|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
6-382 |
6.36e-119 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 349.95 E-value: 6.36e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 6 LLILGALSAFGPLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAA 85
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 86 CALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLT 165
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 166 LFAALAGLGVALWLPETIPADGERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYG 245
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 246 WLFGSNAAGFIVMAQVNARLLRYRGPAFWLRRIIWGYLACGLALLGIASLQPATLWPLLVPLFGCVASLGCIIPNASACA 325
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 15598769 326 MAGQGQHAGSASALMGSLQFSVAAGASALVGVLHDGTAIPMTLVIAVCGAVATLLAW 382
Cdd:cd17320 321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLI 377
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
17-386 |
4.44e-86 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 266.01 E-value: 4.44e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 17 PLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLI 96
Cdd:PRK11102 4 PLAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 97 AARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVA 176
Cdd:PRK11102 84 YMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 177 LWLPETIPADGERP-PLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYGWLFGSNAAGF 255
Cdd:PRK11102 164 FFIPETLPKERRQPfHLRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNIVFL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 256 IVMAQVNARLLRYRGPAFWLRRIIWGYLACGLALLGIASLQPAtLWPLLVPL---FGCVASLGciiPNASACAMAGQGQH 332
Cdd:PRK11102 244 FVMTIINSRFVRRVGALNMLRFGLWIQFIMGIWLVVSALLDLG-FWALVVGVaafVGCVSMIS---SNAMAVILDEFPHM 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15598769 333 AGSASALMGSLQFSVAAGASALVGVLHDGTAIPMTLVIAVCGAVATLLAWQTGR 386
Cdd:PRK11102 320 AGTASSLAGTLRFGIGAIVGALLSLAPFTSAWPMVWSMAFCSILSILFYLYASR 373
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
3-380 |
1.78e-75 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 239.21 E-value: 1.78e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 3 LRILLILGALSAFGPLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLA 82
Cdd:TIGR00710 4 KAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 83 SAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFV 162
Cdd:TIGR00710 84 SLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 163 CLTLFAALAGLGVALWLPETIPADgERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAE 242
Cdd:TIGR00710 164 FLSLAGILLSALIFFILPETLPYE-ARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 243 HYGWLFGSNAAGFIVMAQVNARLLRYRGpAFWLRRIIWGYLACGLALLGIASLQPATLWPLLVPLFGCVA-SLGCIIPNA 321
Cdd:TIGR00710 243 VFGLLFALNIIAMIFGGFLNGRFIKKWG-AKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGiGNSMISSIA 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15598769 322 SACAMAGQGQHAGSASALMGSLQFSVAAGASALVGVLHDGTAIPMTLVIAVCGAVATLL 380
Cdd:TIGR00710 322 MAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVSVLA 380
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
9-379 |
2.13e-57 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 192.41 E-value: 2.13e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 9 LGALSAFGPLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACAL 88
Cdd:PRK11043 11 LAGLSMLGFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLW 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 89 APSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFA 168
Cdd:PRK11043 91 VESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAIT 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 169 ALAGLGVALWLPETIPADGERPPLSgalgqYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLyGIPAEHYGWLF 248
Cdd:PRK11043 171 LLLILPTLRLKPSKKARKQSQDALT-----FKQLLKSKTYLGNVLIFAACSAAFFAWLTGSPFILEQM-GYSPADIGLSY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 249 GSNAAGFIVMAQVNARLLRYRGPAFWLRRIIWGYLACGLALLGIASLQPATLWPLLVPLFGCVASLGCIIPNASACAMAG 328
Cdd:PRK11043 245 VPQTIAFLVGGYGCRAALQKWGGEQLLPWLLVLFAVSVIAIWLASLLSHPSLVPLLIPFCVMAAANGAIYPIVVAQALRP 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 15598769 329 QGQHAGSASALMGSLQFSVAAGASALVGVLHDGTAIPMTLVIAVCGAVATL 379
Cdd:PRK11043 325 FPQATGKAAALQNTLQLGLCFLASLLVSALISTPLLTTGSVMLSTVVLVAL 375
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
2-354 |
5.78e-43 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 154.29 E-value: 5.78e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 2 NLRILLILGALSAFGPLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTL 81
Cdd:PRK11652 6 NVNLLFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFIL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 82 ASAACALAPSLEWLIAARFVQALG-GCAGmVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSI 160
Cdd:PRK11652 86 GTLVALFAHSLTVLIAASAIQGLGtGVGG-VMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRAC 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 161 FVCLTLFAALAGLGVALWLPETIPADGERPPLsgaLGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIP 240
Cdd:PRK11652 165 YLFLLLLGAGVTFSMARWMPETRPADARRTRV---LASYRTLLSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAVLGLS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 241 AEHYGWLFGSNAAGFIVMAQVNARLLRYRGPAFWlrriiWGYLACGLAllGIASLQPA-----TLWPLLVPLFGCVASLG 315
Cdd:PRK11652 242 SMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMW-----QSVICCLLA--GLLMWIPGwfgvmNVWTLLVPAALFFFGAG 314
|
330 340 350
....*....|....*....|....*....|....*....
gi 15598769 316 CIIPNASACAMAGQGQHAGSASALMGSLQfSVAAGASAL 354
Cdd:PRK11652 315 MLFPLATSGAMEPFPYLAGTAGALLGGLQ-NIGSGLAAL 352
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-345 |
2.62e-41 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 148.58 E-value: 2.62e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 4 RILLILGALSAFGPLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLAS 83
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 84 AACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVC 163
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 164 LTLFAALAGLGVALWLPETIPADGERPPlsgalGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEH 243
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLR-----GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 244 YGWLFGSNAAGFIVMAQVNARLLRYRGPAfwlRRIIWGYLACGLALLGIASLQpaTLWPLLVPLFGCVASLGCIIPNASA 323
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADRFGRR---RLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGLLFPLLQA 319
|
330 340
....*....|....*....|...
gi 15598769 324 CAMAGQG-QHAGSASALMGSLQF 345
Cdd:COG2814 320 LVAELAPpEARGRASGLYNSAFF 342
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
6-382 |
3.48e-35 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 133.08 E-value: 3.48e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 6 LLILGALSAFGPLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAA 85
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 86 CALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWqGWQSIFVCLT 165
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 166 LFAALAGLGVALWLPEtiPADGERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYG 245
Cdd:cd17474 160 ALIPVAFLAILFLLPE--PKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 246 WLFGSNAAGFIVMAQVNARLLRYRGPAFWLrrIIWGYLACGLALLGIASLQpaTLWPLLVPLFGCVASLGCIIPNASACA 325
Cdd:cd17474 238 LLFAGWSVLLALGSLFVGRLLKKRFGARRI--LVIGLLLYALSLLLLGFVP--SLALLLIAIVLFGLGLGLNLPLLTTLV 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15598769 326 MAGQGQHA-GSASALMGSLQFSVAAGASALVGVLHDGTAIPMTLVIAVCGAVATLLAW 382
Cdd:cd17474 314 TELAPEEErGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
18-382 |
1.15e-30 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 121.20 E-value: 1.15e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 18 LAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIA 97
Cdd:PRK15402 27 IANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 98 ARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVAL 177
Cdd:PRK15402 107 LRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWR 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 178 WLPETIPADGERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYGWL----FGSNAA 253
Cdd:PRK15402 187 AMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPVILISGEQLSSYEYGLLqvpvFGALIA 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 254 GFIVMAQVNARLLryrgpafwLRRII----WGYLAcGLALLGIASLQPATLWPLLVPLFGCVAsLGCIIPNASACAMA-- 327
Cdd:PRK15402 267 GNLTLARLTSRRP--------LRSLIrmglWPMVA-GLLLAALATVISSHAYLWLTAGLSLYA-FGIGLANAGLYRLTlf 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 15598769 328 GQGQHAGSASALMGSLQFSVAAGASALVGVLHDGTAIPM-TLVIAVCGAVATLLAW 382
Cdd:PRK15402 337 SSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLfNLFNLANGLLWLLLVR 392
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
26-358 |
2.18e-27 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 111.51 E-value: 2.18e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 26 SFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALG 105
Cdd:cd17503 18 ALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 106 GCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALwlpetIPA 185
Cdd:cd17503 98 GGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPL-----LDL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 186 dgerpplsgalgqyrRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYGWLFGSNAAGFIVMAQVNARL 265
Cdd:cd17503 173 ---------------RLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 266 LRYRGPAfwlRRIIWGYLACGLALLGIASLQPAT-LWPLLVPLFGCVASLGCIIPNASACAMAG-QGQHAGSASALMGSL 343
Cdd:cd17503 238 LDKFGPR---LLLLAGLLLLALGTLLLAFLTPDTsLWLIILPLFIRGLGMGLVFMPLNTLALNSlPPEQIGDATALFNTI 314
|
330
....*....|....*
gi 15598769 344 QFSVAAGASALVGVL 358
Cdd:cd17503 315 RQLGGSIGTALLATL 329
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
28-358 |
3.81e-26 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 108.03 E-value: 3.81e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 28 PTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGC 107
Cdd:cd17321 20 PTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 108 AGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAglgvalwlpetipadg 187
Cdd:cd17321 100 AIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA---------------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 188 erpplsgalgqyrrLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYGWLFGSNAAGFIVMAQVNARLLR 267
Cdd:cd17321 164 --------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLAD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 268 YRGPafwLRRIIWGYLACGLALLGIASL-QPATLWPLLVPLFGCVASLGCIIPNASACAMAGQGQH-AGSASALMGSLQF 345
Cdd:cd17321 230 RFGP---RLVLVAGLLLTAVGLLLLALLgADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEkAGAASGILNTARQ 306
|
330
....*....|...
gi 15598769 346 SVAAGASALVGVL 358
Cdd:cd17321 307 LGGALGVALLGAL 319
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
23-382 |
1.75e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 106.12 E-value: 1.75e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 23 YLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQ 102
Cdd:cd17325 15 IIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 103 ALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALWLPET 182
Cdd:cd17325 95 GLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 183 IPA-DGERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYGWLFGSNAAGFIVMAQV 261
Cdd:cd17325 175 RPPpNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPP 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 262 NARLLRYRGPafwLRRIIWGYLACGLALLGIASLQPATLWPLLVPLFGCVASLGCIIPNASACAMAGQGqHAGSASALMG 341
Cdd:cd17325 255 AGKLSDRIGR---KPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE-GRGTAMGLFN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 15598769 342 SLQFSVAAGASALVGVLHD--GTAIPMTLVIAVCGAVATLLAW 382
Cdd:cd17325 331 TAFSLGMVLGPLLGGFLYDafGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
6-183 |
4.30e-25 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 104.96 E-value: 4.30e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 6 LLILGALSAFGPLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAA 85
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 86 CALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLT 165
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170
....*....|....*...
gi 15598769 166 LFAALAGLGVALWLPETI 183
Cdd:cd17323 161 IISGFCLILIFLFLPIVL 178
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
4-291 |
1.02e-24 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 102.58 E-value: 1.02e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 4 RILLILGALSAFGPLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLAS 83
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 84 AACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVc 163
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 164 LTLFAALAGLGVALWLPETipadgERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEH 243
Cdd:COG0477 173 INAPLGLLALVLRLRLPES-----RGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 15598769 244 YGWLFGSNAAGFIVMAQVNARLLRYRGPAFWLRRIIWGYLACGLALLG 291
Cdd:COG0477 248 LALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
7-302 |
7.36e-24 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 102.21 E-value: 7.36e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 7 LILGALSAFgpLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAAC 86
Cdd:PRK15403 21 LILYDFAAY--LTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAAT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 87 ALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTL 166
Cdd:PRK15403 99 LFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 167 FAALAGLGVALWLPETIPADGERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYGW 246
Cdd:PRK15403 179 MGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMTTSQFAW 258
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 15598769 247 LFGSNAAGFIVMAQVNARLLRYRGPAfwlrRIIWGylACGLALLGIASLQPATL-WP 302
Cdd:PRK15403 259 TQVPVFGAVIVANAIVARFVKDPTEP----RFIWR--AVPIQLVGLALLIVGNLlWP 309
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
7-382 |
1.19e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 100.70 E-value: 1.19e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 7 LILGALSAFGPLAIDFYL-PSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAA 85
Cdd:cd17324 1 LLALALAAFAIGTTEYVIqGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 86 CALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLT 165
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 166 LFAALAGLGVALWLPetiPADGERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYG 245
Cdd:cd17324 161 VLALLAALLLWRLLP---SLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAII 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 246 WLFGSNAAGFIVMAQVNARLLRYRGPafwlRRIIWGYLACGLALLGIASLqPATLWPLLVPLFGCVASLGCIIPNASACA 325
Cdd:cd17324 238 GLLLLFGVAGVVGSPLAGRLADRGGR----RALLIALLLLAAALLLLTLL-GPSPLLLLVGLVLWGLGFFAAHSALQTRV 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15598769 326 MAGQGQHAGSASAL-MGSLQFSVAAGASALVGVLHDGTAIPMTLVIAVCGAVATLLAW 382
Cdd:cd17324 313 LRLAPEARGLASSLyLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
4-380 |
1.75e-23 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 100.87 E-value: 1.75e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 4 RILLILGALSAFGPLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLAS 83
Cdd:PRK10473 3 RFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIAS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 84 AACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVC 163
Cdd:PRK10473 83 LLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 164 LTLFAALAGLGVALWLPETIPAdgERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEH 243
Cdd:PRK10473 163 MAAMGILVLLLSLFILKETRPA--RAPAASSKPRENSESLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGFSRGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 244 YGWLFGSNAAGFIVMAQVNARLLRYRGPafwlRRIiwgyLACGLALLGIASLQPATLWPLLVPLFG---CVASLGCIIPN 320
Cdd:PRK10473 241 YAIIMALTAGVSMTVSFSTPFALGIFKP----RTL----MLTSQVLFLAAGITLALSPSHAVSLFGitlICAGFSVGFGV 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 321 ASACAMAGQGQHAGSASALMGSLQFSVAAGASALVGVLhDGTAIPMTLVIAVCGAVATLL 380
Cdd:PRK10473 313 AMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAVL-GISAWNMLIGILIACSIVSLL 371
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
48-182 |
5.93e-22 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 90.79 E-value: 5.93e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 48 YFAGLSIGQLLYGPVA----DRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDP 123
Cdd:TIGR00880 3 LLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 15598769 124 IGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALWLPET 182
Cdd:TIGR00880 83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
6-349 |
1.23e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.79 E-value: 1.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 6 LLILGALSAFGPLAIDFYLPsfPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAA 85
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALP--LLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 86 CALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLT 165
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 166 LFAALAGLGVALWLPETIPADGERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYG 245
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 246 WLFGSNAAGFIVMAQVNARLLRYRGPAFWLRRIIWGYLACGLALLGIASLQPATLWPLLVPLFGCVASLGCIIPNASACA 325
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....
gi 15598769 326 MAGQgQHAGSASALMGSLQFSVAA 349
Cdd:pfam07690 319 LAPK-EERGTASGLYNTAGSLGGA 341
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-382 |
1.07e-19 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 89.54 E-value: 1.07e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 2 NLRILLILGALSAFGPLAIDFYLPSF--PTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIF 79
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVaaPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 80 TLASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQS 159
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 160 IFVCLTLFAALAGLGValwlpetipadgerpplsgalgqyrrlfadrlFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGI 239
Cdd:COG2271 166 AFLILGLPGLLLALLR--------------------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 240 PAEHYGWLFGSNAAGFIVMAQVNARLLRYRGPAFwlRRIIWGYLACGLALLGIASLQPATLWPLLVPLFGCVASLGCIIP 319
Cdd:COG2271 214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRR--KLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGL 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15598769 320 NASACAMAGQGQHAGSASALMGSLQFSVAAGASALVGVLHDGTAIPMTLVIAVCGAVATLLAW 382
Cdd:COG2271 292 LWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
6-382 |
2.78e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 85.56 E-value: 2.78e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 6 LLILGALSAFGPLAIDFYLPSfptLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAA 85
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPA---LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 86 CALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDW--QGWQSIFVC 163
Cdd:cd06174 78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 164 LTLFAALAGLGVALWLPET---IPADGERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIP 240
Cdd:cd06174 158 AAALALLAAILLLLVVPDPpesARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 241 AEHYGWLFGSNAAGFIVMAQVNARLLRYRgpaFWLRRIIWGYLACGLALLGIASLQPATLWPLLVPLFGCVASLGCIIPN 320
Cdd:cd06174 238 VAVAGLLLSLFGLAGALGSLLLGLLSDRL---IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLS 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15598769 321 ASACAMAGQGQHAGSASALMGSLQFSVAAGASALVGVLHDGTAIP--MTLVIAVCGAVATLLAW 382
Cdd:cd06174 315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLtgAFLVLAVLLLLAAILLL 378
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
3-382 |
7.48e-18 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 84.16 E-value: 7.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 3 LRILLILGALSAFGPLAIDfylPSFPTLAKAFATDVEH-VQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTL 81
Cdd:cd17473 1 LITLLLASTLTVMAGAAIA---PALPAIAQHFVPNSELlVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 82 ASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWqGWQSIF 161
Cdd:cd17473 78 GGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 162 VcLTLFAALAGLGVALWLPETIPADGERPPLSGALgqyRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPA 241
Cdd:cd17473 157 L-VYLLALPVLILVLLFLPEPARKSKSAASPGAAT---AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 242 EHYGWLFGSNAAGFIVMAQVNARLLRYRGPAFWLrRIIWGYLACGLALLGIASLQPATLWPLLVPLFGCvaslGCIIPNA 321
Cdd:cd17473 233 ALIGLALAIASLAGAIGALLFGRLKRRLGKRRLL-AIGFALMALGFLLLALASGLWVVLLGAILAGLGF----GLLLPTL 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15598769 322 SACAMAG-QGQHAGSASALMGSL----QFSVAAGASALVGVLHDGTAipMTLVIAVCGAVATLLAW 382
Cdd:cd17473 308 NSWAMSLvPPELRGRAMGIVTSAfflgQFLSPLVLGPLVNLTGGLSG--AFLILGVLALVLAIVLL 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
5-392 |
1.51e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 83.39 E-value: 1.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 5 ILLILGALSAFGPLAidfylpsfPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASA 84
Cdd:COG2223 14 FFLAFGVWYLWSVLA--------PPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 85 ACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCL 164
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 165 TLFAALAGLGVALWLPEtiPADGERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHY 244
Cdd:COG2223 166 GILLLVVAVLAWLFLRD--PPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 245 GWLFGSNAAGFIVMAQVNARLLRYRGPAFWLrriIWGYLACGLALLgIASLQPATLWPLLVPLFGCVASLGciIPNASAC 324
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRRVL---LIVFALMALGLL-LLALALGSLWLFLVLFLLLGLALG--GGNGAVF 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15598769 325 AMAGQ---GQHAGSASALMGSLQFSVAAGASALVGVLHDGTAIPMT--LVIAVCGAVATLLAWQTGRLERQAA 392
Cdd:COG2223 318 ALVPDifpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAafLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
2-391 |
2.59e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 79.90 E-value: 2.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 2 NLRILLILGALSAFGPLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTL 81
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 82 ASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLcDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQ---GWQ 158
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL-GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGlslSWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 159 SIFVCLTLFAALAGLGVALW-LPETIPADGERpplSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLY 237
Cdd:COG0738 165 LPYLILAVLLLLLALLFLRSkLPEIEEEEEEA---AGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 238 GIPAEHYGWLFGSNAAGFIVMAQVNARLLRYRGPafwlRRIIWGYLACGLALLGIASLQPaTLWPLLVPLFGCVASLGCI 317
Cdd:COG0738 242 GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP----VRLLRLSALLAAVGLLLALLAP-GPWLALIGLALVGLGLSLM 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598769 318 IPNASACAMAGQGQHAGSASALMGSLQFSVAAGASALVGVLHDGTAIPMTL-VIAVCGAVATLLAWQTGRLERQA 391
Cdd:COG0738 317 FPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFlVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
46-161 |
2.18e-15 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 76.45 E-value: 2.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 46 AAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIG 125
Cdd:cd17502 37 TAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRE 116
|
90 100 110
....*....|....*....|....*....|....*.
gi 15598769 126 AAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIF 161
Cdd:cd17502 117 RGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCF 152
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
26-185 |
6.20e-14 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 73.18 E-value: 6.20e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 26 SFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALG 105
Cdd:TIGR00711 24 AIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 106 GCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALWLPETIPA 185
Cdd:TIGR00711 104 GGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKPA 183
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
22-382 |
9.76e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 71.88 E-value: 9.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 22 FYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAP-----SLEWLI 96
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 97 AARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVA 176
Cdd:cd06173 97 VLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 177 LWLPETIPADGERPPL--SGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYGWLFGSNAAG 254
Cdd:cd06173 177 FIRRPPPAAPGESSSLllRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 255 FIVMAQVNARLLRYRGPafwLRRIIWGYLACGLALLGIASLQPATLWPLLVPLFGCVASLGcIIPNASACAMAGQGQHAG 334
Cdd:cd06173 257 ALLGALLLGRLSKRRRR---GRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLF-NVPLNTLLQLRVPDELRG 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 15598769 335 SASALMGSLQFSVAAGASALVGVLHDGTAIPMTLVIAVCGAVATLLAW 382
Cdd:cd06173 333 RVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
24-317 |
2.87e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 70.30 E-value: 2.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 24 LPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQA 103
Cdd:cd17504 16 SPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 104 LGGcAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALwlpetI 183
Cdd:cd17504 96 IGG-AVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPL-----I 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 184 PadgerpplsgalgqyRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQ----LYGIPAEHYGWLFGSNAAGFIVMA 259
Cdd:cd17504 170 D---------------LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAG 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 15598769 260 QVNARLLRYRGPAfwlRRIIWGYLACGLALLGIAsLQPATLWPLLVPLFGCVASLGCI 317
Cdd:cd17504 235 PLAGRLIARVGPR---RVLLIGLVISAVGLLLLA-LLHSSLWALVVALLLIGIGLGLA 288
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
54-386 |
3.33e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 70.29 E-value: 3.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 54 IGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCdPIGAAKAFSQL 133
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLY 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 134 MLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALWLPETIPAdgerPPLSGALGQYRRLFADRLFLAYGL 213
Cdd:COG2807 147 TAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA----AAAAPAAASLRSLWRSPLAWLLTL 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 214 SGGVAMAGMFAYIAGSPYVFIQLyGIPAEHYGWLFGSNAAGFIVMAQVNARLLRYRGPafwLRRIIWGYLACGLALLGIA 293
Cdd:COG2807 223 FFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGD---RRPLLLLLGLLGLAGLLGL 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 294 SLQPATLWPLLVPLFGCVASLGCIIPNASACAMAGQGQHAGSASALMGSLQFSVAAGASALVGVLHD--GTAIPMTLVIA 371
Cdd:COG2807 299 LLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDatGSWTAALLLLA 378
|
330
....*....|....*
gi 15598769 372 VCGAVATLLAWQTGR 386
Cdd:COG2807 379 ALAVLMLVAGLLAGR 393
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-323 |
4.21e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 70.32 E-value: 4.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 14 AFGPLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLS-----IGQLLYGPVAD----RYGRRLP-LLVGVSIFTLAS 83
Cdd:COG2211 16 GLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVArlwdaITDPLIGALSDrtrtRWGRRRPwILIGAIPLALSF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 84 AACALAPSLE------WLIAARFVQALGGCAGMVISRAVVRDLC-DPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDW-- 154
Cdd:COG2211 96 VLLFTAPDLSptgkliYALVTYLLLGLAYTLVNIPYSALGAELTpDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfg 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 155 ----QGWQSIFVCLTLFAALAGLGVALWLPETIPADGERPPLSGALgqyRRLFADRLFLAYGLSGGVAMAGMFAYIAGSP 230
Cdd:COG2211 176 gdaaLGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESL---KALLKNRPFLLLLLAYLLFFLALALVAALLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 231 YVFIQLYGIPAEHYGWLFGSNAAGFIVMAQVNARLLRYRGPafwLRRIIWGYLACGLALLGIASLQPATLWPLLVPLFGC 310
Cdd:COG2211 253 YYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGK---KKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALA 329
|
330
....*....|...
gi 15598769 311 VASLGCIIPNASA 323
Cdd:COG2211 330 GIGLGAILVLPWA 342
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
28-183 |
7.86e-12 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 66.23 E-value: 7.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 28 PTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGC 107
Cdd:TIGR00895 41 PAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLG 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15598769 108 AGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALWLPETI 183
Cdd:TIGR00895 121 GLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESI 196
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
54-382 |
1.01e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 65.71 E-value: 1.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 54 IGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQL 133
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 134 MLVMGLAPILAPVAGGLLLDwQGWQSIFVCLTLFAALAGLGVALWLPETIPADGERPPLSGALGqYRRLFADRLFLAYGL 213
Cdd:cd17329 130 YWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRG-YKIVLRDRAFLLFLL 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 214 SGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYGWLFGSNAAgFIVMAQVNARLLRYRGPAfwLRRIIWGYLACGLALLGIA 293
Cdd:cd17329 208 ASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNAL-LIVLLQFPVARLVERFRL--RKILMIGILLFAIGFAVLA 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 294 SLQpaTLWPLLvpLFGCVASLGCII--PNASACA--MAGQGQHAGSASALMGSLQFSVAAGaSALVGVLHD--GTAIPMT 367
Cdd:cd17329 285 FAN--TLAVLI--LAMIVLTLGEMLvfPAVQTLVaaLAPPDKRGSYMGFYALAWGLGRAIG-PLVGGLLLDllGPGLPWL 359
|
330
....*....|....*
gi 15598769 368 LVIAVCGAVATLLAW 382
Cdd:cd17329 360 ILAALGLIAAALLLG 374
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
28-382 |
1.33e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 65.28 E-value: 1.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 28 PTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGC 107
Cdd:cd17319 27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 108 AGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALWLpetipadg 187
Cdd:cd17319 107 GFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL-------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 188 erpplsgalgqyrrlfadRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYGWL----FGSNAAGFIVMAQVNA 263
Cdd:cd17319 179 ------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLaaipFLAGAIGMILGGRLSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 264 RLLRYRGpafwlRRIIWGYLACGLALLGIASLQpATLWPLLVPLFGCVASLGCIIPNASA-CAMAGQGQHAGSASALMGS 342
Cdd:cd17319 241 RLLRGAR-----RLVIIIGLLLAAVGLLLAYLT-TSPVVAVILLSLAGFGIGAASPVFWSlPADLLPGEAAATAGGLINS 314
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 15598769 343 LQFSVAAGASALVGVLHDGTAIPMT--LVIAVCGAVATLLAW 382
Cdd:cd17319 315 GGNLGGFVAPLLIGYLVDATGSYTAafLFLAAVALLAALLVL 356
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
28-382 |
2.38e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 64.57 E-value: 2.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 28 PTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARF-VQALGG 106
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFlVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 107 CAGMVISRAVVRDLCDpigaakafSQLMLVMGLAPILAPVAGGL---LLDW----QGWQSIFVCLTLFAALAGLGVALWL 179
Cdd:cd17475 100 SVQPGGGRAIMRWFPP--------RERGLAMGIRQTGVPLGGALaaaLLPPlalhYGWRAAFVVAGLVSILAAVLFWLFY 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 180 PETIPADGERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYGWLF----GSNAAGF 255
Cdd:cd17475 172 REPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLavaqLGGALGR 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 256 IVMAQVNARLLRYRGPafwlRRIIWGYLACGLALLGIASLQPATLWPLLVPLFgCVASLGCIIPNASACA----MAGQGQ 331
Cdd:cd17475 252 IGLGRVSDRVFGGRRR----PVLVITAAIAAAALLVLSLLSPGTPLWLLVLLL-ILLGLFAIGWNGLYLTlvaeSAGPEQ 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 15598769 332 hAGSASALMGSLQFSVAAGASALVGVLHDGTAIPMTLVIAVCGAVATLLAW 382
Cdd:cd17475 327 -AGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALL 376
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
43-376 |
2.39e-11 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 64.54 E-value: 2.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 43 LSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGCAGMVIsrAVVRDLCD 122
Cdd:cd17472 36 LALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSVVM--ALLADLTR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 123 PIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALWLPETIPADGERpplSGALGQYRRL 202
Cdd:cd17472 114 EENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQIS---EKEKKKLKKL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 203 FADRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYGWLFGSNAAGFIVMAQVnARLLRYRGPAFWLRRIIWGY 282
Cdd:cd17472 191 LKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPF-VIYAEKKGKMKQVFVSSILL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 283 LACGLALLGIASLQPATLWPLLVPLFGCVASLGCIIPnASACAMAGQGQHaGSASALMGSLQFSVAAGASALVGVLHD-- 360
Cdd:cd17472 270 IAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLP-SLVSKIAPKEYR-GTAMGIYNTSQFLGSFLGGALGGLLWGll 347
|
330
....*....|....*.
gi 15598769 361 GTAIPMTLVIAVCGAV 376
Cdd:cd17472 348 GYSSVFLTILILALLW 363
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
27-183 |
9.99e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 62.60 E-value: 9.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 27 FPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGG 106
Cdd:cd17365 22 APALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGL 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598769 107 CAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFvcltLFAALAGLGVALWLPETI 183
Cdd:cd17365 102 GAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVF----LLGGVPPLILLPLLRGTL 174
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
39-350 |
1.00e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 62.60 E-value: 1.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 39 EHVQLSLAAYFAGL-----SIGQLLYGPV----ADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGcAG 109
Cdd:cd17330 25 EFNKLGASGYYVGLlqssySLGQFLASPLwgrlSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTG-GN 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 110 MVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALWLPETIpadger 189
Cdd:cd17330 104 VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLR------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 190 pplsgalgqyrrlfadRLFLAYGLSggvaMAGMFAYIAGSPYVFIQLYGIPAEHYGWLFGSNAAGFIVMAQVNARLLRYR 269
Cdd:cd17330 178 ----------------RLLLVYFLI----ALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 270 GPAFWLRRIIWGYLACGLALLGIASLQPatlwplLVPLFGCVASLGCIIPNASACAMAGQGQHAGSASALMGSLQFSVAA 349
Cdd:cd17330 238 LGERKLLRLGLLLAIIGLLLLPFASSVP------LLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSL 311
|
.
gi 15598769 350 G 350
Cdd:cd17330 312 A 312
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
4-382 |
1.80e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 61.90 E-value: 1.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 4 RILLILGALSAFGPLAIDFYLPSF-PTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLA 82
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFiIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 83 SAACALAPSLEWLIAARFVQALGGCAGMVISR-AVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIF 161
Cdd:cd17355 82 LVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 162 VCLTLFAALAGLGVALWL----PETIPADGERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAGMFAYIAGSPyVFIQLY 237
Cdd:cd17355 162 LVLALLALLVLVPVLLLLrrrpADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLV-PYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 238 GIPAEHYGWLFGSnAAGFIVMAQVNARLLRYRGPAFWLRriIWGYLACGLALLGIASLQPATLWPLLVPLFGCVASLGCI 317
Cdd:cd17355 241 GISPAAAAVALAL-IGLFNIVGRLLSGWLGDRYSPRRLL--AASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598769 318 IPNASACAMAGQGQHAGSASALMGSLQFSVAAGASALVGVLHDGTAI--PMTLVIAVCGAVATLLAW 382
Cdd:cd17355 318 PLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSytAAWALAVALGLIAALLVL 384
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
13-382 |
2.63e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.46 E-value: 2.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 13 SAFGPLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSL 92
Cdd:cd17489 5 NFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 93 EWLIAARFVQALG-GCAGMVISrAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFvCLTLFAALA 171
Cdd:cd17489 85 ALLLVLRLIHGIGwGAFTTAAA-TLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLF-IVAAVLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 172 GLGVALWLPETIPADGERPPLSgalgqyrRLFADRLFLAYGLSGGVAMAGM-FAYIAGSPYVFIQLYGIPAEHYGWLFGS 250
Cdd:cd17489 163 ALLLVFLVKDPPPVAAEEAEAG-------TRAFRRLVEKKVLPPALILFLAsIAYGAISTFLPLYAAERGISNAGLFFTV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 251 NAAGFIVMAQVNARLLRYRGPAFWlrrIIWGYLACGLALLGIASLQPATLWPLLVPLFGCVASLGCIIPNASACAMAGQG 330
Cdd:cd17489 236 YAIALLLSRPFSGKLSDRKGPKTV---IIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPH 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15598769 331 QHAGSASALMGSLQFSVAAGaSALVGVLHDGTAIPMT-LVIAVCGAVATLLAW 382
Cdd:cd17489 313 RRGAANGTFFIFFDLGIGLG-GLLLGLVAELFGYRAMfLLAAVVVLLALVLYI 364
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
3-307 |
3.04e-10 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 61.11 E-value: 3.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 3 LRILLILGALSAFGplaIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPV----ADRYGRRLPLLVGVSI 78
Cdd:cd17388 1 LIFILVTVLLDAMG---IGLIMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPIlgalSDRFGRRPVLLLSLAG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 79 FTLASAACALAPSLEWLIAARFVQALGGCAGMVISrAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWqGWQ 158
Cdd:cd17388 78 AALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAA-AYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 159 SIFVCLTLFAALAGLGVALWLPETIPADGERPPLSGALGQYRRLFADRLFlaYGLSGGVAMAGMFAYIAGSPYVFIQLYG 238
Cdd:cd17388 156 APFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGF--PGLLGLLAVFFLIQLIGQVPATTWVLFT 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15598769 239 IpaEHYGW---LFGSNAAGFIVM-AQVNARLLRYRGPAFWLRRIIWGYLA---CGLALLGIASlQPATLWPLLVPL 307
Cdd:cd17388 234 E--DRFDWsptMVGLSLAVFGLLhALFQAFVTGPIAKRLGEKRAILLGLAadaLGFLLLAFAT-QGWMVFPILILL 306
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
2-179 |
1.24e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.13 E-value: 1.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 2 NLRILLILGALSAFGPLAIDFYLPSFptLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTL 81
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLY--AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 82 ASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIF 161
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
170
....*....|....*...
gi 15598769 162 VCLTLFAALAGLGVALWL 179
Cdd:cd17325 358 LAAAALLLLAAVLFLLLR 375
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
19-382 |
4.62e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 57.61 E-value: 4.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 19 AIDFYLPSF--PTLAKAF--ATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEW 94
Cdd:cd17316 12 AYDFFLIGFvaPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPIL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 95 LIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLL----DWQGWQSIFvcltLFAAL 170
Cdd:cd17316 92 LLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllsGDWGWRILF----LIGAL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 171 AGLGVALWLpetipadgerpplsgalgqyrrlfadRLFLAYGLSGGVAMAGMFAYIAGSPYVFIQLYGIPAEHYGWLFGS 250
Cdd:cd17316 168 PALLALLLR--------------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 251 NAAGFIVMAQVNARLLRYRGPafwlRRIIWGYLACGLALLGIASLQPATLWPLLVPLFGCVASLGCIIPNASACAMAGQ- 329
Cdd:cd17316 222 ISLGALVGALIAGLLSDRIGR----KKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELf 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 15598769 330 -GQHAGSASALMGSLQFSVAAGASALVGVLHDGT-AIPMTLVIAVCGAVATLLAW 382
Cdd:cd17316 298 pTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTgGTGVPALILALLAIVALIVA 352
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-182 |
7.52e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 56.80 E-value: 7.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 2 NLRILLILGALSAFGPLAIDFYLPSFptLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRR--LPLLVGVSIF 79
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTY--LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 80 TLASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQS 159
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|...
gi 15598769 160 IFVCLTLFAALAGLGVALWLPET 182
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRET 361
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
28-206 |
2.53e-08 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 55.35 E-value: 2.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 28 PTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGC 107
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 108 AGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALWLPETIPADG 187
Cdd:PRK11551 119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQ 198
|
170
....*....|....*....
gi 15598769 188 ERPPLSGALGQYRRLFADR 206
Cdd:PRK11551 199 AAGAGKQRAPVLRALFGEG 217
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
50-182 |
6.60e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 53.85 E-value: 6.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 50 AGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKA 129
Cdd:cd17371 45 AGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKA 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 15598769 130 FSQLMLV----MGLAPILAPVAGGLLLDWQGWQSIFVcLTLFAALAGLGVALWLPET 182
Cdd:cd17371 125 LGYVQSGwavgWLLATLLAALLFPLLPPEIAWRVLFL-LGALPALLVLFIRRFVKEP 180
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
40-167 |
1.76e-07 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 52.58 E-value: 1.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 40 HVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRD 119
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 15598769 120 LCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQ------GWQSIFVCLTLF 167
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRwlqlaiSLPGLLFLLLLW 159
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
26-179 |
3.34e-07 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 52.04 E-value: 3.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 26 SFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALG 105
Cdd:PRK10504 32 ALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVG 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15598769 106 GCAGMVISRAVVRDLC--DPIGAAKAFSQLMLVMGlaPILAPVAGGLLLDWQGWQSIFVcLTLFAALAGLGVALWL 179
Cdd:PRK10504 112 GAMMVPVGRLTVMKIVprEQYMAAMTFVTLPGQVG--PLLGPALGGLLVEYASWHWIFL-INIPVGIIGAIATLML 184
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
43-182 |
9.35e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 50.27 E-value: 9.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 43 LSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALG-GCAGMV-------ISR 114
Cdd:cd17315 38 LVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGvGLASVLvplyiseIAP 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598769 115 AVVRdlcdpiGAAKAFSQLMLVMGLapILAPVAG-GLLLDWQGWQSIFVCLTLFAALAGLGVALWLPET 182
Cdd:cd17315 118 AKIR------GALGTLNQLMITFGI--LLAYLLGlALSLSPPGWWRLMFALAAVPALLQLLLMFFLPES 178
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
27-182 |
9.40e-07 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 50.26 E-value: 9.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 27 FPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGG 106
Cdd:cd17359 24 LPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 107 CAGMVISRAVVRDLCDPI--GAAKAFSQLMLVMGLAP------ILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVaLW 178
Cdd:cd17359 104 GGASALVPMYIAEVAPAEirGRLVSLNQLMIVFGQLLayivnyLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGM-LF 182
|
....
gi 15598769 179 LPET 182
Cdd:cd17359 183 IPES 186
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
43-309 |
1.27e-06 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 50.01 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 43 LSLAAYFAGLSIGQLLYGPVADRYGRR-----LPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGCAGMVISRAVV 117
Cdd:TIGR00900 38 LAALAGMLPYVVLSPIAGALADRYDRKkvmigADLIRAVLVAVLPFVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAML 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 118 RDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALWLPETIPADGERPPLSGALG 197
Cdd:TIGR00900 118 PDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIWVDAVGFAISALLIVSVRIPELAASEIQALSNAVLR 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 198 QYRR----LFADRLFLAYGLSGGVAMA-GMFAYIAGSPYVFIQLYGIPAEHYGWLFGSNAAGFIVMAQVNARLLRYRGPA 272
Cdd:TIGR00900 198 DTREgikfVLKNPLLRTLLLLALLFNLvFAPAIVALFPYVQSKYLGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFKRM 277
|
250 260 270
....*....|....*....|....*....|....*..
gi 15598769 273 FWlrriIWGYLACGLALLGIASLQPATLWPLLVPLFG 309
Cdd:TIGR00900 278 AL----MTGAIFVIGLAILVVGLTPPNFPLFLVLWFA 310
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
10-182 |
3.90e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 48.81 E-value: 3.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 10 GALSAFGPLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALA 89
Cdd:pfam00083 17 GVIGAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 90 P---SLEWLIAARFVQALG-----GCAGMVISRAVVRDLCdpiGAAKAFSQLMLVMG--LAPILApVAGGLLLDWQGWQs 159
Cdd:pfam00083 97 KgkwSVYQLIVGRVLVGIGvggasVLAPMYISEIAPKKLR---GALGSLYQLAITFGilLAYIFG-LGLNKTSNSDGWR- 171
|
170 180
....*....|....*....|...
gi 15598769 160 IFVCLTLFAALAGLGVALWLPET 182
Cdd:pfam00083 172 IPLGLQLVPALLLIIGLLFLPES 194
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
3-175 |
1.83e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.38 E-value: 1.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 3 LRILLILGALSAFGPLAIDFYLpsfpTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLA 82
Cdd:cd17370 202 FWLYLLAVALFALGNFSFAFLI----LRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 83 SAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFV 162
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFL 357
|
170
....*....|...
gi 15598769 163 CLTLFAALAGLGV 175
Cdd:cd17370 358 FSAVLALIALLLL 370
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
14-381 |
2.07e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.01 E-value: 2.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 14 AFGPLAIDFY----LPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALA 89
Cdd:cd17478 2 SLGHFLNDFYqgflPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 90 PSLEWLIAARFVQALGGCAGMVISRAVVRDLCDP-IGAAKAFSQLMLVMGLApiLAPVAGGLLLDWQGWQSIFVcLTLFA 168
Cdd:cd17478 82 PNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGrRGLAMSIFSVGGNLGFA--LGPLIAAALVALFGGLGLLI-LLIIP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 169 ALAGLGVALWLPETIPADGERPPLSGALGQYRRLFADRLFLAYGLSGGVAMAgMFAYIAGSPYVFIQLYGIPAE---HYG 245
Cdd:cd17478 159 GLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWV-LSSLTTFLPFYLVQRGYSLVFaglLLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 246 WLFGSNAAGFIVMAQVNARLLRyrgpafwlRRIIW-GYLACGLALLGIASLQPATLWPLLVPLFGCVASlgciipNASAC 324
Cdd:cd17478 238 LFLFAGAIGTLIGGPLSDRFGR--------RRVIIaSLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFA------SFPVT 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 325 AMAGQG---QHAGSASALMGSLQFSVAAGASALVGVLHDGTAIPMTLVIAVCGAVATLLA 381
Cdd:cd17478 304 VVLAQEllpGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALL 363
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
60-211 |
2.37e-05 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 46.26 E-value: 2.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 60 GPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGgcAGMVI--SRAVVRDL-CDPIGAAKAFSQLMLV 136
Cdd:PRK14995 62 GALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIG--AAMIVpaTLAGIRATfTEEKQRNMALGVWAAV 139
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598769 137 MGLAPILAPVAGGLLLDWQGWQSIFVcLTLFAALAGLGVALWLpetIPADGERPPLSGALGQYRRLFADRLFLAY 211
Cdd:PRK14995 140 GSGGAAFGPLVGGILLEHFYWGSVFL-INVPIVLVVMGLTARY---VPRQAGRRDQPLNLGHALMLIVAILLLVY 210
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
40-317 |
6.85e-05 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 44.58 E-value: 6.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 40 HVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLV-----GVSIFTLASAACALAPSLEWLIAARFVQALGGCAGMVISR 114
Cdd:PRK10489 53 QVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLargtcGLGFIGLALNAFLPEPSLLAIYLLGLWDGFFGSLGVTALL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 115 AVVRDLC--DPIGAAKAFSqlMLVMGLAPILAPVAGGLLLDWQGWQSIFVcLTLFAALAGLGVALWLPETIPADGER-PP 191
Cdd:PRK10489 133 AATPALVgrENLMQAGAIT--MLTVRLGSVISPALGGLLIAAGGVAWNYG-LAAAGTFITLLPLLRLPALPPPPQPReHP 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 192 LSGALGQYRRLFADRLFlayglsGGVAMAGMFAYIAGSPYVFI-----QLYGIPAEHYGWLFGSNAAGFIVMAQVNARLL 266
Cdd:PRK10489 210 LRSLLAGFRFLLASPVV------GGIALLGGLLTMASAVRVLYpaladEVWQMGAAQIGLLYAAVPLGAALGALTSGWLA 283
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 15598769 267 RYRGPAFWLrriiwgYLACGLALLGIASLQPATLWPLLVPLFGCVASLGCI 317
Cdd:PRK10489 284 HSARPGLLM------LLSTLGSFLAVGLFGLMPMWILAVLCLALFGYLSAI 328
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
26-182 |
7.51e-05 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 44.49 E-value: 7.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 26 SFPTLAKAFATDVEHVQLSLAAY--FAGLS-----IGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAA 98
Cdd:cd17358 21 SSPALPSLMSDNSLSLPLTVAQFswFGSLLtlgalIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 99 RFVQALGGCAGMV--------ISRAVVRdlcdpiGAAKAFSQLMLVMGlapILAPVAGGLLLDWQgWQSIFVCLTLFAAL 170
Cdd:cd17358 101 RFLAGFGGGAASVvvpvyiaeIAPKNVR------GALGSLNQLLVNIG---ILLGYVLGSFLPWR-TLALIGAIPPVVFL 170
|
170
....*....|..
gi 15598769 171 AGLgvaLWLPET 182
Cdd:cd17358 171 ILL---FFIPES 179
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
18-379 |
7.86e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 44.23 E-value: 7.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 18 LAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIA 97
Cdd:cd17333 10 LTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 98 ARFVQALGGCAGMVISRAVVRDLcdpigAAKAFSQLMLVM----GLAPILAPVAGGLLLDWQ-GWQSIFVCLTLFAAlag 172
Cdd:cd17333 90 LMFLAGLGAGILDTGANTFVGAL-----FEESSATRLNVLhgffGLGALIGPLIATSLLTSElSWSWAYLIIGLIYL--- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 173 LGVALWLPETIPADGERPPLSGALGQYRRLFADRLFLAYGLSGGVAmAGMFAYIAGSPYVFIQLYGIPAEHYGWLFGSNA 252
Cdd:cd17333 162 LLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALA-LFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 253 A-----GFIVMAQVNARLLRYRGPafwlRRIIWGYLACGLALLGIASLQPATLWpLLVPLFGCVASLGCIIPNASACAMA 327
Cdd:cd17333 241 LsgfwvGITIGRLLGGPISRRIKP----HTLLVLSGSGALLGLLILLLAPTLVV-GLVATALLGLFMAALFPTILSLGIS 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15598769 328 GQGQHAGSASALMGSLQFSVAAGASALVGVL--HDGTAIPMTLVIAVCGAVATL 379
Cdd:cd17333 316 NLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIaeAVGIQTAMLLITILYAIIFVL 369
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
45-179 |
8.17e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 44.47 E-value: 8.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 45 LAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAP--SLEWLIAARFVQALGGCAGM-----VISRAVV 117
Cdd:cd17380 40 LSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAysSLPLLILSRILLGLGEGVHFpsmtsLFSRWVP 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15598769 118 RDlcdpiGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVcltLFAALAGLGVALWL 179
Cdd:cd17380 120 VS-----ERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFY---FFGLLGLLWALVWL 173
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
48-101 |
1.06e-04 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 43.82 E-value: 1.06e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 15598769 48 YFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFV 101
Cdd:cd17374 44 FMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFL 97
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
50-112 |
1.23e-04 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 43.80 E-value: 1.23e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15598769 50 AGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALG-GCAGMVI 112
Cdd:cd17360 46 AGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGvGIASMTV 109
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
17-113 |
1.45e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 43.85 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 17 PLAIDFYLPSFPTLAKAFAT-------DVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALA 89
Cdd:TIGR00898 98 EPCLDGWEYSYDTFSSTIVTewdlvceDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFS 177
|
90 100
....*....|....*....|....
gi 15598769 90 PSLEWLIAARFVQALGGCAGMVIS 113
Cdd:TIGR00898 178 PNYTVFLVFRLLVGMGIGGIWVQA 201
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
3-179 |
1.48e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.74 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 3 LRILLILGALSAFGPLAIDFYLPSFptLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLA 82
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYY--FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 83 SAACALAP--SLEWLIAARFVQALGGCAGMVISRAVVRDLCDPI-------GAAKAFSQLMLVMGLAPILAPVAGGLLLD 153
Cdd:COG2211 308 LLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
170 180 190
....*....|....*....|....*....|....*..
gi 15598769 154 WQGWQS-----------IFVCLTLFAALAGLGVALWL 179
Cdd:COG2211 388 LFGYVAgaaqspsaltgIRLLFFLLPAVLLLLAALLL 424
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
21-184 |
1.48e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 43.92 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 21 DFYLPSF--PTLAKAFA-TDVEHVQLSLAAyFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIA 97
Cdd:PRK03893 35 DFVLITLvlTEVQGEFGlTTVQAASLISAA-FISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 98 ARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFvcltlFAALAGLGVAL 177
Cdd:PRK03893 114 ARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALF-----FIGILPIIFAL 188
|
....*..
gi 15598769 178 WLPETIP 184
Cdd:PRK03893 189 WLRKNLP 195
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
41-100 |
1.76e-04 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 43.23 E-value: 1.76e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 41 VQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARF 100
Cdd:cd17377 41 VSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRF 100
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
54-181 |
1.87e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 43.11 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 54 IGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPI--GAAKAFS 131
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHirGLLVSLK 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 15598769 132 QLMLVMGLapILAPVAGGLLLD-WQGWQSIFVCLTLFAALAGLGVaLWLPE 181
Cdd:cd17362 134 ELFIVLGI--LLGYVSGYAFADvVGGWRYMYGLAAPPALLLGIGM-WFLPP 181
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
3-179 |
1.94e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.99 E-value: 1.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 3 LRILLILGALSAFGPLAIDFYLPSFptLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLA 82
Cdd:cd06173 210 LRLLLLALALFALLGGALTVLLPLL--AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 83 SAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFv 162
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF- 366
|
170
....*....|....*..
gi 15598769 163 cltLFAALAGLGVALWL 179
Cdd:cd06173 367 ---LLAGALLLLAALLL 380
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
60-295 |
2.05e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.98 E-value: 2.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 60 GPVADRYGRRLPLLVGVSIFT-LASAACALAPSLEWLIAARFvqALGGCAGMVISRAVV-RDLCDPIGAAKAFSQLMLVM 137
Cdd:cd17490 52 GILSDRIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARF--LSGIAAATWVSFTVLyASYFPPDEAAKAMGLINLVN 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 138 GLAPILAPVAGGLLLDWQGWQSIFVcLTLFAALAGLGVALWLPETIPadgERPPLSGALGQYRRLFADRLFLAYGLSGGV 217
Cdd:cd17490 130 NLGQLIAFLIGGLIAEHFGMRAPFL-LAALAGVLGFILSLFIKEERR---EKKPVLTELKELLSVLKDKKLLFFSLLAIL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 218 AMAGMFAYIAGSPYVFIQLYGIPAEHYGWLfgSNAagFIVMAQVNARL-----LRYRGPAFWlrrIIWGYLACGLALLGI 292
Cdd:cd17490 206 QQMITFSTTFGFTPLIAKQLGASSFQLGLL--SII--YLLPNALASLLsgtlfYKKLGERNT---IIIGFLLLGAYCFLI 278
|
...
gi 15598769 293 ASL 295
Cdd:cd17490 279 PFA 281
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-140 |
2.54e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.65 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 3 LRILLILGALSAFGPLAIDFYLPSFptLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLA 82
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLY--LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 15598769 83 SAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLA 140
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
29-112 |
5.96e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 41.86 E-value: 5.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 29 TLAKAFATDVEHVQLSL------AAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASA---ACALAPSLEWLIAAR 99
Cdd:cd17357 33 TLVDRYGLNLSDSELDLlwslivSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLlmfLSKSAKSPELLIFGR 112
|
90
....*....|...
gi 15598769 100 FVQALGGCAGMVI 112
Cdd:cd17357 113 FLVGIACGLSTGF 125
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
51-181 |
7.11e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 41.45 E-value: 7.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 51 GLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAF 130
Cdd:cd17328 46 SYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRAL 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 15598769 131 SQLMLVMGLAPILAPVAGGLLLDWQ-GWQSIFVCLTLFAALAGLGVALWLPE 181
Cdd:cd17328 126 GVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVRE 177
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
8-356 |
9.49e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 9.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 8 ILGALSAFGpLAIDFYLPSFPTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACA 87
Cdd:cd17477 1 LLLSVALLG-LGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 88 LAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGlLLDWQGWQSIFVCLTLF 167
Cdd:cd17477 80 LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA-LVGTAGALPFLIAAVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 168 aaLAGLGVALWLPETIPADGERPPLsgalgqyrrlfadRLFLAYGLS-GGVAMAGMFAYIAGSPYVFIQLYGIPAehygW 246
Cdd:cd17477 159 --LLALVPLLLTRRAAPEIEEAESI-------------SLRRLLRIApLALLGAFVAGFLEGAFYSLLPLYGLRL----G 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 247 LFGSNAAGFIVMAQVNARLLRYrgPAFWL------RRIIWGYLACGLALLGIASLQPATLWPLLVPLFgcvaSLGCIIPN 320
Cdd:cd17477 220 LSVAQAALLLAAFVLGGLLLQW--PLGWLadrfdrRRVLLGCALLGALAALLLPLVPGLPLALLVLLF----LWGGAAGP 293
|
330 340 350
....*....|....*....|....*....|....*.
gi 15598769 321 ASACAMAGQGQHAGSASALMGSLQFSVAAGASALVG 356
Cdd:cd17477 294 LYTLALALAGDRLPGDELVAANAALLLLYGLGSVIG 329
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
54-259 |
1.20e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 40.67 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 54 IGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALggCAGMVISRAVVRDLCDPIGAAKAFSQL 133
Cdd:cd17331 50 VGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVF--MHAMQAAQMVVTDLTDPGERAAALGRL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 134 MLVMGLAPILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALWLP-------ETIPADGERPPLSGALGQYRRLFADR 206
Cdd:cd17331 128 GLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPsntkskrEKEAKESASPPSVFNLKEILRLLRLP 207
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 207 LF-------LAYGLSGGVAMAgMFAYIAgspyvfIQLYGIPAEHYGWLFgsNAAGFIVMA 259
Cdd:cd17331 208 GVaflllvkLLSGLPIGMFQS-MFSLVA------MDFFGLTPEENGYLM--SYAGVLGMV 258
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
45-179 |
1.27e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 40.68 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 45 LAAYFAGLSIGQLLYGPVADRYGRRLPLLVGV---SIFTLASAACALApSLEWLIAARFVQALGGCAGMVISRAVVRDLC 121
Cdd:cd17318 62 LSSFFYGYILTQIPGGYLAEKYGAKRVLGYSIlitALLTLLTPLAARG-GYGALIVLRILQGLAQGVTFPAMHALWAKWA 140
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 15598769 122 DPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIFVcltLFAALAGLGVALWL 179
Cdd:cd17318 141 PPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFY---IFGGLGLLWCLLWF 195
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
2-178 |
1.74e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.29 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 2 NLRILLILGALSAFGPLAIDFYLPsfptlakAFATDVEHVQLSLAAYFAGLS-----IGQLLYGPVADRYGRRLPLLVGV 76
Cdd:cd17329 201 AFLLFLLASFLISLIYFQLESTLP-------VYVVEILGLGESLLGLLLALNallivLLQFPVARLVERFRLRKILMIGI 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 77 SIFTLASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQG 156
Cdd:cd17329 274 LLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG 353
|
170 180
....*....|....*....|..
gi 15598769 157 WQSIFVCLTLFAALAGLGVALW 178
Cdd:cd17329 354 PGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
28-179 |
1.77e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.94 E-value: 1.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 28 PTLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALGGc 107
Cdd:cd17476 22 PIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGP- 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598769 108 AGMVISRAVVRDLCDPIGAAKAFSqLMLVMGLAP---ILAPVAGGLLLDWQGWQSIFVCLTLFAALAGLGVALWL 179
Cdd:cd17476 101 AFLLPNAMALLGRTYPPGPRKNIV-FSLFGATAPlgfALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFWT 174
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
57-381 |
2.29e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 40.12 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 57 LLYGPVADRYGRRLPLLVGVSIFTLASAACAL-------APSLewLIAARFVQALGGCAGMVISRAVVRDLC--DPIGAA 127
Cdd:pfam05977 63 IPAGALADNFDRRKIMLAGQLLLALVSTLLTLlaglgllSPWL--LLGLTFLGGIGTALMDPAWQASVPELVprRDLPAA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 128 KAFSQLMLvmGLAPILAPVAGGLLLDWQG--WQSIFVCLTLFAALAGLgvALWLPETIPADGERPPLSGALGQYRRlfad 205
Cdd:pfam05977 141 VALNSVGY--NIARSVGPALGGVLLAAFGpaFTFALNALSYFAVIAAL--WRWKRAAPASPLPRERIFGAVRAGLR---- 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 206 rlFLAYGLSGGVAMAGMFAYIAGS-------PYVFIQLYGIPAEHYGWLFGSNAAGFIVMAQVNARLLRYRGPAfwlRRI 278
Cdd:pfam05977 213 --FTAMSRELRSVLVRAFAFGLSAsavwallPLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSD---RLV 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 279 IWGYLACGLALLGIASLQPATLwPLLVPLFGCVASLGCIIPNASACAMAGQGQHAGSASALMGSLQFSVAAGASALVGVL 358
Cdd:pfam05977 288 LLASVVTALVLLSLALAPNLWL-AIPVLLLGGAAWITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAV 366
|
330 340
....*....|....*....|...
gi 15598769 359 HDGTAIPMTLVIAVCGAVATLLA 381
Cdd:pfam05977 367 AEALSVTGALLGAAAALLAGAAA 389
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
3-178 |
2.61e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 3 LRILLILGALSAFGPLAIDFYLPSFptLAKAFATDVEHVQLSLAAYFAGLSIGQLLYGP-VADRYGRRLPLLVGVSIFTL 81
Cdd:cd17474 200 LLTFLVSAFLYFFLYFAFLTYLPFL--LELLYGISPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 82 ASAACALAPSLEWLIAARFVQALGGCAGMVISRAVVRDLCDPIGAAKAFSQLMLVMGLAPILAPVAGGLLLDWQGWQSIF 161
Cdd:cd17474 278 SLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPF 357
|
170
....*....|....*..
gi 15598769 162 VCLTLFAALAGLGVALW 178
Cdd:cd17474 358 LVGAAIALAAAVLLALL 374
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
43-182 |
3.01e-03 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 39.63 E-value: 3.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 43 LSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVgVSIFTLASAAC----ALAPSLEWLIAARFVQAL--GGCAGMV----- 111
Cdd:cd17431 54 LSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLY-NNLLAFAGAALmglsKLAKSYEMLILGRFIIGLycGLTTGLVpmyig 132
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15598769 112 -ISRAVVRdlcdpiGAAKAFSQLMLVMGLapILAPVAG--GLLLDWQGWQSIFVClTLFAALAGLGVALWLPET 182
Cdd:cd17431 133 eISPTALR------GALGTLHQLGIVVGI--LISQIFGleFILGTEELWPLLLGF-TIVPAILQLALLPFCPES 197
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
41-105 |
3.12e-03 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 39.57 E-value: 3.12e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15598769 41 VQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPS------LEWLIAARFVQALG 105
Cdd:cd17364 41 SGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFLLGIG 111
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|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
146-380 |
3.33e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 39.13 E-value: 3.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 146 VAGGLLL---DWQGWQSIFVCLTLFAALAGLGVaLWLPETIPADGERPPLSGA--LGQYRRLFADR-------LFLAYGL 213
Cdd:cd17485 143 LGGGGLLwlyDLIGWQSLLLSLAALYLLLLLPV-LFLRELELPQQPPASERGAalKASLRAFLRRPgtrwlllFLLLYKL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 214 SGGVAMAGMFAYIAGspyvfiqlYGIPAEHYGWLFGSNAAGF-IVMAQVNARLLRYRGPAFWLRRIIWGYLACGLALLGI 292
Cdd:cd17485 222 GEQGALAMLPPFLVD--------RGFSLSQIGLLSGVGGSLVsIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLL 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 293 ASLQPATLWPLLVPLFGCVASLGCIIPNASACAM--AGQGQHAGSASALMGSLQFSVAAGASALVGVLHDGTAIPMTLVI 370
Cdd:cd17485 294 ALGGSGLNWVLLLASLALLHLVGGMITTALFTLMmdCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLL 373
|
250
....*....|
gi 15598769 371 AVCGAVATLL 380
Cdd:cd17485 374 FAILSALSVL 383
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
53-382 |
4.11e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 4.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 53 SIGQLLYGPVADRYGRRLPLLV-GVSIFTLASAACALAPSLEWLIAARFVQALGgcAGMVIS--RAVVRDLCDPIGAAKA 129
Cdd:cd17370 48 SLLRLFSGYLSDRTGKRKPLVIlGYGLSALAKPLLALAGSWQLVLLLRILERLG--KGIRTPprDALLADATPPSGRGKA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 130 FSQLMLVMGLAPILAPVAGGLLLDWQGW--QSIFVCLTLFAALAGLGVALWLPETIPADGERPPLSGalGQYRRLfaDRL 207
Cdd:cd17370 126 FGLHRALDTLGAVLGPLLAALLLYLLGGnyRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKK--TSLKKL--PKA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 208 FLAYGLSGGVAMAGMFAYI---------AGSPYVFIQLYGIpaehygwlfgsnAAGFIVMAQVNARLLRYRGPAFWLrrI 278
Cdd:cd17370 202 FWLYLLAVALFALGNFSFAflilraqelGLSAALIPLLYAL------------FNLVYALAAYPAGRLSDRIGRKKL--L 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 279 IWGYLACGLALLGIASLQPATLWPLLVPLFGCVASLGCIIPNASACAMAGQGQHAGSasalMGSLQFSVAAG---ASALV 355
Cdd:cd17370 268 ILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTA----YGLFNTVVGIGwllASLIA 343
|
330 340
....*....|....*....|....*..
gi 15598769 356 GVLHDGTAIPMTLVIAVCGAVATLLAW 382
Cdd:cd17370 344 GYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
42-113 |
4.31e-03 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 38.94 E-value: 4.31e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15598769 42 QLSLAAYFAGLSIGQLLYGPVADRYGRRlPLLVGVSIFTLASAAC-ALAPSLEWLIAARFvqalggCAGMVIS 113
Cdd:cd17446 36 QLAQSIYMAGVLVGAIVFGGLSDRFGRR-PLLIWSYLQMAVSGTCaAFSPSFPIYCVFRF------LTGMALS 101
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
53-178 |
5.91e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.76 E-value: 5.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598769 53 SIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAArfvQALGGCAG--MVISRAVVRDLCDPIGAAKAF 130
Cdd:cd06179 46 AVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGG---QALIGIGAgtQGLGAAVASELVPNKYRGLVQ 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 15598769 131 SQLMLVMGLAPILAPVAGGLLL--DWQGWQSIFVCLTLFAALAGLGVALW 178
Cdd:cd06179 123 GVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYINAIFNALALILLFFF 172
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
41-105 |
8.89e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 37.90 E-value: 8.89e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598769 41 VQLSLAAYFAGLSIGQLLYGPVADRYGRRLPLLVGVSIFTLASAACALAPSLEWLIAARFVQALG 105
Cdd:cd17372 36 VALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLG 100
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|
| |
