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Conserved domains on  [gi|15598380|ref|NP_251874|]
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HTH-type transcriptional regulator [Pseudomonas aeruginosa PAO1]

Protein Classification

MurR/RpiR family transcriptional regulator( domain architecture ID 11485311)

MurR/RpiR family transcriptional regulator similar to Escherichia coli MurR, which represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid

Gene Ontology:  GO:0006355|GO:0006351|GO:0003677|GO:0003700|GO:0097367

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 3-285 0e+00

DNA-binding transcriptional regulator HexR; Provisional


:

Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 522.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380    3 NLLEQIQSRLDELNKAERKVAEVILQNPQQATRFSIAALAQAAAVSEPTVNRFCRSFGMSGYPELKIQLAQSLASGAAFV 82
Cdd:PRK11302   2 NMLEKIQSRLEHLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAQSLANGTPYV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380   83 TQAVAEDDGPEAYTRKIFSNTIASLDSAHKLLDPRVIDRAVDLLIQARQIHFFGLGASASVALDAQHKFFRFNLAVSAQA 162
Cdd:PRK11302  82 NRNVEEDDSVEAYTGKIFESAMASLDHARQSLDPSAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKFFRFNVPVVYFD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380  163 DVLMQRMIASVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGLTAAGSPLARASTLCLDIPLPEDTDIYMPMTSRI 242
Cdd:PRK11302 162 DIVMQRMSCMNSSDGDVVVLISHTGRTKSLVELAQLARENGATVIAITSAGSPLAREATLALTLDVPEDTDIYMPMVSRI 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 15598380  243 VQLTVLDVLATGVTLRRGVDFQPHLRRIKESLVPTRYPLDEDN 285
Cdd:PRK11302 242 AQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDLLN 284
 
Name Accession Description Interval E-value
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 3-285 0e+00

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 522.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380    3 NLLEQIQSRLDELNKAERKVAEVILQNPQQATRFSIAALAQAAAVSEPTVNRFCRSFGMSGYPELKIQLAQSLASGAAFV 82
Cdd:PRK11302   2 NMLEKIQSRLEHLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAQSLANGTPYV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380   83 TQAVAEDDGPEAYTRKIFSNTIASLDSAHKLLDPRVIDRAVDLLIQARQIHFFGLGASASVALDAQHKFFRFNLAVSAQA 162
Cdd:PRK11302  82 NRNVEEDDSVEAYTGKIFESAMASLDHARQSLDPSAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKFFRFNVPVVYFD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380  163 DVLMQRMIASVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGLTAAGSPLARASTLCLDIPLPEDTDIYMPMTSRI 242
Cdd:PRK11302 162 DIVMQRMSCMNSSDGDVVVLISHTGRTKSLVELAQLARENGATVIAITSAGSPLAREATLALTLDVPEDTDIYMPMVSRI 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 15598380  243 VQLTVLDVLATGVTLRRGVDFQPHLRRIKESLVPTRYPLDEDN 285
Cdd:PRK11302 242 AQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDLLN 284
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-274 3.58e-87

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 261.79  E-value: 3.58e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380   1 MKNLLEQIQSRLDELNKAERKVAEVILQNPQQATRFSIAALAQAAAVSEPTVNRFCRSFGMSGYPELKIQLAQSLASGAA 80
Cdd:COG1737   4 AMSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380  81 FVT--QAVAEDDGPEAYTRKIFSNTIASLDSAHKLLDPRVIDRAVDLLIQARQIHFFGLGASASVALDAQHKFFRFNLAV 158
Cdd:COG1737  84 SYErlRRLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNV 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380 159 SA-QADVLMQRMIASVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGLTA-AGSPLARASTLCLDIPLPEDTDIYM 236
Cdd:COG1737 164 VLlDGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDsPLSPLAKLADVVLYVPSEEPTLRSS 243

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 15598380 237 PMTSRIVQLTVLDVLATGVTLRRGVDFQPHLRRIKESL 274
Cdd:COG1737 244 AFSSRVAQLALIDALAAAVAQRDGDKARERLERTEALL 281
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 119-254 2.17e-43

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 144.68  E-value: 2.17e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380 119 IDRAVDLLIQARQIHFFGLGASASVALDAQHKFFRFNLAVSAQADVLMQRMIASVAHTGDLFVVISYTGRTRELVEVAHL 198
Cdd:cd05013   3 LEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAAEI 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15598380 199 ARENGASVLGLTAAG-SPLARASTLCLDIPLPEDTDIYMPMTSRIVQLTVLDVLATG 254
Cdd:cd05013  83 AKERGAKVIAITDSAnSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALFLA 139
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
 2-78 1.83e-28

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 103.95  E-value: 1.83e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598380     2 KNLLEQIQSRLDELNKAERKVAEVILQNPQQATRFSIAALAQAAAVSEPTVNRFCRSFGMSGYPELKIQLAQSLASG 78
Cdd:pfam01418   1 MGLLEKIQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALAGELANS 77
 
Name Accession Description Interval E-value
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 3-285 0e+00

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 522.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380    3 NLLEQIQSRLDELNKAERKVAEVILQNPQQATRFSIAALAQAAAVSEPTVNRFCRSFGMSGYPELKIQLAQSLASGAAFV 82
Cdd:PRK11302   2 NMLEKIQSRLEHLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAQSLANGTPYV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380   83 TQAVAEDDGPEAYTRKIFSNTIASLDSAHKLLDPRVIDRAVDLLIQARQIHFFGLGASASVALDAQHKFFRFNLAVSAQA 162
Cdd:PRK11302  82 NRNVEEDDSVEAYTGKIFESAMASLDHARQSLDPSAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKFFRFNVPVVYFD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380  163 DVLMQRMIASVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGLTAAGSPLARASTLCLDIPLPEDTDIYMPMTSRI 242
Cdd:PRK11302 162 DIVMQRMSCMNSSDGDVVVLISHTGRTKSLVELAQLARENGATVIAITSAGSPLAREATLALTLDVPEDTDIYMPMVSRI 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 15598380  243 VQLTVLDVLATGVTLRRGVDFQPHLRRIKESLVPTRYPLDEDN 285
Cdd:PRK11302 242 AQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDLLN 284
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-274 3.58e-87

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 261.79  E-value: 3.58e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380   1 MKNLLEQIQSRLDELNKAERKVAEVILQNPQQATRFSIAALAQAAAVSEPTVNRFCRSFGMSGYPELKIQLAQSLASGAA 80
Cdd:COG1737   4 AMSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380  81 FVT--QAVAEDDGPEAYTRKIFSNTIASLDSAHKLLDPRVIDRAVDLLIQARQIHFFGLGASASVALDAQHKFFRFNLAV 158
Cdd:COG1737  84 SYErlRRLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNV 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380 159 SA-QADVLMQRMIASVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGLTA-AGSPLARASTLCLDIPLPEDTDIYM 236
Cdd:COG1737 164 VLlDGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDsPLSPLAKLADVVLYVPSEEPTLRSS 243

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 15598380 237 PMTSRIVQLTVLDVLATGVTLRRGVDFQPHLRRIKESL 274
Cdd:COG1737 244 AFSSRVAQLALIDALAAAVAQRDGDKARERLERTEALL 281
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
4-261 1.08e-56

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 192.44  E-value: 1.08e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380    4 LLEQIQSRLDELNKAERKVAEVILQNPQQATRFSIAALAQAAAVSEPTVNRFCRSFGMSGYPELKIQLAQSLASGAAFVT 83
Cdd:PRK14101 343 VFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPMSH 422

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380   84 QAVAEDDGPEAYTRKIFSNTIASLDSAHKLLDPRVIDRAVDLLIQARQIHFFGLGASASVALDAQHKFFRFNLAVSAQAD 163
Cdd:PRK14101 423 SQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIPTIAYGD 502

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380  164 VLMQRMIASVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGLTAAGSPLARASTLCLDIPLPEDTDIYMPMTSRIV 243
Cdd:PRK14101 503 LYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLAKRATVALETDHIEMRESQLSMISRIL 582

                        250
                 ....*....|....*...
gi 15598380  244 QLTVLDVLATGVTLRRGV 261
Cdd:PRK14101 583 HLVMIDILAVGVAIRRAA 600
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
7-251 2.21e-45

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 154.92  E-value: 2.21e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380    7 QIQSRLDELNKAERKVAEVILQNPQQATRFSIAALAQAAAVSEPTVNRFCRSFGMSGYPELKIQLAQSLASGAAFVTQAV 86
Cdd:PRK11337  18 YIRMKQEGLTPLESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRSALEDYFSQSEQVLHSEL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380   87 AEDDGPEAYTRKIFSNTIASLDSAHKLLDPRVIDRAVDLLIQARQIHFFGLGASASVALDAQHKFFRFNLAVSAQADVLM 166
Cdd:PRK11337  98 SFDDAPQDVVNKVFNTSLQAIEETQSILDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQHKFLRIGVRCQAYDDAHI 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380  167 QRMIASVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGLT-AAGSPLARASTLCLDIPLPEDTDIYMPMTSRIVQL 245
Cdd:PRK11337 178 MLMSAALLQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITnSYHSPIAKLADYVICSTAQGSPLLGENAAARIAQL 257


                 ....*.
gi 15598380  246 TVLDVL 251
Cdd:PRK11337 258 NILDAF 263
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 119-254 2.17e-43

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 144.68  E-value: 2.17e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380 119 IDRAVDLLIQARQIHFFGLGASASVALDAQHKFFRFNLAVSAQADVLMQRMIASVAHTGDLFVVISYTGRTRELVEVAHL 198
Cdd:cd05013   3 LEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAAEI 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15598380 199 ARENGASVLGLTAAG-SPLARASTLCLDIPLPEDTDIYMPMTSRIVQLTVLDVLATG 254
Cdd:cd05013  83 AKERGAKVIAITDSAnSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALFLA 139
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
5-273 9.09e-30

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 113.64  E-value: 9.09e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380    5 LEQIQSRLDELNKAERKVAEVILQNPQQATRFSIAALAQAAAVSEPTVNRFCRSFGMSGYPELKIQLAQSLASG------ 78
Cdd:PRK15482   4 LTKIRNAESEFTENEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASrektna 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380   79 -AAFVTQAVAEDDGPEAYTRKIFSNTIASLDSAHKLLDPRVIDRAVDLLIQARQIHFFGLGASASVALDAQHKFFRFNLA 157
Cdd:PRK15482  84 tALHLHSSITSDDSLEVIARKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYR 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380  158 VSAQADVLMQRMIASVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGLTA-AGSPLARASTLCLDIPLPEDTDIYM 236
Cdd:PRK15482 164 VACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSlADSPLRRLAHFTLDTVSGETEWRSS 243

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 15598380  237 PMTSRIVQLTVLDVLATGVTLRRGVDfqpHLRRIKES 273
Cdd:PRK15482 244 SMSTRTAQNSVTDLLFVGLVQLNDVE---SLKMIQRS 277
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
 2-78 1.83e-28

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 103.95  E-value: 1.83e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598380     2 KNLLEQIQSRLDELNKAERKVAEVILQNPQQATRFSIAALAQAAAVSEPTVNRFCRSFGMSGYPELKIQLAQSLASG 78
Cdd:pfam01418   1 MGLLEKIQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALAGELANS 77
PRK11557 PRK11557
MurR/RpiR family transcriptional regulator;
7-251 3.37e-24

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183195 [Multi-domain]  Cd Length: 278  Bit Score: 98.68  E-value: 3.37e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380    7 QIQSRLDELNKAERKVAEVILQNPQQATRFSIAALAQAAAVSEPTVNRFCRSFGMSGYPELKIQLAQSLAS----GAAFV 82
Cdd:PRK11557   2 RIRQRYPGLAQSDRKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLALSEALASqpepPSVPV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380   83 TQAVAEDDGPEAYTRKIFSNTIASLDSAHKLLDPRVIDRAVDLLIQARQIHFFGLGASASVALDAQHKFFRFNLAVSAQA 162
Cdd:PRK11557  82 HNQIRGDDPLRLVGEKLIKENTAAMRATLDVNSEEKLHECVTMLRSARRIILTGIGASGLVAQNFAWKLMKIGINAVAER 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380  163 DvlMQRMIASVA--HTGDLFVVISYTGRTRELVEVAHLARENGASVLGLTA-AGSPLARASTLCLDIPLPEDTDIYMPMT 239
Cdd:PRK11557 162 D--MHALLATVQalSPDDLLLAISYSGERRELNLAADEALRVGAKVLAITGfTPNALQQRASHCLYTIAEEQATRSAAIS 239

                        250
                 ....*....|..
gi 15598380  240 SRIVQLTVLDVL 251
Cdd:PRK11557 240 STHAQGMLTDLL 251
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 125-253 4.60e-22

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 88.90  E-value: 4.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380   125 LLIQARQIHFFGLGASASVALDAQHKF--FRFNLAVSAQADVLMQRMIASVAHtGDLFVVISYTGRTRELVEVAHLAREN 202
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFeeIGYKVVEVELASELRHGVLALVDE-DDLVIAISYSGETKDLLAAAELAKAR 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15598380   203 GASVLGLTA-AGSPLARASTLCLDIPLPEDTdIYMPMTSRIVQLTVLDVLAT 253
Cdd:pfam01380  80 GAKIIAITDsPGSPLAREADHVLYINAGPET-GVASTKSITAQLAALDALAV 130
SIS_Kpsf cd05014
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ...
 177-252 2.99e-13

KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.


Pssm-ID: 240145 [Multi-domain]  Cd Length: 128  Bit Score: 65.26  E-value: 2.99e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598380 177 GDLFVVISYTGRTRELVEVAHLARENGASVLGLTA-AGSPLARASTLCLDIPLPEDTDIY--MPMTSRIVQLTVLDVLA 252
Cdd:cd05014  48 GDVVIAISNSGETDELLNLLPHLKRRGAPIIAITGnPNSTLAKLSDVVLDLPVEEEACPLglAPTTSTTAMLALGDALA 126
SIS_GmhA cd05006
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ...
 114-251 1.02e-11

Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).


Pssm-ID: 240139 [Multi-domain]  Cd Length: 177  Bit Score: 62.14  E-value: 1.02e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380 114 LDPRVIDRAVDLLIQARQ----IHFFGLGASASvalDAQH---------KFFRFNLAV----------SAQA-----DVL 165
Cdd:cd05006  14 LLAEAIEQAAQLLAEALLnggkILICGNGGSAA---DAQHfaaelvkrfEKERPGLPAialttdtsilTAIAndygyEEV 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380 166 MQRMIASVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGLTAA-GSPLARASTLCLDIPLPEdtdiympmTSRI-- 242
Cdd:cd05006  91 FSRQVEALGQPGDVLIGISTSGNSPNVLKALEAAKERGMKTIALTGRdGGKLLELADIEIHVPSDD--------TPRIqe 162


                ....*....
gi 15598380 243 VQLTVLDVL 251
Cdd:cd05006 163 VHLLIGHIL 171
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
 169-260 2.12e-11

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 63.07  E-value: 2.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380 169 MIASvahtGDLFVVISYTGRTRELVEVAHLARENGASVLGLTA-AGSPLARASTLCLDIPLPEDTDIY--MPMTSRIVQL 245
Cdd:COG0794  88 MITP----GDVVIAISNSGETEELLALLPLLKRLGVPLIAITGnPDSTLARAADVVLDLPVEREACPLnlAPTTSTTATL 163

                        90
                ....*....|....*
gi 15598380 246 TVLDVLATGVTLRRG 260
Cdd:COG0794 164 ALGDALAVALLEARG 178
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 95-233 4.29e-11

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 60.28  E-value: 4.29e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380  95 YTRKIFSNTIASLDSahklLDPRVIDRAVDLLIQARQIHFFGLGASASVAldaqhKFFrfnlavsaqADVLMQ------- 167
Cdd:cd05005   3 YLSLILEEIENVADK----IDEEELDKLISAILNAKRIFVYGAGRSGLVA-----KAF---------AMRLMHlglnvyv 64

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598380 168 --RMIASVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGLTA-AGSPLARASTLCLDIPLPEDTD 233
Cdd:cd05005  65 vgETTTPAIGPGDLLIAISGSGETSSVVNAAEKAKKAGAKVVLITSnPDSPLAKLADVVVVIPAATKDD 133
SIS_GlmS_GlmD_1 cd05008
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ...
 132-230 1.79e-08

SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.


Pssm-ID: 240141 [Multi-domain]  Cd Length: 126  Bit Score: 51.73  E-value: 1.79e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380 132 IHFFGLGASASVALDAQHkffrfnlAVSAQADVLMQRMIAS-------VAHTGDLFVVISYTGRTRELVEVAHLARENGA 204
Cdd:cd05008   2 ILIVGCGTSYHAALVAKY-------LLERLAGIPVEVEAASefryrrpLLDEDTLVIAISQSGETADTLAALRLAKEKGA 74

                        90       100
                ....*....|....*....|....*...
gi 15598380 205 SVLGLT-AAGSPLARASTLCLDIPL-PE 230
Cdd:cd05008  75 KTVAITnVVGSTLAREADYVLYLRAgPE 102
AgaS COG2222
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ...
 177-240 4.99e-07

Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441824 [Multi-domain]  Cd Length: 336  Bit Score: 50.28  E-value: 4.99e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598380 177 GDLFVVISYTGRTRELVEVAHLARENGASVLGLT-AAGSPLARASTLCldIPLPEDTDIYMPMTS 240
Cdd:COG2222  83 GTLVVAISRSGNSPEVVAALELAKARGARTLAITnNPDSPLAEAADRV--LPLPAGPEKSVAATK 145
SIS_PGI_PMI_1 cd05017
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the ...
 131-213 3.26e-05

The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the first SIS domain.


Pssm-ID: 240148 [Multi-domain]  Cd Length: 119  Bit Score: 42.25  E-value: 3.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380 131 QIHFFGLGASASVALDAQHKFF-RFNLAVSAQADVLMQRMIASvahtGDLFVVISYTGRTRELVEVAHLARENGASVLGL 209
Cdd:cd05017   1 NIVILGMGGSGIGGDLLESLLLdEAKIPVYVVKDYTLPAFVDR----KTLVIAVSYSGNTEETLSAVEQAKERGAKIVAI 76


                ....
gi 15598380 210 TAAG 213
Cdd:cd05017  77 TSGG 80
SIS_1 cd05710
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ...
 179-236 4.08e-05

A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240214 [Multi-domain]  Cd Length: 120  Bit Score: 42.18  E-value: 4.08e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598380 179 LFVVISYTGRTRELVEVAHLARENGASVLGLT-AAGSPLARASTLCL------DIPLPEDTDIYM 236
Cdd:cd05710  50 VVILASHSGNTKETVAAAKFAKEKGATVIGLTdDEDSPLAKLADYVIvygfeiDAVEEKYLLLYM 114
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 119-210 1.39e-04

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 41.04  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380   119 IDRAVDLLIQA----RQIHFFGLGASAsvaLDAQHKFFRFN------------LAVSAQADVLMQRMIA----------- 171
Cdd:pfam13580  21 IEKAADLIAASlangGKVYAFGTGHSA---APAEELFARAGglagfepillpaLALHTDASATISTALErdegyarqila 97

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 15598380   172 -SVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGLT 210
Cdd:pfam13580  98 lYPGRPGDVLIVISNSGINAVPVEAALEAKERGMKVIALT 137
PRK13937 PRK13937
phosphoheptose isomerase; Provisional
 100-227 1.75e-04

phosphoheptose isomerase; Provisional


Pssm-ID: 184408 [Multi-domain]  Cd Length: 188  Bit Score: 41.38  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380  100 FSNTIASLDSAHKLLDPRVIDrAVDLLIQA----RQIHFFGLGASASvalDAQHkfF------RFNL---AVSAQA---- 162
Cdd:PRK13937   6 FRESQAVMEAFLESLLEAIAK-VAEALIEAlangGKILLCGNGGSAA---DAQH--IaaelvgRFKKerpALPAIAlttd 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598380  163 -------------DVLMQRMIASVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGLT-AAGSPLARASTLCLDIP 227
Cdd:PRK13937  80 tsaltaigndygfERVFSRQVEALGRPGDVLIGISTSGNSPNVLAALEKARELGMKTIGLTgRDGGKMKELCDHLLIVP 158
gutQ PRK11543
arabinose-5-phosphate isomerase GutQ;
178-260 1.80e-04

arabinose-5-phosphate isomerase GutQ;


Pssm-ID: 183186 [Multi-domain]  Cd Length: 321  Bit Score: 42.45  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380  178 DLFVVISYTGRTRELVEVAHLARENGASVLGLTA-AGSPLARASTLCLDIPLP-EDTDIYMPMTSRIVQ-LTVLDVLATG 254
Cdd:PRK11543  91 DVMLFISYSGGAKELDLIIPRLEDKSIALLAMTGkPTSPLGLAAKAVLDISVErEACPMHLAPTSSTVNtLMMGDALAMA 170


                 ....*.
gi 15598380  255 VTLRRG 260
Cdd:PRK11543 171 VMQARG 176
SIS cd04795
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 132-212 3.30e-04

SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240112 [Multi-domain]  Cd Length: 87  Bit Score: 38.89  E-value: 3.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380 132 IHFFGLGASASVALDAQHKFFRFN--LAVSAQADVLMQRMIASVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGL 209
Cdd:cd04795   1 IFVIGIGGSGAIAAYFALELLELTgiEVVALIATELEHASLLSLLRKGDVVIALSYSGRTEELLAALEIAKELGIPVIAI 80


                ...
gi 15598380 210 TAA 212
Cdd:cd04795  81 TDA 83
PRK08674 PRK08674
bifunctional phosphoglucose/phosphomannose isomerase; Validated
 130-213 3.49e-04

bifunctional phosphoglucose/phosphomannose isomerase; Validated


Pssm-ID: 181536 [Multi-domain]  Cd Length: 337  Bit Score: 41.51  E-value: 3.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380  130 RQIHFFGLGASASVAldaqhKFFRFNLAVSAQADVLMQR--MIASVAHTGDLFVVISYTGRTRELVEVAHLARENGASVL 207
Cdd:PRK08674  35 DNIVISGMGGSGIGG-----DLLRILLFDELKVPVFVNRdyTLPAFVDEKTLVIAVSYSGNTEETLSAVEQALKRGAKII 109


                 ....*.
gi 15598380  208 GLTAAG 213
Cdd:PRK08674 110 AITSGG 115
PRK02947 PRK02947
sugar isomerase domain-containing protein;
119-210 1.28e-03

sugar isomerase domain-containing protein;


Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 39.47  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598380  119 IDRAVDLLIQARQ----IHFFGLGASASVALDAqhkFFR-----------------FNLAVSAQ--------ADVLMQRm 169
Cdd:PRK02947  26 IEKAADLIADSIRngglIYVFGTGHSHILAEEV---FYRagglapvnpilepslmlHEGAVASSylervegyAKAILDR- 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 15598380  170 iaSVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGLT 210
Cdd:PRK02947 102 --YDIRPGDVLIVVSNSGRNPVPIEMALEAKERGAKVIAVT 140
PRK13938 PRK13938
phosphoheptose isomerase; Provisional
 163-227 9.09e-03

phosphoheptose isomerase; Provisional


Pssm-ID: 139997 [Multi-domain]  Cd Length: 196  Bit Score: 36.64  E-value: 9.09e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15598380  163 DVLMQRMIASVAHTGDLFVVISYTGRTRELVEVAHLARENGASVLGLTA-AGSPLARASTLCLDIP 227
Cdd:PRK13938 100 DTVFARALEGSARPGDTLFAISTSGNSMSVLRAAKTARELGVTVVAMTGeSGGQLAEFADFLINVP 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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