NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15598319|ref|NP_251813|]
View 

hypothetical protein PA3123 [Pseudomonas aeruginosa PAO1]

Protein Classification

RidA family protein( domain architecture ID 10000806)

RidA (reactive intermediate/imine deaminase A) family protein similar to Pseudomonas sp. 2-aminomuconate deaminase that hydrolyzes 2-aminomuconate to 4-oxalocrotonate, and releases ammonia in the modified meta-cleavage pathway by forming various compounds including acetaldehyde, pyruvic acid, acetyl-CoA, and succinate, that may enter the Krebs cycle

CATH:  3.30.1330.40
PubMed:  14624641|22094463|25975565
SCOP:  3001733

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 15-123 4.96e-39

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


:

Pssm-ID: 440021  Cd Length: 125  Bit Score: 127.22  E-value: 4.96e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319  15 PFSRAVRAGGFLFLSGQVPMSPSGEVVRGDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDMAHFAGFNEVYQRHV 94
Cdd:COG0251  16 PYSQAVRVGNLVFVSGQVPLDPDTGELGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTDMADFAAVNEVYAEYF 95

                        90       100       110
                ....*....|....*....|....*....|
gi 15598319  95 QGALPVRSTV-TAGLALGVDVEVEVQAWVG 123
Cdd:COG0251  96 GEGRPARTAVgVAALPKGALVEIEAIAALP 125
 
Name Accession Description Interval E-value
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 15-123 4.96e-39

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 127.22  E-value: 4.96e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319  15 PFSRAVRAGGFLFLSGQVPMSPSGEVVRGDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDMAHFAGFNEVYQRHV 94
Cdd:COG0251  16 PYSQAVRVGNLVFVSGQVPLDPDTGELGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTDMADFAAVNEVYAEYF 95

                        90       100       110
                ....*....|....*....|....*....|
gi 15598319  95 QGALPVRSTV-TAGLALGVDVEVEVQAWVG 123
Cdd:COG0251  96 GEGRPARTAVgVAALPKGALVEIEAIAALP 125
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 15-120 6.78e-37

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 121.63  E-value: 6.78e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319    15 PFSRAVRAGGFLFLSGQVPMSPS-GEVVRGDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDMAHFAGFNEVYQRH 93
Cdd:TIGR00004  15 PYSQAVKVGNTVYVSGQIPLDPStGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTDLNDFAEVNEVYGQY 94

                          90       100
                  ....*....|....*....|....*...
gi 15598319    94 VQGALPVRSTV-TAGLALGVDVEVEVQA 120
Cdd:TIGR00004  95 FDEHYPARSAVqVAALPKGVLVEIEAIA 122
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 16-120 1.45e-36

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 120.36  E-value: 1.45e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319  16 FSRAVRAGGFLFLSGQVPMSPSGEVVRGDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDMAHFAGFNEVYQRHVQ 95
Cdd:cd00448   1 YSQAVRVGNLVFVSGQIPLDPDGELVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFFG 80

                        90       100
                ....*....|....*....|....*..
gi 15598319  96 GA-LPVRSTV-TAGLALGVDVEVEVQA 120
Cdd:cd00448  81 EGpPPARTAVgVAALPPGALVEIEAIA 107
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 15-120 3.37e-31

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 107.00  E-value: 3.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319    15 PFSRAVRAGGFLFLSGQVPMSPS-GEVVRGDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDMAHFAGFNEVYQRH 93
Cdd:pfam01042   8 PYSQAVKAGNLVYVSGQIPLDPDtGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEVNEVYAEY 87

                          90       100
                  ....*....|....*....|....*....
gi 15598319    94 VQGA-LPVRSTV-TAGLALGVDVEVEVQA 120
Cdd:pfam01042  88 FDADkAPARSAVgVAALPLGALVEIEAIA 116
PRK11401 PRK11401
enamine/imine deaminase;
15-120 1.49e-13

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 62.39  E-value: 1.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319   15 PFSRAVRAGGFLFLSGQVPMSPSGEVVRGDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDMAHFAGFNEVYQRHV 94
Cdd:PRK11401  16 PYVQGVDLGSMVFTSGQIPVCPQTGEIPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITDLNDFATINEVYKQFF 95

                         90       100
                 ....*....|....*....|....*....
gi 15598319   95 ---QGALPVRSTVTAGlALGVDVEVEVQA 120
Cdd:PRK11401  96 dehQATYPTRSCVQVA-RLPKDVKLEIEA 123
 
Name Accession Description Interval E-value
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 15-123 4.96e-39

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 127.22  E-value: 4.96e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319  15 PFSRAVRAGGFLFLSGQVPMSPSGEVVRGDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDMAHFAGFNEVYQRHV 94
Cdd:COG0251  16 PYSQAVRVGNLVFVSGQVPLDPDTGELGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTDMADFAAVNEVYAEYF 95

                        90       100       110
                ....*....|....*....|....*....|
gi 15598319  95 QGALPVRSTV-TAGLALGVDVEVEVQAWVG 123
Cdd:COG0251  96 GEGRPARTAVgVAALPKGALVEIEAIAALP 125
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 15-120 6.78e-37

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 121.63  E-value: 6.78e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319    15 PFSRAVRAGGFLFLSGQVPMSPS-GEVVRGDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDMAHFAGFNEVYQRH 93
Cdd:TIGR00004  15 PYSQAVKVGNTVYVSGQIPLDPStGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTDLNDFAEVNEVYGQY 94

                          90       100
                  ....*....|....*....|....*...
gi 15598319    94 VQGALPVRSTV-TAGLALGVDVEVEVQA 120
Cdd:TIGR00004  95 FDEHYPARSAVqVAALPKGVLVEIEAIA 122
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 16-120 1.45e-36

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 120.36  E-value: 1.45e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319  16 FSRAVRAGGFLFLSGQVPMSPSGEVVRGDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDMAHFAGFNEVYQRHVQ 95
Cdd:cd00448   1 YSQAVRVGNLVFVSGQIPLDPDGELVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFFG 80

                        90       100
                ....*....|....*....|....*..
gi 15598319  96 GA-LPVRSTV-TAGLALGVDVEVEVQA 120
Cdd:cd00448  81 EGpPPARTAVgVAALPPGALVEIEAIA 107
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 15-120 3.37e-31

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 107.00  E-value: 3.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319    15 PFSRAVRAGGFLFLSGQVPMSPS-GEVVRGDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDMAHFAGFNEVYQRH 93
Cdd:pfam01042   8 PYSQAVKAGNLVYVSGQIPLDPDtGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEVNEVYAEY 87

                          90       100
                  ....*....|....*....|....*....
gi 15598319    94 VQGA-LPVRSTV-TAGLALGVDVEVEVQA 120
Cdd:pfam01042  88 FDADkAPARSAVgVAALPLGALVEIEAIA 116
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 16-120 6.32e-26

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 93.37  E-value: 6.32e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319  16 FSRAVRAGGFLFLSGQVPMSPSGevvrgDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDMAHFAGFNEVYQRHVQ 95
Cdd:cd06150   3 MSQAVVHNGTVYLAGQVADDTSA-----DITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADMADFAAMNAVWDAWVP 77

                        90       100
                ....*....|....*....|....*..
gi 15598319  96 -GALPVRSTVTAGLAL-GVDVEVEVQA 120
Cdd:cd06150  78 pGHAPARACVEAKLADpGYLVEIVVTA 104
YjgF_YER057c_UK114_like_6 cd06154
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 16-120 1.48e-17

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100011  Cd Length: 119  Bit Score: 72.20  E-value: 1.48e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319  16 FSRAVRAGGFLFLSGQVPMSPSGEVVRGDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDMAHFAGFNEVYQRHVQ 95
Cdd:cd06154  13 YSRAVRVGNWVFVSGTTGYDYDGMVMPGDAYEQTRQCLEIIEAALAEAGASLEDVVRTRMYVTDIADFEAVGRAHGEVFG 92

                        90       100
                ....*....|....*....|....*..
gi 15598319  96 GALPVRSTVTAGLALGVD--VEVEVQA 120
Cdd:cd06154  93 DIRPAATMVVVSLLVDPEmlVEIEVTA 119
YjgH_like cd02198
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, ...
 14-120 4.42e-16

YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100005  Cd Length: 111  Bit Score: 68.44  E-value: 4.42e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319  14 FPFSRAVRAGGFLFLSGQVPMSPSGEVVrGDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDM-AHFAGFNEVYQR 92
Cdd:cd02198   1 FGYSPAVRVGDTLFVSGQVGSDADGSVA-EDFEAQFRLAFQNLGAVLEAAGCSFDDVVELTTFHVDMaAHLPAFAAVKDE 79

                        90       100       110
                ....*....|....*....|....*....|
gi 15598319  93 HVQGALPVRSTV-TAGLAL-GVDVEVEVQA 120
Cdd:cd02198  80 YFKEPYPAWTAVgVAWLARpGLLVEIKVVA 109
PRK11401 PRK11401
enamine/imine deaminase;
15-120 1.49e-13

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 62.39  E-value: 1.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319   15 PFSRAVRAGGFLFLSGQVPMSPSGEVVRGDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDMAHFAGFNEVYQRHV 94
Cdd:PRK11401  16 PYVQGVDLGSMVFTSGQIPVCPQTGEIPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITDLNDFATINEVYKQFF 95

                         90       100
                 ....*....|....*....|....*....
gi 15598319   95 ---QGALPVRSTVTAGlALGVDVEVEVQA 120
Cdd:PRK11401  96 dehQATYPTRSCVQVA-RLPKDVKLEIEA 123
eu_AANH_C_1 cd06155
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 21-118 5.27e-13

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100012  Cd Length: 101  Bit Score: 60.35  E-value: 5.27e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319  21 RAGGFLFLSGQVPMSPSGevvrgDIQTQTEAVMARIGETLESCGARFDQLVKVTVWLSDMAHFAGFNEVYQRHVQGALP- 99
Cdd:cd06155   5 RTGGLLWISNVTASESDE-----TVEEQMESIFSKLREILQSNGLSLSDILYVTLYLRDMSDFAEVNSVYGTFFDKPNPp 79

                        90
                ....*....|....*....
gi 15598319 100 VRSTVTAGLALGVDVEVEV 118
Cdd:cd06155  80 SRVCVECGLPEGCDVQLSC 98
YjgF_YER057c_UK114_like_3 cd06151
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 26-120 2.01e-08

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100008  Cd Length: 126  Bit Score: 48.86  E-value: 2.01e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319  26 LFLSGQVP-----MSPSGEVVR-GDIQTQTEAVMARIGETLESCGARFDQLVKVTVWL------SDMAHFAGFNEVYQRH 93
Cdd:cd06151  14 IYLSGTVPavvnaSAPKGSPARyGDTETQTISVLKRIETILQSQGLTMGDVVKMRVFLvadpalDGKMDFAGFMKAYRQF 93

                        90       100       110
                ....*....|....*....|....*....|...
gi 15598319  94 ----VQGALPVRSTV-TAGLAL-GVDVEVEVQA 120
Cdd:cd06151  94 fgtaEQPNKPARSTLqVAGLVNpGWLVEIEVVA 126
YjgF_YER057c_UK114_like_4 cd06152
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 14-121 1.94e-05

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100009  Cd Length: 114  Bit Score: 40.75  E-value: 1.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319  14 FPFSRAVRAGGFLFLSGQVPMSPSGEVVRGDIQTQTEAVMARIGETLESCGAR-FDQLVKVTVWLSDMA---HFAGFNEV 89
Cdd:cd06152   1 LHYSQAVRIGDRIEISGQGGWDPDTGKIPEDLEEEIDQAFDNVELALKAAGGKgWEQVYKVNSYHVDIKneeAFGLMVEN 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 15598319  90 YQRHVQGALPVRSTV-TAGLAL-GVDVEVEVQAW 121
Cdd:cd06152  81 FKKWMPNHQPIWTCVgVTALGLpGMRVEIEVDAI 114
YjgF_YER057c_UK114_like_5 cd06153
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 16-100 6.32e-04

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100010  Cd Length: 114  Bit Score: 36.85  E-value: 6.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598319  16 FSRAVR----AGGFLFLSGQVPMSPSGEVVRGDIQTQTEAVMARIGETLESCGAR-----FDQLVKVTVWLSDMAHFAGF 86
Cdd:cd06153   1 FSRATLlaagGRTHLFISGTASIVGHGTVHPGDVEAQTRETLENIEALLEAAGRGggaqfLADLLRLKVYLRDREDLPAV 80

                        90
                ....*....|....
gi 15598319  87 NEVYQRHVQGALPV 100
Cdd:cd06153  81 RAILAARLGPAVPA 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH