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Conserved domains on  [gi|15598263|ref|NP_251757|]
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transcriptional regulator [Pseudomonas aeruginosa PAO1]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-128 3.64e-16

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 70.00  E-value: 3.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598263   2 PTNQDLQLAAHLRSQVTTLTRRLRREAQADPVQFSQLVVLGAIDRLGGdVTPSELAAAERMRSSNLAALLRELERGGLIV 81
Cdd:COG1846   5 PDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGG-LTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15598263  82 RHADPQDGRRTRVSLSSEGRRNLYGNRAKREEWLVRAMhACLDESER 128
Cdd:COG1846  84 REPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELL-AGLSEEEL 129
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-128 3.64e-16

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 70.00  E-value: 3.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598263   2 PTNQDLQLAAHLRSQVTTLTRRLRREAQADPVQFSQLVVLGAIDRLGGdVTPSELAAAERMRSSNLAALLRELERGGLIV 81
Cdd:COG1846   5 PDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGG-LTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15598263  82 RHADPQDGRRTRVSLSSEGRRNLYGNRAKREEWLVRAMhACLDESER 128
Cdd:COG1846  84 REPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELL-AGLSEEEL 129
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
26-128 1.46e-12

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 59.92  E-value: 1.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598263     26 REAQADPVQFSQLVVLGAIDRLGGdVTPSELAAAERMRSSNLAALLRELERGGLIVRHADPQDGRRTRVSLSSEGRRNLY 105
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGP-LSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIE 79

                           90       100
                   ....*....|....*....|...
gi 15598263    106 GNRAKREEWLVRAMHaCLDESER 128
Cdd:smart00347  80 QLLEARSETLAELLA-GLTAEEQ 101
HTH_27 pfam13463
Winged helix DNA-binding domain;
36-100 2.70e-06

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 42.66  E-value: 2.70e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598263    36 SQLVVLGAIDRLGGDVTPSELAAAERMRSSNLAALLRELERGGLIVRHADPQDGRRTRVSLSSEG 100
Cdd:pfam13463   4 LEALILHNIGHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
36-100 9.11e-04

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 37.18  E-value: 9.11e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15598263   36 SQLVVLGAIdRLGGDVTPSELaaaERMRSSNLAALLRELER---GGLIVRHADPQDGRRTRVSLSSEG 100
Cdd:PRK11512  41 AQFKVLCSI-RCAACITPVEL---KKVLSVDLGALTRMLDRlvcKGWVERLPNPNDKRGVLVKLTTSG 104
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-128 3.64e-16

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 70.00  E-value: 3.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598263   2 PTNQDLQLAAHLRSQVTTLTRRLRREAQADPVQFSQLVVLGAIDRLGGdVTPSELAAAERMRSSNLAALLRELERGGLIV 81
Cdd:COG1846   5 PDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGG-LTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15598263  82 RHADPQDGRRTRVSLSSEGRRNLYGNRAKREEWLVRAMhACLDESER 128
Cdd:COG1846  84 REPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELL-AGLSEEEL 129
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
26-128 1.46e-12

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 59.92  E-value: 1.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598263     26 REAQADPVQFSQLVVLGAIDRLGGdVTPSELAAAERMRSSNLAALLRELERGGLIVRHADPQDGRRTRVSLSSEGRRNLY 105
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGP-LSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIE 79

                           90       100
                   ....*....|....*....|...
gi 15598263    106 GNRAKREEWLVRAMHaCLDESER 128
Cdd:smart00347  80 QLLEARSETLAELLA-GLTAEEQ 101
HTH_27 pfam13463
Winged helix DNA-binding domain;
36-100 2.70e-06

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 42.66  E-value: 2.70e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598263    36 SQLVVLGAIDRLGGDVTPSELAAAERMRSSNLAALLRELERGGLIVRHADPQDGRRTRVSLSSEG 100
Cdd:pfam13463   4 LEALILHNIGHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 33-91 2.96e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 42.19  E-value: 2.96e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15598263    33 VQFSQLVVLGAIDRlGGDVTPSELAAAERMRSSNLAALLRELERGGLIVRHADPQDGRR 91
Cdd:pfam12802   3 LTPAQFRVLLALAR-NPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-90 2.77e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 36.76  E-value: 2.77e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15598263    36 SQLVVLGAIDRLGGdVTPSELAAAERMRSSNLAALLRELERGGLIVRHADPQDGR 90
Cdd:pfam01047   4 TQFHILRILYEHGP-LTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRR 57
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
36-100 9.11e-04

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 37.18  E-value: 9.11e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15598263   36 SQLVVLGAIdRLGGDVTPSELaaaERMRSSNLAALLRELER---GGLIVRHADPQDGRRTRVSLSSEG 100
Cdd:PRK11512  41 AQFKVLCSI-RCAACITPVEL---KKVLSVDLGALTRMLDRlvcKGWVERLPNPNDKRGVLVKLTTSG 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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