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Conserved domains on  [gi|15598101|ref|NP_251595|]
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precorrin-8X methylmutase [Pseudomonas aeruginosa PAO1]

Protein Classification

precorrin-8X methylmutase( domain architecture ID 10013033)

precorrin-8X methylmutase (cobH ) catalyzes the interconversion of precorrin-8X and hydrogenobyrinate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
cobH PRK08285
precorrin-8X methylmutase; Reviewed
1-193 4.82e-120

precorrin-8X methylmutase; Reviewed


:

Pssm-ID: 181352  Cd Length: 208  Bit Score: 338.78  E-value: 4.82e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101    1 MIDYIRDGQAIYRQSFATIRAEANLAGIPADLEKLAVRVIHACGMVDVVDDLRFSPGAGAAGRAALAAGAAILCDARMVA 80
Cdd:PRK08285   1 MLDYIRDGAEIYRQSFATIRAEADLSRFPADLEKVAVRMIHACGMVDVADDLAFSPGAVAAARAALAAGAPILCDARMVA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101   81 EGVTRSRLPAANRVICTLNEADVPALATELGNTRSAVALEHWREHLEGSVVVIGNAPTALFYLLEMLDAGAPKPALILGF 160
Cdd:PRK08285  81 EGITRARLPADNEVICTLRDPRVPELAAELGNTRSAAALELWRPRLAGSVVAIGNAPTALFRLLEMLDAGAPRPAAILGF 160
                        170       180       190
                 ....*....|....*....|....*....|...
gi 15598101  161 PVGFVGAAESKEMLAADSRGVPYVIVRGRRGGS 193
Cdd:PRK08285 161 PVGFVGAAESKDALAADSRGVPYLIVRGRRGGS 193
 
Name Accession Description Interval E-value
cobH PRK08285
precorrin-8X methylmutase; Reviewed
1-193 4.82e-120

precorrin-8X methylmutase; Reviewed


Pssm-ID: 181352  Cd Length: 208  Bit Score: 338.78  E-value: 4.82e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101    1 MIDYIRDGQAIYRQSFATIRAEANLAGIPADLEKLAVRVIHACGMVDVVDDLRFSPGAGAAGRAALAAGAAILCDARMVA 80
Cdd:PRK08285   1 MLDYIRDGAEIYRQSFATIRAEADLSRFPADLEKVAVRMIHACGMVDVADDLAFSPGAVAAARAALAAGAPILCDARMVA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101   81 EGVTRSRLPAANRVICTLNEADVPALATELGNTRSAVALEHWREHLEGSVVVIGNAPTALFYLLEMLDAGAPKPALILGF 160
Cdd:PRK08285  81 EGITRARLPADNEVICTLRDPRVPELAAELGNTRSAAALELWRPRLAGSVVAIGNAPTALFRLLEMLDAGAPRPAAILGF 160
                        170       180       190
                 ....*....|....*....|....*....|...
gi 15598101  161 PVGFVGAAESKEMLAADSRGVPYVIVRGRRGGS 193
Cdd:PRK08285 161 PVGFVGAAESKDALAADSRGVPYLIVRGRRGGS 193
CobH COG2082
Precorrin-8X methylmutase CbiC/CobH [Coenzyme transport and metabolism]; Precorrin-8X ...
3-193 5.82e-97

Precorrin-8X methylmutase CbiC/CobH [Coenzyme transport and metabolism]; Precorrin-8X methylmutase CbiC/CobH is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441685  Cd Length: 203  Bit Score: 280.39  E-value: 5.82e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101   3 DYIRDGQAIYRQSFATIRAEANLAGIPADLEKLAVRVIHACGMVDVVDDLRFSPGAGAAGRAALAAGAAILCDARMVAEG 82
Cdd:COG2082   1 DYIRDPAEIERESFAIIRAELDLSRFSEDEEPVVVRLIHATGDFDLADLLRFSPGAVEAGRAALRAGAPIVTDVEMVAAG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101  83 VTRSRLPA-ANRVICTLNEADVPALATELGNTRSAVALEHWREHLEGSVVVIGNAPTALFYLLEMLDAGAPKPALILGFP 161
Cdd:COG2082  81 INKRRLPAlGNEVICLISDPRVAELAKAEGITRSAAAMRLAAERLEGAIVAIGNAPTALFELLELIEEGAPRPALIIGVP 160
                       170       180       190
                ....*....|....*....|....*....|..
gi 15598101 162 VGFVGAAESKEMLAAdsRGVPYVIVRGRRGGS 193
Cdd:COG2082 161 VGFVGAAESKEALMA--SGVPYITVRGRKGGS 190
CbiC pfam02570
Precorrin-8X methylmutase; This is a family Precorrin-8X methylmutases also known as Precorrin ...
11-193 2.89e-80

Precorrin-8X methylmutase; This is a family Precorrin-8X methylmutases also known as Precorrin isomerase, CbiC/CobH, EC:5.4.1.2. This enzyme catalyzes the reaction: Precorrin-8X <=> hydrogenobyrinate. This enzyme is part of the Cobalamin (vitamin B12) biosynthetic pathway and catalyzes a methyl rearrangement.


Pssm-ID: 426840  Cd Length: 195  Bit Score: 237.67  E-value: 2.89e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101    11 IYRQSFATIRAEANLAGIPADLEKLAVRVIHACGMVDVVDDLRFSPGAGAAGRAALAAGAAILCDARMVAEGVTRSRLPA 90
Cdd:pfam02570   1 IEAESFAIIDEELGLHRFSPAEYEIVRRVIHATGDFEYADLLRFSPGAVEAGRAALKAGAPIVTDVNMVAAGINKRRLAT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101    91 -ANRVICTLNEADVPALATELGNTRSAVALEHWREHLEGSVVVIGNAPTALFYLLEMLDAGAPKPALILGFPVGFVGAAE 169
Cdd:pfam02570  81 fGNPVYCFLDDPEVAELAKERGITRSAAAMELAAERLPGAIVVIGNAPTALFELLELIEEGKIRPALVIGVPVGFVGAAE 160
                         170       180
                  ....*....|....*....|....
gi 15598101   170 SKEMLAAdsRGVPYVIVRGRRGGS 193
Cdd:pfam02570 161 SKEALAA--SGVPYITVRGRKGGS 182
 
Name Accession Description Interval E-value
cobH PRK08285
precorrin-8X methylmutase; Reviewed
1-193 4.82e-120

precorrin-8X methylmutase; Reviewed


Pssm-ID: 181352  Cd Length: 208  Bit Score: 338.78  E-value: 4.82e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101    1 MIDYIRDGQAIYRQSFATIRAEANLAGIPADLEKLAVRVIHACGMVDVVDDLRFSPGAGAAGRAALAAGAAILCDARMVA 80
Cdd:PRK08285   1 MLDYIRDGAEIYRQSFATIRAEADLSRFPADLEKVAVRMIHACGMVDVADDLAFSPGAVAAARAALAAGAPILCDARMVA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101   81 EGVTRSRLPAANRVICTLNEADVPALATELGNTRSAVALEHWREHLEGSVVVIGNAPTALFYLLEMLDAGAPKPALILGF 160
Cdd:PRK08285  81 EGITRARLPADNEVICTLRDPRVPELAAELGNTRSAAALELWRPRLAGSVVAIGNAPTALFRLLEMLDAGAPRPAAILGF 160
                        170       180       190
                 ....*....|....*....|....*....|...
gi 15598101  161 PVGFVGAAESKEMLAADSRGVPYVIVRGRRGGS 193
Cdd:PRK08285 161 PVGFVGAAESKDALAADSRGVPYLIVRGRRGGS 193
CobH COG2082
Precorrin-8X methylmutase CbiC/CobH [Coenzyme transport and metabolism]; Precorrin-8X ...
3-193 5.82e-97

Precorrin-8X methylmutase CbiC/CobH [Coenzyme transport and metabolism]; Precorrin-8X methylmutase CbiC/CobH is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441685  Cd Length: 203  Bit Score: 280.39  E-value: 5.82e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101   3 DYIRDGQAIYRQSFATIRAEANLAGIPADLEKLAVRVIHACGMVDVVDDLRFSPGAGAAGRAALAAGAAILCDARMVAEG 82
Cdd:COG2082   1 DYIRDPAEIERESFAIIRAELDLSRFSEDEEPVVVRLIHATGDFDLADLLRFSPGAVEAGRAALRAGAPIVTDVEMVAAG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101  83 VTRSRLPA-ANRVICTLNEADVPALATELGNTRSAVALEHWREHLEGSVVVIGNAPTALFYLLEMLDAGAPKPALILGFP 161
Cdd:COG2082  81 INKRRLPAlGNEVICLISDPRVAELAKAEGITRSAAAMRLAAERLEGAIVAIGNAPTALFELLELIEEGAPRPALIIGVP 160
                       170       180       190
                ....*....|....*....|....*....|..
gi 15598101 162 VGFVGAAESKEMLAAdsRGVPYVIVRGRRGGS 193
Cdd:COG2082 161 VGFVGAAESKEALMA--SGVPYITVRGRKGGS 190
CbiC pfam02570
Precorrin-8X methylmutase; This is a family Precorrin-8X methylmutases also known as Precorrin ...
11-193 2.89e-80

Precorrin-8X methylmutase; This is a family Precorrin-8X methylmutases also known as Precorrin isomerase, CbiC/CobH, EC:5.4.1.2. This enzyme catalyzes the reaction: Precorrin-8X <=> hydrogenobyrinate. This enzyme is part of the Cobalamin (vitamin B12) biosynthetic pathway and catalyzes a methyl rearrangement.


Pssm-ID: 426840  Cd Length: 195  Bit Score: 237.67  E-value: 2.89e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101    11 IYRQSFATIRAEANLAGIPADLEKLAVRVIHACGMVDVVDDLRFSPGAGAAGRAALAAGAAILCDARMVAEGVTRSRLPA 90
Cdd:pfam02570   1 IEAESFAIIDEELGLHRFSPAEYEIVRRVIHATGDFEYADLLRFSPGAVEAGRAALKAGAPIVTDVNMVAAGINKRRLAT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101    91 -ANRVICTLNEADVPALATELGNTRSAVALEHWREHLEGSVVVIGNAPTALFYLLEMLDAGAPKPALILGFPVGFVGAAE 169
Cdd:pfam02570  81 fGNPVYCFLDDPEVAELAKERGITRSAAAMELAAERLPGAIVVIGNAPTALFELLELIEEGKIRPALVIGVPVGFVGAAE 160
                         170       180
                  ....*....|....*....|....
gi 15598101   170 SKEMLAAdsRGVPYVIVRGRRGGS 193
Cdd:pfam02570 161 SKEALAA--SGVPYITVRGRKGGS 182
cbiC PRK05575
precorrin-8X methylmutase; Validated
2-193 4.38e-35

precorrin-8X methylmutase; Validated


Pssm-ID: 180140  Cd Length: 204  Bit Score: 122.98  E-value: 4.38e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101    2 IDYIRDGQAIYRQSFATIRAEANLAGIPADLEKLAVRVIHACGMVDVVDDLRFSPGAGAAGRAALAAGAAILCDARMVAE 81
Cdd:PRK05575   1 MDYIKKPMGIEKRSFEIIGEEMGEHNFSEEELKIVKRVIHTTADFEYKDLIYIREGAIEAAKEILKKGTKIYTDTNMALS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101   82 GVTRSRLPAAN-RVICTLNEADVPALATELGNTRSAVALEHWREhlEG-SVVVIGNAPTALFYLLEMLDAGAPKPALILG 159
Cdd:PRK05575  81 GINKKALKKLNsTVQCYVSREEVAKIAKERGITRSMAAVEKAAE--EGvEFFVFGNAPTALYKLKELIKEGKANPKFIIA 158
                        170       180       190
                 ....*....|....*....|....*....|....
gi 15598101  160 FPVGFVGAAESKEMLaaDSRGVPYVIVRGRRGGS 193
Cdd:PRK05575 159 VPVGFVGAAESKEEL--EKLDIPYITVRGRKGGS 190
cbiC PRK08286
cobalt-precorrin-8 methylmutase;
3-193 2.60e-30

cobalt-precorrin-8 methylmutase;


Pssm-ID: 181353  Cd Length: 214  Bit Score: 110.92  E-value: 2.60e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101    3 DYIRDGQAIYRQSFATI-------RAEANLAGipADLEKLAVRVIHACGMVDVVDDLRFSPGAGAAGRAALAAGAAILCD 75
Cdd:PRK08286   2 NYIQQPQKIEEKSFEIIqeiidetRPDYRFAS--PLEEAIIKRVIHTTADFDWLDILWFSPDALEKIIDALRNPCTIYTD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101   76 ARMVAEGVTRSRLPA-ANRVICTLNEADVPALATELGNTRSAVALEHWREHLEGSVVVIGNAPTALFYLLEMLDAGAPKP 154
Cdd:PRK08286  80 TTMALSGINKRLLDTlGCEYRCYISDPRVVELAKEQGITRSMAAVDIAAAEEGPKLFVFGNAPTALFRLLEMVEHGQLQV 159
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 15598101  155 ALILGFPVGFVGAAESKEMLAADsrGVPYVIVRGRRGGS 193
Cdd:PRK08286 160 DAVVGVPVGFVGAAESKEALTES--DLPAIAALGRKGGS 196
PRK05954 PRK05954
precorrin-8X methylmutase; Provisional
11-193 6.86e-30

precorrin-8X methylmutase; Provisional


Pssm-ID: 180326  Cd Length: 203  Bit Score: 109.37  E-value: 6.86e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101   11 IYRQSFATIRAEA---NLAGIPAdleKLAVRVIHACGMVDVVDDLRFSPGAGAAGRAALAAGAAILCDARMVAEGVTRS- 86
Cdd:PRK05954   8 ILEQSFAIIDQEIgphNFSPLEY---AIARRVIHSTADFEFINLLRFSPNAIAAGLAALRQKTPIITDVTMVKQGIQTLv 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101   87 RLPAANRVICTLNEADVPALatelGNTRSAVA-LEHWREHLEGsVVVIGNAPTALFYLLEMLDAGAPKPALILGFPVGFV 165
Cdd:PRK05954  85 NKTFQNPIITAIDQVSIPLP----GKTRTETGlLKCAQQYPEA-IYVIGNAPTALLALCQQIRAGRVKPSLVIGVPVGFV 159
                        170       180
                 ....*....|....*....|....*...
gi 15598101  166 GAAESKEMLAadSRGVPYVIVRGRRGGS 193
Cdd:PRK05954 160 SVVEAKQALA--QLDVPQIRVEGRKGGS 185
cbiC PRK06264
cobalt-precorrin-8 methylmutase;
38-193 6.29e-28

cobalt-precorrin-8 methylmutase;


Pssm-ID: 235759  Cd Length: 210  Bit Score: 104.40  E-value: 6.29e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101   38 RVIHACGMVDVVDDLRFSPGAGAAGRAALAAGAAILCDARMVAEGVTRsrlpaaNRVICTLNEADVPALATELGNTRSAV 117
Cdd:PRK06264  44 RVVHATADPEYAKLVVFSNDPIEEGLDAIKDKKPIIVDINMVKAGIRY------NNVYCFISEPEVFELAKKEQITRAVA 117
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15598101  118 ALEHWREHLEGSVVVIGNAPTALFYLLEMLDAGAPKPALILGFPVGFVGAAESKEMLAadSRGVPYVIVRGRRGGS 193
Cdd:PRK06264 118 SMRLAKELIDGGIVVIGNAPTALFEVIRLVKEEGIKPKLVVGVPVGFVKAAESKEALR--NTNIPSISTIGPKGGT 191
PRK05782 PRK05782
bifunctional sirohydrochlorin cobalt chelatase/precorrin-8X methylmutase; Validated
3-193 1.04e-19

bifunctional sirohydrochlorin cobalt chelatase/precorrin-8X methylmutase; Validated


Pssm-ID: 235605 [Multi-domain]  Cd Length: 335  Bit Score: 85.24  E-value: 1.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101    3 DYIRDGQAIYRQSFATIRAEANLAGIPADLEKLAVRVIHACGMVDVVDDLRFSPGAGAAGRAALAAGAAILCDARMVAEG 82
Cdd:PRK05782 139 EYTEDPEEIEERSMNYILENLGLDVKDWREKRVIARAVYASGNLELAKYVKISNDLLDAGIEAIRAESEIVADVKMVSAG 218
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101   83 VTrsrlpaANRVICTLNEADVPALATELGNTRSAVALEHWREHlEGSVVVIGNAPTALFYLLEMLDAGAPKPaLILGFPV 162
Cdd:PRK05782 219 IR------WKKVTCMIDAERTKELAKELGITRAAAAMRLSLGQ-GGKVVVIGNAPTALIETLKLVKEGVDIP-FIVATPP 290
                        170       180       190
                 ....*....|....*....|....*....|.
gi 15598101  163 GFVGAAESKEMLAadSRGVPYVIVRGRRGGS 193
Cdd:PRK05782 291 GFTNAKEVKEALI--ESGIPSVVLRGTYGGS 319
PRK05953 PRK05953
Precorrin-8X methylmutase;
14-192 1.65e-15

Precorrin-8X methylmutase;


Pssm-ID: 180325  Cd Length: 208  Bit Score: 71.68  E-value: 1.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101   14 QSFATIRAEANLAGI-PADLEkLAVRVIHACGMVDVVDDLRFSPGAGAAGRAALAAGAAILCDARMVAEGVTRS-RLPAA 91
Cdd:PRK05953   9 QSLAIIDQEIGKHVLsPAEYE-IVRRVIYATADFEYLSLIRFSERALQAGAAALAARTTIVVDVPMVQVGIAPTlQNTFA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598101   92 NRVICTLNEADVPALAtelgNTRSAVALEHW-REHLEGsVVVIGNAPTALFYLLEMLDAGAPKPALILGFPVGFVGAAES 170
Cdd:PRK05953  88 NPVYCSTETITRPQKE----KTRTAWGIETLaRRYPEA-IFVIGQSQTALTALVELVEAEEIRPALVIATPAGFIDADDA 162
                        170       180
                 ....*....|....*....|..
gi 15598101  171 KEMLaADSrGVPYVIVRGRRGG 192
Cdd:PRK05953 163 KERL-QDS-LVPHITIDGRKGG 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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