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Conserved domains on  [gi|15597473|ref|NP_250967|]
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ArsR family transcriptional regulator [Pseudomonas aeruginosa PAO1]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 229396)

helix-turn-helix domain-containing protein may bind DNA and be involved in the regulation of gene expression

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_CRP super family cl46859
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 1-101 5.42e-34

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


The actual alignment was detected with superfamily member PRK10141:

Pssm-ID: 481199  Cd Length: 117  Bit Score: 113.76  E-value: 5.42e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597473    1 MPSPAEVFKCLADETRVRATLLIVDQGELCVCELMCALADSQPKISRHLAQLRSAGLLLDRRQGQWVYYRLNPALPAWIH 80
Cdd:PRK10141   3 FLLPLQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWAA 82

                         90       100
                 ....*....|....*....|.
gi 15597473   81 EVLQVTLRANGDWLQADAARL 101
Cdd:PRK10141  83 KIIEQAWLCEQEDVQAIVRNL 103
 
Name Accession Description Interval E-value
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 1-101 5.42e-34

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 113.76  E-value: 5.42e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597473    1 MPSPAEVFKCLADETRVRATLLIVDQGELCVCELMCALADSQPKISRHLAQLRSAGLLLDRRQGQWVYYRLNPALPAWIH 80
Cdd:PRK10141   3 FLLPLQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWAA 82

                         90       100
                 ....*....|....*....|.
gi 15597473   81 EVLQVTLRANGDWLQADAARL 101
Cdd:PRK10141  83 KIIEQAWLCEQEDVQAIVRNL 103
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 5-79 8.56e-28

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 96.76  E-value: 8.56e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597473    5 AEVFKCLADETRVRATLLIVdQGELCVCELMCALADSQPKISRHLAQLRSAGLLLDRRQGQWVYYRLNPALPAWI 79
Cdd:NF033788   2 AELFKALADPTRLRILELLA-EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
5-83 5.39e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 90.33  E-value: 5.39e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597473   5 AEVFKCLADETRVRATLLIVdQGELCVCELMCALADSQPKISRHLAQLRSAGLLLDRRQGQWVYYRLNPALPAWIHEVL 83
Cdd:COG0640  11 AELFKALADPTRLRILRLLA-EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWL 88
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 8-84 1.21e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 73.49  E-value: 1.21e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597473   8 FKCLADETRVRATLLIVDqGELCVCELMCALADSQPKISRHLAQLRSAGLLLDRRQGQWVYYRLNPA--LPAWIHEVLQ 84
Cdd:cd00090   1 LKALSDPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAerLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
26-83 3.89e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 71.86  E-value: 3.89e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 15597473     26 QGELCVCELMCALADSQPKISRHLAQLRSAGLLLDRRQGQWVYYRLNP-ALPAWIHEVL 83
Cdd:smart00418   8 EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDeKVADLLEELL 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 13-58 6.80e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 55.53  E-value: 6.80e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15597473    13 DETRVRAtLLIVDQGELCVCELMCALADSQPKISRHLAQLRSAGLL 58
Cdd:pfam01022   1 DPTRLKI-LKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
 
Name Accession Description Interval E-value
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 1-101 5.42e-34

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 113.76  E-value: 5.42e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597473    1 MPSPAEVFKCLADETRVRATLLIVDQGELCVCELMCALADSQPKISRHLAQLRSAGLLLDRRQGQWVYYRLNPALPAWIH 80
Cdd:PRK10141   3 FLLPLQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWAA 82

                         90       100
                 ....*....|....*....|.
gi 15597473   81 EVLQVTLRANGDWLQADAARL 101
Cdd:PRK10141  83 KIIEQAWLCEQEDVQAIVRNL 103
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 5-79 8.56e-28

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 96.76  E-value: 8.56e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597473    5 AEVFKCLADETRVRATLLIVdQGELCVCELMCALADSQPKISRHLAQLRSAGLLLDRRQGQWVYYRLNPALPAWI 79
Cdd:NF033788   2 AELFKALADPTRLRILELLA-EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
5-83 5.39e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 90.33  E-value: 5.39e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597473   5 AEVFKCLADETRVRATLLIVdQGELCVCELMCALADSQPKISRHLAQLRSAGLLLDRRQGQWVYYRLNPALPAWIHEVL 83
Cdd:COG0640  11 AELFKALADPTRLRILRLLA-EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWL 88
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 8-84 1.21e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 73.49  E-value: 1.21e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597473   8 FKCLADETRVRATLLIVDqGELCVCELMCALADSQPKISRHLAQLRSAGLLLDRRQGQWVYYRLNPA--LPAWIHEVLQ 84
Cdd:cd00090   1 LKALSDPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAerLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
26-83 3.89e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 71.86  E-value: 3.89e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 15597473     26 QGELCVCELMCALADSQPKISRHLAQLRSAGLLLDRRQGQWVYYRLNP-ALPAWIHEVL 83
Cdd:smart00418   8 EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDeKVADLLEELL 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 13-58 6.80e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 55.53  E-value: 6.80e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15597473    13 DETRVRAtLLIVDQGELCVCELMCALADSQPKISRHLAQLRSAGLL 58
Cdd:pfam01022   1 DPTRLKI-LKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 5-65 2.69e-06

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 41.37  E-value: 2.69e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597473     5 AEVFKCLADETRVRATLLIVDQGELCVCELMCALADSQPKISRHLAQLRSAGLLLDRRQGQ 65
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
4-101 1.07e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 41.17  E-value: 1.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597473   4 PAEVFKCLADETRvRATLLIVDQGELCVCELMCALADSQPKISRHLAQLRSAGLL-----LDRRQGQWVYYRLNPAL--- 75
Cdd:COG1777   7 LDRLLDALGNPTR-RRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVesyreGREDGRARKYYRLSAFRlev 85

                        90       100
                ....*....|....*....|....*....
gi 15597473  76 ---PAWIHEVLQvTLRANGDWLQADAARL 101
Cdd:COG1777  86 tltPDLFARLAR-ELEAYRRELSGRLARI 113
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
5-58 4.25e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 36.48  E-value: 4.25e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 15597473   5 AEVFKCLADETRVRaTLLIVDQGELCVCELMCALADSQPKISRHLAQLRSAGLL 58
Cdd:COG4189  10 LEVLKALASETRLR-ILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLI 62
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
37-73 9.78e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 33.70  E-value: 9.78e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15597473  37 ALAD----SQPKISRHLAQLRSAGLLLDRRQGQWVYYRLNP 73
Cdd:COG3398 116 ELAEelgiSRSTVSWHLKRLEEDGLVERERDGRNVRYYLNP 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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