|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
1-397 |
0e+00 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 856.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 1 MVEPQEGKTRFHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKER 80
Cdd:PRK01297 79 VVEPQEGKTRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKER 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 81 YMGEPRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDMV 160
Cdd:PRK01297 159 YMGEPRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDMV 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 161 EVMVLDEADRMLDMGFIPQVRQIIRQTPHKGERQTLLFSATFTDDVMNLAKQWTVDPAIVEIEPENVASDTVEQHVYAVA 240
Cdd:PRK01297 239 EVMVLDEADRMLDMGFIPQVRQIIRQTPRKEERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAVA 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 241 GSDKYKLLYNLVAQNNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRG 320
Cdd:PRK01297 319 GSDKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRG 398
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 308154507 321 IHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGTSISFAGEDDAFALPPIEELLGRKITCEMPPAELLKPVPRKH 397
Cdd:PRK01297 399 IHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEELLGRKISCEMPPAELLKPVPRKH 475
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
8-397 |
0e+00 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 546.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 8 KTRFHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPpkerymGEPRA 87
Cdd:COG0513 1 MMSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRP------RAPQA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 88 LIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDMVEVMVLDE 167
Cdd:COG0513 75 LILAPTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRG-VDIVVATPGRLLDLIERGALDLSGVETLVLDE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 168 ADRMLDMGFIPQVRQIIRQTPHkgERQTLLFSATFTDDVMNLAKQWTVDPAIVEIEPENVASDTVEQHVYAVAGSDKYKL 247
Cdd:COG0513 154 ADRMLDMGFIEDIERILKLLPK--ERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDKLEL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 248 LYNLVAQNNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHIDGIS 327
Cdd:COG0513 232 LRRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVS 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 308154507 328 HVINFTLPEDPDDYVHRIGRTGRAGASGTSISFAGEDDAFALPPIEELLGRKITC-EMPPAELLKPVPRKH 397
Cdd:COG0513 312 HVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQKIEEeELPGFEPVEEKRLER 382
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
9-395 |
2.00e-143 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 414.37 E-value: 2.00e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 9 TRFHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERYMGEPRAL 88
Cdd:PRK04837 8 QKFSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPAPEDRKVNQPRAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 89 IIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEA 168
Cdd:PRK04837 88 IMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESG-VDILIGTTGRLIDYAKQNHINLGAIQVVVLDEA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 169 DRMLDMGFIPQVRQIIRQTPHKGERQTLLFSATFTDDVMNLAKQWTVDPAIVEIEPENVASDTVEQHVYAVAGSDKYKLL 248
Cdd:PRK04837 167 DRMFDLGFIKDIRWLFRRMPPANQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELFYPSNEEKMRLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 249 YNLVAQNNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHIDGISH 328
Cdd:PRK04837 247 QTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTH 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 308154507 329 VINFTLPEDPDDYVHRIGRTGRAGASGTSISFAGEDDAFALPPIEELLGRKITC-EMPPAELLKPVPR 395
Cdd:PRK04837 327 VFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAIETYIGHSIPVsKYDSDALLTDLPK 394
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
11-395 |
1.19e-122 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 366.58 E-value: 1.19e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERYMGEPRALII 90
Cdd:PRK04537 11 FSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADRKPEDPRALIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 91 APTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQlKQLEARFCDILVATPGRLLDF-NQRGEVHLDMVEVMVLDEAD 169
Cdd:PRK04537 91 APTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQ-RELLQQGVDVIIATPGRLIDYvKQHKVVSLHACEICVLDEAD 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 170 RMLDMGFIPQVRQIIRQTPHKGERQTLLFSATFTDDVMNLAKQWTVDPAIVEIEPENVASDTVEQHVYAVAGSDKYKLLY 249
Cdd:PRK04537 170 RMFDLGFIKDIRFLLRRMPERGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADEEKQTLLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 250 NLVAQNNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHIDGISHV 329
Cdd:PRK04537 250 GLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYV 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 308154507 330 INFTLPEDPDDYVHRIGRTGRAGASGTSISFAGEDDAFALPPIEELLGRKITCEMPPAELLKPVPR 395
Cdd:PRK04537 330 YNYDLPFDAEDYVHRIGRTARLGEEGDAISFACERYAMSLPDIEAYIEQKIPVEPVTAELLTPLPR 395
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
9-386 |
1.72e-113 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 338.46 E-value: 1.72e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 9 TRFHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPppkERYMGEPRAL 88
Cdd:PRK11192 1 TTFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFP---RRKSGPPRIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 89 IIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARFcDILVATPGRLLDFNQRGEVHLDMVEVMVLDEA 168
Cdd:PRK11192 78 ILTPTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQ-DIVVATPGRLLQYIKEENFDCRAVETLILDEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 169 DRMLDMGFIPQVRQIIRQTphKGERQTLLFSAT--------FTDDVMNlakqwtvDPAIVEIEPENVASDTVEQHVY-AV 239
Cdd:PRK11192 157 DRMLDMGFAQDIETIAAET--RWRKQTLLFSATlegdavqdFAERLLN-------DPVEVEAEPSRRERKKIHQWYYrAD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 240 AGSDKYKLLYNLVAQNNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGR 319
Cdd:PRK11192 228 DLEHKTALLCHLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAAR 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 308154507 320 GIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGTSISFAGEDDAFALPPI----EELLGRKITCEMPP 386
Cdd:PRK11192 308 GIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLLLGKIeryiEEPLKARVIDELRP 378
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
11-380 |
6.93e-113 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 337.55 E-value: 6.93e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPP-PKERymgEP-RAL 88
Cdd:PRK10590 3 FDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPhAKGR---RPvRAL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 89 IIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEA 168
Cdd:PRK10590 80 ILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGG-VDVLVATPGRLLDLEHQNAVKLDQVEILVLDEA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 169 DRMLDMGFIPQVRQIIRQTPHKgeRQTLLFSATFTDDVMNLAKQWTVDPAIVEIEPENVASDTVEQHVYAVAGSDKYKLL 248
Cdd:PRK10590 159 DRMLDMGFIHDIRRVLAKLPAK--RQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKRKRELL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 249 YNLVAQNNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHIDGISH 328
Cdd:PRK10590 237 SQMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPH 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 308154507 329 VINFTLPEDPDDYVHRIGRTGRAGASGTSISFAGEDDAFALPPIEELLGRKI 380
Cdd:PRK10590 317 VVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIEKLLKKEI 368
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
9-394 |
2.44e-111 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 333.69 E-value: 2.44e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 9 TRFHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISiitqLLQTPPPKERymgEPRAL 88
Cdd:PRK11776 4 TAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLG----LLQKLDVKRF---RVQAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 89 IIAPTRELVVQIAKDAAALTKYT-GLNVMTFVGGMDFDKQLKQLE--ARfcdILVATPGRLLDFNQRGEVHLDMVEVMVL 165
Cdd:PRK11776 77 VLCPTRELADQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEhgAH---IIVGTPGRILDHLRKGTLDLDALNTLVL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 166 DEADRMLDMGFIPQVRQIIRQTPhkGERQTLLFSATFTDDVMNLAKQWTVDPAIVEIEpENVASDTVEQHVYAVAGSDKY 245
Cdd:PRK11776 154 DEADRMLDMGFQDAIDAIIRQAP--ARRQTLLFSATYPEGIAAISQRFQRDPVEVKVE-STHDLPAIEQRFYEVSPDERL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 246 KLLYNLVAQNNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHIDG 325
Cdd:PRK11776 231 PALQRLLLHHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKA 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 326 ISHVINFTLPEDPDDYVHRIGRTGRAGASGTSISFAGEDDAFALPPIEELLGRKITCE-MPPAELLKPVP 394
Cdd:PRK11776 311 LEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIEDYLGRKLNWEpLPSLSPLSGVP 380
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
20-221 |
1.40e-92 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 276.25 E-value: 1.40e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 20 LMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERymgEPRALIIAPTRELVVQ 99
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKKGR---GPQALVLAPTRELAMQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 100 IAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQ 179
Cdd:cd00268 78 IAEVARKLGKGTGLKVAAIYGGAPIKKQIEALKKG-PDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEED 156
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 308154507 180 VRQIIRQTPHKgeRQTLLFSATFTDDVMNLAKQWTVDPAIVE 221
Cdd:cd00268 157 VEKILSALPKD--RQTLLFSATLPEEVKELAKKFLKNPVRIE 196
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
6-390 |
1.69e-80 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 259.40 E-value: 1.69e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 6 EGKTRFHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTpppkeryMGEP 85
Cdd:PRK11634 3 EFETTFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPE-------LKAP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 86 RALIIAPTRELVVQIAKDAAALTKYT-GLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMV 164
Cdd:PRK11634 76 QILVLAPTRELAVQVAEAMTDFSKHMrGVNVVALYGGQRYDVQLRALR-QGPQIVVGTPGRLLDHLKRGTLDLSKLSGLV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 165 LDEADRMLDMGFIPQVRQIIRQTPhkGERQTLLFSATFTDDVMNLAKQWTVDPAIVEIEPENVASDTVEQHVYAVAGSDK 244
Cdd:PRK11634 155 LDEADEMLRMGFIEDVETIMAQIP--EGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMRK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 245 YKLLYNLVAQNNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHID 324
Cdd:PRK11634 233 NEALVRFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVE 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 308154507 325 GISHVINFTLPEDPDDYVHRIGRTGRAGASGTSISFAGEDDAFALPPIEELLGRKI-TCEMPPAELL 390
Cdd:PRK11634 313 RISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIERTMKLTIpEVELPNAELL 379
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
8-364 |
1.16e-76 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 246.99 E-value: 1.16e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 8 KTRFHDFnlapsLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPppKERYMGEPRA 87
Cdd:PTZ00110 134 YTSFPDY-----ILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINAQP--LLRYGDGPIV 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 88 LIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDE 167
Cdd:PTZ00110 207 LVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALR-RGVEILIACPGRLIDFLESNVTNLRRVTYLVLDE 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 168 ADRMLDMGFIPQVRQIIRQTphKGERQTLLFSATFTDDVMNLAKQwtvdpaIVEIEPENV--------ASDTVEQHVYAV 239
Cdd:PTZ00110 286 ADRMLDMGFEPQIRKIVSQI--RPDRQTLMWSATWPKEVQSLARD------LCKEEPVHVnvgsldltACHNIKQEVFVV 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 240 AGSDKYKLLYNLVAQ--NNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVA 317
Cdd:PTZ00110 358 EEHEKRGKLKMLLQRimRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVA 437
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 308154507 318 GRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGTSISFAGED 364
Cdd:PTZ00110 438 SRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTPD 484
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
11-211 |
9.48e-73 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 226.60 E-value: 9.48e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERYMG---EPRA 87
Cdd:cd17967 2 FEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSVGRGRrkaYPSA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 88 LIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDE 167
Cdd:cd17967 82 LILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLL-RGCDILVATPGRLVDFIERGRISLSSIKFLVLDE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 308154507 168 ADRMLDMGFIPQVRQIIRQT--PHKGERQTLLFSATFTDDVMNLAK 211
Cdd:cd17967 161 ADRMLDMGFEPQIRKIVEHPdmPPKGERQTLMFSATFPREIQRLAA 206
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
16-212 |
7.30e-66 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 208.59 E-value: 7.30e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 16 LAPSLMHAIHDLGFPYCTPIQAQVLGFTLR-GQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERYMgePRALIIAPTR 94
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNTKPAGRRSG--VSALIISPTR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 95 ELVVQIAKDAAALTKY-TGLNVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDF--NQRGEVHLDMVEVMVLDEADRM 171
Cdd:cd17964 79 ELALQIAAEAKKLLQGlRKLRVQSAVGGTSRRAELNRLRRGRPDILVATPGRLIDHleNPGVAKAFTDLDYLVLDEADRL 158
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 308154507 172 LDMGFIPQVRQIIRQTPHKGE--RQTLLFSATFTDDVMNLAKQ 212
Cdd:cd17964 159 LDMGFRPDLEQILRHLPEKNAdpRQTLLFSATVPDEVQQIARL 201
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
11-385 |
3.03e-63 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 208.14 E-value: 3.03e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIitqlLQTPPPKERymgEPRALII 90
Cdd:PTZ00424 30 FDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAA----LQLIDYDLN---ACQALIL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 91 APTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADR 170
Cdd:PTZ00424 103 APTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAG-VHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 171 MLDMGFIPQVRQIIRQTPHkgERQTLLFSATFTDDVMNLAKQWTVDPAIVEIEPENVASDTVEQHvYAVAGSDKYKL--L 248
Cdd:PTZ00424 182 MLSRGFKGQIYDVFKKLPP--DVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQF-YVAVEKEEWKFdtL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 249 YNLVAQNNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHIDGISH 328
Cdd:PTZ00424 259 CDLYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSL 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 308154507 329 VINFTLPEDPDDYVHRIGRTGRAGASGTSISFAGEDDAFALPPIEELLGRKITcEMP 385
Cdd:PTZ00424 339 VINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHYNTQIE-EMP 394
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
11-210 |
7.53e-63 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 202.50 E-value: 7.53e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQT--PPPKERYMGEPRAL 88
Cdd:cd18052 45 FEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEglTASSFSEVQEPQAL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 89 IIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEA 168
Cdd:cd18052 125 IVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIE-KGCHILVATPGRLLDFIGRGKISLSKLKYLILDEA 203
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 308154507 169 DRMLDMGFIPQVRQIIRQ--TPHKGERQTLLFSATFTDDVMNLA 210
Cdd:cd18052 204 DRMLDMGFGPEIRKLVSEpgMPSKEDRQTLMFSATFPEEIQRLA 247
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
20-211 |
1.70e-62 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 199.40 E-value: 1.70e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 20 LMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIItQLLQTPPPKERYMgepRALIIAPTRELVVQ 99
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPIL-ERLLYRPKKKAAT---RVLVLVPTRELAMQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 100 IAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDF--NQRGeVHLDMVEVMVLDEADRMLDMGFI 177
Cdd:cd17947 77 CFSVLQQLAQFTDITFALAVGGLSLKAQEAALRAR-PDIVIATPGRLIDHlrNSPS-FDLDSIEILVLDEADRMLEEGFA 154
|
170 180 190
....*....|....*....|....*....|....
gi 308154507 178 PQVRQIIRQTPHkgERQTLLFSATFTDDVMNLAK 211
Cdd:cd17947 155 DELKEILRLCPR--TRQTMLFSATMTDEVKDLAK 186
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
11-376 |
3.59e-61 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 205.79 E-value: 3.59e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISII---TQLLQTPPPKERymgEPRA 87
Cdd:PLN00206 123 FSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIIsrcCTIRSGHPSEQR---NPLA 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 88 LIIAPTRELVVQIAKDAAALTKytGLNVMT--FVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVL 165
Cdd:PLN00206 200 MVLTPTRELCVQVEDQAKVLGK--GLPFKTalVVGGDAMPQQLYRIQ-QGVELIVGTPGRLIDLLSKHDIELDNVSVLVL 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 166 DEADRMLDMGFIPQVRQIIRQTPhkgERQTLLFSATFTDDVMNLAKQWTVDPAIVEIEPENVASDTVEQHVYAVAGSDKY 245
Cdd:PLN00206 277 DEVDCMLERGFRDQVMQIFQALS---QPQVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKK 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 246 KLLYNLVAQNNWER--VMVFANRKDEVRRIEERLTK-DGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIH 322
Cdd:PLN00206 354 QKLFDILKSKQHFKppAVVFVSSRLGADLLANAITVvTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVD 433
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 308154507 323 IDGISHVINFTLPEDPDDYVHRIGRTGRAGASGTSISFAGEDDAFALPPIEELL 376
Cdd:PLN00206 434 LLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNLFPELVALL 487
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
232-360 |
7.30e-58 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 185.02 E-value: 7.30e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 232 VEQHVYAVAGSDKYKLLY-NLVAQNNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRV 310
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLlLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 308154507 311 LVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGTSISF 360
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITF 130
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
11-221 |
1.03e-56 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 184.83 E-value: 1.03e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKerymgepRALII 90
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRF-------FALVL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 91 APTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLeARFCDILVATPGRLLDF--NQRGeVHLDMVEVMVLDEA 168
Cdd:cd17954 75 APTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIAL-AKKPHVIVATPGRLVDHleNTKG-FSLKSLKFLVMDEA 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 308154507 169 DRMLDMGFIPQVRQIIRQTPHkgERQTLLFSATFTDDVMNLAKQWTVDPAIVE 221
Cdd:cd17954 153 DRLLNMDFEPEIDKILKVIPR--ERTTYLFSATMTTKVAKLQRASLKNPVKIE 203
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
9-211 |
1.21e-56 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 186.01 E-value: 1.21e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 9 TRFHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPK-----ERYMG 83
Cdd:cd18051 21 ETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQGPGEslpseSGYYG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 84 E----PRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDM 159
Cdd:cd18051 101 RrkqyPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLE-RGCHLLVATPGRLVDMLERGKIGLDY 179
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 308154507 160 VEVMVLDEADRMLDMGFIPQVRQIIRQ--TPHKGERQTLLFSATFTDDVMNLAK 211
Cdd:cd18051 180 CKYLVLDEADRMLDMGFEPQIRRIVEQdtMPPTGERQTLMFSATFPKEIQMLAR 233
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
33-209 |
4.56e-56 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 181.67 E-value: 4.56e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 33 TPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPkerymgePRALIIAPTRELVVQIAKDAAALTKYTG 112
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNG-------PQALVLAPTRELAEQIYEELKKLGKGLG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 113 LNVMTFVGGMDFDKQLKQLeaRFCDILVATPGRLLDFNQRgEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPhkGE 192
Cdd:pfam00270 74 LKVASLLGGDSRKEQLEKL--KGPDILVGTPGRLLDLLQE-RKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLP--KK 148
|
170
....*....|....*..
gi 308154507 193 RQTLLFSATFTDDVMNL 209
Cdd:pfam00270 149 RQILLLSATLPRNLEDL 165
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
20-220 |
4.86e-56 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 183.68 E-value: 4.86e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 20 LMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERYMGE-PRALIIAPTRELVV 98
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEETKDDgPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 99 QIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIP 178
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLR-NGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGFEP 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 179 QVRQIIRQTP------------------HKGERQTLLFSATFTDDVMNLAKQWTVDPAIV 220
Cdd:cd17945 160 QVTKILDAMPvsnkkpdteeaeklaasgKHRYRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
20-213 |
1.37e-52 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 175.12 E-value: 1.37e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 20 LMHAIHDLGFPYCTPIQAQVLGFTLR-GQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERYMGE--PRALIIAPTREL 96
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRdGKDVIGAAETGSGKTLAFGIPILERLLSQKSSNGVGGKQkpLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 97 VVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDM---VEVMVLDEADRMLD 173
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKR-PEIVVATPGRLWELIQEGNEHLANlksLRFLVLDEADRMLE 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 308154507 174 MGFIPQVRQIIR-----QTPHKGERQTLLFSATFT-DDVMNLAKQW 213
Cdd:cd17946 160 KGHFAELEKILEllnkdRAGKKRKRQTFVFSATLTlDHQLPLKLNS 205
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
20-211 |
1.96e-52 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 173.53 E-value: 1.96e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 20 LMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERymGEPRALIIAPTRELVVQ 99
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANLKK--GQVGALIISPTRELATQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 100 IAKDAAALTKYTG--LNVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDM--VEVMVLDEADRMLDMG 175
Cdd:cd17960 79 IYEVLQSFLEHHLpkLKCQLLIGGTNVEEDVKKFKRNGPNILVGTPGRLEELLSRKADKVKVksLEVLVLDEADRLLDLG 158
|
170 180 190
....*....|....*....|....*....|....*.
gi 308154507 176 FIPQVRQIIRQTPHkgERQTLLFSATFTDDVMNLAK 211
Cdd:cd17960 159 FEADLNRILSKLPK--QRRTGLFSATQTDAVEELIK 192
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
20-220 |
6.28e-52 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 172.21 E-value: 6.28e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 20 LMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPppkERYMGE-PRALIIAPTRELVV 98
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQR---ELEKGEgPIAVIVAPTRELAQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 99 QIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIP 178
Cdd:cd17952 78 QIYLEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEG-AEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEY 156
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 308154507 179 QVRQIIRQTphKGERQTLLFSATFTDDVMNLAKQWTVDPAIV 220
Cdd:cd17952 157 QVRSIVGHV--RPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
20-220 |
8.47e-52 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 171.78 E-value: 8.47e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 20 LMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKErymGE-PRALIIAPTRELVV 98
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPLER---GDgPIVLVLAPTRELAQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 99 QIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIP 178
Cdd:cd17966 78 QIQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLR-RGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEP 156
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 308154507 179 QVRQIIRQTphKGERQTLLFSATFTDDVMNLAKQWTVDPAIV 220
Cdd:cd17966 157 QIRKIVDQI--RPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
16-222 |
3.38e-51 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 171.02 E-value: 3.38e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 16 LAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKErymGE-PRALIIAPTR 94
Cdd:cd17953 19 LSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPVKP---GEgPIGLIMAPTR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 95 ELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDF---NQRGEVHLDMVEVMVLDEADRM 171
Cdd:cd17953 96 ELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELK-RGAEIVVCTPGRMIDIltaNNGRVTNLRRVTYVVLDEADRM 174
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 308154507 172 LDMGFIPQVRQIIRQTphKGERQTLLFSATFTDDVMNLAKQWTVDPaiVEI 222
Cdd:cd17953 175 FDMGFEPQIMKIVNNI--RPDRQTVLFSATFPRKVEALARKVLHKP--IEI 221
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
11-220 |
1.32e-50 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 169.02 E-value: 1.32e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIItQLLQTPPPKerymGEPRALII 90
Cdd:cd17959 3 FQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMI-EKLKAHSPT----VGARALIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 91 APTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLeARFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADR 170
Cdd:cd17959 78 SPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEAL-ASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADR 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 308154507 171 MLDMGFIPQVRQIIRQTPhkGERQTLLFSATFTDDVMNLAKQWTVDPAIV 220
Cdd:cd17959 157 LFEMGFAEQLHEILSRLP--ENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
20-220 |
1.02e-48 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 163.79 E-value: 1.02e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 20 LMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERYMGePRALIIAPTRELVVQ 99
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPREQRNG-PGVLVLTPTRELALQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 100 IaKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQ 179
Cdd:cd17958 80 I-EAECSKYSYKGLKSVCVYGGGNRNEQIEDLS-KGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQ 157
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 308154507 180 VRQIIRQTphKGERQTLLFSATFTDDVMNLAKQWTVDPAIV 220
Cdd:cd17958 158 IRKILLDI--RPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
20-217 |
2.66e-48 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 162.76 E-value: 2.66e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 20 LMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQtpPPKErymGEPRALIIAPTRELVVQ 99
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGK--PRKK---KGLRALILAPTRELASQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 100 IAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQ 179
Cdd:cd17957 76 IYRELLKLSKGTGLRIVLLSKSLEAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQ 155
|
170 180 190
....*....|....*....|....*....|....*...
gi 308154507 180 VRQIIRQTPHKgERQTLLFSATFTDDVMNLAKQWTVDP 217
Cdd:cd17957 156 TDEILAACTNP-NLQRSLFSATIPSEVEELARSVMKDP 192
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
11-217 |
9.30e-48 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 161.62 E-value: 9.30e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLlqtpppkeryMGEPR---A 87
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL----------SEDPYgifA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 88 LIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDF---NQRGEVHLDMVEVMV 164
Cdd:cd17955 71 LVLTPTRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKR-PHIVVATPGRLADHlrsSDDTTKVLSRVKFLV 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 308154507 165 LDEADRMLDMGFIPQVRQIIRQTPHKgeRQTLLFSATFTDDVMNLAKQWTVDP 217
Cdd:cd17955 150 LDEADRLLTGSFEDDLATILSALPPK--RQTLLFSATLTDALKALKELFGNKP 200
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
24-235 |
9.42e-48 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 161.51 E-value: 9.42e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 24 IHDLGFPYCTPIQAQVLGFTLRG-QDAIGRAQTGTGKTAAFLISIITQLLQTPPPkerymgepRALIIAPTRELVVQIAK 102
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKGG--------RVLVLVPTRELAEQWAE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 103 DAAALTKYTGLNVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQ 182
Cdd:smart00487 73 ELKKLGPSLGLKVVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEK 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 308154507 183 IIRQTPHKgeRQTLLFSATFTDDVMNLAKQwtVDPAIVEIEPENVASDTVEQH 235
Cdd:smart00487 153 LLKLLPKN--VQLLLLSATPPEEIENLLEL--FLNDPVFIDVGFTPLEPIEQF 201
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
11-222 |
1.29e-47 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 160.93 E-value: 1.29e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLlqtpPPKERYMgepRALII 90
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKI----DPKKDVI---QALIL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 91 APTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARFcDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADR 170
Cdd:cd17940 74 VPTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTV-HVLVGTPGRILDLAKKGVADLSHCKTLVLDEADK 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 308154507 171 MLDMGFIPQVRQIIRQTPHkgERQTLLFSATFTDDVMNLAKQWTVDPaiVEI 222
Cdd:cd17940 153 LLSQDFQPIIEKILNFLPK--ERQILLFSATFPLTVKNFMDRHMHNP--YEI 200
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
28-211 |
3.21e-46 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 157.45 E-value: 3.21e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 28 GFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLqtpppKERYMGEP--RALIIAPTRELVVQIAKDAA 105
Cdd:cd17941 9 GFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLY-----RERWTPEDglGALIISPTRELAMQIFEVLR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 106 ALTKYTGLNVMTFVGGMDFDKQLKQLEArfCDILVATPGRLLD-FNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQII 184
Cdd:cd17941 84 KVGKYHSFSAGLIIGGKDVKEEKERINR--MNILVCTPGRLLQhMDETPGFDTSNLQMLVLDEADRILDMGFKETLDAIV 161
|
170 180
....*....|....*....|....*..
gi 308154507 185 RQTPhkGERQTLLFSATFTDDVMNLAK 211
Cdd:cd17941 162 ENLP--KSRQTLLFSATQTKSVKDLAR 186
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
10-216 |
3.40e-44 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 153.24 E-value: 3.40e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 10 RFHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLlQTPPPKERYMGePRALI 89
Cdd:cd18049 25 NFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHI-NHQPFLERGDG-PICLV 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 90 IAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEAD 169
Cdd:cd18049 103 LAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLE-RGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEAD 181
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 308154507 170 RMLDMGFIPQVRQIIRQTphKGERQTLLFSATFTDDVMNLAKQWTVD 216
Cdd:cd18049 182 RMLDMGFEPQIRKIVDQI--RPDRQTLMWSATWPKEVRQLAEDFLKD 226
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
9-222 |
4.89e-43 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 149.42 E-value: 4.89e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 9 TRFHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLlqTPPPkerymGEPRAL 88
Cdd:cd17950 2 SGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQL--EPVD-----GQVSVL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 89 IIAPTRELVVQIAKDAAALTKY-TGLNVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDE 167
Cdd:cd17950 75 VICHTRELAFQISNEYERFSKYmPNVKTAVFFGGVPIKKDIEVLKNKCPHIVVGTPGRILALVREKKLKLSHVKHFVLDE 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 308154507 168 ADRM---LDMGfiPQVRQIIRQTPHkgERQTLLFSATFTDDVMNLAKQWTVDPAIVEI 222
Cdd:cd17950 155 CDKMleqLDMR--RDVQEIFRATPH--DKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
11-217 |
2.96e-42 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 147.21 E-value: 2.96e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLlqtpppkERYMGEPRALII 90
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQI-------DTSLKATQALVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 91 APTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADR 170
Cdd:cd18046 74 APTRELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAG-PHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADE 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 308154507 171 MLDMGFIPQVRQIIRQTPHkgERQTLLFSATFTDDVMNLAKQWTVDP 217
Cdd:cd18046 153 MLSRGFKDQIYDIFQKLPP--DTQVVLLSATMPNDVLEVTTKFMRDP 197
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
16-220 |
7.33e-42 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 146.19 E-value: 7.33e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 16 LAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERYMGePRALIIAPTRE 95
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESGEEQG-TRALILVPTRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 96 LVVQIAKDAAALTKYTG--LNVMTFVGGMDfDKQLKQLEARFCDILVATPGRLLDFNQRG-EVHLDMVEVMVLDEADRML 172
Cdd:cd17961 80 LAQQVSKVLEQLTAYCRkdVRVVNLSASSS-DSVQRALLAEKPDIVVSTPARLLSHLESGsLLLLSTLKYLVIDEADLVL 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 308154507 173 DMGFIPQVRQIIRQTPhkGERQTLLFSATFTDDVMNLAKQWTVDPAIV 220
Cdd:cd17961 159 SYGYEEDLKSLLSYLP--KNYQTFLMSATLSEDVEALKKLVLHNPAIL 204
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
9-216 |
1.37e-41 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 147.46 E-value: 1.37e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 9 TRFHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLlQTPPPKERYMGePRAL 88
Cdd:cd18050 62 FAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHI-NHQPYLERGDG-PICL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 89 IIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEA 168
Cdd:cd18050 140 VLAPTRELAQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLE-RGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEA 218
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 308154507 169 DRMLDMGFIPQVRQIIRQTphKGERQTLLFSATFTDDVMNLAKQWTVD 216
Cdd:cd18050 219 DRMLDMGFEPQIRKIVDQI--RPDRQTLMWSATWPKEVRQLAEDFLRD 264
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
28-213 |
9.21e-41 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 143.06 E-value: 9.21e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 28 GFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERYMGePRALIIAPTRELVVQIAKDAAAL 107
Cdd:cd17944 9 GVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRGRA-PKVLVLAPTRELANQVTKDFKDI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 108 TKytGLNVMTFVGGMDFDKQLKQLEARFcDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQT 187
Cdd:cd17944 88 TR--KLSVACFYGGTPYQQQIFAIRNGI-DILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVEEILSVS 164
|
170 180
....*....|....*....|....*....
gi 308154507 188 PHKGER---QTLLFSATFTDDVMNLAKQW 213
Cdd:cd17944 165 YKKDSEdnpQTLLFSATCPDWVYNVAKKY 193
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
16-212 |
4.10e-40 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 141.17 E-value: 4.10e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 16 LAPSLMHAIHDLGFPYCTPIQAQVLGFTLRG--QDAIGRAQTGTGKTAAFLISIITQLlqtpPPKERYmgePRALIIAPT 93
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRV----DPTLKS---PQALCLAPT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 94 RELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQlKQLEARfcdILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLD 173
Cdd:cd17963 74 RELARQIGEVVEKMGKFTGVKVALAVPGNDVPRG-KKITAQ---IVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLD 149
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 308154507 174 M-GFIPQVRQIIRQTPHKgeRQTLLFSATFTDDVMNLAKQ 212
Cdd:cd17963 150 TqGHGDQSIRIKRMLPRN--CQILLFSATFPDSVRKFAEK 187
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
33-220 |
7.83e-40 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 140.94 E-value: 7.83e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 33 TPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLL--QTPPPKERYMGePRALIIAPTRELVVQ----IAKDAAA 106
Cdd:cd17951 14 TPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALeqEKKLPFIKGEG-PYGLIVCPSRELARQthevIEYYCKA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 107 LTK--YTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQII 184
Cdd:cd17951 93 LQEggYPQLRCLLCIGGMSVKEQLEVIR-KGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMIDMGFEEDIRTIF 171
|
170 180 190
....*....|....*....|....*....|....*.
gi 308154507 185 RQtpHKGERQTLLFSATFTDDVMNLAKQWTVDPAIV 220
Cdd:cd17951 172 SY--FKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
33-217 |
5.56e-38 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 136.18 E-value: 5.56e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 33 TPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERYMGePRALIIAPTRELVVQIAKDAAALTK-YT 111
Cdd:cd17949 15 TAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDRSDG-TLALVLVPTRELALQIYEVLEKLLKpFH 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 112 GLNVMTFVGGMDFDKQlkqlEARF---CDILVATPGRLLDfnqrgevHLDMVEV--------MVLDEADRMLDMGFIPQV 180
Cdd:cd17949 94 WIVPGYLIGGEKRKSE----KARLrkgVNILIATPGRLLD-------HLKNTQSfdvsnlrwLVLDEADRLLDMGFEKDI 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 308154507 181 RQIIR-----------QTPHKGERQTLLFSATFTDDVMNLAKQWTVDP 217
Cdd:cd17949 163 TKILEllddkrskaggEKSKPSRRQTVLVSATLTDGVKRLAGLSLKDP 210
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
13-222 |
6.30e-38 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 135.53 E-value: 6.30e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 13 DFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPpkerymgEPRALIIAP 92
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVR-------ETQALVLAP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 93 TRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRML 172
Cdd:cd17939 74 TRELAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYG-PHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEML 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 308154507 173 DMGFIPQVRQIIRQTPhkGERQTLLFSATFTDDVMNLAKQWTVDPaiVEI 222
Cdd:cd17939 153 SRGFKDQIYDIFQFLP--PETQVVLFSATMPHEVLEVTKKFMRDP--VRI 198
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
20-220 |
1.52e-37 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 134.60 E-value: 1.52e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 20 LMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQtpppkerYMGEPRALIIAPTRELVVQ 99
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLT-------EHRNPSALILTPTRELAVQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 100 IAKDAAALTKytGLNVMT---FVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGF 176
Cdd:cd17962 74 IEDQAKELMK--GLPPMKtalLVGGLPLPPQLYRLQ-QGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGF 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 308154507 177 IPQVRQIIRQTPHkgERQTLLFSATFTDDVMNLAKQWTVDPAIV 220
Cdd:cd17962 151 QQQVLDILENISH--DHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
11-221 |
3.06e-37 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 133.99 E-value: 3.06e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIItQLLQtpppkerymgeprALII 90
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVL-QIVV-------------ALIL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 91 APTRELVVQIAKDAAALTKYT---GLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDMVEVMVLDE 167
Cdd:cd17938 67 EPSRELAEQTYNCIENFKKYLdnpKLRVALLIGGVKAREQLKRLESG-VDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDE 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 308154507 168 ADRMLDMGFIPQVRQIIRQTPHKGER----QTLLFSATF-TDDVMNLAKQWTVDPAIVE 221
Cdd:cd17938 146 ADRLLSQGNLETINRIYNRIPKITSDgkrlQVIVCSATLhSFEVKKLADKIMHFPTWVD 204
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
21-211 |
2.40e-36 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 131.33 E-value: 2.40e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 21 MHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLqtpppKERYMgePR----ALIIAPTREL 96
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLY-----KLKFK--PRngtgVIIISPTREL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 97 VVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARFCdILVATPGRLLDF--NQRGEVHLDMvEVMVLDEADRMLDM 174
Cdd:cd17942 75 ALQIYGVAKELLKYHSQTFGIVIGGANRKAEAEKLGKGVN-ILVATPGRLLDHlqNTKGFLYKNL-QCLIIDEADRILEI 152
|
170 180 190
....*....|....*....|....*....|....*..
gi 308154507 175 GFIPQVRQIIRQTPHkgERQTLLFSATFTDDVMNLAK 211
Cdd:cd17942 153 GFEEEMRQIIKLLPK--RRQTMLFSATQTRKVEDLAR 187
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
11-217 |
2.09e-35 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 129.12 E-value: 2.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIitqlLQTPPPKERymgEPRALII 90
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISV----LQCLDIQVR---ETQALIL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 91 APTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADR 170
Cdd:cd18045 74 SPTRELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYG-QHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADE 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 308154507 171 MLDMGFIPQVRQIIRQTPHKgeRQTLLFSATFTDDVMNLAKQWTVDP 217
Cdd:cd18045 153 MLNKGFKEQIYDVYRYLPPA--TQVVLVSATLPQDILEMTNKFMTDP 197
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
243-352 |
6.50e-35 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 124.63 E-value: 6.50e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 243 DKYKLLYNLVAQNNWERVMVFANRKDEVRrIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIH 322
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100 110
....*....|....*....|....*....|
gi 308154507 323 IDGISHVINFTLPEDPDDYVHRIGRTGRAG 352
Cdd:pfam00271 80 LPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
20-202 |
2.63e-33 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 124.40 E-value: 2.63e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 20 LMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERYMGEPRALIIAPTRELVVQ 99
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGPFNAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 100 IAKDAAALTKYTGLNVMTFVGGmdfdkQLKQ--LEARF--CDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMG 175
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKVITGG-----RTKRqiRNPHFeeVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDS 155
|
170 180 190
....*....|....*....|....*....|....*...
gi 308154507 176 FIPQVRQIIRQTPHKGER-----------QTLLFSATF 202
Cdd:cd17948 156 FNEKLSHFLRRFPLASRRsentdgldpgtQLVLVSATM 193
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
20-221 |
4.30e-33 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 122.37 E-value: 4.30e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 20 LMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLqtpppkeRYMGEPRALIIAPTRELVVQ 99
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLD-------LERRHPQVLILAPTREIAVQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 100 IAKDAAALTKY-TGLNVMTFVGGMDFDKQLKQLeaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIP 178
Cdd:cd17943 74 IHDVFKKIGKKlEGLKCEVFIGGTPVKEDKKKL--KGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQK 151
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 308154507 179 QVRQIIRQTPHKgeRQTLLFSATFTDDVMNLAKQWTVDPAIVE 221
Cdd:cd17943 152 DVNWIFSSLPKN--KQVIAFSATYPKNLDNLLARYMRKPVLVR 192
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
34-210 |
6.99e-31 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 117.73 E-value: 6.99e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 34 PIQAQVLGFTLRGQ--DAIGR-------AQTGTGKTAAFLISIITQLLQTPPPKerymgePRALIIAPTRELVVQIAKDA 104
Cdd:cd17956 15 PVQAAVIPWLLPSSksTPPYRpgdlcvsAPTGSGKTLAYVLPIVQALSKRVVPR------LRALIVVPTKELVQQVYKVF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 105 AALTKYTGLNVMTFVGGMDFDKQLKQLEARFC-------DILVATPGRLLDfnqrgevHLDM--------VEVMVLDEAD 169
Cdd:cd17956 89 ESLCKGTGLKVVSLSGQKSFKKEQKLLLVDTSgrylsrvDILVATPGRLVD-------HLNStpgftlkhLRFLVIDEAD 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 308154507 170 RMLDMGF------------------IPQVRQIIRQTPHKGERQTLLFSATFTDDVMNLA 210
Cdd:cd17956 162 RLLNQSFqdwletvmkalgrptapdLGSFGDANLLERSVRPLQKLLFSATLTRDPEKLS 220
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
271-352 |
3.66e-28 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 105.76 E-value: 3.66e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 271 RRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGR 350
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 308154507 351 AG 352
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
11-227 |
3.62e-26 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 105.10 E-value: 3.62e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRG--QDAIGRAQTGTGKTAAFLISIITQLlqtpPPKERYmgePRAL 88
Cdd:cd18048 20 FEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRV----DALKLY---PQCL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 89 IIAPTRELVVQIAKDAAALTKY-TGLNVMTFVGGMDFDKQlKQLEARfcdILVATPGRLLD--FNQRgEVHLDMVEVMVL 165
Cdd:cd18048 93 CLSPTFELALQTGKVVEEMGKFcVGIQVIYAIRGNRPGKG-TDIEAQ---IVIGTPGTVLDwcFKLR-LIDVTNISVFVL 167
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308154507 166 DEADRMLDM-GFIPQVRQIIRQTPHkgERQTLLFSATFTDDVMNLAKQWTVDPAIVEIEPENV 227
Cdd:cd18048 168 DEADVMINVqGHSDHSVRVKRSMPK--ECQMLLFSATFEDSVWAFAERIVPDPNIIKLKKEEL 228
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
55-347 |
9.02e-20 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 91.24 E-value: 9.02e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 55 TGTGKT--AAFLIsiitqllqtpppkERYMGEPRALIIAPTRELVVQIAKDAAALtkytgLNVMTFVGGMDFDKqlkqle 132
Cdd:COG1061 109 TGTGKTvlALALA-------------AELLRGKRVLVLVPRRELLEQWAEELRRF-----LGDPLAGGGKKDSD------ 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 133 arfCDILVATP---GRLLDFNQRGEvHLDMVevmVLDEADRMLDMGFipqvRQIIRQTPHKgerQTLLFSAT--FTDDVM 207
Cdd:COG1061 165 ---APITVATYqslARRAHLDELGD-RFGLV---IIDEAHHAGAPSY----RRILEAFPAA---YRLGLTATpfRSDGRE 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 208 N-----------------LAKQWTVDPAIVEI----EPENVASDTVEQHV-YAVAGSDKYKL--LYNLVAQN-NWERVMV 262
Cdd:COG1061 231 IllflfdgivyeyslkeaIEDGYLAPPEYYGIrvdlTDERAEYDALSERLrEALAADAERKDkiLRELLREHpDDRKTLV 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 263 FANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYV 342
Cdd:COG1061 311 FCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFI 390
|
....*
gi 308154507 343 HRIGR 347
Cdd:COG1061 391 QRLGR 395
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
53-201 |
1.10e-19 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 87.43 E-value: 1.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 53 AQTGTGKTAAFLISIITQL--------LQTPPPKE--RYMGEPRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGM 122
Cdd:cd17965 68 AETGSGKTLAYLAPLLDYLkrqeqepfEEAEEEYEsaKDTGRPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGF 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 123 DFDKQLKQLEARF-CDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPHKgeRQTLLFSAT 201
Cdd:cd17965 148 GPSYQRLQLAFKGrIDILVTTPGKLASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKL--KHLILCSAT 225
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
11-221 |
2.09e-19 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 85.54 E-value: 2.09e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 11 FHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRG--QDAIGRAQTGTGKTAAFLISIITQLlqtpPPKERYmgePRAL 88
Cdd:cd18047 3 FEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQV----EPANKY---PQCL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 89 IIAPTRELVVQIAKDAAALTK-YTGLNVMTFVGGMDFDKQLKQLEarfcDILVATPGRLLDFNQRGE-VHLDMVEVMVLD 166
Cdd:cd18047 76 CLSPTYELALQTGKVIEQMGKfYPELKLAYAVRGNKLERGQKISE----QIVIGTPGTVLDWCSKLKfIDPKKIKVFVLD 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 308154507 167 EADRML-DMGFIPQVRQIIRQTPhKGeRQTLLFSATFTDDVMNLAKQWTVDPAIVE 221
Cdd:cd18047 152 EADVMIaTQGHQDQSIRIQRMLP-RN-CQMLLFSATFEDSVWKFAQKVVPDPNVIK 205
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
244-353 |
9.82e-14 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 72.84 E-value: 9.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 244 KYKLLYNLVAQ----NNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGD--------VPQHKRIRTLEGFREGKIRVL 311
Cdd:COG1111 336 KLSKLREILKEqlgtNPDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGQaskegdkgLTQKEQIEILERFRAGEFNVL 415
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 308154507 312 VATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGA 353
Cdd:COG1111 416 VATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKRE 457
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
55-168 |
2.31e-13 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 68.45 E-value: 2.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 55 TGTGKTaafLISI--ITQLLQTPPPKERymGEPRALIIAPTRELVVQIAKdaaALTKYTGLNVMTFVGGMDFDKQ----L 128
Cdd:cd18034 25 TGSGKT---LIAVmlIKEMGELNRKEKN--PKKRAVFLVPTVPLVAQQAE---AIRSHTDLKVGEYSGEMGVDKWtkerW 96
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 308154507 129 KQLEARFcDILVATPGRLLDFNQRGEVHLDMVEVMVLDEA 168
Cdd:cd18034 97 KEELEKY-DVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
46-201 |
2.42e-13 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 67.04 E-value: 2.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 46 GQDAIGRAQTGTGKTAAFLISIITQLLQTpppkerymgEPRALIIAPTRELVVQIAKDAAALTKYtGLNVMTFVGGMDfD 125
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLLKK---------GKKVLVLVPTKALALQTAERLRELFGP-GIRVAVLVGGSS-A 69
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 308154507 126 KQLKQLEARFCDILVATPGRLL-DFNQRGEVHLDMVEVMVLDEADRML-DMGFIPQVRQIIRQTpHKGERQTLLFSAT 201
Cdd:cd00046 70 EEREKNKLGDADIIIATPDMLLnLLLREDRLFLKDLKLIIVDEAHALLiDSRGALILDLAVRKA-GLKNAQVILLSAT 146
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
244-353 |
8.34e-12 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 66.82 E-value: 8.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 244 KYKLLYNLVAQ----NNWERVMVFANRKDEVRRIEERLTKDGISAA----QMSGD----VPQHKRIRTLEGFREGKIRVL 311
Cdd:PRK13766 348 KLEKLREIVKEqlgkNPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVrfvgQASKDgdkgMSQKEQIEILDKFRAGEFNVL 427
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 308154507 312 VATDVAGRGIHIdgishvinftlPEdpDDYV-------------HRIGRTGRAGA 353
Cdd:PRK13766 428 VSTSVAEEGLDI-----------PS--VDLVifyepvpseirsiQRKGRTGRQEE 469
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
246-346 |
1.18e-10 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 59.03 E-value: 1.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 246 KLLYNLVAQNnwERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGK--IRVLVATDVAGRGIHI 323
Cdd:cd18793 18 ELLEELREPG--EKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPdiRVFLLSTKAGGVGLNL 95
|
90 100
....*....|....*....|....*....
gi 308154507 324 DGISHVINFTLPEDPD------DYVHRIG 346
Cdd:cd18793 96 TAANRVILYDPWWNPAveeqaiDRAHRIG 124
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
258-350 |
4.72e-10 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 57.37 E-value: 4.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 258 ERVMVFANRKDEVRRIEERLTKD----------GISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHIDGIS 327
Cdd:cd18801 31 TRVIIFSEFRDSAEEIVNFLSKIrpgiratrfiGQASGKSSKGMSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVD 110
|
90 100
....*....|....*....|...
gi 308154507 328 HVINFTLPEDPDDYVHRIGRTGR 350
Cdd:cd18801 111 LIICYDASPSPIRMIQRMGRTGR 133
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
237-365 |
5.18e-10 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 60.92 E-value: 5.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 237 YAV---AGSDKYKLLYNLVAQNNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVA 313
Cdd:COG0514 207 LEVvpkPPDDKLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVA 286
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 308154507 314 TdVA-GRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGTSISFAGEDD 365
Cdd:COG0514 287 T-IAfGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPED 338
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
262-352 |
7.48e-10 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 56.45 E-value: 7.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 262 VFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDY 341
Cdd:cd18794 35 IYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESY 114
|
90
....*....|.
gi 308154507 342 VHRIGRTGRAG 352
Cdd:cd18794 115 YQESGRAGRDG 125
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
246-348 |
9.30e-10 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 60.24 E-value: 9.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 246 KLLYNLVAQNnwERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGK--IRVLVATDVAGRGIHI 323
Cdd:COG0553 540 ELLEELLAEG--EKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPeaPVFLISLKAGGEGLNL 617
|
90 100 110
....*....|....*....|....*....|.
gi 308154507 324 DGISHVINFTLPEDPD------DYVHRIGRT 348
Cdd:COG0553 618 TAADHVIHYDLWWNPAveeqaiDRAHRIGQT 648
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
244-323 |
2.52e-09 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 55.72 E-value: 2.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 244 KYKLLYNLVAQN-NWERVMVFANRKDEVRRIEERLTKDGISaaqmsGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIH 322
Cdd:cd18789 35 KLRALEELLKRHeQGDKIIVFTDNVEALYRYAKRLLKPFIT-----GETPQSEREEILQNFREGEYNTLVVSKVGDEGID 109
|
.
gi 308154507 323 I 323
Cdd:cd18789 110 L 110
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
259-354 |
7.50e-09 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 54.13 E-value: 7.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 259 RVMVFANRKDEVRRIEERL-----TKDGISAAQMSG----------DVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHI 323
Cdd:cd18802 27 RGIIFVERRATAVVLSRLLkehpsTLAFIRCGFLIGrgnssqrkrsLMTQRKQKETLDKFRDGELNLLIATSVLEEGIDV 106
|
90 100 110
....*....|....*....|....*....|.
gi 308154507 324 DGISHVINFTLPEDPDDYVHRIGRtGRAGAS 354
Cdd:cd18802 107 PACNLVIRFDLPKTLRSYIQSRGR-ARAPNS 136
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
259-352 |
1.17e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 51.55 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 259 RVMVFANRKDEVRRIEERLTkdgisaaqmsgdvpqhkrirtlegfregkirVLVATDVAGRGIHIDGISHVINFTLPEDP 338
Cdd:cd18785 5 KIIVFTNSIEHAEEIASSLE-------------------------------ILVATNVLGEGIDVPSLDTVIFFDPPSSA 53
|
90
....*....|....
gi 308154507 339 DDYVHRIGRTGRAG 352
Cdd:cd18785 54 ASYIQRVGRAGRGG 67
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
33-168 |
1.87e-08 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 53.80 E-value: 1.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 33 TPIQAQVL-GFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQtpppkerymGEPRALIIAPTRELVVQIAKDAAALTKYT 111
Cdd:cd17921 3 NPIQREALrALYLSGDSVLVSAPTSSGKTLIAELAILRALAT---------SGGKAVYIAPTRALVNQKEADLRERFGPL 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 308154507 112 GLNVmtfvGGMDFDKQLKQLEARFCDILVATP----GRLLDFNQRGEVHLDMVevmVLDEA 168
Cdd:cd17921 74 GKNV----GLLTGDPSVNKLLLAEADILVATPekldLLLRNGGERLIQDVRLV---VVDEA 127
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
31-143 |
1.88e-06 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 48.12 E-value: 1.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 31 YCTPIQAQVLGFTLRGQDA-IGRAQTGTGKTAAFLISIItQLLQTPPPKERymGEPRALIIAPTRELVVQIAKDAAALTK 109
Cdd:cd18023 1 YFNRIQSEVFPDLLYSDKNfVVSAPTGSGKTVLFELAIL-RLLKERNPLPW--GNRKVVYIAPIKALCSEKYDDWKEKFG 77
|
90 100 110
....*....|....*....|....*....|....*
gi 308154507 110 YTGLNVMTFVGgmdfDKQLKQL-EARFCDILVATP 143
Cdd:cd18023 78 PLGLSCAELTG----DTEMDDTfEIQDADIILTTP 108
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
261-352 |
1.91e-06 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 49.71 E-value: 1.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 261 MVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDD 340
Cdd:PRK11057 240 IIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIES 319
|
90
....*....|..
gi 308154507 341 YVHRIGRTGRAG 352
Cdd:PRK11057 320 YYQETGRAGRDG 331
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
2-380 |
4.89e-06 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 48.68 E-value: 4.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 2 VEPQEGKTRFHDFNLAPSLMHAIHDLGF--PYctPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPppke 79
Cdd:COG1205 27 IPAREARYAPWPDWLPPELRAALKKRGIerLY--SHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDP---- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 80 rymgEPRALIIAPTRELvvqiAKD-AAALTKYT-----GLNVMTFVGgmDFDKQLKQlEAR-FCDILVATPgrllDFnqr 152
Cdd:COG1205 101 ----GATALYLYPTKAL----ARDqLRRLRELAealglGVRVATYDG--DTPPEERR-WIReHPDIVLTNP----DM--- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 153 geVHLDM-------------VEVMVLDEA---------------DRMldmgfipqvRQIIRQtpHKGERQTLLFSATftd 204
Cdd:COG1205 163 --LHYGLlphhtrwarffrnLRYVVIDEAhtyrgvfgshvanvlRRL---------RRICRH--YGSDPQFILASAT--- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 205 dVMN---LAKQWT-VDPAIVE-------------IEPEnVASDTVEQHVYAVAGsdkyKLLYNLVAQNnwERVMVFANRk 267
Cdd:COG1205 227 -IGNpaeHAERLTgRPVTVVDedgsprgertfvlWNPP-LVDDGIRRSALAEAA----RLLADLVREG--LRTLVFTRS- 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 268 devRRIEERLTKDGISAAQMSGDVPQ----------HKRIRTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPED 337
Cdd:COG1205 298 ---RRGAELLARYARRALREPDLADRvaayragylpEERREIERGLRSGELLGVVSTNALELGIDIGGLDAVVLAGYPGT 374
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 308154507 338 PDDYVHRIGRTGRAGASGTSISFAGED--DAFALPPIEELLGRKI 380
Cdd:COG1205 375 RASFWQQAGRAGRRGQDSLVVLVAGDDplDQYYVRHPEELFERPP 419
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
36-168 |
1.55e-05 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 45.27 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 36 QAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPppkerymgEPRALIIAPTRELvvqiAKD-AAALTKYT--- 111
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDP--------GSRALYLYPTKAL----AQDqLRSLRELLeql 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 308154507 112 --GLNVMTFVGgmDFDKQLKQLEAR-FCDILVATPGRL----LDFNQRGEVHLDMVEVMVLDEA 168
Cdd:cd17923 73 glGIRVATYDG--DTPREERRAIIRnPPRILLTNPDMLhyalLPHHDRWARFLRNLRYVVLDEA 134
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
55-352 |
2.66e-05 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 46.04 E-value: 2.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 55 TGTGKTAAFLISIITQLLQtpppkerymgEPRALIIAPTRELVVQIAKD-AAALTKYtGLNVMTFVGGMDFDKQlkqlEA 133
Cdd:COG1204 47 TASGKTLIAELAILKALLN----------GGKALYIVPLRALASEKYREfKRDFEEL-GIKVGVSTGDYDSDDE----WL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 134 RFCDILVATPGR---LLDFNQRGEVHLDMV---EVMVLDEADRmldmGFIPQV-----RQIIRQTphkgerQTLLFSATf 202
Cdd:COG1204 112 GRYDILVATPEKldsLLRNGPSWLRDVDLVvvdEAHLIDDESR----GPTLEVllarlRRLNPEA------QIVALSAT- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 203 TDDVMNLAkQWtvdpaiveIEPENVASD--TVEQHV-------------YAVAGSDKYKLLYNLVAQNnwERVMVFANRK 267
Cdd:COG1204 181 IGNAEEIA-EW--------LDAELVKSDwrPVPLNEgvlydgvlrfddgSRRSKDPTLALALDLLEEG--GQVLVFVSSR 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 268 ------------------------------DEVRRIEE---------RLTKDGISA--AQMSgdvpqhKRIRTL--EGFR 304
Cdd:COG1204 250 rdaeslakkladelkrrltpeereeleelaEELLEVSEethtneklaDCLEKGVAFhhAGLP------SELRRLveDAFR 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 305 EGKIRVLVATD--VAG----------RGIHIDGIShvinftlPEDPDDYVHRIGRTGRAG 352
Cdd:COG1204 324 EGLIKVLVATPtlAAGvnlparrviiRDTKRGGMV-------PIPVLEFKQMAGRAGRPG 376
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
29-168 |
4.48e-04 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 41.09 E-value: 4.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 29 FPYCTPIQAQVLGFTLRGQDA--IGrAQTGTGKTAAFLISIITQLLQTPppkerymgEPRALIIAPTRELVVQIAKD-AA 105
Cdd:cd18021 1 FKFFNPIQTQVFNSLYNTDDNvfVG-APTGSGKTVCAELALLRHWRQNP--------KGRAVYIAPMQELVDARYKDwRA 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 308154507 106 ALTKYTGLNVMTFVGGMDFDkqLKQLEArfCDILVATPGRlLDF-----NQRGevHLDMVEVMVLDEA 168
Cdd:cd18021 72 KFGPLLGKKVVKLTGETSTD--LKLLAK--SDVILATPEQ-WDVlsrrwKQRK--NVQSVELFIADEL 132
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
55-202 |
5.72e-04 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 39.98 E-value: 5.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 55 TGTGKTAaFLISIItqllqtpppkeRYMGEPRALIIAPTRELVVQIakdAAALTKYTGLNVMTFVGGMDFDKQLKqlear 134
Cdd:cd17926 27 TGSGKTL-TALALI-----------AYLKELRTLIVVPTDALLDQW---KERFEDFLGDSSIGLIGGGKKKDFDD----- 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 135 fCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRmldmgfIP--QVRQIIrqtPHKGERQTLLFSATF 202
Cdd:cd17926 87 -ANVVVATYQSLSNLAEEEKDLFDQFGLLIVDEAHH------LPakTFSEIL---KELNAKYRLGLTATP 146
|
|
| SF2_C_reverse_gyrase |
cd18798 |
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological ... |
267-379 |
1.68e-03 |
|
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350185 [Multi-domain] Cd Length: 174 Bit Score: 39.21 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 267 KDEVRRIEERLTKDGISAAQMSGdvpqhKRIRTLEGFREGKIRVLVAT----DVAGRGI---HIdgISHVINFTLPedPD 339
Cdd:cd18798 37 KEYAEELKEFLERHGIKAELALS-----STEKNLEKFEEGEIDVLIGVasyyGVLVRGIdlpER--IKYAIFYGVP--VT 107
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 308154507 340 DYVHRIGRTGR--AGASGTSISFAGEDDafalPPIEELLGRK 379
Cdd:cd18798 108 TYIQASGRTSRlyAGGLTKGLSVVLVDD----PELFEALKKR 145
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
55-202 |
2.08e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 38.42 E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 55 TGTGKT--AAFLISIITQLLqtpppkerymGEPRALIIAPTRELVVQIAKDaaaLTKYTG--LNVMTFVGGMDFDKQLKQ 130
Cdd:pfam04851 32 TGSGKTltAAKLIARLFKKG----------PIKKVLFLVPRKDLLEQALEE---FKKFLPnyVEIGEIISGDKKDESVDD 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 308154507 131 learfCDILVATPGRLLDFNQRGEVHL--DMVEVMVLDEADRmldmGFIPQVRQIIRQTPHKgerqTLL-FSATF 202
Cdd:pfam04851 99 -----NKIVVTTIQSLYKALELASLELlpDFFDVIIIDEAHR----SGASSYRNILEYFKPA----FLLgLTATP 160
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
31-143 |
3.01e-03 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 38.51 E-value: 3.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 31 YCTPIQAQVLgFTLRGQDA---IGrAQTGTGKTAAFLISIITQLLQTPPPKERYmgepraliIAPTRELVVQIAKD-AAA 106
Cdd:cd18022 1 HFNPIQTQVF-HTLYHTDNnvlLG-APTGSGKTIAAELAMFRAFNKYPGSKVVY--------IAPLKALVRERVDDwKKR 70
|
90 100 110
....*....|....*....|....*....|....*..
gi 308154507 107 LTKYTGLNVMTFVGgmDFDKQLKQLEArfCDILVATP 143
Cdd:cd18022 71 FEEKLGKKVVELTG--DVTPDMKALAD--ADIIITTP 103
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
53-170 |
9.24e-03 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 37.11 E-value: 9.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308154507 53 AQTGTGKTAAFLISIITQLlqtpppkERYMGepRALIIAPTRELVVQIAKDAAALTKyTGLNVMTFVGGMDFDKQLKQLE 132
Cdd:cd18035 23 LPTGLGKTIIAILVAADRL-------TKKGG--KVLILAPSRPLVEQHAENLKRVLN-IPDKITSLTGEVKPEERAERWD 92
|
90 100 110
....*....|....*....|....*....|....*...
gi 308154507 133 ArfCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADR 170
Cdd:cd18035 93 A--SKIIVATPQVIENDLLAGRITLDDVSLLIFDEAHH 128
|
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