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Conserved domains on  [gi|15597953|ref|NP_251447|]
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hypothetical protein PA2757 [Pseudomonas aeruginosa PAO1]

Protein Classification

COG4125 family protein( domain architecture ID 11467892)

COG4125 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PACE_transport NF033664
PACE efflux transporter; PACE transporters, including the chlorhexidine efflux transporter ...
 3-133 1.16e-61

PACE efflux transporter; PACE transporters, including the chlorhexidine efflux transporter AceI, average about 140 amino acids in length and consist of two tandem homologous domains described by Pfam model PF05232. PACE transporters are single component efflux transporters that sit in the plasma membrane and couple proton import to substrate export.


:

Pssm-ID: 411267 [Multi-domain]  Cd Length: 130  Bit Score: 185.45  E-value: 1.16e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597953    3 GIKRKLVYVTAYELIGMSISTLGLALLAGSTPTTTGPLAVVITTVAVTWNFIYNCLFEFWERRQAVRGRSiARRVAHAIG 82
Cdd:NF033664   1 GLKERIVHAVLFEVIAILISAPLLAWLMGRSLSHSGALAVMISTIAMLWNMIYNALFERWERRQRVRRRT-VRRVLHAIG 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15597953   83 FQLTLVVYLIPLIAWWMGISLLEAFWLDLALIVLIPCYTFLFNWAFDRLFG 133
Cdd:NF033664  80 FEGGLVLILVPLAAWWLGISLLEAFLLDIGLLLFFLPYTFVFNWAFDKLRG 130
 
Name Accession Description Interval E-value
PACE_transport NF033664
PACE efflux transporter; PACE transporters, including the chlorhexidine efflux transporter ...
 3-133 1.16e-61

PACE efflux transporter; PACE transporters, including the chlorhexidine efflux transporter AceI, average about 140 amino acids in length and consist of two tandem homologous domains described by Pfam model PF05232. PACE transporters are single component efflux transporters that sit in the plasma membrane and couple proton import to substrate export.


Pssm-ID: 411267 [Multi-domain]  Cd Length: 130  Bit Score: 185.45  E-value: 1.16e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597953    3 GIKRKLVYVTAYELIGMSISTLGLALLAGSTPTTTGPLAVVITTVAVTWNFIYNCLFEFWERRQAVRGRSiARRVAHAIG 82
Cdd:NF033664   1 GLKERIVHAVLFEVIAILISAPLLAWLMGRSLSHSGALAVMISTIAMLWNMIYNALFERWERRQRVRRRT-VRRVLHAIG 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15597953   83 FQLTLVVYLIPLIAWWMGISLLEAFWLDLALIVLIPCYTFLFNWAFDRLFG 133
Cdd:NF033664  80 FEGGLVLILVPLAAWWLGISLLEAFLLDIGLLLFFLPYTFVFNWAFDKLRG 130
COG4125 COG4125
Uncharacterized membrane protein [Function unknown];
1-144 1.03e-59

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 443301  Cd Length: 144  Bit Score: 181.19  E-value: 1.03e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597953   1 MQGIKRKLVYVTAYELIGMSISTLGLALLAGSTPTTTGPLAVVITTVAVTWNFIYNCLFEFWERRQAVRGRSIARRVAHA 80
Cdd:COG4125   1 MRSLKERIRHAVLFELIALLISAPLLAWLFGKSLGDMGALAVVLSTIAMLWNYIYNWLFDRWERRQRGVRRTLRVRILHA 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597953  81 IGFQLTLVVYLIPLIAWWMGISLLEAFWLDLALIVLIPCYTFLFNWAFDRLFGLPTSALPAGEA 144
Cdd:COG4125  81 LGFEGGLLLILVPLIAWWLGISLWEALLLDIGLLLFFLVYTFVFNWAYDRLFPLPRSARAAAAA 144
PACE_efflu_PCE NF033665
multidrug/biocide efflux PACE transporter; PACE (proteobacterial antimicrobial compound efflux) ...
 4-131 1.69e-30

multidrug/biocide efflux PACE transporter; PACE (proteobacterial antimicrobial compound efflux) transporters are single component proton-coupled efflux pumps that help confer resistance to a number of biocides and antibiotics. The family has also been named PCE (proteobacterial chlorhexidine efflux). Members of this subfamily of the PACE transporters, distinct from the AceI-like branch, include several whose expression is increased by exposure to chlorhexidine and/or help confer increased resistance to it.


Pssm-ID: 411268  Cd Length: 130  Bit Score: 106.55  E-value: 1.69e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597953    4 IKRKLVYVTAYELIGMSISTLGLALLAGSTPTTTGPLAVVITTVAVTWNFIYNCLFEFWERRQAVRgRSIARRVAHAIGF 83
Cdd:NF033665   2 LTERIFHAVGFEGIAVLICAPLLAWLMDRSLLEMGALTIMLSTVAMLWNMIYNALFDRLWPRLGVA-RTLKVRVLHALGF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 15597953   84 QLTLVVYLIPLIAWWMGISLLEAFWLDLALIVLIPCYTFLFNWAFDRL 131
Cdd:NF033665  81 EGGLILIGVPLAAWWLGISLLQAFLLEIGFFLFFLPYTMVYNWAYDKL 128
BTP pfam05232
Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane ...
 71-134 1.97e-19

Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane alpha-helices. All members carry the two pairs of TMs. BTP is a form of drug efflux pump, that actively tranports chlorhexidine out of the cell. Chlorhexidine, a bisbiguanide antimicrobial agent, is commonly used as an antiseptic and disinfectant in hospitals, and there is an increasing problem with resistance to it in some pathogenic bacteria. BTP is localized in the cytoplasmic membrane.


Pssm-ID: 428384  Cd Length: 64  Bit Score: 76.38  E-value: 1.97e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597953    71 RSIARRVAHAIGFQLTLVVYLIPLIAWWMGISLLEAFWLDLALIVLIPCYTFLFNWAFDRLFGL 134
Cdd:pfam05232   1 RSLKRRVLHALLFELGLLLLLVPLLAWLLGVSLGEAGVLDIGLSLFAMVWNFVFNWLFDRLFPR 64
 
Name Accession Description Interval E-value
PACE_transport NF033664
PACE efflux transporter; PACE transporters, including the chlorhexidine efflux transporter ...
 3-133 1.16e-61

PACE efflux transporter; PACE transporters, including the chlorhexidine efflux transporter AceI, average about 140 amino acids in length and consist of two tandem homologous domains described by Pfam model PF05232. PACE transporters are single component efflux transporters that sit in the plasma membrane and couple proton import to substrate export.


Pssm-ID: 411267 [Multi-domain]  Cd Length: 130  Bit Score: 185.45  E-value: 1.16e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597953    3 GIKRKLVYVTAYELIGMSISTLGLALLAGSTPTTTGPLAVVITTVAVTWNFIYNCLFEFWERRQAVRGRSiARRVAHAIG 82
Cdd:NF033664   1 GLKERIVHAVLFEVIAILISAPLLAWLMGRSLSHSGALAVMISTIAMLWNMIYNALFERWERRQRVRRRT-VRRVLHAIG 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15597953   83 FQLTLVVYLIPLIAWWMGISLLEAFWLDLALIVLIPCYTFLFNWAFDRLFG 133
Cdd:NF033664  80 FEGGLVLILVPLAAWWLGISLLEAFLLDIGLLLFFLPYTFVFNWAFDKLRG 130
COG4125 COG4125
Uncharacterized membrane protein [Function unknown];
1-144 1.03e-59

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 443301  Cd Length: 144  Bit Score: 181.19  E-value: 1.03e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597953   1 MQGIKRKLVYVTAYELIGMSISTLGLALLAGSTPTTTGPLAVVITTVAVTWNFIYNCLFEFWERRQAVRGRSIARRVAHA 80
Cdd:COG4125   1 MRSLKERIRHAVLFELIALLISAPLLAWLFGKSLGDMGALAVVLSTIAMLWNYIYNWLFDRWERRQRGVRRTLRVRILHA 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597953  81 IGFQLTLVVYLIPLIAWWMGISLLEAFWLDLALIVLIPCYTFLFNWAFDRLFGLPTSALPAGEA 144
Cdd:COG4125  81 LGFEGGLLLILVPLIAWWLGISLWEALLLDIGLLLFFLVYTFVFNWAYDRLFPLPRSARAAAAA 144
PACE_efflu_PCE NF033665
multidrug/biocide efflux PACE transporter; PACE (proteobacterial antimicrobial compound efflux) ...
 4-131 1.69e-30

multidrug/biocide efflux PACE transporter; PACE (proteobacterial antimicrobial compound efflux) transporters are single component proton-coupled efflux pumps that help confer resistance to a number of biocides and antibiotics. The family has also been named PCE (proteobacterial chlorhexidine efflux). Members of this subfamily of the PACE transporters, distinct from the AceI-like branch, include several whose expression is increased by exposure to chlorhexidine and/or help confer increased resistance to it.


Pssm-ID: 411268  Cd Length: 130  Bit Score: 106.55  E-value: 1.69e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597953    4 IKRKLVYVTAYELIGMSISTLGLALLAGSTPTTTGPLAVVITTVAVTWNFIYNCLFEFWERRQAVRgRSIARRVAHAIGF 83
Cdd:NF033665   2 LTERIFHAVGFEGIAVLICAPLLAWLMDRSLLEMGALTIMLSTVAMLWNMIYNALFDRLWPRLGVA-RTLKVRVLHALGF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 15597953   84 QLTLVVYLIPLIAWWMGISLLEAFWLDLALIVLIPCYTFLFNWAFDRL 131
Cdd:NF033665  81 EGGLILIGVPLAAWWLGISLLQAFLLEIGFFLFFLPYTMVYNWAYDKL 128
BTP pfam05232
Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane ...
 71-134 1.97e-19

Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane alpha-helices. All members carry the two pairs of TMs. BTP is a form of drug efflux pump, that actively tranports chlorhexidine out of the cell. Chlorhexidine, a bisbiguanide antimicrobial agent, is commonly used as an antiseptic and disinfectant in hospitals, and there is an increasing problem with resistance to it in some pathogenic bacteria. BTP is localized in the cytoplasmic membrane.


Pssm-ID: 428384  Cd Length: 64  Bit Score: 76.38  E-value: 1.97e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597953    71 RSIARRVAHAIGFQLTLVVYLIPLIAWWMGISLLEAFWLDLALIVLIPCYTFLFNWAFDRLFGL 134
Cdd:pfam05232   1 RSLKRRVLHALLFELGLLLLLVPLLAWLLGVSLGEAGVLDIGLSLFAMVWNFVFNWLFDRLFPR 64
BTP pfam05232
Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane ...
 2-65 1.27e-11

Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane alpha-helices. All members carry the two pairs of TMs. BTP is a form of drug efflux pump, that actively tranports chlorhexidine out of the cell. Chlorhexidine, a bisbiguanide antimicrobial agent, is commonly used as an antiseptic and disinfectant in hospitals, and there is an increasing problem with resistance to it in some pathogenic bacteria. BTP is localized in the cytoplasmic membrane.


Pssm-ID: 428384  Cd Length: 64  Bit Score: 56.35  E-value: 1.27e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597953     2 QGIKRKLVYVTAYELIGMSISTLGLALLAGSTPTTTGPLAVVITTVAVTWNFIYNCLFEFWERR 65
Cdd:pfam05232   1 RSLKRRVLHALLFELGLLLLLVPLLAWLLGVSLGEAGVLDIGLSLFAMVWNFVFNWLFDRLFPR 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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