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Conserved domains on  [gi|15597840|ref|NP_251334|]
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NADH-quinone oxidoreductase subunit I [Pseudomonas aeruginosa PAO1]

Protein Classification

NuoI/complex I 23 kDa subunit family protein( domain architecture ID 11481829)

NuoI/complex I 23 kDa subunit family protein such as bacterial NADH-quinone oxidoreductase subunit I (NuoI), which is part of the connecting domain of complex I of the respiratory chain that couples the transfer of electrons from NADH to quinone with the translocation of protons across the membrane

EC:  7.1.1.-
Gene Ontology:  GO:0016651|GO:0051539|GO:0016020
PubMed:  23417064|33957129|24059520

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
16-156 6.34e-77

NADH-quinone oxidoreductase subunit NuoI;


:

Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 227.07  E-value: 6.34e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840   16 LRSLVMIFGHAFRKRDTLQYPEEPVYLPPRYRGRIVLTRDPDGEERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFR 95
Cdd:PRK05888  14 LKGLGVTLKYFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEAAEREDGRRRTTRYD 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597840   96 INFSRCIFCGLCEEACPTTAIQLTPDFEMGEFKRQDLVYEKHDLLISG--------PGKNPDYNYYRVA 156
Cdd:PRK05888  94 INFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGdrvereiaPGKAADANYRGEA 162
 
Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
16-156 6.34e-77

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 227.07  E-value: 6.34e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840   16 LRSLVMIFGHAFRKRDTLQYPEEPVYLPPRYRGRIVLTRDPDGEERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFR 95
Cdd:PRK05888  14 LKGLGVTLKYFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEAAEREDGRRRTTRYD 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597840   96 INFSRCIFCGLCEEACPTTAIQLTPDFEMGEFKRQDLVYEKHDLLISG--------PGKNPDYNYYRVA 156
Cdd:PRK05888  94 INFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGdrvereiaPGKAADANYRGEA 162
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 18-139 1.12e-68

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 204.57  E-value: 1.12e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840    18 SLVMIFGHAFRKRDTLQYPEEPVYLPPRYRGRIVLTRDPDGEERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFRIN 97
Cdd:TIGR01971   1 GLGLTLKYFFSKPVTVQYPEEKLYLPPRFRGRIVLTRDPNGEEKCIGCTLCAAVCPADAIRVVPAEGEDGKRRLKFYEIN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 15597840    98 FSRCIFCGLCEEACPTTAIQLTPDFEMGEFKRQDLVYEKHDL 139
Cdd:TIGR01971  81 FGRCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 59-131 1.82e-20

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 80.17  E-value: 1.82e-20
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597840  59 EERCVACNLCAVACPVGCISLQKAETedgrwyPEFFRINFSRCIFCGLCEEACPTTAIQLTPdFEMGEFKRQD 131
Cdd:COG1143   1 EDKCIGCGLCVRVCPVDAITIEDGEP------GKVYVIDPDKCIGCGLCVEVCPTGAISMTP-FELAVEDREE 66
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 59-136 3.31e-14

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 65.88  E-value: 3.31e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597840  59 EERCVACNLCAVACPVGCISLQKAETedgrwYPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFEMGEFKRQDLVYEK 136
Cdd:cd10549   5 PEKCIGCGICVKACPTDAIELGPNGA-----IARGPEIDEDKCVFCGACVEVCPTGAIELTPEGKEYVPKEKEAEIDE 77
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 62-115 4.65e-11

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 55.61  E-value: 4.65e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15597840    62 CVACNLCAVACPVGCISLQKAETEDGRwypEFFRINFSRCIFCGLCEEACPTTA 115
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKGT---KTVVIDPERCVGCGACVAVCPTGA 51
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 60-117 4.39e-06

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 45.24  E-value: 4.39e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15597840   60 ERCVACNLCAVACPVGCISLqkaetEDGRwyPEFfrinFSRCIFCGLCEEACPTTAIQ 117
Cdd:NF038196 185 DKCIGCGICAKVCPVNNIEM-----EDGK--PVW----GHNCTHCLACIHRCPKEAIE 231
 
Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
16-156 6.34e-77

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 227.07  E-value: 6.34e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840   16 LRSLVMIFGHAFRKRDTLQYPEEPVYLPPRYRGRIVLTRDPDGEERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFR 95
Cdd:PRK05888  14 LKGLGVTLKYFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEAAEREDGRRRTTRYD 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597840   96 INFSRCIFCGLCEEACPTTAIQLTPDFEMGEFKRQDLVYEKHDLLISG--------PGKNPDYNYYRVA 156
Cdd:PRK05888  94 INFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGdrvereiaPGKAADANYRGEA 162
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 18-139 1.12e-68

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 204.57  E-value: 1.12e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840    18 SLVMIFGHAFRKRDTLQYPEEPVYLPPRYRGRIVLTRDPDGEERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFRIN 97
Cdd:TIGR01971   1 GLGLTLKYFFSKPVTVQYPEEKLYLPPRFRGRIVLTRDPNGEEKCIGCTLCAAVCPADAIRVVPAEGEDGKRRLKFYEIN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 15597840    98 FSRCIFCGLCEEACPTTAIQLTPDFEMGEFKRQDLVYEKHDL 139
Cdd:TIGR01971  81 FGRCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 32-135 2.30e-24

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 93.56  E-value: 2.30e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840   32 TLQYPEEPVYLPPRYRGRivltrdPDGE-ERCVACNLCAVACPVGCISLQKAETEDGR-WypeffRINFSRCIFCGLCEE 109
Cdd:PRK12387  15 TSSYPLEPIAVDKNFRGK------PEYNpQQCIGCAACVNACPSNALTVETDLATGELaW-----EFNLGRCIFCGRCEE 83

                         90       100
                 ....*....|....*....|....*.
gi 15597840  110 ACPTTAIQLTPDFEMGEFKRQDLVYE 135
Cdd:PRK12387  84 VCPTAAIKLSQEFELAVWKKEDLLQQ 109
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 59-131 1.82e-20

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 80.17  E-value: 1.82e-20
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597840  59 EERCVACNLCAVACPVGCISLQKAETedgrwyPEFFRINFSRCIFCGLCEEACPTTAIQLTPdFEMGEFKRQD 131
Cdd:COG1143   1 EDKCIGCGLCVRVCPVDAITIEDGEP------GKVYVIDPDKCIGCGLCVEVCPTGAISMTP-FELAVEDREE 66
PRK08222 PRK08222
hydrogenase 4 subunit H; Validated
 32-132 7.26e-20

hydrogenase 4 subunit H; Validated


Pssm-ID: 181301 [Multi-domain]  Cd Length: 181  Bit Score: 82.11  E-value: 7.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840   32 TLQYPEEPVYLPPRYRGRIVLtrDPdgeERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFrinfSRCIFCGLCEEAC 111
Cdd:PRK08222  15 TVKYPFAPLEVSPGFRGKPDL--MP---SQCIACGACTCACPANALTIQTDDQQNSRTWQLYL----GRCIYCGRCEEVC 85

                         90       100
                 ....*....|....*....|.
gi 15597840  112 PTTAIQLTPDFEMGEFKRQDL 132
Cdd:PRK08222  86 PTRAIQLTNNFELTVTNKADL 106
ndhI TIGR00403
NADH-plastoquinone oxidoreductase subunit I protein; [Energy metabolism, Electron transport]
 17-136 1.42e-17

NADH-plastoquinone oxidoreductase subunit I protein; [Energy metabolism, Electron transport]


Pssm-ID: 129498 [Multi-domain]  Cd Length: 183  Bit Score: 76.11  E-value: 1.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840    17 RSLVMIFGHAFRKRDTLQYPEEPVYLPPRYRGRIVLTRDpdgeeRCVACNLCAVACPVGCISLQ-KAETEDGRWYPEFFR 95
Cdd:TIGR00403  24 QGFAVTLDHMNRLPITIQYPYEKLIPSERFRGRIHFEFD-----KCIACEVCVRVCPINLPVVDwEFNKAIKKKQLKNYS 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 15597840    96 INFSRCIFCGLCEEACPTTAIQLTPDFEMGEFKRQDLVYEK 136
Cdd:TIGR00403  99 IDFGVCIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYDQ 139
ndhI CHL00014
NADH dehydrogenase subunit I
 1-134 1.99e-17

NADH dehydrogenase subunit I


Pssm-ID: 214334 [Multi-domain]  Cd Length: 167  Bit Score: 75.18  E-value: 1.99e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840    1 MIKEIINVVHGTFTQLR----SLVMIFGHAFRKRDTLQYPEEPVYLPPRYRGRIVLTRDpdgeeRCVACNLCAVACPvgc 76
Cdd:CHL00014   1 MVTGFMNYGQQTIRAARyigqGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFD-----KCIACEVCVRVCP--- 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597840   77 ISLQ----KAETEDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFEMGEFKRQDLVY 134
Cdd:CHL00014  73 IDLPvvdwKLETDIRKKRLLNYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNY 134
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 16-131 6.67e-15

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 67.55  E-value: 6.67e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840   16 LRSLVMIFGHAFRKRDTLQYPE-EPVYLPPRYRGRIVLTRDpdgeeRCVACNLCAVACPVGCISlqkaetedgrWYPEFF 94
Cdd:PRK08348   2 LPLLPTVLRNLFKKPATNLFPAtEPVPVPEDFRGKILYDVD-----KCVGCRMCVTVCPAGVFV----------YLPEIR 66

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 15597840   95 RINF--SRCIFCGLCEEACPTTAIQLTPDFEMGEFKRQD 131
Cdd:PRK08348  67 KVALwtGRCVFCGQCVDVCPTGALQMSDDFLLASYDRFD 105
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 59-136 3.31e-14

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 65.88  E-value: 3.31e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597840  59 EERCVACNLCAVACPVGCISLQKAETedgrwYPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFEMGEFKRQDLVYEK 136
Cdd:cd10549   5 PEKCIGCGICVKACPTDAIELGPNGA-----IARGPEIDEDKCVFCGACVEVCPTGAIELTPEGKEYVPKEKEAEIDE 77
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 59-124 8.83e-14

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 64.73  E-value: 8.83e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597840  59 EERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFrINFSRCIFCGLCEEACPTTAIQLTPDFEM 124
Cdd:cd10549  39 EDKCVFCGACVEVCPTGAIELTPEGKEYVPKEKEAE-IDEEKCIGCGLCVKVCPVDAITLEDELEI 103
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
59-124 1.12e-13

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 62.83  E-value: 1.12e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597840  59 EERCVACNLCAVACPVGCISLQKaetedgrwypEFFRINFSRCIFCGLCEEACPTTAIQLTPDFEM 124
Cdd:COG2768  10 EEKCIGCGACVKVCPVGAISIED----------GKAVIDPEKCIGCGACIEVCPVGAIKIEWEEDE 65
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 59-123 1.11e-12

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 60.45  E-value: 1.11e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597840  59 EERCVACNLCAVACPVGCISLqkaetEDGRWYpeffRINFSRCIFCGLCEEACPTTAIQLTPDFE 123
Cdd:COG1144  29 EDKCIGCGLCWIVCPDGAIRV-----DDGKYY----GIDYDYCKGCGICAEVCPVKAIEMVPEEK 84
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 30-119 1.51e-12

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 61.26  E-value: 1.51e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840  30 RDTLQYPEEPVYLPPRYRGRIVltrdpdGEERCVACNLCAVACPVGCISLQKaetedgrwyPEFFRINFSRCIFCGLCEE 109
Cdd:cd10549  54 TGAIELTPEGKEYVPKEKEAEI------DEEKCIGCGLCVKVCPVDAITLED---------ELEIVIDKEKCIGCGICAE 118

                        90
                ....*....|
gi 15597840 110 ACPTTAIQLT 119
Cdd:cd10549 119 VCPVNAIKLV 128
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 59-116 1.82e-12

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 59.68  E-value: 1.82e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15597840  59 EERCVACNLCAVACPVGCISLqkaetEDGRwypefFRINFSRCIFCGLCEEACPTTAI 116
Cdd:COG2221  14 EEKCIGCGLCVAVCPTGAISL-----DDGK-----LVIDEEKCIGCGACIRVCPTGAI 61
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 59-121 1.02e-11

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 57.41  E-value: 1.02e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597840  59 EERCVACNLCAVACPVGCISLQkaetEDGrwyPEFFRINFSRCIFCGLCEEACPTTAIQLTPD 121
Cdd:COG1146   7 TDKCIGCGACVEVCPVDVLELD----EEG---KKALVINPEECIGCGACELVCPVGAITVEDD 62
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 62-115 4.65e-11

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 55.61  E-value: 4.65e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15597840    62 CVACNLCAVACPVGCISLQKAETEDGRwypEFFRINFSRCIFCGLCEEACPTTA 115
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKGT---KTVVIDPERCVGCGACVAVCPTGA 51
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 59-120 2.35e-10

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 53.96  E-value: 2.35e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597840  59 EERCVACNLCAVACPVGCISLqkaetEDGRWYpeffRINFSRCIFCGLCEEACPTTAIQLTP 120
Cdd:COG1149  10 EEKCIGCGLCVEVCPEGAIKL-----DDGGAP----VVDPDLCTGCGACVGVCPTGAITLEE 62
PRK13984 PRK13984
putative oxidoreductase; Provisional
 27-122 2.60e-10

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 58.24  E-value: 2.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840   27 FRKRDTLQYPEEPVYLPPRYRGRIVltrdpDGEERCVACNLCAVACPVGCISLQKAE---TEDGRwYPEFFRINFSRCIF 103
Cdd:PRK13984  17 FRKPVTIKVPNVKREAAERYRGFHI-----NDWEKCIGCGTCSKICPTDAITMVEVPdlpQEYGK-KPQRPVIDYGRCSF 90

                         90
                 ....*....|....*....
gi 15597840  104 CGLCEEACPTTAIQLTPDF 122
Cdd:PRK13984  91 CALCVDICTTGSLKMTREY 109
NapF COG1145
Ferredoxin [Energy production and conversion];
59-120 2.72e-10

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 57.43  E-value: 2.72e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597840  59 EERCVACNLCAVACPVGCISLqkaetEDGRWYPEFFRinfSRCIFCGLCEEACPTTAIQLTP 120
Cdd:COG1145 181 AEKCIGCGLCVKVCPTGAIRL-----KDGKPQIVVDP---DKCIGCGACVKVCPVGAISLEP 234
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 59-118 4.31e-10

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 53.51  E-value: 4.31e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840  59 EERCVACNLCAVACPVGCISLQKaetedgrwypEFFRINFSRCIFCGLCEEACPTTAIQL 118
Cdd:COG4231  21 EDKCTGCGACVKVCPADAIEEGD----------GKAVIDPDLCIGCGSCVQVCPVDAIKL 70
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
47-125 8.31e-10

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 56.22  E-value: 8.31e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597840  47 RGRIVLTRDPDgeeRCVACNLCAVACPVGCISLQKaetedgrwypeffRINFSRCIFCGLCEEACPTTAIQLTPDFEMG 125
Cdd:COG0348 200 LSTLRVRYDRG---DCIDCGLCVKVCPMGIDIRKG-------------EINQSECINCGRCIDACPKDAIRFSSRGEKT 262
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 60-119 1.91e-08

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 50.71  E-value: 1.91e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597840  60 ERCVACNLCAVACPVGCISLQkaetEDGrwYPEffrINFSR--CIFCGLCEEACPTTAIQLT 119
Cdd:cd10564  13 DLCTRCGDCVEACPEGIIVRG----DGG--FPE---LDFSRgeCTFCGACAEACPEGALDPA 65
PRK13795 PRK13795
hypothetical protein; Provisional
 61-112 3.68e-08

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 51.92  E-value: 3.68e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 15597840   61 RCVACNLCAVACPVGCISLqkaeTEDGRWypefFRINFSRCIFCGLCEEACP 112
Cdd:PRK13795 582 ECVGCGVCVGACPTGAIRI----EEGKRK----ISVDEEKCIHCGKCTEVCP 625
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
59-118 3.68e-08

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 52.17  E-value: 3.68e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840  59 EERCVACNLCAVACPVGCISlqkaetEDGRWYPEffrINFSRCIFCGLCEEACPTTAIQL 118
Cdd:COG1148 495 PEKCTGCGRCVEVCPYGAIS------IDEKGVAE---VNPALCKGCGTCAAACPSGAISL 545
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 59-118 3.72e-08

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 49.95  E-value: 3.72e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597840  59 EERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFRINFsRCIFCG------LCEEACPTTAIQL 118
Cdd:cd10554  84 EERCIGCKLCVLACPFGAIEMAPTTVPGVDWERGPRAVAV-KCDLCAgreggpACVEACPTKALTL 148
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
59-123 5.14e-08

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 51.57  E-value: 5.14e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597840  59 EERCVACNLCAVACPVGCISLQKAETEdgrwypeffrINFSRCIFCGLCEEACPTTAIQLTPDFE 123
Cdd:COG4624  90 KEKCKNCYPCVRACPVKAIKVDDGKAE----------IDEEKCISCGQCVAVCPFGAITEKSDIE 144
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
52-119 9.68e-08

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 48.89  E-value: 9.68e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597840  52 LTRDPDG----EERCVACNLCAVACPVGCIslqkaetedgRWYPEFFRINFSRCIFCG------LCEEACPTTAIQLT 119
Cdd:COG1142  69 ITRDDGAvvvdEEKCIGCGLCVLACPFGAI----------TMVGEKSRAVAVKCDLCGgreggpACVEACPTGALRLV 136
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 61-123 1.31e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 48.79  E-value: 1.31e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597840  61 RCVACNLCAVACPVGCIslQKAETEDGR---WYPeffRINFSR--CIFCG-LCEEACPTTAIQLTPDFE 123
Cdd:cd16373  15 LCIRCGLCVEACPTGVI--QPAGLEDGLeggRTP---YLDPREgpCDLCCdACVEVCPTGALRPLDLEE 78
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 49-121 1.59e-07

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 48.15  E-value: 1.59e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597840  49 RIVLTRDPDGEERCVACNLC-----AVACPVGCISlqkaETEDGrwypeFFRINFSRCIFCGLCEEACPTTAIQLTPD 121
Cdd:cd04410  34 KVIEGGGLERAFLPVSCMHCedppcVKACPTGAIY----KDEDG-----IVLIDEDKCIGCGSCVEACPYGAIVFDPE 102
Fer4_9 pfam13187
4Fe-4S dicluster domain;
61-116 2.81e-07

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 45.24  E-value: 2.81e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15597840    61 RCVACNLCAVACPVGCISLQKAETEDgrwypeFFRINFSRCIFCGLCEEACPTTAI 116
Cdd:pfam13187   1 KCTGCGACVAACPAGAIVPDLVGQTI------RGDIAGLACIGCGACVDACPRGAI 50
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 59-120 8.46e-07

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 47.68  E-value: 8.46e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597840  59 EERCVACNLCAVACPVGCISLqkaeTEDGrwypeFFRINFSRCIFCGLCEEACPTTAIQLTP 120
Cdd:COG2878 136 EYGCIGCGDCIKACPFDAIVG----AAKG-----MHTVDEDKCTGCGLCVEACPVDCIEMVP 188
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
62-119 1.33e-06

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 47.24  E-value: 1.33e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15597840   62 CVACNLCAVACPVGCISLqkaetEDGRWYpeffrINFSRCIFCGLCEEACPTTAIQLT 119
Cdd:PRK07118 215 CIGCGKCVKACPAGAITM-----ENNLAV-----IDQEKCTSCGKCVEKCPTKAIRIL 262
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 59-120 1.88e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 45.32  E-value: 1.88e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597840  59 EERCVA------CNLCAVACPVGCISLQKaetEDGRWYPEffrINFSRCIFCGLCEEACPTT---AIQLTP 120
Cdd:cd16373  90 KDRCLAwqggtdCGVCVEACPTEAIAIVL---EDDVLRPV---VDEDKCVGCGLCEYVCPVEppkAIVVEP 154
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 59-112 2.51e-06

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 43.01  E-value: 2.51e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15597840    59 EERCVACNLCAVACPVGCISLQKAEtedGRWYPEFFRINFSRCIFCGLCEEACP 112
Cdd:pfam13237   6 PDKCIGCGRCTAACPAGLTRVGAIV---ERLEGEAVRIGVWKCIGCGACVEACP 56
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 52-152 3.74e-06

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 45.28  E-value: 3.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840  52 LTRDPDG-----EERCVACNLCAVACPVGCISLQkaetedgrWYPEFFRInfSRCIFC------GL---CEEACPTTAIQ 117
Cdd:cd10561  86 LRKTPEGpvtydEDKCIGCRYCMVACPFNIPKYE--------WDSANPKI--RKCTMCydrlkeGKqpaCVEACPTGALL 155

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15597840 118 ltpdfemgeF-KRQDLVYEKHDLLISGPGKNPDYNY 152
Cdd:cd10561 156 ---------FgKREELLAEAKRRIAANPGRYVDHVY 182
vorD PRK09623
3-methyl-2-oxobutanoate dehydrogenase subunit delta;
34-118 3.94e-06

3-methyl-2-oxobutanoate dehydrogenase subunit delta;


Pssm-ID: 170016 [Multi-domain]  Cd Length: 105  Bit Score: 43.78  E-value: 3.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840   34 QYPEEPVYLppryrGRIVLTRDPD--------GEERCVACNLCAVACPVGCISLQkaetEDGrwypeFFRINFSRCIFCG 105
Cdd:PRK09623  22 EYPEAPISL-----GTTLSNFTGDwrtfmpvvDESKCVKCYICWKFCPEPAIYIK----EDG-----YVAIDYDYCKGCG 87

                         90
                 ....*....|...
gi 15597840  106 LCEEACPTTAIQL 118
Cdd:PRK09623  88 ICANECPTKAITM 100
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 60-117 4.39e-06

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 45.24  E-value: 4.39e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15597840   60 ERCVACNLCAVACPVGCISLqkaetEDGRwyPEFfrinFSRCIFCGLCEEACPTTAIQ 117
Cdd:NF038196 185 DKCIGCGICAKVCPVNNIEM-----EDGK--PVW----GHNCTHCLACIHRCPKEAIE 231
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 62-120 4.87e-06

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 45.64  E-value: 4.87e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 15597840   62 CVACNLCAVACPVGCISLQKAETEDgrwypeffRINFSRCIFCGLCEEACPTTAIQLTP 120
Cdd:PRK12771 512 CFECDNCYGACPQDAIIKLGPGRRY--------HFDYDKCTGCHICADVCPCGAIEMGP 562
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 46-121 5.27e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 43.72  E-value: 5.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840  46 YRGRI-VLTRDPDGEERCVACN-----LCAVACPVGCISLQKaetEDGRWypeffRINFSRCIFCGLCEEACPTTAIQLT 119
Cdd:cd10550  29 SLSRIrVVRFEPEGLDVPVVCRqcedaPCVEACPVGAISRDE---ETGAV-----VVDEDKCIGCGMCVEACPFGAIRVD 100


                ..
gi 15597840 120 PD 121
Cdd:cd10550 101 PE 102
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 59-118 5.37e-06

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 43.48  E-value: 5.37e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840   59 EERCVACNLCAVACPVGCISLqkaeteDGRWYPEFfriNFSRCIFCGLCEEACPTTAIQL 118
Cdd:PRK09624  50 RDKCVRCYLCYIYCPEPAIYL------DEEGYPVF---DYDYCKGCGICANECPTKAIEM 100
PRK09898 PRK09898
ferredoxin-like protein;
59-120 5.67e-06

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 44.83  E-value: 5.67e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597840   59 EERCVACNLCAVACPVGcisLQKAETEDGRwypeffrinFSRCIFCGLCEEACPTTAIQLTP 120
Cdd:PRK09898 153 HKRCIGCSACTTACPWM---MATVNTESKK---------SSKCVLCGECANACPTGALKIIE 202
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 51-118 5.76e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 43.48  E-value: 5.76e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597840  51 VLTRDPDG-----EERCVACNLCAVACPVGciSLQKAETedgrwypeffRINFSRCIFCGLCEEACPTTAIQL 118
Cdd:cd16372  63 AITRDANGvvminKKLCVGCLMCVGFCPEG--AMFKHED----------YPEPFKCIACGICVKACPTGALEL 123
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 61-118 7.75e-06

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 44.99  E-value: 7.75e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597840   61 RCVACNLCAVACPVGCI--SLQKAETEDGRWY-PEFFRINFSRCIFCGLCEEACPTTAIQL 118
Cdd:PRK14028 248 KCIMCRKCWLYCPDDAIieAWREAEGPRGRKFrMKMIDFDYQYCKGCGVCAEVCPTGAIQM 308
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
37-120 9.10e-06

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 43.49  E-value: 9.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840  37 EEPVYLPPRYRGRIVLTRDPDGEERCVACNL--CAVACPVGCISLqkaetEDGRWYpeffrINFSRCIFCGLCEEACPTT 114
Cdd:COG1142  27 EGEEGEPFLPRIRVVRKAGVSAPVQCRHCEDapCAEVCPVGAITR-----DDGAVV-----VDEEKCIGCGLCVLACPFG 96


                ....*.
gi 15597840 115 AIQLTP 120
Cdd:COG1142  97 AITMVG 102
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
 61-116 9.57e-06

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 42.63  E-value: 9.57e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15597840    61 RCVACNLCAVACPVGCISLQKAEtedgrwYPEFfRINFSRCIFCGLCEEACPTTAI 116
Cdd:TIGR00402  35 VCTRCGECASACENNILQLGQQG------QPTV-EFDNAECDFCGKCAEACPTNAF 83
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 52-118 9.89e-06

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 43.15  E-value: 9.89e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840  52 LTRDPDG-----EERCVACNLCAVACPVGCISLQKAETEDgrwypeffrinfSRCIFCG---------LCEEACPTTAIQ 117
Cdd:cd04410  67 IYKDEDGivlidEDKCIGCGSCVEACPYGAIVFDPEPGKA------------VKCDLCGdrldeglepACVKACPTGALT 134


                .
gi 15597840 118 L 118
Cdd:cd04410 135 F 135
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 68-120 1.10e-05

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 43.40  E-value: 1.10e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 15597840  68 CAVACPVGCISLqkaetEDGRwypefFRINFSRCIFCGLCEEACPTTAIQLTP 120
Cdd:cd10554  64 CANVCPVGAISQ-----EDGV-----VQVDEERCIGCKLCVLACPFGAIEMAP 106
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 59-117 2.03e-05

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 43.44  E-value: 2.03e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597840  59 EERCVACNLCAVACPVGCISLQKAETEDGR--WYPEFFRINFSRCIfcGLCEEACPTTAIQ 117
Cdd:COG2878 166 EDKCTGCGLCVEACPVDCIEMVPVSPTVVVssWDKGKAVRKVVGCI--GLCCKKCCPAAAI 224
oorD PRK09626
2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed
 59-128 2.03e-05

2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed


Pssm-ID: 236597 [Multi-domain]  Cd Length: 103  Bit Score: 41.63  E-value: 2.03e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597840   59 EERCVACNLCAVACPVGCISLQKAETED-GRW----YPEffrinfsRCIFCGLCEEACPTTAIQLTpdfEMGEFK 128
Cdd:PRK09626  15 ESRCKACDICVSVCPAGVLAMRIDPHAVlGKMikvvHPE-------SCIGCRECELHCPDFAIYVA---DRKEFK 79
PRK08318 PRK08318
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;
59-89 2.24e-05

NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;


Pssm-ID: 236237 [Multi-domain]  Cd Length: 420  Bit Score: 43.78  E-value: 2.24e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 15597840   59 EERCVACNLCAVACPV-GCISLQKAETEDG--RW 89
Cdd:PRK08318 376 EEECVGCNLCAHVCPVeGCITMGEVKFGKPyaNW 409
PRK09898 PRK09898
ferredoxin-like protein;
68-112 2.39e-05

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 42.90  E-value: 2.39e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 15597840   68 CAVACPVGCISLQKaetEDGRWYpeffrINFSRCIFCGLCEEACP 112
Cdd:PRK09898 131 CMNVCPIGAITWQQ---KEGCIT-----VDHKRCIGCSACTTACP 167
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 54-116 2.48e-05

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 42.90  E-value: 2.48e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15597840  54 RDPDG-----EERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFRINFSRCIFC------GL---CEEACPTTAI 116
Cdd:cd10551  72 KREDGivlvdYDKCIGCRYCMAACPYGARYFNPEEPHEFGEVPVRPKGVVEKCTFCyhrldeGLlpaCVEACPTGAR 148
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 63-120 3.50e-05

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 41.85  E-value: 3.50e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15597840  63 VACNLCAVACPVGCISLQkaETEDGRWYPEffrINFSRCIFCGLCEEACPTTAIQLTP 120
Cdd:cd10564  86 VECRSCQDACPTQAIRFR--PRLGGIALPE---LDADACTGCGACVSVCPVGAITLTP 138
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 62-124 3.94e-05

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 42.37  E-value: 3.94e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597840  62 CVACNLCAVACPVGCISLQKaetEDGRWYpeffrinfsRCIFC------GL---CEEACPTTAIQLTPDFEM 124
Cdd:cd10560 110 CNGCGYCVAACPFGVIDRNE---ETGRAH---------KCTLCydrlkdGLepaCAKACPTGSIQFGPLEEL 169
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 60-121 4.85e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 41.39  E-value: 4.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840  60 ERCVACNLCAVAC------PVGcISLQKAETEDGRWYPEFFRINFS---------------------------------R 100
Cdd:cd16371   7 ERCIGCKACEIACkdkndlPPG-VNWRRVYEYEGGEFPEVFAYFLSmscnhcenpacvkvcptgaitkredgivvvdqdK 85

                        90       100
                ....*....|....*....|.
gi 15597840 101 CIFCGLCEEACPTTAIQLTPD 121
Cdd:cd16371  86 CIGCGYCVWACPYGAPQYNPE 106
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 52-119 5.13e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 41.02  E-value: 5.13e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15597840  52 LTRDPDG------EERCVACNLCAVACPVGCISLQkaeTEDGRwypeffrinFSRCIFCG---LCEEACPTTAIQLT 119
Cdd:cd10550  66 ISRDEETgavvvdEDKCIGCGMCVEACPFGAIRVD---PETGK---------AIKCDLCGgdpACVKVCPTGALEFV 130
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 68-121 6.23e-05

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 41.52  E-value: 6.23e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 15597840  68 CAVACPVGCISlqkaETEDGrwypeFFRINFSRCIFCGLCEEACPTTAIQLTPD 121
Cdd:cd10562  78 CVKVCPTGALY----KTENG-----AVVVDEDKCIGCGYCVAACPFDVPRYDET 122
PRK06273 PRK06273
ferredoxin; Provisional
 59-112 8.06e-05

ferredoxin; Provisional


Pssm-ID: 235764 [Multi-domain]  Cd Length: 165  Bit Score: 41.23  E-value: 8.06e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 15597840   59 EERCVACNLCAVACPVGCISLQKAE----TEDgrWYPEFF-RINFSRCIFCGLCEEACP 112
Cdd:PRK06273  48 EELCIGCGGCANVCPTKAIEMIPVEpvkiTEG--YVKTKIpKIDYEKCVYCLYCHDFCP 104
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 52-117 8.65e-05

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 41.09  E-value: 8.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840  52 LTRDPDG-----EERCVACNLCAVACPVGCISLQKaetEDGRWYpeffrinfsRCIFCG---------LCEEACPTTAIQ 117
Cdd:COG0437  77 TYKREDGivlvdYDKCIGCRYCVAACPYGAPRFNP---ETGVVE---------KCTFCAdrldegllpACVEACPTGALV 144
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 82-121 1.02e-04

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 39.26  E-value: 1.02e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15597840  82 AETEDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPD 121
Cdd:COG1144  13 AAYKTGGWRVERPVVDEDKCIGCGLCWIVCPDGAIRVDDG 52
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 59-130 1.24e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 41.66  E-value: 1.24e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597840   59 EERCVACNLCAVACPVGCISLQKAETEDGRwypefFRINFSRCIFCG------LCEEACPTTAIQLTPDFEMGEFKRQ 130
Cdd:PRK12769  84 QQKCIGCKSCVVACPFGTMQIVLTPVAAGK-----VKATAHKCDLCAgrengpACVENCPADALQLVTEQALSGMAKS 156
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 96-117 1.63e-04

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 37.23  E-value: 1.63e-04
                          10        20
                  ....*....|....*....|..
gi 15597840    96 INFSRCIFCGLCEEACPTTAIQ 117
Cdd:pfam00037   3 IDEEKCIGCGACVEVCPVGAIT 24
PRK08318 PRK08318
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;
59-120 1.78e-04

NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;


Pssm-ID: 236237 [Multi-domain]  Cd Length: 420  Bit Score: 41.08  E-value: 1.78e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597840   59 EERCVACNLCAVACPVG---CISLqkaeTEDGRWYPEffrINFSRCIFCGLCEEACPT-TAIQLTP 120
Cdd:PRK08318 341 QDKCIGCGRCYIACEDTshqAIEW----DEDGTRTPE---VIEEECVGCNLCAHVCPVeGCITMGE 399
porD PRK09625
pyruvate flavodoxin oxidoreductase subunit delta; Reviewed
 60-113 3.59e-04

pyruvate flavodoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 236596 [Multi-domain]  Cd Length: 133  Bit Score: 38.96  E-value: 3.59e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15597840   60 ERCVACNLCAVACPVGCIsLQKAETEDGrwypeffrINFSRCIFCGLCEEACPT 113
Cdd:PRK09625  59 EICINCFNCWVYCPDAAI-LSRDKKLKG--------VDYSHCKGCGVCVEVCPT 103
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 96-126 4.33e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 38.53  E-value: 4.33e-04
                        10        20        30
                ....*....|....*....|....*....|.
gi 15597840  96 INFSRCIFCGLCEEACPTTAIQLTPDFEMGE 126
Cdd:cd10549   3 YDPEKCIGCGICVKACPTDAIELGPNGAIAR 33
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 60-121 4.68e-04

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 39.16  E-value: 4.68e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597840  60 ERCVACNLCAVAC------PVGcISLQKAETEDGRWYPEFFRINFSR-CIFCG--LCEEACPTTAIQLTPD 121
Cdd:COG0437  13 TKCIGCRACVVACkeennlPVG-VTWRRVRRYEEGEFPNVEWLFVPVlCNHCDdpPCVKVCPTGATYKRED 82
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 52-129 4.80e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 38.41  E-value: 4.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840  52 LTRDPDG-----EERCVACNLCAVACPVGCISLQKAETedgrwypeffriNFSRCIFCG---------LCEEACPTTAIQ 117
Cdd:cd16374  60 IYRDEDGavlvdPDKCIGCGMCAMACPFGVPRFDPSLK------------VAVKCDLCIdrrregklpACVEACPTGALK 127

                        90
                ....*....|..
gi 15597840 118 LTPDFEMGEFKR 129
Cdd:cd16374 128 FGDIEELLKEKR 139
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 59-130 4.94e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 40.01  E-value: 4.94e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597840   59 EERCVACNLCAVACPVGCISLQKAETEdgrwypeffrinfsRCIFCG-------LCEEACPTTAIQLTPDFEMGEFKRQ 130
Cdd:PRK12809  84 EQKCIGCKRCAIACPFGVVEMVDTIAQ--------------KCDLCNqrssgtqACIEVCPTQALRLMDDKGLQQIKVA 148
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 87-118 4.98e-04

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 36.95  E-value: 4.98e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 15597840  87 GRWYPeffRINFSRCIFCGLCEEACPTTAIQL 118
Cdd:COG2221   6 GTWPP---KIDEEKCIGCGLCVAVCPTGAISL 34
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 52-118 5.82e-04

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 38.39  E-value: 5.82e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597840  52 LTRDP-DG-----EERCVACNLCAVACPVGCISlqkaetedgrwyPEFFRINFSRCIFCG-----LCEEACPTTAIQL 118
Cdd:cd10563  74 MHKDPeTGivihdEEKCVGCWMCVMVCPYGAIR------------PDKERKVALKCDLCPdretpACVEACPTGALVL 139
NapF COG1145
Ferredoxin [Energy production and conversion];
51-121 5.82e-04

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 39.32  E-value: 5.82e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597840  51 VLTRDPDGEERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPD 121
Cdd:COG1145 134 VIAAALAEAGLAILGAAAPVDALAISGGKKIEEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLKDG 204
Fer4_18 pfam13746
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 54-113 6.05e-04

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404610 [Multi-domain]  Cd Length: 114  Bit Score: 37.76  E-value: 6.05e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840    54 RDPDGEERCVACNLCAVACPVGcISLQKAetedgrwypefFRInfsRCIFCGLCEEACPT 113
Cdd:pfam13746  53 RQQKGVGDCIDCESCVQVCPTG-IDIRKG-----------LQL---ECINCGLCIDACNT 97
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 62-121 6.96e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 37.70  E-value: 6.96e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840  62 CVACNLCAVACPVGCISLQKaetedgrwyPEFFRINFSRCIFCGLCEEACPTTAIQLTPD 121
Cdd:cd16372  49 CNQCGECIDVCPTGAITRDA---------NGVVMINKKLCVGCLMCVGFCPEGAMFKHED 99
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 95-121 9.86e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 36.24  E-value: 9.86e-04
                        10        20
                ....*....|....*....|....*..
gi 15597840  95 RINFSRCIFCGLCEEACPTTAIQLTPD 121
Cdd:COG1149   7 VIDEEKCIGCGLCVEVCPEGAIKLDDG 33
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 60-121 1.05e-03

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 37.90  E-value: 1.05e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597840  60 ERCVACNLCAVAC------PVGcISLQKAETEDGRWYPEFFRINFSR-CIFCG--LCEEACPTTAIQLTPD 121
Cdd:cd10551   6 RKCIGCGACVVACkaennvPPG-VFRNRVLEYEVGEYPNVKRTFLPVlCNHCEnpPCVKVCPTGATYKRED 75
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 52-117 1.08e-03

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 37.76  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840  52 LTRDPDG-----EERCVACNLCAVACPVGCISLQKaetEDGRWYpeffrinfsRCIFC------GL---CEEACPTTAIQ 117
Cdd:cd16366  87 IIRTETGtvvvdPETCIGCGYCVNACPFDIPRFDE---ETGRVA---------KCTLCydrisnGLqpaCVKTCPTGALT 154
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 68-121 1.19e-03

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 38.00  E-value: 1.19e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 15597840  68 CAVACPVGCISlqkaETEDGrwypeFFRINFSRCIFCGLCEEACPTTAIQLTPD 121
Cdd:COG0437  68 CVKVCPTGATY----KREDG-----IVLVDYDKCIGCRYCVAACPYGAPRFNPE 112
ACS_1 cd01916
Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and ...
 44-113 1.23e-03

Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH) consisting of two ACS and two CODH subunits. CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP). ACS has three structural domains, an N-terminal rossman fold domain with a helical region at its N-terminus which interacts with CODH, and two alpha + beta fold domains. A Ni-Fe-S center referred to as the A-cluster is located in the C-terminal domain. A large cavity exists between the three domains which may bind CoA.


Pssm-ID: 238897 [Multi-domain]  Cd Length: 731  Bit Score: 38.54  E-value: 1.23e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15597840  44 PRYRGRIVLtrdPDGEE------RCVACNLCAVACPVGC-ISLQKAETEDGRWYPefFRINFSRCIFCGLCEEACPT 113
Cdd:cd01916 346 PKRKGEKKL---PTDEEfqelaaKCTDCGWCTRACPNSLrIKEAMEAAKEGDFSG--LADLFDQCVGCGRCEQECPK 417
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
62-121 1.27e-03

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 38.38  E-value: 1.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597840   62 CVACNLCAVACPVGCISLqkaetEDGrwypeFFRINFSRCIFCGLCEEACPTTAIQLTPD 121
Cdd:PRK07118 141 CLGLGSCVAACPFDAIHI-----ENG-----LPVVDEDKCTGCGACVKACPRNVIELIPK 190
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 59-121 1.32e-03

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 38.33  E-value: 1.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597840   59 EERCVACNLCAVACPVGCISLQKAETEDGRWYPeffrinfsrCIFCGLCEEACPTTAIQLTPD 121
Cdd:PRK00783 168 SEDCDECEKCVEACPRGVLELKEGKLVVTDLLN---------CSLCKLCERACPGKAIRVSDD 221
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 51-87 1.57e-03

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 35.46  E-value: 1.57e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15597840  51 VLTRDPDG-------EERCVACNLCAVACPVGCISLQKAETEDG 87
Cdd:COG1146  24 VLELDEEGkkalvinPEECIGCGACELVCPVGAITVEDDEPEEQ 67
Fer4_21 pfam14697
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 59-113 1.74e-03

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 434137 [Multi-domain]  Cd Length: 59  Bit Score: 35.33  E-value: 1.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15597840    59 EERCVACNLCAVACPVGCIslqKAETEDGRWYpefFRINFSRCIFCGLCEEACPT 113
Cdd:pfam14697   5 EDTCIGCGKCYIACPDTSH---QAIVGDGKRH---HTVIEDECTGCNLCVSVCPV 53
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 59-78 1.74e-03

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 34.53  E-value: 1.74e-03
                          10        20
                  ....*....|....*....|
gi 15597840    59 EERCVACNLCAVACPVGCIS 78
Cdd:pfam00037   5 EEKCIGCGACVEVCPVGAIT 24
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 42-118 1.92e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 36.87  E-value: 1.92e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15597840  42 LPPRYRGRIVLTRDpdgeeRCVACNLCAVACPVGCIslqkaetedgRWYPEFFRINFsrCIFCGLCEEACPTTAIQL 118
Cdd:cd16370  70 LEPRKGGGVVLDKE-----KCIGCGNCVKACIVGAI----------FWDEETNKPII--CIHCGYCARYCPHDVLAM 129
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 93-131 2.37e-03

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 35.07  E-value: 2.37e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15597840  93 FFRINFSRCIFCGLCEEACPTTAIQLTPDFEMGEFKRQD 131
Cdd:COG1146   2 MPVIDTDKCIGCGACVEVCPVDVLELDEEGKKALVINPE 40
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 54-118 2.60e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 36.52  E-value: 2.60e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597840  54 RDPDGE----ERCVACNLCAVACPVGCISLQKAetedgrwypeffrinfSRCIFCG-----LCEEACPTTAIQL 118
Cdd:cd16367  76 RDDGGEvvisDACCGCGNCASACPYGAIQMVRA----------------VKCDLCAgyagpACVSACPTGAAIR 133
RnfC COG4656
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and ...
 50-112 2.61e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 443694 [Multi-domain]  Cd Length: 451  Bit Score: 37.43  E-value: 2.61e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597840  50 IVLTRD--PDGEER-CVACNLCAVACPVGCISLQKAETEDGRWYPEFFRINFSRCIFCGLCEEACP 112
Cdd:COG4656 351 LALTKEevPPPEEQpCIRCGRCVDACPMGLLPQQLYWYARAGDFDKAEEYNLMDCIECGCCSYVCP 416
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 59-124 3.05e-03

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 36.51  E-value: 3.05e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597840  59 EERCVACNLCAVACPVGCIslqkaetedgRWYPEFFRINfsRCIFC------GL---CEEACPTTAIQLTPDFEM 124
Cdd:cd10562  99 EDKCIGCGYCVAACPFDVP----------RYDETTNKIT--KCTLCfdrienGMqpaCVKTCPTGALTFGDRDEL 161
GlpC COG0247
Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy ...
 60-112 3.84e-03

Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy production and conversion];


Pssm-ID: 440017 [Multi-domain]  Cd Length: 420  Bit Score: 36.98  E-value: 3.84e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15597840  60 ERCVACNLCAVACPV------------GCISLQKA--ETEDGRWYPEFFRINFSRCIFCGLCEEACP 112
Cdd:COG0247  78 DACVGCGFCRAMCPSykatgdekdsprGRINLLREvlEGELPLDLSEEVYEVLDLCLTCKACETACP 144
RNAP_D cd07030
D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is ...
 60-121 4.89e-03

D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. A single distinct RNAP complex is found in archaea, which may be responsible for the synthesis of all RNAs. The archaeal RNAP harbors homologues of all eukaryotic RNAP II subunits with two exceptions (RPB8 and RPB9). The 12 archaeal subunits are designated by letters and can be divided into three functional groups that are engaged in: (I) catalysis (A'/A", B'/B" or B); (II) assembly (L, N, D and P); and (III) auxiliary functions (F, E, H and K). The D subunit is equivalent to the RPB3 subunit of eukaryotic RNAP II. It contains two subdomains: one subdomain is similar the eukaryotic Rpb11/AC19/archaeal L subunit which is involved in dimerization, and the other is an inserted beta sheet subdomain. The assembly of the two largest archaeal RNAP subunits that provide most of the enzyme's catalytic functions depends on the presence of the archaeal D/L heterodimer.


Pssm-ID: 132908 [Multi-domain]  Cd Length: 259  Bit Score: 36.48  E-value: 4.89e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597840  60 ERCVACNLCAVACPVGCISLQKAETEDGRWYPeffrinfsrCIFCGLCEEACPTTAIQLTPD 121
Cdd:cd07030 169 EDCDGCGKCVEECPRGVLELEEGKVVVEDLED---------CSLCKLCERACDAGAIRVGWD 221
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 59-86 4.98e-03

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 34.32  E-value: 4.98e-03
                        10        20
                ....*....|....*....|....*...
gi 15597840  59 EERCVACNLCAVACPVGCISLQKAETED 86
Cdd:COG1149  40 PDLCTGCGACVGVCPTGAITLEEREAGK 67
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 62-124 7.25e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 34.94  E-value: 7.25e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597840  62 CVACNL--CAVACPVGCISLQKaeteDGRwypefFRINFSRCIFCGLCEEACPTTAIQLTPDFEM 124
Cdd:cd16370  53 CRACEDppCAEACPTGALEPRK----GGG-----VVLDKEKCIGCGNCVKACIVGAIFWDEETNK 108
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
91-121 9.48e-03

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 35.99  E-value: 9.48e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 15597840  91 PEFFRINFSRCIFCGLCEEACPTTAIQLTPD 121
Cdd:COG1148 488 PSVAEVDPEKCTGCGRCVEVCPYGAISIDEK 518
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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