NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15598270|ref|NP_251764|]
View 

hypothetical protein PA3074 [Pseudomonas aeruginosa PAO1]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
VWA_2 pfam13519
von Willebrand factor type A domain;
108-198 3.69e-10

von Willebrand factor type A domain;


:

Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 57.30  E-value: 3.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270   108 MLAGDLSPTRLEQARRKLLDLLRTRNDAQTAIVVYAGSAHTLVPLSDDQLTARNLLDALKPSimpepGQRADL--AVRQA 185
Cdd:pfam13519  11 MRNGDYGPTRLEAAKDAVLALLKSLPGDRVGLVTFGDGPEVLIPLTKDRAKILRALRRLEPK-----GGGTNLaaALQLA 85

                          90
                  ....*....|...
gi 15598270   186 LDLLEQGAQGRGR 198
Cdd:pfam13519  86 RAALKHRRKNQPR 98
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 254-452 1.29e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.53  E-value: 1.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270 254 LLPRLDESGLRRFAAEIGAGYQRLRPNDRDLDSLGLLARGGTLEEDRENALLRLQRWADQGYWLLLPLLLLAACAGRRGw 333
Cdd:COG3914   4 AALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLE- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270 334 LFCLPLLMLSLPQPAMAFQFEDLWLRPD------QQGQRLLQRGQADEAAKRFEdfrwKGLSLYQARDYAaaaqafaqgd 407
Cdd:COG3914  83 LAALLLQALGRYEEALALYRRALALNPDnaealfNLGNLLLALGRLEEALAALR----RALALNPDFAEA---------- 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 15598270 408 qaddHYNRGNALARQGELEAAVDAYEQALERQPQLVAAQRNKALV 452
Cdd:COG3914 149 ----YLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNA 189
TPR super family cl33886
Tetratricopeptide (TPR) repeat [General function prediction only];
412-507 2.58e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


The actual alignment was detected with superfamily member COG0457:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 2.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270 412 HYNRGNALARQGELEAAVDAYEQALERQPQLVAAQRNKALVEELLRQRQEQAAQQQAGENKEQRQEASQQSPPSGSSQRP 491
Cdd:COG0457 113 LYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAA 192

                        90
                ....*....|....*.
gi 15598270 492 PRDAATVDAQKAQAAA 507
Cdd:COG0457 193 AEVLLALLLALEQALR 208
 
Name Accession Description Interval E-value
VWA_2 pfam13519
von Willebrand factor type A domain;
108-198 3.69e-10

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 57.30  E-value: 3.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270   108 MLAGDLSPTRLEQARRKLLDLLRTRNDAQTAIVVYAGSAHTLVPLSDDQLTARNLLDALKPSimpepGQRADL--AVRQA 185
Cdd:pfam13519  11 MRNGDYGPTRLEAAKDAVLALLKSLPGDRVGLVTFGDGPEVLIPLTKDRAKILRALRRLEPK-----GGGTNLaaALQLA 85

                          90
                  ....*....|...
gi 15598270   186 LDLLEQGAQGRGR 198
Cdd:pfam13519  86 RAALKHRRKNQPR 98
vWA_BatA_type cd01467
VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
 96-263 1.05e-07

VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.


Pssm-ID: 238744 [Multi-domain]  Cd Length: 180  Bit Score: 51.95  E-value: 1.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270  96 DPLVAiLQLTPGMLAGDLS-PTRLEQARRKLLDLLRTRNDAQTAIVVYAGSAHTLVPLSDDQLTARNLLDALKPSiMPEP 174
Cdd:cd01467   4 DIMIA-LDVSGSMLAQDFVkPSRLEAAKEVLSDFIDRRENDRIGLVVFAGAAFTQAPLTLDRESLKELLEDIKIG-LAGQ 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270 175 GQRADLAVRQALDLLEQgAQGRGRLL-----LLTSELSEPERQGIRSALEhRAARLAVLGVGT------PKGAPVQQEDG 243
Cdd:cd01467  82 GTAIGDAIGLAIKRLKN-SEAKERVIvlltdGENNAGEIDPATAAELAKN-KGVRIYTIGVGKsgsgpkPDGSTILDEDS 159

                       170       180
                ....*....|....*....|.
gi 15598270 244 S-FLKDDQGGILLPRLDESGL 263
Cdd:cd01467 160 LvEIADKTGGRIFRALDGFEL 180
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 254-452 1.29e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.53  E-value: 1.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270 254 LLPRLDESGLRRFAAEIGAGYQRLRPNDRDLDSLGLLARGGTLEEDRENALLRLQRWADQGYWLLLPLLLLAACAGRRGw 333
Cdd:COG3914   4 AALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLE- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270 334 LFCLPLLMLSLPQPAMAFQFEDLWLRPD------QQGQRLLQRGQADEAAKRFEdfrwKGLSLYQARDYAaaaqafaqgd 407
Cdd:COG3914  83 LAALLLQALGRYEEALALYRRALALNPDnaealfNLGNLLLALGRLEEALAALR----RALALNPDFAEA---------- 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 15598270 408 qaddHYNRGNALARQGELEAAVDAYEQALERQPQLVAAQRNKALV 452
Cdd:COG3914 149 ----YLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNA 189
TPR_1 pfam00515
Tetratricopeptide repeat;
412-441 1.75e-06

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 44.72  E-value: 1.75e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 15598270   412 HYNRGNALARQGELEAAVDAYEQALERQPQ 441
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPN 33
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 412-441 1.08e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 42.43  E-value: 1.08e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 15598270    412 HYNRGNALARQGELEAAVDAYEQALERQPQ 441
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPN 33
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
412-507 2.58e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 2.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270 412 HYNRGNALARQGELEAAVDAYEQALERQPQLVAAQRNKALVEELLRQRQEQAAQQQAGENKEQRQEASQQSPPSGSSQRP 491
Cdd:COG0457 113 LYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAA 192

                        90
                ....*....|....*.
gi 15598270 492 PRDAATVDAQKAQAAA 507
Cdd:COG0457 193 AEVLLALLLALEQALR 208
 
Name Accession Description Interval E-value
VWA_2 pfam13519
von Willebrand factor type A domain;
108-198 3.69e-10

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 57.30  E-value: 3.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270   108 MLAGDLSPTRLEQARRKLLDLLRTRNDAQTAIVVYAGSAHTLVPLSDDQLTARNLLDALKPSimpepGQRADL--AVRQA 185
Cdd:pfam13519  11 MRNGDYGPTRLEAAKDAVLALLKSLPGDRVGLVTFGDGPEVLIPLTKDRAKILRALRRLEPK-----GGGTNLaaALQLA 85

                          90
                  ....*....|...
gi 15598270   186 LDLLEQGAQGRGR 198
Cdd:pfam13519  86 RAALKHRRKNQPR 98
vWA_BatA_type cd01467
VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
 96-263 1.05e-07

VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.


Pssm-ID: 238744 [Multi-domain]  Cd Length: 180  Bit Score: 51.95  E-value: 1.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270  96 DPLVAiLQLTPGMLAGDLS-PTRLEQARRKLLDLLRTRNDAQTAIVVYAGSAHTLVPLSDDQLTARNLLDALKPSiMPEP 174
Cdd:cd01467   4 DIMIA-LDVSGSMLAQDFVkPSRLEAAKEVLSDFIDRRENDRIGLVVFAGAAFTQAPLTLDRESLKELLEDIKIG-LAGQ 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270 175 GQRADLAVRQALDLLEQgAQGRGRLL-----LLTSELSEPERQGIRSALEhRAARLAVLGVGT------PKGAPVQQEDG 243
Cdd:cd01467  82 GTAIGDAIGLAIKRLKN-SEAKERVIvlltdGENNAGEIDPATAAELAKN-KGVRIYTIGVGKsgsgpkPDGSTILDEDS 159

                       170       180
                ....*....|....*....|.
gi 15598270 244 S-FLKDDQGGILLPRLDESGL 263
Cdd:cd01467 160 LvEIADKTGGRIFRALDGFEL 180
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 254-452 1.29e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.53  E-value: 1.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270 254 LLPRLDESGLRRFAAEIGAGYQRLRPNDRDLDSLGLLARGGTLEEDRENALLRLQRWADQGYWLLLPLLLLAACAGRRGw 333
Cdd:COG3914   4 AALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLE- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270 334 LFCLPLLMLSLPQPAMAFQFEDLWLRPD------QQGQRLLQRGQADEAAKRFEdfrwKGLSLYQARDYAaaaqafaqgd 407
Cdd:COG3914  83 LAALLLQALGRYEEALALYRRALALNPDnaealfNLGNLLLALGRLEEALAALR----RALALNPDFAEA---------- 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 15598270 408 qaddHYNRGNALARQGELEAAVDAYEQALERQPQLVAAQRNKALV 452
Cdd:COG3914 149 ----YLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNA 189
TPR_1 pfam00515
Tetratricopeptide repeat;
412-441 1.75e-06

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 44.72  E-value: 1.75e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 15598270   412 HYNRGNALARQGELEAAVDAYEQALERQPQ 441
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPN 33
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 412-441 1.08e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 42.43  E-value: 1.08e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 15598270    412 HYNRGNALARQGELEAAVDAYEQALERQPQ 441
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPN 33
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 412-441 2.28e-04

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 38.66  E-value: 2.28e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 15598270   412 HYNRGNALARQGELEAAVDAYEQALERQPQ 441
Cdd:pfam07719   4 LYNLGLAYYKLGDYEEALEAYEKALELDPN 33
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
412-456 1.54e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 40.28  E-value: 1.54e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15598270 412 HYNRGNALARQGELEAAVDAYEQALERQPQLVAAQRNKALVEELL 456
Cdd:COG4785 110 YNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYL 154
TPR_11 pfam13414
TPR repeat;
416-452 2.04e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 36.30  E-value: 2.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 15598270   416 GNALARQGELEAAVDAYEQALERQPQLVAAQRNKALV 452
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLA 37
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
412-507 2.58e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 2.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598270 412 HYNRGNALARQGELEAAVDAYEQALERQPQLVAAQRNKALVEELLRQRQEQAAQQQAGENKEQRQEASQQSPPSGSSQRP 491
Cdd:COG0457 113 LYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAA 192

                        90
                ....*....|....*.
gi 15598270 492 PRDAATVDAQKAQAAA 507
Cdd:COG0457 193 AEVLLALLLALEQALR 208
TPR_8 pfam13181
Tetratricopeptide repeat;
412-441 4.18e-03

Tetratricopeptide repeat;


Pssm-ID: 404131 [Multi-domain]  Cd Length: 33  Bit Score: 35.07  E-value: 4.18e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 15598270   412 HYNRGNALARQGELEAAVDAYEQALERQPQ 441
Cdd:pfam13181   4 YYNLGLIYLKLGDYEEAKEYYEKALELDPD 33
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
412-452 5.54e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.83  E-value: 5.54e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15598270 412 HYNRGNALARQGELEAAVDAYEQALERQPQLVAAQRNKALV 452
Cdd:COG0457  45 LYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH