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Conserved domains on  [gi|15597694|ref|NP_251188|]
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hypothetical protein PA2498 [Pseudomonas aeruginosa PAO1]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-209 1.15e-39

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.39  E-value: 1.15e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   5 AAFSGGAGASDAGALLEAARRGDTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSP 84
Cdd:COG0666  44 LLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETP 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  85 YLLAGAEGRLEILRLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLEAILLsdggpRH 164
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN-----GH 198

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 15597694 165 QEIVRLLIDAGADVNLADADGVSPLAHARQRGQGGIERLLLAAGA 209
Cdd:COG0666 199 LEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA 243
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-209 1.15e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.39  E-value: 1.15e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   5 AAFSGGAGASDAGALLEAARRGDTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSP 84
Cdd:COG0666  44 LLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETP 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  85 YLLAGAEGRLEILRLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLEAILLsdggpRH 164
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN-----GH 198

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 15597694 165 QEIVRLLIDAGADVNLADADGVSPLAHARQRGQGGIERLLLAAGA 209
Cdd:COG0666 199 LEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA 243
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 19-180 9.40e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 80.42  E-value: 9.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   19 LLEAARRGDTAQVASLLE-RKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEIL 97
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDlGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   98 RLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLeAILLSDGGPrhqEIVRLLIDAGAD 177
Cdd:PHA02875 152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAAL-CYAIENNKI---DIVRLFIKRGAD 227


                 ...
gi 15597694  178 VNL 180
Cdd:PHA02875 228 CNI 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
87-182 3.82e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.44  E-value: 3.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694    87 LAGAEGRLEILRLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQaGVDPNHVNKlGWTGLLEAILLsdggpRHQE 166
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARS-----GHLE 75

                          90
                  ....*....|....*.
gi 15597694   167 IVRLLIDAGADVNLAD 182
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 77-209 9.54e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.39  E-value: 9.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  77 QNSRL-DSPYLLAGAEGRLE-ILRLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQAgvDPNHVNK-------LG 147
Cdd:cd22192  12 QQKRIsESPLLLAAKENDVQaIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEA--APELVNEpmtsdlyQG 89

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597694 148 WTGLLEAILLSDggprhQEIVRLLIDAGADVNLADADGV--------------SPLAHARQRGQGGIERLLLAAGA 209
Cdd:cd22192  90 ETALHIAVVNQN-----LNLVRELIARGADVVSPRATGTffrpgpknliyygeHPLSFAACVGNEEIVRLLIEHGA 160
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 47-75 1.30e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.30e-03
                           10        20
                   ....*....|....*....|....*....
gi 15597694     47 DGSTPLLLATANDHLAVARQLIEAGADVN 75
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-209 1.15e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.39  E-value: 1.15e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   5 AAFSGGAGASDAGALLEAARRGDTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSP 84
Cdd:COG0666  44 LLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETP 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  85 YLLAGAEGRLEILRLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLEAILLsdggpRH 164
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN-----GH 198

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 15597694 165 QEIVRLLIDAGADVNLADADGVSPLAHARQRGQGGIERLLLAAGA 209
Cdd:COG0666 199 LEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-209 6.23e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.77  E-value: 6.23e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   5 AAFSGGAGASDAGALLEAARRGDTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSP 84
Cdd:COG0666  77 GADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  85 YLLAGAEGRLEILRLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLEAILLsdggpRH 164
Cdd:COG0666 157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAEN-----GN 231

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 15597694 165 QEIVRLLIDAGADVNLADADGVSPLAHARQRGQGGIERLLLAAGA 209
Cdd:COG0666 232 LEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-209 2.07e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 115.82  E-value: 2.07e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  19 LLEAARRGDTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILR 98
Cdd:COG0666  25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  99 LTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLEAILLsdggpRHQEIVRLLIDAGADV 178
Cdd:COG0666 105 LLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN-----GNLEIVKLLLEAGADV 179

                       170       180       190
                ....*....|....*....|....*....|.
gi 15597694 179 NLADADGVSPLAHARQRGQGGIERLLLAAGA 209
Cdd:COG0666 180 NARDNDGETPLHLAAENGHLEIVKLLLEAGA 210
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-185 2.05e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 100.03  E-value: 2.05e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  19 LLEAARRGDTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILR 98
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVK 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  99 LTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLEAILLsdggpRHQEIVRLLIDAGADV 178
Cdd:COG0666 204 LLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA-----GAALIVKLLLLALLLL 278


                ....*..
gi 15597694 179 NLADADG 185
Cdd:COG0666 279 AAALLDL 285
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-209 9.23e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.09  E-value: 9.23e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  31 VASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILRLTLLHGADLKST 110
Cdd:COG0666   4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694 111 NRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLEAILLsdggpRHQEIVRLLIDAGADVNLADADGVSPLA 190
Cdd:COG0666  84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN-----GNLEIVKLLLEAGADVNAQDNDGNTPLH 158

                       170
                ....*....|....*....
gi 15597694 191 HARQRGQGGIERLLLAAGA 209
Cdd:COG0666 159 LAAANGNLEIVKLLLEAGA 177
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 19-180 9.40e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 80.42  E-value: 9.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   19 LLEAARRGDTAQVASLLE-RKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEIL 97
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDlGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   98 RLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLeAILLSDGGPrhqEIVRLLIDAGAD 177
Cdd:PHA02875 152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAAL-CYAIENNKI---DIVRLFIKRGAD 227


                 ...
gi 15597694  178 VNL 180
Cdd:PHA02875 228 CNI 230
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-151 2.10e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.46  E-value: 2.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  19 LLEAARRGDTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILR 98
Cdd:COG0666 157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVK 236

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 15597694  99 LTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGL 151
Cdd:COG0666 237 LLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 34-179 2.25e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.55  E-value: 2.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   34 LLERKVEVDAPSADGSTPLLLATAN--DHLAVARQLIEAGADVNRQNSRLDSP--YLLAGAEGRLEILRLTLLHGADLKS 109
Cdd:PHA03100  92 LLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLlhLYLESNKIDLKILKLLIDKGVDINA 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  110 TNR----------------YGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLEAILlsdggPRHQEIVRLLID 173
Cdd:PHA03100 172 KNRvnyllsygvpinikdvYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIL-----NNNKEIFKLLLN 246


                 ....*.
gi 15597694  174 AGADVN 179
Cdd:PHA03100 247 NGPSIK 252
PHA03095 PHA03095
ankyrin-like protein; Provisional
 53-209 2.97e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.52  E-value: 2.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   53 LLATANDHLAVARQLIEAGADVNRQNSRLDSP---YLLAGAEGRLEILRLTLLHGADLKSTNRYGGTALIP-ACERGHVE 128
Cdd:PHA03095  19 LLNASNVTVEEVRRLLAAGADVNFRGEYGKTPlhlYLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLyLYNATTLD 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  129 VVKTLLQAGVDPNHVNKLGWTgLLEAILlsdGGPR-HQEIVRLLIDAGADVNLADADGVSPLAHARQRGQGGIE--RLLL 205
Cdd:PHA03095  99 VIKLLIKAGADVNAKDKVGRT-PLHVYL---SGFNiNPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVEllRLLI 174


                 ....
gi 15597694  206 AAGA 209
Cdd:PHA03095 175 DAGA 178
PHA03095 PHA03095
ankyrin-like protein; Provisional
 31-206 1.01e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.90  E-value: 1.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   31 VASLLERKVEVDAPSADGSTPL--LLATANDHLAVARQLIEAGADVNRQNSRLDSP--YLLAGAEGRLEILRLTLLHGAD 106
Cdd:PHA03095 135 IRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGADVYAVDDRFRSLlhHHLQSFKPRARIVRELIRAGCD 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  107 LKSTNRYGGTAL-----IPACERGHVEvvkTLLQAGVDPNHVNKLGWTGLLEAillsdGGPRHQEIVRLLIDAGADVNLA 181
Cdd:PHA03095 215 PAATDMLGNTPLhsmatGSSCKRSLVL---PLLIAGISINARNRYGQTPLHYA-----AVFNNPRACRRLIALGADINAV 286

                        170       180
                 ....*....|....*....|....*
gi 15597694  182 DADGVSPLAHARQRGQGGIERLLLA 206
Cdd:PHA03095 287 SSDGNTPLSLMVRNNNGRAVRAALA 311
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 26-209 1.76e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 68.07  E-value: 1.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   26 GDTAQVASLLERKVEVDAPSADGS-TPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILRLTLLHG 104
Cdd:PHA02874  12 GDIEAIEKIIKNKGNCINISVDETtTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  105 ADlkstnryggTALIPACERGHvEVVKTLLQAGVDPNHVNKLGWTGLLEAILLSDggprhQEIVRLLIDAGADVNLADAD 184
Cdd:PHA02874  92 VD---------TSILPIPCIEK-DMIKTILDCGIDVNIKDAELKTFLHYAIKKGD-----LESIKMLFEYGADVNIEDDN 156

                        170       180
                 ....*....|....*....|....*
gi 15597694  185 GVSPLAHARQRGQGGIERLLLAAGA 209
Cdd:PHA02874 157 GCYPIHIAIKHNFFDIIKLLLEKGA 181
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 31-209 2.37e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 68.17  E-value: 2.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   31 VASLLERKVEVDAPSADGSTPLLLATANDH-LAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILRLTLLH-GADLK 108
Cdd:PHA02876 290 VPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLElGANVN 369

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  109 STNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLEAILlsdgGPRHQEIVRLLIDAGADVNLADADGVSP 188
Cdd:PHA02876 370 ARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALC----GTNPYMSVKTLIDRGANVNSKNKDLSTP 445

                        170       180
                 ....*....|....*....|..
gi 15597694  189 LAHA-RQRGQGGIERLLLAAGA 209
Cdd:PHA02876 446 LHYAcKKNCKLDVIEMLLDNGA 467
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 31-194 2.41e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 67.68  E-value: 2.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   31 VASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILRLTLLHGADLKST 110
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  111 NRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLEAILlsdggpRHQEIVRLLIDaGADVNLADADGVSPLA 190
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII------HNRSAIELLIN-NASINDQDIDGSTPLH 259


                 ....
gi 15597694  191 HARQ 194
Cdd:PHA02874 260 HAIN 263
Ank_2 pfam12796
Ankyrin repeats (3 copies);
87-182 3.82e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.44  E-value: 3.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694    87 LAGAEGRLEILRLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQaGVDPNHVNKlGWTGLLEAILLsdggpRHQE 166
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARS-----GHLE 75

                          90
                  ....*....|....*.
gi 15597694   167 IVRLLIDAGADVNLAD 182
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 31-189 1.28e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.73  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   31 VASLLERKVEVDAPSADGSTPL-LLATANDHLAVARQLIEAGADVNRQNSRLDSP---YlLAGAEGRLEILRLTLLHGAD 106
Cdd:PHA03095  66 VRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPlhvY-LSGFNINPKVIRLLLRKGAD 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  107 LKSTNRYGGTALipAC----ERGHVEVVKTLLQAGVDPNHVNKLGWTgLLEAILLSdggPR-HQEIVRLLIDAGADVNLA 181
Cdd:PHA03095 145 VNALDLYGMTPL--AVllksRNANVELLRLLIDAGADVYAVDDRFRS-LLHHHLQS---FKpRARIVRELIRAGCDPAAT 218


                 ....*...
gi 15597694  182 DADGVSPL 189
Cdd:PHA03095 219 DMLGNTPL 226
Ank_2 pfam12796
Ankyrin repeats (3 copies);
19-144 1.74e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.20  E-value: 1.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694    19 LLEAARRGDTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEaGADVNRQNsrldspyllagaegrleilr 98
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-------------------- 59

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 15597694    99 ltllhgadlkstnrYGGTALIPACERGHVEVVKTLLQAGVDPNHVN 144
Cdd:pfam12796  60 --------------NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
121-209 3.53e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.43  E-value: 3.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   121 ACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLEAILLsdggpRHQEIVRLLIDaGADVNLADaDGVSPLAHARQRGQGGI 200
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKN-----GHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEI 76


                  ....*....
gi 15597694   201 ERLLLAAGA 209
Cdd:pfam12796  77 VKLLLEKGA 85
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 27-192 3.98e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 61.43  E-value: 3.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   27 DTAQVASLLERKVEVDAPSAD-GSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILRLTLLHGA 105
Cdd:PHA02878 146 EAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  106 DLKSTNRYGGTAL-IPACERGHVEVVKTLLQAGVDPNHVNK-LGWTGLLEAIllsdggpRHQEIVRLLIDAGADVNLADA 183
Cdd:PHA02878 226 STDARDKCGNTPLhISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI-------KSERKLKLLLEYGADINSLNS 298


                 ....*....
gi 15597694  184 DGVSPLAHA 192
Cdd:PHA02878 299 YKLTPLSSA 307
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 19-184 6.62e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 61.04  E-value: 6.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   19 LLEAARRGDTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILR 98
Cdd:PLN03192 529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   99 LtLLHGADLkSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLleAILLSDGgprHQEIVRLLIDAGADV 178
Cdd:PLN03192 609 I-LYHFASI-SDPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATAL--QVAMAED---HVDMVRLLIMNGADV 681


                 ....*.
gi 15597694  179 NLADAD 184
Cdd:PLN03192 682 DKANTD 687
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 23-210 3.58e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.92  E-value: 3.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   23 ARRG-DTAQVASLLERKVEVDAPSADGSTPLLLATANDHLA-VARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILRLT 100
Cdd:PHA02876 315 AKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTL 394

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  101 LLHGADLKSTNRYGGTAL-IPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLEAIlLSDGGPrhqEIVRLLIDAGADVN 179
Cdd:PHA02876 395 LDYGADIEALSQKIGTALhFALCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYAC-KKNCKL---DVIEMLLDNGADVN 470

                        170       180       190
                 ....*....|....*....|....*....|.
gi 15597694  180 LADADGVSPLAHArqRGQGGIERLLLAAGAQ 210
Cdd:PHA02876 471 AINIQNQYPLLIA--LEYHGIVNILLHYGAE 499
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 31-192 1.13e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.98  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   31 VASLLERKVEVDAPSADGSTPLLLATANDH-----LAVARQLIEAGADVNRQNSRLDSP--YLLAGAEGRLEILRLTLLH 103
Cdd:PHA03100  51 VKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPllYAISKKSNSYSIVEYLLDN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  104 GADLKSTNRYGGTALIPACERGHV--EVVKTLLQAGVDPNHVNKlgwtglleaillsdggprhqeiVRLLIDAGADVNLA 181
Cdd:PHA03100 131 GANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINAKNR----------------------VNYLLSYGVPINIK 188

                        170
                 ....*....|.
gi 15597694  182 DADGVSPLAHA 192
Cdd:PHA03100 189 DVYGFTPLHYA 199
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 19-103 3.66e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 55.67  E-value: 3.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   19 LLEAARRGDTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILR 98
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165


                 ....*
gi 15597694   99 LTLLH 103
Cdd:PTZ00322 166 LLSRH 170
PHA02798 PHA02798
ankyrin-like protein; Provisional
 40-151 5.00e-09

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 55.23  E-value: 5.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   40 EVDAPSADGSTPL--LLATANDH---LAVARQLIEAGADVNRQNSRLDSP---YLLAGAEGRLEILRLTLLHGADLKSTN 111
Cdd:PHA02798  63 NVNGLDNEYSTPLctILSNIKDYkhmLDIVKILIENGADINKKNSDGETPlycLLSNGYINNLEILLFMIENGADTTLLD 142

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 15597694  112 RYGGTALIPACERGH---VEVVKTLLQAGVDPN-HVNKLGWTGL 151
Cdd:PHA02798 143 KDGFTMLQVYLQSNHhidIEIIKLLLEKGVDINtHNNKEKYDTL 186
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 22-210 8.39e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.68  E-value: 8.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   22 AARRGDTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNR---------QNSRLDSPYLLAGAE- 91
Cdd:PHA02876 185 AAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKndlsllkaiRNEDLETSLLLYDAGf 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   92 --GRLEILRLTLLH------------------GADLKSTNRYGGTALIPACERGH-VEVVKTLLQAGVDPNHVNKLGWTG 150
Cdd:PHA02876 265 svNSIDDCKNTPLHhasqapslsrlvpkllerGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITP 344

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  151 LLEAILLSdggpRHQEIVRLLIDAGADVNLADADGVSPLAHARQRGQGGIERLLLAAGAQ 210
Cdd:PHA02876 345 LHQASTLD----RNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 47-209 5.52e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.92  E-value: 5.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   47 DGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILRLTLLHGADLKST-NRYGGTALIPACERG 125
Cdd:PHA02875  34 DGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVfYKDGMTPLHLATILK 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  126 HVEVVKTLLQAGVDPNHVNKLGWTGLLEAILLSDggprhQEIVRLLIDAGADVNLADADGVSPLAHARQRGQGGIERLLL 205
Cdd:PHA02875 114 KLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGD-----IKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLL 188


                 ....
gi 15597694  206 AAGA 209
Cdd:PHA02875 189 DSGA 192
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 59-194 1.33e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.22  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   59 DHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILRLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQagv 138
Cdd:PHA02876 156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID--- 232

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15597694  139 DPNHVNKLGWTgLLEAILLSDggprhQEIVRLLIDAGADVNLADADGVSPLAHARQ 194
Cdd:PHA02876 233 NRSNINKNDLS-LLKAIRNED-----LETSLLLYDAGFSVNSIDDCKNTPLHHASQ 282
PHA03095 PHA03095
ankyrin-like protein; Provisional
 85-209 2.45e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 2.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   85 YLLAGAEGRLEILRLTLLHGADLKSTNRYGGTALipaCERGH------VEVVKTLLQAGVDPNHVNKLGWTGLLEAILLS 158
Cdd:PHA03095  18 YLLNASNVTVEEVRRLLAAGADVNFRGEYGKTPL---HLYLHyssekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNA 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15597694  159 DggprHQEIVRLLIDAGADVNLADADGVSPLaHARQRGQG---GIERLLLAAGA 209
Cdd:PHA03095  95 T----TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGFNinpKVIRLLLRKGA 143
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 22-189 3.82e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.58  E-value: 3.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   22 AARRGDTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILRLTL 101
Cdd:PHA02874 131 AIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  102 LHGADLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNklGWTGLLEAIllsdGGPRHQEIVRLLIDAGADVNLA 181
Cdd:PHA02874 211 DHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINNASINDQDID--GSTPLHHAI----NPPCDIDIIDILLYHKADISIK 284


                 ....*...
gi 15597694  182 DADGVSPL 189
Cdd:PHA02874 285 DNKGENPI 292
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 31-113 4.56e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 49.28  E-value: 4.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   31 VASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILRLTLLHGADLKST 110
Cdd:PHA03100 175 VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTI 254


                 ...
gi 15597694  111 NRY 113
Cdd:PHA03100 255 IET 257
Ank_4 pfam13637
Ankyrin repeats (many copies);
83-134 1.82e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 1.82e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15597694    83 SPYLLAGAEGRLEILRLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLL 134
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 93-189 2.16e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 47.35  E-value: 2.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   93 RLEILRLTLLHGADLKSTNRYGGTALIPACERGHV-----EVVKTLLQAGVDPNHVNKLGWTGLLEAILLSDGgprHQEI 167
Cdd:PHA03100  47 NIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISKKSN---SYSI 123

                         90       100
                 ....*....|....*....|..
gi 15597694  168 VRLLIDAGADVNLADADGVSPL 189
Cdd:PHA03100 124 VEYLLDNGANVNIKNSDGENLL 145
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 130-205 3.47e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.82  E-value: 3.47e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597694  130 VKTLLQAGVDPNHVNKLGWTGLLEAILLSdggprHQEIVRLLIDAGADVNLADADGVSPLAHARQRGQGGIERLLL 205
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANG-----HVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 50-196 4.14e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 45.58  E-value: 4.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   50 TPLLLATANDH--LAVARQLIEAGADVN----RQNSRLDSPYLLAGAEGRLEILRLTLLHGADLKSTNRYGGTAL---IP 120
Cdd:PHA02859  53 TPIFSCLEKDKvnVEILKFLIENGADVNfktrDNNLSALHHYLSFNKNVEPEILKILIDSGSSITEEDEDGKNLLhmyMC 132

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597694  121 ACERgHVEVVKTLLQAGVDPNHVNKLGWTGLLEAILLSDggprHQEIVRLLIDAGADVNLADADGVSPLAHARQRG 196
Cdd:PHA02859 133 NFNV-RINVIKLLIDSGVSFLNKDFDNNNILYSYILFHS----DKKIFDFLTSLGIDINETNKSGYNCYDLIKFRN 203
Ank_4 pfam13637
Ankyrin repeats (many copies);
114-172 4.53e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 4.53e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15597694   114 GGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLEAILlsdGGprHQEIVRLLI 172
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAAS---NG--NVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 77-209 9.54e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.39  E-value: 9.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  77 QNSRL-DSPYLLAGAEGRLE-ILRLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQAgvDPNHVNK-------LG 147
Cdd:cd22192  12 QQKRIsESPLLLAAKENDVQaIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEA--APELVNEpmtsdlyQG 89

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597694 148 WTGLLEAILLSDggprhQEIVRLLIDAGADVNLADADGV--------------SPLAHARQRGQGGIERLLLAAGA 209
Cdd:cd22192  90 ETALHIAVVNQN-----LNLVRELIARGADVVSPRATGTffrpgpknliyygeHPLSFAACVGNEEIVRLLIEHGA 160
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 34-145 1.10e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.04  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   34 LLERKVEVDAPSADGSTPLLLATANDH--LAVARQLIEAGADVNRQNS----------------RLDSPYLLAGAEGRLE 95
Cdd:PHA03100 127 LLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAKNRvnyllsygvpinikdvYGFTPLHYAVYNNNPE 206

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 15597694   96 ILRLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNK 145
Cdd:PHA03100 207 FVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 54-134 1.15e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   54 LATANDHLAvARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILRLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTL 133
Cdd:PTZ00322  89 LAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167


                 .
gi 15597694  134 L 134
Cdd:PTZ00322 168 S 168
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 48-118 1.33e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 1.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  48 GSTPLLLATANDHLAVARQLIEAGADVnrQNSRLDSPYLLAGAEGRL----------------EILRLTLLHGADLKSTN 111
Cdd:cd22192  89 GETALHIAVVNQNLNLVRELIARGADV--VSPRATGTFFRPGPKNLIyygehplsfaacvgneEIVRLLIEHGADIRAQD 166


                ....*..
gi 15597694 112 RYGGTAL 118
Cdd:cd22192 167 SLGNTVL 173
PHA02946 PHA02946
ankyin-like protein; Provisional
 27-189 3.59e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 43.89  E-value: 3.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   27 DTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSP-YLLAGAEGR-LEILRLTLLHG 104
Cdd:PHA02946  51 DERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPlYYLSGTDDEvIERINLLVQYG 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  105 ADLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGwTGLLEAILLSDgGPRHQEIvRLLIDAGADVNLADAD 184
Cdd:PHA02946 131 AKINNSVDEEGCGPLLACTDPSERVFKKIMSIGFEARIVDKFG-KNHIHRHLMSD-NPKASTI-SWMMKLGISPSKPDHD 207


                 ....*
gi 15597694  185 GVSPL 189
Cdd:PHA02946 208 GNTPL 212
PHA02798 PHA02798
ankyrin-like protein; Provisional
 33-179 5.52e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 43.28  E-value: 5.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   33 SLLERKVEVDAPSADgstplllatandhlaVARQLIEAGADVNRQNSRLDSPY--LLAGA---EGRLEILRLTLLHGADL 107
Cdd:PHA02798  38 SIFQKYLQRDSPSTD---------------IVKLFINLGANVNGLDNEYSTPLctILSNIkdyKHMLDIVKILIENGADI 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597694  108 KSTNRYGGTALIPACERGHV---EVVKTLLQAGVDPNHVNKLGWTGLleAILLSDGGPRHQEIVRLLIDAGADVN 179
Cdd:PHA02798 103 NKKNSDGETPLYCLLSNGYInnlEILLFMIENGADTTLLDKDGFTML--QVYLQSNHHIDIEIIKLLLEKGVDIN 175
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 22-156 1.30e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.17  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   22 AARRGDTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLIEAGADVNRQNSRLDSPylLAGAEGRL---EILR 98
Cdd:PHA02878 175 ATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTP--LHISVGYCkdyDILK 252

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   99 LTLLHGADL--KSTNRyGGTALIPACERGhvEVVKTLLQAGVDPNHVNKLGWTGLLEAIL 156
Cdd:PHA02878 253 LLLEHGVDVnaKSYIL-GLTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPLSSAVK 309
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 98-186 1.67e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 1.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   98 RLTLLHGADLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWTGLLEAIllsDGGPRhqEIVRLLIDAGAD 177
Cdd:PTZ00322  99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAE---ENGFR--EVVQLLSRHSQC 173


                 ....*....
gi 15597694  178 VNLADADGV 186
Cdd:PTZ00322 174 HFELGANAK 182
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 97-189 1.70e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 41.65  E-value: 1.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   97 LRLTLLHGADLKSTNRyGGTALIPACERGHV--EVVKTLLQAGVDPNHvnklgwTGLLE----AIL----LSDGgpRHQE 166
Cdd:PHA02989  19 LEFLLRTGFDVNEEYR-GNSILLLYLKRKDVkiKIVKLLIDNGADVNY------KGYIEtplcAVLrnreITSN--KIKK 89

                         90       100
                 ....*....|....*....|...
gi 15597694  167 IVRLLIDAGADVNLADADGVSPL 189
Cdd:PHA02989  90 IVKLLLKFGADINLKTFNGVSPI 112
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 19-189 1.86e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.54  E-value: 1.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  19 LLEAARRGDTAQVASLLERK-VEVDAPSADGSTPLLLATANDHLAVARQLIEAGAD-VNRQ-NSRL---DSPYLLAGAEG 92
Cdd:cd22192  21 LLLAAKENDVQAIKKLLKCPsCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPmTSDLyqgETALHIAVVNQ 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  93 RLEILRLTLLHGADLkSTNRYGGTALIPAcerghvevVKTLLQAGvdpnhvnklgwtgllEAILLSDGGPRHQEIVRLLI 172
Cdd:cd22192 101 NLNLVRELIARGADV-VSPRATGTFFRPG--------PKNLIYYG---------------EHPLSFAACVGNEEIVRLLI 156

                       170
                ....*....|....*..
gi 15597694 173 DAGADVNLADADGVSPL 189
Cdd:cd22192 157 EHGADIRAQDSLGNTVL 173
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 51-210 2.31e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.40  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   51 PLLLATANDHLAVARQLIEAGADVNRQNSRLDSPYLLAGAE----GRLEILRLTllhgadLKSTNRYGGTALIPACERGH 126
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEpnklGMKEMIRSI------NKCSVFYTLVAIKDAFNNRN 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  127 VEVVKTLL------QAGVDPNHVNKLGWTGLLEAillsdggprhqEIVRLLIDAGADVNLADAD-GVSPLAHARQRGQGG 199
Cdd:PHA02878 114 VEIFKIILtnryknIQTIDLVYIDKKSKDDIIEA-----------EITKLLLSYGADINMKDRHkGNTALHYATENKDQR 182

                        170
                 ....*....|.
gi 15597694  200 IERLLLAAGAQ 210
Cdd:PHA02878 183 LTELLLSYGAN 193
PHA02791 PHA02791
ankyrin-like protein; Provisional
 28-159 5.94e-04

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 39.64  E-value: 5.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   28 TAQVASLLERKvevDAPSAD--GSTPLLLATANDHLAVARQLIEAGADVNRQNSRLdsPYLLAGAEGRLEILRLTLLHGA 105
Cdd:PHA02791  11 SKQLKSFLSSK---DAFKADvhGHSALYYAIADNNVRLVCTLLNAGALKNLLENEF--PLHQAATLEDTKIVKILLFSGM 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15597694  106 DLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGW-TGLLEAILLSD 159
Cdd:PHA02791  86 DDSQFDDKGNTALYYAVDSGNMQTVKLFVKKNWRLMFYGKTGWkTSFYHAVMLND 140
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 34-209 8.56e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 39.85  E-value: 8.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   34 LLERKVEVDAPSADGSTPLLLATANDhlAVARQLIEAGADVNRQNSRLDSPYLLAGAEGRLEILRLTLLHGADLKSTNRY 113
Cdd:PLN03192 513 LGDNGGEHDDPNMASNLLTVASTGNA--ALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDAN 590

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  114 GGTALIPACERGHVEVVKTLLQ--AGVDPNHVNKLgwtgLLEAILLSDggprhQEIVRLLIDAGADVNLADADGVSPLAH 191
Cdd:PLN03192 591 GNTALWNAISAKHHKIFRILYHfaSISDPHAAGDL----LCTAAKRND-----LTAMKELLKQGLNVDSEDHQGATALQV 661

                        170
                 ....*....|....*...
gi 15597694  192 ARQRGQGGIERLLLAAGA 209
Cdd:PLN03192 662 AMAEDHVDMVRLLIMNGA 679
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 47-75 1.30e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.30e-03
                           10        20
                   ....*....|....*....|....*....
gi 15597694     47 DGSTPLLLATANDHLAVARQLIEAGADVN 75
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02798 PHA02798
ankyrin-like protein; Provisional
 94-189 1.53e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 38.66  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694   94 LEILRLTLLHGADLKS-TNRYGgtalIPACE--------RGHVEVVKTLLQAGVDPNHVNKLGWTGLLeaILLSDGGPRH 164
Cdd:PHA02798  51 TDIVKLFINLGANVNGlDNEYS----TPLCTilsnikdyKHMLDIVKILIENGADINKKNSDGETPLY--CLLSNGYINN 124

                         90       100
                 ....*....|....*....|....*
gi 15597694  165 QEIVRLLIDAGADVNLADADGVSPL 189
Cdd:PHA02798 125 LEILLFMIENGADTTLLDKDGFTML 149
Ank_5 pfam13857
Ankyrin repeats (many copies);
105-149 1.60e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 1.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15597694   105 ADLKSTNRYGGTALIPACERGHVEVVKTLLQAGVDPNHVNKLGWT 149
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLT 51
Ank_4 pfam13637
Ankyrin repeats (many copies);
19-68 2.17e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.94  E-value: 2.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 15597694    19 LLEAARRGDTAQVASLLERKVEVDAPSADGSTPLLLATANDHLAVARQLI 68
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 47-78 2.67e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 2.67e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 15597694    47 DGSTPLLLATA-NDHLAVARQLIEAGADVNRQN 78
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 113-145 3.93e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.80  E-value: 3.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 15597694   113 YGGTAL-IPACERGHVEVVKTLLQAGVDPNHVNK 145
Cdd:pfam00023   1 DGNTPLhLAAGRRGNLEIVKLLLSKGADVNARDK 34
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 127-209 4.08e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 37.34  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  127 VEVVKTLLQAGVDPNHVNKLGWTGLLEAILLSDGGPRHQEIVRLLIDAGADVNLADADGVSPLAHA--RQRGQGGIERLL 204
Cdd:PHA03100  48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEYL 127


                 ....*
gi 15597694  205 LAAGA 209
Cdd:PHA03100 128 LDNGA 132
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 19-118 5.06e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 37.17  E-value: 5.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597694  19 LLEAARRGDTAqvasllerKVEVDAPSAD----GSTPLLLATANDHLAVARQLIEAGADVN-RQNSRL------------ 81
Cdd:cd21882  48 LLEAAPDSGNP--------KELVNAPCTDefyqGQTALHIAIENRNLNLVRLLVENGADVSaRATGRFfrkspgnlfyfg 119

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15597694  82 DSPYLLAGAEGRLEILRLTLLHGAD---LKSTNRYGGTAL 118
Cdd:cd21882 120 ELPLSLAACTNQEEIVRLLLENGAQpaaLEAQDSLGNTVL 159
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 168-209 9.81e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 36.41  E-value: 9.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 15597694  168 VRLLIDAGADVNLADADGVSPLAHARQRGQGGIERLLLAAGA 209
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGA 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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