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Conserved domains on  [gi|15598336|ref|NP_251830|]
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hypothetical protein PA3140 [Pseudomonas aeruginosa PAO1]

Protein Classification

ComEA family DNA-binding protein( domain architecture ID 11446237)

ComEA family DNA-binding protein contains a helix-hairpin-helix (HhH) motif, similar to Bacillus subtilis ComE operon protein 1, an integral membrane protein required for both DNA binding and transport

Gene Ontology:  GO:0003677
PubMed:  10908318|8692686
SCOP:  4001398

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 38-106 1.54e-25

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


:

Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 90.69  E-value: 1.54e-25
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598336  38 ATTVSPGEQVNINTVDEAALIRgLNGVGEAKARAILEYRAAHGPFVSVDQLLEVKGVGPALLEKNRARI 106
Cdd:COG1555   4 SASAAAGGKVDINTATAEELQT-LPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLKPYL 71
 
Name Accession Description Interval E-value
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 38-106 1.54e-25

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 90.69  E-value: 1.54e-25
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598336  38 ATTVSPGEQVNINTVDEAALIRgLNGVGEAKARAILEYRAAHGPFVSVDQLLEVKGVGPALLEKNRARI 106
Cdd:COG1555   4 SASAAAGGKVDINTATAEELQT-LPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLKPYL 71
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 44-106 2.74e-20

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 77.14  E-value: 2.74e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15598336    44 GEQVNINTVDEAALIRgLNGVGEAKARAILEYRAAHGPFVSVDQLLEVKGVGPALLEKNRARI 106
Cdd:pfam12836   1 AVGVDINTASAELLSR-VPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPKTFEQLAGFL 62
TIGR00426 TIGR00426
competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily ...
 44-108 1.89e-18

competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily recognized by this model include competence protein ComEA and closely related proteins from a number of species that exhibit competence for transformation by exongenous DNA, including Streptococcus pneumoniae, Bacillus subtilis, Neisseria meningitidis, and Haemophilus influenzae. This model represents a region of two tandem copies of a helix-hairpin-helix domain (pfam00633), each about 30 residues in length. Limited sequence similarity can be found among some members of this family N-terminal to the region covered by this model. [Cellular processes, DNA transformation]


Pssm-ID: 129520 [Multi-domain]  Cd Length: 69  Bit Score: 72.66  E-value: 1.89e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598336    44 GEQVNINTVDEAALIRGLNGVGEAKARAILEYRAAHGPFVSVDQLLEVKGVGPALLEKNRARIVI 108
Cdd:TIGR00426   5 GTRVNINTATAEELQRAMNGVGLKKAEAIVSYREEYGPFKTVEDLKQVPGIGNSLVEKNLAVITL 69
 
Name Accession Description Interval E-value
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 38-106 1.54e-25

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 90.69  E-value: 1.54e-25
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598336  38 ATTVSPGEQVNINTVDEAALIRgLNGVGEAKARAILEYRAAHGPFVSVDQLLEVKGVGPALLEKNRARI 106
Cdd:COG1555   4 SASAAAGGKVDINTATAEELQT-LPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLKPYL 71
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 44-106 2.74e-20

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 77.14  E-value: 2.74e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15598336    44 GEQVNINTVDEAALIRgLNGVGEAKARAILEYRAAHGPFVSVDQLLEVKGVGPALLEKNRARI 106
Cdd:pfam12836   1 AVGVDINTASAELLSR-VPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPKTFEQLAGFL 62
TIGR00426 TIGR00426
competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily ...
 44-108 1.89e-18

competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily recognized by this model include competence protein ComEA and closely related proteins from a number of species that exhibit competence for transformation by exongenous DNA, including Streptococcus pneumoniae, Bacillus subtilis, Neisseria meningitidis, and Haemophilus influenzae. This model represents a region of two tandem copies of a helix-hairpin-helix domain (pfam00633), each about 30 residues in length. Limited sequence similarity can be found among some members of this family N-terminal to the region covered by this model. [Cellular processes, DNA transformation]


Pssm-ID: 129520 [Multi-domain]  Cd Length: 69  Bit Score: 72.66  E-value: 1.89e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598336    44 GEQVNINTVDEAALIRGLNGVGEAKARAILEYRAAHGPFVSVDQLLEVKGVGPALLEKNRARIVI 108
Cdd:TIGR00426   5 GTRVNINTATAEELQRAMNGVGLKKAEAIVSYREEYGPFKTVEDLKQVPGIGNSLVEKNLAVITL 69
Tex COG2183
Transcriptional accessory protein Tex/SPT6 [Transcription];
47-96 3.29e-06

Transcriptional accessory protein Tex/SPT6 [Transcription];


Pssm-ID: 441786 [Multi-domain]  Cd Length: 719  Bit Score: 43.86  E-value: 3.29e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 15598336  47 VNINTVdEAALIRGLNGVGEAKARAILEYRAAHGPFVSVDQLLEVKGVGP 96
Cdd:COG2183 487 VDLNTA-SAPLLSYVSGLNPTLAKNIVAYRDENGAFKSRKELLKVPRLGP 535
DnaE COG0587
DNA polymerase III, alpha subunit [Replication, recombination and repair];
50-90 1.17e-03

DNA polymerase III, alpha subunit [Replication, recombination and repair];


Pssm-ID: 440352 [Multi-domain]  Cd Length: 1050  Bit Score: 36.59  E-value: 1.17e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 15598336   50 NTVDEAALIR-GLN---GVGEAKARAILEYRAAHGPFVSVDQLLE 90
Cdd:COG0587  805 FTVEPGGAIRlGLGaikGVGEAAAEAIVAAREENGPFTSLFDFCR 849
PulK COG3156
Type II secretory pathway, component PulK [Intracellular trafficking, secretion, and vesicular ...
 75-101 2.39e-03

Type II secretory pathway, component PulK [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442390 [Multi-domain]  Cd Length: 307  Bit Score: 35.75  E-value: 2.39e-03
                        10        20
                ....*....|....*....|....*..
gi 15598336  75 YRAAHGPFVSVDQLLEVKGVGPALLEK 101
Cdd:COG3156 173 YRPANGPFASVSELRLVKGMTPELYAR 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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