGRKPLLLIGSIGMAIsllligTAFYFAPGSQASGIVALVLILLfvAFFAMSW 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597310 344 FSGMGSFLTELFPTRIRGSGQGFC----YNAGRAIAALFPMLIGMLGQKLSLGLgigaFAAVSYGVVILAALSLPE 415
Cdd:cd17359 312 GPVTWVLLSEIFPNRIRGLAMGIAvfflWIANFLVSLTFPILLAAFGLAFTFLI----FAVICVLAFLFVWKFVPE 383
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
63-422 |
6.05e-17 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 82.24 E-value: 6.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 63 EAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGE 142
Cdd:cd17358 42 QFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 143 VIKARDRGKAVGLVQSGWAIGwgltaILYSLMFSLLPPeeaWRALFMLGLLPALFVLVV--------RRLVK-------- 206
Cdd:cd17358 122 IAPKNVRGALGSLNQLLVNIG-----ILLGYVLGSFLP---WRTLALIGAIPPVVFLILlffipespRWLAKkgreeeae 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 207 ----------------EPEIYREARQRNQGADKVSFYEIFAPGMLSITLRASLLTTGA-LGGYYAITAWLPTFLKTergl 269
Cdd:cd17358 194 kslqflrgkdadiskeAAEIQEELAELEKEAKESSFSDLFQRKYLKPLVIGLGLMLFQqLSGINAVIFYASSIFDE---- 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 270 TVLGTSGYLAMVILGS--YVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVL---LYTQLPVSNGAMLWLG-FPLGFFASGI 343
Cdd:cd17358 270 AGSGLDPNTATIIIGVvqVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLalgLYFYLQEHGALLSSVSwLPLVGLVIYI 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 344 FS---GMGSF----LTELFPTRIRGSGQG----FCYNAGRAIAALFPMLIGMLGQKLSLGLgigaFAAVSYGVVILAALS 412
Cdd:cd17358 350 ISfsiGLGPLpwviMSEIFPAKIKGLAGSlvtlVNWLFAFIVTKTFPFLTLAWGASGTFWI----FAGICGLALVFVLLF 425
|
410
....*....|
gi 15597310 413 LPETRGKQLE 422
Cdd:cd17358 426 VPETKGKSLE 435
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
78-382 |
9.04e-17 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 81.25 E-value: 9.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 78 GGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQ--------LLVARTLMGFGFGGEWTAGAVLIGEVIKARDR 149
Cdd:cd17366 56 GGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTYATigvwapilLLLARMVQGFSTGGEYGGAATFVAEYAPDRKR 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 150 GKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEE----AWRALFMLGLLPALFVLVVRRlvkepeiyrearqrnqgadkvs 225
Cdd:cd17366 136 GFLGSWLEFGTLAGFILGAGLVTLLTLLLTEAQmldwGWRIPFLIAAPLGLVGLYLRR---------------------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 226 fyeifaPGMLSITLRASLLTTgalggYYAITAWLPTFLKTERGLTvlGTSGyLAMVILGSYVGYVVSAF---LTDLIGRK 302
Cdd:cd17366 194 ------PLLICIGLVLVFNVT-----NYMLLSYMPSYLEETLGYS--ETHG-LLVIIIIMVTMLVLQPFlgrLSDRVGRK 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 303 KnFVLFAVGSFTVVLLYTQLPVSNG-------AMLWLGFPLGFFAsgifSGMGSFLTELFPTRIRGSGQGFCYNAGRAIA 375
Cdd:cd17366 260 P-VYAAGLAGLLVLAVPAFLLMNSGsiaaifiGLLVLGLLLSCYT----ATMASTLPALFPTHVRYSALAIAFNISVSLF 334
|
....*..
gi 15597310 376 ALFPMLI 382
Cdd:cd17366 335 GGTTPLV 341
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
65-422 |
1.11e-16 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 81.14 E-value: 1.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 65 GFIHTMTLLASAAGGWIAGILSDRIGRVLTLQL-TVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEV 143
Cdd:cd17356 48 GLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIgCVIYIIGAIIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 144 IKARDRGKAVGLVQSGWAIGwGLTAILYSLMFSLLPPEEAWRALFMLGLLPALFVLVVRRLVkePEIYRearqrnqgadk 223
Cdd:cd17356 128 APKHIRGTLVSLYQLAITIG-ILVAYCINYGTHKLDGSAQWRIPLGLQIVWGLLLLIGMFFL--PESPR----------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 224 vsFYEIFAPGMLSITLrasllttGALGGYYAITAWLPTFLKterGLTVLGTSGYLAMVILGSY--VGYVVSAFLTDLIGR 301
Cdd:cd17356 194 --WLYRTILGIMLQLF-------QQLTGINYFFYYGTTIFQ---STGLTGSSPLLTSIILYIVnfVSTIPGLFFVDKFGR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 302 KKNFV---------LFAVGSFTVVLLYTQLP-------VSNGAMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSGQG 365
Cdd:cd17356 262 RTCLLigaagmsicLFIYAAVGVRYLIPNPQsgtsnksAGNGMIVFICLFIFSFATTWGPIAWVYVAEVFPLRVRSKGMA 341
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597310 366 FCYNA----GRAIAALFPMLIGMLGQKLSLglgigAFAAVSYGVVILAALSLPETRGKQLE 422
Cdd:cd17356 342 LATAFnwlwNFLISFFTPFIIGSIGFKYYY-----IFAGCNLLAFIVVFFFVPETKGLTLE 397
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
41-411 |
1.87e-16 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 80.31 E-value: 1.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 41 MDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLV 120
Cdd:cd17474 13 LGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 121 ARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLlppeeAWRALFML-GLLPALFVL 199
Cdd:cd17474 93 GRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-----SWRYPFFLlAALIPVAFL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 200 VVRRLVKEPEiyrearqrnqgADKVSFYEIFAPGMLSITLRASLLTTGALG-----GYYAITAWLPTFLKTERGLTVLGT 274
Cdd:cd17474 168 AILFLLPEPK-----------EKAKSSSATKLRDLKKALRGRGLLTFLVSAflyffLYFAFLTYLPFLLELLYGISPIII 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 275 ----SGYLAMVILGSY-VGYVVSAFLTDLIGRKKNFVLFAVgSFTVVLLYTQLPVSNGAMLWLGFPLGFFasgiFSGMGS 349
Cdd:cd17474 237 gllfAGWSVLLALGSLfVGRLLKKRFGARRILVIGLLLYAL-SLLLLGFVPSLALLLIAIVLFGLGLGLN----LPLLTT 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597310 350 FLTELFPTRIRGSGQGFcYNAGRAI-AALFPMLIGMLGQKLSL-GLGIGAFAAVSYGVVILAAL 411
Cdd:cd17474 312 LVTELAPEEERGTASSL-YNFVRFLgQAVGPLLFGLLLEIFGLsAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
78-416 |
2.61e-15 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 77.03 E-value: 2.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 78 GGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQ--------LLVARTLMGFGFGGEWTAGAVLIGEVIKARDR 149
Cdd:cd17368 56 GAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATigiaapllVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRR 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 150 GKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEE----AWRALFMLGLLPALFVLVVRRLVKEPEIYREarqRNQGADKVS 225
Cdd:cd17368 136 GFYTSWQSASQQVAIVAGALVGYLLSLTLTAEAlaewGWRIPFFIGLLIIPLGLWLRRSLEETEAFLE---RKARPTRRE 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 226 FYEIFAPGMLSITLrASLLTTGALGGYYAITAWLPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNF 305
Cdd:cd17368 213 LFALLANNRRIILL-GMLLVAGSTVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 306 VLFAVGSFTVVLLYTQLPV---SNGAMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAIAALFPM-- 380
Cdd:cd17368 292 LVITLAALVTLYPVFAWLTaapSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQfi 371
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15597310 381 ---LIGMLGQKLSLG--LGIGAFAAvsygvvILAALSLPET 416
Cdd:cd17368 372 vtwLIELTGSPLAPAwyLMGAALLG------LLATLMLRET 406
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
45-413 |
4.80e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 76.06 E-value: 4.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 45 MLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTL 124
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 125 MGFGFGGEWTAGAVLIGEVIKARdRGKAVGLVQSGWAIGWGLTAILYSLMFSLLpPEEAWRALFMLGLLPALFVLVVRRL 204
Cdd:cd17478 94 AGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALF-GGLGLLILLIIPGLAVALLLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 205 VKEPEIYREARQRNQGADKVSFYEIFAPGMLSITLRASLlttgalggYYAITAWLPTFLkTERGLTVLGTSGYLAMVILG 284
Cdd:cd17478 172 LKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWV--------LSSLTTFLPFYL-VQRGYSLVFAGLLLSLFLFA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 285 SYVGYVVSAFLTDLIGRKKnfvLFAVGSFTVVLLYTQLPVSNGAMLWLGFPL-GFFASGIFSGMGSFLTELFPTRIrGSG 363
Cdd:cd17478 243 GAIGTLIGGPLSDRFGRRR---VIIASLLLAAPFLLLFLLTPGIWSYILLVLaGFLLFASFPVTVVLAQELLPGNV-GLA 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 15597310 364 QGFCYNAGRAIAALFPMLIGMLGQKLSLGLgigAFAAVSYGVVILAALSL 413
Cdd:cd17478 319 SGLMMGLSFGLGGIGAPVLGALADAFGLES---VLLILALLPLLGALLAF 365
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
34-341 |
7.39e-15 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 75.74 E-value: 7.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 34 IGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQ 113
Cdd:cd17328 6 LINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 114 NYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPeeaWR-ALFMLGL 192
Cdd:cd17328 86 NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGG---WRwAFRVTGV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 193 LPALFVLVVRRLVKEPEIYREARQRNQGADKVSFYEIFA-----PGMLSITLRASLLTTGAlggyYAITAWLPTFLKteR 267
Cdd:cd17328 163 LGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKalaknPSFILSTLGFTAVSFVT----GALAFWAPTFFL--R 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 268 GLTVLGTSGYLAMVILGS------YVGYVVSAFLTDLIGRKKN--------FVLFAVGSFTVVLLYtqLPVSNGAMLW-L 332
Cdd:cd17328 237 AFGVGDLSSADVGLIFGAitciagVLGVLLGGILADRLRRKTPradplvcaVGLLAAAPFLFLALV--LALSNLLLAWvL 314
|
....*....
gi 15597310 333 GFPLGFFAS 341
Cdd:cd17328 315 LFLGEFLLS 323
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
61-367 |
1.30e-14 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 74.53 E-value: 1.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 61 TGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLI 140
Cdd:cd17315 33 TSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 141 GEVIKARDRGKAVGLVQSGWAIGwgltaILYSLMFSL---LPPEEAWRALFMLGLLPALFVLVVRRlvkepeiyrearqr 217
Cdd:cd17315 113 SEIAPAKIRGALGTLNQLMITFG-----ILLAYLLGLalsLSPPGWWRLMFALAAVPALLQLLLMF-------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 218 nqgadkvsfyeiFAPGMLSITLRASLLTTGALGGYYAITAWLPTFLKTERGltvlGTSGYLAMVILGS--YVGYVVSAFL 295
Cdd:cd17315 174 ------------FLPESRALLVGVGLQLLQQLTGINAVMYYAPTIFKSAGG----GTASILASIIVGVvnLLATLVAIRL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 296 TDLIGRKK----NFVLFAVGSFTVVLLYTQLPVSNGAMLW-LGFPLGFFASgiFS-GMGS----FLTELFPTRIRGSGQG 365
Cdd:cd17315 238 VDKVGRRPllliGFAGMAASLLLLAIAFLLPALAKAAGWLaLLGILLYIAA--FAmGAGPvpwlLLSEIFPLRIRGKGMA 315
|
..
gi 15597310 366 FC 367
Cdd:cd17315 316 IA 317
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
78-421 |
6.03e-14 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 73.21 E-value: 6.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 78 GGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQ--------LLVARTLMGFGFGGEWTAGAVLIGEVIKARDR 149
Cdd:PRK10642 73 GGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKR 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 150 GKAVGLVQ----SGWAIGWGLTAILYSLMFSLLPPEEAWRALFMLGLLPALFVLVVRRLVKEPEIY--------REARQR 217
Cdd:PRK10642 153 GFMGSWLDfgsiAGFVLGAGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFqqhvdkleQGDREG 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 218 NQGADKVSFYEIFAPGMLSITLRASLLTTGALGgYYAITAWLPTFLKTERGLTvlgtSGYLAMVILGSYVGYV----VSA 293
Cdd:PRK10642 233 LQDGPKVSFKEIATKHWRSLLTCIGLVIATNVT-YYMLLTYMPSYLSHNLHYS----EDHGVLIIIAIMIGMLfvqpVMG 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 294 FLTDLIGRKKnFVLfaVGSFTVVLL----YTQLPVSNGAMLWLGFPLGFFASGIFSG-MGSFLTELFPTRIRGSGQGFCY 368
Cdd:PRK10642 308 LLSDRFGRRP-FVI--LGSVALFVLaipaFILINSNVIGLIFAGLLMLAVILNCFTGvMASTLPAMFPTHIRYSALAAAF 384
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15597310 369 NAGRAIAALFPMLIGMLGQKLSlGLGIGAFAAVSYGVV-ILAALSLPETRGKQL 421
Cdd:PRK10642 385 NISVLVAGLTPTLAAWLVESTQ-NLMMPAYYLMVVAVIgLITGVTMKETANRPL 437
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
50-385 |
8.94e-14 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 72.27 E-value: 8.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 50 IPTLIALW----GIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLM 125
Cdd:cd17475 15 IPALAPFLqedlHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 126 GFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeeAWRALFM-LGLLPALFVLVVRRL 204
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHY----GWRAAFVvAGLVSILAAVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 205 VKEPEIYREARQRNQGADKVSFYEIFAPGMLSITLRASLLTtgalGGYYAITAWLPTFLKTERGLTVLGTSGYLAMVILG 284
Cdd:cd17475 171 YREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLV----APQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 285 SYVGYVVSAFLTD-LIGRKKNFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPL----GFFASGIFSGMGSFLTELFPTRI 359
Cdd:cd17475 247 GALGRIGLGRVSDrVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLlillGLFAIGWNGLYLTLVAESAGPEQ 326
|
330 340
....*....|....*....|....*.
gi 15597310 360 RGSGQGFCYNAGRAIAALFPMLIGML 385
Cdd:cd17475 327 AGTALGLANTINFIGIAIGPPLFGLL 352
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
34-345 |
1.10e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 71.82 E-value: 1.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 34 IGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQ 113
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 114 NYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeeAWRALFMLGLL 193
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELF----GWRWIFLINVP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 194 PALFVLVvrrlvkepeiyrearqrnqgadkvsfyeifapgmLSITLRASLLTTGALG-GYYAITAWLPTFLKTERGLTVL 272
Cdd:cd17321 159 IGLVALL----------------------------------LARTFSGAVLAAFLLGaALGGLLFLLPLYLQGVLGYSPL 204
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597310 273 GTSGYLAMVILGSYVGYVVSAFLTDLIGRKK----NFVLFAVGSFTVVLLYTQLPVSN--GAMLWLGFPLGFFASGIFS 345
Cdd:cd17321 205 QAGLALLPLALAMLVAAPLAGRLADRFGPRLvlvaGLLLTAVGLLLLALLGADSSVWLllPGLVLLGLGLGLFATPLTN 283
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
50-409 |
5.66e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 69.91 E-value: 5.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 50 IPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGF 129
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 130 GgewtAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEEAWRALF--MLGLLPALFVLVVRRLvKE 207
Cdd:cd17320 102 A----AGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFvfLALLGLLLLLLVLLFL-PE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 208 PEIYREARQRNQGADKVSFYEIFAPgmlsITLRASLLTTGALGGYYAITAWLPTFLKTERGLTVLGTSGYLAMVILGSYV 287
Cdd:cd17320 177 TLPEEKRKPLLSSLLRAYKRVLKNR----RFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALIL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 288 GYVVSAFLTDLIGRKK----NFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFPtRIRGSG 363
Cdd:cd17320 253 GSLLNGRLVRRFGPRRllrlGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTA 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 15597310 364 ---QGFCYNAGRAIAALFPMLIGMLGQkLSLGLGIGAFAAVSYGVVILA 409
Cdd:cd17320 332 salLGFLQFLIGALAGALVGLLPNGTA-LPMGLLILVLGLLALLLLILL 379
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
38-334 |
1.15e-12 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 68.74 E-value: 1.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 38 LDGMDTQMLSFVIPTLIALWGiGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQ 117
Cdd:cd17502 7 LAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTM 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 118 LLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeeAWRALFMLGLLPALF 197
Cdd:cd17502 86 LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHL----SWRWCFYINLPIGGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 198 VLVvrrlvkepeiyrearqrnqgadkvsfyeifapgMLSITLRASLLTTGALGGYYAITAWLPTFLKTERGLTVLGTSGY 277
Cdd:cd17502 162 ALA---------------------------------LLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVR 208
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 15597310 278 LAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVgSFTVV--LLYTQLPVSNGAMLWLGF 334
Cdd:cd17502 209 LLPLIIGLVIGSIISGALISKTGRYKPLIVIGT-ILMSVgaGLLTTLTLDTSKWLLIGY 266
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-202 |
9.25e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.06 E-value: 9.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 26 RRAFWSCKIGYGLDGMDTQMLSFVIPTLIA-LWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAF 104
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAeLGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 105 FTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEEAW 184
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
170
....*....|....*...
gi 15597310 185 RALFMLGLLPALFVLVVR 202
Cdd:cd17325 358 LAAAALLLLAAVLFLLLR 375
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
64-381 |
9.44e-12 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 65.68 E-value: 9.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 64 AGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEV 143
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 144 IKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSllppeeaWRALFMLGLLPALFVLvvrrlvkepeiyrearqrnqgadk 223
Cdd:cd17317 107 VGPKYRSFVGILFGLFWALGYMLLALLAYLIRD-------WRWLQLAISLPGLLFL------------------------ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 224 vsFYEIFAPGMLSITLRASLLTTGAlggYYAITawlptflkteRGLTVLGTSGYLAMVILG--SYVGYVVSAFLTDLIGR 301
Cdd:cd17317 156 --LLLWWLPRRTIIVGLIWFVTSLV---YYGLS----------LNSSNLGGNLYLNFFLSGlvEIPAYFLALLLLDRLGR 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 302 KK---NFVLFAVGSFTVVLLYTQLPVSNGAMLWLgfpLGFFA-SGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAIAAL 377
Cdd:cd17317 221 RWtlsGSLLLAGLACLVTALLPDDENTLALTLAL---VGKFAiSAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAIL 297
|
....
gi 15597310 378 FPML 381
Cdd:cd17317 298 APFI 301
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
40-411 |
1.43e-11 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 65.42 E-value: 1.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 40 GMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLL 119
Cdd:cd17333 9 GLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 120 VARTLMGFGFGGEWTAGAVLIGEVIKaRDRGKAVGLVQSGWAIGwgltAILYSLMFSLLPPEEAWRALF---MLGLLPAL 196
Cdd:cd17333 89 VLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLG----ALIGPLIATSLLTSELSWSWAyliIGLIYLLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 197 FVLVVRRLVKEPEIYREARQRNQGADKVSFYEIFAPGMLSITLrASLLTTGALggyYAITAWLPTFLKTERGLTVLGTSG 276
Cdd:cd17333 164 AILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGAL-ALFLYVGAE---TAFSSWVPSYLVEKKHVSDGLAGY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 277 YLAMVILGSYVGYVVSAFLTDLIGRKKnfVLFAVGSFTVVLLYTQLPVSNGA-MLWLGFPLGFFASGIFSGMGSfLTELF 355
Cdd:cd17333 240 LLSGFWVGITIGRLLGGPISRRIKPHT--LLVLSGSGALLGLLILLLAPTLVvGLVATALLGLFMAALFPTILS-LGISN 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 15597310 356 PTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIGAFAAVsYGVVILAAL 411
Cdd:cd17333 317 LPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITIL-YAIIFVLAL 371
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
73-422 |
1.60e-11 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 65.50 E-value: 1.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 73 LASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKA 152
Cdd:cd17437 43 IISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 153 VGLVQSGWAIGWgLTAILYSLMFSLLPPEEAWRALFMLGLLPALFVLV-VRRLVKEPEIYREARQRNQGADKVSFYEifa 231
Cdd:cd17437 123 TSFPEIFINIGI-LLGYVSNYAFSGLPLHVGWRLMLGVGAVPSLFLAIgVLAMPESPRWTPAVRRMLIAALGIHFFQ--- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 232 pgmlsitlrasllttgALGGYYAITAWLPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKK-------- 303
Cdd:cd17437 199 ----------------QASGIDAVVLYSPRIFKKAGIKSKDKLLLATVAVGVTKTLFILVATFLLDKVGRRPllltstgg 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 304 -NFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASgiFS-GMGS----FLTELFPTRIRGSGQGFCYNAGRAIAAL 377
Cdd:cd17437 263 mTLSLTALATSLTFIDRNGGGLTWALVLAITAVCSFVAF--FSiGAGPitwvYSSEIFPLRLRAQGASLGVVVNRLMSGT 340
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 15597310 378 FPMLIGMLGQKLSLGLGIGAFAAVSYGVVILAALSLPETRGKQLE 422
Cdd:cd17437 341 VSMTFLSMSKAITTGGTFFLFAGVAAAAWVFFYFFLPETKGKSLE 385
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
34-386 |
4.41e-11 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 63.83 E-value: 4.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 34 IGYGLDGMDTQMLS---FVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCG 110
Cdd:cd17360 4 IGGFLFGYDTGVISgalLYIKDDLGEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 111 LAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVgLVQSGWAIGWGLTAILYSLMFSLLPpeEAWRALFML 190
Cdd:cd17360 84 AAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLV-TINVLFITGGQFVAYVINGAFSYLP--GGWRWMLGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 191 GLLPALFVLVVRRLVKEPEIYREARqrnqgadkvsfyeifapgmLSITLRASLLTTGALGGYYAITAWLPTFLKTErGLT 270
Cdd:cd17360 161 AAVPAVLQFIGLLFLPESPRWPSTR-------------------RALIVGCGLQAFQQFSGINTVMYYSATILQMA-GFK 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 271 VLGTSGYLAMVILG-SYVGYVVSAFLTDLIGRKKnFVLFAVGSFTVVLLYTQLPVsngAMLWLGFPLGFFASGIFSGMGS 349
Cdd:cd17360 221 DNQNAIWLSLIVAGtNFIFTIVGMYLIDKFGRRK-LLLISLFGVIVALVVLAVWL---ALVGLILYLAFFAPGMGPVPWT 296
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15597310 350 FLTELFPTRIRGSGQGF----CYNAGRAIAALFPMLIGMLG 386
Cdd:cd17360 297 VNSEIYPLWARGTGGGCaaavNWVFNLLVSQTFLTLTQAIG 337
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
34-387 |
5.06e-11 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 63.93 E-value: 5.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 34 IGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQ 113
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 114 NYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeEAWRALFM---- 189
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAEL---YSWHWVFIvpgi 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 190 LGLLPALFVLVVRRLVKEPEIYREARQ-RNQGADKVSFYEIFAPGMLSITLRASLLTTGALGGY----------YAITAW 258
Cdd:TIGR00881 159 IAIIVSLICFLLLRDSPQSCGLPPAEEmPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISlgyvfvyvvrTGILDW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 259 LPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVL---FAVGSFTVVLLYTQLPVSNGAM-LWLGF 334
Cdd:TIGR00881 239 SPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLavfFMALIIVSLLVYWLNPAANPLMdLICLF 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15597310 335 PLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQ 387
Cdd:TIGR00881 319 ALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLAD 371
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
69-201 |
1.00e-10 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 59.59 E-value: 1.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 69 TMTLLASAAG----GWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVI 144
Cdd:TIGR00880 1 GLLLAGYALGqliySPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 15597310 145 KARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPpeeaWRALFMLGLLPALFVLVV 201
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLG----WRAPFLFLAILALAAFIL 133
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
39-414 |
1.27e-10 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 62.52 E-value: 1.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 39 DGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQL 118
Cdd:cd17442 13 EAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 119 LVARTLMGFGFGGEwTAGAVLIGEVIKARDRGKAVGLVQSGWAIGwgltAILYSLMFSLLPPEEAWRALFMLGLLPALFV 198
Cdd:cd17442 93 VFLRCMVGCGVSGH-SQGLIIKTEFLPTKYRGYMLPLSQIFWLAG----SLLIIGLASVVIPTLGWRWLIRFASIPGIIL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 199 LVVRRLVkePEIYREARQRNQGADKVSFYEIFAPGMLsitLRASLLTTGalGGYYAITAWLPTFLKTERGLTVLGTSGYL 278
Cdd:cd17442 168 IVVFKFI--PRTTLQIWVIWLGISFAYYGVILASSEL---LERNLLCGS--DPSDEEAGIKHIESESPCYCHMFNPSDYQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 279 AMVI--LGSYVGYVVSAFLTDLIGRKKNFVLfAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFP 356
Cdd:cd17442 241 TMIIstLGEIALNPLNILGINFLGRRLSLVI-TMGLTAIFFLLLNICTSSAGLTIFLFMLRALVSANFNTVYIYTAEVYP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15597310 357 TRIRGSGQGFCYNAGRaIAALFPMLIGMLGQKLSLGLGIGAFAAVSYgVVILAALSLP 414
Cdd:cd17442 320 TTMRALGMGTSGSLCR-IGAMVAPFISQVLMSASVLGALCLFSSVCI-VCAISAFTLP 375
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
63-422 |
1.86e-10 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 62.20 E-value: 1.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 63 EAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGE 142
Cdd:cd17433 42 AASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 143 VIKARDRGKAVGLVQ------------SGWAIGWGLTAILYS------LMFSLLPPEEAwRALFMLGLLP----ALFVLV 200
Cdd:cd17433 122 IAHPRVRGTLGSCVQlmvvigimgaylAGLVLDWRWLAVLGSipptlmLLLMCFMPETP-RFLLTQHRRQeamaALRFLR 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 201 VRRLVKEPEIYREARQRNQGADKVSFYEIFAPGMLS-ITLRASLLTTGALGGYYAITAWLPTFLKTERGltvlgTSGYLA 279
Cdd:cd17433 201 GPDQGWEWECIGIEQSFHLEEQSFSLALLKQPGIYKpLIIGVSLMAFQQLTGINAVMFYAETIFEEAKF-----KDSSVA 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 280 MVILGS--YVGYVVSAFLTDLIGRKKNFVLFAVgsftvvllytQLPVSNGAMLWLGF-PLGFFASGIFSGMGS----FLT 352
Cdd:cd17433 276 SVIVAAiqVLFTAVAALIMDRAGRKVLLVLSGV----------VMVFSTAAFGWLAVgSMGFFIAGFAVGWGPipwlVMS 345
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 353 ELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIGAFAAVSYGVVILAALSLPETRGKQLE 422
Cdd:cd17433 346 EIFPLHVRGVASGICVLTNWLMAFLVTKEFSSLMEVLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLE 415
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
65-419 |
3.52e-10 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 61.51 E-value: 3.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 65 GFIHTMTLLASAAGGWIAGILSDRIGR--VLTLQLTVLWF-AFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIG 141
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRknGLLISNALLVVsSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQ 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 142 EVIKARDRGKAVGLVQSGWAIGWGLTAILYslMFSLLPPEEAWRALFMLGLLPALFVLVVRRLVKEP------------- 208
Cdd:cd17357 132 EISPSELRGALGSLTQIGVTLGILLGQVFG--LPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESpkflliskgdeee 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 209 --------------------EIYREARQrNQGADKVSFYEIFA-PGM-LSITLRASLLTTGALGGYYAITAWLPTFLKTE 266
Cdd:cd17357 210 aekslkflrgieddvdqeleEIKKESEQ-MGDQKQVSLMQLLRdPSLrLPLLLVLVVSASQQFSGINAIFFYSTFIFENA 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 267 RGLTVLGTSGYLAMVILgSYVGYVVSAFLTDLIGRK----KNFVLFAVGSFT-VVLLYTQLPVSNGAMLWLGFPLGFfas 341
Cdd:cd17357 289 GFSPQLAEWANLGIGIV-NVLSTIVGPFLIEKVGRRplllISLSVCAVALLLmSVFLFLSEQNSWMSYGCIVAIFLF--- 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 342 GIFSGMG------SFLTELFPTRIRGSGQGFcynaGRAIAALFPMLIGMLGQKLSLGLGIGAFAAVSYGVVILAAL---S 412
Cdd:cd17357 365 IFFFAIGlgpipwFIGAELFPQAPRSAAQSL----GSSVNWTSNFIVGMAFPPLQSIGGGFVFIIFAIPCALFLLYlyrY 440
|
....*..
gi 15597310 413 LPETRGK 419
Cdd:cd17357 441 LPETKGR 447
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
69-411 |
3.40e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 58.35 E-value: 3.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 69 TMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARD 148
Cdd:cd17473 42 TLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 149 RGKAVGLVQSGWAIGwGLTAILYSLMFSLLppeeAWRALFMLGLLPALFVLVVRRLVKEPEIYREAR-----QRNQGADK 223
Cdd:cd17473 122 RAKMLGLQSAAMSLG-GVVFLLLGGALAEI----GWRAPFLVYLLALPVLILVLLFLPEPARKSKSAaspgaATAAALPW 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 224 VSFYEIFAPGMLSITLrasllttgalggYYAITAWLPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKK 303
Cdd:cd17473 197 KRVLPIYFLAFLAMLL------------FYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 304 ----NFVLFAVGSFTVVLLYTQLPVSNGAMLWlgfplGFFASGIFSGMGSFLTELFPTRIRGSGQGF---CYNAGRAIAA 376
Cdd:cd17473 265 llaiGFALMALGFLLLALASGLWVVLLGAILA-----GLGFGLLLPTLNSWAMSLVPPELRGRAMGIvtsAFFLGQFLSP 339
|
330 340 350
....*....|....*....|....*....|....*
gi 15597310 377 LFPMLIGMLGQKLSLGLGIGAFAAVSYGVVILAAL 411
Cdd:cd17473 340 LVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
39-212 |
4.65e-09 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 58.45 E-value: 4.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 39 DGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQL 118
Cdd:TIGR01299 179 DGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFF 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 119 LVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAIL-------YSLMFSLLPPEE--AWRALFM 189
Cdd:TIGR01299 259 LFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMawaiiphYGWSFQMGSAYQfhSWRVFVI 338
|
170 180
....*....|....*....|...
gi 15597310 190 LGLLPALFVLVVrrLVKEPEIYR 212
Cdd:TIGR01299 339 VCAFPCVFAIGA--LTFMPESPR 359
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
41-339 |
5.08e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 57.59 E-value: 5.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 41 MDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLV 120
Cdd:cd17503 10 LDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLII 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 121 ARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLV----QSGWAIGWGLTAILYSLMfsllppeeAWRALFMLGLLPAL 196
Cdd:cd17503 90 FRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVglviLLAPAIGPTLGGWLTDNL--------SWRWIFYINLPIGI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 197 FVLVVRRLVKepeiYREARQRNqgadkvsfyeifapgmlsitLRASLLTTGALG-GYYAITAWLPTFLKTERGLTVLgTS 275
Cdd:cd17503 162 LALLLAPLLD----LRLFKDRN--------------------FTLGLLLSFLLGlGLFGAMFLLPLYLQNVLGYSAF-ES 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597310 276 GYLAM-VILGSYVGYVVSAFLTDLIGRKK----NFVLFAVGS--FTVVLLYTQLPVSNGAMLWLGFPLGFF 339
Cdd:cd17503 217 GLVLApGGLASAILSPLVGRLLDKFGPRLlllaGLLLLALGTllLAFLTPDTSLWLIILPLFIRGLGMGLV 287
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
43-412 |
7.87e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 57.24 E-value: 7.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 43 TQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLT-----VLWFAFFTFLCGLAQNYEQ 117
Cdd:cd06173 15 DWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllraLLAAVLALLALLGSLSLWL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 118 LLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEeaWRALFMLGLLPALF 197
Cdd:cd06173 95 LLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPG--GAFAINALSFLLSA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 198 VLVVRRLVKEPEIYREARQRNQGADKVSFYEIFAPGMLSITLRASLLTTGALGGYYAItawLPTFLKTERGLTVLGTSGY 277
Cdd:cd06173 173 LLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVL---LPLLAKEVLGGGAAGYGLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 278 LAMVILGSYVGyvvSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQLPVSNGAMLWLG--FPLGFFASGIFSGMGSFLTELF 355
Cdd:cd06173 250 LAAFGVGALLG---ALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAalFLLGLAGGLFNVPLNTLLQLRV 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 15597310 356 PTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIGAFAAVSYGVVILAALS 412
Cdd:cd06173 327 PDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
44-401 |
9.21e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 56.83 E-value: 9.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 44 QMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVART 123
Cdd:cd17489 13 YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 124 LMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeeAWRALFMLGLLPALFVLVVRR 203
Cdd:cd17489 93 IHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL----GFAVLFIVAAVLALLALLLVF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 204 LVKEPEIYREARQRnqgADKVSFYEIFAPGMLSItlraSLLTTGALGGYYAITAWLPTFLKtERGLTVLGTsgYLAMVIL 283
Cdd:cd17489 169 LVKDPPPVAAEEAE---AGTRAFRRLVEKKVLPP----ALILFLASIAYGAISTFLPLYAA-ERGISNAGL--FFTVYAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 284 GSYVGYVVSAFLTDLIGRKKnFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSG 363
Cdd:cd17489 239 ALLLSRPFSGKLSDRKGPKT-VIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAA 317
|
330 340 350
....*....|....*....|....*....|....*...
gi 15597310 364 QGFCYNAGRAIAALFPMLIGMLGQKLSLGlGIGAFAAV 401
Cdd:cd17489 318 NGTFFIFFDLGIGLGGLLLGLVAELFGYR-AMFLLAAV 354
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
49-410 |
1.48e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 56.03 E-value: 1.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 49 VIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFG 128
Cdd:cd17477 18 LLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 129 FGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEEAWRALFMlgLLPALFVLVVRRLVKEP 208
Cdd:cd17477 98 LAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLL--LLALVPLLLTRRAAPEI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 209 EiyrearqrnqGADKVSFYEIF--APGMLSITLRASLLTTgalggyyAITAWLPTFLkTERGLTVLGTSGYLAMVILGSY 286
Cdd:cd17477 176 E----------EAESISLRRLLriAPLALLGAFVAGFLEG-------AFYSLLPLYG-LRLGLSVAQAALLLAAFVLGGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 287 VGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFP--TRIRGSGQ 364
Cdd:cd17477 238 LLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPgdELVAANAA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 15597310 365 -GFCYNAGRAIAalfPMLIGMLGQKLSlGLGIGAFAAVSYGVVILAA 410
Cdd:cd17477 318 lLLLYGLGSVIG---PLLAGALMDAFG-PHGLFLFLAAVALLFLLFL 360
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
49-401 |
2.27e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 55.66 E-value: 2.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 49 VIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFG 128
Cdd:cd17323 21 ALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 129 FGGEWTAGAVLIGEVIKARDRGKAVGLvqsgWAIGWGLTAILYSLMFSLLPPEEAWRALFMLGLLPALFVLVVrrlvkep 208
Cdd:cd17323 101 GSSPLAIGAGTIADLFTPEERGKAMGV----YSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLIL------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 209 eiyrearqrnqgadkVSFyeiFAPGMLSITLRASLLttgaLGGYYAITAWLPTFLKTERGLTVLGT-----SGYLAMVIL 283
Cdd:cd17323 170 ---------------IFL---FLPIVLLLGLYVGLV----YAILYLFLTAFPYVFGEVYGFSPGEVglmylPIGIGALIG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 284 GSYVGYVVSAFLTDLIGRKKNFVLFAvgsFTVVLLYTQLPVSNGAMLWLG----------------FPLGFFASGIFSGM 347
Cdd:cd17323 228 SIIGGRLSDYYYRRLKKKNGGKPEPE---ARLPPAFIGAFLFPIGLFIFGwtiyphihwivpiigsAFFGFGLMLIFQSS 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15597310 348 GSFLTELFPTRIRG--SGQGFCYNAGRAIAALF--PMLIGMLGQKLSLGLGIGAFAAV 401
Cdd:cd17323 305 LTYLVDSYPKYAASalAANTLVRSIFAAIFPLFaqPMFNNLGVGWAFTLLAFISLAMI 362
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
33-413 |
3.11e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.29 E-value: 3.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 33 KIGYGLDGMDTQMLSFVIPTLIAL-----WGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIG-----RVLTLQLTVLWF 102
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLLSAYLLYfytdvLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 103 AFFTFLCGLAQNYEQ------LLVARTLMGFGFGGEWTAGAVLIGEVIK-ARDRGKAVGLVQSGWAIGWGLTAILYSLMF 175
Cdd:COG2211 92 ALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 176 SLLP--PEEAWRALFML-GLLPALFVLVVRRLVKEpeiyREARQRNQGADKVSFYEIFAPGMLSITLRASLLTTGAlggY 252
Cdd:COG2211 172 AAFGgdAALGYRLTALIfAVLGLLAFLLTFFGTKE----RPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLA---L 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 253 YAITAWLPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQLPVSNGAMLWL 332
Cdd:COG2211 245 ALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 333 GFPL-GFFASGIFSGMGSFLTELFP-------TRIRG---SGQGFCYNAGRAIA-ALFPMLIGMLGQKLSLGLGIGAFAA 400
Cdd:COG2211 325 LAALaGIGLGAILVLPWAMLADVVDydewktgRRREGlyfGIFTFAIKLGQALAgALAGLLLALFGYVAGAAQSPSALTG 404
|
410
....*....|...
gi 15597310 401 VSYGVVILAALSL 413
Cdd:COG2211 405 IRLLFFLLPAVLL 417
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
58-408 |
3.36e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 54.93 E-value: 3.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 58 GIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGA 137
Cdd:cd17329 31 GLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASE 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 138 VLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPpeeawRALFMLG-LLPALFVLVVRRLVKEPEIYREARQ 216
Cdd:cd17329 111 AMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF-----RLLFLAAaVLFLLAALVLLFLLPETRPKRRAAE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 217 RNqgadkvsfyEIFAPGMLSITLRASLLTTGALGGYYAITAW----LPTFLKTERGLTVLGTSGYLA----MVILGSYvg 288
Cdd:cd17329 186 KT---------EILRGYKIVLRDRAFLLFLLASFLISLIYFQlestLPVYVVEILGLGESLLGLLLAlnalLIVLLQF-- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 289 yvvsaFLTDLIGRKKNFVLFAVGsftvVLLYTqlpVSNGAMLWLGFPLGFFASGIFSGMG---------SFLTELFPTRI 359
Cdd:cd17329 255 -----PVARLVERFRLRKILMIG----ILLFA---IGFAVLAFANTLAVLILAMIVLTLGemlvfpavqTLVAALAPPDK 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 15597310 360 RGSGQGF---CYNAGRAIAalfPMLIGMLGQKLSLGLGIGAFAAVSYGVVIL 408
Cdd:cd17329 323 RGSYMGFyalAWGLGRAIG---PLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
58-422 |
6.98e-08 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 54.28 E-value: 6.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 58 GIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGA 137
Cdd:cd17362 35 NLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 138 VLIGEVIKARDRGKAVGLVQSGWAIGwgltaIL--YSLMFSLLPPEEAWRALFMLGLLPALFV-LVVRRLVKEPEIYREA 214
Cdd:cd17362 115 VYIAETSPSHIRGLLVSLKELFIVLG-----ILlgYVSGYAFADVVGGWRYMYGLAAPPALLLgIGMWFLPPSPRWQGNY 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 215 RQRNQGADKVSFYEifapgmlSITLRASLLttgalggYYAitawlPTFLKTERglTVLGTSGYLAMVILGSY--VGYVVS 292
Cdd:cd17362 190 RKPLIIGLGLVLFQ-------QITGQPSVL-------YYA-----ATIFKSAG--FSAASDATLVSVGLGVFklLMTIVA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 293 AFLTDLIGRKKNFV----LFAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASGIFS-GMGS----FLTELFPTRIRGSG 363
Cdd:cd17362 249 VLLVDKLGRRPLLLggvsGMVVSLFLLAAYNLFVQMGPAGLAWLSLVALLLYVGAYQiSFGPiswlMVSEIFPLRVRGRA 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15597310 364 QGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIGAFAAVSYGVVILAALSLPETRGKQLE 422
Cdd:cd17362 329 IALAVLVNFGSNALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFIYFTVPETKGLSLE 387
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
23-223 |
1.23e-07 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 53.58 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 23 KQERRAFWSCKIGYGLDGMD------TQMLSF-------VIPTLIALWGIGTGEAGFihtmtlLASAAGGWIAGILSDRI 89
Cdd:PRK09952 18 SRARRAALGSFAGAVVDWYDfllygiTAALVFnreffpqVSPAMGTLAAFATFGVGF------LFRPLGGVVFGHFGDRL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 90 GRVLTLQLTVLWFAFFTFLCGLAQNYEQ-------LLVA-RTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWA 161
Cdd:PRK09952 92 GRKRMLMLTVWMMGIATALIGLLPSFSTigwwapvLLVTlRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYG 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597310 162 IGWGLTAILYSLMFSLLPPEE----AWRALFMLGLLPALFVLVVRRLVKEPEIYREARQRNQGADK 223
Cdd:PRK09952 172 VGLLLSTGLVSLISMMTTDEQflswGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKK 237
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
39-207 |
1.37e-07 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 53.39 E-value: 1.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 39 DGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQL 118
Cdd:cd17438 11 DGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 119 LVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIG--------WGLTAiLYSLMFSLLPPEE--AWRALF 188
Cdd:cd17438 91 LFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGglyasamaWSIIP-HYGWGFSMGTNYHfhSWRVFV 169
|
170
....*....|....*....
gi 15597310 189 MLGLLPALFVLVVRRLVKE 207
Cdd:cd17438 170 IICALPCIASIIALKFMPE 188
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
39-264 |
1.73e-07 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 52.99 E-value: 1.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 39 DGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQL 118
Cdd:cd17440 11 DGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 119 LVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIG--------WGLTAiLYSLMFSLLPPEE--AWRALF 188
Cdd:cd17440 91 LFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGgiyasamaWAIIP-HYGWSFSMGSAYQfhSWRVFV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 189 MLGLLPALFVLVVRRLVKE-PEIYREA------------------RQRNQGADKVSFYEIFAPGMLSITLRASLLTTgal 249
Cdd:cd17440 170 IVCALPCVSSVVALTFMPEsPRFLLEVgkhdeawmilkqihdtnmRARGQPEKVFTVNRIKKDNTIKLTIVWLTLSF--- 246
|
250
....*....|....*
gi 15597310 250 gGYYAITAWLPTFLK 264
Cdd:cd17440 247 -GYYGLSVWFPDVIK 260
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
27-201 |
1.91e-07 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 53.15 E-value: 1.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 27 RAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFT 106
Cdd:TIGR00711 2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 107 FLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeeAWRA 186
Cdd:TIGR00711 82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENY----HWRW 157
|
170
....*....|....*
gi 15597310 187 LFMLGLLPALFVLVV 201
Cdd:TIGR00711 158 IFLINVPIGIIVVVV 172
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
87-401 |
1.99e-07 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 53.02 E-value: 1.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 87 DRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQL--------LVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLvQS 158
Cdd:PRK15075 81 DRVGRRKGLIVTLSIMASGTLLIAFVPGYATIglaapllvLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSW-QS 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 159 G---------WAIGWGLTAilyslmfsLLPPEE----AWRALFMLGLLPALFVLVVRRLVKEPEIYREARQRnqgadkVS 225
Cdd:PRK15075 160 AsqqvavvfaALLGYLLNQ--------WLSPAQmaewGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKHR------PS 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 226 FYEIFApGMLS---ITLRASLLTTGALGGYYAITAWLPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRK 302
Cdd:PRK15075 226 MREIFR-SLAAnwrIVLAGMLMVAMTTVSFYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRR 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 303 KnfVLFAvgsFTVVLLYTQLPV--------SNGAMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAI 374
Cdd:PRK15075 305 P--VLIA---FTVLAILTAYPAlswlvaapSFARMLAVELWLSFLYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLATAI 379
|
330 340 350
....*....|....*....|....*....|..
gi 15597310 375 AALF-PM----LIGMLGQKLSLGLGIgAFAAV 401
Cdd:PRK15075 380 FGGFtPAistwLIHVTGDKAAPGYWL-SFAAV 410
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
45-207 |
2.07e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.56 E-value: 2.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 45 MLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGR--VLTLQLTVLWFAFFTFLCGLAQNYEQLLVAR 122
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 123 TLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEEAWRALFMLGLLPALFVLVVR 202
Cdd:COG2271 279 FLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
....*
gi 15597310 203 RLVKE 207
Cdd:COG2271 359 RETRK 363
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
45-413 |
2.27e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 52.58 E-value: 2.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 45 MLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTL 124
Cdd:cd17504 14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 125 MGFGfGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeeAWRALFMLGLLPALFV-----L 199
Cdd:cd17504 94 QGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHL----GWRWIFWTAAPVAVLLaalvpL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 200 VVRRLVKEPEIyrearqrnqgadkvsfyeifapGMLSITlrASLLTTGALGGYYAITAWLPTFLKTERGLTVLGTSGYLA 279
Cdd:cd17504 169 IDLRLLRRRNV----------------------LLANIT--ALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 280 MVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFPTRI 359
Cdd:cd17504 225 PGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDR 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 15597310 360 RGSGQGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIGAF---AAVSYGVVILAALSL 413
Cdd:cd17504 305 TGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGVpteGAYVLAFLIGAALAL 361
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
8-422 |
6.47e-07 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 51.27 E-value: 6.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 8 DASRDGHFGWYraldkqERRAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEA-----GFIHTMTLLASAAGGWIA 82
Cdd:TIGR00887 3 EEADTAPFGWQ------HFRAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYHGKGPLpssvsAAVNGSASIGTLAGQLFF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 83 GILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVA------RTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLV 156
Cdd:TIGR00887 77 GWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMatlcfwRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 157 --QSGWAI-GWGLTAILYSLMFSLLPPEEA----------------WRALFMLGLLPALFVLVVRrlVKEPEIYRE---- 213
Cdd:TIGR00887 157 faMQGFGIlAGAIVALIVLAGFKHSLEAAAdeasctgscvpavdymWRILIGFGAVPALLALYFR--LTIPETPRYtadv 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 214 ARQRNQGADKVSFYEIFAPGMLSITLRAsllTTGALGGYYAITAWLPT-FLKTERGLTVLGTS----------------- 275
Cdd:TIGR00887 235 AKDVEQAASDMSAVLQVKIEAEPDEVEK---ASTAVEVPKASWSDFFThFFKWRHGKHLLGTAgswflldiafygvnlnq 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 276 ---------------------------GYLAMVILGSYVGYVVSAFLTDLIGRK----KNFVLFAVgsFTVVLLYTQLPV 324
Cdd:TIGR00887 312 kvilsaigysppaatnnayeelyktavGNLIIALAGTVPGYWVTVFLVDIIGRKpiqlMGFFILTV--LFFVLGFAYNHL 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 325 SNGAMLWLgFPLGFFasgiFSGMGSFLT------ELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIGAF 398
Cdd:TIGR00887 390 STHGFLAI-YVLAQF----FANFGPNATtfivpgEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQHGDPTKGYPTG 464
|
490 500 510
....*....|....*....|....*....|...
gi 15597310 399 AAVSYGVVILAA---------LSLPETRGKQLE 422
Cdd:TIGR00887 465 IWMGHVLEIFALfmflgilftLLIPETKGKSLE 497
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
242-419 |
9.97e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.49 E-value: 9.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 242 SLLTTGALGGYYAITAWLPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKnFVLFAVGSFTVVLLYTQ 321
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRR-VLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 322 LPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIGAFAAV 401
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|....*...
gi 15597310 402 SYGVVILAALSLPETRGK 419
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESK 178
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
34-378 |
1.17e-06 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 50.41 E-value: 1.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 34 IGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRI--------GRVLTLQLTVLW---- 101
Cdd:cd17343 10 VGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQIsarwlfssGLVLSGLTTVAFsgss 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 102 ----FAFFTFLCGLAQnyeqllvartlmgfGFGgeWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSL 177
Cdd:cd17343 90 svwvFSILWFLNGLAQ--------------GLG--WPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 178 LppeeAWRALFML----GLLPALFVLVVRR-------LVKEPEIYREARQRNQGADKVSFYE-IFAPGMLSITLRaSLLT 245
Cdd:cd17343 154 Y----GWRSTLSIsgtvAVVMSVVCLLFIKnepsdvgLNNIEEEESKGKKKKSPRGESTLKElLLSPFLWLLSLG-YLVV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 246 TGAlggYYAITAWLPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYTQL--- 322
Cdd:cd17343 229 FGV---KTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVFMAGltv 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15597310 323 -----------PVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGsgqgfcynAGRAIAALF 378
Cdd:cd17343 306 slhlfrvhitsDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCG--------TSHAIVALA 364
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
63-422 |
1.47e-06 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 50.22 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 63 EAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGE 142
Cdd:cd17434 42 QISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 143 VIKARDRGKAVGLVQsgwaigwgLTAILYSLMFSLLPPEEAWRALFMLGLLPALFVLVVRRLVKEPEIYREARQRNQGA- 221
Cdd:cd17434 122 ISHPGVRGALGACPQ--------IMAVFGSLALYALGLLLPWRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKAl 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 222 -----------DKVSFYEIFAPGMLSITLRASLLTTGALGGYYAIT-AWLPTFLKTERGLT----VLGTSGYLAMVIL-- 283
Cdd:cd17434 194 kalawlrgpntDYMTEFEQIKDNIRKQSSRLSWAELKTPSYYKPILiAVVMRFLQQLTGITpilvYLEPIFHLTAVILep 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 284 ---GSYVGYV------VSAFLTDLIGRKknfvlfavgsftvVLLYTQLPVSNGAMLWLGF-PL---GFFASGIFSGMGS- 349
Cdd:cd17434 274 kydAALVGAVrllsvaIAASLMDKAGRK-------------ILLFTSAFLMFAANLSMGLiPLiaaMLFIMGYAMGWGPi 340
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597310 350 ---FLTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIGAFAAVSYGVVILAALSLPETRGKQLE 422
Cdd:cd17434 341 twlLMSEILPLKARGVASGLCVVVSWITAFVLTQLFLPVVVTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLE 416
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
78-387 |
1.84e-06 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 49.60 E-value: 1.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 78 GGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQ 157
Cdd:cd17374 51 GALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 158 SGWAIGWGLTAilySLMFSLlppeEAWRALFMLGLLPA-LFVLVVRRLVKepeiyrearqrnqgadkvsfyeifapgmls 236
Cdd:cd17374 131 CFFSIGQMLLA---GLAYAI----RDWRLLQLVVSVPFfLFFLYSWWLPK------------------------------ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 237 ITLRASLLTTGALGGYYAITAwlptflkterGLTVLGTSGYLAMVILGS--YVGYVVSAFLTDLIGRKKNFVLFAVGSFT 314
Cdd:cd17374 174 RTLILSFVWFANSFSYYGLSL----------DLQHLGLNVFLLQFLFGAveVPARCLALFLLNHMGRRISQAVLLLLAGL 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597310 315 VVLLYTQLPVSNGAMLWLGFPLGFFASGI-FSGMGSFLTELFPTRIRGSGQGFCYNAGRAIAALFPmLIGMLGQ 387
Cdd:cd17374 244 CILANIFVPQEMQTLRTVLAVLGKGSSAAaFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAP-LIMLLGV 316
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
72-423 |
3.09e-06 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 49.03 E-value: 3.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 72 LLASAAGGwiagILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGK 151
Cdd:cd17435 50 LLASLTGG----VLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 152 AVGLVQSGWAIGWgLTAILYSLMFSLLPpeEAWRALFMLGLLPALFVLVVRRLVKEPEIYREARQrnqgadkvsfyEIFA 231
Cdd:cd17435 126 LVSLNELMIVIGI-LLAYISNYAFANVS--NGWKYMFGLVIPLAALQAIAMYFLPPSPRFLVMKD-----------NMRA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 232 PGMLSITLRASLLTTGALG-GYYAITAWLPTFLKTERGLTVLGTSGYLAMVilgsyVGYVVSAFLTDLIGRKknfVLFAV 310
Cdd:cd17435 192 RLLIGLTLVFFVQITGQPNiLFYASTVLKSVGFQSNEAASLASTGVGVVKV-----VSTIPAIFLVDKVGSK---TFLCI 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 311 GSFTVVLLYTQLpvsnGAMLWLGFPLGFFASgiFS-GMGSF----LTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGML 385
Cdd:cd17435 264 GSSVMAVSLVTM----GLWLSLASLLVYVAA--FSiGLGPMpwlvLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTV 337
|
330 340 350
....*....|....*....|....*....|....*...
gi 15597310 386 GQKLSLGLGIGAFAAVSYGVVILAALSLPETRGKQLEL 423
Cdd:cd17435 338 TELIGLPWVCFIYTAMSLASLVFVIMFVPETKGCSLEQ 375
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
39-264 |
3.18e-06 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 49.26 E-value: 3.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 39 DGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQL 118
Cdd:cd17439 11 DGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 119 LVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAIL-------YSLMFSLLPPEE--AWRALFM 189
Cdd:cd17439 91 LFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMawaiiphYGWSFQMGSAYQfhSWRVFVL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 190 LGLLPALFVLVVRRLVKE-PEIYREARQRNQG---ADKVSFYEIFAPG----MLSITLRASLLTTGALG-------GYYA 254
Cdd:cd17439 171 VCAFPSVFAIGALTTMPEsPRFFLENGKHDEAwmvLKQVHDTNMRAKGhperVFSVTHIKRRITLMMMAvwftmsfSYYG 250
|
250
....*....|
gi 15597310 255 ITAWLPTFLK 264
Cdd:cd17439 251 LTVWFPDMIK 260
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
45-352 |
3.40e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 48.79 E-value: 3.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 45 MLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLA-QNYEQLLVART 123
Cdd:cd17341 17 LFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAvSSYWGLLVLGF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 124 LMGFGfGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMF---SLLPPEEAWR-ALFMLGLLPALFVL 199
Cdd:cd17341 97 LLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAgaiVFDGGFVGWRnAFFVPGILLAIAAV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 200 VVRRLVKEPEiyreaRQRNQGADKVSfyEIFAPGMLSITLRASLLTTGALGGYYAITAWLPTFLKTERGLTVLGTSGYLA 279
Cdd:cd17341 176 LVLLFGDDLP-----TGKASALEFLK--VQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAA 248
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597310 280 MVILGSYVGYVVSAFLTDLIG-RKKNFVLFAVGSFTVVLLYTQLPVSNGAMlwLGFPLGFFASGIFSGMGSFLT 352
Cdd:cd17341 249 LFPLAGALARPAGGWLSDRFGgRRRLWWLFIVMTIGAALLSLSLPTSGTNL--VLFLALFVALGLGAGAGNGSV 320
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
49-201 |
3.48e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 48.74 E-value: 3.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 49 VIPTLIALWGIGTG--EAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMG 126
Cdd:cd17489 212 AISTFLPLYAAERGisNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYG 291
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597310 127 FGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeeAWRALFMLGLLPALFVLVV 201
Cdd:cd17489 292 LGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF----GYRAMFLLAAVVVLLALVL 362
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
78-156 |
3.75e-06 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 48.50 E-value: 3.75e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597310 78 GGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRgKAVGLV 156
Cdd:cd17379 49 GSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYR-RTVGIV 126
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
46-411 |
4.13e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 48.41 E-value: 4.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 46 LSFVIPTLIALWgigtgeAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLM 125
Cdd:cd17391 26 LGVTSGGLVELW------SGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQ 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 126 GFgFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGwgltAILYSLMFSLLPPEEAWRALFML-GLLPALFVLVVRRL 204
Cdd:cd17391 100 GV-FSGYVPNATALIASQTPKEKSGWALGTLSTGVVAG----TLIGPLLGGFLADLFGIRNVFFItGGLLFLAFLLTLFF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 205 VKepEIYREARQRNQGADKVSFYEIFAPGMLSITLRASLLTTGALggyYAITAWLPTFLK--TERGLTVLGTSGylaMVI 282
Cdd:cd17391 175 VK--EDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLAN---QSIEPILTLYIRqlMGDASNLAFISG---LVF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 283 LGSYVGYVVSAF----LTDLIGRKKnfVLFAVGSFTVVLLYTQLPVSNGAML-WLGFPLGFFASGIFSGMGSFLTELFPT 357
Cdd:cd17391 247 SATGVSSLLSAPrlgkLGDRIGHHR--ILLGALLASALLYIPQAFVQTPWQLgILRFLLGLATGGLLPAINSLLAKITPK 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15597310 358 RIrgSGQGFCYNA-----GRAIAAlfpmligMLGQKLSLGLGIGAFAAVSYGVVILAAL 411
Cdd:cd17391 325 EV--AGRIFGYNQsfqylGNVAGP-------LLGSAIAAHFGYRAVFVVTALLVLLNAI 374
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
64-413 |
4.18e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 48.34 E-value: 4.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 64 AGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVlIGEV 143
Cdd:cd17330 36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAY-IADI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 144 IKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEEAWRALFMLGLLPALFVLvvrrlvkepeiyrearqrnqgadk 223
Cdd:cd17330 115 TDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVL------------------------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 224 vsfyeiFAPGMLSITLRASLLTTGALGGYYAItawLPTFLKTERGLTVLGTSGYLAMV-ILGSYVGYVVSAFLTDLIGRK 302
Cdd:cd17330 171 ------FFLPPLRRLLLVYFLIALAFAGLESV---FSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLIPRLAKRLGER 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 303 KnfvLFAVGSFTVVLLYTQLPVSN--GAMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCynagRAIAALFPM 380
Cdd:cd17330 242 K---LLRLGLLLAIIGLLLLPFASsvPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGII----QSLQSLARI 314
|
330 340 350
....*....|....*....|....*....|...
gi 15597310 381 LIGMLGQKLSLGLGIGAFAAVSYGVVILAALSL 413
Cdd:cd17330 315 IGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLL 347
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
78-408 |
4.36e-06 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 48.51 E-value: 4.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 78 GGWIAGILSD-RIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLV 156
Cdd:cd17378 49 GSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPKWRGQVGMST 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 157 QSGWAIGWGLTAILYSLMFSllppeeAWRALFMLGLLPALFVLV-----VRRLVkepeiyrearqrnqgadkVSFYEIFA 231
Cdd:cd17378 129 FFFFVLGFMSLPGIAYLNGS------SWRVLYFWTSIPALIYCIlvylfARRLL------------------AVMVIGFG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 232 PGMLsitlrasllttgalggYYAITAwlptflkterGLTVLGTSGYLAMVI--LGSYVGYVVSAFLTDLIGRKKNFVLFA 309
Cdd:cd17378 185 IGMV----------------YYGIPL----------AVGNLKFNIYLSVALnaLSELPAFVITAFLLDRFGRRPSLLGFT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 310 VGSFTVVLLYTQLPVSNGAMLWLGFPLG--FFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQ 387
Cdd:cd17378 239 LLSGASCLLCFVLSIGGTTSLQIALELVgfFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRK 318
|
330 340
....*....|....*....|.
gi 15597310 388 KLSLGLGIGAFAAVSYGVVIL 408
Cdd:cd17378 319 NAALSFGVFGVAILLLGLFAL 339
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
41-408 |
6.20e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.92 E-value: 6.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 41 MDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIG-RVLTLQLTVLWFAFFTFLCGLAQNYEQLL 119
Cdd:cd17370 13 ISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 120 VARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppEEAWRALFMLGLLPALF-V 198
Cdd:cd17370 93 LLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLL--GGNYRTIFLLAAIPALLaL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 199 LVVRRLVKEPEIYREARQRNQGADKVSFYEIFAPGMLSITLRASLLTTGALGGYYAITAWLPTFlktergltvLGTSGYL 278
Cdd:cd17370 171 LILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLSAA---------LIPLLYA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 279 AMVILGSYVGYVVsAFLTDLIGRKKNFVLFAVGSFTVVLLYtqLPVSNGAMLWLGFPLGFFASGIF-SGMGSFLTELFPT 357
Cdd:cd17370 242 LFNLVYALAAYPA-GRLSDRIGRKKLLILGYLSLALAYLGF--ALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPA 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 15597310 358 RIRGSGQGFcYNAGRAIAALF-PMLIGMLGQKLSLGLGIGAFAAVSYGVVIL 408
Cdd:cd17370 319 ELRGTAYGL-FNTVVGIGWLLaSLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
27-413 |
1.23e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.88 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 27 RAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFT 106
Cdd:cd17312 3 RIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALAN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 107 FLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLppeeAWRA 186
Cdd:cd17312 83 IFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY----GWRA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 187 LFML-GLLPALFVLVVRRLVKEPEiyrearqrnqgadkvsfyeifaPGMLSITLrASLLTTGAlggYYAITAWLPTFLKT 265
Cdd:cd17312 159 AFLVpGIVGLVVAIILFFFLRDSP----------------------PYVWVLSL-AYAFVYIV---RYACLDWGPLYLYE 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 266 ERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIG---RKKNFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASG 342
Cdd:cd17312 213 VKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFggrRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGG 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597310 343 IFSGMGSFLTELFPTR-IRGSGQGFCYNAGRAIAALFPMLIGMLGQKLSlGLGIGAFAAVSYGVVILAALSL 413
Cdd:cd17312 293 PINLIGGAAAQDIGRKeAAGTATGFVGLFGYLGASLAGLPLGYIIDHYG-WSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
39-209 |
1.39e-05 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 47.10 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 39 DGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQL 118
Cdd:cd17363 11 DGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 119 LVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIG--------WGLTAiLYSLMFSLLPPEE--AWRALF 188
Cdd:cd17363 91 LFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGglyasamaWAIIP-HYGWGFSMGTAYQfhSWRVFV 169
|
170 180
....*....|....*....|.
gi 15597310 189 MLGLLPALFVLVVrrLVKEPE 209
Cdd:cd17363 170 IVCALPSVASVVA--LTFMPE 188
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
44-166 |
1.87e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 46.85 E-value: 1.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 44 QMLSFVIPTLIALWGiGTGEAGFIHTMTLLASAAGGWIAGILSDRIGR----VLTLQLTVLWFAfftfLCGLAQNYEQLL 119
Cdd:cd06179 15 TLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRrwffIGGNLLGVVGSI----VAGTAKSVNMLI 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 15597310 120 VARTLMGFGFGGEwTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGL 166
Cdd:cd06179 90 GGQALIGIGAGTQ-GLGAAVASELVPNKYRGLVQGVVNLVASPGSAL 135
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
81-206 |
4.36e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 45.24 E-value: 4.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 81 IAGILSDRIGRVLTLQLTVLWFAFFTFLCGLA--QNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQS 158
Cdd:cd17380 53 LGGYLADRFGGKKVLLLAVALWSLATLLTPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTA 132
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 15597310 159 GWAIGwgltAILYSLMFSLLPPEEAWRALF-MLGLLPALFVLVVRRLVK 206
Cdd:cd17380 133 GSYLG----TLLGGLIGPLLLEYYGWPSVFyFFGLLGLLWALVWLIYLP 177
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
26-206 |
5.42e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.88 E-value: 5.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 26 RRAFWSCKIGYGLDGMDTQMLSFVIPTLIAL-----WGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIG--RVLTLQLT 98
Cdd:cd17504 176 RRNVLLANITALLAGFGMFMVFQLLPQLLQLptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGprRVLLIGLV 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 99 VLWFAFFtFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGL-TAILYSLM--- 174
Cdd:cd17504 256 ISAVGLL-LLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIgPAIAGAILtty 334
|
170 180 190
....*....|....*....|....*....|....*..
gi 15597310 175 -----FSLLPPEEAWRALFMLGLLPALFVLVVRRLVK 206
Cdd:cd17504 335 tvsitSGGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
43-202 |
6.24e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 6.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 43 TQMLSFVIPT-----LIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQ 117
Cdd:cd17473 209 AMLLFYVIPIqlpflLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWV 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 118 LLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLP-PEEAWRALFMLGLLPAL 196
Cdd:cd17473 289 VLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGgLSGAFLILGVLALVLAI 368
|
....*.
gi 15597310 197 FVLVVR 202
Cdd:cd17473 369 VLLLLR 374
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
51-413 |
8.82e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 44.52 E-value: 8.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 51 PTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIG-RVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGF 129
Cdd:cd17353 27 PPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGpRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 130 GgewTAGAVLIGEVIK--ARDRGKAVGLVqsgwAIGWGLTAILYS-LMFSLLPPEEAWRALFMLGLLPALFVLVVRRLVK 206
Cdd:cd17353 107 G---IGYITPVSTAVKwfPDKRGLATGIV----IAGFGLGSLIFSpLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 207 EPE--IYREARQRNQGADKVSFYEIFAPGMLSITLRASL---LTTGALGGYYAITAWLPtFLKTERGLTVLGTSGYLAMV 281
Cdd:cd17353 180 DPPkgWVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLwlmFFLNATAGLMLIGQAKP-IGQEFAGLDAGIAALAVSIL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 282 ILGSYVGYVVSAFLTDLIGRKKN-FVLFAVGSFTVVLLYTQLPVSNGAMLWLGFpLGFFASGIFSGMGSFLTELFPTRIR 360
Cdd:cd17353 259 SIFNGGGRPFWGWLSDKIGRKNTlSIAFLIQGVAMFLLPFIGSVAVLFVLGVAL-IGFCYGGGFALFPALTADFFGTKNA 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15597310 361 GSGQGFCYNAgRAIAALFPMLIGmlgqklSLGLGIGAFAAVSYGVVILAALSL 413
Cdd:cd17353 338 GTNYGLLYTA-KGVGGLIGPIIA------AYVLYTGGYNAAFIIAAALSLVAL 383
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
64-190 |
9.39e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 44.53 E-value: 9.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 64 AGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFgFGGEWTAGAVLIGEV 143
Cdd:PRK09874 56 SGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNANALIATQ 134
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 15597310 144 IKARDRGKAVGLVQSGWAIGwgltAILYSLMFSLLPPEEAWRALFML 190
Cdd:PRK09874 135 VPRNKSGWALGTLSTGGVSG----ALLGPLAGGLLADSYGLRPVFFI 177
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
73-200 |
1.10e-04 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 44.16 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 73 LASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKA 152
Cdd:cd17361 62 LAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGAL 141
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 15597310 153 VGLVQSGWAIGWgLTAILYSLMFSLLPPeEAWRALFMLGLLPALFVLV 200
Cdd:cd17361 142 NIGFQLAITIGI-LIANLINYGTSKIKP-NGWRLSLGLAAVPALILLL 187
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
53-200 |
1.13e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.13 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 53 LIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYE--QLLVARTLMGFGFG 130
Cdd:cd17316 204 LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSptLLLLLLFILSFFVG 283
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 131 GEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEEAWRALFMLGLLPALFVLV 200
Cdd:cd17316 284 GVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
65-422 |
1.66e-04 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 43.91 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 65 GFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFafftFLCGLAQNYEQLLVA----------------RTLMGFG 128
Cdd:PRK10077 58 GFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLF----FISALGSAWPEFGFTsigpdntgyvpefviyRIIGGIG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 129 FGGEWTAGAVLIGEVIKARDRGKAVGLVQsgWAIGWGLTAILYSLMFSLLPP------EEAWRALFMLGLLPALFVLVVR 202
Cdd:PRK10077 134 VGLASMLSPMYIAEIAPAHIRGKLVSFNQ--FAIIFGQLVVYFVNYFIARSGdaswlnTDGWRYMFASEAIPALLFLMLL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 203 RLVKEPEIYREARQRNQGA--------DKVSFYEIFAPGMLSITLRAS----LLTTGALG--------------GYYAIT 256
Cdd:PRK10077 212 YFVPETPRYLMSRGKQEQAegilrkimGNTLATQALQEIKHSLDHGRKtggkLLMFGVGVivigvmlsvfqqfvGINVVL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 257 AWLPTFLKTergLTVLGTSGYLAMVILG--SYVGYVVSAFLTDLIGRKKNFVL----FAVGSFTV-VLLYTQLPvSNGAM 329
Cdd:PRK10077 292 YYAPEIFKT---LGASTDIALLQTIIVGviNLTFTVLAIMTVDKFGRKPLQIIgalgMAIGMFSLgTAFYTQAP-GIVAL 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 330 LWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSGQ----GFCYNAGRAIAALFPMLIGMLGQKLSLGLGigaFAAVSYGV 405
Cdd:PRK10077 368 LSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKALaiavAAQWIANYFVSWTFPMMDKNSWLVAHFHNG---FSYWIYGC 444
|
410 420
....*....|....*....|..
gi 15597310 406 V-ILAALSL----PETRGKQLE 422
Cdd:PRK10077 445 MgVLAALFMwkfvPETKGKTLE 466
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
41-163 |
2.28e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.02 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 41 MDTQMLSFVIPTLIALW----GIGTGEAGFIHTMTLLASAAGGWIA----GILSDRIGRVLTLQLTVLWFAFFTFLCGLA 112
Cdd:cd17391 211 FIIQLANQSIEPILTLYirqlMGDASNLAFISGLVFSATGVSSLLSaprlGKLGDRIGHHRILLGALLASALLYIPQAFV 290
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 15597310 113 QNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIG 163
Cdd:cd17391 291 QTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLG 341
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
40-201 |
2.80e-04 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 42.87 E-value: 2.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 40 GMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLL 119
Cdd:cd17436 14 GYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSFFWLV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 120 VARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGwglTAILYSLMFSLLPPEEAWRALFMLGLLPALFVL 199
Cdd:cd17436 94 IGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVG---ILISYALNYFFSNVLTGWRYMFGLAIIPAAIQF 170
|
..
gi 15597310 200 VV 201
Cdd:cd17436 171 AS 172
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
81-348 |
3.38e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 42.63 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 81 IAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKArdrGKAVGLVQSGW 160
Cdd:cd17476 52 IFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPP---GPRKNIVFSLF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 161 AIGWGLTAILYSLMFSLLPPEEAWRALFMLGLLPALFVLVVRRLVKEPEIyrearqrnqgadkvsfyeifapgmlsitlR 240
Cdd:cd17476 129 GATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFWTSPSF-----------------------------I 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 241 ASLLTTGALGGYYAITAWLPT-FLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIgRKKNFVLFAVGSFTV-VLL 318
Cdd:cd17476 180 AVLLAVFLGWASFGIWVFYATqYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARL-PPSYIMAISMVAFLVgPIL 258
|
250 260 270
....*....|....*....|....*....|
gi 15597310 319 YTQLPVSNGAMLWlgfplgFFASGIFSGMG 348
Cdd:cd17476 259 FATMPVHQTYWAQ------AFPAMIVAPFG 282
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
68-130 |
7.36e-04 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 41.46 E-value: 7.36e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597310 68 HTMT--LLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFG 130
Cdd:PRK15402 52 TSMTayLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLC 116
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
243-417 |
1.04e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.11 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 243 LLTTGALGGYYAITAWLPTF--LKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTVVLLYT 320
Cdd:COG2814 14 ALALGAFLSGLGIGIVLPALplIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 321 QLPvSNGAMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIGAFAA 400
Cdd:COG2814 94 LAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV 172
|
170
....*....|....*..
gi 15597310 401 VSYGVVILAALSLPETR 417
Cdd:COG2814 173 LALLALLLLLRLLPESR 189
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
58-385 |
1.29e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 40.61 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 58 GIGTGEAGFIHTMTLLASAAGGWIAGILSDRIG-RVLTLQLTVLWFAFFtFLCGLAQNYEQLLVARTLM-GFGFGGEWTA 135
Cdd:cd17352 34 GESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGcRPVAIAGGLLAALGL-LLSSFATSLWQLYLTYGVLgGLGLGLIYSP 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 136 GAVLIGEVIKARdRGKAVGLVQSGWAIGwgltAILYSLMFSLLPPEEAWR-ALFMLG--LLPALFVLVVRRLVKEPeiyr 212
Cdd:cd17352 113 AIVIVGQYFEKK-RGLATGIAVAGSGVG----TFVFPPLLRYLLDNYGWRgALLILGglCLNLCVCGLLLRLLKDP---- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 213 earqrnqgadkvsFYEIFAPGMLSITLrasllttgalgGYYAITAWLPTFLKtERGLTVLGTSGYLAMVILGSYVGYVVS 292
Cdd:cd17352 184 -------------TFVLLALGVSFAML-----------GFFVPFVYLPSYAK-SLGIDESDAAFLLSIIGISDIVGRILL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 293 AFLTDLIG-RKKNFVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAG 371
Cdd:cd17352 239 GLLADKPRiGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQ 318
|
330
....*....|....
gi 15597310 372 RAIAALFPMLIGML 385
Cdd:cd17352 319 GLAALVGPPIAGLL 332
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
50-409 |
2.71e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.55 E-value: 2.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 50 IPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGF 129
Cdd:cd17393 22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 130 GGEWTAGAVLIGEVIKARDRGKAVGLvQSGWAIGWGLTAILYSLMFSLLPPeeAWRALFMLGLLPALFVLVVRRLVKEPE 209
Cdd:cd17393 102 GALDVAMNAQGVAVERAYGRPIMSSL-HAMWSLGGLAGALLGAAAIGAGVS--PGVHLLAAAVLLLLAALVAIRALLPGT 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 210 IYREARQRNQGADKVSFYEIFAPGMLSITLRASLLTTGalggyyAITAWLPTFLKTERGLTV-LGTSGYLAMVIlGSYVG 288
Cdd:cd17393 179 GEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEG------AAADWSALYLRDVLGASAaLAALGYAVFSL-AMTVG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 289 YVVSAFLTDLIGRKKnfVLFAVGSFTVVLLYTQLPVSNGAMLWLGFPLgffasgifsgMGSFLTELFPTRIRGSGQGFCY 368
Cdd:cd17393 252 RLFGDRLVDRFGDVA--VLRAGALLAALGLLLALLAPSVWVALAGFAL----------MGLGLSVVVPLAFSAAGALPGL 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 15597310 369 NAGRAIAALF----------PMLIGMLGQKLSLGLGIGAFAAVSYGVVILA 409
Cdd:cd17393 320 AAGIAVARVAtlgylgflvgPPLIGFLADATGLRTAFLVVALLALLVALLA 370
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
243-416 |
2.75e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.86 E-value: 2.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 243 LLTTGALGGYYAITAW--LPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVgSFTVVLLYT 320
Cdd:COG2223 9 LATLAFFLAFGVWYLWsvLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLL-LLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 321 QLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQKLSLGLGIGAFAA 400
Cdd:COG2223 88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
|
170
....*....|....*.
gi 15597310 401 VSYGVVILAALSLPET 416
Cdd:COG2223 168 LLLVVAVLAWLFLRDP 183
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
26-201 |
6.75e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.41 E-value: 6.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 26 RRAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIGRVLTLQLTVLWFAFF 105
Cdd:cd17355 209 SASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALG 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 106 TFLCGLAQN-YEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPP-EEA 183
Cdd:cd17355 289 LALLLLLPFpPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSyTAA 368
|
170
....*....|....*...
gi 15597310 184 WRALFMLGLLPALFVLVV 201
Cdd:cd17355 369 WALAVALGLIAALLVLPI 386
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
83-413 |
7.53e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 7.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 83 GILSDRIG-RVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGfGGEWTAGAVLIGEVIKARDRGKAVGLVQSGWA 161
Cdd:cd17490 52 GILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLINLVNN 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 162 IGWGLTAILYSLMFSLLppeeAWRALFMLGLLPALFVLVVRRLVKEPEiyREARQRNQGADKVsfyeifapgmLSITLRA 241
Cdd:cd17490 131 LGQLIAFLIGGLIAEHF----GMRAPFLLAALAGVLGFILSLFIKEER--REKKPVLTELKEL----------LSVLKDK 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 242 SLLTTGALGGYYAITAWLPTFLKTERGLTVLGTSG---------YLAMVILGSYVGYvvSAFLTDLIGRKKNFVLFAVGS 312
Cdd:cd17490 195 KLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSfqlgllsiiYLLPNALASLLSG--TLFYKKLGERNTIIIGFLLLG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597310 313 FTVVLLYTqlpVSNGAMLWLGFPLGFFASGI-FSGMGSFLTELFPTRIRGSGQGFcYNAGRAIA-ALFPMLIGMLGQKLS 390
Cdd:cd17490 273 AYCFLIPF---APNLTLLYLLQALNGFGTGIlFPLLMSLSIEGVPAEQRSTAMGF-FQAIYALGmFLGPVLVGIISEAFG 348
|
330 340
....*....|....*....|...
gi 15597310 391 LGLGIGAFAAVSYGVVILAALSL 413
Cdd:cd17490 349 LQTGFFVIGVIALLAAILSLAYY 371
|
|
| |
