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Conserved domains on  [gi|15597958|ref|NP_251452|]
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hypothetical protein PA2762 [Pseudomonas aeruginosa PAO1]

Protein Classification

cupin domain-containing protein( domain architecture ID 10007407)

cupin domain-containing protein, part of a functionally diverse superfamily with the active site generally located at the center of a conserved domain forming a beta-barrel fold

CATH:  2.60.120.10
Gene Ontology:  GO:0046872
PubMed:  19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3450 COG3450
Predicted enzyme of the cupin superfamily [General function prediction only];
9-113 1.87e-39

Predicted enzyme of the cupin superfamily [General function prediction only];


:

Pssm-ID: 442673  Cd Length: 108  Bit Score: 127.40  E-value: 1.87e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597958   9 RDTCPVPVLDATKWKRIDGDPHTVNLNAYASADGSKLMGTWICTPGKWEVNYERWEFCHFLDGYCIITPEGEQPVHLRAG 88
Cdd:COG3450   3 ADAVEPESDPPAPERILEGDPSARTWNLFTSPDGGVSAGVWECTPGKFRWDYDEDEFCYILEGRVTVTDDDGEPVEFGAG 82

                        90       100
                ....*....|....*....|....*
gi 15597958  89 DVFVIEPGLRGTWEVVETVRKYFVF 113
Cdd:COG3450  83 DSFVFPAGFKGTWEVLETVRKHYVI 107
 
Name Accession Description Interval E-value
COG3450 COG3450
Predicted enzyme of the cupin superfamily [General function prediction only];
9-113 1.87e-39

Predicted enzyme of the cupin superfamily [General function prediction only];


Pssm-ID: 442673  Cd Length: 108  Bit Score: 127.40  E-value: 1.87e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597958   9 RDTCPVPVLDATKWKRIDGDPHTVNLNAYASADGSKLMGTWICTPGKWEVNYERWEFCHFLDGYCIITPEGEQPVHLRAG 88
Cdd:COG3450   3 ADAVEPESDPPAPERILEGDPSARTWNLFTSPDGGVSAGVWECTPGKFRWDYDEDEFCYILEGRVTVTDDDGEPVEFGAG 82

                        90       100
                ....*....|....*....|....*
gi 15597958  89 DVFVIEPGLRGTWEVVETVRKYFVF 113
Cdd:COG3450  83 DSFVFPAGFKGTWEVLETVRKHYVI 107
cupin_TM1112-like cd02227
Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial ...
 46-113 4.20e-34

Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial and plant proteins homologous to TM1112, a Thermotoga maritima protein of unknown function with a cupin beta barrel domain. TM1112 (also known as DUF861) is a subfamily of RmlC-like cupins with a conserved "jelly roll-like" beta-barrel fold; structures indicate that a monomer is the biologically-relevant form.


Pssm-ID: 380356 [Multi-domain]  Cd Length: 69  Bit Score: 112.67  E-value: 4.20e-34
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597958  46 MGTWICTPGKWEVNYERWEFCHFLDGYCIITPEGEQPVHLRAGDVFVIEPGLRGTWEVVETVRKYFVF 113
Cdd:cd02227   2 WGIWECTPGKFPWNYDEDEFCYILEGEVRVTPEDGEPVTFKAGDLVVFPAGFSGTWEVLEPVRKHYVF 69
Cupin_3 pfam05899
EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly ...
 39-111 2.07e-30

EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly roll-like beta-barrel fold capable of homodimerization found in bacteria, plant and fungi. It is present in EutQ family from the eut operon, involved in ethanolamine degradation. EutQ is essential during anoxic growth and has acetate kinase activity. The cupin domain from EutQ does not possess the His residues responsible for metal coordination in other classes of cupins. This domain is also found in (S)-ureidoglycine aminohydrolase (UGlyAH) from E.coli, which is involved in the anaerobic nitrogen utilization via the assimilation of allantoin. It catalyzes the deamination of allantoin to produce S-ureidoglycolate and ammonia from S-ureidoglycine.


Pssm-ID: 399116 [Multi-domain]  Cd Length: 74  Bit Score: 103.14  E-value: 2.07e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597958    39 SADGSKLMGTWICTPGKWEVNYERWEFCHFLDGYCIITPEGEQPVHLRAGDVFVIEPGLRGTWEVVETVRKYF 111
Cdd:pfam05899   2 SPLGVFSWGIWECTPGKFRWTYEEDETCYILSGEVTVTPEGGKTVTLRAGDLVVLPKGLSGTWDVLETVRKHY 74
 
Name Accession Description Interval E-value
COG3450 COG3450
Predicted enzyme of the cupin superfamily [General function prediction only];
9-113 1.87e-39

Predicted enzyme of the cupin superfamily [General function prediction only];


Pssm-ID: 442673  Cd Length: 108  Bit Score: 127.40  E-value: 1.87e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597958   9 RDTCPVPVLDATKWKRIDGDPHTVNLNAYASADGSKLMGTWICTPGKWEVNYERWEFCHFLDGYCIITPEGEQPVHLRAG 88
Cdd:COG3450   3 ADAVEPESDPPAPERILEGDPSARTWNLFTSPDGGVSAGVWECTPGKFRWDYDEDEFCYILEGRVTVTDDDGEPVEFGAG 82

                        90       100
                ....*....|....*....|....*
gi 15597958  89 DVFVIEPGLRGTWEVVETVRKYFVF 113
Cdd:COG3450  83 DSFVFPAGFKGTWEVLETVRKHYVI 107
cupin_TM1112-like cd02227
Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial ...
 46-113 4.20e-34

Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial and plant proteins homologous to TM1112, a Thermotoga maritima protein of unknown function with a cupin beta barrel domain. TM1112 (also known as DUF861) is a subfamily of RmlC-like cupins with a conserved "jelly roll-like" beta-barrel fold; structures indicate that a monomer is the biologically-relevant form.


Pssm-ID: 380356 [Multi-domain]  Cd Length: 69  Bit Score: 112.67  E-value: 4.20e-34
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597958  46 MGTWICTPGKWEVNYERWEFCHFLDGYCIITPEGEQPVHLRAGDVFVIEPGLRGTWEVVETVRKYFVF 113
Cdd:cd02227   2 WGIWECTPGKFPWNYDEDEFCYILEGEVRVTPEDGEPVTFKAGDLVVFPAGFSGTWEVLEPVRKHYVF 69
Cupin_3 pfam05899
EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly ...
 39-111 2.07e-30

EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly roll-like beta-barrel fold capable of homodimerization found in bacteria, plant and fungi. It is present in EutQ family from the eut operon, involved in ethanolamine degradation. EutQ is essential during anoxic growth and has acetate kinase activity. The cupin domain from EutQ does not possess the His residues responsible for metal coordination in other classes of cupins. This domain is also found in (S)-ureidoglycine aminohydrolase (UGlyAH) from E.coli, which is involved in the anaerobic nitrogen utilization via the assimilation of allantoin. It catalyzes the deamination of allantoin to produce S-ureidoglycolate and ammonia from S-ureidoglycine.


Pssm-ID: 399116 [Multi-domain]  Cd Length: 74  Bit Score: 103.14  E-value: 2.07e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597958    39 SADGSKLMGTWICTPGKWEVNYERWEFCHFLDGYCIITPEGEQPVHLRAGDVFVIEPGLRGTWEVVETVRKYF 111
Cdd:pfam05899   2 SPLGVFSWGIWECTPGKFRWTYEEDETCYILSGEVTVTPEGGKTVTLRAGDLVVLPKGLSGTWDVLETVRKHY 74
cupin_BLL4011-like cd02235
Bradyrhizobium diazoefficiens BLL4011 and related proteins, cupin domain; This family includes ...
 64-96 2.90e-03

Bradyrhizobium diazoefficiens BLL4011 and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to BLL4011, a Bradyrhizobium diazoefficiens protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380363 [Multi-domain]  Cd Length: 100  Bit Score: 34.48  E-value: 2.90e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 15597958  64 EFCHFLDGYCIITPEGEQPVHLRAGDVFVIEPG 96
Cdd:cd02235  41 ESGYVLEGSLELEVDGQPPVTLKAGDSFFIPAG 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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