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Conserved domains on  [gi|15599211|ref|NP_252705|]
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hypothetical protein PA4016 [Pseudomonas aeruginosa PAO1]

Protein Classification

C13 family peptidase( domain architecture ID 11468651)

C13 family peptidase similar to human legumain that has a strict specificity for hydrolysis of asparaginyl bonds; contains a COG4642 domain with a MORN repeat

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_C13 pfam01650
Peptidase C13 family; Members of this family are asparaginyl peptidases. The blood fluke ...
 341-547 9.16e-57

Peptidase C13 family; Members of this family are asparaginyl peptidases. The blood fluke parasite Schistosoma mansoni has at least five Clan CA cysteine peptidases in its digestive tract including cathepsins B (2 isoforms), C, F and L. All have been recombinantly expressed as active enzymes, albeit in various stages of activation. In addition, a Clan CD peptidase, termed asparaginyl endopeptidase or 'legumain' has been identified. This has formerly been characterized as a 'haemoglobinase', but this term is probably incorrect. Two cDNAs have been described for Schistosoma mansoni legumain; one encodes an active enzyme whereas the active site cysteine residue encoded by the second cDNA is substituted by an asparagine residue. Both forms have been recombinantly expressed.


:

Pssm-ID: 396290  Cd Length: 257  Bit Score: 191.35  E-value: 9.16e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211   341 LYALSLGGDGRQGVFLREAD--YAGDLLgQRFAARG-VIRLVNHRD--HFGDRPLAT-------RESLSRAV------RT 402
Cdd:pfam01650   1 LWAVLVAGSNGYYNYRHQADvcHAYQLL-KKFGIKDeNIIVMMYDDiaNNPENPFPGkifnkpnGTDVYKGVpkdytgND 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211   403 LAER--------------------SGPEDLVFIYLTSHGSSDhqlALDMPglNLGDLPAAELAELLAPLRQRDK----VL 458
Cdd:pfam01650  80 VTPRnflavllgdksalgsgkvlkSGPNDNVFIYFTDHGAPG---VLGFP--ELDYLYAKDLAEALKKMHARGKykklVF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211   459 VVSACYSGGFIPPL-KDERTLILTAARADRVSFG--CSDDADFTYFGRALLANALNRTDD-------LSKAFELAKEEVR 528
Cdd:pfam01650 155 YVEACESGSMFEGLpKDINVYATTAANADESSYGcyCPDPEDGTYLGDLFSVNWMEDSDDhdlsketLEQQFELVKNRTT 234

                         250
                  ....*....|....*....
gi 15599211   529 QREKEEGFEASEPQAWLPE 547
Cdd:pfam01650 235 GSHVMQYGDKSLPQLPLSL 253
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
31-298 1.68e-39

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 145.48  E-value: 1.68e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211  31 DARLPDGARYRGELVDGRLEGQGRLDYDNGAWYAGRFEHGLLHGHGTWQGADGSRYSGGFAAGLFDGQGRLAMADGSVYQ 110
Cdd:COG4642  14 DATALGGGGEGGLAAAGGEGGGGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGDGGG 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211 111 GGFRQGLFDGEGsleqqgtryrGGFRKGLYSGQGTLDGSDGSRYQGSFRQGRLEGEGSFSDSQGNQYAGTFRDGQLNGKG 190
Cdd:COG4642  94 GEGGFGGGGGGG----------GGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQG 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211 191 RWSGPDGDRYVGQFKDNQFHGQGRYESASGDVWIGRFSEGALNGPGELLGADGSRYRGGFQFWRFHGQGLLEQLDGTRYE 270
Cdd:COG4642 164 TLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYE 243

                       250       260
                ....*....|....*....|....*...
gi 15599211 271 GGFAAGAYAGQGTLDRADGSREQGLWAD 298
Cdd:COG4642 244 GEFKNGKRHGQGTMTYADGSVYEGEWKN 271
 
Name Accession Description Interval E-value
Peptidase_C13 pfam01650
Peptidase C13 family; Members of this family are asparaginyl peptidases. The blood fluke ...
 341-547 9.16e-57

Peptidase C13 family; Members of this family are asparaginyl peptidases. The blood fluke parasite Schistosoma mansoni has at least five Clan CA cysteine peptidases in its digestive tract including cathepsins B (2 isoforms), C, F and L. All have been recombinantly expressed as active enzymes, albeit in various stages of activation. In addition, a Clan CD peptidase, termed asparaginyl endopeptidase or 'legumain' has been identified. This has formerly been characterized as a 'haemoglobinase', but this term is probably incorrect. Two cDNAs have been described for Schistosoma mansoni legumain; one encodes an active enzyme whereas the active site cysteine residue encoded by the second cDNA is substituted by an asparagine residue. Both forms have been recombinantly expressed.


Pssm-ID: 396290  Cd Length: 257  Bit Score: 191.35  E-value: 9.16e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211   341 LYALSLGGDGRQGVFLREAD--YAGDLLgQRFAARG-VIRLVNHRD--HFGDRPLAT-------RESLSRAV------RT 402
Cdd:pfam01650   1 LWAVLVAGSNGYYNYRHQADvcHAYQLL-KKFGIKDeNIIVMMYDDiaNNPENPFPGkifnkpnGTDVYKGVpkdytgND 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211   403 LAER--------------------SGPEDLVFIYLTSHGSSDhqlALDMPglNLGDLPAAELAELLAPLRQRDK----VL 458
Cdd:pfam01650  80 VTPRnflavllgdksalgsgkvlkSGPNDNVFIYFTDHGAPG---VLGFP--ELDYLYAKDLAEALKKMHARGKykklVF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211   459 VVSACYSGGFIPPL-KDERTLILTAARADRVSFG--CSDDADFTYFGRALLANALNRTDD-------LSKAFELAKEEVR 528
Cdd:pfam01650 155 YVEACESGSMFEGLpKDINVYATTAANADESSYGcyCPDPEDGTYLGDLFSVNWMEDSDDhdlsketLEQQFELVKNRTT 234

                         250
                  ....*....|....*....
gi 15599211   529 QREKEEGFEASEPQAWLPE 547
Cdd:pfam01650 235 GSHVMQYGDKSLPQLPLSL 253
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
31-298 1.68e-39

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 145.48  E-value: 1.68e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211  31 DARLPDGARYRGELVDGRLEGQGRLDYDNGAWYAGRFEHGLLHGHGTWQGADGSRYSGGFAAGLFDGQGRLAMADGSVYQ 110
Cdd:COG4642  14 DATALGGGGEGGLAAAGGEGGGGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGDGGG 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211 111 GGFRQGLFDGEGsleqqgtryrGGFRKGLYSGQGTLDGSDGSRYQGSFRQGRLEGEGSFSDSQGNQYAGTFRDGQLNGKG 190
Cdd:COG4642  94 GEGGFGGGGGGG----------GGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQG 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211 191 RWSGPDGDRYVGQFKDNQFHGQGRYESASGDVWIGRFSEGALNGPGELLGADGSRYRGGFQFWRFHGQGLLEQLDGTRYE 270
Cdd:COG4642 164 TLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYE 243

                       250       260
                ....*....|....*....|....*...
gi 15599211 271 GGFAAGAYAGQGTLDRADGSREQGLWAD 298
Cdd:COG4642 244 GEFKNGKRHGQGTMTYADGSVYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 53-264 7.89e-26

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 112.62  E-value: 7.89e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211   53 GRLDYDNGAWYAGRFEHGLLHGHGTWQGADGSRYSGGFAAGLFDGQGRLAMADGSVYQGGFRQGLFDGEGS-LEQQGTRY 131
Cdd:PLN03185   1 GELVLSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTyTGTDGTTY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211  132 RGGFRKGLYSGQGTLDGSDGSRYQGSFRQGRLEGEGSFSDSQGNQYAGTFRDGQLNGKGRWSGPDGDRYVGQFKDNQFHG 211
Cdd:PLN03185  81 KGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHG 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15599211  212 QGRYESASGDVWIGRFSEGALNGPGELLGAdGSRYRGGFQFWR--FHGQGLLEQL 264
Cdd:PLN03185 161 FGVYTWSDGGCYVGTWTRGLKDGKGVFYPA-GSRVPAVQEFYLnaLRKRGVLPDL 214
COG4249 COG4249
Uncharacterized conserved protein, contains caspase domain [General function prediction only];
391-530 3.21e-09

Uncharacterized conserved protein, contains caspase domain [General function prediction only];


Pssm-ID: 443391  Cd Length: 238  Bit Score: 57.64  E-value: 3.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211 391 ATRESLSRAVRTLAERSGPEDLVFIYLTSHGSSDHQ----LALDMPGLNLGD--LPAAELAELLAPLRQRDKVLVVSACY 464
Cdd:COG4249  54 ATRAEIRRALRDFFAKAQPGDVALFYFAGHGIQDDGenylLPVDASPDDLEStaISLSELLDALAESPAKKVLVILDACR 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211 465 SGGF---------------IPPLKDER-TLILTAARADRVSFgcsDDAD-----FTYfgrALLANALNRTD-----DLSK 518
Cdd:COG4249 134 SGPFarggrrsagpsssrgLAELAAGRgTLVLTASAPGQVAL---EGPEgghgvFTY---ALLEGLRGPADgdggiTLEE 207

                       170
                ....*....|..
gi 15599211 519 AFELAKEEVRQR 530
Cdd:COG4249 208 LFKYVRRRVREL 219
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 200-222 3.17e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 35.08  E-value: 3.17e-03
                          10        20
                  ....*....|....*....|...
gi 15599211   200 YVGQFKDNQFHGQGRYESASGDV 222
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
198-218 5.38e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 34.62  E-value: 5.38e-03
                           10        20
                   ....*....|....*....|.
gi 15599211    198 DRYVGQFKDNQFHGQGRYESA 218
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYA 21
 
Name Accession Description Interval E-value
Peptidase_C13 pfam01650
Peptidase C13 family; Members of this family are asparaginyl peptidases. The blood fluke ...
 341-547 9.16e-57

Peptidase C13 family; Members of this family are asparaginyl peptidases. The blood fluke parasite Schistosoma mansoni has at least five Clan CA cysteine peptidases in its digestive tract including cathepsins B (2 isoforms), C, F and L. All have been recombinantly expressed as active enzymes, albeit in various stages of activation. In addition, a Clan CD peptidase, termed asparaginyl endopeptidase or 'legumain' has been identified. This has formerly been characterized as a 'haemoglobinase', but this term is probably incorrect. Two cDNAs have been described for Schistosoma mansoni legumain; one encodes an active enzyme whereas the active site cysteine residue encoded by the second cDNA is substituted by an asparagine residue. Both forms have been recombinantly expressed.


Pssm-ID: 396290  Cd Length: 257  Bit Score: 191.35  E-value: 9.16e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211   341 LYALSLGGDGRQGVFLREAD--YAGDLLgQRFAARG-VIRLVNHRD--HFGDRPLAT-------RESLSRAV------RT 402
Cdd:pfam01650   1 LWAVLVAGSNGYYNYRHQADvcHAYQLL-KKFGIKDeNIIVMMYDDiaNNPENPFPGkifnkpnGTDVYKGVpkdytgND 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211   403 LAER--------------------SGPEDLVFIYLTSHGSSDhqlALDMPglNLGDLPAAELAELLAPLRQRDK----VL 458
Cdd:pfam01650  80 VTPRnflavllgdksalgsgkvlkSGPNDNVFIYFTDHGAPG---VLGFP--ELDYLYAKDLAEALKKMHARGKykklVF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211   459 VVSACYSGGFIPPL-KDERTLILTAARADRVSFG--CSDDADFTYFGRALLANALNRTDD-------LSKAFELAKEEVR 528
Cdd:pfam01650 155 YVEACESGSMFEGLpKDINVYATTAANADESSYGcyCPDPEDGTYLGDLFSVNWMEDSDDhdlsketLEQQFELVKNRTT 234

                         250
                  ....*....|....*....
gi 15599211   529 QREKEEGFEASEPQAWLPE 547
Cdd:pfam01650 235 GSHVMQYGDKSLPQLPLSL 253
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
31-298 1.68e-39

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 145.48  E-value: 1.68e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211  31 DARLPDGARYRGELVDGRLEGQGRLDYDNGAWYAGRFEHGLLHGHGTWQGADGSRYSGGFAAGLFDGQGRLAMADGSVYQ 110
Cdd:COG4642  14 DATALGGGGEGGLAAAGGEGGGGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGDGGG 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211 111 GGFRQGLFDGEGsleqqgtryrGGFRKGLYSGQGTLDGSDGSRYQGSFRQGRLEGEGSFSDSQGNQYAGTFRDGQLNGKG 190
Cdd:COG4642  94 GEGGFGGGGGGG----------GGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQG 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211 191 RWSGPDGDRYVGQFKDNQFHGQGRYESASGDVWIGRFSEGALNGPGELLGADGSRYRGGFQFWRFHGQGLLEQLDGTRYE 270
Cdd:COG4642 164 TLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYE 243

                       250       260
                ....*....|....*....|....*...
gi 15599211 271 GGFAAGAYAGQGTLDRADGSREQGLWAD 298
Cdd:COG4642 244 GEFKNGKRHGQGTMTYADGSVYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 53-264 7.89e-26

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 112.62  E-value: 7.89e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211   53 GRLDYDNGAWYAGRFEHGLLHGHGTWQGADGSRYSGGFAAGLFDGQGRLAMADGSVYQGGFRQGLFDGEGS-LEQQGTRY 131
Cdd:PLN03185   1 GELVLSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTyTGTDGTTY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211  132 RGGFRKGLYSGQGTLDGSDGSRYQGSFRQGRLEGEGSFSDSQGNQYAGTFRDGQLNGKGRWSGPDGDRYVGQFKDNQFHG 211
Cdd:PLN03185  81 KGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHG 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15599211  212 QGRYESASGDVWIGRFSEGALNGPGELLGAdGSRYRGGFQFWR--FHGQGLLEQL 264
Cdd:PLN03185 161 FGVYTWSDGGCYVGTWTRGLKDGKGVFYPA-GSRVPAVQEFYLnaLRKRGVLPDL 214
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 36-213 2.60e-23

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 104.53  E-value: 2.60e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211   36 DGARYRGELVDGRLEGQGRLDYDNGAWYAGRFEHGLLHGHGTWQGADGSRYSGGFAAGLFDGQGRLAMADGSVYQGGFRQ 115
Cdd:PLN03185  30 DGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQ 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211  116 GLFDGEGSLE-QQGTRYRGGFRKGLYSGQGTLDGSDGSRYQGSFRQGRLEGEGSFSDSQGNQYAGTFRDGQLNGKGRWSg 194
Cdd:PLN03185 110 GLQEGPGKYTwANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVFY- 188

                        170       180
                 ....*....|....*....|.
gi 15599211  195 PDGDRY--VGQFKDNQFHGQG 213
Cdd:PLN03185 189 PAGSRVpaVQEFYLNALRKRG 209
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 128-331 7.43e-20

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 93.74  E-value: 7.43e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211  128 GTRYRGGFRKGLYSGQGTLDGSDGSRYQGSFRQGRLEGEGSFSDSQGNQYAGTFRDGQLNGKGRWSGPDGDRYVGQFKDN 207
Cdd:PLN03185   8 GDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLN 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211  208 QFHGQGRYESASGDVWIGRFSEGALNGPGELLGADGSRYRGGFQFWRFHGQGLLEQLDGTRYEGGFAAGAYAGQGTLDRA 287
Cdd:PLN03185  88 LKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWS 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 15599211  288 DGSREQGLWA----DGKRIRDAAGKALPDTLEVGLLA-QGRLLDEELRK 331
Cdd:PLN03185 168 DGGCYVGTWTrglkDGKGVFYPAGSRVPAVQEFYLNAlRKRGVLPDLRR 216
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 33-130 9.73e-11

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 64.85  E-value: 9.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211   33 RLPDGARYRGELVDGRLEGQGRLDYDNGAWYAGRFEHGLLHGHGTWQGADGSRYSGGFAAGLFDGQGRLAMADGSVYQGG 112
Cdd:PLN03185  96 RYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGT 175

                         90
                 ....*....|....*...
gi 15599211  113 FRQGLFDGEGSLEQQGTR 130
Cdd:PLN03185 176 WTRGLKDGKGVFYPAGSR 193
COG4249 COG4249
Uncharacterized conserved protein, contains caspase domain [General function prediction only];
391-530 3.21e-09

Uncharacterized conserved protein, contains caspase domain [General function prediction only];


Pssm-ID: 443391  Cd Length: 238  Bit Score: 57.64  E-value: 3.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211 391 ATRESLSRAVRTLAERSGPEDLVFIYLTSHGSSDHQ----LALDMPGLNLGD--LPAAELAELLAPLRQRDKVLVVSACY 464
Cdd:COG4249  54 ATRAEIRRALRDFFAKAQPGDVALFYFAGHGIQDDGenylLPVDASPDDLEStaISLSELLDALAESPAKKVLVILDACR 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211 465 SGGF---------------IPPLKDER-TLILTAARADRVSFgcsDDAD-----FTYfgrALLANALNRTD-----DLSK 518
Cdd:COG4249 134 SGPFarggrrsagpsssrgLAELAAGRgTLVLTASAPGQVAL---EGPEgghgvFTY---ALLEGLRGPADgdggiTLEE 207

                       170
                ....*....|..
gi 15599211 519 AFELAKEEVRQR 530
Cdd:COG4249 208 LFKYVRRRVREL 219
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
120-301 1.37e-07

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 53.04  E-value: 1.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211 120 GEGSLEQQGTRYRGGFRKGLYSGQGTLDGSDGSRYQGSFRQGRLEGEGSFSDSQGNQYAGTFRDGQLNGKGRWSGPDGDR 199
Cdd:COG4642   1 GGSVAEDGAGGGGDATALGGGGEGGLAAAGGEGGGGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211 200 YVGQFKDNQFHGQGRYESASGDVWIGRFSEGALNGPGELLGADGSRYRGGFQFWRFHGQGLLEQLDGTRYEGGFAAGAYA 279
Cdd:COG4642  81 GGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPH 160

                       170       180
                ....*....|....*....|..
gi 15599211 280 GQGTLDRADGSREQGLWADGKR 301
Cdd:COG4642 161 GQGTLTYADGDRYEGEFKNGKR 182
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 23-99 5.34e-07

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 52.53  E-value: 5.34e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599211   23 EGEPLLPADARLPDGARYRGELVDGRLEGQGRLDYDNGAWYAGRFEHGLLHGHGTWQGADGSRYSGGFAAGLFDGQG 99
Cdd:PLN03185 109 QGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKG 185
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
109-222 5.41e-05

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 43.90  E-value: 5.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599211 109 YQGGFRQGLFDGEGSLEQQGTRYRGGFRKGLYSGQGTLDG------SDGS-RYQGSFRQGRLEGEGSFSDSQGN-QYAGT 180
Cdd:COG2849  29 KNGYKSGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKGKLGewktyyPNGQlKSEGTYKNGKLEGEWKEYYENGKlKSEGN 108

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 15599211 181 FRDGQLNGKGRWSGPDGD-RYVGQFKDNQFHGQGRYESASGDV 222
Cdd:COG2849 109 YKNGKLHGEWKEYYENGKlKEEGNYKNGKKDGVWKYYDENGKL 151
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 200-222 3.17e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 35.08  E-value: 3.17e-03
                          10        20
                  ....*....|....*....|...
gi 15599211   200 YVGQFKDNQFHGQGRYESASGDV 222
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
198-218 5.38e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 34.62  E-value: 5.38e-03
                           10        20
                   ....*....|....*....|.
gi 15599211    198 DRYVGQFKDNQFHGQGRYESA 218
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYA 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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